LOCUS       NC_018681              23641 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Nocardia brasiliensis ATCC 700358, complete sequence.
ACCESSION   NC_018681
VERSION     NC_018681.1
KEYWORDS    RefSeq.
SOURCE      Nocardia brasiliensis ATCC 700358
  ORGANISM  Nocardia brasiliensis ATCC 700358
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Complete genome sequence of Nocardia brasiliensis HUJEG-1
  JOURNAL   J Bacteriol 194 (10), 2761-2762 (2012)
   PUBMED   22535940
REFERENCE   2  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-SEP-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
REFERENCE   3  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000250675.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 01:53:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,551
            CDSs (total)                      :: 8,489
            Genes (coding)                    :: 8,417
            CDSs (with protein)               :: 8,417
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 13 of 72
            Pseudo Genes (incomplete)         :: 63 of 72
            Pseudo Genes (internal stop)      :: 3 of 72
            Pseudo Genes (multiple problems)  :: 6 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:09:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7620180
            Orig. end                         :: 7643821
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003876.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23641
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="44"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23641
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23641
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13641](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13641
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    88..103
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    complement(596..605)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.89"
                     /tool="antismash"
     misc_feature    complement(673..687)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            833..1159
                     /locus_tag="O3I_RS33875"
                     /old_locus_tag="O3I_033720"
     CDS             833..1159
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS33875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_033720"
                     /product="hypothetical protein"
                     /protein_id="WP_014987544.1"
                     /transl_table=11
                     /translation="MKAFAVATGIVAVVLAASAPVATAAPQEIAIINGLVYQDQYGDLA
                     RCISVGPMDITVENYTSKRTAYIYNSDDCTGNPVGTVAPGAKGAAYGITVDFKKPAGGG
                     SFEW"
     gene            complement(1352..2410)
                     /locus_tag="O3I_RS33880"
                     /old_locus_tag="O3I_033725"
     CDS             complement(1352..2410)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013347.4"
                     /locus_tag="O3I_RS33880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033725"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_014987545.1"
                     /transl_table=11
                     /translation="MGIRLVARCVRGLESVVAAEVLRLGLGAVVELGHREIHCHTLSSA
                     SQVLRLRTADDAFVLAATAPDIGRRKNSVAVLAGLVADLDVPRLWEARERCGGPPGLGG
                     GIEVSASFLGRRNFNRYDVEDAVGGALSEQLGLHYHSRRGGARPPDSGSGWRVTLDGQH
                     ARLMLRIATHPLHRRPYKQQSVPGSLHPPVASAMVQLADLRPGDRVLDPCCGAGTLLLE
                     ARHLQPAATYRGFDADPAAVRATRANAAATIPARLGDAANVPLPPGSIDRIVCNPPWDS
                     QAPARGLLSHSSLPLWTELRRLLTANGIAVLLIPDARELATAIHAGFTPTHLQQVRISG
                     RPSFLIRVAPAS"
     gene            complement(3536..3985)
                     /locus_tag="O3I_RS46635"
     CDS             complement(3536..3985)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS46635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_237748179.1"
                     /transl_table=11
                     /translation="MDDISENSPGVQRLWLRISGGCAMVGGGGFLLVGVMHGDLPDEDV
                     TAAVRFVADHPHWYVTHLAGILCVLLWAGAFYGLPRTLRTALGCVLGRFAALSMGIGAA
                     IFAVDSPSMGSPSSASPISGRPRPTPRRNGICSSPTRCSQCYMAR"
     gene            complement(4061..5230)
                     /locus_tag="O3I_RS33895"
                     /old_locus_tag="O3I_033735"
     CDS             complement(4061..5230)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019403.4"
                     /locus_tag="O3I_RS33895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033735"
                     /product="DUF418 domain-containing protein"
                     /protein_id="WP_041563042.1"
                     /transl_table=11
                     /translation="MTALATSTDPRTGHAPPRLLGVDAVRGLALLGVFLMHFHMSGWLQ
                     TGAPDAAPAPVAWFQNETSSRAMSLFILLAGVSVALMTGGARPYTGQRMSLARRRLAVR
                     AGMIFLIGLCLESAAPNVLEFYGVLLLLLVPCTGLRPRTLALMSAAAVPAVTLYAVWVM
                     NNHMSWLMTEIPSGPAILLQPQHWAAYLFSLVGYGGGFQTVYGIPLVLAGLAIGRLDLR
                     ATAVRLRMAGGGLALALTASAVAALVPHLLPAGDLLTWRSLFDMPGATAPYATSLVGIT
                     FMIGVALLLLGLLLPLLDRPRAQSLLWPLVAAGSMTLTWYVGHLLFLYSVLEPRTQFSV
                     AGFGGVIVAVLALSALWRKRFRRGPLEWLVHIAMVTAGNPKQGRQRKRP"
     gene            complement(5298..5801)
                     /locus_tag="O3I_RS33900"
                     /old_locus_tag="O3I_033740"
     CDS             complement(5298..5801)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS33900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_033740"
                     /product="hypothetical protein"
                     /protein_id="WP_141691879.1"
                     /transl_table=11
                     /translation="MKLPGRQREWTPIRPVALLLAAAVCGGCGISGSAVFAGGDAPTGI
                     APGVTLYFVAADGTVTPEFRETGKLGTVGEALDLMRRTQPGPGLHTEIPEAEGGPAPLV
                     TEFDTLITVDMPYTRTELSDHAIAQVACTALGVHRQAGRPSATVLIKPTIGPDFGSLTC
                     PVQR"
     gene            complement(5798..7213)
                     /locus_tag="O3I_RS33905"
                     /old_locus_tag="O3I_033745"
     CDS             complement(5798..7213)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="O3I_RS33905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033745"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_014987549.1"
                     /transl_table=11
                     /translation="MRWPRGLRARLLAAFVLVTVIGAAAAAWAGFVSARASLTSDAQNS
                     AAAEVAARITAAAPSLTDPPDQQTLDRLRDLIGGRVWVCYGNLTAATDSDRELVTDELR
                     KAVRDSGGLMLQRISGPRLLIGTPVMVTGVDGRRTRSGIEVYAVRDLSETQARIADSGR
                     AAALTSLLALPLAAGLALLAARGVLRPVRELRDTARRLADGDLTARGNPRGGDELSELT
                     VTVNHMAAQLESTVDRLRASEAESRRFVADVSHELRTPLTALTAVVEVLEAESDRMTGD
                     QRASALLAVDATRRLTTLVADLIEVSRFDAAAERLHPEDVEIVAAVRDSLAARLWDDDR
                     VRLRAMEPVEAIVDRRRLDVIVANLVGNALSHGAPPVQVDIHTAGEDVLITVDDHGTGL
                     PATDPDRVFTRFYKADAGRGGAGGSGLGLAIAREHARLHGGDITAGRAPTGGARFTVRL
                     PRTPGRPAAGSRP"
     gene            complement(7210..7884)
                     /locus_tag="O3I_RS33910"
                     /old_locus_tag="O3I_033750"
     CDS             complement(7210..7884)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080270.1"
                     /locus_tag="O3I_RS33910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033750"
                     /product="response regulator transcription factor"
                     /protein_id="WP_014987550.1"
                     /transl_table=11
                     /translation="MARILLIEDDPLIRDSLAMALRRHGHEVRVAASGEEGLSLAADGV
                     ELVVLDVMLPGMDGFEVCRRLRARGDVAVIMLTAREDDIDVVGGLEAGADDYVVKPVLP
                     RVLDARIKAVLRRGGRDVQSGTVRFGELEIDRDGLTVAKNGVAVALTRTELRLLLELSG
                     APGQVFSRQQLLERVWEHDYLGDSRLVDNGIQRLRAKIEGDPAAPLFVQTVRGFGYRFG
                     PI"
     misc_feature    complement(9108..9121)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    9450..9462
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    9495..9513
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.82"
                     /tool="antismash"
     gene            10001..11041
                     /locus_tag="O3I_RS33915"
                     /old_locus_tag="O3I_033755"
     CDS             10001..11041
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="O3I_RS33915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033755"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_041563043.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3e-61, bitscore:
                     206.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTVRARPGRSATEILAETRKVFEPAYRSAVTALPADIATVGGY
                     HIGWWDAQRTPTQLGGKSIRPALVLASAAANTRGSAELTRERAIIAAVAVEMVHDFSLL
                     HDDIMDNDEIRRHRCAAWATFGVPAAILTGDLFLTAATNLLISQDRDAARILIKALHAL
                     CEGQTEDLAFENRPSVSLPECLHMVEGKTAALLSASCELGAWAAHAGPEKATLMRQFGL
                     QLGFAFQLVDDLLGIWGDPEITGKPVFADLVHRKKSLPVVAALNSHTTAGIELAQRYSG
                     TDLLSQAELEDLARLIELAGGRRWAEDAAAEHISAAQHLLEQAEPNPAAAADLLTLAGL
                     ITRRER"
     gene            11258..>11542
                     /locus_tag="O3I_RS33920"
                     /old_locus_tag="O3I_033760"
                     /pseudo=""
     CDS             11258..>11542
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011273699.1"
                     /locus_tag="O3I_RS33920"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033760"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSIIYLRTPRAPLPMAARRVSRRLMVGSVPVGGGAPISVQSMCTT
                     STADTDAILQQIAELTAAGCEIVRVAVPSRDDARALPRIVARSPIPVIAD"
