LOCUS       NC_018681              22598 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Nocardia brasiliensis ATCC 700358, complete sequence.
ACCESSION   NC_018681
VERSION     NC_018681.1
KEYWORDS    RefSeq.
SOURCE      Nocardia brasiliensis ATCC 700358
  ORGANISM  Nocardia brasiliensis ATCC 700358
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Complete genome sequence of Nocardia brasiliensis HUJEG-1
  JOURNAL   J Bacteriol 194 (10), 2761-2762 (2012)
   PUBMED   22535940
REFERENCE   2  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-SEP-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
REFERENCE   3  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000250675.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 01:53:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,551
            CDSs (total)                      :: 8,489
            Genes (coding)                    :: 8,417
            CDSs (with protein)               :: 8,417
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 13 of 72
            Pseudo Genes (incomplete)         :: 63 of 72
            Pseudo Genes (internal stop)      :: 3 of 72
            Pseudo Genes (multiple problems)  :: 6 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:09:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3286022
            Orig. end                         :: 3308620
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003876.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22598
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="17"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22598
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22598
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12598](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12598
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            214..1386
                     /locus_tag="O3I_RS14880"
                     /old_locus_tag="O3I_014680"
     CDS             214..1386
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005561011.1"
                     /locus_tag="O3I_RS14880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014680"
                     /product="mandelate racemase/muconate lactonizing enzyme
                     family protein"
                     /protein_id="WP_014983752.1"
                     /transl_table=11
                     /translation="MPRIVAIHEGVVPISSSMSNAFIDFSAMDCSVVAVVSDVIREGEP
                     VVGYGFNSNGRYSAGEILRRRIIPRLLQAEPDDLRTADGQAIDPAKAWDVMLRNEKPGG
                     HGERSVAVGVVDMALFDLAAKLAGLPLYQWLVRHYGFGAPDTDVFVYAAGGYYAPGKGL
                     TQLQDEMRGFLDQGYDVVKMKIGGASLADDVKRVEAVLAVLDGDGSRLAVDANGRFDLD
                     TALAYGRALAPYGLFWYEEPGDPLDFDLHARLSGQYPGPLATGENLFSLADARNLIRYA
                     GMRPDRDYLQFDPVLGYGLVEYLRIQDMLRAHGWSPRRCIPHGGHQFSLHIAAALGLGG
                     NESYPGEFQPTGGFADAAVIEHSRIRLTDTPGIGFEDKAELYRVFRALHR"
     gene            complement(1383..1943)
                     /locus_tag="O3I_RS14885"
                     /old_locus_tag="O3I_014685"
     CDS             complement(1383..1943)
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019046976.1"
                     /locus_tag="O3I_RS14885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014685"
                     /product="TerD family protein"
                     /protein_id="WP_014983753.1"
                     /transl_table=11
                     /translation="MFTTLRDENGAALDYVTMALGWDPVRPGRWFGAPGKDIDLNASAL
                     LFAGDQIADVVYHEQLSSRDGAVRHLGDSTTGEGKGDNEIITVDLTRLSPEITAAVFIV
                     TCYTGQTFEQIENAFCRLIDSVSGIELARFDLSAGGSHTGLVMCKVYRSDGVWQFESIG
                     ETMRAEHPAEAVPLVREFLATRI"
     gene            2108..3628
                     /locus_tag="O3I_RS14890"
                     /old_locus_tag="O3I_014690"
     CDS             2108..3628
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012700.4"
                     /locus_tag="O3I_RS14890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014690"
                     /product="hypothetical protein"
                     /protein_id="WP_041562619.1"
                     /transl_table=11
                     /translation="MSRLDSILWPAGSQAAPTVDAQTVRDLNLEDIFTIVTRGDPTLAR
                     HVRAPVADLDTVTFRQEIFRDLGRAELRELFEEFAMRLRIVHAFATASAEQHHRTTGHR
                     LYLDAVVGYGSALRALSAALSTVPGTSRGLRSWQSYLETYLATNQFEELMAVATRVQAG
                     LDAVRYTLSIDGRQVVVARDDNAQDYSATVEQAFAPLVRGFRPEPAPPEILSTTVHYME
                     EQIADRVAELFPAEFAELARFCAAHPHFLAPSVESFYQELRFYLSFLEFVDHLTGEGFT
                     FSCPRLTERFEEIAVTGGYDLALAVRLRGSGQSVVPNDFRLGGSERVLVVTGPNQGGKS
                     TFARMFGQLAYLAALGCPVPAASATLLLADRLSTHFERAESVEHSAGKLHDELTEVHGA
                     IHACTARSLIIMNETFSSTTTADALQIGGAVLRRIIERGAVAVYVTFLDELASLHPAVV
                     SMVAGVGDDPSTRTFRIVRRPADGKAHAAAIADLFGLGYTAIAERIAR"
     gene            3625..5106
                     /locus_tag="O3I_RS14895"
                     /old_locus_tag="O3I_014695"
     CDS             3625..5106
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012700.4"
                     /locus_tag="O3I_RS14895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014695"
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="WP_014983755.1"
                     /transl_table=11
                     /translation="MRVGLLEPDSARAQTVRHGATVVRDLELGVVFDAMAAGDPFLRDS
                     VESIMVHASTDPATIRYRQEVLADCLADPAAVRRLYALVGASESVRRWTIGRGGAPRAK
                     LNLSLEPLAELIGHLRQVRAACAALGLRSAGFARLSALVTSSFRDEVLDAVESHVDALH
                     FEHGVALGAGLGTGNKPVGVVLHEPPRPARRGLFGGDRRARHGFTLPGQDEKGAEYLAG
                     LIGRGLSPVAEIVSHATDLITDFFLSLRTELAFYLGCVNLHERLTASGYPLCFPEPLPV
                     GRAELRCRELRDPTLVLSSGKPVGANTVDGSGRSLILVTGANSGGKSTFLRSVGLAQVL
                     LQAGMFVLADSFAADVRTGVFTHFRTQDDATMTYGRWKEELARIRDITDAIRPAALLLC
                     NEPFASTNEREGTQIGGPILRALHDAGVKIACVTHLYDLAREFYDGQTGAELFLRAERL
                     PDGTRTFRVVEGEPVATSHGGDVFRRVFGDDRMSV"
     misc_feature    4495..4497
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5164..5412
                     /locus_tag="O3I_RS14900"
                     /old_locus_tag="O3I_014700"
     CDS             5164..5412
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS14900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_014700"
                     /product="hypothetical protein"
                     /protein_id="WP_041563822.1"
