LOCUS       NC_018681              21569 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Nocardia brasiliensis ATCC 700358, complete sequence.
ACCESSION   NC_018681
VERSION     NC_018681.1
KEYWORDS    RefSeq.
SOURCE      Nocardia brasiliensis ATCC 700358
  ORGANISM  Nocardia brasiliensis ATCC 700358
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Complete genome sequence of Nocardia brasiliensis HUJEG-1
  JOURNAL   J Bacteriol 194 (10), 2761-2762 (2012)
   PUBMED   22535940
REFERENCE   2  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-SEP-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
REFERENCE   3  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000250675.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 01:53:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,551
            CDSs (total)                      :: 8,489
            Genes (coding)                    :: 8,417
            CDSs (with protein)               :: 8,417
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 13 of 72
            Pseudo Genes (incomplete)         :: 63 of 72
            Pseudo Genes (internal stop)      :: 3 of 72
            Pseudo Genes (multiple problems)  :: 6 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:09:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6222876
            Orig. end                         :: 6244445
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003876.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21569
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="37"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21569
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21569
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11569](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11569
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(169..1689)
                     /locus_tag="O3I_RS27410"
                     /old_locus_tag="O3I_027260"
     CDS             complement(169..1689)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="O3I_RS27410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027260"
                     /product="MFS transporter"
                     /protein_id="WP_041562910.1"
                     /transl_table=11
                     /translation="MSSNVVLRDRAPAARAQPNARRGLLAVMCACVALVVGMIAATNLA
                     VPMLAAGELHPSASALIWIVDMYVIFFACLVIPGGAAGDRFGRKGVLLAGLGLFAAGAL
                     LSAVAPSVVILLVGRAITGVGAAAVLPNTLAILLHAVPADRKPATIATWASMSGLGGVI
                     GNVGGGAILSGGSWRWLFLAAVPVTLLLLGLAAKVAPVSPRHDRRIDPLGTLLLVGASV
                     ALLLGIVEGPEAGWGSGRVIAGFVCAAVLFAVWTVVELKVEHPLLDPRLFRLPRLRSAC
                     LGMTTVFFGMFALFYVNASFLQYGKGFSVLLTGLGILPLTIPMLFGARYAGRVVSRIGL
                     DATVALAFVLVGGGLLGLSTSGAQTPYFGYAAWLVVMGVGLTLALPTLSGAISGSLPHA
                     QAGVGAGLQATTREFGSALGVAVIGTVLTARFAAALPPDIRAGHNPHTVAQALSVTPPE
                     RSGDVVAAFVSSADLGLRTIGVSVLVLGALVVLESLLSRRAHPRSDAR"
     misc_feature    complement(265..267)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1276..1278)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1765..2673
                     /locus_tag="O3I_RS27415"
                     /old_locus_tag="O3I_027265"
     CDS             1765..2673
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1125: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019745041.1"
                     /locus_tag="O3I_RS27415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027265"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_014986257.1"
                     /transl_table=11
                     /translation="MPQQLDLNLLRVFDALLQDGSVTAAAERLHLSIPATSRALGRLRR
                     AMQDPILVRAGRGLAPTPFALRTAPRVRSLLDEAAALISADREITIAELERTFTIRIND
                     GVAATLATAAVEATSAVAPGVVLRFVAEGSESAEALRDGSVDLDIGASEVAAPDIRSAV
                     LYRERVVGIVRADSPLGRDGAPTLPQLCDYPHVSASRRGRQRGPLDDALAAAGLQRHVA
                     AVVPTSAVAALLVSTSHYVGLVPQRLAEEHGSALGLRWFPIPADLPDVEVRLLWHARLD
                     ADPAQRWLRDTIRAALRDDAG"
     gene            complement(2857..4194)
                     /locus_tag="O3I_RS27420"
                     /old_locus_tag="O3I_027270"
     CDS             complement(2857..4194)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (85-433). E-value:
                     3.4e-40. Score: 130.2. Matches aSDomain:
                     nrpspksdomains_O3I_RS27420_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020099995.1"
                     /locus_tag="O3I_RS27420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027270"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_014986258.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5e-38, bitscore:
                     130.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 0.00013,
                     bitscore: 20.3, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVSRYKALVDRLAADIRAGRISPGTRLPTHRELAARERLALVTA
                     TKVYAELEAMGLVSGERGRGTFVRELALPPGHGIDQRAVATDVVDLNFNYPALPGQADL
                     LRNALRQLASSGDIEALLRYQPHAGRPHERAAVARHLKRRGVPVTAEQVLIVNGAQQGL
                     AVTAMALLRPGDVVAVDALTYPGFKVLARTLHLESVPIPATEDGTDLDALARLCAARRV
                     RAVYTMPTVHNPLGWVLSLEQRERLAEIARRHGLLVIEDAAYAFSAVRPPPPVAALAPD
                     RTVYVSGLSKSVATGLRVGFVVAPPASVSALERTIRATTWNAPAVMTAIACRWLDDGTV
                     TRLETRKRADARARQAIARDVLAGLPLLGHPSAYFLWLPLPEQVRADRIVTALARKRIS
                     VSAAEPFATTRHVPHALRLALGSTDPATLRAALTTVRQVVDDHTFL"
     CDS_motif       complement(2893..2964)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O3I_RS27420_0001"
                     /evalue="5.70E-03"
                     /label="C2_DCL_024-062"
                     /locus_tag="O3I_RS27420"
                     /protein_end="434"
                     /protein_start="410"
                     /score="9.0"
                     /tool="antismash"
                     /translation="HVPHALRLALGSTDPATLRAALTT"
     aSDomain        complement(2896..3939)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS27420_Aminotran_1_2.1"
                     /evalue="3.40E-40"
                     /label="O3I_RS27420_Aminotran_1_2.1"
                     /locus_tag="O3I_RS27420"
                     /protein_end="433"
                     /protein_start="85"
                     /score="130.2"
                     /tool="antismash"
                     /translation="TDVVDLNFNYPALPGQADLLRNALRQLASSGDIEALLRYQPHAGR
                     PHERAAVARHLKRRGVPVTAEQVLIVNGAQQGLAVTAMALLRPGDVVAVDALTYPGFKV
                     LARTLHLESVPIPATEDGTDLDALARLCAARRVRAVYTMPTVHNPLGWVLSLEQRERLA
                     EIARRHGLLVIEDAAYAFSAVRPPPPVAALAPDRTVYVSGLSKSVATGLRVGFVVAPPA
                     SVSALERTIRATTWNAPAVMTAIACRWLDDGTVTRLETRKRADARARQAIARDVLAGLP
                     LLGHPSAYFLWLPLPEQVRADRIVTALARKRISVSAAEPFATTRHVPHALRLALGSTDP
                     ATLRAALT"
     misc_feature    complement(4195..4213)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.36"
                     /tool="antismash"
     misc_feature    4199..4217
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.9"
                     /tool="antismash"
     gene            4257..4895
                     /locus_tag="O3I_RS27425"
                     /old_locus_tag="O3I_027275"
     CDS             4257..4895
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003932489.1"
                     /locus_tag="O3I_RS27425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027275"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_041564442.1"
                     /transl_table=11
                     /translation="MHIAILTFEGYNELDSLIALGVLNRIKKPGRRISIACPTDRVRSM
                     NGVVIESMATLEEAAAADAVIVGSGSRTREVVEDGALMARLRLDPTRQLLAGQCSGTLI