     misc_feature    11498..11500
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11687..12601
                     /locus_tag="O3I_RS44260"
     CDS             11687..12601
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_UbiA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="O3I_RS44260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_141691878.1"
                     /sec_met_domain="TS_UbiA (E-value: 1.3e-77, bitscore:
                     259.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ubiA (E-value: 2.3e-19, bitscore: 68.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDRSAAPTISLKTRRLLSVSAHEIRTTCTLFSLDNTFITLVPGV
                     TFTVSVSAAAESRPAELFNIAAGSMLYFFLYGYFFTLSNQIAGLEEDRLNKPHRPLVRG
                     LVDVDGMRRRLIGATAAFILTGWLLGVIEWALIWVAISFMHNQLHWSRNWIFKNITMLV
                     GIIAMLAAGASLANYLNDTTWRWIVVISAANFALVSLQDLRDTAGDEAVGRRTFPQYFG
                     INRTRILLAIGFIAYPALLHCTLYAEPRYFSTATVLEVIIAIFSAIISLRIATAETARA
                     DHITYVIYCYQYCLILASPALVI"
     misc_feature    11870..11872
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12371..12373
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12696..12706
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    12741..12759
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.79"
                     /tool="antismash"
     gene            12763..13641
                     /locus_tag="O3I_RS44265"
                     /old_locus_tag="O3I_033765"
     CDS             12763..13641
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_UbiA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="O3I_RS44265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033765"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_167829196.1"
                     /sec_met_domain="TS_UbiA (E-value: 3.7e-50, bitscore:
                     169.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ubiA (E-value: 5.8e-27, bitscore: 93.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHHQLTMEPEIAIRMMMTNTISVVFVTNMFALSAAVYFDVHGGEL
                     LKTLAISFALSVLFLYTWDSSNQVRSRAEDSINKPYRPLPTGLATPRGMLTRYILAAAL
                     LVSFSLPLNIWLWSTGWLIATFFNHLIARPRDYIWTKVPTNCLAFFCMTAAAWRLSGPI
                     DSTGWRWLCLMTIFTCLPQIFEDLRDIHGDAAVGRRTPVAIFGQLPVRLFFFTMVAATP
                     VVMHIYLWQDATSSRTTLMVCDVMVASFSWTTAIRALALRSVRSDAITFQLFTVSVGIS
                     LLSGIFVWANR"
     misc_feature    12790..12801
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    12895..12897
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13072..13074
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13300..13302
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13543..13545
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13894..13909
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 23.47"
                     /tool="antismash"
     gene            14272..15006
                     /locus_tag="O3I_RS44270"
                     /old_locus_tag="O3I_033770"
     CDS             14272..15006
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024214.4"
                     /locus_tag="O3I_RS44270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033770"
                     /product="NTP transferase domain-containing protein"
                     /protein_id="WP_014987554.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.2e-20, bitscore:
                     72.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVVLAAGSGSRMGALTATHPKCMLRMYGTTLLERQLEALARGG
                     ADDIAVVTGWRAGSWEPTGLRALHNSLWEESTVVDSLAAARGWLADEPFVVAYGDVLFS
                     AATVAALLRSFWPTAVAYDPDWEPKWRKRFGGPLIDAETFRHDAAGRLTEIGARPRDVS
                     EIDGRYAGLIKLTPSWWTFYDELGGRGMELTTMLGELIRSKRLTVGTVAITTPWWEFDQ
                     PSDLPLGLPAVRALDDLVKGAP"
     misc_feature    14473..14475
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14848..14850
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15071..16075
                     /locus_tag="O3I_RS33925"
                     /old_locus_tag="O3I_033775"
     CDS             15071..16075
                     /NRPS_PKS="Domain: PKS_ER (14-331). E-value: 3.2e-35.
                     Score: 113.7. Matches aSDomain:
                     nrpspksdomains_O3I_RS33925_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113070.1"
                     /locus_tag="O3I_RS33925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033775"
                     /product="NADPH:quinone reductase"
                     /protein_id="WP_041563045.1"
                     /sec_met_domain="ADH_N (E-value: 2.5e-07, bitscore: 29.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.3e-17, bitscore:
                     62.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVIVYSETGPSSVLRLVERPDPAPGPGEVVVRIVRAGVNPADWG
                     FRAAPGPVDGELAPGQDGAGFVEAAGPGVDHVAVGDRVWLLLAQQGHGYGTASELTVQP
                     AHRVVPLPESASFDLGAALGVPFLTAHRLLTSGSVTRLGPAALAGQTVLVAGGAGAVGN
                     AAIQLARWAGARVIATVSSSTKARLARAAGAHHVLNYRESDPAPEILGIAPGGVDLIAE
                     VAPAQNNALDLAVAKIHGTVSIYADNGGDTLTLPLRETYRKNLRYQFTVLHSLDTALLR
                     AAIDDVSSALTERALRVGEDAGLPLHHYSLEQTAAAHDAVEQGAIGKVLLDLK"
     aSDomain        15113..16063
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS33925_PKS_ER.1"
                     /evalue="3.20E-35"
                     /label="O3I_RS33925_PKS_ER.1"
                     /locus_tag="O3I_RS33925"
                     /protein_end="331"
                     /protein_start="14"
                     /score="113.7"
                     /tool="antismash"
                     /translation="LRLVERPDPAPGPGEVVVRIVRAGVNPADWGFRAAPGPVDGELAP
                     GQDGAGFVEAAGPGVDHVAVGDRVWLLLAQQGHGYGTASELTVQPAHRVVPLPESASFD
                     LGAALGVPFLTAHRLLTSGSVTRLGPAALAGQTVLVAGGAGAVGNAAIQLARWAGARVI
                     ATVSSSTKARLARAAGAHHVLNYRESDPAPEILGIAPGGVDLIAEVAPAQNNALDLAVA
                     KIHGTVSIYADNGGDTLTLPLRETYRKNLRYQFTVLHSLDTALLRAAIDDVSSALTERA
                     LRVGEDAGLPLHHYSLEQTAAAHDAVEQGAIGKVLL"
     CDS_motif       15515..15577
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O3I_RS33925_0001"
                     /evalue="2.00E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="O3I_RS33925"
                     /protein_end="169"
                     /protein_start="148"
                     /score="20.3"
                     /tool="antismash"
                     /translation="GQTVLVAGGAGAVGNAAIQLA"
     CDS_motif       15587..15634
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O3I_RS33925_0002"
                     /evalue="5.90E-04"
                     /label="PKSI-ER_m6"
                     /locus_tag="O3I_RS33925"
                     /protein_end="188"
                     /protein_start="172"
                     /score="12.7"
                     /tool="antismash"
                     /translation="GARVIATVSSSTKARL"
     gene            16184..17629
                     /locus_tag="O3I_RS33930"
                     /old_locus_tag="O3I_033780"
     CDS             16184..17629
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012363.4"
                     /locus_tag="O3I_RS33930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033780"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_014987556.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.8e-06, bitscore:
                     26.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKTRFGAVRGETSDAVSVFKGVPYAAALDGKNRFLPPQPPQPW
                     DGVRPAHAFSAVPPQGSMAGTVGEWRPGDSTDCLTVNVWTPDIGNSRLPVMVWFYGGAF
                     RFGGTSNPQYDGAVLAHDGVVVVTVNYRVGYEGYGWVEDSPANRGTLDQLAALHWIQDN
                     IAEFGGDPDKVTIFGQSAGGTSVAMLVSSPVSAGLFQRAIVQSPSSRFYSAAESRRVSE
                     LILAGIGAPPTVAALTGVPPETIHAAEGAALAAFAADPSAWTATEAFTPYYPVIGDEVL
                     PTTPWAGMRAGAGRGVDLIAGFTRDEFRLYAHPGSVTSPDITAHSEGLATGAIQAYREA
                     HPGLPEPDLDVLIRSDALFRMPSLYCARSHARAGGRTFAYEFTFPSPIEPRALGAYHGI
                     DVPFIFGSAKGAAAELIGSETNLDPLSRQIRTAWTSFARTGDPGWPQYRVGEMLTRIWH
                     NPPTVESDPEAASRLIWQSHYEP"
     gene            18087..19334
                     /locus_tag="O3I_RS33935"
                     /old_locus_tag="O3I_033785"
     CDS             18087..19334
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028221.4"
                     /locus_tag="O3I_RS33935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033785"
                     /product="acyltransferase"
                     /protein_id="WP_014987557.1"
                     /transl_table=11
                     /translation="MSIEATTETLVRALDGSELQFAAVGYCVGYSVCVHGVLELESLTE
                     AFTTLQTANPVLSCRIVASALGGAALARAGDAPYIRVRDNAYSATGSTGIGHRTAGIEV
                     QYEDVDTAWVTLLIHHAIADAGHALRMVEDLWRYYTAAIDGREVAVQRQPYPQSTEFIL
                     RHHGIDDVDPRPEADPVTAARDSSTTPNSTAAPVGLVRLTSEQTRAVIELGHAAGATVN
                     GLVSAALLCAVADAAEVDLPEVRYSFPVDLRSRLEPPVGLTEATNMLSMARFAPPPGSS
                     ADLLELARAVTGKLACDLADGSLTRYYFYPSDQIAAWQAEYSYRPATVSATNWGVIPEL
                     VTPDSLIVRDFRPHPQVTDPVGASVMTPLAPYYVLFIYTFQGQLSITGLAPSAAEAEEL
                     AELLRHQLHRLTSLST"
     misc_feature    18141..18143
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19530..20615
                     /locus_tag="O3I_RS33940"
                     /old_locus_tag="O3I_033790"
     CDS             19530..20615
                     /EC_number="1.1.1.306"
                     /GO_function="GO:0050607 - mycothiol-dependent formaldehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0010127 - mycothiol-dependent
                     detoxification [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (24-257). E-value: 8.1e-14.