                     /transl_table=11
                     /translation="MSDTNKRNLLYFESPSMRGLYEAIDEWQESAERRLLSLSIQRDGD
                     NFCCLALTNPSEVVITSPDGHNHANVSRFGTLAVDAV"
     gene            complement(5375..6034)
                     /locus_tag="O3I_RS14905"
                     /old_locus_tag="O3I_014705"
     CDS             complement(5375..6034)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014350178.1"
                     /locus_tag="O3I_RS14905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014705"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal ligand-binding domain-containing protein"
                     /protein_id="WP_014983757.1"
                     /transl_table=11
                     /translation="MPPSPADSSPRSRPGGRTARIRDQVLDAVRAELTEHGYDALTVDT
                     VAARAGVHRTTVYRRWRDVAGLITDVFAAASDLDWHPRDTGTLHGDLTALNQEIQDSLT
                     EESSIAEALIAVSFRSAAAADALQRLWEGRYTQSEIVVERAVRRGELEPGIDARALLIA
                     ATAPLYHQLILLRTPPDPGLPAHAAATAALAARAGAFTGTEGAAAKPRRRPASRTD"
     gene            6189..7796
                     /locus_tag="O3I_RS14910"
                     /old_locus_tag="O3I_014710"
     CDS             6189..7796
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014351480.1"
                     /locus_tag="O3I_RS14910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014710"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_014983758.1"
                     /transl_table=11
                     /translation="MPTQITAHAVTKSFDGRRVLDEVTCVLAAGERTGIIGENGSGKTT
                     LLRLLAGREQPDEGEIVVHAEGGIGYLAQDEYLPPQLTVQEVVDRALGELRAIEHRMRR
                     LESAMGSGDESGLAEYGELTTVFELRGGYDADARVERALHGLGLGLVGRERTVGELSGG
                     EQVRLRLAAVLAAGSEVLLLDEPTNHLDDDALTWLEDHLRTRRGTTVTVSHDRTFLERV
                     ATTLLEVDADRRRVIRYGNGYAGYLAEKAAAGERWMQAHTQWQADVDRLREFAATTARR
                     VAPGRAMKDNNKMSYDRAGGRVQQSVAGRVRNAEERLRRRLAEPVPAPPEPLRFRAALH
                     AGRTQGAVLEATDVAVEGRLERIGVTVAAGERLLITGPNGAGKSTLLRVLAGALAPDRG
                     TVLRRGRVGYLAQEPPPAAPGETLLAAFGRGRGGGADQHAEVLMSLGLFDRTRLSARVA
                     ELSTGQRQRLALARLVTEPADALLLDEPTNHLSPGLVEELEKALADYRGALVIVSHDRR
                     LRARWRGAHLALRTCVSV"
     gene            7883..8491
                     /locus_tag="O3I_RS14915"
                     /old_locus_tag="O3I_014715"
     CDS             7883..8491
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019044988.1"
                     /locus_tag="O3I_RS14915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014715"
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="WP_051066949.1"
                     /transl_table=11
                     /translation="MPGQPRVVQLRPLLTSPLIEVGDYSYYDDPDDATAFETRNVLYHY
                     GPEKLIIGKFCALGTGTRFIMNGANHRMDGPSTFPFPTMGGSWAEHFDLLTDLPNRGDT
                     IVGNDVWFGNGVTVMPGARIGHGAIISTGSVVTGAVPDYGIVGGNPARLIRTRYSDNDI
                     ARLLAVAWWDWPTAHLTAHIRTIMSGTIDDLEAAAASLD"
     gene            complement(8503..9573)
                     /locus_tag="O3I_RS14920"
                     /old_locus_tag="O3I_014720"
     CDS             complement(8503..9573)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="O3I_RS14920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014720"
                     /product="radical SAM protein"
                     /protein_id="WP_141692313.1"
                     /sec_met_domain="PF04055 (E-value: 3.2e-11, bitscore: 42.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3e-06, bitscore: 26.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVSQGPVGIIWDITYACPLRCVHCYSESGRRPTLHPARDQLFRM
                     ADAFLSLQPQEVAIAGGEPLLVDGVFEIAERFTQAGISVILYTSGLPVDAHKAEESLRH
                     FSTVAVSMDGATADVHDRIRGRARAFERGLAAVQLLDGTARRMKAEGQDPGTLGIEVSI
                     MRSNLHQVEEFCTTIAPRFPELRHLVFTVTMPAGLANRPGFVDHELLDDAESQRLLSPE
                     YLAHLRDLAPAGLDIRIDDHWHDMIHPDHVAEGSVLPIMHVRPDGEVHAMPIYEGTVGS
                     VLDEPPMVLWERALARWSDPFVVQTLAPVRTMRDWAEAARRLDHHFAAPVDRARLDRRP
                     AFLPLAVPTASKAPVA"
     misc_feature    complement(9514..9516)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9696..9712
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.85"
                     /tool="antismash"
     gene            9775..9906
                     /locus_tag="O3I_RS46790"
     CDS             9775..9906
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS46790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_272944297.1"
                     /transl_table=11
                     /translation="MEREIEQLSTDVAALQTLPERDHGAGAVIWPDPTRGSACRGDQ"
     gene            10001..12598
                     /gene="lanL"
                     /locus_tag="O3I_RS14925"
                     /old_locus_tag="O3I_014725"
     CDS             10001..12598
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="O3I_RS14925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014725"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_014983761.1"
                     /sec_met_domain="Pkinase (E-value: 5.3e-15, bitscore: 54.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-44, bitscore:
                     151.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNPVAEATLVELAQRHLAGRSDRRIWTDGVWCHLSPVNYRWPRQ
                     GWKLHIAATVGSAATVLDRTLDIVLRTECSGKFAASLEQVRRLNSADYPRGGAGKFITV
                     YPRDDAQLRVLAALLHEATAGLAGPAILSDRPYAAGSLVHYRYGEFLGEDVIGGSGDYL
                     PMLTAPDGSRVEDRRDAWFAPPVWADDPFGRPRSTEKATSGVLLANRFEVRRAIVHANK
                     GGVFEATDRLTGAEVVVKQARAGVGDGPHGWNVQDALRNEAEMLDLLSPLAPRRLALFE
                     QQHDLFLVQEMIAGTTFLEWRGRRHGALDWRATALRLTELLAAVHARGVVLQDFSASNV
                     MVRPDDSLVLVDLEFAGRSGAIRMTGWTPDYAAPEQISGAAADFAADRHALGALLFLLC
                     LGAKPSFAPDDRPARSKAARIARLLELAAETDREIATARPLLLGLLADDPAERWSLDRV
                     HGFLTGDHQDPPRRRARHRTTDIDRLLDDGVGYLLNTMTPAGERLWPVSDGGKRSDPCN
                     VYHGAAGVLATLTRVAEVRRDARVLAALPIAADWIIDRTTARNPVPGLYIGRSGTAVAL
                     CAAGRVLDSERLVRVGTQLFGEVPRDWPNNDVTHGLAGAGYAALLLWSATGRTEFRDRA
                     AEYAAVLTERAERRDGVLVWPVPHDYDSRYAGSVDYGFAHGTAGIGAFLLAAGSRLDEP
                     RWLELAAEAAESLCGAAVPTDVGALWPIGPRDTTRLLDHWCSGSAGIGTFLLQYWQASG
                     DRQARSWAERAAEAVGARRWRAGATLCHGLAGSGELLLDLCAATGDERARVRAEGIAAA
                     LAVRAGRHRGHLLAADETGSGYGADYAVGVAGWVDFLLRLKHGNPRAWLVGPR"
     misc_feature    complement(12660..12678)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            12677..14224
