LOCUS       NC_016109              10894 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 121172
            Orig. end                         :: 132066
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10894
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10894
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10894
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5894](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5894
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            59..1258
                     /locus_tag="KSE_RS00500"
                     /old_locus_tag="KSE_01030t"
     CDS             59..1258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133275.1"
                     /locus_tag="KSE_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_01030t"
                     /product="transposase"
                     /protein_id="WP_014133275.1"
                     /transl_table=11
                     /translation="MAEDMSRAAAALAQSRLSAFTEELFGHLPRADQRRWAQAYLRGLL
                     VTPGKKSVRRLASAVSDSPTASQSLQQFINASPWDWRPARRELTRVVEQHAPTEAWSVA
                     AAVLPKRGDHSCGVHRRFVPSAGRTVNCQVGVGVFLSSGGQDVPVDWRLLLPDQWDDDA
                     VLRERTRIPPAVRHRPLWAHTLDLVDTLASRTSQAPAPVVADMSEYPDAGRLVEGLSRR
                     GRDFVIAVPGTLRVVPGGLRAAAPDLHAPLSARQLLYPSGTRHPHTATLPAPDRRLRSV
                     RILSGLARLHLPRQDAPAARHTYRLFTQWRPGGGQQPARMWITNLVDRRIDRLIALSQL
                     HRGTTTAMRSLEQEYGMLDFEGRSYPGWHHHMTLVSAAYTYNRLVHPAQQPGEPVHQSA
                     "
     gene            complement(2084..3796)
                     /locus_tag="KSE_RS46160"
     CDS             complement(2084..3796)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.5"
                     /locus_tag="KSE_RS46160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_331457801.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5e-05, bitscore:
                     21.3, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRCWSGAGAVRSGCCPLSAVRVVAGPGVLSAGGVGVRALPGSVV
                     GGGGGRRPVSGVGWRRCCGWCPPAGLGGWLRGVCPVVAGGPGGSAGCLCVLAPCVRRGF
                     PRRGWRGGSVAGPGPGPGPGLGPAPAPGPGCGPAPAPGPGCGPAPAPGPGCGPGCGFGW
                     WGGADCRVGSGGGWSRPVEWRVFVLFGGRSARVWWGSAGGGGVAWSAGGAVSPGPGPGP
                     GPGPGPGPGPGLGPGGWRSLRGRRVGGRRIVLSGATGFVGSVVLEGLVRGWAGAAGGGG
                     VELRVVSRRPPVGGGGVVEWVWGDLAEPASLRGVCEGADVLVHLASYIGADEGMCEAVN
                     VAGSAALVGEAVRAGVGRIVGLSTAAVYGVGPHSGIGVDEVEPVPVSVVSRTRLAGEGP
                     VLAAGGIVLRPGLVLGEGDRWVVPALAELVERVPARWEGGRGLLSAVAVGDLGRLIVRL
                     ACASRAVGGGLYHASHPVPVRVGDLLAVLAAHGVLPSVAQREELSWEACLERLRARPGR
                     VSARQLELLTRDHWYRSERVWRAAGCPAGPGVLARTAQAARWYRSHLDPRPTA"
     gene            complement(4120..4761)
                     /locus_tag="KSE_RS00510"
