LOCUS       NC_016109              11896 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 284587
            Orig. end                         :: 296483
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11896
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11896
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11896
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6896](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6896)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(499..514)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     gene            575..1183
                     /locus_tag="KSE_RS01220"
                     /old_locus_tag="KSE_02540"
     CDS             575..1183
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133423.1"
                     /locus_tag="KSE_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02540"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_014133423.1"
                     /transl_table=11
                     /translation="MSTSPPPVPSAPPAPVLRPGDVPERLDAEGLVLRRFRAEEAGVRY
                     AAITASFAHLHRWMGWAARLPSEREHAQRFARALAWPDAGGSYSFGVFAADDRALLGMA
                     GLHDNLGGGAVEIGYWCHADHLGRGVATRAARALTGLLTGLPTVRRVEIHCDEANLRSA
                     AVARRLGYRLDRIEPDGVRAPAESGRGMVWVADGPTGPA"
     gene            1398..1649
                     /locus_tag="KSE_RS01225"
                     /old_locus_tag="KSE_02550"
     CDS             1398..1649
                     /EC_number="3.6.1.7"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019356860.1"
                     /locus_tag="KSE_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02550"
                     /product="acylphosphatase"
                     /protein_id="WP_033259838.1"
                     /transl_table=11
                     /translation="MVSGTVQGVFFRDSCRRAAAEAGVAGWVRNLPDGRVEAVVEGDPD
                     AVEQVVGWLRHGPSRAVVEGVEVIEEQPEGLLVFAVTT"
     gene            complement(1693..2133)
                     /locus_tag="KSE_RS01230"
                     /old_locus_tag="KSE_02560"
     CDS             complement(1693..2133)
                     /EC_number="3.5.4.5"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241417.1"
                     /locus_tag="KSE_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02560"
                     /product="cytidine deaminase"
                     /protein_id="WP_014133425.1"
                     /transl_table=11
                     /translation="MPIDRVLVDAAIDLTRRCFPGQDRGGAAALRLDDGTVLTSAAPRA
                     VNGAVQLCHETGALCEAFKLGRRVTASVCVTAADGDRGFWVLAPCGVCQERLFEHGPDV
                     EVGVPRPEDPRRWRTLRLRDVQPHWFARVFPEDGIWPYEGEE"
     misc_feature    2166..2177
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.98"
                     /tool="antismash"
     gene            2211..2852
                     /locus_tag="KSE_RS01235"
                     /old_locus_tag="KSE_02570"
     CDS             2211..2852
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133426.1"
                     /locus_tag="KSE_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02570"
                     /product="DinB family protein"
                     /protein_id="WP_014133426.1"
                     /transl_table=11