                     LAKLGLLDDIPACTDLTTRPWVQAAGVDVLEQPLFAKGDIATAGGCLAAHYLAAWLIAR
                     LDGIDAAESALHYVAPVGEKEEYVRRAIRNIAPYLPVEPATLEATARAH"
     misc_feature    complement(4306..4321)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            4906..6345
                     /gene="proS"
                     /locus_tag="O3I_RS27430"
                     /old_locus_tag="O3I_027280"
     CDS             4906..6345
                     /EC_number="6.1.1.15"
                     /GO_function="GO:0004827 - proline-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006433 - prolyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proS"
                     /gene_functions="other (smcogs) SMCOG1162: threonyl-tRNA
                     synthetase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010908400.1"
                     /locus_tag="O3I_RS27430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027280"
                     /product="proline--tRNA ligase"
                     /protein_id="WP_014986260.1"
                     /transl_table=11
                     /translation="MARDERGVTAQSEDFASWYNEVVFKAGLVDRGPAKGTMVIRPYGY
                     RVWEHLQAELDRRIKATGHENAYFPLLIPESYLSREAEHVEGFSPELAVVTHAGGKELE
                     EPLVVRPTSETIIGEMMSKWISSHRDLPLLLNQWANVVRWELRPRMFLRTTEFLWQEGH
                     TAHAGAEDARRETMLALDIYDEVARDLAAIPVIPGEKTPGERFAGAVTTYTIEGMMRDG
                     RALQCGTSHYMGTNFATAFDIRYTGEAGREELCHTTSWGMTTRMLGAVVMTHGDDKGLV
                     FPPRLAPHQVVIVPITRGGNTAVEAAAEDLAGRLRAAGVRTHVDARAQLTPGFKYNEWE
                     LRGVPIRLELGPRDLEAGTAMMVKRLGDAGKQAVPLDSLPETMPRILDEFQAFLLARAT
                     EFRESHTRTVDTWADFADAVATGWALALHCGSTACEEDIKARTAATPRCIPLHADSASG
                     NCVRCAAPATYGKRVIFGRAY"
     gene            complement(6356..6982)
                     /locus_tag="O3I_RS27435"
                     /old_locus_tag="O3I_027285"
     CDS             complement(6356..6982)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019926248.1"
                     /locus_tag="O3I_RS27435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027285"
                     /product="LysE family translocator"
                     /protein_id="WP_171904501.1"
                     /transl_table=11
                     /translation="MSTAQALALGGVVLVAAMSPGPDFVIVTRSSVLSGRRAGMACAAG
                     IAAGVFGWSVVSALGVAGLLAASAVAFTVVKLIGAAYLMVLGVRALLAARRGGYDVTAE
                     ALANRPGTAAAFRQGLLTNLLNPKVAVFFIALLPQFLPAEPTAADSISLGVIAALVSLT
                     WFTVLANVVDALRGVLARQSVRRAIDTVMGTLLVAFGLRIALQSS"
     misc_feature    6984..7004
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.98"
                     /tool="antismash"
     gene            complement(7029..7361)
                     /locus_tag="O3I_RS27440"
                     /old_locus_tag="O3I_027290"
     CDS             complement(7029..7361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007621856.1"
                     /locus_tag="O3I_RS27440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027290"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_041564443.1"
                     /transl_table=11
                     /translation="MTTEQNISGYEWSSVQQAPVRELFPGIRVRPLWRGAQGASANVLE
                     MDPGSCWEGIDVHDPGHEEVYVVAGVFNDGDRDYPAGSFIHAPAGSSHIPQTTTGCTLF
                     VFYPEG"
     gene            7432..8379
                     /locus_tag="O3I_RS27445"
                     /old_locus_tag="O3I_027295"
     CDS             7432..8379
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007621857.1"
                     /locus_tag="O3I_RS27445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027295"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_014986263.1"
                     /transl_table=11
                     /translation="MHRVVALVHAPQSTFELSCAAEVFGLERGGLATRYTFDVCAERPG
                     PVATYAGYDMVVTAGLDELERADTVLVPGWLPTEETPSPRVVQALRDAHSRGARLVSIC
                     SGAFALAATGLLDGRRATTHWARVDELAARFPSIEVDRDVLYVDHGDVATSAGAGAGID
                     LCLHLVRTDQGAGYAAQLARSMVMPPHREGGQLQYTAPPHPTQIDGSLAPLLDWISERL
                     GEPLTVEDLAARAGVSPRTLARRFTDQLGIGPGQWLLAQRLTQARALLETTDLPVDSVA
                     RRVGLSSATNLRRRFLRALGTTPGAYRRAFRTAD"
     gene            8413..8835
                     /locus_tag="O3I_RS27450"
                     /old_locus_tag="O3I_027300"
     CDS             8413..8835
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02246.1"
                     /locus_tag="O3I_RS27450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027300"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_014986264.1"
                     /transl_table=11
                     /translation="MTDIEEARQLLDHATELWIRHEMREWGRLFTEDCDFITHRGVWWR
                     SRADNVLGHEDVPETVLAQKKNYTQTVLDIRLIAPDVVLAHTEWSWPDHVLPGAAAGED
                     RRGLVTMVLVRRGGRWLIRAAHNTRLNGLDDFASTG"
     gene            8973..9818
                     /locus_tag="O3I_RS27455"
                     /old_locus_tag="O3I_027305"
     CDS             8973..9818
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS27455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_027305"
                     /product="hypothetical protein"
                     /protein_id="WP_141692195.1"
                     /transl_table=11
                     /translation="MTRYGVALGATLIVALGACGTGDASDGASSSSPQAQQQATSASAP
                     PTTGTAPPTRDADPAEVTSGGATYTVRRVEVPNGVGTTDQAASLELSGGDARVTEVFNR
                     GVRTYVKEQVDLVNGGDDQRQRAVSTTGEIFSTDSTVSEVVSGLIVFKDAAHPTKILGT
                     ITTDSRTARPVLIGDLFTDPSAGLAELARATTEATRAVYPQLADSKTVTDALQPTERNY
                     ANWVPTPTGMQIHIDTGVYVYGYPCVQVPWSRLRPVLGPVLRAVAEQAPDTAPATCGLH
                     "
     misc_feature    9835..9849
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.05"
                     /tool="antismash"
     gene            10001..11569
                     /locus_tag="O3I_RS27460"
                     /old_locus_tag="O3I_027310"
     CDS             10001..11569
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (136-486). E-value: 5e-17.
                     Score: 54.2. Matches aSDomain:
                     nrpspksdomains_O3I_RS27460_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019046678.1"
                     /locus_tag="O3I_RS27460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027310"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_014986266.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-20, bitscore: 71.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="T1TS (E-value: 0.0047, bitscore: 15.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAHGRAGTAALAFSAMIASTMLTACGGADDPRPAASALPNTLRE
                     QVIHWHDCRTGPDDEVGRRLAAVGAVCGEFQAPLDYADPSGPALSIAVARRTATDTAHR
                     LGTLLVQTGGPGPSRDGVAILVDGPEGGHPATAALAERYDLVGMDPRFFGAGSPLDCGW
                     PTGAYLGIAQAAPRDRADFDRTVQAARDLAARCAPQRALLPHASTRAVARDTDLLRTLL
                     GEPKISYLGWSWGTYLGAVYMQLFGAHVDRVVLDSALDPAAPGPDLTRSAAPATAAALA
                     DWARWVSAHDDEFDLGTTEEAVLRAVDELVRAIAAQPIALGGLTITADMVPGLLLTVDD
                     SAEYYAEFSRQVGTLRDAARGRATDLGPGLAQKLALYAETSSTPEFGFSATVANQCADR
                     PARDPEAYFTDIQRHRDAEPMFGALARHLTPCAVWPTAPAESAVEIGNPRPALLIGAAG
                     DPVAPAAGQQAMRRALSGARSLTLANAFRHGVYLFDPAPCLDAAVDDYLLNGTLPVADA
                     VCERD"
     aSDomain        10409..11458
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS27460_Abhydrolase_1.1"
                     /evalue="5.00E-17"
                     /label="O3I_RS27460_Abhydrolase_1.1"
                     /locus_tag="O3I_RS27460"
                     /protein_end="486"