                     /locus_tag="O3I_RS14930"
                     /old_locus_tag="O3I_014730"
     CDS             12677..14224
                     /GO_function="GO:0008484 - sulfuric ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013080.4"
                     /locus_tag="O3I_RS14930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014730"
                     /product="sulfatase-like hydrolase/transferase"
                     /protein_id="WP_141692314.1"
                     /transl_table=11
                     /translation="MNVADSARPETPVRRLDRRRVLGMMAAAPVAVPLLRAAAATAAPR
                     SRPNILVLMTDQERADVVLPAGFELPTRARLAANGVRFAMHHTPTAPCSPARSTLFTGL
                     HAPVSGMLDNVRGNDLMGTVLGAIQTWSPDLDSAVPTLGTVLRAAGYHTTYIGKWHLSD
                     EVAADPAALSGYGFDEAHDILAAGGPNEGTRQDPGVVGHAVDWLQRHGGDPDPWLCVVS
                     MVNPHDMMFCPRLYRFEDVPEYGADVPPNFESDLTTKPRVQSRWRTINGIVGGPMPTEL
                     DSPDARRQWQRWGNWYLELLRRTDELSGQVLAAVERSGAADNTVVVQVADHGELGGAHG
                     LRQKGAMIYRENNRVPLVIADPRAPAGHGRTANALTSHIDLVPTLAALAGIDGAAAGSG
                     PGRNLVPVLADPARTVRDAILLTSDAKSSGGQLPGSRYCLRGAITARYSFGRYSTPEQL
                     GGPRGEFEYELYDRQVDPLELHNLAHGGGAAGLVEDLNDLVDSLLARELRRPDTETR"
     gene            complement(14264..15496)
                     /locus_tag="O3I_RS14935"
                     /old_locus_tag="O3I_014735"
     CDS             complement(14264..15496)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.4"
                     /locus_tag="O3I_RS14935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014735"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_014983763.1"
                     /transl_table=11
                     /translation="MYQLTARDIRRRNRFGVLQAVYAADGHISRQDIARATGLSFATVG
                     NMIAELLDVGVLVELGHDAPGVGRPRARLAINPDRGLLVGVDIAETAIHFDLFDLAMTA
                     LRAVEIPVDPAATEPHDVAALIIRGIRELTAGDADKVLGAGLSVPGLVEPEGGISVFSP
                     YWHWHDVPLKELLDDQLPHPLYLDNPLKASTAAHLWFGAGRDVDDLIVVTLRAGVGIGV
                     VVDGMLYRGVSNSAGEWGHTNLVLDGRECRCGRTGCVEAYVGAPGIVRTLRELDPASPM
                     LASDDAATIAAIAAAAGREDPVALAVIDRTGHYLGVAVANLVNLFNPRTMVFGDLVADH
                     LGPPLLEVTRRVAAHHAMTDPFDAVTLQLSALPHNPASLGAATFALDGFLADRETFGSI
                     AARRALRTSAT"
     misc_feature    15582..15597
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.2"
                     /tool="antismash"
     gene            15636..16685
                     /locus_tag="O3I_RS14940"
                     /old_locus_tag="O3I_014740"
     CDS             15636..16685
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024799.4"
                     /locus_tag="O3I_RS14940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014740"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_014983764.1"
                     /transl_table=11
                     /translation="MSWTHRRRWTSAVLCGISLALAATACSSGKESASPAAGPQQQTGA
                     ISLVYAQKQGDQEYFIGEAEGAKAKAKELGIDLKVVNLGNDANKAVTEVNNAINQKASG
                     VIVVVPDPSVGPQVAQLTKTGGVALLTSDDQVCTTGPDPSKCAKDQLVPRVGFSGTQMG
                     TEVGRRAGQDFKKAGWKPEETAIVEAWKQDVTVCTDRVEANKKAFREAAGVDVRVIEVG
                     TDNTPSDAQNKISATVAGNRSVKNWIVMGCNDENVSGGVAAIQNAGYAADNVLGVGLGA
                     YLACKEWRGGKPTGFKAALFINGKDVGALAVQTMHDYLKNGKAMPAEAFAPTTMVDASN
                     WQQAGVTCS"
     gene            16676..18190
                     /locus_tag="O3I_RS14945"
                     /old_locus_tag="O3I_014745"
     CDS             16676..18190
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="O3I_RS14945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014745"
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_014983765.1"
                     /transl_table=11
                     /translation="MQLSGLRATGLSKSFAGVPALREVSLDFPAGAVTALMGENGAGKS
                     TLIRILGGDHRPDSGRLELDGVLLDQATPAAARAAGIRVIGQEPEIVPHVSVAENVYLG
                     ALPRRAGRLLDRAALHERMRTDLARLGFDRDLDPSTVGSKLTAAQRQLVEIMRALTTDA
                     KVIAFDEPTSSLSDHETESLFALIGRLRERGLAVIYVSHRMREIFRLADRVAVLRDGAL
                     VGVRATAETTDQEIVRMMVGRDLSTLFARGPAAPGRVVLDVDAVTTDDVSDVSLQVRAG
                     EVVALAGLVGAGRSELAGALAGDLPIRSGTVRIDGKPVRLRQPRDAVRAGVGYAPEERK
                     AQALLLHRGVRDNISLAMLDRLRRLRFVKAGAERRLAQQYVASLRVRTPSIEQEVRKLS
                     GGNQQKVVLARWLARKPKVLILDEPTRGVDVGAKAEIYRIIEELAEAGVAVLVISSELP
                     EVLGLADRIVVMQQGRVTGELDRGAASEEAVLALAMAADLTSLGNQ"
     gene            18187..19245
                     /locus_tag="O3I_RS14950"
                     /old_locus_tag="O3I_014750"
     CDS             18187..19245
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014684.4"
                     /locus_tag="O3I_RS14950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014750"
                     /product="ABC transporter permease"
                     /protein_id="WP_014983766.1"
                     /transl_table=11
                     /translation="MTEQQLTAVPVAPANPQAPERNRYAAAFTPRRILHAIGPGNLSLI
                     GALAVIVAIFGSLNDGYLDPANLAGIGDAVTVFGLLAVVQTVVIICGALDISVGSQAGV
                     ASVLSAMAFTATSGNAFLGILAAIGIGLVLGLVNGLIIVYGRVNPVIATLATLAAYKGL
                     AQLISGGKAQGFVLDNDVFIFLARGKIIGLPVPVIILAIVAVAVHVLLKYTDIGRNIYA
                     IGGNDTAARLSGININKYLIAVFVLAGVVAAIAGIILTARTGSGQPVSGSEGLELKAIT
                     AAALGGCALKGGKGTVGGTLLAVVLLGALDNGLNVVGVNTFWQNVAQGSLLVAAVVIQQ
                     RRSGERAVGLPT"
     gene            19281..20180
                     /locus_tag="O3I_RS14955"
                     /old_locus_tag="O3I_014755"
     CDS             19281..20180
                     /EC_number="3.1.1.99"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020039.4"
                     /locus_tag="O3I_RS14955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014755"
                     /product="SMP-30/gluconolactonase/LRE family protein"
                     /protein_id="WP_014983767.1"
                     /transl_table=11
                     /translation="MISLRAQPCTPAPGHLCESPVWDSRTQELLWVDIRGGHIHRATLD
                     RATLDLTHRSTVSLAPPVSAVVPCLSGGLLATAKDTIYRIDHGEVTRVAGIPLPDDGNR
                     RRFNDAKVDPRGRLLAGTMSEDGVARSAALYRLDPDGAMSILREGVTISNGLGWSPDGA
                     TFYYADSPTQRVDAFDYDLDTGTFTGRRTFARFEDGDPDGLTVDAAGWVWVAVWGAGQV
                     RAFDPDGEPRAVVDVGPSQVSSCVFAGPELDVLVITTAAEGPAVLEPDSGRLFTCVPGA
                     VGLPGVPYADTTLVRNHG"