                     /old_locus_tag="KSE_01050t"
     CDS             complement(4120..4761)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133277.1"
                     /locus_tag="KSE_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_01050t"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_014133277.1"
                     /transl_table=11
                     /translation="MAEPKQERAVRTREVILYAAAEVFDECGYSGASISKIMQRSGATQ
                     GGMYFHFKSKEGLAHAVMASQQEFIRLPPGRDGLQRLIDITFHIAGELQRNVLFRASVR
                     LAVEQGELGLEDDTAYQEWVQRFHAQLVAARECGELLEGVDEWEFATVLVGAYTGTQIF
                     SNVATGRADLPERIASLWRYLLPAVATPQAAVLLRVEPSVGPPSGRVSAG"
     misc_feature    4806..4819
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.5"
                     /tool="antismash"
     gene            5001..5894
                     /locus_tag="KSE_RS00515"
                     /old_locus_tag="KSE_01060t"
     CDS             5001..5894
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133278.1"
                     /locus_tag="KSE_RS00515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_01060t"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_158413044.1"
                     /sec_met_domain="AfsA (E-value: 2.2e-21, bitscore: 74.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKEYVHRASLSEVFLTGWHQTAPDTFTVTAQWPRSHSFYTTDHH
                     THDPLLLSETIRQTFPLLTHAAYHLPFGHQLSWSHFQIRLDPRAMRIEPTPAEIELHVT
                     ATNIRYHRGLPASMTMHYTARRDGQPLATATTHFHCHTPTVYQRLRAGRATTAHPFHTA
                     PPPPHPLTPTTAGRTHHHDIVLSPTPHPHHWQLRVDTHHPVLFDHPVDHVPGMLLLEAT
                     RQATNTLTTPRKPHIITHLDITFNRYVELDTPCYIHAHTTHHNPTNHHNPTHHITATQA
                     DTTAFTAHTHTTPLPT"
     gene            complement(6267..6509)
                     /locus_tag="KSE_RS37975"
                     /old_locus_tag="KSE_01070"
     CDS             complement(6267..6509)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS37975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_01070"
                     /product="hypothetical protein"
                     /protein_id="WP_014133279.1"
                     /transl_table=11
                     /translation="MSDLCLGLKDGSGAAVCPTDHAVAWSEVTATVPQARGGAEIAVKL
                     IPGATYSVCFPDFPTGSPTPKFNAPGTGRQVTFVH"
     gene            <6684..8042
                     /locus_tag="KSE_RS46290"
                     /old_locus_tag="KSE_01080"
                     /pseudo=""
     CDS             <6684..8042
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024935.5"
                     /locus_tag="KSE_RS46290"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_01080"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="DALLEPTDAAPCTDGPMKTPAGLALAPQHQRGHHAPHGTPNRGRP
                     NTDPPRTEPAGLPLPRAADGRPVLAVDVSPWPRPDAGTCPDHSSRHTYRHGDAKHQAIP
