LOCUS       NC_018681              25714 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Nocardia brasiliensis ATCC 700358, complete sequence.
ACCESSION   NC_018681
VERSION     NC_018681.1
KEYWORDS    RefSeq.
SOURCE      Nocardia brasiliensis ATCC 700358
  ORGANISM  Nocardia brasiliensis ATCC 700358
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Complete genome sequence of Nocardia brasiliensis HUJEG-1
  JOURNAL   J Bacteriol 194 (10), 2761-2762 (2012)
   PUBMED   22535940
REFERENCE   2  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-SEP-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
REFERENCE   3  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000250675.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 01:53:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,551
            CDSs (total)                      :: 8,489
            Genes (coding)                    :: 8,417
            CDSs (with protein)               :: 8,417
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 13 of 72
            Pseudo Genes (incomplete)         :: 63 of 72
            Pseudo Genes (internal stop)      :: 3 of 72
            Pseudo Genes (multiple problems)  :: 6 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:09:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3257922
            Orig. end                         :: 3283636
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003876.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25714
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="16"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25714
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25714
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15714](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15714
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            821..967
                     /locus_tag="O3I_RS43355"
                     /old_locus_tag="O3I_014565"
     CDS             821..967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007169078.1"
                     /locus_tag="O3I_RS43355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014565"
                     /product="hypothetical protein"
                     /protein_id="WP_014983729.1"
                     /transl_table=11
                     /translation="MKRNLNCPCGEAIVGVDEDDLVEKTQAHLAANHPGHEYSRDEILF
                     IAY"
     gene            1323..2273
                     /locus_tag="O3I_RS14755"
                     /old_locus_tag="O3I_014570"
     CDS             1323..2273
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS14755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_014570"
                     /product="hypothetical protein"
                     /protein_id="WP_014983730.1"
                     /transl_table=11
                     /translation="MNRKLSVPIVAACLVLALGPGSLAVATPLSGLPEAAQAAPYCYEE
                     PSQPQADISDLKARFNRSNWMPTLQAMYKRRWPSGEKLAIAQAKDKYWNQFVDTSSFDA
                     FAESMMVAIHEETHMWDLDGARTVWDVRTASWVNATQQILDIPLHGGFPRKEILPLIKD
                     KLSDDMDGIYLRDRQQGDYRLQGVLAELNAGLTGLPAVTVVQEYIKGIGASNARDIAAT
                     NLRYLLLYLRVAKDKHPDYWAKIKNEPKVRELVLTQFLRTAYWLEKSAPYTGKLGSPDA
                     DKITAKNYAPENISILEEFTGRKVRTDAQKNCTVS"
     gene            complement(2319..3311)
                     /locus_tag="O3I_RS14760"
                     /old_locus_tag="O3I_014575"
     CDS             complement(2319..3311)
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008712851.1"
                     /locus_tag="O3I_RS14760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014575"
                     /product="DMT family transporter"
                     /protein_id="WP_041562614.1"
                     /transl_table=11