                     Score: 43.4. Matches aSDomain:
                     nrpspksdomains_O3I_RS33940_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013471397.1"
                     /locus_tag="O3I_RS33940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033790"
                     /product="S-(hydroxymethyl)mycothiol dehydrogenase"
                     /protein_id="WP_014987558.1"
                     /sec_met_domain="ADH_N (E-value: 8.6e-24, bitscore: 82.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-24, bitscore:
                     85.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVQTVLGVVARSVGAAVEVAEIVIPDPGPGEAVVRVQACGVCHTD
                     ANYRDGIGGGDFPILLGHEASGTVEAVGADVTDIAPGDFVILNWRAVCGACRACRRGKS
                     WNCAAPLTAGQRPTLADGTALTPVLGLGALAEKTLVHARQCTKVDPEVAPAAAALIGCG
                     IATGVGAALWTGAVDRGDTVAVIGCAGVGSAAVAGARIAGAEKIIAVDTDRRRLGWART
                     FGATHTVDARATEPVARIRELTDGHGADVVIDAIGRLDTWKQAFYSRDTAGTVVLLGVP
                     TPDIVLDIPLLDLRVGGGALKSAWYGNCLPSRDFPYLIGLYRQGHLDLDAFVTETITLD
                     QVEDAFRKLRNEEVLRTVVVL"
     aSDomain        19602..20300
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS33940_PKS_ER.1"
                     /evalue="8.10E-14"
                     /label="O3I_RS33940_PKS_ER.1"
                     /locus_tag="O3I_RS33940"
                     /protein_end="257"
                     /protein_start="24"
                     /score="43.4"
                     /tool="antismash"
                     /translation="PDPGPGEAVVRVQACGVCHTDANYRDGIGGGDFPILLGHEASGTV
                     EAVGADVTDIAPGDFVILNWRAVCGACRACRRGKSWNCAAPLTAGQRPTLADGTALTPV
                     LGLGALAEKTLVHARQCTKVDPEVAPAAAALIGCGIATGVGAALWTGAVDRGDTVAVIG
                     CAGVGSAAVAGARIAGAEKIIAVDTDRRRLGWARTFGATHTVDARATEPVARIRELTDG
                     HGADVVIDAIG"
     CDS_motif       19710..19748
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O3I_RS33940_0001"
                     /evalue="2.10E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="O3I_RS33940"
                     /protein_end="73"
                     /protein_start="60"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LGHEASGTVEAVG"
     CDS_motif       20334..20360
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O3I_RS33940_0002"
                     /evalue="9.20E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="O3I_RS33940"
                     /protein_end="277"
                     /protein_start="268"
                     /score="0.1"
                     /tool="antismash"
                     /translation="RDTAGTVVL"
     gene            complement(20628..21848)
                     /locus_tag="O3I_RS33945"
                     /old_locus_tag="O3I_033795"
     CDS             complement(20628..21848)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037653.4"
                     /locus_tag="O3I_RS33945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033795"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_167829197.1"
                     /transl_table=11
                     /translation="MSASVPDDVAAAVRRITAALAVDLPVLTVEMVRLVSSEVSDLRRP
                     DIEEVMLALVRTSIGTQVDQLARSVPLELSAPSAEVVQLIRSLVHLGVSLHAVLRGFRI
                     STQFMVERWTDAVAVHGVDPRIAVEVIKAGIAEALDRAEFVTERLVEEFRDEDERRARE
                     RSLAHVEDVRRLLSGAPVDVGAAGNRLGYNLSGRHVALVVRDRSAGPADGSALDTVVRK
                     LVPPGRGLSVRIDLRTAWCWLPRPLEEPPRVPTWTEPVMVAMGCPANGLDGFRQSHRQA
                     VEAMRVAELAHRSSSTVTEYSEIALAALCSNDPEKCRDFIRTQLGGLGADDPATDRLRE
                     TLRAFYAANSNYRATAARLGLHHNTIRYRLEQVEHVLGHPVDERRLPVELALHLADILG
                     TSGAPTA"
     misc_feature    complement(21267..21269)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(22024..22038)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            22148..23149
                     /locus_tag="O3I_RS33950"
                     /old_locus_tag="O3I_033800"
     CDS             22148..23149
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-305). E-value:
                     6.3e-33. Score: 106.3. Matches aSDomain:
                     nrpspksdomains_O3I_RS33950_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="O3I_RS33950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_033800"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_014987560.1"
                     /sec_met_domain="PF00561 (E-value: 4.9e-26, bitscore: 90.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.7e-19, bitscore:
                     68.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEIEHSFVEIGDLRIHLAEQGEGPLVLLLHGFPECWYSWRHQF
                     QPLAAAGYRVVAPDQRGYARSDQPAEIEEYSLLHLAGDVIGLIHALGTEQAVVVGHDWG
                     AIVAWTVAMLRPDVVRAVAGLSVPPHLPGGCVPLATSRKRFGDKYYQVYFQQPGIADAE
                     LVQDPSASFRYILTGASGESEPRTWIVPAEGLIDPAAHAIPLPGWLSEDDIGVYVREFD
                     RHGDRAFTGALNWYRNIDRNWKLLSAFHGRRIEVPALYVGGTRDSALSARGADQVLSDL
                     EQDAPQLYSTVLLQDCGHWTQQERPDDVTTVLLRFLAHVGDSTAEHPANPLR"
     aSDomain        22223..23062
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS33950_Abhydrolase_1.1"
                     /evalue="6.30E-33"
                     /label="O3I_RS33950_Abhydrolase_1.1"
                     /locus_tag="O3I_RS33950"
                     /protein_end="305"
                     /protein_start="25"
                     /score="106.3"
                     /tool="antismash"
                     /translation="PLVLLLHGFPECWYSWRHQFQPLAAAGYRVVAPDQRGYARSDQPA
                     EIEEYSLLHLAGDVIGLIHALGTEQAVVVGHDWGAIVAWTVAMLRPDVVRAVAGLSVPP
                     HLPGGCVPLATSRKRFGDKYYQVYFQQPGIADAELVQDPSASFRYILTGASGESEPRTW
                     IVPAEGLIDPAAHAIPLPGWLSEDDIGVYVREFDRHGDRAFTGALNWYRNIDRNWKLLS
                     AFHGRRIEVPALYVGGTRDSALSARGADQVLSDLEQDAPQLYSTVLLQDCGHWTQQER"
     misc_feature    23084..23086
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(23295..23310)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     tRNA            complement(23503..23575)