                     DRPYPFVVALETGRTSWTTAPDTVRPNPDPDAAATTAAPLRDMAAPSITAGQRTTGDPE
                     APAVMDTDYDTPRIAHPPGNHPPGDQPTQAPGRLRPNRVTHRPAPTRAKWHAAHPAGGR
                     PPKHGGESAFGDPATRGDKQEATTTETRHHATTTVRTRDRHHPRPTRRAARPDHDSELP
                     LLQSTVIQPAIEKLPSGEVNRPTRPYRSPTDTDPADIDHCRHPPPPTVVPAQVRPGTHL
                     PPARTDTGPNPTPPARLRGNRPPDPDHDRHPHPAPPRPAHPLITDLHHPQENPAEPNKP
                     TPTHTRRGSRSVRAAAARPCRTTPPVREPRTGGARPLPAALEAHPIFHTSTNE"
     gene            8133..8519
                     /locus_tag="KSE_RS00525"
                     /old_locus_tag="KSE_01090"
     CDS             8133..8519
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133281.1"
                     /locus_tag="KSE_RS00525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_01090"
                     /product="beta/gamma crystallin domain-containing protein"
                     /protein_id="WP_014133281.1"
                     /transl_table=11
                     /translation="MSAGFAPKEIPVFPRTKRTTFSAALAFAAATALTVAVPSGNAYAI
                     DHIECKGGEDYLKIWSHLDGRQSVDCYANAGRTDFGGWWIDRISTGNNDLIYYDVNGDS
                     VKIERWHDITFPNHPPRVKSIQIL"
     gene            complement(8915..9214)
                     /locus_tag="KSE_RS00530"
                     /old_locus_tag="KSE_01100"
     CDS             complement(8915..9214)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS00530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_01100"
                     /product="hypothetical protein"
                     /protein_id="WP_148283039.1"
                     /transl_table=11
                     /translation="MGTVLLPVWFLGFLVLNALATFVKFGDAGCDDGSSGCMGAGPGAR
                     AAVVVLLGVVVLAVVVTWLLPCVRRLRVARWVLVAVSVLLGVVVLAVGVSRPSH"
     gene            9554..10015
                     /locus_tag="KSE_RS00535"
                     /old_locus_tag="KSE_01110"
     CDS             9554..10015
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133283.1"
                     /locus_tag="KSE_RS00535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_01110"
                     /product="hypothetical protein"
                     /protein_id="WP_014133283.1"
                     /transl_table=11
                     /translation="MSDDVLSIIPSDPRWQPNREAVDRVVALVEDLVPGRADDMEVDVR
                     WHDTVTVVDCGENLERIGCPLCQAAIDTEWWSDLLEAHCDDGFTTLAVEVPCCGGSTTL
                     DVLDYDWPCGFARFEIAIWNPERSWFREDELTALADRLGHPVRQIRAHI"
     gene            complement(10253..10417)
                     /locus_tag="KSE_RS42565"
                     /old_locus_tag="KSE_01120"
     CDS             complement(10253..10417)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS42565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_01120"