                     /translation="MTTIAHDSAVRRRLRSGLLFALLSASSFGLSGSLARGLMNAGWSA
                     ASVVAVRVLIAAVVLLPIAVVQLRGDWQLLRRNASLIIAYGLLAVAGTQLAYFNAVAEM
                     EVGVALLIEYTAPIAVVGWLWLRHRQRPGVATVAGGLLGIVGLALVIDLRSGLSTSWVG
                     IAWALAAMIGAAAYFVLSAQGEGTLPGTVLAAGALLIGGLTLLAAGAIGLVPLHATTNP
                     VVFQDFTASPWPVLLILGTVTAALAYVSGIVATRLLGSRLASFVALFEVLAALAFAWVL
                     LGEAPRAIQLLGGILILTGVVVVRRGELTDAAHTPPVDAAPSEVVPEHR"
     gene            3350..3880
                     /locus_tag="O3I_RS14765"
                     /old_locus_tag="O3I_014580"
     CDS             3350..3880
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019049384.1"
                     /locus_tag="O3I_RS14765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014580"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_014983732.1"
                     /transl_table=11
                     /translation="MTFAHDTEVSLLAAVELVNSAEEPDTLTEIAQLEEFFVRHVYTGV
                     RTGDAAELAAVRAQRAPLRTLLTSDRDTAVRLVNETLAKHRATPQLVRHDGFDYHIHAV
                     SPDAPLPVRIAVETAMAMVDLIRSDELSRLSLCADSACEGIVLDLSRNRSRRYCSTACG
                     NRNAVAAYRARRR"
     gene            complement(3877..4425)
                     /locus_tag="O3I_RS14770"
                     /old_locus_tag="O3I_014585"
     CDS             complement(3877..4425)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011207714.1"
                     /locus_tag="O3I_RS14770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014585"
                     /product="YaeQ family protein"
                     /protein_id="WP_014983733.1"
                     /transl_table=11
                     /translation="MALSATLHNFTVQLADVDRDVYQELDLRLARHPSETAEFMLTRLL
                     AYCLEYQEGIAFSDGGVSSTEEPAVLVRDLTGRLLAWIEVGAPDAERLHRGSKAAERTA
                     VYTHRDPAKVLAQLAGKRIHRAAEIPLYSFDRDFIDAAVAAVERRNTVTLSVTERALYL
                     DLNGTGCSTSVEEHTIGQP"
     gene            complement(4438..5001)
                     /locus_tag="O3I_RS14775"
                     /old_locus_tag="O3I_014590"
     CDS             complement(4438..5001)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS14775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_014590"
                     /product="hypothetical protein"
                     /protein_id="WP_041562615.1"
                     /transl_table=11
                     /translation="MGNVENDSLAGEVMGQAAPTRWRRGMAASVAALAALGLVGAAAGS
                     ATAAPATACLWAGTDYAQGAQVTAGGRIFSCATDHGTPVWVRGAATGAPSTVANPGSRT
                     RPTGTFSLGAQQPGTEYNDYCVGSQLIDGSAAVYQVVADGAGALRWQAAGPITQWVFAP
                     GTGPVPTTRSASLCPAEPVLWPPN"
     misc_feature    4976..4990
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    complement(4978..4989)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            complement(5267..5692)
                     /locus_tag="O3I_RS14780"
                     /old_locus_tag="O3I_014595"
     CDS             complement(5267..5692)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS14780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_014595"
                     /product="hypothetical protein"
                     /protein_id="WP_014983735.1"
                     /transl_table=11
                     /translation="MLAIAGPAIAADSLWTFPVAVLLMFLLDAMFRAFLPEIATPLGYR
                     TNDTCSTRTVLLSSAGHAVLAVALAGIVAVSGVGDLPGAAVLGAVLGLIAGVPVAVFLG
                     QEAGVPRAIAALHGVHWMLKLFIGTYAVADGVLQALN"
     gene            complement(5715..7175)
                     /locus_tag="O3I_RS14785"
                     /old_locus_tag="O3I_014600"
     CDS             complement(5715..7175)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF006596.0"
                     /locus_tag="O3I_RS14785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014600"