                     /protein_start="136"
                     /score="54.2"
                     /tool="antismash"
                     /translation="AALAERYDLVGMDPRFFGAGSPLDCGWPTGAYLGIAQAAPRDRAD
                     FDRTVQAARDLAARCAPQRALLPHASTRAVARDTDLLRTLLGEPKISYLGWSWGTYLGA
                     VYMQLFGAHVDRVVLDSALDPAAPGPDLTRSAAPATAAALADWARWVSAHDDEFDLGTT
                     EEAVLRAVDELVRAIAAQPIALGGLTITADMVPGLLLTVDDSAEYYAEFSRQVGTLRDA
                     ARGRATDLGPGLAQKLALYAETSSTPEFGFSATVANQCADRPARDPEAYFTDIQRHRDA
                     EPMFGALARHLTPCAVWPTAPAESAVEIGNPRPALLIGAAGDPVAPAAGQQAMRRALSG
                     ARSLTLANAF"
     gene            complement(11571..12224)
                     /locus_tag="O3I_RS27465"
                     /old_locus_tag="O3I_027315"
     CDS             complement(11571..12224)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008716274.1"
                     /locus_tag="O3I_RS27465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027315"
                     /product="response regulator transcription factor"
                     /protein_id="WP_014986267.1"
                     /transl_table=11
                     /translation="MITVLLVEDQALVRAGFRMVVDSQPDLCVIGEAGDGESGVAAAAR
                     LGPDVVVMDVRMPRLDGIAATRRLLASAHPPKVLMLTTYDLDDYAVAAVRAGASGFLLK
                     DAPPEQFLSAVRSVHAGDAVLAASTTRRLLDRLAPPIDPAARRLVATLTERETAVLRVL
                     ARGLSNAEIATVLAVGEGTVKTHVRHILTKLGVRDRVQAVIVAHEAGLRQPGSR"
     gene            complement(12221..13405)
                     /locus_tag="O3I_RS27470"
                     /old_locus_tag="O3I_027320"
     CDS             complement(12221..13405)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019046676.1"
                     /locus_tag="O3I_RS27470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027320"
                     /product="histidine kinase"
                     /protein_id="WP_014986268.1"
                     /transl_table=11
                     /translation="MVDERVVGWLRRRTALVDAGTAGLLVLVCVLFGLLIGADTAYFTL
                     SVLVLAPLAVRRRWPEAAALAVAAVAFAQWCAVRDTTGALPADIAVPIAVYTLAAHSRR
                     RWSRTGLAGGLAGAVLGGWSWPQLPMSALAHVLVGGFLASTVLAAWLGGAWQRARRGEF
                     RALAEHAALLERTRDERARLAVLSERTRIARDMHDILAHSLAVIVAQADGGRYAARATP
                     QSAIDALQAIGDQGRRALAETRRAIGVLREDTDTEPDPAPRVGVSDISTLVEEVRDAGV
                     PVDLELELPCGLTDSGVGLVVYRIVQEGLTNVVKHAGPGARAEVSVRQERNWLRVSVGD
                     DGSAGQRSGSAGYGLIGMRERVEAYGGEIELRPRTGTAGHVLTARIPVRAGRTG"
     gene            13710..14597
                     /locus_tag="O3I_RS27475"
                     /old_locus_tag="O3I_027325"
     CDS             13710..14597
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014985210.1"
                     /locus_tag="O3I_RS27475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027325"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_014986269.1"
                     /transl_table=11
                     /translation="MITEPGRFGGVDPRVADRGPTALRIAVGGQLRALREECGITREAA
                     GDYIRGSHAKISRLELGRTGFKERDILDLLTLYGVTDPDQRAVLVDLARGANQPGWWHS
                     YNDLLPSWFETYLGLEGAAQTIRTFEGQLVPGLLQTDEYTHAVIAVSHHNAEATRRVEL
                     RRRRREILDIENGPALWAVLDEAVLHRPIGGRDVLRNQIRHLVTMSAKRNVTIQVLPYR
                     AGGHPAAGSSFTMLRFTERELPDIVYLEQLTSALYLDRREDLQLYREVMDRLAVQAEQP
                     DRSRELLIAAAEAL"
     gene            complement(14602..15765)
                     /locus_tag="O3I_RS27480"
                     /old_locus_tag="O3I_027330"
     CDS             complement(14602..15765)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015368.4"
                     /locus_tag="O3I_RS27480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027330"
                     /product="hypothetical protein"
                     /protein_id="WP_014986270.1"
                     /transl_table=11
                     /translation="MRSAVALVLALTATLAVSACSSGGSDQQAGAPATPSVTATQPGRL
                     PTPTGQFAIGRDVLHLVDPARDDPWTPGTPRELMVSMYYPARAGAGAFEPYASAAEIPA
                     LLTGSALDQEIPAETLSAVRTHSVAGARPVDGTYPLVVLSPGLTAPRYTLTALAEELTS
                     RGYVVAAVDHAGESFGTEFPDGRLSTCVVCQRIEAGLPLSAVVETRVRDVTFLLDRLTG
                     AQPSWAHARMIDTDRIGMAGHSLGGAAAAAVMAADPRVRAGANMDGSFFDDTSAPGVGD
                     RPFLLFGTDAETRPGGHDSSWDRAWPALRGWKRWLTVVGADHNSFLDTPALLGADAAAT
                     PALPGHRAVEITRAYVAAFFDQHLRALPQPLLDRAAPAFPEIRSYTP"
     gene            complement(15873..16187)
                     /locus_tag="O3I_RS27485"
                     /old_locus_tag="O3I_027335"
     CDS             complement(15873..16187)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS27485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_027335"
                     /product="hypothetical protein"
                     /protein_id="WP_014986271.1"
                     /transl_table=11
                     /translation="MESPEAEILRILDRVLAVVRAAPQDLSWQARYSDEQELIDDLSDY
                     AGRLRLHDLSRLDELRFEFAPTGSLCEIAASSGWLDLYTVLGNRFDELYAQLRKPADGA
                     "
     gene            complement(16217..17071)
                     /locus_tag="O3I_RS27490"
                     /old_locus_tag="O3I_027340"
     CDS             complement(16217..17071)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013127067.1"
                     /locus_tag="O3I_RS27490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027340"
                     /product="hypothetical protein"
                     /protein_id="WP_014986272.1"
                     /transl_table=11
                     /translation="MKISRGLLIAVAALAVTIGSTATGPVPVAAAASNAEPSFEVKLNL
                     VAGALDASGAPNADVRTTFGLGGSAKALAYEYFDTAPLDLNDAGWSVRLRHKDGSSFDL
                     NYKKRFPVADGDLDAALTKANQQGFDSSDTNYDAQVDWTYDKMTLSFANKKSASAKGYQ
                     GTALPAAAEARKILVDQIPGKLQNWSGSNWGKNKLADSRPHGPVQAKSWSGSWQGADLD
                     VEVVPVRNAAGDGTETIIELSFKTDTSARASALRDQAISTLRSKGWLAPTDVLKTDLIL
                     HRY"
     misc_feature    17060..17075
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.74"
                     /tool="antismash"
     misc_feature    17062..17076
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     gene            complement(17186..18745)
                     /locus_tag="O3I_RS43045"
                     /old_locus_tag="O3I_027345"
     CDS             complement(17186..18745)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014352582.1"
                     /locus_tag="O3I_RS43045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027345"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_014986273.1"
                     /sec_met_domain="Pkinase (E-value: 2e-45, bitscore: 154.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDTFADYLVDGVLGQGGMGTVYRARHPRLPRLVALKLLHRAISE
                     DPELRRRFEQEANVVARLEHPGIVGIYDRGTQDGHLWISMQYVAGTDAARMNPRATAPA
                     QVVRLVAETADALDYAHSRGVLHRDIKPANILLAEPDSGRGPRAILTDFGIARQLDSDT
                     KLTATGTFTATLAYASPEQLSGETIDHRADQYSLACTLFTLLAGQAPFPATNPGQIIAG
                     HLAKPVPRLSDSRRDLPRALDEVIGRAMAKQRHERFATCSEFAQAAAAALHRPVAPAAR
                     LSPTMHNARPESARSEPVRAEPQRPHPQRSELQRSEPQRSESQRAEPQRPETRRATVVD
                     GDPQRRVVPTMVAHSPSAAGPGGASVYPWNMSPVGDPPPPSGATARTAAVLAGLYGLIS
                     LLPTFAAATELRSGRQRGPGFDFTFEYLALGFVGALLSVVLIFGAVALLARKRIGRTVV
                     VGGCGLAVLAALLGLAVSVANHYPIGRTFCGGGLVLFLIPLWCALAPATGRWLAYRRPA
                     RR"
     gene            18917..19735
                     /locus_tag="O3I_RS27500"
                     /old_locus_tag="O3I_027350"
     CDS             18917..19735
                     /NRPS_PKS="Domain: PKS_KR (53-164). E-value: 7.2e-11.