                     /product="hypothetical protein"
                     /protein_id="WP_157850113.1"
                     /transl_table=11
                     /translation="MAGERSEDLPGPSRPVGRAAAERIESALLSALRHSPFLEPGTGLP
                     APVPAAAGS"
     misc_feature    complement(10826..10840)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 aacaaagcga acgttctcta ttatcttggg aggagcccag ccggggagga aacagaggat
       61 ggccgaagac atgtcccgcg cggcggccgc gctcgcccag tcgcgcctca gcgccttcac
      121 cgaggagctg ttcggccatc tgccgcgcgc cgaccagcgc cgctgggccc aggcgtacct
      181 gcgggggctg ctggtcacgc cgggcaagaa gtcggtgcgc cggctggcgt cggcggtctc
      241 cgactccccg acggcctccc agtcgctgca gcagttcatc aacgcgagcc cgtgggactg
      301 gcgccccgcg cgccgggagc tgacgcgggt ggtcgagcag cacgccccga ccgaggcctg
      361 gtccgtcgcc gcggccgtgc tgcccaagcg cggggaccac tcgtgcggcg tccaccgccg
      421 tttcgtgccg tcggccgggc gtaccgtcaa ctgccaggtg ggggtggggg tgttcctgtc
      481 ctcgggcggg caggacgtgc ccgtggactg gcggctgctg ctgcccgacc agtgggacga
      541 cgacgcggtg ctgcgcgagc gcacacgcat cccgcccgcc gtccgccacc gccccctgtg
      601 ggcccacacc ctcgacctgg tggacaccct cgcctcccgc acctcgcagg cgcccgcgcc
      661 ggtcgtggcg gacatgagcg agtacccgga cgccggccgg ctggtcgagg gcctcagccg
      721 gcgcggacgc gacttcgtca tcgccgtgcc gggcaccctg cgggtggtgc ccggcggact
      781 gcgcgccgcc gcccccgacc tccacgcccc cctcagcgcc cgccagctgc tgtacccctc
      841 cggcacccgc cacccgcaca ccgcgacgct ccccgccccc gaccggcggc tgcgcagtgt
      901 ccgcatcctg tcggggctgg cccgcctgca cctcccgcgc caggacgccc ccgccgcgcg
      961 gcacacctac cggctgttca cccagtggcg ccccggcggc gggcagcagc ccgcccggat
     1021 gtggatcacc aacctcgtgg accggcgcat cgaccggctg atcgccctct cccagctgca
     1081 ccgcggcacg acgacggcga tgcgctccct ggagcaggag tacggaatgc tcgacttcga
     1141 gggccgctcc taccccggct ggcaccacca catgacactg gtctccgccg cctacaccta
     1201 caaccgcctc gtccacccgg cccagcaacc gggcgagccg gtacaccaga gcgcctgaac
     1261 accagaacgc ctgaacgccc ggacgcccgg acgcccggac atcagagcgc cccgcccccg
     1321 gggacacccc gaaagcggcc ccccgcccgc gcgggggctc ccccgacagc cccccgcacg
     1381 ggagccggac accgcgcgcc ccgccacacc caaagacgcc cgcaccgccg gcacgcacca
     1441 gcccgccacc ccgcgcgaac cccggaacac cccacacccg ccacccctcc ccccgagccg
     1501 ccgcgtccgg acggcgggtg cccgggcgtc cgggcggcgg gcggcgggcg tccgggcgtc
     1561 ccgcaccgaa acagcgggcc ccgcacaccc cccgcgaacc aaccccccac ccccgcacgg
     1621 accccggcat cccgcaccca ccgcaccgaa aacacccgca cccaccgcac cggggacggc
     1681 cgacaccctc cgccccgcca ccccttcccc cgagccgccg cgtccggacg gcgggtgccc
     1741 gggcgtccgg gcgtccgggc ggcgggcgtc cgggcgtccc gcaccgaaac agcgggcccc
     1801 gcacaccccc cgcgaaccaa ccccccaccc ccgcacggac cccggcatcc cgcacccacc
     1861 gcaccgaaaa cacccgcacc caccgcaccc accgggccca ccgcaccggg gacggcggac
     1921 atccgcaccg cccccgtcga gacaccttga cggcggggcg gcggtggcgg ccgccggggc