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_202804935.1"
                     /transl_table=11
                     /translation="MSVFSRRTPLISVAALGLVAALTASACSSDSDSAAKNETNSSSSA
                     TTQDNTKLFHEIYKQLVETDTSHSTGSTTVAADAVKRRLLDAGFAESDIQIFEPVARKG
                     NLVLRFTGTGQRKPLLLLGHLDVVEAKREDGWTTDPYKLTEVDGFYAARGAIDDKAMVS
                     ALVSGLMQLKREGFKPNRDIVLALTADEEAGKDNGAKWLMENKADLMSAEYGLNEGGRA
                     LLVDGKPTLQGVQVAEKTYVTYQVEAKENGGHSSVPTPDNAIYTLGAALNRLAAYRFPA
                     SLSDATRDNFGALAASRSGPEAEDMRAVAAGNPSPEAIERLSALPEYNAQLRTTCVATM
                     LTAGEAENALPQKAKATVNCRILPQDNPDDIDKQLRAAFADGGKLTITRNLDPAGGISP
                     INGDVLAAVTSLTKELFPTAAVSSFMSTGATDSKYARSKGIPMYGVSGLFMVPADAGRI
                     HGINERAPIAGLEASREFLYRLVKQLAQ"
     gene            complement(7229..9154)
                     /locus_tag="O3I_RS14790"
                     /old_locus_tag="O3I_014605"
     CDS             complement(7229..9154)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="O3I_RS14790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014605"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_014983737.1"
                     /transl_table=11
                     /translation="MGTTESAGDPLVGVDELSTPSWMTVDKQVAEAGLGRTLLALPAGA
                     RVVIGLAWQASRRWTLLTAVLAVASGAATAFGLLATADVLTTLLAQGPTSHRVVSALPA
                     VGAVVAALAARALIESGTATAEALLKPRVEQRARDRAHTAIARVDLIAFEDSEYADLVR
                     QGLQRGMGSIGRCVEAITDLSGALVHVCAAVGAAAVLHPALAPLVLLAVLPDVWASARA
                     AKLSYQSYVRLVTRQLRTALASELLSDRETAAELRACTAGPALLGEYRRISTQITTETS
                     RVELAKARVRLAGRAIAGLGTGAAYGVLGLLLYLDALPLALAGTAVVAMRMATAALSQT
                     MIGVNSLYENILYLDFYSNLLEQTQRRTRPVSHRTAPADPHEITLHAVSFTYPGQDEPA
                     LRTVELSIRRGEVVALVGENGSGKSTLARLLTGLYLPTTGRVCWDGVDLATVDEQSIYR
                     NVAVVMQDPARWPMSARDNIRIGRIECVDPAAALREAARKSGADAVIDELPSGEATVLS
                     RRFARGRDLSGGQWQRISVARGLFRDAPVLVADEPTAAMDARAEHAVFESLQELSRGNG
                     REPGNRTTILITHRLANIRHADKIVVLDHGRIAEVGTHGELMAADGGYAQLFALQAAAY
                     QLEPTT"
     gene            9428..9607
                     /locus_tag="O3I_RS14795"
     CDS             9428..9607
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS14795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_041562616.1"
                     /transl_table=11
                     /translation="MSAPVDDFDLDIRIGDPSRLLDPAMAARTSDFETCADSHCATCGS
                     ACNTEHPPRCTKYC"
     gene            9624..9803
                     /locus_tag="O3I_RS14800"
     CDS             9624..9803
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="O3I_RS14800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_041562617.1"
                     /transl_table=11
                     /translation="MSVPVDEFDLDIRIGDPARVVEPGMVTKTTDAEWCSDSHCPTCGT
                     TCPTHHGPRCTANC"
     CDS_motif       9624..9695
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSVPVDEFDLDIRIGDPARVVEPG"
                     /locus_tag="O3I_RS14800_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9696..9803
                     /prepeptide="core"
                     /locus_tag="O3I_RS14800_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.30"
                     /molecular_weight="3573.0"
                     /monoisotopic_mass="3570.5"
                     /core_sequence="MVTKTTDAEWCSDSHCPTCGTTCPTHHGPRCTANC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSVPVDEFDLDIRIGDPARVVEPG"
                     /leader_location="[9623:9695](+)"
                     /alternative_weights="3591.0"
                     /alternative_weights="3609.0"
                     /alternative_weights="3627.0"
                     /alternative_weights="3645.0"