                     Score: 34.3. Matches aSDomain:
                     nrpspksdomains_O3I_RS27500_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011778255.1"
                     /locus_tag="O3I_RS27500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027350"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_014986274.1"
                     /transl_table=11
                     /translation="MSKIWFITGVSRGFGREWALAALGRGDRVAGTARDLSTLDDLTAR
                     YPETFLPIRLDVTDRAGDFAAVQQAAQHFGRLDVVVNNAGYGQFGMIEELTEDEFRAQF
                     ETNVFGALWVTQAALPILRAQGGGHILQVSSIGGIAAFINLGAYHASKWALEAFSQSLA
                     QEVAEFGIHVTLIEPGGFGTDWAGPSSKHATPNPAYDAARERRAAQRAVQRSGDPEATG
                     AAILAVVDADQPPLRMFLGEIPLSIATAEYESRLALWQQWQPVSAAAQGN"
     aSDomain        19076..19408
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS27500_PKS_KR.1"
                     /evalue="7.20E-11"
                     /label="O3I_RS27500_PKS_KR.1"
                     /locus_tag="O3I_RS27500"
                     /protein_end="164"
                     /protein_start="53"
                     /score="34.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="RLDVTDRAGDFAAVQQAAQHFGRLDVVVNNAGYGQFGMIEELTED
                     EFRAQFETNVFGALWVTQAALPILRAQGGGHILQVSSIGGIAAFINLGAYHASKWALEA
                     FSQSLAQ"
     gene            complement(19739..20938)
                     /locus_tag="O3I_RS27505"
                     /old_locus_tag="O3I_027355"
     CDS             complement(19739..20938)
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014983793.1"
                     /locus_tag="O3I_RS27505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027355"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_014986275.1"
                     /transl_table=11
                     /translation="MADGRSMFRTWWQDPVDYRRLVETFGSHSALGRFKFMLGAGGIVM
                     LTIAVLASIAQGDVAGPVGEVQGIVEALVAGAWTVRWWFLPWPREKESLLWIVFFDLDT
                     AANDVLVHDRVVGVLGVVLLAAIGAYVTVFHGPRVLALHIGWTLLTSVVLATLMVQGAL
                     ADNGPTTRTADLALGLAVVLVMMVVVGVMLPFIQFSHWLLRKDALSDPLTGLLNRRGLD
                     NRLPSYLGHGRRGAAYVATLDLDRFKVVNDTFGHPFGDEVLARTGERLRAAADADALIA
                     RTGGEEFVVVGYLREDPATVGERLRDALATMPGLPVRITASVGVAVLDPCHPKAVYTPA
                     LYRELLRGSDSAMYRAKRLGGNAVVLAEQNEPNSARPWRVPDRRAMADLRWHPEMLYRG
                     "
     misc_feature    complement(20129..20131)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21040..21054)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            complement(21060..21290)
                     /locus_tag="O3I_RS27510"
                     /old_locus_tag="O3I_027360"
     CDS             complement(21060..21290)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024851.4"
                     /locus_tag="O3I_RS27510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_027360"
                     /product="ferredoxin"
                     /protein_id="WP_014986276.1"
                     /transl_table=11
                     /translation="MTEQKWQITVDREQCLGSGMCVGMAPEHFTLVDGRSSPIADTVAP
                     DEFVVDAAESCPIEAIRVLAADTGEVIAPGP"
     misc_feature    complement(21249..21262)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
ORIGIN
        1 acccgcacac cgccaacacc gcctcgatcc gcctcctgga aaaccacggc ttccgccgca
       61 ccggatcgga ctggaacggc ccagacgaat acgccgtcct ggtcctcgcc tcacccgaac
      121 cccgacaact cccgtgacac ccgccgaacg atccaccggg cggagtgctc accgcgcgtc
      181 ggaccgcggg tgcgcgcgtc gggacagcag cgactccagg acgacgagcg cgccgaggac
      241 gaggacggac acgccgattg ttcgtaagcc gaggtcggcg ctcgagacga aggccgctac
      301 gacgtcgccg gatcgctcag gtggggtgac ggacagcgcc tgggctacgg tgtgcgggtt
      361 gtgcccggcg cggatgtccg gcgggagcgc ggcggcgaat cgggcggtga gcacggtgcc
      421 gatcacggcg acgccgagcg cactgccgaa ttcgcgggtg gtggcctgca atccggcgcc
      481 cactcccgcc tgggcgtgcg gtagcgaacc cgagatcgcg ccggacagcg tgggcagggc
      541 aagcgtcaat ccgacgccca tcaccaccag ccacgcggcg tagccgaagt acggcgtctg
      601 cgcgccgctg gtggacaatc cgagcagacc gccgccgacg agcacgaacg cgagcgcgac
      661 ggtggcgtcg aggccgatgc gcgacacgac ccggccggcg tagcgcgccc cgaagagcat
      721 cgggatggtg agcggcagga ttcccagtcc ggtgagcagc acgctgaatc ccttgccgta
      781 ctgcaggaac gaggcgttga cgtagaacag cgcgaacatg ccgaagaaga cggtggtcat
      841 gccgaggcag gcgctgcgca ggcgcggcag gcggaacaac cgcggatcga gcagggggtg
      901 ttcgactttc agctctacca ccgtccacac cgcgaaaaga actgccgcgc agacgaaccc
      961 cgcgatgaca cggccactcc cccagcccgc ctcgggccct tcgacgatgc cgagcaacag
     1021 cgcgaccgac gcgccgacca gcaaaagcgt gccgagcggg tcgatccggc ggtcgtgccg
     1081 cggcgaaacg ggcgccacct tggccgcgag cccgagcagc agcagggtga cgggcacggc
     1141 cgcgaggaac agccagcgcc acgatccgcc cgaaaggatc gctccgccac cgacattgcc
     1201 gatgacaccg cccagtcccg acatcgacgc ccaggtcgcg atcgtcgcgg gtttgcggtc
     1261 ggcggggacg gcgtgtaaca ggatggcgag ggtgttgggc agcacggcgg cggcgccgac
     1321 gccggtgatc gcccgcccga cgagcaggat caccacactg ggcgcgacgg ccgagagcag
     1381 cgcgcccgcc gcgaacaacc cgaggccggc gagcagtacg cccttgcgcc cgaaccgatc
     1441 tccggcggcc ccgccgggaa tgaccaagca ggcgaagaag atcacgtaca tgtcgacgat
     1501 ccagatgagc gccgaggcgg acgggtgcag ctcgcccgcg gcgagcatcg ggacggcgag
     1561 attggtcgcg gcgatcatcc cgacgacgag cgccacacag gcgcacatga cggcgagcaa
     1621 gccgcgccgc gcgttgggtt gcgcgcgggc agccggggca cgatcacgga gcacaacatt
     1681 cgatgacata gccagaacgc tagatacgca ggcagtatgc gtgccacgca acctcggcaa
     1741 caactacttg cctacgatgc aactatgcct cagcagctcg acctcaatct cctgcgcgtg
     1801 ttcgacgcgc tgctgcagga cggcagcgtc accgccgccg ccgaacgcct gcacctgtcc
     1861 attccggcga ccagccgggc gctgggccgg ctgcgccggg caatgcagga ccccatcctg
     1921 gtgcgggccg ggcgcggact ggcgccgacc ccgttcgcgc tgcgcaccgc gccgcgggtg
     1981 cgttcgctgc tcgacgaggc ggccgcgttg atcagcgccg accgcgagat cacgatcgcg
     2041 gaactggagc gcaccttcac gattcggatc aacgacggcg tggccgcgac gctggcgacg
     2101 gcagccgtcg aggccacctc ggcggtggcg cccggcgtgg tgctgcgttt cgtcgcggag
     2161 ggtagcgaga gcgccgaggc gctgcgcgac ggctcggtcg atctggacat cggcgcgagc