     gene            20173..20784
                     /locus_tag="O3I_RS14960"
                     /old_locus_tag="O3I_014760"
     CDS             20173..20784
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013263.4"
                     /locus_tag="O3I_RS14960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014760"
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="WP_014983768.1"
                     /transl_table=11
                     /translation="MAEDPLELATPVIAILRAPTAQRFAEVTAVLHESGITAVEFTLTS
                     AGALDAIRACAGFAYRIGAGTVRTAADAARAVDAGAAYLITPIVSEEVIAAGLDLGVPV
                     ISGAFTPTEIHRAWTAGSTMVKLFPAASGGPGYLRAVRAPLPEIPLVPTGGVGLGEAQA
                     YLDAGATALGIGSPLIGDACAGGDLDALRERVSVLRAGLS"
     gene            20814..21758
                     /locus_tag="O3I_RS14965"
                     /old_locus_tag="O3I_014765"
     CDS             20814..21758
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012515.4"
                     /locus_tag="O3I_RS14965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014765"
                     /product="sugar kinase"
                     /protein_id="WP_041562622.1"
                     /transl_table=11
                     /translation="MRGTLVTLGEAVGVVAAVEPGPLAPGAALRMDFAGAEATVAIGVS
                     RLGHHSVWVGSVGDDAVGTMVLDRLRAERVDVSGCRIDPELPSGLMVRERRTADHIRAT
                     YYRRGLAGSRLSVAQVDTEQIAAAGVLHLTGITPALSACARDAVHAALDAAVEAGVPVS
                     LDINYRSALWSRADAAAELAKLVSHCDIVFAGLDEAALLVPSASASAMAESLAALGPSQ
                     VVLKLGGDGALALHRGRVIRQQAIPVTMVDPVGAGDAFVAGYLAGVLDGTSVRHNLRLA
                     ATCGAFAVSVPGDWAGLPSRRELDLLNGTDIQR"
     gene            21770..22525
                     /locus_tag="O3I_RS14970"
                     /old_locus_tag="O3I_014770"
     CDS             21770..22525
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-167). E-value: 6.6e-13. Score:
                     40.9. Matches aSDomain:
                     nrpspksdomains_O3I_RS14970_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003895451.1"
                     /locus_tag="O3I_RS14970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014770"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_014983770.1"
                     /sec_met_domain="adh_short (E-value: 3e-32, bitscore:
                     111.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 8.9e-30, bitscore:
                     103.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLAERVAVVTGGASGIGAATASRLAAEGAAVVIADIAEPAGEE
                     VAAKIRAAGQRAEFVWCDVSQEQSWVWLHNRVNEVFGPLDVLCSNASRQAPIPADELSR
                     RQWDDGLAINLTPLFLGVHTFIDDLRSQAGNVVAISSVHAQFGLPGYPVYAAAKGGLTA
                     LVRQLAVEYGGARVRFNAILPGPVLTPVWDDVDEEGRRLSARATVLDRLGAPEEVAAAV
                     AFLASDDASFITGANLVVDGGWSVRKESR"
     aSDomain        21791..22270
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS14970_PKS_KR.1"
                     /evalue="6.60E-13"
                     /label="O3I_RS14970_PKS_KR.1"
                     /locus_tag="O3I_RS14970"
                     /protein_end="167"
                     /protein_start="7"
                     /score="40.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGGASGIGAATASRLAAEGAAVVIADIAEPAGEEVAAKIRA
                     AGQRAEFVWCDVSQEQSWVWLHNRVNEVFGPLDVLCSNASRQAPIPADELSRRQWDDGL
                     AINLTPLFLGVHTFIDDLRSQAGNVVAISSVHAQFGLPGYPVYAAAKGGLTALVRQ"
     CDS_motif       21797..21874
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_O3I_RS14970_0001"
                     /evalue="1.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="O3I_RS14970"
                     /protein_end="35"
                     /protein_start="9"
                     /score="18.2"
                     /tool="antismash"
                     /translation="VVTGGASGIGAATASRLAAEGAAVVI"
ORIGIN
        1 ggtcgccgcg acgagcctgg tgccgatcgc cggtctggcc ctggtccttt cggtcgatcg
       61 cttcctttca ctcatcagag cgctgaccaa tgtgctcggc aatgcggtcg ccaccgtcgt
      121 catcgcccgg tgggaaccgg gcggcctcga tcgcgaattg gctgctcgca ccatcgggtg
      181 gtcgcgcccg aaaaacacgg taggagagaa gtaatgcccc gaatcgtcgc catccacgag
      241 ggtgtcgtgc cgatcagttc ttcgatgagc aacgcgttca tcgacttcag tgccatggat
      301 tgttccgtcg tcgcggtggt cagcgatgtg atccgggagg gtgaaccggt cgtcggatac
      361 ggattcaatt ccaacggccg ctacagtgcg ggtgaaatcc tgcgccgcag gatcattccc
      421 cggctgctgc aggccgaacc ggatgacctg cgcaccgccg acggacaggc gatcgacccg
      481 gccaaggcgt gggatgtgat gctgcgcaac gagaaaccgg gcggacacgg tgaacggtcg
      541 gtcgccgtcg gcgtagtcga catggcgctg ttcgatctcg ctgcgaaact ggccgggcta
      601 ccgctctatc aatggctcgt ccggcattac ggattcgggg ctccggacac ggacgtattc
      661 gtctatgccg caggcggata ctacgcgccg ggcaagggcc tgacgcagct gcaagacgag
      721 atgcgcggct tcctggacca gggctacgac gtggtgaaga tgaagatcgg cggtgcgagc
      781 ctggccgacg acgtcaaacg ggtcgaggcg gtgctcgcgg tgctcgacgg cgacgggtcg
      841 cggctcgccg tcgacgccaa cggccgtttc gatctcgaca ccgcgctggc gtacggtcgt
      901 gccctcgcgc cctacggtct gttctggtac gaggagccgg gtgatccgct cgacttcgat
      961 ttgcacgcaa ggctttccgg gcagtacccg gggccgctgg cgaccggtga gaacctcttc
     1021 tcactcgcgg acgcccgcaa cctcatccgg tacgcgggga tgcgacccga tcgggactac
     1081 ctccagttcg acccggtgct cggctacggt ctggtcgaat acctgcgcat ccaggacatg
     1141 ctccgcgcgc acggctggtc gccccggcgc tgcattcccc atggcgggca ccagttctcg
     1201 ctgcacatcg ccgctgccct cgggctcggc ggcaacgagt cctatcccgg tgagttccag
     1261 cccaccggcg gcttcgccga tgccgccgtg atcgaacaca gccggatccg gctcaccgac
     1321 accccgggta tcggcttcga ggacaaggcc gagctgtatc gcgtcttccg cgcgctacat
     1381 cgctagatcc tggtggcgag gaactcgcgc accagcggta ccgcttcggc ggggtgctcc
     1441 gctcgcatcg tctcgccgat cgattcgaac tgccacaccc cgtcgctgcg gtacaccttg
     1501 cacatcacca agcccgtgtg cgagccgccg gcgctcaggt cgaatcgggc gagttcgatg
     1561 ccggacacgc tgtcgatcag gcggcagaac gcattctcga tctgctcgaa ggtctggccc
     1621 gtgtagcagg tcacgatgaa gaccgcggcg gtgatctcgg gcgacagcct ggtcaggtcg
     1681 acggtgatga tctcgttgtc gcccttgcct tcaccggtcg tgctgtcgcc gaggtggcgc
     1741 accgcgccgt cgcgcgagct caactgttcg tggtagacga cgtcggcgat ctgatcgccg
     1801 gcgaagagca gtgcggacgc gttgaggtcg atatccttgc cgggagcgcc gaaccagcgg
     1861 cccgggcgga ccggatccca gccgagcgcc atcgtcacgt aatcgagggc ggcgccgttt
     1921 tcgtcgcgaa gtgtagtgaa catcggtgtc tcccagcgtc gatcggcccg ccccgcgtgc
     1981 gcgggccggg tttgccgacc agacttcccg gcgcacctac ccgtaaagat gccgtaaata
     2041 tgcccgtaaa gcaaatgagt taggtgatat aagcggctga tcaccgacga tgagcgaggg