     gene            9819..9986
                     /locus_tag="O3I_RS45530"
     CDS             9819..9986
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS45530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_156161479.1"
                     /transl_table=11
                     /translation="MSYPVDEFDLDVRLGELSGAVPEYGTTAAYPPPTTVHCPTDRSRC
                     CPLPGVDFEY"
     gene            10001..11314
                     /locus_tag="O3I_RS42635"
                     /old_locus_tag="O3I_014610"
     CDS             10001..11314
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="O3I_RS42635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014610"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_014983738.1"
                     /sec_met_domain="LANC_like (E-value: 7.1e-50, bitscore:
                     168.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNADRASVIVDELHPAGRPWRSLLPADLAASAIAVSVEVGKRLRD
                     TASTPESGSAGCAVLFDQLDRLGPDHGWAVHSHACLTAAARTAERAERGRLGLFGGLCE
                     VAFAADALSRDGTRYQRLLDDLDEVIARAAAALGATIAAQPTGLPSAAFDVIAGLAGAG
                     AYLLRRTGRPHIDDALREVLAGLTALCGTSDGVPNWHTLPAAMVPNSPMARAYPTGVFN
                     CGLAHGVPGPLAVLALAESAGISVPGQRAAVARVAHWLVAQRRDDAWGPNWPTGVALPD
                     PTGTAPTAYGPTHNAWCYGSPGVARALWSAGAALADPQLGELAVRTLRAVYRRTPDARR
                     IDGSPGLCHGVAGLLQITLRFAADTGDPDCVAAVPVLTARLLSMFQPERRYGYLSIAEN
                     GPTADDPGLLDGAAGVALALLAAATDLPPTWDRTLLLS"
     gene            11329..12588
                     /locus_tag="O3I_RS14810"
                     /old_locus_tag="O3I_014615"
     CDS             11329..12588
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="O3I_RS14810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014615"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_081593990.1"
                     /sec_met_domain="LANC_like (E-value: 7.2e-49, bitscore:
                     165.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWGSVLPAAMAAEAVAVARTVARRLAAPESLPPLPDRPALLRDG
                     ASGAAGCAVLLSRFDGSEGERAAHRCLTAAVRELEHADVRPPGMFDGLTGLAFSALLLS
                     RNGTRYQRLLAELDRGIVRDATSRAAVLAHARHGLPFESFDLVSGITGTGAYLLRRNAY
                     PAALRSALTGLVAVCRWDTDLPNWHTPAWSIAPKTPMAESFPGGVLNCGLAHGVPGPLA
                     LLSLAELSGISVPGQGEAIAVVGHWLAAHRADDAHGPNWPTGIPLPGTAAVETRSRNAW
                     CYGGPGVARALWLAGNAIDDTELRSLAVEAMLAASSRFAATAETDPAPGLCHGVAGLLQ
                     IMLRFAHDTGDPRFARAAVELTDRLLARYDPAHRFGFRCAGELPADRPGLLDGAAGIAL
                     ALLAASTGEMPDWDRMLLLA"
     gene            12598..15714
                     /locus_tag="O3I_RS14815"
                     /old_locus_tag="O3I_014620"
     CDS             12598..15714
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="O3I_RS14815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014620"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_014983740.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7e-179, bitscore:
                     595.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-14,
                     bitscore: 53.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.8e-43, bitscore:
                     147.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTGSNLYRPLDWLVVRTPLLPLGEYLALGADPAADWPARTAPG
                     TLVPADPRVQRSLAVGGGELLRALERPCADVRARQRLAGKLQRYLIRMSSRPTPFGMFA
                     GVGLAGWGPATDLELADAPAVLRTRPDMGWLLDFVQTLEQRDEIRAQLRLCSNPAAFVQ
                     ADRVFLSERTPIGEAAESGRAMSLRATTPVRRALERARTPTRYRDLVDELAAELGASAD
                     RVRGLLDQLCEQTLLLTDLRPPVTAADPAGYVARRLAEIPAAGPAAAALGELLEQLGDW
                     DRLDHDQAAAGYPKLLDRAHSVHAVATPKGPFQTDMSRPFTGRQVHAAVATEAVRAAEL
                     TIRLSSWPAGTAELDSYRAAFTERYGPDREVGLLELLDPEIGLGAPRKADKGGADDERR