     2221 gaggtcgcgg cgcccgatat ccggtccgcc gtgctgtatc gcgaacgggt ggtcggcatc
     2281 gtccgcgccg acagcccgct cggccgggac ggcgcgccga ctttgccaca gctctgcgac
     2341 tatccgcacg tttccgcgtc gcgccgaggc cgtcagcgcg gcccgctcga cgacgcgctc
     2401 gccgcggccg gcctgcaacg ccatgtggcc gccgtcgtgc cgacctccgc ggtggccgcg
     2461 ttgctggtct cgacgagtca ctacgtcggc ctggtccccc agcgcctcgc cgaggagcac
     2521 ggttccgccc tcggcctgcg ctggttcccg atccccgccg acctcccgga cgtcgaggtg
     2581 cgcctgctgt ggcatgcccg cctcgacgcc gacccggccc agcgctggtt gcgcgacacg
     2641 atccgcgccg ccctccgcga cgacgcggga taatcacctg cgcgccttac cttcccggcg
     2701 gtgcggtccg acgccgcacc accgcagccg cgaccgggac tcgaaacccg cactgcccca
     2761 ggctgtgcag gcccccgccg ccgcgttcgg cgatcgtcac agtatctgtc cacagtcctg
     2821 cgcccgcctg ctgaaacaac ctgctcagca acactttcac agaaacgtgt ggtcgtcgac
     2881 gacctgtctc acggtagtga gcgcggcgcg cagggtcgcc gggtcggtcg agccgagggc
     2941 gaggcgcaag gcgtgcggga cgtgccgcgt ggtggcgaac ggctcggcgg ccgacaccga
     3001 gatacgtttg cgggcaaggg ctgtcacgat ccgatcggct cggacctgct cgggcagcgg
     3061 cagccacagg aaataggcgg acgggtggcc gagcagcggc agccccgcga gcacgtcgcg
     3121 cgcgatcgcc tgccgggctc gcgcgtcggc gcgcttgcgc gtctcgagcc gggtgacggt
     3181 gccgtcatcg agccagcggc acgcgatcgc cgtcatgacc gcgggcgcgt tccaggtggt
     3241 cgcgcggatg gtgcgttcga gcgcggacac ggacgcgggc ggggctacga cgaacccgac
     3301 gcgcagcccc gtcgcgacgc tcttggagag cccggaaacg tacacggtgc ggtcgggcgc
     3361 gagcgccgcc accggaggcg gcggccgcac cgcggagaac gcgtaggccg cgtcctcgat
     3421 gacgagaaga ccgtgccgac gggcgatttc ggcgagccgc tcgcgctgct ccagcgacag
     3481 cacccagccc agcgggttgt gcaccgtcgg catcgtatag acagcgcgca cccgtcgtgc
     3541 cgcgcacagc cgcgccagcg cgtccagatc ggtgccgtct tcggtcgccg ggatcggcac
     3601 cgattccaga tggagcgtcc gggcaaggac tttgaagccc ggataggtca gggcgtcgac
     3661 cgcgaccacg tcgccggggc gcagcagcgc catggcggtg accgccaaac cctgctgtgc
     3721 gccattgacg atcagcacct gctcggcggt caccggcaca ccgcgccgct tcaggtgccg
     3781 cgccaccgcc gcccgctcgt gcggccgccc ggcatgcggc tggtatcgca gcaatgcttc
     3841 gatatcgccg gatgacgcca actgccgcaa cgcgtttcgc agcagatccg cttggccggg
     3901 cagagccgga taattgaagt tgaggtccac cacgtcggtt gcgacggcgc gctgatcgat
     3961 gccgtggccg ggcggcagcg cgagttcgcg gacgaacgtg ccgcgccctc gctcaccgct
     4021 caccaagccc atcgcttcca gctcggcata aaccttcgtc gccgtcacca aggccagcct
     4081 ttcccgggcc gcgagttccc ggtgcgtcgg caaccgggta cccggcgata tccggcccgc
     4141 gcggatatcg gccgccaatc ggtccaccag agccttgtat cgcgagaccg ccacgctcga
     4201 attgtatgca ggacaattct ttgattgtcc tgcaaccggc gacatacggt gcccagatgc
     4261 acatcgccat tctcactttc gagggctaca acgaactcga ttcgctcatc gcgctcggcg
     4321 tactgaaccg aatcaagaag cccggtcgac gcatatcgat cgcctgccct actgaccggg
     4381 tccgttcgat gaacggcgtg gtgatcgaat ccatggccac gctcgaagag gcggctgcgg
     4441 cggacgcggt gatcgtcggc agcgggtccc gcacccgcga ggtcgtcgag gacggggcgc
     4501 tcatggcacg gctgcggctc gatccgaccc ggcagttgct ggccggacag tgttcgggga
     4561 cattgattct ggcgaaactc gggctgctcg acgatattcc cgcctgcacc gacctgacca
     4621 ccagaccgtg ggtgcaggcg gccggggtgg acgtgctcga acaaccgctg ttcgcgaaag
     4681 gcgatatcgc gacggcgggc ggctgcctcg ccgcgcacta tctcgcggcc tggctgatcg
     4741 cccggctgga cggcatcgac gcggccgaaa gcgccttgca ttacgtagcg cctgtcggcg
     4801 agaaggagga atacgtgcgc cgcgcgatac gaaacatcgc tccgtatcta ccggtggaac
     4861 cggccaccct cgaggcgact gcgcgcgccc actaatctct ggggcatggc acgggacgag
     4921 cgcggggtaa ccgcccagag tgaggatttc gcttcctggt acaacgaggt cgttttcaag
     4981 gccggcctcg tcgatcgggg tccagccaaa ggcaccatgg tcatccgacc gtatgggtac
     5041 cgggtatggg agcacctgca ggccgaactc gaccgccgca tcaaagccac cggacacgag
     5101 aacgcctact tcccgctcct gatcccggaa agctacctca gccgcgaagc cgaacacgtc
     5161 gagggatttt cgccggagct ggccgtggtc acccacgccg gcggtaaaga actcgaagaa
     5221 ccgctggtgg tacggccgac gtcggaaacc atcatcggcg agatgatgtc gaagtggatc
     5281 agctcgcacc gcgatctgcc gctgctgctc aatcagtggg ccaatgtggt gcgctgggag
     5341 ctgcggccgc gaatgttcct gcgcaccacc gaattcctgt ggcaggaggg gcacaccgcg
     5401 cacgccggcg ccgaggacgc ccggcgcgaa accatgctcg ccctcgacat ctacgacgag
     5461 gtggcccggg atctggccgc gataccggtg attccgggtg agaagacccc cggcgaacgt
     5521 ttcgcgggcg cggtcaccac gtacaccatc gagggcatga tgcgcgacgg ccgtgcactc
     5581 cagtgcggca cttcgcatta catgggcacc aacttcgcga cggccttcga catccgctac
     5641 accggcgaag cgggccggga ggagttgtgc cacaccacct cctggggcat gaccacacgc
     5701 atgctcggcg ccgtcgtgat gacgcacggc gacgacaagg ggctggtctt cccgccgcgg
     5761 ctcgcgccgc accaggtggt gatcgtcccg atcacgcgcg gcggcaacac cgccgtcgag
     5821 gcggccgccg aggacctggc gggccggctg cgggcggcgg gcgtgcgcac ccacgtcgac
     5881 gcgcgagcgc agctcacccc ggggttcaag tacaacgagt gggaactgcg cggcgtgccg
     5941 atccggctcg aactcgggcc gcgcgacctc gaggcgggca ccgccatgat ggtgaaacgc
     6001 ctcggcgacg cgggcaagca ggcggttccg ctggactcgc tgcccgagac catgccgcga
     6061 atcctggacg agttccaagc gttcctgctc gccagggcca ccgagttccg ggaaagccac
     6121 acccgcaccg tcgacacctg ggcggatttc gccgacgcgg tcgcgaccgg ctgggcgctg
     6181 gcgctgcact gcggcagcac cgcctgcgag gaggacatca aggcccgcac cgccgccacg
     6241 ccgagatgca ttcccttgca cgcggactcg gcgtccggaa actgcgtacg ctgcgccgcc
     6301 cccgcgacgt acggcaagcg cgtgatcttc ggtcgcgcct actgagcgga gcgaatcagc
     6361 tgctctgcaa cgcgattcgg aggccgaagg cgaccagcag ggtgcccatc acggtgtcga
     6421 tggcgcggcg cacactctgc cgcgccaata ccccgcgcag cgcgtcgacc acgttcgcca
     6481 gcacggtgaa ccaggtcagc gataccagtg cggcgatgac gccgagcgaa atgctgtcgg
     6541 cggcagtcgg ttcggcgggc aagaactggg gcagcagcgc gatgaagaac accgcgacct
     6601 tcggattgag caggttggtc agcagcccct gccggaacgc cgcagccgta cccggccggt
     6661 tcgccagcgc ctcggcggtc acgtcgtagc cgccgcgccg ggcggccagc agggcgcgca
     6721 cgccgagcac catcagatac gccgccccga tgagcttgac cacggtgaac gccaccgccg
     6781 acgcggcgag cagcccggcc acaccgagcg cgctcaccac cgaccagccg aagacgcccg
     6841 cggcgatccc ggccgcacag gccatcccgg cccggcgtcc cgacagcacc gaactccggg
     6901 tgacgatcac gaaatccgga cccggcgaca tcgccgccac caataccacg ccacccagag
     6961 cgagcgcctg cgctgtagac atcacctcgt caccctaacg atcacgcgag ccgccaggta
     7021 gcgggtttct aaccctccgg atagaagacg aacagggtgc acccggtcgt cgtctgcggg