                     /anticodon=(pos:complement(7643720..7643722),aa:Ala,
                     seq:ggc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="O3I_RS33955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="O3I_0t42249"
                     /product="tRNA-Ala"
     gene            complement(23503..23575)
                     /locus_tag="O3I_RS33955"
                     /old_locus_tag="O3I_0t42249"
ORIGIN
        1 tcgccgactc tccgtattgg gcgggacggg cgaccgaggt accgggtgtc ggcatcgaca
       61 tcagtcaact gctggtattc gtcggcggac acgcgatggt caccttcggt gcgccaatcg
      121 cattggtgga ggggatattc gcgcggtcgg cagcacaacc ttggctccgc cgaccgggat
      181 tggcggtgtt tggactgctc tatctgggcg ccgccagtct gttctgctac gaactcgtcg
      241 tcgtgcccgg gctggtcggc tcaccagtcc ggctcgccgg ggtgtccgcg gtcgtcgtcg
      301 tgctcgtcgt ggtggcattc gcgttaccgc gccgccccca ccgttggccc acgtcggcac
      361 gtttcgacgc cgacggaccg ggcaaatggc gcgatcgggc gccgcatccg acgttggtgg
      421 gctccctcac cgtgctgtcg gtcggtaccc atatggtgct gcgcgcaccc gagcccctcc
      481 tcggtccgct cgcctgggta tgggtggccg cctcggtcgc cccgttgacg ctcctggcct
      541 atgccctgca ccgatggtcg cggcgacgga tgtggcggcg cgcccacctc ctcgcggtcg
      601 ccttcgcacc cttgatctgc accgctctgc tggccttcgc cgtcccgccc gtgcacgacg
      661 ggaactggcc gccgaaactg atatccaaca ccgcagccct gctcattctg ctcgtcgcgt
      721 ggctgtgtgc ttcgagaatc accccgccga gccgcgagca gcaggcggca acaataaccc
      781 cgacggccgc caccggtggt catcgattcg ccaatgaagg agaagacaga tcatgaaggc
      841 attcgcagtc gccaccggga tcgttgcagt cgttctcgcc gcgtcagccc cggtcgccac
      901 ggcggcgccc caggagatcg cgatcatcaa cgggctcgtg taccaggacc agtacggtga
      961 tctcgcacgg tgcatctcgg tcgggccgat ggacatcacc gtggagaact acaccagcaa
     1021 gcgcaccgcc tacatttaca actccgacga ctgcacgggt aacccggtgg gcaccgtggc
     1081 cccgggcgcc aagggcgccg cgtacggcat aaccgtcgac ttcaagaaac cggctggcgg
     1141 cggcagcttc gaatggtgat gcccccgcac agcggacgcc agaatcacca gaaagcgcca
     1201 ggcaacccgg gcgcacgggt gaatcggccg agctgccacc tcggcacaac agtcctgaaa
     1261 acgagtgacc cgctgagctt ttcaccggcc accgggttct cgccgccgcc gagccgcgcg
     1321 gatgaacacg gccgctgaca ctcgatcgca ttcacgaagc cggggcgaca cggatgagaa
     1381 aggacggcct gcccgagatg cgtacctgct gaaggtgggt gggtgtaaat ccggcgtgga
     1441 tggcggtggc gagttcgcgg gcgtcgggga tgaggagcac cgcgattccg ttggcggtga
     1501 gcagccggcg caactcggtc cacagtggta gcgagctgtg ggagagtagc ccgcgagccg
     1561 gagcttggct gtcccacggc ggattacaga cgatgcggtc gatactgccc ggcggcaacg
     1621 gcacattcgc cgcgtcgccg agtcgggccg ggatggtggc cgcggcgttc gcgcgggttg
     1681 cccggactgc tgcggggtcg gcgtcgaagc cgcggtaggt ggctgcgggc tggagatggc
     1741 gcgcctcgag cagcagcgtg cccgcaccgc agcaggggtc gagcactcgg tcgccgggcc
     1801 gcaggtcggc cagctgcacc attgccgacg cgacgggggg atgcaggctg ccggggacgc
     1861 tctgttgttt gtagggacga cggtgcaacg ggtgcgtcgc gatgcggagc atgagacggg
     1921 catgttgccc gtccagggtc acccgccacc cgctacccga gtccggcggc cgggcaccgc
     1981 cgcgacgcga atgatagtgg agcccaagtt gttcggagag cgcaccgcct acggcgtctt
     2041 cgacgtcgta gcggttgaag tttcgccggc ccaggaacga agccgacact tcgataccac
     2101 cgccgagacc gggtggccca ccgcaccgct ccctggcttc ccacaatcga ggcacgtcca
     2161 agtccgcgac gagaccggcc aagacggcga ccgagttctt gcgccggccg atatccggcg
     2221 cggtggcggc caggacgaac gcgtcgtcag cggtccgcaa ccgcagtacc tgagaggctg
     2281 aagagagggt gtggcaatgg atttcgcgat ggccgagttc gacgacggca ccgagaccga
     2341 gccgcaggac ctccgcggcg accacggatt ccagccctcg aacacatcgc gccaccaggc
     2401 ggatgcccat gaatgtattt ctcccacaac gaggttcgga agcggcggta tgccgccccg
     2461 cctcgtcgac gacgggggga tcctcggttc gccgacggga tcctcagcgc aggaagaaga
     2521 aattcatgtc gggcatcgta acagggggaa ctggatcggt cccggcgaat ttcgcgccgg
     2581 atcacgcggc ggtcgtccaa ctgtcgctct cgaccggcgg acgccgccat cgcgtcgggg
     2641 gcacgccctc tattggcggc ggccgcggca tcggagtggc tacccatcca tctgccccgg
     2701 ccaatccagc cagcgaggat cgccctggtc gctcacgccc tgcagcacat gctggcgtcc
     2761 aggacacctt cagtcatttg tggaaccctc tccccttgtc cattctcccg aactgttcgg
     2821 tttccccagc gcgcctccgc ctcgccggag atgaaaacgg cccgatcgtc gatgtcgcgc
     2881 gtggacgact gcggttctat ctggcgcgac acccgtccta tttccccgag aatccacctg
     2941 acccagtgat tgccggaggc tgcggcgggt atcacggctc atgtcggtgc cggagggcag
     3001 ttccgggctt ccccgatgtg gccagttgcc cgtccagcgg ttcactgccg gacgggcaac
     3061 gccacccatt tcgccggccg cccgatgccg cgggcagcgc tcaggcggcg gatcggccgg
     3121 agagggtcga gcccaggcgg cgagcctgct cgtgcgactc gagcatggac gcctcgtgca
     3181 gcgcaagcag cgtcgggtcg gcaccacccg tgcagtgttc ggccaggttt gatcgagccg
     3241 aacccagcat gatgacgtag gggtcgctgt cgccgcgttt acagccgctt cgcttgccgc
     3301 cacatcacgg ctccgagcac cgcgagaaat gcggtcgaga tcgcgttaca tgccaatgcc
     3361 acaacgaaac ccgaactcgg gtgccaatcc agataggtga ccacaccccc gacggcacta
     3421 cccgtccccg cgaccgccat caagacaccg atccagcgcg gaaagctccg atccaccacg
     3481 atcgctgacc cgatcagcag gaagggaaga ccgaaagtcc atgtggccga ggcggttacc
     3541 gtgccatata gcactgcgaa caacgcgtcg gcgagctgca gattccgttc cgcctcggcg
     3601 tcggccgagg tcgcccactg atcggcgacg cgcttgaagg cgaacccatc gatggtgagt
     3661 ccaccgcgaa aatcgcagca ccgattccca tgctcagcgc cgcgaaacgg ccgaggacac
     3721 agccgagcgc ggtgcgcaac gtgcgcggca ggccataaaa ggcgcccgcc cacagcagaa
     3781 cacagagaat gcccgccaaa tgtgtgacgt accagtgtgg atgatcagcg acgaaccgga
     3841 cggccgcggt gacgtcctcg tcgggcaggt caccgtgcat cacaccgacc aagagaaacc
     3901 caccaccgcc caccatcgca caaccgccgg aaatcctcag ccaaagtcgt tgcactccag
     3961 gactattctc ggaaatgtcg tccatgaggt gaagtatcga ccgcacgtgc cactggcgac
     4021 agggagctaa caggtgaact gtccagaact ccgtcagccg tcaggggcgc tttcgctgtc
     4081 ggccctgttt tggattgccc gcggtgacca tggcgatgtg caccagccac tccaggggcc
     4141 cgcgacggaa tcgcttgcgc cacagggccg acagcgcgag gactgccacg atgaccccgc
     4201 cgaacccggc caccgagaac tgggtccggg gctcgaggac ggagtacagg aacagcaggt
     4261 gcccgacgta ccaggtcagg gtcatgctcc cggccgcgac gaggggccac agcagcgact
     4321 gcgcgcgcgg gcggtccaag agtggcagca gcagaccgag cagcagcagc gccacgccga
     4381 tcatgaaggt gatgccgacg agactggtgg cgtacggggc cgtggcgccg ggcatgtcga
     4441 acagggatcg ccaggtgagc aggtcgcctg ccggaagcag atgcggaacc agggccgcga