                     /translation="MTDHHTEAAARDGSATAKRDLKLYLQDARDALVWKLAGLSEYDAR
                     RPLTPTGTNLLGLVKHLTGAEAVYFGAAFGRPFEGGPGLWVAGAAEPNADLWARPEEGR
                     EALLADYRRVWAHADATIDALPLSALGEVPWPPHDRLTLGRVLLHVVAETHRHAGHADL
                     VRELVDGATGLRPDGSVLPEGDAAWWAGHRRRVEEAARAAARAAGERLPD"
     gene            complement(2909..4078)
                     /locus_tag="KSE_RS01240"
                     /old_locus_tag="KSE_02580"
     CDS             complement(2909..4078)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="KSE_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02580"
                     /product="MFS transporter"
                     /protein_id="WP_014133427.1"
                     /transl_table=11
                     /translation="MRGFRLLVLGQAASEFGNAFQAVALPMLVYSLGGGTGQLSAVVSA
                     FGIGRLAAAPLGGICADRWGARRVMLAADLGRLAATAALAVAALRHLDDLLLIGTLTCL
                     VGLGAGLFLPASWAVVPDLLPADDLQAGNALSSTVNHTAGLLGPPLAGAVLLWLDPGTG
                     LVVDAATFAVSALTLLLIGRTGERTREDPGADRATGFLALLRGSRMLRGLLAVTVVTNL
                     TVGGMTRIGLPALATGDFAAGAVGFGALLAAFTGGCLLGGPIAAALDGVRHRGRTAGLA
                     ALLMGLAVALVPFAGLPGALVALLVAGVACTVNNVLLITGVQHRTPPALLARVMAALTF
                     CALCAFPLSALAVGAVVTAFGTPGVFVVTGLTMLAATGITFTVREVREM"
     gene            complement(4301..5017)
                     /locus_tag="KSE_RS01245"
                     /old_locus_tag="KSE_02590"
     CDS             complement(4301..5017)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="KSE_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02590"
                     /product="DUF5825 family protein"
                     /protein_id="WP_014133428.1"
                     /transl_table=11
                     /translation="MPPSTERPLLEPLSPIDVELWLDYDPEVQRLPGIALGPRTLDLPA
                     PGAAPGAAPAAADAAAEAVTELHRSGVRCLRLADPVPLCHDAPATAVRALMLVREATAR
                     GLAVRWSAHCADGCVDDGRFHHLHPPIRVTGAAPGHHPAERWRATYFPGKCLYRRGPGF
                     VEVRDRRHGTLELLTIDEPDHLDGIDVLAGGTPADRLPAAVRRDFTDAGLITEQAGLAW
                     WLPMRVRRWPFPAMSV"
     gene            complement(5001..6896)
                     /locus_tag="KSE_RS01250"
                     /old_locus_tag="KSE_02600"
     CDS             complement(5001..6896)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133429.1"
                     /locus_tag="KSE_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02600"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_014133429.1"
                     /sec_met_domain="TIGR03975 (E-value: 1e-188, bitscore:
                     627.3, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.1e-12, bitscore: 46.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILLVQMPWGALDTPSLALGILRAVAERAGHRVEVRYANLEYAD
                     WAAEQHGLDHADYTYFSDRSYFQGAGDWAFAGALYGEQDAGDPREHAPYLEHLAAHGAD
                     EQEVRLVLATRATAPAFVERLAASILADPPDLVGFTSTFQQNTAALATARLLKRADPRI
                     TTVLGGANCDGPQGAALHRNFPFLDHVVRGEGEAALPALLDLLAAGADDFSAVPGLCWR
                     GPDGRSRANPTAARPLPPAAIPAPRYDGYYERFDASVAARWVEPRLVLEGSRGCWWGEK
                     HHCTFCGLNGSAMAYRSKRPEDFLEEILALTERHRLLDIQVVDNILDMGYFETVLRPLA
                     ALPVDLRLHFEIKANLRREQFQLLGDAGAVQVQPGIESLSSRILKLMDKGVTGCQNVRA