     7081 atgtgcgagg aacccgcggg cgcgtggatg aacgagcccg cgggatagtc ccgatccccg
     7141 tcgttgaaga ccccggcgac cacgtagacc tcctcgtgcc cggggtcgtg cacgtcgatg
     7201 ccctcccagc agctgccggg gtccatctcg aggacgttcg cgctcgcacc ctgcgcacca
     7261 cgccacagcg gacggacccg aatgccgggg aagagttcgc gcaccggagc ctgctgcacg
     7321 ctggaccatt cgtagccgga aatgttctgc tctgtcgtca tatcgccagc ctcgcgcacc
     7381 gcgccggtcc cgccgagtgt cagcaatgac acgctggggt acttttctgc catgcaccgc
     7441 gtcgtcgccc tcgtgcacgc cccgcagtcg accttcgaac tcagttgcgc ggcagaggtc
     7501 ttcgggctcg aacgcggcgg cctcgccacg cggtacacct tcgacgtgtg cgccgagcgg
     7561 cccggccccg tggccaccta cgccggatac gacatggtgg tgaccgcggg actcgacgaa
     7621 ctcgaacgcg cggacaccgt gctcgtcccg ggctggctgc ccaccgaaga gacgccgtca
     7681 ccaagggtcg tccaggcctt gcgcgacgcg cacagtcgcg gcgcgcgcct ggtcagcatc
     7741 tgcagtggcg cgttcgcgct ggcggccacc ggtctgctgg acggacggcg cgcgaccaca
     7801 cactgggcgc gcgtggacga attggccgcc cgcttcccgt ccatcgaggt cgaccgggac
     7861 gtcctctatg tcgaccacgg tgatgtggcc accagtgcgg gcgccggcgc gggtatcgac
     7921 ctctgcctgc acctggttcg caccgatcaa ggggcgggat acgcggcaca gctcgcccgg
     7981 agcatggtca tgccgccgca ccgggagggc gggcagctgc aatacacggc gccaccgcat
     8041 cccacccaga tcgacggttc actggcaccg ctgctggact ggatctccga gcggctcggc
     8101 gaaccgctca cggtcgagga tttggccgcg cgggccggcg tctcccctcg cacgctcgct
     8161 cgccgattca ccgatcagct cggcatcggc ccaggccagt ggctgctcgc ccagcgcctc
     8221 acccaggccc gcgccctgct cgaaaccacc gacctcccag tcgattccgt cgcgcgccga
     8281 gtcggcctgt cctccgccac caacctccgc cgacgcttcc tccgcgccct cggcacgacc
     8341 cccggcgcct accgccgcgc gtttcgcacc gccgattgac ctcaaccata gttgagatcg
     8401 aacaatgggc gcatgaccga tatcgaagag gccagacagc tcctggacca cgccaccgaa
     8461 ctctggattc ggcacgagat gcgagagtgg ggacggcttt tcaccgagga ctgcgacttc
     8521 atcacacacc gcggcgtgtg gtggcgctcg cgcgcggaca acgtcctcgg acacgaggac
     8581 gtaccggaaa ccgttctggc acagaagaag aactacaccc agacggtgct cgacatccgg
     8641 ctcatcgccc cggacgtggt gctggcgcac accgagtggt cgtggcccga tcacgttctg
     8701 ccgggtgcgg ccgcgggcga ggaccggcgc ggcctggtca ccatggtgct ggtccggcgg
     8761 ggcggacgct ggctgatccg ggccgcgcac aacacacggt tgaacggact cgacgatttc
     8821 gcctcgaccg gatagtccgc gccggatcgc cgtagcctgc gacgcgcggc gggaggtttc
     8881 gggaccgtgg acgggttcgt gccggacaat gtgctgagcc agccgggtgt cgggcctcga
     8941 caccccagcg aggaggttct gtggtggggt cgatgacgag gtacggggtg gcgctggggg
     9001 cgacgctgat cgtggcgctc ggcgcgtgtg gcaccggcga cgcgagcgac ggcgcttcga
     9061 gcagttcgcc gcaggcccag caacaggcga cgagcgcgtc cgcgccgccg accaccggta
     9121 ccgcaccgcc gacccgtgat gccgatccgg ccgaggtcac ctccggcgga gcgacgtaca
     9181 cggtccggcg ggtcgaggtg cccaacggcg tcggaaccac cgatcaggcg gcttcgctgg
     9241 agctgtccgg cggcgatgcg cgggtgaccg aggtgttcaa ccgcggggtg cgtacctatg
     9301 tcaaggaaca ggtcgacctg gtgaacggcg gtgacgacca acgccaacgc gccgtctcga
     9361 ccaccggcga gatcttcagc accgacagca cggtcagcga agtggtttca ggcctcatcg
     9421 ttttcaagga cgcggcgcat cccaccaaga tcctgggcac catcaccaca gacagccgca
     9481 ccgcccggcc ggttctgatc ggcgacctgt tcaccgaccc gtccgccggt ctcgccgaat
     9541 tggccagggc caccacggaa gcgacccggg cggtgtatcc gcaactggcg gacagcaaga
     9601 ccgtcaccga cgcgctgcaa ccgacggaac gcaactacgc gaactgggtg cccaccccca
     9661 cgggcatgca gatccatatc gacaccggcg tctacgtcta cggttacccg tgcgtgcagg
     9721 tgccctggtc acggttgcgt ccggtcctcg gcccggtgct gcgagcagtg gccgagcagg
     9781 cacccgacac ggcaccggcg acctgcggtt tgcattgaac aaccaccccg atgggcacca
     9841 gatgtatgcc gaacgagtga gagcgggcgg gccgaattcg gccgtcgggt agacgccgac
     9901 cgtgggcacg aatatctagc gttcagcaga gcgcctgcca ctccggcggg ctgtcgcgtc
     9961 gccgaggtgc gatggaagct ctactgtctg tgaggtttcg atgcgcgcac acggccgtgc
    10021 cggtacggcg gcactggcgt tttcggcgat gatcgcctcg acgatgctga cggcttgtgg
    10081 cggggccgac gacccccgcc cggccgcgag cgcattgccg aatacgttgc gggaacaggt
    10141 gatccactgg cacgactgcc gtaccggacc cgacgatgag gtgggccggc gcctggcggc
    10201 ggtaggcgcg gtatgcggag agttccaggc gccgttggac tacgccgatc cgagcggtcc
    10261 agcactgtcc atcgccgtcg cgcgacgtac cgccaccgat accgcgcacc gcctgggcac
    10321 cctgctggtg cagaccggcg ggcccggacc gtcccgggac ggcgtcgcga tcctggtgga
    10381 cggacccgaa ggcggccatc cggcgacggc ggcactcgcc gaacgctacg acctggtcgg
    10441 catggacccc cggttcttcg gtgccggctc gccgctggac tgcggctggc ccaccggcgc
    10501 ctacctcggg atcgcccagg ccgcgccgcg cgaccgggcc gatttcgacc gcaccgtgca
    10561 ggcggcccgc gacctggccg ctcgctgcgc accacagcgt gccctgctcc cgcacgcgtc
    10621 gacgcgggcc gtcgcccgcg acaccgatct gctgcgcacg ctgctgggcg agccgaagat
    10681 ctcctacctc ggctggtcct ggggaaccta tctgggcgcg gtgtacatgc agctgttcgg
    10741 cgcgcacgtc gatcgggtgg tgctcgacag cgcgctggac ccggccgcac cgggcccgga
    10801 cctgaccagg tccgcggccc ccgccaccgc ggccgccctc gcggactggg cgcgctgggt
    10861 gtccgcgcac gatgacgaat tcgatttggg cacaaccgaa gaagctgtgc tacgggcggt
    10921 cgatgagctg gtccgcgcga tcgccgcgca gccgatcgca ctcggcgggc tgacgatcac
    10981 cgccgatatg gtgccgggcc tgctgctgac cgtcgacgat tccgccgagt actacgccga
    11041 gttcagcagg caggtgggca ccttgcgcga cgccgcccgc ggtcgcgcca ccgacctcgg
    11101 gccgggcctc gcgcagaagc tcgcgctgta cgccgagacc tcctcgacac ccgaattcgg
    11161 tttcagcgca acggtggcca accagtgcgc cgaccgcccc gcccgcgacc ccgaggccta
    11221 cttcaccgat attcagcggc atcgcgacgc ggaaccgatg ttcggggcgc tggcccggca
    11281 cctcacgccg tgcgcggtat ggccgacggc acccgccgaa tccgccgtcg agatcggtaa
    11341 cccgcgtccg gcgctgctca tcggcgcggc cggtgatccg gtggcaccgg cggccggaca
    11401 gcaggcgatg cgccgggccc tgtccggtgc ccgatcgctc acgctggcga acgcgttccg
    11461 ccacggcgtg tatctgttcg atccggcacc gtgcctggac gccgcggtcg acgactatct
    11521 gctgaacggc acgctccccg tggccgacgc ggtgtgcgaa cgcgactgag tcagcgcgag
    11581 ccgggctgcc gcagcccggc ttcgtgagcg acgatcaccg cctgcacccg gtcgcgcact
    11641 cctagcttgg taaggatatg gcgcacatga gttttcacgg ttccctcgcc gaccgcgagc
    11701 acggtcgcga tctcggcgtt ggacagcccc cgcgccagca cccgcagtac ggcggtctcc
    11761 cgctcggtca gcgtcgccac cagccggcgg gccgcgggat cgatcggcgg cgcgagccgg
    11821 tcgagcaggc gtctggtcgt cgaggcggcc agcaccgcgt cgccggcgtg caccgaccgc
    11881 acggcggaca ggaactgctc cggcggagcg tctttgagca ggaacccgct ggcgcccgcg