     4501 ccgccgacgc ggtgagtgcc agcgcgaggc cacccccagc catgcggagg cgtaccgccg
     4561 tggcgcgcag atcgaggcgg ccgatcgcga gtccggccag caccaagggg attccgtaga
     4621 cggtttggaa gccgccgccg tagcccacca aggagaaaag gtatgcggcc cagtgctgcg
     4681 gctggagaag tatcgcgggc ccgctcggga tctcggtcat cagccagctc atgtggttgt
     4741 tcatcaccca cacggcgtag agcgtcacgg ccggtacggc cgcggcggac atcagggcga
     4801 gggtccgggg tcgcagaccg gtgcagggca ccagcaggag cagcagcacc ccgtagaact
     4861 ccagcacgtt cggcgcggca ctctccaggc acagcccgat gaggaagatc atgcccgcgc
     4921 gcacggccaa ccgcctgcgc gccaggctca ttcgctggcc ggtgtacggt cgcgcaccgc
     4981 cggtcatgag cgccacggat actccggcga gcaggatgaa caggctcatg gcgcgtgagg
     5041 atgtctcgtt ctggaaccac gcgacgggtg cgggcgcggc atccggcgca ccggtctgca
     5101 gccagcccga catatggaag tgcatgagaa atacgcccag cagcgcgagc ccgcgcacgg
     5161 cgtcgacgcc gagcagccgt ggcggcgcgt gcccggtccg cggatctgtg gaagtggcga
     5221 gtgctgtcat gccggacacg gtgcccgccc gatgtgggca cttcgtggca gctgtgtcgc
     5281 ggttctgtcg caaacagtca gcgctggacc ggacaggtca gcgagccgaa gtccgggccg
     5341 atggtgggct tgatcagcac ggtggccgat gggcggcccg cttggcgatg gactcccagt
     5401 gccgtgcagg caacctgggc gatcgcgtga tcactgagtt ctgttctggt gtaaggcatg
     5461 tcgacggtga tgagggtgtc gaattcggtc accaggggag ccgggcctcc ctccgcctcc
     5521 ggtatctcgg tgtgcagtcc cgggcccggt tgcgtgcggc gcatcaggtc gagtgcctcg
     5581 ccgaccgtcc cgagtttccc ggtttcccgg aattccgggg tcacggtccc gtcggcggcg
     5641 acgaaataca gggtcacgcc cggcgcgatg ccggtcgggg cgtcgccgcc ggcgaagacg
     5701 gcgctgcccg agatcccgca gccgccgcac accgccgccg cgagcaggag cgcgaccggc
     5761 ctgattggag tccattctcg ctgtcgccca gggagtttca cggccgactc cccgctgcgg
     5821 gccgccccgg ggtccggggc aggcggacgg tgaagcgcgc gccaccggtg ggcgcacggc
     5881 ccgcggtgat gtcgccgccg tgcaggcggg cgtgctcacg ggcgatggcc aggccgagtc
     5941 cgctgccccc ggccccgccg cgcccggcgt cggccttgta gaagcgggtg aacacgcggt
     6001 cgggatcggt tgcgggcagc ccagttccgt ggtcgtcgac ggtgatcagc acgtcctcgc
     6061 ccgcggtgtg aatatccacc tgcaccggcg gtgcgccgtg cgacagcgcg ttgccgacga
     6121 ggttcgccac gatgacatcc aggcggcggc ggtccacgat cgcctcgacc ggctccatcg
     6181 cccgcagccg cactcggtcg tcgtcccaga gccgggcggc gaggctgtcc cgcaccgccg
     6241 cgacgatttc cacgtcctcg gggtgcagcc gttcggccgc ggcgtcgaag cgggagacct
     6301 cgatcaggtc cgcgaccagg gtggtgagcc gccgggtggc gtcgaccgcg agcagcgcgg
     6361 atgcccgctg gtcgccggtc atccgatcgg attcggcctc cagcacctcc accaccgcgg
     6421 tgagcgcggt gagcggcgtg cgcagctcgt gcgagacatc ggccacgaaa cggcgggact
     6481 cggcctccga ggcccgcaat cggtccaccg tcgattccag ttgtgccgcc atgtgattga
     6541 ccgtcacggt gagctcggac agctcgtcgc cgccgcgggg gttgccgcgc gcggtgagat
     6601 cgccgtcggc gagtctgcgt gcggtatccc gcaattcccg caccggccgc agcacgccgc
     6661 gcgcggccag cagcgccagc ccggccgcca ggggcaaggc cagcaggctg gtcaaggcgg
     6721 cggcgcggcc ggaatcggct atgcgggcct gcgtttcgct gagatcgcgc accgcgtaca
     6781 cctcgatgcc cgagcgcgtg cggcggccgt ccacaccggt gaccatgacg ggggtgccga
     6841 tcagcagccg cgggcctgaa atcctttgca gcatcagccc gccactgtcg cgcaccgcct
     6901 tccggagctc atcggtcacc aactcgcgat cggaatccgt tgccgcggtg aggttcccgt
     6961 aacacaccca tactcggccg ccgatcaagt cccgcaaccg gtccagggtc tgctgatcgg
     7021 gaggatcggt gagcgacggc gccgcggccg tgatgcgcgc cgccacctcg gcagcggcgc
     7081 tgttctgcgc gtcactggtc aacgaggctc gcgccgagac gaatccggcc caggccgccg
     7141 ccgccgcgcc gatcacggtg accagcacga aagcggccag cagccgggcg cgcaatccgc
     7201 gcggccatct catatcggcc cgaaccggta gccgaagccg cgcaccgtct gcacgaacag
     7261 cggcgcggcc ggatcgcctt cgatcttggc gcgcagccgc tggatcccgt tgtccaccaa
     7321 gcgcgaatcg ccgaggtaat cgtgctccca cacgcgttcg agcagctgct ggcggctgaa
     7381 aacctgcccc ggggcgccgg aaagctccag cagcagacgc agctcggtcc gcgtcagcgc
     7441 caccgcgact ccgttcttcg ccaccgtcag cccgtcacgg tcgatctcga gctccccgaa
     7501 tcgcacggtg ccgctctgca cgtcccggcc gccccggcgc agcaccgcct tgatgcgcgc
     7561 gtccaacacc cgcggcagca ccggcttgac cacgtaatcg tcggcccccg cctccagccc
     7621 acccaccacg tcgatgtcgt cctcgcgcgc ggtgagcatg atgacggcga cgtcaccccg
     7681 cgcccgcagc cgccgacaga cctcgaagcc gtccatgccg ggcagcatca catccagcac
     7741 cacgagctcg accccgtccg cggccaagga cagcccctcc tcccccgacg ccgcgacgcg
     7801 cacctcgtgg ccgtgccgcc gcagcgccat cgcgaggctg tcccggatca gcgggtcgtc
     7861 ctctatcagc aggatgcgcg ccaccgcctc atcatggcat tgccgcggcc cgccgaggcg
     7921 aacgccacgg ggccggcgca cgcacgatcg ccgccatcct caacgaccgc ggccaccgca
     7981 ccaccaccgg tgggctctgg tccacccaac aagtactacg agcgctgaac aaccgaacct
     8041 acctgggcga gaccaacttc cgcggaaaca cgaccaccga cagccacgaa tcacgggacc
     8101 ctgggcgatg aactcctcac cgaacgcctc tccagcctcc gcaccaaaac caaccaactc
     8161 cagacccgcc gcgacgagct gacctacgag atggaagaag caccccgctc acctggacct
     8221 gccacactcg acgacatcgc agaccacatc gccgaggtca tccgcgacgg caacaacaac
     8281 caaaccaaag cactcatcga agtactcatc gccgaagtca ccgtcatcgc gcccgatcga
     8341 ctcatcccga tcttccggat ccgcaaccca ccccacagga cccacccagc gcgaacaatc
     8401 cagtcgccac gacaccgcta cgcctttccc cactgtcgcg accaaacccc acgccctcca
     8461 acgactcagc gaaaccgacc gcgcgcagat catagtgacc taccaatccg gtgcatccat
     8521 caacaaactc gccaccgaat ggcaactcgc gaaaggcagc atcctcaaat tctccgcgag
     8581 aacggcacca ccatccgcac cgccctccaa cgccgcggca tctcacgccg caataccgac
     8641 ggccggactc agcagtagtt ctgccaacgt cggtttcgca ccccagggca gcacggacag
     8701 catccacaac aaaacggcac ccgccacgca gcacccgagc cgcgctggga actatccccg
     8761 gaccggttgc gccagaactc cacgaccggc cgcaacggca accaacgcgg cagagctgca
     8821 ccgccaccgt gtgcccggat gcgaccgcct catgttgagg caccggggcg tcgacctttc
     8881 gccacgccga cgtcgtccag tcgaacgaag tgtcagactt cgccatcacc ggattgctgt
     8941 agcccacgac agttctgctc actgatcccg agaagggtgg ggcgggtgag cagcagggcc
     9001 gtccggacat cgacagcacg atcccctccg acgatatgcg cggcaacgga ctttcgtggt
     9061 gggcccggcg ggtcgagcgg gtggtgtttc atggtcacgg caagtgggca agcggcgtgc
     9121 cgcgggctca tcgagttttg gttcaggtca ggcccggcga tgcatgtggt gaggccgacg
     9181 acgatatcgg tgatcctttc ctgcgcagtg catgtcacgc ccgtgggact gcgcagctac