                     LRDAQSAGVSVAWNHLYGFPGEHPDDYREILRRLPALHHLDPPVGTGRIAIERFSPYYD
                     DPRLGFPITRPAPHYRATYRLPESELADLAYLFSTEPRGIDDTLAAELTAAVDTWRAHF
                     PDSRLDRLDTGDRIVLANSRPGYAWRTLELTDPAELALFRLLDQPRSPATLAARVPGGA
                     EAVTPLLRHWDDLGLLFHDGERWLQVAVESDNQVLMRVEHRHTTHREEDRRAAVH"
     gene            complement(7002..7154)
                     /locus_tag="KSE_RS42585"
     CDS             complement(7002..7154)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS42585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157850091.1"
                     /transl_table=11
                     /translation="MKRRSVLNDPLNTPEAGRGRGVIVPDSRLAVPPAAPAAGSADTRA
                     AAAAR"
     misc_feature    complement(7182..7192)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     misc_feature    complement(7235..7251)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.91"
                     /tool="antismash"
     gene            complement(7406..8797)
                     /locus_tag="KSE_RS01255"
                     /old_locus_tag="KSE_02620"
     CDS             complement(7406..8797)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145180.1"
                     /locus_tag="KSE_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02620"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_014133430.1"
                     /sec_met_domain="DAO (E-value: 3.6e-52, bitscore: 176.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPVHALRDAKPTPFWLEDPGRPDANSALTGDVRCDLLVVGGGYS
                     GLWTALVAKERDPGRDVVLIEAEQTGWAASGRNGGFCAASLTHGLGNGLERWPDEMAAL
                     EQLGARNLRSIEDAVTRHGIDCDWERTGELDVATEPHQVEELAELHELAKQYGDYELLD
                     TDAIRAQVDSPTYLGALWDKDGVAMLHPAKLAWGLKRACERLGVRVFEHTKALDLAESG
                     SGMAVRTPYGRVFARQVALGTNVFPSLVKRIRPYTVPVYDYAMMTEPLSAEQLASIGWG
                     NRQGVGDSANQFHYYRLSADNRILWGGYDAIYHYGAKVRAEYDQRPQTYQTLARHFFQT
                     FPQLEGLRFTHAWGGAIDTCTRFSAFFDTAYRGKVALAAGYTGLGVGATRFGAEVMLDL
                     LAGERTERTALEMVRRKPLPFPPEPVRWAGIGITKWSLDRADRNAGRRNLWLKTMDKLG
                     LGFDS"
     gene            complement(8884..9258)
                     /locus_tag="KSE_RS01260"
                     /old_locus_tag="KSE_02630"
     CDS             complement(8884..9258)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133431.1"
                     /locus_tag="KSE_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02630"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_014133431.1"
                     /transl_table=11
                     /translation="MIDSFALHVPDAELEPEPLDPGQIVSGTPEVTGKVVWESADGRQV
                     RGIWQITPGVVTDTEADEMFVVLSGRATVAFEGGPVLEIGPGDLAVLREGDRTTWTVHE
                     TLRKVYTINLGPDAAADEDR"
     gene            complement(9255..10751)
                     /locus_tag="KSE_RS01265"
                     /old_locus_tag="KSE_02640"
     CDS             complement(9255..10751)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024910.5"
                     /locus_tag="KSE_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_02640"
                     /product="APC family permease"
                     /protein_id="WP_157850090.1"