     1981 ggcgtccggc ccgcacgggc acggccacgg ccacggccac ggcaggacgg tgcgaggccg
     2041 gggccgcggg ggcgggggcg ggggcggtca ggcggtcagg cggtcaggcg gtcgggcgcg
     2101 ggtcgaggtg cgagcggtac cagcgtgccg cctgtgccgt ccgggccagc acaccggggc
     2161 cggccgggca gcccgccgcc cgccacaccc gctcgctgcg gtaccagtgg tcgcgggtga
     2221 gcagctccag ctgccgggcg ctcacccgtc ccggccgcgc ccgcagccgc tccaggcagg
     2281 cctcccagga cagctcctcc cgctgcgcga ccgacggcag caccccgtgg gcggcgagca
     2341 ccgccagcag gtcccccacc ctgaccggca cgggatggct cgcgtggtac agaccaccgc
     2401 ccaccgcccg ggacgcgcac gccagacgga cgatcagccg gcccagatca ccgaccgcca
     2461 ccgccgacaa caacccgcgg ccgccctccc accgggccgg cacccgctcg accagctccg
     2521 ccagcgcggg aacgacccac cggtccccct cccccagcac caggcccggc cgcaacacga
     2581 tccctcccgc cgccaggacc ggcccctccc ccgccaaccg cgtacggctc accaccgaaa
     2641 cgggcaccgg ctcgacctcg tccacaccga tcccgctgtg cggccccacc ccgtacaccg
     2701 ccgccgtcga gagacccacg atccgcccca cccccgcccg aacggcctcc cccaccaacg
     2761 ccgcgctccc cgcgacattg accgcctcgc acatcccctc gtccgcaccg atgtaactgg
     2821 cgagatgcac cagcacatcc gccccctcac acaccccgcg caacgacgcc ggctccgcca
     2881 gatcccccca cacccactcc accaccccgc caccccccac cggaggccga cgcgacacca
     2941 cccgcaactc caccccccca ccacccgcgg cacccgccca cccgcgcacc aacccctcca
     3001 ggaccaccga accgacgaac cccgtcgccc cgctcagcac gatcctgcga ccccccaccc
     3061 gccgaccacg caacgaacgc cacccacccg gccccaaccc cggccccggc cccggccccg
     3121 gccccggccc cggccccggc cccggccccg gcgacacggc acccccggca gaccacgcca
     3181 caccaccccc acccgcgctc ccccaccaca ctcgcgccga cctccccccg aacaaaacga
     3241 acaccctcca ttcaaccggc cgcgaccacc caccaccaga gcccacccgg caatccgcac
     3301 caccccacca cccgaaccca cacccggggc cgcacccggg gccgggtgcg ggtgcggggc
     3361 cgcacccggg gccgggtgcg ggtgcggggc cgcacccggg gccgggtgcg ggtgcggggc
     3421 cgagcccggg gccggggccg gggccggggc cggccaccga accaccccgc cacccccgcc
     3481 gcgggaagcc gcgacggacg cacggcgcaa ggacacaaag gcaccccgcg gacccgcccg
     3541 gcccacccgc caccaccgga cagacacccc gcaaccaccc gccgagcccg gccggcgggc
     3601 accacccgca acaccgccgc cacccgacac cggacaccgg acgacggccc ccgccacccc
     3661 cgaccacgga accaggcaac gcccgaacac cgaccccacc ggccgacagc accccgggac
     3721 cagccacgac ccgcacagcg gacagcggac agcacccgga ccgaacagcg ccggccccgg
     3781 accaacagcg caccaccccc cgcagccagg acccggcccc gacgaccaga gccgcgagaa
     3841 ccggacagca ccccccgcag acggagacgg agacgggacc aacggcgacc ccgccggccg
     3901 gccccgccgg cgcaccaccc cgaaccgaaa cggacagcgc ccccggccac cggccacccg
     3961 accccgctca ccccgccgag acccgaccag acggcgcacc accccgagcc gaaacggaca
     4021 gcgcccccga ccaccggcca cccgaccccg ctcaccccgc tcaccccgcc gagacccgac
     4081 cagacggcgg cccgaccgac ggctccaccc ggcccccgct caccccgccg agacccgacc
     4141 agacggcggc ccgaccgacg gctccacccg caacagcacc gccgcctggg gggtggcgac