     2101 ggcatcgatg tctcgattgg acagcatcct gtggcccgcg ggcagccagg cggctccgac
     2161 cgtcgacgcg cagaccgtgc gggacctgaa tctcgaggac atcttcacca tcgtgacccg
     2221 cggggatccg accttggcgc gccatgtgcg cgcgccggtg gccgatctgg acactgtgac
     2281 gttccggcag gagatatttc gcgatctcgg tcgcgcggaa ctgcgggaac tcttcgaaga
     2341 attcgcgatg cggttgcgca tcgtgcacgc gttcgcgacc gcgtcggccg aacagcatca
     2401 tcgcaccacc ggacaccggc tgtatctcga cgcggtggtc ggttacggca gcgctctgcg
     2461 ggcgctgagc gcggcgcttt cgaccgtgcc gggcacctcg cggggattgc ggagttggca
     2521 gagctacctc gaaacatact tggccacaaa tcaattcgag gagcttatgg ccgtcgcgac
     2581 gcgtgtccag gctgggctcg acgccgtccg ctacaccctc tccatcgacg gcaggcaggt
     2641 ggtggtggcg cgggacgaca acgcgcagga ctacagcgcc accgtcgagc aggccttcgc
     2701 accgcttgtg cgtggattcc gccccgagcc ggcgccgccg gaaatcctct ccaccacagt
     2761 gcattacatg gaagagcaga tcgccgaccg ggtcgccgaa ctgttcccgg ccgaattcgc
     2821 cgagctggcg cggttctgcg ccgcgcaccc ccatttcctg gccccctccg tcgaatcgtt
     2881 ctatcaggaa ctgcgcttct atctctcctt cctcgaattc gtggatcatc tgaccggcga
     2941 ggggttcacg ttcagctgtc cgcggttgac cgagcggttc gaggaaatcg cggtgaccgg
     3001 cggatacgat ctcgcgttgg cggtgcggct gcgtggttcc ggacaatccg tggtacccaa
     3061 tgatttccgg ctcggcggca gcgagcgggt gctggtggtc accggaccga atcagggcgg
     3121 caagagcacc ttcgcccgca tgttcggtca actcgcctat ctggcggcgc tcgggtgtcc
     3181 ggtgcccgcg gcgagtgcca cgctgctgct cgcagaccgc ctgtccaccc atttcgagcg
     3241 cgccgagagc gtcgagcact cggcgggcaa gctgcacgac gaactcaccg aggtgcacgg
     3301 cgcgatccac gcctgcaccg ctcgctcgct gatcatcatg aacgagacgt tcagctcgac
     3361 caccacggcc gacgcgctgc agatcggcgg tgcggtgctg cgccgcatca tcgagcgggg
     3421 tgcggtcgcg gtgtacgtca cgttcctcga cgagctggca agcctgcatc cggccgtcgt
     3481 cagtatggtg gccggcgtcg gtgacgatcc gagcacgcgc acgttccgga tcgtgcgcag
     3541 acccgcggac ggcaaggcgc atgcggccgc gatcgcggat ctgttcggac tcggttacac
     3601 cgcgatagcg gagcggatcg cgcgatgaga gtcggtctgc tggaaccgga ttccgcccgg
     3661 gcgcagacgg tgcggcacgg cgcgacggtg gtgcgggatc tcgagctcgg cgtcgtgttc
     3721 gacgcgatgg cggccggcga tccgttcctg cgcgacagcg tcgagtcgat catggtgcac
     3781 gcgtcgaccg atccggcgac gatcaggtat cgccaggaag tgctcgccga ttgcctcgcc
     3841 gacccggccg cggtccgccg cctgtacgcg ctggtgggcg cgagcgaaag cgtgcgtcgc
     3901 tggacgatcg gtcgtggcgg tgcgccgcga gccaagctga atctctcgct ggaaccgctc
     3961 gccgaactga tcggtcacct ccggcaggtg cgtgccgcgt gcgcggctct cggcctgcgg
     4021 tcggcgggtt tcgcgcgact gtcggcgctg gtcacctcgt cgttccggga cgaagtgctc
     4081 gatgcggtcg aatcgcacgt cgacgcactg catttcgagc acggcgtagc gctgggcgcc
     4141 gggctcggta cggggaacaa gccggtcggc gtcgtgctgc acgagccacc gcgaccggcg
     4201 cggcgtggcc tgttcggcgg cgatcggcgc gcgcggcacg gcttcaccct ccccggccag
     4261 gacgagaagg gggcggagta ccttgccggg ctgatcggcc gcggcctgtc tccggtggcc
     4321 gaaatcgttt cgcacgccac ggatctgatc accgatttct tcctgtcgct gcgcaccgag
     4381 ctggcgttct atctcggctg cgtgaacctg cacgagcggt tgaccgcctc ggggtatccg
     4441 ctgtgctttc ccgagccgct gccggtcggc cgggccgagc tgcggtgccg ggaattacgc
     4501 gatcccaccc tggtcttgtc gtcgggcaag ccggtcggcg cgaacacggt cgacggatcg
     4561 ggccgttcgc tgatcctcgt cacgggcgcg aacagcggtg gcaaatcgac ctttctgcgc
     4621 agcgtcggcc tagctcaggt gttgctgcaa gccggaatgt tcgtgctcgc ggacagtttc
     4681 gcggcggatg tgcggaccgg cgtcttcacc catttccgga cccaggacga cgccaccatg
     4741 acctatggga ggtggaaaga ggagctggcg cggatccggg acatcaccga tgcgatccgg
     4801 cccgccgccc tgctgctgtg caacgagccc ttcgcttcga ccaatgaacg ggaaggaacc
     4861 cagatcggcg ggccgatact gcgggcgctg cacgatgccg gcgtgaaaat cgcttgtgtg
     4921 acccatcttt acgatctggc ccgggagttc tatgacgggc agaccggggc cgagctgttt
     4981 ctgcgggccg agcggttgcc ggacggcaca cgcaccttcc gtgtggtcga aggcgagccg
     5041 gtagccacga gtcacggggg tgacgtgttc cgccgcgtct tcggcgatga tcggatgtcg
     5101 gtgtagcgca ctatggacgg gaggcgtcac ggattccccg cgacgcggat ggaggcgggt
     5161 ctcatgtcgg acaccaacaa gcgcaatctc ctctacttcg aaagtccgtc catgcgtggg
     5221 ctgtacgagg cgatcgacga gtggcaggag tccgccgagc ggcggctgct ctcgctcagc
     5281 atccagcgcg acggcgacaa tttctgctgc ctcgcgctga ccaacccgtc cgaggtcgtg
     5341 atcaccagtc ccgacgggca caatcacgcc aacgtcagtc ggttcgggac gctggccgtc
     5401 gacgcggttt agccgccgcc ccttcggttc cggtgaacgc gcccgcgcgc gcggccagcg
     5461 cggcggtcgc cgcggcgtgc gcgggcaggc ccggatcggg tggagtacgt agcaatatca
     5521 gctggtggta gagcggcgcg gtcgcggcga tcagcaaggc gcgggcgtcg atgccgggct
     5581 cgagttcgcc gcgccggacc gcgcgttcga cgacgatctc cgattgcgta taccggccct
     5641 cccatagtcg ctgcagggcg tcggcggccg ccgcggagcg gaacgagacc gcgatcagcg
     5701 cctccgcgat ggaggattcc tcggtcaacg agtcctggat ctcctggttg agtgcggtca
     5761 gatcgccgtg cagggtgccg gtgtcgcgcg ggtgccagtc gagatcgctc gccgcggcga
     5821 agacgtcggt gatcagtccg gccacatcgc gccagcggcg atacaccgtg gtgcgatgca
     5881 cgcccgcgcg tgcggcgacg gtgtcgaccg tgagcgcgtc gtagccgtgc tcggtcagtt
     5941 ccgcgcgtac cgcgtcgaga acctgatccc ggatgcgcgc ggtgcggccg cccgggcgtg
     6001 accgcgggga cgaatcagct ggtgaagggg gcaatgtcga cgacccggtt gctctggagg
     6061 gatgggctgt ggcaccatat taacgcaaca ttcgtcgcac tagtgaggta ggccgatggt
     6121 cattcgaagt gttcccccgg tcctgcggtg ctcggtcacc gcgtcctcga atgcttcgga
     6181 gtgtgcccat gccaacccag atcaccgcgc acgcggtcac caagtccttc gacggccgtc
     6241 gcgtactcga tgaggtgacc tgtgtgctcg ccgcgggcga gcgcaccggg atcatcggcg
     6301 agaacggctc cggcaagacc accctgctgc ggctgctcgc cggtcgggaa caacccgacg
     6361 agggcgagat cgtcgtgcac gccgagggcg gcatcggcta cctcgcgcag gacgagtacc
     6421 tgccgccaca gctgaccgtg caggaggtcg tcgaccgcgc cctcggtgaa ctccgtgcga
     6481 tcgagcaccg gatgcgccgc ctcgagtccg cgatgggctc cggcgacgaa tcgggtctgg
     6541 ccgaatacgg cgagctgacc acggttttcg aactacgcgg cggctacgac gcggatgcgc
     6601 gggtggaacg ggcgctgcac ggcctcggtc tcggactggt cgggcgcgag cgcaccgtcg
     6661 gcgaactgtc cggcggcgaa caggtccggt tgcgcctggc cgcggtgctg gccgccggat
     6721 cggaagttct gctgctggac gagccgacca accacctcga cgacgacgcc ctgacctggc
     6781 tggaagacca tctgcgcacc cggcgcggga ccaccgtgac ggtgtcgcac gaccggacct
     6841 ttctggaacg ggtcgcgacc accctgctcg aggtcgatgc ggatcggcgg cgcgtcatcc
     6901 gctacggcaa cggctacgcg ggctacctgg ccgagaaagc ggcggcgggg gagcgctgga
     6961 tgcaggccca cacgcagtgg caggccgatg tcgatcggct gcgcgagttc gccgccacca
     7021 ccgcgcgtcg cgtcgcaccc ggccgggcga tgaaggacaa caacaagatg agctacgacc
     7081 gagccggcgg ccgggtccag caatcagtgg ccggccgggt ccgcaacgcc gaggaacggt
     7141 tgcgccggcg cctcgccgaa ccggtaccgg ccccgccgga accgctgcgt ttccgggctg