    11941 cgcacggcgg ccaccgcgta gtcgtcgaga tcgtaggtgg tcagcatcag caccttcggc
    12001 gggtgcgcgc tcgccagcag tcgccgggtg gccgcgatgc cgtccagccg cggcatgcgc
    12061 acatccatca ccacgacgtc ggggccgagc cgcgcggccg cggcgacacc gctctccccg
    12121 tcgcccgcct caccgatcac gcacagatcc ggttgggagt ccaccaccat ccggaacccg
    12181 gcccgcacca gcgcctggtc ctcgaccagc aacaccgtga tcatccggtg cgcccggccc
    12241 gcaccgggat tcgcgccgtc agcacatgcc ccgccgtccc cgtgcgcggc cggagttcga
    12301 tttcgccgcc gtaggcttcg acccgttcgc gcatgccgat caagccgtag cccgcactgc
    12361 cggaacgctg cccggccgac ccgtcgtccc cgacgctgac ccgcaaccaa ttccgttcct
    12421 gccgcaccga aacctcggcg cgcgcaccgg gtccggcgtg cttgacgacg ttggtcaacc
    12481 cctcctggac gatccggtag accaccagcc cgacccccga atcggtcagg ccgcacggca
    12541 gctcgagctc caggtccacc ggcacacccg cgtcgcggac ctcctcgacc agtgtgctga
    12601 tgtccgaaac acccacgcgc ggagccggat ccggttcggt gtcggtgtcc tcacgcagca
    12661 cgccgatggc acggcgggtc tcggccagtg cccgcctgcc ctggtcaccg atggcttgca
    12721 aggcgtcgat cgcggactgc ggggtggccc gcgcggcgta gcgaccaccg tcggcttgcg
    12781 cgacgatcac cgccagcgag tgcgcgagga tgtcgtgcat gtcgcgcgcg atcctggtgc
    12841 gctcggacag caccgcgagc cgggcccgct cgtcccgggt gcgctcgagc agggcggcgt
    12901 gttcggccag cgcgcggaat tcgccgcgcc gggcgcgctg ccacgcgccg cccagccagg
    12961 ccgcgagcac cgtgctcgcc agaaagccgc cgacgagcac gtgcgccagg gccgacatcg
    13021 gcagctgcgg ccagctccag ccgccgagca ccgccccggc cagtccccct gccaaacccg
    13081 ttcggctcca ccgtcgccgg ctgtgcgcgg cgagggtgta caccgcgatc ggcacggcga
    13141 tatcggcggg caacgcgccc gtggtgtcgc gcaccgcgca ccactgcgcg aacgccacgg
    13201 ccgccacggc gagcgccgcc gcttcgggcc accgccgccg caccgccaac ggggcgagca
    13261 ccagcaccga cagcgtgaag taggcggtat cggcaccgat cagcaacccg aacagcacac
    13321 agacgaggac gaggagcccg gccgtcccgg catccaccag cgccgtgcgc cggcgcagcc
    13381 accccaccac ccgctcgtcg accacccgac caccctagat ctcgcggcgt cgcaccacct
    13441 ctgcccgcag gatgaccctg ccgccacagt ccgtacgccg cagggcatat ccgcctcgcc
    13501 caccgctacg gtgcacaccg atagccgatc gatcgcgcgc cacgcggggc gacgcaccgg
    13561 acaaccgaat tcgccgcgga agtccagcga aagttacggt aaaactggaa cctaggggtc
    13621 tacgatcgaa aatagccacg gtttgcgtag cggtgttcag gcgcgtgcat catactgtcg
    13681 gcttttttcg agcagcggag taggagttca tgatcacgga accgggacgg ttcggcggtg
    13741 tcgacccacg ggtcgccgac cgcggaccga cggcgctgcg gatcgcggtc ggcggtcagt
    13801 tgcgcgcact gcgcgaggag tgcggcatca cgcgcgaagc cgcgggcgac tacattcgcg
    13861 gatcacacgc caagatcagc cgcctcgaac tcggccgcac cggtttcaag gaacgcgaca
    13921 tcctcgatct gctgaccctc tacggcgtca cggatccgga ccagcgcgcg gtgctggtcg
    13981 acttggcgcg cggggcgaat cagcccggct ggtggcacag ctacaacgat ctgctcccgt
    14041 cctggttcga gacctatctc ggcctcgaag gcgccgcgca gacgatcagg accttcgaag
    14101 gtcaactcgt tcccggtctg ctgcaaaccg acgagtacac gcacgcggtg atcgcggtca
    14161 gccaccacaa cgccgaggcg acccggcggg tggaactccg ccgcaggcgc cgggagatcc
    14221 tggacatcga gaacggaccg gcgctgtggg cggtgctcga cgaggccgtg ctgcatcgtc
    14281 cgatcggcgg ccgcgacgtg ctgcgcaacc agatccggca tctggtgacg atgtcggcca
    14341 agcgcaacgt gaccatccag gtgctgccct atcgggcggg cggtcacccg gccgcgggca
    14401 gctcgttcac catgctccgc ttcaccgaac gcgaactgcc cgacatcgtc tatctggaac
    14461 agctgaccag cgcgctctac ctggaccgcc gggaagacct gcagctctac cgtgaggtga
    14521 tggaccggct cgcggtgcag gccgagcagc cggatcggtc ccgtgagctg ctgatcgccg
    14581 ccgctgaggc gctgtagtcc gtcacggggt gtacgagcgg atctccggga acgcgggggc
    14641 tgcccggtcg agcagcggct gcggcagcgc gcggagatgc tgatcgaaga aggcggcgac
    14701 gtaggcgcgg gtgatctcga cggcacggtg gcccgggagt gcgggggtgg ccgcggcgtc
    14761 cgcgccgagc agcgccgggg tgtcgaggaa ggaattgtgg tcggcgccga cgacggtcag
    14821 ccagcgcttc cagccgcgca gcgcgggcca ggcgcggtcc cagctcgaat catggccgcc
    14881 ggggcgggtt tcggcgtcgg tgccgaacag caggaacggc cgatcgccga cacccggtgc
    14941 ggaagtgtcg tcgaagaagc tcccatccat gttcgccccg gctcgtaccc gtggatcggc
    15001 ggccatgacc gcggccgcgg ccgcaccgcc gagggagtga ccggccatcc cgatccggtc
    15061 ggtgtcgatc atccgtgcgt gcgcccaact cggctgcgcg ccggtgagcc gatccagcag
    15121 gaacgtcacg tcgcggaccc tggtctcgac caccgccgac agcggtaggc ctgcctcgat
    15181 gcgttggcac acaacgcaag tcgacaggcg gccgtccggg aactcggtgc cgaacgattc
    15241 gcccgcgtgg tctaccgccg cgacgacata gccacgactg gtgagttcct ccgccaacgc
    15301 ggtgagcgtg tagcgcggcg cggtgaggcc cggcgacaac acgacgaggg ggtacgtacc
    15361 gtccacgggc cgcgcgcccg cgacactgtg tgtgcgtaca gcagaaaggg tttcggcagg
    15421 gatctcttgg tcgagcgccg aacccgtgag cagcgccggg atttcggcgg cgctcgcgta
    15481 cggctcgaac gcgcccgcac cggcccgtgc cgggtagtac atgctgacca tgagttcgcg
    15541 tggggtgccg ggtgtccacg ggtcgtcccg ggcgggatcg accagatgca gcacgtcccg
    15601 tccgatcgcg aattgtccgg tgggcgtggg caaccggccg ggctgcgtgg cggtgaccga
    15661 gggggtggca ggcgcgccgg cctgctggtc cgagccaccg gacgaacagg ccgacaccgc
    15721 gagggtcgcg gtcaaggcga gcacgagggc aacggcactg cgcatggtga actccgcatc
    15781 gatcggcccg gcgcggatcg ccggtgctgc gttcgatatt caccgccgcc gcgcaaacct
    15841 ccggcagggc ggcggcaaaa tcaggtaaga actcacgcgc cgtccgccgg cttgcgcagc
    15901 tgcgcgtaaa gctcgtcgaa gcgattgccg agcaccgtgt agaggtcgag ccagccgctg
    15961 ctcgcggcga tctcgcagag cgaaccggtg ggcgcgaact cgaatcggag ctcgtccagg
    16021 cggctcaggt cgtgcagccg gagccgcccg gcgtagtcgc tcaggtcatc gatgagttct
    16081 tgttcgtccg agtagcgcgc ctgccagctc aggtcctgcg gcgccgcacg cacgacggcg
    16141 agcacgcggt cgaggatgcg cagtatctcg gcctcgggcg actccatgcc gccagcatgg
    16201 catgccgctg cgcggctcag taccggtgca ggatcaggtc ggtcttcagc acgtcggtcg
    16261 gggccagcca gcctttggac cgcaacgtac tgatcgcctg gtcgcgcaac gcgctcgccc
    16321 gcgccgaagt gtctgtcttg aaggacagtt cgatgatcgt ctcggtgccg tcacccgcgg
    16381 cgttgcgcac cggcaccacc tccacgtcga ggtcggcccc ctgccagctg ccggaccagc
    16441 tcttcgcctg gaccggaccg tgcggccggg agtccgcgag cttgttctta ccccagttcg
    16501 agccggacca gttctgcaac ttcccgggaa tctgatcgac caggatcttg cgcgcctcgg
    16561 ccgcggcggg caacgcggtg ccctgatagc ccttcgccga cgcggacttc ttgttcgcga
    16621 aactcaacgt catcttgtcg taggtccagt cgacctgcgc gtcgtagttg gtgtcggagg
    16681 agtcgaaacc ctgctggttg gccttggtca gcgcggcgtc gagatcaccg tcggcgaccg