     9241 gtaaagcagt ggcggtcaac gccttcggag tagcgatctt ctgacttaca cgaggcgagc
     9301 cggacacgaa tctgtccgtt tagtgtccgg tttgcactag tggggacggg gctatcgtct
     9361 aggtagcggg atcgagcaca gcgcgaaggt tcggggatgc catcgttgtc agccgccgaa
     9421 cggatttggg ttggtgtggt ctgtgtcggt tgcgattttc aactccggag cactgatcat
     9481 gtaggtccgt ctgaatgttg aatcccgtct gcacacggcc gagtggcgtc ccgcagcgac
     9541 gtcgcctcga cgaaaatttg attcgccagt acttttcagc ggagtcggtg tcatcgaccg
     9601 atttgagccc tcgaggggct cagaagttcg ctgccggatt cacggcggcc ggttgagact
     9661 cctcggccgc gagtgcggtg cgtgtgtcac gcatgtccgg tgagtgcgat ccgagccagc
     9721 gacgagttgc gaggtcggcg aacaggtttc acagatcttg aataccgcct accgcacgca
     9781 cactggctgg actgccagct gtcaggtgtg tggcggccac ccgtgagttt cacggcgaca
     9841 accctggcat gccgaggtgg cggtgggtcc aagagcggct agccggcgtg cgcggcagca
     9901 gtccggagtc cgtgcccggt tctcgaactc gtggacttcc gcgccgaagc ctgaaagtcg
     9961 ctgcgcgaca taagtatctg ttcttggagg attgatcgag atgacgctca ccgttcgcgc
    10021 ccggccagga cgatccgcga cagagattct tgcggaaacg cggaaggtgt tcgaaccggc
    10081 ctaccggtcg gcggttaccg cgctacctgc cgatattgcg acggtcggcg gctatcacat
    10141 cggctggtgg gacgcgcagc gaacgccgac acagctgggc gggaagtcga ttcgtcccgc
    10201 cttggtgctg gcaagcgccg ccgcgaacac ccgtggttcg gccgagctca cccgcgaacg
    10261 cgcgatcatt gccgcggtgg ccgtggagat ggtgcacgat ttctcgctgc tgcacgacga
    10321 catcatggac aacgacgaga tccgtagaca ccgctgcgcg gcatgggcga cattcggtgt
    10381 gcccgcagcc attctcaccg gcgacctgtt cctgaccgcc gcgacgaacc tgctcatctc
    10441 ccaagatcgt gacgcggcac gcatcctcat taaagcgttg cacgcgctgt gcgaggggca
    10501 aaccgaagat ctcgccttcg agaaccggcc gtcggtgtca ctgccggagt gcctgcacat
    10561 ggtcgaaggt aaaactgccg cactgttgag cgcctcgtgc gagctcggcg catgggccgc
    10621 tcacgcgggt ccagagaaag ccacgctcat gcggcaattc ggcctccagc tcggattcgc
    10681 cttccaactc gtcgacgatc tcctcggcat ctggggagac cccgagatca ccggaaaacc
    10741 ggtattcgcc gatctcgtcc atcgcaagaa gtccctgccg gtggtcgccg cactgaactc
    10801 ccacaccacc gccggtatcg aacttgcgca acgctacagc ggcaccgacc tgctcagcca
    10861 agcagagctc gaggacctcg cgcggctcat cgagctcgcc ggcggccgca gatgggccga
    10921 agacgctgcc gccgaacata tctcggctgc gcagcacctc ctcgaacaag ccgaaccgaa
    10981 tcctgcggcg gcggcggatc tgttgacgtt ggccggcctg atcacacgaa gggagcgctg
    11041 aaatgaccgg tcgtggacgt gagctggtac tcgctgcgcc gcgctcactt tgcgcgggag
    11101 tcgagcgtgc tatcgacacg atcgagcgcg tcttcctccc gcacggagcc cgcaacgccc
    11161 tactcaccga atgcggcatc tcggcacgcg gaatctgcga cctcgtctcc cgcgtactgc
    11221 cacccacgcg ggcacacgaa tcagctggga gctcgcgatg agcatcatct atctgcgcac
    11281 ccccagagcg cctctcccga tggcagcgcg gcgtgtatcg cgccgactga tggtcgggtc
    11341 tgttccggtc ggcggcggcg cgccgatttc ggtgcagtcg atgtgtacta cgagcaccgc
    11401 agacaccgac gccatcctgc agcagatcgc cgagctcact gccgccggat gtgaaatcgt
    11461 ccgagtcgcc gtcccttccc gcgacgacgc ccgggcatta cctcggatcg tcgcacgatc
    11521 acctatcccg gtcatcgccg acagcctcgg acaaacacac cgcaacggcg gggcgagagt
    11581 cctcgacacc cgaggcctcg accccgtgaa caccggtgcc gactggatac cacccaatca
    11641 cggctaagtg agctctagca acgccgttcc tcaacgggag ataacgatgc acgacagaag
    11701 cgccgcaccc acaatttcgc tgaagacccg gcggctacta tcggtgagcg cccacgaaat
    11761 acgcaccacg tgcaccctgt tctcgctgga caacacgttt atcacgcttg tacccggagt
    11821 cacctttacc gtaagcgtga gcgcagcggc ggagagccga ccagctgagt tattcaatat
    11881 agccgctggg tctatgctgt acttctttct atacggatac ttcttcaccc tctcgaacca
    11941 aatcgccgga ctggaagagg accgactgaa caagccgcac cgccctcttg tccgcggtct
    12001 tgtcgatgtt gacggcatgc gccgccgact catcggcgcc acagccgctt tcatactcac
    12061 agggtggctc ctaggagtca tagaatgggc gctcatatgg gtagcgatat cttttatgca
    12121 caaccaacta cactggtctc gaaattggat tttcaagaac ataacaatgc tggtcgggat
    12181 tatagcgatg ctcgcagcag gcgcttcact agcgaactat ctgaacgaca ccacatggcg
    12241 gtggatagtc gttatctcgg ccgcaaactt tgcattggtg tctctccagg atctgcggga
    12301 cacggcaggc gacgaagccg tgggacgacg cactttccct caatatttcg ggatcaatcg
    12361 cactcgaatc ttattggcga taggcttcat agcttatcca gccctactgc attgcacact
    12421 gtacgcagaa cctcgatact tctcgacagc aacggtgctc gaagtcatca tcgcgatatt
    12481 cagcgcgatt atatcgcttc gcatcgccac agccgagacc gcacgcgccg accatataac
    12541 gtacgtcatc tattgctatc agtactgctt gatactcgcc tccccggcac tagtgatatg
    12601 acggccaggg caccgtcagg cctccggcaa gaaaggatct ttgcaagcag cgatattaga
    12661 agcaaggcca ttattggaga agcaatgttc gaacctgcaa cgtcaccgac acgaaacagc
    12721 cagaaccgcg gtactgccgg tactcgacat agaatcagtg cgatgcacca tcagctgacg
    12781 atggagccag aaatagctat ccgcatgatg atgaccaaca ccatcagcgt ggtatttgtg
    12841 accaacatgt tcgcattgag tgcagcagta tatttcgacg tccacggcgg agaattactg
    12901 aagacgctcg cgatctcttt cgcgctatcc gttctcttct tgtacacctg ggactcgtcg
    12961 aatcaggtca gaagccgtgc ggaagactcg ataaataaac cctaccgacc attgcctacc
    13021 ggcctcgcaa ccccgcgcgg aatgctgaca agatacattc ttgctgcagc cttactcgtg
    13081 tcgttcagtc tacctttgaa tatctggctg tggtccacag gctggctcat cgctaccttt
    13141 ttcaaccatt tgatcgcgcg tccacgagac tatatttgga ccaaggtgcc caccaattgt
    13201 ctcgcgttct tctgcatgac cgctgcagca tggcggctat ccgggccgat cgactcaacc
    13261 ggctggagat ggctatgcct catgaccata tttacgtgct tacctcagat attcgaagac
    13321 ctacgagata ttcatggaga cgctgcggtc ggacgacgga caccggtagc aattttcggc
    13381 caattgccag tccggctatt tttcttcaca atggtcgcag ccactcctgt tgtcatgcac
    13441 atataccttt ggcaggacgc aacctctagc cgcaccaccc tgatggtgtg cgatgtcatg
    13501 gtcgcctcat tctcatggac caccgcgatt cgcgcactgg ctttacgatc ggtacggtcc
    13561 gacgccatta ctttccagct attcaccgta tcagtcggca tttcacttct gagtgggatc
    13621 ttcgtgtggg ctaaccgcta atttggagaa tccctgccta ttgaccaata gtgccgtaac
    13681 gtctggttcg aacctcgaat ccggcgaccc atacagtcag gattgaggcg gccgttgtgc
    13741 cacatggccg cactaccggc atcgaccgta agcgcgatgc gcgtacctct ggctcaatca
    13801 gccgaactcg ctgttgcgaa gtagcccctg gtccgaaacc gaaccggatg tgcccgccgt
    13861 ggagcaggcg caaccaggtc agcgacctga gcggtgacca tttggtcaat ttttggcatt
    13921 aagatgcacc gcttggatgt agactaacga gtttgcctgt cggtagcgtg cctggtattg
    13981 caatagcagg cggtgcgtga gctctcgggc gtgacgtcaa caccgaacca tctgcccaac