                     /transl_table=11
                     /translation="MSLVPLVALIFFSVSGGAYGIEPLFSTSGPGMGILLILVAPLIYS
                     VPHALVCAELGTAIPVEGGYYHWVKRGLGRFWAFQQGLLQWVCSFVDMALYPVMFTSYL
                     SSLISAVAPGKHVLFELAGIQVDLNWVICVGVIVVFTLLNLMGAGWVGDSSVAFAIICL
                     TPMLILTVIGFYQLVTEGTNPISSMTAEQGQSTWNAFGSGLFIVMWNYSGWDSVSTVAG
                     EMENPKKHLPKALLWSVLLIIAGYLLPSLASLAVGPDGENGWKSWQDGALPDIAGELAG
                     PWLQYVVTIGGLFASVAMFSALLASYSRLPSSLSHDGYLPKWVSKESKRYKMPVASIVG
                     SSVVYALFCFSSFQSLVIYDVFLTNIGILLEVAALIALRIREPELERPYKIPGGWWSIG
                     LITASLTGVSVWAAIQQYSEEGTKAVVYCLIVVGASLLLYPLLAARKAARASAAADRAA
                     ANGRDAEAGERSAYELSGQRPDSAHSDRAADGTAADSVEA"
     misc_feature    10796..10810
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(10805..10819)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.7"
                     /tool="antismash"
     misc_feature    complement(10882..10895)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.89"
                     /tool="antismash"
     misc_feature    11541..11557
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.66"
                     /tool="antismash"
ORIGIN
        1 ggtgagcacc acgagttgga cggcggccgc ggaggcgatc ggcccggtga cgctgatcgc
       61 gccgccgagc aggccgaccg cgccgagcag cgggaccgcc caccagccgc cggcggcgcc
      121 gatcagcagg ccgagggcgc cggccagcgc gggcagcgcc tgctgcaggg tgccggtgcg
      181 ccgtccggcg gggcggtcgt tgacgcccgc gaacatcgcg ccgagcccgg ccagcacgcc
      241 ctcggcgggc cgtccggcgg cgaccgcgag gccgagcggc accgccatcc cggcggcgcc
      301 gcggacggtc gccgcccagg gcaccggtcc gcgctgccag cgcagcgggt gggtcagcca
      361 ggcgggccgc gcctgccgcc ggtccgcctg ccggtccgta cgcctgctgt tcgtgggcct
      421 gttcgtggga actcctcacc tcgtggccgt ccgccccccg accgtagccg cggctcttgt
      481 cgtcgccgct gcgcccgcgt tacgcccggg tgacggccgc gatcggccga aatccgatgg
      541 acgcccgggc cggccgtcgg agatcatccg ccccatgagc acctcccctc cccccgtccc
      601 ctccgctccc cccgctcccg tcctccggcc gggcgacgtc ccggagcgcc tggacgccga
      661 ggggctggtg ctgcgccggt tccgggccga ggaggcgggg gtgcggtacg cggcgatcac
      721 ggcctcgttc gcgcacctgc accggtggat ggggtgggcg gcgcggctgc cgtccgagcg
      781 ggagcacgcg cagcggttcg cccgggcgct ggcttggccg gacgccgggg gcagctactc
      841 cttcggcgtc ttcgcggccg acgaccgggc gctgctcggc atggcggggc tgcacgacaa
      901 cctgggcggc ggcgcggtgg agatcggcta ctggtgccac gccgaccacc tcggtcgggg
      961 cgtggcgacc cgggcggccc gggcgctgac cgggctgctg accggcctgc cgaccgtgcg
     1021 gcgggtcgag atccactgcg acgaggccaa tctgcgcagc gcggcggtgg cccgccggct
     1081 cggctaccgg ctggaccgga tcgagccgga cggcgtccgg gccccggcgg agtccggccg
     1141 cggcatggtc tgggtggcgg acgggcccac cggaccggcc tgacgggggg ctttccccgg
     1201 ggccccagcg ggaaaaccgc gtgcgcggtc gccggggcgc cggttggcct cgcgtcctgt
     1261 cctgttcgcc ggtgcgggga ggtggcggcc cggaccggcg ggtcctcgtg ccgtgccgcc
     1321 gtgccgccgc ccggttgcgg tatacctacc ggcaggcggc gacgagaggc gggcaacggg
     1381 tgatccggcg gcgggtgttg gtctcaggca cggtgcaggg cgtcttcttc cgcgactcct
     1441 gccgccgggc ggcggccgag gcgggcgtcg cgggctgggt gcgcaacctg ccggacggcc
     1501 gggtcgaggc ggtcgtcgag ggcgacccgg acgcggtgga gcaggtggtc ggctggcttc
     1561 ggcacggccc gtcccgcgcg gtggtcgagg gcgtcgaggt gatcgaggag cagccggagg