     4201 cgccggaagc agataccgcc acagcgaagc gatccgctcg ggcaggtccg cccgcccggt
     4261 cgccacgttg gagaagatct gcgtccccgt gtaagccccc accagcaccg tcgcgaactc
     4321 ccactcgtcg acgccctcca gcagctcacc gcactcccgc gccgcgacaa gctgcgcgtg
     4381 gaaccgctgg acccactcct ggtacgccgt gtcgtcctcg agccccagct ccccctgctc
     4441 caccgccaga cgcacactcg cgcggaacag cacattgcgc tgcagctccc ccgcgatatg
     4501 gaacgtgatg tcgatcagcc gctgcagacc gtcccgcccc ggcggcagcc ggatgaactc
     4561 ctgctgactc gccatgaccg cgtgcgccaa cccctccttc gacttgaaat gaaagtacat
     4621 cccgccctgc gtcgcccccg accgctgcat gatcttactg atgctggcac cgctgtaacc
     4681 gcactcgtcg aagacctcgg ccgccgcgta aaggatcacc tcacgcgtcc gcacggcacg
     4741 ctcctgcttc ggttcagcca cagccaggcc ccgcttccac tcggcaaaca aaacgaacgc
     4801 cctctatttt acagacgaac ctcggtctag ggtcagggtg ttgcaccatg tacgccacgg
     4861 gagtgacaca ccccgagcac agcacgtccg accgggcggc ccacaggcca ccggccccac
     4921 ctcgcacgcc aaaaaagggg aacggcatgc tcgtcaccac gcaacctcac accggcccac
     4981 ggcccgcact caccaccaca gtggccaaag agtacgtcca ccgcgcgtca ctgtccgaag
     5041 tcttcctcac cggctggcac caaaccgctc ccgacacctt caccgtcacc gcccaatggc
     5101 cccgcagcca cagcttctac accaccgacc accacaccca cgaccccctc ctgctgtccg
     5161 aaaccatccg ccagaccttc cccctcctca cccacgccgc ctaccacctc cccttcggcc
     5221 accaactcag ctggtcgcac ttccagatac ggctcgaccc ccgcgccatg aggatcgaac
     5281 ccacacccgc cgagatcgaa ctccacgtca ccgccaccaa catcaggtac caccgcggcc
     5341 tgcccgcctc catgaccatg cactacaccg cccgacgcga cggccaaccc ctcgccaccg
     5401 ccaccaccca cttccactgc cacaccccca ccgtctacca acgcctacgc gccggccgcg
     5461 ccaccaccgc ccacccgttc cacaccgccc ccccaccccc ccaccccctc acccccacca
     5521 ccgccggacg cacccaccac cacgacatcg tcctctcccc caccccccac ccccaccact
     5581 ggcaactacg cgtcgacacc caccaccccg tcctcttcga ccaccccgtc gaccacgtcc
     5641 ccggcatgct cctcctcgaa gccacccgcc aagccaccaa caccctcacc accccccgaa
     5701 aaccccacat catcacccac ctcgacatca ccttcaaccg ctacgtcgaa ctcgacaccc
     5761 cctgctacat ccacgcccac accacccacc acaaccccac caaccaccac aaccccaccc
     5821 accacatcac cgccacccag gccgacacca ccgccttcac cgcccacacc cacaccaccc
     5881 ccctccccac ctgacaacca acccccgaaa accaccccac ccacccaccc ccgaaaacca
     5941 cccccaaaca accaaggcgg ccgttcccca cacccccaaa cacccagcaa caaaacacaa
     6001 aagaacggcc gccacacaca cccccccaac ccaccaccaa acaacccaac accccacccc
     6061 acccccgaac caaaccccac gaacaccccc acacccaccg aacccaccaa aaaaccacca
     6121 cacacaaaca gaccagcaaa acccccaccc caccccacca ccgctaccgc cgccaccacc
     6181 accaccacca ccaccaccgg cgaccgaaca ccggcaggac caccgcgcgc cggacaccgg
     6241 cgggcacgtg cgggggtggg cgccggtcaa tggacgaagg tgacctgccg gccggtgccc
     6301 ggggcgttga acttcggggt cggactcccg gtggggaagt ccgggaagca gacggagtac
     6361 gtcgcaccgg ggatcagctt caccgcgatc tccgctccac cgcgggcctg gggcaccgtc