     7201 cgctgcacgc gggacgaacg caaggcgcgg tgctagaggc cacggacgtc gcggtcgagg
     7261 gcaggctgga acggatcggt gtcacggtgg cggcggggga gcgcctgctg atcaccgggc
     7321 cgaacggggc gggcaagtcc acgttgctgc gggtgctggc cggcgcgctc gcaccggatc
     7381 gcggcacggt gctccggcgc ggccgggtcg gctacctcgc gcaggaaccg ccgcccgccg
     7441 cgcccggcga aactctgctc gccgccttcg gccggggccg cggcggtggg gccgatcagc
     7501 acgccgaggt attgatgtcg ctcggtctgt tcgaccgcac ccggctctcg gcacgggtgg
     7561 cggagctgtc caccgggcag cggcagcgac tcgcgttggc gcgcttggtc accgagcccg
     7621 ccgacgcgct gctgctcgac gagcccacca accatctgtc acccggcctg gtcgaggagt
     7681 tggagaaagc tttggccgac tatcgtggcg cgctcgtgat cgtcagccac gatcggcggc
     7741 tgcgcgcgcg ctggcggggc gcgcacctcg ccctgcggac ctgcgtctcc gtctgatcga
     7801 ccgattaccc acgcaccgaa ggagtttcac cgtgcccgac agtcctgtgc ggcagcccgc
     7861 cgacccggcc gtgctgcatc ccatgcccgg ccagccgcgc gtggtgcaac tgcggcccct
     7921 gctcacctcg cccctgatcg aggtcgggga ctattcctat tacgacgacc cggacgacgc
     7981 gaccgcgttc gaaacccgca acgtgctgta ccactacggg ccggagaagc tgatcatcgg
     8041 gaagttctgc gcgctgggca ccggcacgcg gttcatcatg aacggcgcca accaccggat
     8101 ggacggcccg tctacgtttc cctttcccac catgggcggt tcctgggcgg agcacttcga
     8161 cctgctcacc gatctgccga accgcggcga caccatcgtc ggcaacgacg tgtggttcgg
     8221 caacggcgtc accgtgatgc ccggtgcgcg gatcgggcac ggcgcgatca tcagcaccgg
     8281 ctccgtggtg accggcgcgg tgcccgatta cggcatcgtc ggcggtaatc cggcccggct
     8341 catccgaacc cgctacagcg acaacgacat cgcgcgtctg ctcgccgtcg cgtggtggga
     8401 ctggcccacc gcacacctca ccgcccacat ccggaccatc atgtccggca ccatcgacga
     8461 tctggaggcc gccgccgcat ccttggactg acgagaaaag ccttatgcga caggagcttt
     8521 gcttgcggta ggaaccgcca aggggaggaa ggccgggcgg cggtccaggc gcgcccggtc
     8581 gacgggcgcg gcgaaatggt ggtccaggcg gcgggccgct tcggcccagt cgcgcatggt
     8641 gcggacgggg gcgagggtct ggacgacgaa agggtccgac cagcgcgcta gtgcgcgctc
     8701 ccacaagacc atcggaggtt cgtcgaggac gctgccgacg gtgccctcgt agatcggcat
     8761 cgcgtgcacc tcaccgtcgg gccggacatg catgatgggc aggacgctgc cctcggcgac
     8821 atggtccggg tggatcatgt cgtgccagtg gtcgtcgatc cggatatcca gtcccgcggg
     8881 cgcgaggtcg cgcaggtgcg cgagatactc agggctgagc aggcgttggg attcggcgtc
     8941 gtccagcagt tcgtgatcga cgaacccagg gcggttggcg agcccggcgg gcatggtcac
     9001 ggtgaacacc agatgccgca gttcgggaaa acggggcgcg atggtcgtgc agaactcctc
     9061 gacctgatgc agattgctgc gcatgatcga cacctcgatg ccgagcgtgc cggggtcctg
     9121 cccttcggct ttcatccggc gtgcggtgcc gtcgaggagt tgcaccgcgg ccaggccccg
     9181 ctcgaaggcg cgcgcccggc cccggatgcg gtcgtgcaca tcggcggtgg cgccgtccat
     9241 gctgaccgcg acagtgctga agtgccgcaa cgactcttcg gccttgtgcg cgtccacggg
     9301 taggccgctc gtgtagagga tgacggagat gcccgcctgt gtgaaacgct cggcgatctc
     9361 gaaaacgccg tccaccagca acggttcgcc gccggcgatc gccacctcct gcggctgcag
     9421 ggaaaggaac gcgtccgcca tgcggaagag ttggtcgcgc gccggatgca aggtcggccg
     9481 ccggcccgat tcggaatagc agtgcacaca ccgtaacggg cacgcgtagg tgatatccca
     9541 gattattcct accggacctt ggctgacgtc cacgggaaac cccttccccc agaataattc
     9601 ggttgagtgc cgttcacggt aatgcggcgc cggagtagga gcgactcgct ggttcggtga
     9661 gcggaccggc gcatggcaat tcggctaccg ctcgccgaac aatgatggcg cgtccggtaa
     9721 ttcaaccggt tgctgtcggg cctgcatcga cccgattcga gaaaggaagc gacgatggag
     9781 cgagaaatcg agcagctgag cacggatgtg gctgcgctgc agacgctgcc ggaacgtgat
     9841 cacggcgccg gcgcggtcat ctggccggac cccacccggg gctcggcctg ccgcggcgat
     9901 cagtgatcca ggggctttcc gtgtgacgtc gcggagggga gtgctgtccc ctccgcacgc
     9961 acagtgaaag atgctaccgc gcacaggaat cggggacggg atggtgaatc cggtagccga
    10021 ggcgactctc gttgagctgg cgcagcgcca cctcgccggg cgctccgatc ggcgaatctg
    10081 gaccgacggc gtctggtgcc atctgagccc ggtgaattat cgctggccgc ggcaggggtg
    10141 gaagctgcat atcgcggcca cggtcgggtc ggccgccacc gtactcgacc gcacgctcga
    10201 cattgtgctg cgcaccgaat gctcgggtaa attcgccgcc tcgctcgagc aggtgcgccg
    10261 attgaattcg gccgactatc cgcgtggtgg cgcagggaaa ttcatcaccg tctatccccg
    10321 cgacgatgca cagctacgcg tcctggcggc gctgctgcac gaagccaccg ccgggctcgc
    10381 cggaccggcg attctgtccg accggcccta tgcggccggc agtctggtgc attaccgcta
    10441 cggggagttc ctcggcgagg acgtcatcgg tggcagcggc gactatctgc cgatgctgac
    10501 cgcgccggac ggcagccggg tcgaggaccg gcgcgacgcg tggttcgcgc cgccggtctg
    10561 ggcggacgat cccttcggcc ggccccgatc gacggaaaag gcgacgagcg gtgtgctgct
    10621 ggcgaatcgg ttcgaggtgc gccgggcgat cgtgcacgcc aacaagggcg gcgtcttcga
    10681 ggcgaccgat cggctcaccg gcgcggaggt ggtggtcaaa caggcgcggg cgggtgtggg
    10741 cgacggcccg cacggctgga atgtgcagga cgcgctgcgc aacgaagccg agatgctgga
    10801 cctgctgagc ccgttggcgc cgcgccgact cgccctgttc gagcagcagc acgacctctt
    10861 cctggttcag gagatgatcg cgggcaccac ctttctcgag tggcgcggcc gtcggcacgg
    10921 tgcactggac tggcgcgcga cggcactgcg gctcaccgag ctgctggccg cggtgcacgc
    10981 ccgaggcgtg gtcctgcagg acttctcggc ctcgaacgtg atggtgcgtc cggacgattc
    11041 gctggtgctg gtggacctgg agttcgccgg ccggtccggc gctatccgga tgaccggctg
    11101 gactccggat tacgccgcgc cggagcagat ttcaggtgct gcggcggatt tcgcggcgga
    11161 tcgtcatgcg ctgggcgcgc tgctgttcct gctgtgcctg ggcgccaagc cgagcttcgc
    11221 gcccgatgat cgtccggcga ggagcaaggc cgcacgcatc gcgcgactac tggagctggc
    11281 cgccgagacc gaccgcgaga tcgccacggc gcgtccgctg ttgctcggct tgctcgcgga
    11341 cgacccggct gagcgctggt cgctcgaccg cgttcacggc tttctcaccg gcgaccacca
    11401 ggacccgccg cgacggcgtg cccggcaccg gacgaccgat atcgatcgcc tgctggacga
    11461 cggcgtcggc tatctcctga acacgatgac gcccgccggg gagcgccttt ggccggtcag
    11521 cgacggcggc aaacgcagcg atccgtgcaa cgtctaccac ggtgcggccg gcgtcctcgc
    11581 caccttgacc cgcgtcgccg aggtccgccg ggacgcgcga gtgctcgccg cgttgccgat
    11641 cgccgccgac tggatcatcg accggacgac cgcgcgaaac ccggtgcccg gcctttatat
    11701 cggccgctcc gggaccgctg tcgcgctgtg cgccgcaggc cgggtcctgg attcggagcg
    11761 tctggtccga gtgggtacgc agctgttcgg cgaggttccg cgcgactggc cgaacaacga
    11821 tgtcacccac ggactcgccg gtgcgggcta cgcggcactg ctgctctggt cggcgaccgg
    11881 ccgaaccgaa ttccgcgacc gcgcagccga atacgcggcg gtcctgaccg agcgcgccga
    11941 gcgccgggac ggtgtgctgg tctggccggt cccgcacgac tacgactccc gctacgccgg
    12001 ctccgtcgac tacggattcg cgcacggcac cgctggaatc ggtgcgttcc tgctcgccgc
    12061 gggcagtcgt ctggacgagc cgcggtggct ggagcttgcc gccgaagcgg ccgaaagttt
    12121 gtgtggcgca gccgtgccca cggatgtggg cgcgctgtgg ccgatcgggc cccgggatac
    12181 gacgcgcctg ctcgatcact ggtgcagcgg ttcggcgggc atcggcacgt tcctgctgca
    12241 gtactggcag gcgagcggcg accggcaggc gcggtcctgg gccgaacgcg ccgccgaggc
    12301 agtgggggcg cgccgctggc gggccggggc cacgctgtgc cacggcctcg cgggcagcgg