     1621 ggctgctggt cttcgccgtc accacctgaa cccggccgac caccccctca cttcactccc
     1681 cctcgactcc actcactcct cgccttcgta cggccagatg ccgtcctcgg ggaacacccg
     1741 ggcgaaccag tgcggttgga cgtcccgcag ccgcagggtg cgccagcggc gcgggtcctc
     1801 cggccggggg acgccgacct cgacgtccgg gccgtgctcg aacagccgct cctggcagac
     1861 gccgcagggg gcgagcaccc agaagccgcg gtcgccgtcg gcggcggtga cgcagaccga
     1921 ggcggtgacc cggcggccga gcttgaacgc ctcgcagagc gcgccggtct cgtggcacag
     1981 ctgcacggcg ccgttgacgg cgcggggcgc ggcgctggtg aggacggtgc cgtcgtccag
     2041 gcgcagcgcg gccgcgccgc cccggtcctg gccggggaag cagcgccggg tgaggtcgat
     2101 cgcggcgtcc accaggacgc ggtcgatggg catggcgggc acggtaccgg gcgggctcgc
     2161 ggggcgaaaa cggtttgtcg gcggcccggg gcggcgccca gaatccggcc atgacggatc
     2221 atcacacgga ggcggcggcg cgggacggat ccgccaccgc caagcgggac ttgaagctct
     2281 acctgcagga cgcccgggac gcgctggtgt ggaagctggc gggcctgtcg gagtacgacg
     2341 cccgccggcc gctgaccccg accggaacga acctgctggg cctggtcaag cacctgaccg
     2401 gcgcggaggc ggtgtacttc ggcgccgcct tcggccggcc gttcgagggt ggtccggggc
     2461 tgtgggtggc gggcgcggcc gagccgaacg ccgacctgtg ggcgcggccg gaggagggcc
     2521 gggaggcact gctcgccgac taccgccggg tctgggcgca cgcggacgcc accatcgacg
     2581 cgctgccgct gtcggcgctc ggcgaggtgc cgtggccgcc gcacgaccgg ctgacgctgg
     2641 gccgggtgct gctgcacgtg gtcgcggaga cccaccggca cgccggccac gccgacctgg
     2701 tccgcgaact ggtggacggc gcgaccggcc tgcgcccgga cggctcggtc ctcccggagg
     2761 gcgacgccgc ctggtgggcg gggcaccgcc gccgggtcga ggaggccgcc cgcgcggcgg
     2821 cccgcgccgc gggcgagcgg ctgccggact gaccgccgac cggtgtcccc ggcgccggca
     2881 cccccgtccg gcgtccccgt ccgggtggtc acatctcgcg gacctcccgg acggtgaagg
     2941 tgatgccggt ggcggccagc atggtgaggc cggtgacgac gaagacgccg ggggtgccga
     3001 aggccgtgac gaccgcgccg acggccagcg ccgacagcgg gaaggcgcac agcgcgcaga
     3061 aggtgagcgc ggccatcacc cgggccagca gcgcgggcgg ggtgcggtgc tggacgccgg
     3121 tgatcagcag cacgttgttg acggtgcagg cgacgccggc gaccagcagc gcgaccaggg
     3181 ccccggggag tccggcgaac gggacgagcg ccaccgccag gcccatcagc agggcggcca
     3241 gtccggccgt ccggccgcgg tggcggactc cgtcgagggc ggcggcgatc gggccgccga
     3301 gcaggcagcc gccggtgaac gcggcgagca gcgcgccgaa tccgaccgcg ccggccgcga
     3361 agtcgccggt ggccagggcg ggcaggccga tccgggtcat gccgccgacg gtgaggttgg
     3421 tgacgacggt gacggccagc aggccgcgca gcatccggga gccgcgcagc agggcgagga
     3481 atccggtcgc ccggtccgcg ccggggtcct cgcgcgtccg ttccccggtc cggccgatca
     3541 gcagcagggt gagcgcggag accgcgaagg tggcggcgtc gaccacgagt ccggtgccgg
     3601 ggtcgagcca gagcaggacg gctccggcga gcggcggtcc gagcagtccg gcggtgtggt
     3661 tgacggtgct gctgagcgcg ttgccggcct ggaggtcgtc ggcgggcagc aggtcgggga
     3721 cgaccgccca ggaggcgggc aggaagagtc cggcgccgag gccgaccagg caggtgagcg
     3781 tgccgatcag cagcaggtcg tccaggtgcc gcagggcggc gacggcgagc gcggcggtgg
     3841 cggccagtcg gccgaggtcg gcggcgagca tcacccgccg ggcgccccag cggtcggcgc
     3901 agatcccgcc gagcggtgcg gcggcgagcc ggccgatccc gaacgcggag accacggcgc
     3961 tcagttgccc ggtgccgccg ccgagggagt agaccagcat cggcagcgcg acggcctgga
     4021 aggcgttgcc gaactcggag gcggcctggc cgagcaccag cagccggaag ccgcgcaccc
     4081 gcagcggccc cgcggcccac ccgcgccgcc cgatccgtcc tcgccgcccg atccgtccgc
     4141 ccgttccgcg ccagccgcgc caccggctcc gtccgctccg tcctcccccc tgccgcgtcg