    14041 gccttatctg tcgagatgag cacggcggcc tacttgtcaa cggagattcc tggatcctgc
    14101 catgacaagt gcagcacaag agcaaacagt ttcgctgagt tgggtcagtc agagatggag
    14161 ggccagaatg tcgagatcgc ttgatgtgcc cgcgcattat gtcaccgatc gctacgtggt
    14221 cgaggcccga gacgatatcg agctcatcac cgctctgttt cggagcaggg cgtgaaagcc
    14281 gttgttctcg ccgcgggcag cggaagccga atgggcgcgc tgaccgcgac ccatccaaaa
    14341 tgcatgctgc gcatgtacgg aaccacgttg ctggagcggc aactggaagc cctggcccgc
    14401 ggtggtgcgg acgatatcgc ggtcgtgacc ggctggcgtg ctggatcttg ggaacctacc
    14461 ggtcttcggg cgttacacaa ctctctgtgg gaagagtcga cggtggtcga ttcgcttgct
    14521 gcggcgcgcg gctggctcgc tgatgagcct ttcgtcgttg catacggcga cgtcttgttc
    14581 tccgcagcaa ccgtagccgc tttgctccgg tcgttctggc ccactgcggt agcctacgat
    14641 cctgactggg agcccaagtg gcgcaagcgg ttcggcggcc cgttgatcga tgccgaaact
    14701 tttcgccatg acgcagcggg tcgactcacc gagatcggcg cacgaccccg tgacgtatcc
    14761 gagattgatg gacgctacgc cggactcatc aaattgaccc cgtcgtggtg gaccttctat
    14821 gacgaactcg gaggacgggg aatggaatta actactatgc tcggcgaact gattcgatca
    14881 aagcggctga cagtagggac agtagcgata accacgccgt ggtgggaatt cgaccaaccg
    14941 tcggatctgc ctcttggact acccgcggta cgagccctcg atgaccttgt caaaggtgca
    15001 ccgtgaacgc aatggtaatc cgtgtttcat cgatcgacat cagcgaaagc gtgcggaggt
    15061 tgcgagagga atgcgcgtaa tcgtctattc agagaccggt ccatcttcgg tgctgcgtct
    15121 tgtcgagcgg cccgatcccg caccgggacc tggtgaagtg gtggtccgca tcgtccgcgc
    15181 cggcgttaat ccagcggact gggggtttcg cgcggcaccg ggccctgtcg atggcgagct
    15241 ggcacccggc caggacggtg cgggcttcgt cgaggccgcc gggcccggtg tcgatcatgt
    15301 cgccgttggt gaccgggtat ggctgctgct ggcccagcag ggtcacggct acggtacggc
    15361 cagtgaactg accgtgcagc ccgcccaccg ggttgtcccg ctgccggaga gtgcttcttt
    15421 cgatctcggt gccgcgctcg gcgtgccgtt cctgaccgcg caccgcctgt tgacttccgg
    15481 ttcggtgacg cggctgggcc ctgcggcgct ggcggggcaa actgtgctgg tcgccggggg
    15541 cgccggcgcg gtcggcaacg ctgcgatcca gttggcgcgc tgggcagggg cgagggtgat
    15601 agcgaccgtg agctcttcca cgaaagcgag gttggcacgt gcggccggcg cgcatcacgt
    15661 gctgaattac cgagagtccg atcccgcccc ggaaatcctc gggatcgcac ccggtggggt
    15721 cgatctgatc gccgaagtcg cgccggcaca gaataatgcg ctggatctgg ccgttgcgaa
    15781 gatccacggc accgtctcga tctacgcgga caatggcggc gacacactga cgttgccact
    15841 gcgggagacc taccgcaaaa acctgcgcta ccaattcacc gtgctgcatt cccttgacac
    15901 ggcgctgttg cgggcagcca tcgatgacgt cagctccgca ctcaccgagc gggctctgcg
    15961 ggtcggggaa gacgccggtc tgccgctgca tcactacagc ttggaacaga ccgcggccgc
    16021 gcacgatgcc gtcgaacaag gcgcgatcgg caaggtcctg ctcgacctga agtaggccag
    16081 ggtctgcccg tgacggcctc acggcgtcgg cgttgcgctc ggccgccatg cagggagctg
    16141 tatgtccccg tcagacaggc ggagatccga aggatgtgtt cgtatgatca gaaagactcg
    16201 gttcggagcg gtccgcggag agacatcaga cgcggtctcc gtcttcaaag gtgtgcccta
    16261 cgccgcggca ctcgacggga agaatcggtt cctgccgccg cagccgccgc agccgtggga
    16321 tggcgttcgt ccggcgcacg ctttcagtgc cgtcccgccg cagggttcga tggcggggac
    16381 agtcggcgag tggcgaccag gcgacagcac agattgcctg accgtcaatg tgtggacccc
    16441 cgatatcggc aattctcgac taccggtgat ggtctggttt tacggcggtg ccttcaggtt
    16501 cggcgggacg agcaatcctc aatatgatgg cgcggtcctg gcccacgacg gcgtggtcgt
    16561 ggtgacggtg aactaccggg tcggctacga aggttacggc tgggtggaag attccccggc
    16621 caaccgcggg acactggacc agctcgccgc actgcactgg atccaggaca atatcgcgga
    16681 gttcggtggc gacccggaca aggtcacgat cttcggccaa tcggcaggcg ggacgtcggt
    16741 ggcgatgctg gtgtcatcac cagtatcagc tggtctcttc cagcgcgcga tagtgcagag
    16801 ccccagttcc cggttctaca gcgccgccga aagccgccgg gtgagcgagc tgattcttgc
    16861 cggaatcgga gcgcctccca ccgtcgcggc gctcaccggg gtgcctcccg agacgattca
    16921 cgcggcagag ggcgcggctc tggccgcgtt cgcggccgac ccctcggcgt ggaccgcgac
    16981 cgaggcattc acaccgtact atccggtcat cggtgacgaa gtcctgccga cgactccctg
    17041 ggcaggaatg cgcgcgggcg ccggtcgcgg ggtggacttg atcgccgggt tcaccagaga
    17101 cgagttccgg ctctatgcac accctggctc cgtgacgtcc ccagacatca cggcacactc
    17161 cgaagggctc gccaccggcg caatacaggc gtatcgggag gcacaccccg gactacctga
    17221 acccgacctg gatgttctga ttcgttccga cgcgctcttc cgaatgccat cgctctactg
    17281 cgcgcgatcc cacgctcgag ccggcggccg caccttcgcg tacgaattca ccttcccctc
    17341 gccgatcgaa ccccgcgcac tcggcgctta tcacggcatc gacgtcccgt tcatcttcgg
    17401 cagcgccaag ggggccgcag cagagctgat cgggtccgag acgaatctcg accccctgtc
    17461 acgccagata cgcacagctt ggacatcctt cgcccgcacc ggcgacccgg gatggccgca
    17521 ataccgagtc ggggaaatgc tcacccggat atggcacaac ccacccacgg tggagtccga
    17581 tccggaagcg gcgtcacgat tgatatggca atcccactat gagccataac acttgcccac
    17641 cgaaccccgg aacagccagg cgccgccaat cgctggtcct acctccactg gtcttccccc
    17701 ggtgggacgc ggcgatcatc gccagccgcc tgaggggcgg cgtgaccggt tgtcctgcat
    17761 cgcctatgcc gacaggaccg cggcgcctcg cctggggacc gccggggcac ccgccgctcg
    17821 atacgccaga tcggagcgat gcctacagac cgctcaggcg aggcaatgca ccacatggtc
    17881 gaccattagc cgagtttttg accattcgtc cctcattaat cgacgctcgg gcggatagag
    17941 ttattgccga gtgacgacgg ctgaggcgat atttttgcct gctatcggat gctcgccgac
    18001 ggtgcgcaat gaatatatga gcacccctca gagtacagcg tggtccgcta ctggtcggcc
    18061 gcgatacggt attccaagga gaaaccatga gcattgaggc cacgaccgag acgctggttc
    18121 gtgcactgga cggcagcgaa ttacagtttg ctgcggtggg atattgcgtg ggctactccg
    18181 tttgcgtaca cggtgtcctc gaactcgaga gcctgaccga ggcatttacg acgttgcaaa
    18241 ccgcaaaccc ggtgctgtca tgccgtatcg tcgcgagcgc gttggggggc gccgcactgg
    18301 cccgcgccgg cgacgcgccc tacatccgcg tccgcgacaa cgcatactcg gcgacaggct
    18361 ccaccgggat cgggcaccgc accgcgggta tcgaagtgca atacgaggac gtcgacaccg
    18421 catgggtcac cctgttgatc caccatgcga tcgccgacgc cggccacgca cttcgaatgg
    18481 tggaggattt gtggcgctac tacaccgcag caatcgacgg acgagaggtt gccgtacagc
    18541 ggcagcccta tccgcaatcg acggagttca tactgcgcca ccacggtatc gacgacgtgg
    18601 acccacggcc cgaggcggac cctgtcacag cggcgcgtga cagttcaacc actccgaaca
    18661 gcacagcggc accggtcgga ctggtgcgac tgacatccga acagacgaga gcagtcatcg
    18721 agttgggcca cgcggccggt gcgaccgtca acggactggt gtccgcagcg ctcctctgcg
    18781 cggtggccga cgccgccgaa gtcgatctcc ccgaagtgcg gtactcgttc cccgtggatt