    12361 ggaactgctg ctcgatctgt gcgcggcgac gggagacgag cgcgcgcgag tgcgggccga
    12421 ggggatcgcc gccgcgctcg cggtccgggc cggtaggcat cggggacatc tgctggccgc
    12481 ggacgagacg ggcagcggct atggcgccga ctacgccgtc ggcgtggcag gctgggtcga
    12541 tttcctgctg cggctaaagc acggcaatcc cagggcgtgg ctggtcggac cacgctgacc
    12601 acaccgggca tcgccgagta cttcgcgtgg cgaaacgaaa tgcggaacaa tcgctgtgca
    12661 cagcgaaggg ttcgccatga acgtagccga ttctgctcga cccgagacgc ccgtccgacg
    12721 cctggatcgg cgccgcgtcc tcggcatgat ggccgccgcg cccgttgcgg tgccgttgct
    12781 ccgtgcggcc gcggcgacgg cggcgccccg gtcgcggccg aacatcctcg tgctcatgac
    12841 cgatcaggag cgggcggatg tggtgctgcc ggcgggattc gagctgccga cgcgggcccg
    12901 gctggcggcg aacggggtgc gcttcgccat gcatcacacg cccaccgcac cgtgctcgcc
    12961 cgcgcgctcc accctcttca ccggactgca cgccccggtg agcggcatgc tcgacaacgt
    13021 gcgcggcaac gatctgatgg gcacggtgct gggcgcgatc cagacctgga gtcctgacct
    13081 cgactccgcg gtcccgacac tcggcaccgt gttgcgggcc gccggctacc acaccacata
    13141 tatcggcaaa tggcatctgt ccgacgaggt ggccgccgat ccggcggcgt tgtcggggta
    13201 cgggttcgac gaggcccacg acatcctggc cgcgggcggc ccgaacgagg gcacccggca
    13261 ggacccgggc gtggtcggcc acgccgtcga ctggctgcaa cgccacggcg gagatcccga
    13321 cccgtggttg tgtgtggtga gcatggtgaa tccgcacgac atgatgttct gcccgcgcct
    13381 ctaccgattc gaggacgtgc cggagtacgg cgccgacgtg ccgccgaatt tcgaatccga
    13441 cctgaccacc aagccgcggg tgcagagccg ctggcgcacc atcaacggca tcgtcggcgg
    13501 gccaatgccg accgaactcg attcgcccga tgctcgtcgg cagtggcagc gctggggcaa
    13561 ctggtatctc gaattgctgc gccgcacaga cgaattgagc gggcaggtgc tggccgccgt
    13621 cgagcgcagc ggcgctgcgg acaacaccgt ggtggtgcag gtcgccgacc acggcgaact
    13681 cggtggtgcc cacggcctgc ggcagaaggg ggcgatgatc tatcgggaga acaaccgggt
    13741 accgctggtc atcgccgatc cccgtgcgcc ggccgggcac ggccggaccg cgaatgcgtt
    13801 gacctcccat atcgatctgg tgccgacgct ggcggcgctg gccgggatcg acggtgccgc
    13861 agcgggttcg gggccgggcc ggaatctggt gccggtgctc gccgatccgg cgcgcacggt
    13921 ccgggacgcg atcctgctca cctcggacgc gaaatccagt gggggacagc tgccgggcag
    13981 ccggtactgt ctgcgcggcg cgatcaccgc ccgctacagc ttcggcagat actccactcc
    14041 ggagcagctc ggcgggccgc gcggcgagtt cgagtacgaa ctctacgatc gccaggtcga
    14101 cccgctggag ctgcacaatc tcgcgcacgg cggcggcgcg gccggactgg tcgaggacct
    14161 gaacgatctg gtcgattcgc tgctcgcccg ggaactgcgc cggcccgaca ccgaaacccg
    14221 ttgagccgca attattgctg cggcgcagcg gtctcggacc gcgtcaggtc gccgaggtgc
    14281 gcagcgcgcg gcgggcggcg atggagccga acgtttcccg gtcggcgagg aatccgtcga
    14341 gggcgaaggt ggcggcgccg agactggccg gattgtgcgg cagcgccgag agttgcagtg
    14401 tcaccgcgtc gaaggggtcg gtcatcgcat gatgggcggc cacccgccgg gtcacctcga
    14461 gcagcggcgg gccgagatga tcggcgacca ggtcgccgaa gaccatggtg cgcgggttga
    14521 acaggttgac cagattggcc acggcgacac cgagatagtg ccctgtccgg tcgatcaccg
    14581 ccagtgcgac cgggtcctcg cgcccggccg ccgcggcgat cgccgcgatg gtggcggcgt
    14641 cgtcggacgc gagcatcggg ctggccgggt cgagttcgcg cagggtgcgc acgatcccgg
    14701 gcgcgccgac gtacgcctcc acgcaacctg ttcgcccgca acggcattcg cgcccgtcca
    14761 gcacgagatt ggtgtggccc cactcgcccg cgctgttgct gaccccgcga tagagcatcc
    14821 cgtcgacgac cacgccgatg ccgacgcccg cgcgcagcgt caccacgatc agatcgtcca
    14881 catcacgccc cgcgccgaac cagagatgcg ccgcggtact ggctttgagc ggattgtcga
    14941 gatagagcgg atgcgggagc tggtcgtcga gcagctcctt gagcggcaca tcgtgccaat
    15001 gccagtacgg cgagaagacc gagatcccgc cttcgggctc gaccaggccg ggcacgctca
    15061 acccggcgcc gagcaccttg tcggcgtcgc ctgcggtgag ttcgcggatg ccgcgaatga
    15121 tgagcgcggc gacatcgtgc ggctcggtgg cggccgggtc gacggggatc tccaccgcgc
    15181 gcaatgccgt catggccagg tcgaaaaggt cgaagtggat cgctgtttcg gcgatgtcga
    15241 cgccgaccag caggccgcgg tcggggttga tcgcgagccg ggcccggggc ctgccgacgc
    15301 ccggcgcgtc gtgaccgagc tccacgagca cgccgacgtc gagcagttcg gcgatcatgt
    15361 tgccgaccgt ggcgaacgag agcccggtcg cgcgggcgat gtcctgcctg ctgatatggc
    15421 cgtcggcggc gtacaccgcc tgtagtacgc cgaacctgtt gcggcgccgg atgtcgcgcg
    15481 cggtcagctg atacacggtc ggatctcctc ctgcgctggt ggcgtcaaca taccgaacga
    15541 cttcgaccaa cagtatttac aacagttagt ggaagtctta ctgtaacccg catcactatg
    15601 cgacgcgagt atgcgtcaga tcactaggag tgcccatgtc ctggacccat cgacgacgtt
    15661 ggaccagtgc cgtgctgtgc ggaatctcgc tcgccctggc cgctaccgcc tgttcgtcgg
    15721 gcaaggaaag cgcctcgccc gccgcgggcc cgcagcagca aacgggcgcg atcagcctgg
    15781 tctacgccca gaagcagggc gatcaggagt acttcatcgg cgaagccgag ggggccaagg
    15841 ccaaggccaa ggaactcggc atcgacctca aggtggtcaa cctgggcaac gacgcgaaca
    15901 aggcggtcac cgaggtcaac aacgcgatca accagaaggc gagcggcgtg atcgtggtgg
    15961 tccccgaccc gtcggtcggc ccgcaggtcg cccagttgac caagaccggc ggcgtcgcgc
    16021 tgctgacctc cgacgatcag gtctgcacca ccgggcccga tccgtcgaaa tgcgccaagg
    16081 atcaactggt tccccgggtc ggcttcagcg ggacgcagat ggggaccgag gttggccgcc
    16141 gagccgggca ggacttcaag aaggcgggct ggaagccgga agagaccgcg atcgtcgagg
    16201 cttggaagca ggacgtgacg gtgtgcaccg accgtgtcga ggcgaacaag aaggcgttcc
    16261 gcgaggccgc gggcgtcgac gtccgagtga tcgaggtcgg taccgacaac accccgtcgg
    16321 acgcgcagaa caagatctcc gcgaccgtcg cgggcaaccg gtcggtcaag aactggatcg
    16381 tcatgggctg caacgacgag aacgtcagcg gcggcgtcgc cgccatccag aacgccgggt
    16441 acgccgcgga caacgtgctc ggtgtcgggc tcggcgccta tctggcctgc aaggagtggc
    16501 gtggcggcaa gccgaccgga ttcaaggcgg ccctgttcat caacggcaag gacgtcggtg
    16561 cgctggcggt gcagaccatg cacgactact tgaagaacgg caaggccatg ccggccgagg
    16621 ccttcgcccc gaccaccatg gtcgacgcga gcaactggca gcaggcgggc gtcacatgca
    16681 gctgagcggc ctgcgcgcca ccggcctcag caagagcttc gccggggtgc ccgccctgcg
    16741 cgaggtgagc ctggacttcc cggccggcgc ggtgaccgcg ctgatggggg agaacggtgc
    16801 gggcaaatcg accctgatcc ggattctcgg cggcgatcac cgcccggaca gcggtcggct
    16861 cgagctcgac ggcgtgctac tcgatcaggc caccccggcc gccgcgcggg cggccgggat
    16921 ccgggtgatc ggccaggaac ccgagatcgt gccgcatgtg tcggtcgccg agaacgtcta
    16981 cctcggcgcg ctgccgcgcc gggcgggccg gctgctcgac cgggcggcgc tgcacgagcg
    17041 gatgcgcacc gatctggccc ggctgggctt cgaccgggat ctggatccga gcacggtggg
    17101 ctcgaaactg actgcggcac agcggcaatt ggtcgagatc atgcgcgcgt tgaccaccga
    17161 cgccaaggtg atcgccttcg acgagcccac ctcgtcgctg tcggatcacg agaccgaatc
    17221 actgttcgcg ctgatcgggc ggctgcgcga gcgcgggctc gcggtgatct acgtgtccca
    17281 tcggatgcgg gagatcttcc gcctcgccga ccgggtcgcg gtactgcgcg acggtgcgct
    17341 ggtcggggtg cgcgcgaccg cggagaccac cgatcaagag atcgtccgca tgatggtcgg
    17401 ccgggatctg tccacgctgt tcgcccgcgg tccggccgcg ccgggccggg tcgtgctcga