    16741 ggaaacgctt cttgtagttg aggtcgaacg agctgccgtc cttgtgccgc aaccgcacgc
    16801 tccagcccgc gtcgttcagg tccagcggcg cggtgtcgaa gtattcatag gcgagcgcct
    16861 tggcgctgcc gccgagcccg aaggtggtgc gcacgtccgc gttcggcgcg ccggaggcgt
    16921 ccagcgcccc ggcgaccaga ttgagcttca cctcgaaact cggctccgcg ttcgaggccg
    16981 ccgccgctac cggaaccggt cccgtcgcgg tgctgccgat ggtcacggcc agtgccgcga
    17041 cagcgatgag gagaccgcgg ctgatcttca ttctcgacat catcgaagcg tgcgagcgca
    17101 aggtggccga caggcaagtg gcaggcggcc gccgcgtgaa gtctcccagg caaacacacc
    17161 gctaccctag cgagccgggc agctgtcagc ggcgagcggg acgtcgatag gcgagccatc
    17221 gaccggtcgc gggagcgagc gcgcaccaca gcggaatcag gaacaggacc agcccgccgc
    17281 cacagaacgt ccggccgatc gggtagtggt tcgccacact gaccgccaag ccgagcaacg
    17341 cggccagcac ggcgaggccg cacccaccga ccaccaccgt gcggccgatc cgcttgcgcg
    17401 ccagcaaagc cacggcaccg aagatcagta cgaccgacag caacgcgccg acgaaaccga
    17461 gcgcgaggta ttcgaaggtg aagtcgaagc cgggcccccg ctgcctgccc gaccgcagtt
    17521 cggtcgcggc ggcgaacgta ggaagcaacg agatcaagcc gtacaacccg gcgagcacgg
    17581 cggcggtccg cgcggtcgcg cccgagggcg gcggcggatc gcccaccggc gacatgttcc
    17641 aggggtagac cgaagcacca ccgggcccgg ccgcactcgg cgagtgggcg accatcgtcg
    17701 ggacgacccg acgctgcgga tcgccgtcca cgaccgtcgc ccggcgggtc tcgggacgct
    17761 gcggctcggc gcgctgggat tcagatcgct gaggttccga acgctggagt tccgaacgtt
    17821 gcgggtgcgg tcgctgcggt tctgcccgca cgggttcgga tcgcgcggac tcgggccgtg
    17881 cgttgtgcat cgtcggcgac agccgagcgg cgggtgccac gggccgatgc agcgcggcgg
    17941 ccgccgcctg cgcgaattcg ctacaggtgg cgaatctttc gtgccgctgc ttggccatgg
    18001 cgcggccgat cacctcgtcc agcgcccggg gtaggtcgcg gcggctgtcg ctgagtcgcg
    18061 gcaccggttt ggcgaggtgg cccgcgatga tctggccagg gttggtcgcg gggaacggcg
    18121 cctgtccggc cagcagtgtg aaaagcgtgc aggcgagcga atattggtcg gcgcgatgat
    18181 cgatcgtctc gccggagagc tgctcgggtg aggcgtaggc gagggtggcg gtgaacgtgc
    18241 cggtggcggt cagcttggtg tcggagtcga gctggcgggc gatgccgaaa tcggtgagga
    18301 tcgcccgcgg cccgcgcccg gagtccggtt cggccagcag gatattcgcg ggtttgatgt
    18361 cgcggtgcag cacgccgcgg ctgtgcgcgt agtcgagcgc gtcggcggtc tcggcgacga
    18421 gccgcacgac ctgcgctggc gcggtggcgc gcggattcat ccgcgccgca tcggtaccgg
    18481 cgacgtactg catggagatc cacaggtgcc cgtcctgcgt accgcgatca tagataccga
    18541 cgatgcccgg atgttccagg cgggcaacga cattggcttc ctgctcgaac cggcggcgca
    18601 gttccggatc ctccgagatc gcccgatgca gcagtttcag cgcgaccagc cggggcagcc
    18661 gcggatgccg ggcccggtac acggtgccca tcccaccctg tccgagcaca ccgtcgacga
    18721 ggtagtcggc gaatgtgtca cccaccccta acactacgat ccttcccgtc gaacgcacgc
    18781 tgatcgacgg cgagcataac gcgcgcgggc cgggcaccac ccgccgacgg cgactgaccg
    18841 gccgccgccg agtctccggc gccgtgacgc attccatcct tgcttggagt gcactccagc
    18901 tggctaccgt gcattcatga gcaaaatttg gttcatcacc ggcgtctccc gtggtttcgg
    18961 ccgagaatgg gcgcttgccg cactgggccg cggtgaccgc gtggcaggca ccgcccgcga
    19021 cctgagcacg ctcgacgatc tcaccgcccg ctaccccgag acgttcctgc cgatccggct
    19081 ggacgtcacc gatcgggcgg gcgacttcgc cgcggtacag caggccgcac agcacttcgg
    19141 ccggctcgac gtggtcgtca acaacgcggg ctacgggcag ttcggcatga tcgaggagct
    19201 gaccgaggac gagttccgcg cccagttcga gaccaacgtg ttcggcgcgc tgtgggtcac
    19261 ccaggcggcg ctgccgatcc tgcgcgccca gggcggcggc cacattctgc aggtctccag
    19321 catcggcggc atcgcggcgt tcatcaacct cggcgcgtac cacgcgtcca agtgggcgct
    19381 ggaggcgttc tcgcagtcgc tggcccagga ggtcgcggag ttcggcatcc acgtgacgct
    19441 gatcgaaccc ggcgggttcg gtaccgactg ggccggtccg tcgtccaagc acgccacccc
    19501 caacccggcc tacgacgcgg cgcgggagcg ccgggcggca cagcgggccg tgcagcgctc
    19561 cggtgatccc gaagcgaccg gcgccgcgat cctggcggtc gtcgacgcgg accagccgcc
    19621 gctgcgcatg ttcctcggcg agatcccgct gtccatcgcg accgcggaat acgagtcccg
    19681 gctcgcgctc tggcagcagt ggcagccggt ttccgctgcc gcccaaggca actgagcctc
    19741 aaccccggta cagcatctcc ggatgccacc gcaggtccgc catggcgcgc cggtccggga
    19801 cgcgccatgg ccgggccgag ttcggttcgt tctgctcggc gagtaccacg gcgttgccgc
    19861 cgagccgctt ggcccggtac atcgccgagt cggagccgcg cagcagttcg cggtagagcg
    19921 ccggggtgta gacggccttg ggatgacacg gatcgagcac cgcgacgccg acggaggccg
    19981 tgatccgcac cggcaggccc ggcatggtcg cgagcgcgtc ccgcaaccgc tcgccgaccg
    20041 tcgccgggtc ctcgcggaga tagccgacga ccacgaactc ctcgccgccg gtgcgcgcga
    20101 tcagcgcgtc ggcgtcggcg gccgcgcgta agcgttcgcc ggtgcgcgcc aggacctcgt
    20161 caccgaacgg atgcccgaag gtgtcgttga cgaccttgaa acggtccagg tccagcgtgg
    20221 cgacgtaggc ggcgccgcgg cggccgtggc cgagatacga cggcagccgg ttgtcgagcc
    20281 cgcgccggtt cagcagcccg gtcagcggat ccgagagcgc gtccttgcgc agcagccagt
    20341 gactgaactg gatgaacggc agcatcacgc cgaccacgac catcatcacc agcaccacgg
    20401 cgagaccgag ggcgagatcg gccgtgcgcg tggtcggccc gttgtccgcc agcgcgccct
    20461 ggaccatcaa cgtcgcgagc accacgctcg tcagcagcgt ccagccgata tgcagcgcga
    20521 gcacccgcgg accgtggaag acggtcacgt acgcgccgat cgcggccagc agcaccaccc
    20581 cgagcacgcc gacgacccgg tcgtgcacca gcacgtcgtt ggcggcggtg tcgagatcga
    20641 agaagacgat ccagagcagc gactccttct cccgcggcca cggcaggaac caccagcgca
    20701 ccgtccaggc gcccgcgacg agggcttcca cgatgccctg cacctcgccg accggaccgg
    20761 ccacgtcccc ctgcgcgatc gaagcgagca ccgcgatggt cagcatgacg atcccaccgg
    20821 cgccgagcat gaatttgaat cggcccagcg ccgaatggga cccgaaggtc tcgaccagtc
    20881 ggcgatagtc gaccgggtcc tgccaccacg ttcgaaacat cgatcgcccg tcggccatcg
    20941 ggtcaccgcc tcaggtcgga cttctcctgg tcatccaact cggcacgcgg atcgacagta
    21001 agacgggacc gaccgtcggc gcaacgtgag attcacccta tcgccgcagg taatcgcggt
    21061 cagggaccgg gtgcgatgac ctcgcccgtg tcggcggcca gcacccggat cgcctcgatc
    21121 gggcacgatt cggcggcgtc gacgacgaat tcgtccggag cgacggtgtc ggcgatcggg
    21181 ctggagcgtc cgtcgaccag ggtgaagtgt tcgggcgcca ttccgacgca catcccggaa
    21241 ccgaggcatt gctctcggtc gactgtgatc tgccatttct gctcggtcat gagtctcacc
    21301 agctcaccgg tagcgacttc ggcccccgca ccaggaggcc ggttttccac ggcacgtcct
    21361 cgatcggcac cgcgaggcgc aaggtcggga accgccgcag caacgagcct agcgccacct
    21421 ggagctcgac ccgggccagt tgcgcgccga ggcagtggtg cacgccgtgc ccgaaagcca
    21481 agtgcgggtt gtgctgccgg gccagatcga gggtctccgg gtcggcgaac acggcctcgt
    21541 cgcgattggc ggcctgggtg ttcacgaag
//