    18841 tgcgcagtag gctcgaacca ccagtcggcc tcacagaggc gacgaacatg ctcagcatgg
    18901 cacgcttcgc tcccccgcct ggatcctcgg ccgacctgtt ggaactggcc cgagcggtaa
    18961 ccggaaaact ggcctgcgat ctcgccgacg gcagcttgac tcggtactat ttctaccctt
    19021 ccgatcaaat cgccgcctgg caggccgagt actcctaccg gccggcaacc gtgagtgcga
    19081 ccaactgggg agttataccc gaactggtga cgccggactc cctgatcgtc cgagacttcc
    19141 ggccgcatcc acaggtgacc gacccggtcg gcgcatcggt tatgacacca ctcgcaccgt
    19201 actacgtgct gttcatctac acctttcaag gacagttgtc gatcacaggc ttggcaccct
    19261 ccgcagcgga ggcggaggaa ttggccgaac tgctccggca ccagttgcat cgcctgacaa
    19321 gtctttccac ctagtcgtgt cgcacgatcg gtaaagctca gcttgaccgc ggagtaaagg
    19381 gtgccactcg taaaagacgg cgacacctgg caacgtcgaa cctcatgaac gccgggtgcg
    19441 catcggatcg gcggtcgtcg tgatcgaatt gtccacccgg atcggagctt tgatttatgt
    19501 cgacgctctg tagaagagga ggcggtgtca tggtgcagac cgttctcggc gtggtcgcaa
    19561 ggtcggtggg agccgcggtc gaggttgccg agatagtaat tccggacccc ggacccggcg
    19621 aggcggtggt ccgggtccag gcgtgcggcg tgtgccatac cgacgcgaac tatcgggacg
    19681 ggatcggcgg cggcgatttc ccgattctct tgggacacga agcgtccggc acggtagagg
    19741 cggtcggtgc ggacgtgacc gacatcgcgc cgggcgattt cgtgatcctc aactggcgtg
    19801 cggtctgcgg cgcctgccgg gcctgccggc gcggaaaatc gtggaactgt gccgcgccac
    19861 tgaccgccgg gcaacggccg accctcgccg acggcaccgc tctcacaccg gtgctcggcc
    19921 tcggggcgct ggccgagaag acgctcgtgc acgccagaca atgcacgaag gtcgaccccg
    19981 aagtcgcgcc cgcggcggcg gcgctgatcg ggtgcgggat cgcgacggga gtgggtgccg
    20041 cgttgtggac cggcgcggtc gatcgaggtg acaccgtcgc ggtgatcggg tgtgccgggg
    20101 tcggcagcgc cgcggtcgcc ggggcccgca tcgccggggc cgagaagatc atcgcggtag
    20161 acaccgaccg gcgaaggctc ggctgggcac ggacattcgg ggccacccac accgtcgacg
    20221 cacgtgccac agaaccggtg gcacgaatcc gcgaactcac cgacggtcac ggcgcggacg
    20281 tggtgatcga cgcgatcgga cggctcgaca cctggaagca ggccttctac agccgtgata
    20341 ccgcaggaac ggtcgtgctg ctcggtgtgc ccacacccga catcgtgctc gacatcccgc
    20401 tgctcgacct gcgggtcggc ggtggagcac tcaaatccgc ctggtacggc aactgcctgc
    20461 cctctcgcga cttcccgtac ctgatcggcc tgtaccggca gggccacctc gatctggacg
    20521 ctttcgtcac cgagacgatc acgctcgacc aggtagagga cgcgttccga aaattgcgca
    20581 acgaggaagt gctgcgcact gtcgtagtgc tgtgagcacg acggccatca cgcggtgggc
    20641 gcgccactgg tgccgaggat atccgccagg tgcagtgcca gttccacggg cagacgtcgt
    20701 tcgtcgaccg ggtggccgag cacgtgctcg acctgttcca ggcgatagcg aatcgtgttg
    20761 tggtgcaatc cgagccgcgc agcggtcgcc cggtagttac tgttggcggc ataaaaggcg
    20821 cgcagcgttt cgcggaggcg gtcggttgca ggatcgtccg cacccaatcc gccgagttgc
    20881 gttcgtatga agtcgcggca cttctccggg tcgttcgaac acagtgcagc caaagcgatt
    20941 tcgctgtact cggtcaccgt cgacgacgat cggtgcgcga gttcggcgac ccgcattgct
    21001 tcgacggcct gacgatgact ctgccggaat ccgtccaacc catttgcggg acaacccatc
    21061 gcgaccataa ccggttccgt ccacgtcggc acacgtggtg gctcctccag cggcctcggt
    21121 agccagcacc acgcggtgcg cagatcgatc cgcacggaaa gccctcgacc cggaggcacg
    21181 agtttgcgta cgaccgtgtc gagcgcgctt ccgtccgcag gtcccgcgct gcggtcgcgt
    21241 accacgagcg ccacgtggcg tccggataag ttgtaaccca atcgattacc ggcggcaccg
    21301 acatctaccg gagcgcccga caacaagcgg cgcacgtctt cgacatgggc cagtgagcgt
    21361 tcccgtgcgc ggcgctcgtc ttcgtcgcgg aactcctcga ccaggcgctc ggtaacgaac
    21421 tctgcgcgat cgagcgcctc cgcgataccg gctttgatca cctcgaccgc tatccgcgga
    21481 tcgaccccgt ggaccgcgac ggcgtcggtc caacgttcta ccatgaactg cgtgctgatc
    21541 ctgaagccac gcagcacggc atgcagcgaa acgccgaggt gcacgagtga ccggatcagc
    21601 tgtacgacct ccgcggaggg tgccgacaat tccaatggca cgcttcgcgc caactgatcc
    21661 acttgagttc cgatactcgt tcggacgagc gccagcatta cttcttcgat atccggccgc
    21721 cgcagatcag atacttcaga ggacaccagt cggaccattt caactgtcag caccggaagg
    21781 tcgacagcca acgcggccgt tattcggcgt acggctgccg ccacgtcatc cggcacagat
    21841 gcgctcataa cctgagcatg ccgcatcccg cgccaaatgt tcaagggtga agcgcacgaa
    21901 gcagtcaaag agtacttcgt agcacttgat gtgcgccgaa tggtcaatat cccagcggta
    21961 gtttgaccac ttgcccctgg ccgcggacag ctccggatca gtaaattcgt acacaccggg
    22021 tgctggccga ccgcctcacg cgccaggtca agaatgcgtt cgcggtaccg ccgcggagta
    22081 ttccggacct gaccgaaact gtattggccg caagaaggaa ctagccgacc gtaaccgagg
    22141 aggaagtgtg atagacgaga tagagcacag cttcgtcgag atcggcgatc tccggataca
    22201 tcttgccgag cagggagaag ggccgctggt tctgctgctg cacgggttcc cggagtgctg
    22261 gtattcgtgg cggcatcaat tccagccgtt ggccgcggcg ggatatcggg tcgtggctcc
    22321 cgatcagcgt ggctatgccc gcagtgacca gcctgccgag atcgaggagt acagcctgct
    22381 gcatctggcc ggtgacgtca tcgggctgat tcacgcgctg ggcaccgagc aggcggtggt
    22441 ggtcggacac gattggggtg ccatagtcgc ctggacggtc gccatgctgc gccccgatgt
    22501 ggtgcgggca gtggcgggtc tgagtgtgcc ccctcacctt cccggcgggt gcgtccccct
    22561 cgccacctcg cgaaagcgtt tcggcgacaa gtactatcag gtctatttcc agcaaccggg
    22621 gatcgccgac gccgaactgg tgcaggaccc ctccgccagc ttccggtata tcctgaccgg
    22681 cgcttccggc gagtccgaac cgcggacgtg gatcgtgccc gcggaggggc tcatcgaccc
    22741 ggcggcgcac gcgatcccat tgcctggctg gctgagcgag gacgatatcg gcgtatacgt
    22801 ccgggagttc gaccggcatg gtgatcgcgc cttcaccggc gcgctcaact ggtatcgaaa
    22861 tatcgaccgg aactggaaat tgctgtccgc ttttcacggc cgtcggatcg aagtcccggc
    22921 gctgtatgtc gggggtaccc gggactccgc cctgtctgcg cgcggcgcag atcaggtgct
    22981 cagcgacctc gaacaggacg ctccgcagct gtactcgact gtgctgctgc aagattgcgg
    23041 ccattggacc caacaggagc gccccgacga cgtgaccacg gtcttactgc gctttctcgc
    23101 gcatgtcggc gattcgacgg ccgagcatcc cgcgaatccc ctgcgttaac agcaccggca
    23161 cgagccggtc tgacctgtcc gggcggcccg gtcgggcagg ctgtcgacag aaaacatcta
    23221 cctgtttcgc ggcagccagt cctaccgagt ccgctgaccg actggcaaac cccgacggat
    23281 tcgttggtgt ggaccggtcg ctctcggctt cgcgacgctg agtcccgccc ctctccggaa
    23341 gatggctaac tcttgcggaa gacggatggg gttttgcgag cggtcccgaa ggtcaccgcc
    23401 atcgcgcccg atcttccgga tcccccaccc cacaggaccc gcccaaggcg gaaaatacaa
    23461 aaaccgcccc cgaagggacg gttcgtatac cgactacatc ggtggagcta aggggactcg
    23521 aacccctgac ccccacactg ccagtgtggt gcgctaccag ctgcgccata gccccgagtg
    23581 gttgctttca ggtttccctg actgcctgaa cgaagttaca ccacgggtgt ggtggcggcc
    23641 a
//