    17461 cgtggacgcg gtcaccaccg acgacgtgtc cgacgtgagc ctgcaggtgc gggccgggga
    17521 agtggtggcg ctggccgggc tggtcggcgc gggccgctcc gagctggccg gtgcgctggc
    17581 cggggacctg ccgatccgct ccggcacggt gcggatcgac ggcaagccgg tgcggctgcg
    17641 gcaaccgcgc gacgcggtgc gagccggggt cggctacgcg ccggaggagc gcaaggcgca
    17701 ggcgctgctg ctgcatcgcg gtgtgcgcga caacatttcg ctcgcgatgc tggatcggtt
    17761 gcgccggctg cggttcgtca aggccggtgc cgagcgccgg ctcgcgcagc agtacgtggc
    17821 gtcgttgcgg gtgcgcacgc cctcgatcga gcaggaggtg cgcaaactct cgggcggcaa
    17881 ccagcagaag gtggtgctgg cccggtggct cgcgcgtaaa cccaaggtgc tgatcctgga
    17941 cgagccgacc cgcggcgtcg atgtcggcgc caaggccgag atctaccgca tcatcgagga
    18001 attggcggag gcgggcgtcg ccgtgctggt gatctcctcg gaactacccg aagtgctcgg
    18061 cctcgccgac cggatcgtcg tcatgcagca ggggcgcgtc accggcgaac tggaccgcgg
    18121 cgcggccagt gaagaggcgg tgctggcgct ggccatggcc gcggacctga catctctagg
    18181 aaaccaatga cggagcaaca actcacagcg gtgccggtgg caccggccaa cccccaagcg
    18241 cccgagcgca atcgctatgc cgccgcgttc acgccgcggc gcatactgca cgcgatcggt
    18301 ccgggaaacc tcagcctgat cggcgcgctc gcggtcatcg tcgcgatctt cggctccctc
    18361 aacgacggct atctcgaccc cgcgaatctc gccggaatcg gtgacgcggt aacggttttc
    18421 ggcctgctcg cggtggtgca gacggtggtg atcatctgcg gcgccctgga catctcggtg
    18481 ggctcgcagg ccggggtcgc ctcggtactc agcgcgatgg cgttcaccgc gacctcgggc
    18541 aacgccttcc tcggcatcct ggccgcgatc ggcatcggac tggtgctcgg gctggtgaac
    18601 ggcctgatca tcgtgtacgg ccgggtgaat cccgtgatcg cgaccctggc caccttggcc
    18661 gcgtacaagg gtctggccca attgatctcg ggcggcaagg cgcagggttt cgtgctcgac
    18721 aacgacgtct tcatcttcct ggcccgcggc aagatcatcg ggttgccggt gccggtgatc
    18781 atcctcgcga tcgtcgcggt ggcggtgcac gtgctgctga agtacaccga tatcggccgc
    18841 aacatctacg cgatcggcgg caacgacacc gccgcaaggc tttccggcat caatatcaac
    18901 aagtacctga tcgcggtgtt cgtgctcgcc ggggtggtgg ccgcgatcgc gggcatcatc
    18961 ctgaccgcgc gcaccggatc gggacagccg gtgtcgggca gcgaagggct cgaactcaag
    19021 gcgatcaccg cggcggcgct gggcggctgc gcgctcaagg gtggaaaggg cacggtcggc
    19081 ggcacgctgc tcgccgtggt cctgctcggc gcgctggaca acggcctgaa cgtggtgggc
    19141 gtcaacacct tctggcagaa cgtcgcgcag ggctccctgc tcgtcgccgc cgtggtgatc
    19201 cagcagcggc gcagcggtga gcgcgccgtc ggattgccga cctagcgccc gtcgccgaat
    19261 caacctccca ggagtggatc atgatcagtt tgcgcgcgca gccgtgcacc ccggcgcccg
    19321 gacacctgtg cgaaagtccg gtgtgggaca gccggactca ggaactgctg tgggtggaca
    19381 tccgaggcgg gcacatccat cgcgcgaccc tcgaccgggc gacgctcgat ctcacgcacc
    19441 ggtcgaccgt gagtttggcg ccgccggtga gcgcggtggt gccgtgcctg tccggtggac
    19501 tgctcgcgac cgcgaaggac accatctatc ggatcgacca cggcgaggtc acccgggtcg
    19561 cgggaattcc gttgccggac gacggaaacc ggcggcggtt caacgacgcc aaggtcgatc
    19621 cgcgcgggcg gctgctcgcg ggcacgatgt cggaggacgg tgtcgcacgc agcgccgcgc
    19681 tgtaccggct cgatcccgac ggcgcgatga gcatcctgcg cgagggcgtc acgatctcca
    19741 acggcctcgg ctggagtccc gacggggcga ccttctacta cgccgacagc cctacccagc
    19801 gggtggacgc cttcgactac gacctggata ccggaacctt caccggcaga aggaccttcg
    19861 ctagattcga ggacggtgat ccggacgggc tgaccgtcga tgccgcgggc tgggtctggg
    19921 tggcggtctg gggcgcggga caggtccgtg ccttcgaccc ggacggcgag ccgcgcgcgg
    19981 tcgtcgacgt cggcccctcg caggtctcca gctgtgtttt cgccggtccc gagctggacg
    20041 tgctggtgat caccaccgcc gcggaggggc ccgcggtgct cgagcccgac tccggacgtc
    20101 tgttcacctg cgtgccgggc gcggtcggcc tgcccggcgt accgtacgcc gacaccacgc
    20161 tggtgcgtaa ccatggctga ggatcccctg gagttggcga cgccggtcat cgcgatcctg
    20221 cgcgcaccga cggcgcagcg gttcgccgag gtcaccgccg tgctgcacga atcaggtatc
    20281 accgcggtgg aattcacgct caccagtgcc ggggcgttgg acgcgatacg cgcgtgtgcg
    20341 ggcttcgcgt atcgcatcgg cgcggggacg gtacgcaccg ccgcggacgc ggcacgggcg
    20401 gtcgacgccg gcgccgcgta cctgatcacc ccgatcgtga gcgaggaggt gatcgcggcg
    20461 ggactcgacc tgggtgtccc ggtgatctcg ggtgcgttca cccccaccga gatccatcgc
    20521 gcatggaccg cgggcagcac catggtcaag ctctttccgg ccgcgtcggg cggacccggc
    20581 tatctccggg ccgtccgggc gccgctgccg gagattccac tggtgcccac cggtggtgtg
    20641 ggactcggcg aggcacaggc gtatctggat gccggggcca cggcgctggg catcggctca
    20701 ccgctgatcg gcgacgcttg cgccggtggc gatctggacg ccctacggga acgcgtgtcc
    20761 gtgctgcgcg cggggttgtc gtgatgtgcg cggcagttcg ggagcggaat gtcatgcggg
    20821 gcactctggt aactctcggc gaggcggtag gggtggtggc cgcggtcgag ccggggccgc
    20881 tcgcacccgg cgcggcgctg cggatggact tcgcgggcgc ggaggcgacc gtggcgatcg
    20941 gcgtgagcag gcttgggcac cacagtgttt gggtgggcag cgtcggtgac gatgccgtgg
    21001 gcaccatggt gctggaccga ttgcgggccg aacgcgtcga cgtctccggg tgccggatcg
    21061 acccggagct gccgagcggt ctgatggtgc gggaacggcg caccgccgac cacatccggg
    21121 ccacctacta ccggcgtgga ctggccgggt cgagactgtc ggtcgcgcag gtcgacaccg
    21181 aacagatcgc ggccgcgggc gtgctgcatc tgaccgggat aaccccggcg ttgagcgcgt
    21241 gcgcgcgcga cgcggtgcat gccgcgctgg acgcggccgt cgaagcgggc gtgccggttt
    21301 cgctcgacat caactatcgc agtgcgctgt ggtccagggc ggatgccgcc gcagaactcg
    21361 cgaaactggt gtcgcactgc gacatcgtct tcgccgggct cgatgaggca gcgttgctgg
    21421 tgcccagcgc gagcgcgtcc gcgatggcgg aatctcttgc ggcactgggt ccgtcgcagg
    21481 tcgtactcaa gctcggcggc gacggcgcgc tggcgctgca ccgcgggcgg gtgatccggc
    21541 agcaggcgat cccggtgacc atggtcgatc cggtgggtgc gggtgacgcg ttcgtggccg
    21601 gctacctcgc gggcgtgctg gacggcacgt cggtgcggca caacctgcga ctggccgcca
    21661 cctgcggcgc gttcgcggtc tccgtacccg gcgactgggc gggattgccg tcacgccggg
    21721 agctggactt gctgaacggc accgacattc aacgatgaaa ggaaggcctg tgagtcgtct
    21781 ggcagaacgc gtcgcggtgg tcaccggggg cgcttcgggg atcggcgccg ccaccgcgtc
    21841 gcggttggcc gccgagggcg ccgccgtggt gatcgcggac atcgccgaac cggcgggcga
    21901 ggaggtggcg gcgaagatcc gcgccgcggg tcagcgcgcc gaattcgtct ggtgcgacgt
    21961 gtcgcaggag caatcgtggg tgtggttgca taaccgggtg aacgaggtgt tcgggccact
    22021 ggatgtactg tgcagcaacg catcccggca ggcccccatc cccgccgacg aattgtcccg
    22081 gcggcagtgg gacgacgggc tcgcgatcaa tctgacgccg ctgttcctcg gcgtacacac
    22141 cttcatcgac gatctgcgtt cgcaggccgg gaacgtggtc gcgatctcca gtgtgcacgc
    22201 gcaattcggg ttgcccgggt atccggtcta tgccgcggcg aaaggcggcc tgaccgcgtt
    22261 ggtccggcag ctcgccgtcg aatacggcgg tgcccgagtg cgattcaacg cgatcctgcc
    22321 cgggccggtc ctcaccccgg tgtgggacga cgtcgacgag gaaggccgca ggctgtccgc
    22381 ccgcgccacc gtcctggacc ggctcggtgc gcccgaagag gtcgccgccg cggtggcctt
    22441 cctcgcctcc gacgacgcct ccttcatcac cggcgcgaac ctggtcgtcg acggcggctg
    22501 gagcgtacga aaggaatccc ggtgaagatc accgcattga ccacctatct ggtcgcaccg
    22561 cgctggtgtt ttctgcgcat cgacaccgac gaaggcat
//