     6421 gcggtgacct cgctccaggc gacggcgtgg tcggtggggc agacggcggc gccgctgccg
     6481 tccttcagcc ccaggcagag gtcgctcaag cgttcccgaa acggcggtgc ggccttcgca
     6541 tgatcctgaa ctcgaccaag agataaagga cttgacgcga aggccgcagc gatgagcgca
     6601 gtgcagcagg atgtgcgggg cgagccgtcc gcggaactgc cacgcttccg ggagtcttcc
     6661 acgactgccc gaccgggcgg cgcgacgcgc tgctcgagcc gacggacgcg gcgccgtgca
     6721 ccgacgggcc gatgaagacc ccggcgggcc tcgcgctggc gccccagcac cagcgcgggc
     6781 accacgcccc gcacggcacg ccgaaccgcg gccgccccaa caccgacccg ccacggaccg
     6841 agccggccgg cctgccactg ccccgcgccg ccgacggccg cccggtgctc gcggtggacg
     6901 tctcgccatg gccgcgcccg gacgccggga cctgcccgga ccactcctcc cgccacacct
     6961 accgccacgg cgacgccaag caccaagcga tccccgaccg gccgtacccg ttcgtcgtcg
     7021 cactggagac cgggcggaca tcgtggacga cggccccgga cacggtacga ccgaaccccg
     7081 accccgacgc cgcggccacc accgccgccc cactccgcga catggcagcc ccgtcgatca
     7141 cagccgggca gcggacaacg ggcgatccgg aggccccggc ggtaatggac accgactacg
     7201 acaccccgcg catcgcccac ccgcccggca accacccgcc cggcgaccag ccaacccagg
     7261 cccccggccg actccgcccg aaccgggtga cgcaccgccc ggcaccgacc cgggccaagt
     7321 ggcacgccgc tcacccggcc ggcggccgac cacccaaaca cggcggcgag tccgccttcg
     7381 gcgaccccgc cacccggggc gacaagcagg aggccaccac caccgagacc cgccaccacg
     7441 ccaccaccac cgtacgaacc cgagaccggc accacccccg cccgacccgc cgcgcggccc
     7501 gaccggacca cgacagcgaa ctcccgctcc tccaaagcac ggtgatccag cccgccatcg
     7561 agaagctacc cagcggcgag gtgaaccggc cgacccggcc ctaccggtcg cccaccgaca
     7621 ccgacccagc cgacatcgac cactgccgac atccaccgcc accgacagtc gttcctgcgc
     7681 aggttcgacc cggaacacac cttccgcccg ctcgaacaga caccggaccg aacccgaccc
     7741 cgcccgcacg actccgcggc aaccgaccac cggacccgga tcatgaccgc cacccacacc
     7801 cagccccgcc ccgccccgcc cacccactca tcaccgacct ccaccacccc caggagaacc
     7861 cagccgaacc gaacaaaccc acccccaccc acacccgccg ggggtcacgc agcgtccgcg
     7921 cggcagcggc gaggccgtgc cgcacgactc cacccgtacg ggagccgaga acgggcggag
     7981 cacggccgct cccggcagcc ctggaagccc atcccatttt tcatacgagc acgaacgagt
     8041 gaagtttcac aacaccggtc cgtatccgga gcggtgcgtc cgacaccgcg tggcacctcg
     8101 ctacgttggg ggctcccccg cccgctgacg gcatgtcagc gggcttcgca ccgaaggaga
     8161 tccccgtgtt cccaaggacc aagcggacca cgttctcggc agccctggcg ttcgccgcgg
     8221 ccaccgccct caccgtcgcc gtacccagcg gcaacgccta cgccatcgac cacatcgagt
     8281 gcaagggcgg cgaggactac ctcaagatct ggtcccacct cgacggccgg cagagcgtcg
     8341 actgctacgc caacgccggc cgcaccgact tcggcggctg gtggatcgac cggatctcca
     8401 ccggcaacaa cgacctcatc tactacgacg tcaacggcga ctcggtgaag atcgagcgct
     8461 ggcacgacat caccttcccc aaccaccccc cacgggtgaa gtccatccag atcctctgac
     8521 ccgccgctca caccccggcc gaccgacggg cgtcgggacg cgaccgcgtc ccgacgcccg
     8581 acaccaccca gacagcgaag accggccagg cccaagaccc cggggagggc cggacgacaa