     4201 atcgccgtcg gacgtcgagt cggtcggtca tccggtcccc ttccccgttg gagagcagct
     4261 gcggcaagcg gtggacgcgc gcgtcggcgc ccgcggcggg tcagacgctc atcgccggga
     4321 acggccagcg gcgcacccgc atgggcagcc accaggcgag tccggcctgt tcggtgatga
     4381 gtccggcgtc ggtgaagtcc cggcggacgg cggcgggcag ccggtcggcg ggggtcccgc
     4441 cggccaggac gtcgatgccg tcgaggtggt cgggttcgtc gatggtgagc agttccagcg
     4501 tgccgtgccg ccggtcgcgg acctcgacga agccggggcc gcgccggtag aggcacttgc
     4561 cggggaagta cgtggcgcgc caccgttcgg cggggtggtg gccgggggcg gcgccggtga
     4621 cccggatcgg cgggtgcagg tggtggaagc ggccgtcgtc gacgcagccg tccgcgcagt
     4681 gggcgctcca ccggacggcg aggccgcggg cggtggcctc gcggaccagc atcagggcgc
     4741 ggacggcggt ggcgggggcg tcgtggcaga gcgggacggg gtcggccagc cgcaggcagc
     4801 ggacgccgga gcggtgcagt tcggtgacgg cctcggcggc ggcgtcggcg gccgcgggag
     4861 cggccccggg ggcggccccg ggggcgggga ggtcgagggt gcgcgggccg agcgcgatgc
     4921 cgggcaggcg ttggacctcg gggtcgtagt cgagccagag ttcgacgtcg atgggtgaga
     4981 gcggttcgag tagcgggcgt tcagtggacg gcggcacggc ggtcctcctc gcggtgggtg
     5041 gtgtgccggt gctcgacccg catcagcacc tggttgtcgg actcgacggc cacctgcagc
     5101 cagcgttcgc cgtcgtggaa gagcaggccg aggtcgtccc agtgccgcag cagcggggtg
     5161 acggcctcgg cgccgccggg gacgcgggcg gcgagggtgg cgggcgagcg gggctggtcg
     5221 agcagccgga acagggcgag ttcggcgggg tcggtcagtt cgagggtgcg ccaggcgtag
     5281 ccggggcggg agttggcgag cacgatccgg tcgccggtgt cgagccggtc gagccggctg
     5341 tcggggaagt gcgcgcgcca ggtgtcgacg gcggcggtga gttcggcggc cagggtgtcg
     5401 tcgatgccgc gcggttcggt gctgaacagg taggccaggt cggcgagttc gctctcgggc
     5461 agccggtagg tggcgcggta gtggggggcg gggcgggtga tcgggaagcc gagccgcggg
     5521 tcgtcgtagt aggggctgaa ccgttcgatg gcgatccggc cggtgccgac cggcgggtcg
     5581 aggtggtgca gggcgggcag tcggcggagg atctcgcggt agtcgtcggg gtgttcgccg
     5641 gggaagccgt agaggtggtt ccaggcgacg gagaccccgg cgctctgggc gtcgcgcagg
     5701 gcgcggacgt tctggcagcc ggtgacgccc ttgtccatga gcttcaggat ccggctgctg
     5761 aggctctcga tgccgggctg cacctgcacc gccccggcgt cgccgagcag ttggaactgt
     5821 tcgcggcgca ggttggcctt gatctcgaag tgcagccgca ggtcgaccgg gagggcggcg
     5881 agcgggcgca gcacggtctc gaagtagccc atgtcgagga tgttgtcgac cacctggatg
     5941 tcgagcaggc ggtgccgttc ggtgagcgcg aggatctcct ccaggaagtc ctcggggcgc
     6001 ttggagcggt acgccatggc ggagccgttc agcccgcaga aggtgcagtg gtgcttctcg
     6061 ccccaccagc agccgcggga gccctccagg acgagcctgg gttcgaccca gcgggccgcg
     6121 acggacgcgt cgaaccgctc gtagtagccg tcgtagcggg gggcggggat cgcggcgggc
     6181 ggcagcgggc gggcggccgt cgggttggcc cgggagcggc cgtcggggcc gcgccagcac
     6241 aggccgggca cggcggagaa gtcgtcggcg ccggccgcga gcaggtcgag cagggcgggg
     6301 agggcggcct cgccctcgcc gcgcaccacg tggtcgagga acgggaagtt gcggtgcagc
     6361 gcggcgccct gcgggccgtc gcagttggcg ccgccgagga cggtggtgat ccgcgggtcg
     6421 gcccgcttga gcagccgggc ggtggcgagc gcggcggtgt tctgctggaa ggtgctggtg
     6481 aagccgacca ggtcgggcgg gtcggcgagg atcgaggcgg ccagccgttc gacgaaggcg
     6541 ggggcggtgg cgcgggtggc caggacgagt cggacctcct gctcgtcggc gccgtgcgcg
     6601 gccaggtgct ccaggtacgg cgcgtgctcc cgcgggtcgc ccgcgtcctg ttcgccgtac
     6661 agcgcgccgg cgaaggccca gtcgccggcg ccctggaagt aggagcggtc ggagaagtag
     6721 gtgtagtcgg cgtggtcgag gccgtgctgc tcggccgccc agtcggcgta ctccaggttg