     8641 cacccgcgag cagcaacaac cagcggtggc agcggtggcg gtcgcgacgc aacacgtatc
     8701 ggaaggcacc ggcaccacgg gcaggccgcc aggaggaggc ccaccgcgct gtcggcaccc
     8761 ggcactccac ccgccgccgg gcgtacggag catggaagcc accacccgat atcccaccgc
     8821 accggcatga gcgcgatcac cagccgcccc gccacacacg cccccgcgcc ggagcgctct
     8881 tcccggcacc gcccacaccg gtaccggtcg ccgctcagtg cgagggccta ctcacaccga
     8941 cggccagcac caccacaccg agcagcacac tcacggccac caggacccag cgggccacac
     9001 gcagacgccg cacgcacggc agcaaccaag tgacgacgac cgccaacacc accacaccca
     9061 acaagacgac caccgcggcc ctggccccgg gacccgcgcc catgcaccca ctcgatccgt
     9121 catcgcaacc ggcgtcaccg aatttcacga acgtcgcgag cgcgttcaag accagaaacc
     9181 cgagaaacca caccggcaac aggaccgtac ccaccagccc cggcacccac cacccaccac
     9241 ccacggtccc ggtccaccgg cacctgccac tgcgtcatcg accgacctcc ccctgccgaa
     9301 ccctaccgcc cgacaccccc gaccacgaca accacccctc aggcggccgc gtgggcgtga
     9361 accgagaacg gatgccggtg ggtttcggca tcgcctggta ccgggccggc tccggggtgt
     9421 tgccgaggtc tggagacacg caccggcccg tgccgggcgc ttcaggtccg ggacggtgtg
     9481 gcgcgagaac gtccgatcgg taacatcgcg tcgcgccttg ccgtggtcgg tggcctgatg
     9541 agatggggaa gccatgagcg atgacgtcct gtcgatcatt ccgagcgatc cgcggtggca
     9601 accgaatcgc gaggcggtcg atcgcgtcgt cgcgctcgtc gaggacctgg ttcccggtcg
     9661 tgccgacgac atggaggtcg acgtgaggtg gcacgacacg gtgaccgtcg tcgactgcgg
     9721 ggagaacctg gagagaatcg gctgcccctt gtgccaggcg gccatcgaca cagagtggtg
     9781 gagcgatctc ctggaggctc actgcgacga cgggttcacc acgctcgcgg tcgaggtccc
     9841 gtgctgcgga ggatccacca ctctggacgt gctggattac gactggccct gcggtttcgc
     9901 ccgtttcgag atcgcgatct ggaaccccga gcgctcctgg ttccgcgagg acgaactgac
     9961 ggccctggcg gatcgactgg gccatccggt gaggcagatc cgagcccaca tctgaacctc
    10021 cgcacctcag aggaccacct actgctgacc ggcgcgggcc cgggtgccgg ccgggcggca
    10081 ggagtcggtg ccggtctcga tccctcggtc gaaacgcgga acggcaactc ggcgccgcgg
    10141 cggtcgagtt ccatcaccgc cgccgctccc ggcccgcgcc cggcgggctc cggcgcaacc
    10201 gcagcgaacg ggtctgcggc gtgcccgccg gctgccgcgg gccgcaggcg tgtcagctgc
    10261 ccgcggcagc cgggacgggc gcgggcaggc cggtgcccgg ctccaggaac ggcgagtgcc
    10321 gcagcgcgct caacagggcc gactcgatcc gctccgccgc cgcccggccg accggccgac
    10381 tcgggccggg caggtcttcg gagcgttcgc cagccatgac gccctccgaa gagcgccggg
    10441 aacgccgctc ccccaccggg gcgtcccccc gtagcgcgag aacccgcccg gacaccccct
    10501 accggtggtt ccgctcctcg ctcggcagtg agtgccagag gtcgagccag ttgtgcagca
    10561 ggaagagcgg tcgggtcagg ttgatgtcgc ccgcgctttg ggagcggatc gcgaggccga
    10621 ggtcggggaa gaccggttcg gcggcgacgc tgtacatcag agggccgcgc agcggccggt
    10681 gaacgagcca gtcctccaac cgggacggta cgcagccggt cagcggaaca ccgtcgagcc
    10741 gtacctgggg accggtgagg gcgtccacgg ccacgcactc caggcggttc acccggaaga
    10801 gcgccctgac tccagcggtg cggaaatcga cgtggctgag cctgcgctcg caggtgccgg
    10861 gagcgtagta gcccgagacg gtcccctctt cgcc
//