     6781 gcgtaccgca cctcgacccg gtggccggcc cgttcggcga cggcgcgcag gatgccgagg
     6841 gccagggagg gcgtgtcgag cgccccccac ggcatctgca ccaggaggat cttcatggct
     6901 ctcgtcctgt ggggtcgggt gccgccccgg gacggggtcc cggggcggcg cggtccgtcg
     6961 cgcgcggagc cggggaggcg gttcccccgc gcggggtggc gttaccgcgc ggccgcggcc
     7021 gcgcgggtgt ccgcggagcc ggcggccggg gcggccggcg gcacggccag ccgggagtcg
     7081 ggcacgatga cgccccggcc tcggccggcc tcgggggtgt tgagcgggtc gttcagcacg
     7141 ctgcgtcgct tcacgggatt gcacgtcctc tcatatgacg tgtgacatgg cacaagccgg
     7201 atgcagctac tgtaggcccg gagcgagaac gtccgtacgc gatacgggta gttggccgaa
     7261 acccgccact acgaccacca ctccggcccc acccgggccc atccgtcccg ccggccccgg
     7321 acgcgcgacg gccgcccgcg cggggggtgc gcgggcggcc gtcggggcgg tccggggtca
     7381 acgggccggt gtcagcggcc tggtgtcagc tgtcgaagcc gaggccgagc ttgtccatgg
     7441 tcttgagcca gaggttgcga cggccggcgt tgcggtcggc gcggtccagg gaccacttgg
     7501 tgatgccgat gccggcccag cggaccggct cgggcgggaa cggcagcggc ttgcggcgga
     7561 ccatctccag cgcggtgcgc tcggtgcgct cgccggccag caggtcgagc atcacctcgg
     7621 cgccgaaccg ggtggcgccg acgccgaggc cggtgtagcc ggcggcgagg gcgaccttgc
     7681 cgcggtaggc ggtgtcgaag aaggcggaga accgggtgca ggtgtcgatc gcgccgcccc
     7741 aggcgtgggt gaagcgcagg ccctccagct gcgggaaggt ctggaagaag tgccgggcga
     7801 gcgtctggta ggtctgcggc cgctggtcgt actcggcgcg gaccttggcc ccgtagtggt
     7861 agatcgcgtc gtagccgccc cacaggatcc ggttgtcggc ggacagccgg tagtagtgga
     7921 actggttggc gctgtcgccg acgccctgcc ggttgcccca gccgatcgag gcgagctgtt
     7981 cggcgctgag cggctcggtc atcatcgcgt agtcgtagac cggcacggtg tacgggcgga
     8041 tccgcttgac cagcgacggg aagacgttgg tgccgagcgc gacctggcgg gcgaagaccc
     8101 ggccgtaggg ggtgcgcacg gccatgccgg agccggactc ggcgaggtcg agggccttgg
     8161 tgtgctcgaa gacccggacg ccgagccgtt cgcaggcccg cttgaggccc caggcgagct
     8221 tggcggggtg gagcatcgcc acgccgtcct tgtcccagag cgcgccgagg taggtgggcg
     8281 agtcgacctg ggcccggatc gcgtcggtgt cgagcagctc gtagtcgccg tactgcttgg
     8341 cgagttcgtg cagttcggcg agttcctcga cctggtgcgg ctcggtggcg acgtcgagtt
     8401 cgccggtgcg ctcccagtcg cagtcgatgc cgtgccgggt gacggcgtcc tcgatggacc
     8461 gcaggttgcg ggcgccgagc tgttcgagcg cggccatctc gtccggccag cgttccaggc
     8521 cgttgccgag gccgtgggtg aggctggcgg cgcagaagcc gccgttgcgg ccggaggcgg
     8581 cccagccggt ctgctcggcc tcgatcagga ccacgtcgcg cccggggtcc cgctccttgg
     8641 cgaccagggc cgtccacagg ccgctgtagc cgccgccgac gaccagcagg tcgcagcgga
     8701 cgtcgccggt gagggcggag ttcgcgtccg ggcggcccgg gtcctccagc cagaacgggg
     8761 tgggtttggc gtcccgcagt gcgtgtacgg ggtccatgct ctcggttcct tgcctagaga
     8821 gggtgcggcc cggcctcccc gggcggggcg gccgggccgg tgggtgcttc gcaggagggg
     8881 tggttatcgg tcctcgtccg cggccgcgtc cgggccgagg ttgatggtgt agaccttgcg
     8941 gagcgtctcg tggacggtcc aggtggtgcg gtcgccctcg cgcaggacgg cgaggtcgcc
     9001 ggggccgatc tccaggaccg gcccgccctc gaaggcgacg gtggcccggc cgctgaggac
     9061 gacgaacatc tcgtcggcct cggtgtcggt gaccaccccg ggggtgatct gccagatccc
     9121 gcggacctgg cggccgtcgg cggactccca gaccaccttg ccggtgacct cgggcgtgcc
     9181 ggagacgatc tgcccggggt cgagcggctc gggctccagt tcggcgtccg ggacgtgcag
     9241 ggcgaagctg tcgatcatgc ttcgacgcta tcggcagcgg tgccgtcggc ggccctgtca
     9301 ctgtgtgccg agtccggccg ctgccctgac agctcgtacg ccgaccgctc cccggcctcg
     9361 gcgtcccggc cgttcgcggc ggcccggtcg gccgccgcgg aggcccgggc ggccttgcgg
     9421 gcggccagca gcgggtagag caggagggag gcgccgacca cgatcaggca gtagacgacg
     9481 gccttggtgc cctcctcgct gtactgctgg atggcggccc agacgctgac gccggtcagg
     9541 ctggcggtga tcaggccgat gctccaccag ccgccgggga tcttgtacgg gcgctccagc
     9601 tcgggctcgc ggatccgcag cgcgatcagc gcggcgacct ccagcaggat gccgatgttg
     9661 gtgaggaaga cgtcgtagat caccaggctc tggaagctgg agaagcagaa cagcgcgtag
     9721 accaccgagg agccgacgat cgaggcgacc ggcatcttgt agcgcttgct ctccttggag
     9781 acccacttgg gcaggtagcc gtcgtgcgag agcgaggagg gcagccggga gtacgaggcg
     9841 agcagcgcgg agaacatcgc gaccgaggcg aacaggccgc cgatggtgac gacgtactgg
     9901 agccagggcc cggcgagttc gccggcgatg tcggggagcg cgccgtcctg ccagctcttc
     9961 cagccgttct cgccgtccgg gccgacggcc agcgaggcca gcgagggcag caggtagccg
    10021 gcgatgatca gcaggacgga ccagagcagc gccttgggca ggtgcttctt cgggttctcc
    10081 atctcgccgg ccacggtgga gaccgagtcc cagccggagt agttccacat cacgatgaac
    10141 aggccggagc cgaaggcgtt ccaggtggac tggccctgtt cggcggtcat cgaggagatc
    10201 gggttggtgc cctcggtgac cagctggtag aagccgatca cggtgaggat cagcatcggg
    10261 gtcaggcaga tgatcgcgaa ggcgaccgag gagtcgccga cccagcccgc gcccatcagg
    10321 ttcagcagcg tgaagaccac gatgacgccg acgcagatca cccagttcag gtcgacctgg
    10381 atgcccgcga gttcgaacag cacgtgcttg ccgggggcga ccgcgctgat caggctggag
    10441 aggtacgagg tgaacatcac cgggtacagc gccatgtcga cgaagctgca cacccactgc
    10501 agcaggccct gctggaaggc ccagaaccga ccgaggccgc gcttgaccca gtggtagtag
    10561 ccgccctcga cggggatggc ggtgccgagc tcggcgcaga ccagggcgtg cggcacgctg
    10621 tagatcagcg gggcgaccag gatcagcagg atgcccatgc cggggccgga ggtcgagaac
    10681 agcggctcga tcccgtaggc gccgccggag acgctgaaga agatcagggc caccagggga
    10741 accaggctca cgcgcttggg cgtcgcccac cgggtctccg gcggggccgc ggggatggcg
    10801 gtcattttca ccttggcaat cgggtctcgg ctcggatgtg tctcggttga gaggcacgag
    10861 tcttgtcgtc ccgttgacat aggacaatca ttcaatctgt cagacgtctt gttgcccctc
    10921 tgacagagtg ccgggcccgc ccccgccccg ctccgttcga catcgtgcca ggtcagagcc
    10981 catacgagcc gccgcccccg agcccggtcg agcgaaatgc ccggttcgcg ccccccgcgc
    11041 cggacgatga tcaccggccc gcccgcgcct cccacacccc ggcgggcggc cccggtagcg
    11101 ttcaccgggc catgcccacc atcaccgacg cctccgactc cccccggccc ctgctcaacc
    11161 gggtcgtccg gctctcgccc ttcctgctga tcgccctgtc cgccgccgcg gacgccgaga
    11221 ccccggccgg gcagcgctac gaccgcttcg tggtcgccgc gcccgccctc gccgcggcga
    11281 cctggggctc gttcgggacg ctggtgatcg gcgcgatcgc ggtggccacc gaggtggtgc
    11341 tggcggtgat ccgggacggg cgggtcggcg cggcgggcgc ctcggtgatc gccgccaccg
    11401 tgaccgtcac gctggccgcc tcgtacacct ccggcatgcg ggtgcgccgc gagcgcgacc
    11461 tggcgctggt ccgctcggtg gcgcgcaccg cgcagcaggt ggtgctgcgg ccgctgccgg
    11521 accggatcgg cgacgtcggg ctggcgctgt actacagcgc ggcggccgag caggcccaga
    11581 tcggcggcga cctgtacgag gcggtgcgca ccccgttcgg ggtgcggatc atcctgggcg
    11641 acgtccaggg caagggcctg cccgccgtcg aactggcggc cgcgctgctc ggctcgttcc
    11701 gggaggccgc ctacgacgcg ccggacctgc ccgcgctggc cacccggctg gaggtcggcc
    11761 tgcagcggta cgccgagcgg gcctcctctc ccgacgccgc cgaacgcttc gccaccgccg
    11821 tgctgctgga gatcccgaac ggctcggcgg tggcctacct gctgaactgc ggccacccgc
    11881 cgccggtcct gctcgg
//