                     QVRHRTLTDLALDAIRERKSVVELDAATIAKLELQSAELTKAPASLDISLFVVADSAAA
                     VDAGEFQVVVGPNLGASTAGRVLGRFADLIGPSAEQALHEAAAAEAQCRPGRLWAEVSY
                     LPRPGRLANVTIRPLARAWELPFDTTPGAPAERVIPLSELVVGLRNGRFVVRWPRTGQE
                     VVTCAGHMLNAQVAPAVVRFLDEINRDGRPVPMTFDWGPATGFPFLPRVQAGRVVLAPA
                     RWRVPADDLAPKAAASFAAAFAAWRQRWQPPRHLYLAMADHRLLLDLDAPDQVEQIRDE
                     ARRTPGGKLYLEEALPGPGHAWLPGPDGHYLSELVVPLVRTAVEPEPVRGQARSVPPTT
                     SVARLRPPGSDWLFAKLYHVPTFEEDLLAHQIRDFCAQAVADGSADNWFFLRYTDPDPH
                     LRIRWHGDPDRLTDRLAPALLRWGSRLVTDGYCRRVSVDTYDQEVERYGGPAGTAVAED
                     LFAADSAAVLELLALVDRRIVTLDRRLLAMVTVDDLVTAFGLTQAEQIDLYRNGVLERR
                     ATADEYRRENATFRSLLGDRRWLASQPGGSAVAEILNRRRILLQAAASRLDLLANRGEL
                     TRSRPELVRSFVHMHCNRLLGCGHPPEQRVLGLLWRTRESLRHAPVALS"
     aSDomain        13057..13329
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O3I_RS14815_Lanthipeptide_LanB_RRE.1"
                     /evalue="4.40E-17"
                     /identifier="RREFam001.1"
                     /label="O3I_RS14815"
                     /locus_tag="O3I_RS14815"
                     /protein_end="244"
                     /protein_start="153"
                     /score="53.6"
                     /tool="antismash"
                     /translation="LCSNPAAFVQADRVFLSERTPIGEAAESGRAMSLRATTPVRRALE
                     RARTPTRYRDLVDELAAELGASADRVRGLLDQLCEQTLLLTDLRPP"
     misc_feature    14722..14724
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15707..16375)
                     /locus_tag="O3I_RS14820"
                     /old_locus_tag="O3I_014625"
     CDS             complement(15707..16375)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="O3I_RS14820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014625"
                     /product="response regulator transcription factor"
                     /protein_id="WP_041563818.1"
                     /transl_table=11
                     /translation="MTEAPVPQITVVLADQHAVVRAGLRSMLAAVAEFTIVGEAATVSE
                     LTRQALRERPDVVVLGLLLSQERTHRVITDILRSCPGLAVLVFGMDEDDGAVRAAINAG
                     ARGYVDKSSTAEGIVRAVAGAAAGWAVFSPGSAEALARITAQPATVEVVAFADLTVRER
                     EVLELVAAGLSNAAIAGRLHLASKTVSNYLSAIFLKLGVCDRANAILRAREAGFGVALS
                     "
     gene            complement(16578..20132)
                     /gene="dnaE"
                     /locus_tag="O3I_RS14825"
                     /old_locus_tag="O3I_014630"
     CDS             complement(16578..20132)
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaE"
                     /gene_functions="other (smcogs) SMCOG1194: DNA polymerase
                     III subunit alpha"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076409.1"
                     /locus_tag="O3I_RS14825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014630"
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="WP_202804977.1"
                     /transl_table=11
                     /translation="MLSSFVHLHVHTEYSMLDGAAKIKPLFDEAARLGMTAVGMTDHGN
                     MFGADEFYQHATKVGIKPVIGIEAYVAPGSRLHKKPVFWGQSGQRGANGEGIGGDVSGG
                     GAYTHMTMLARTAQGLRNLFALSSLASMEGYYRKPRMDRELIARHAAGIIATTGCPSGE
                     VQTRLRLGQHAEAMQAAADYRDIFGRESFFVELMDHGLPIERSVRDGLLEISRKLDLPP
                     LATNDSHYVRKDQAEAHAALLCVQAGKTLNDPTRFKFDGDGYHLRSAEEMRAYWDAQVP
                     GAADNTVAIAERVESYADVWQHRDRMPVYAPPPGHDVNSWFHAEVMRGLARPLPGGVTD
                     EYRHRAEFEIGIIVEKGFPAYFLITADLMEHARAEGIRVGPGRGSAAGSLVAYAMGITN
                     LDPIVHGLLFERFLNPERMSMPDIDMDFDDRRRGEMVRYATEKYGADRVAQVITFGKIK
                     TKAAIKDSARVHYGQAGFAIADRISKALPPPVAAKDIPLSGITDPAHERYPEAAEVRAL
                     LDTDRDVATIMDTARGLEGLIRNAGVHACAVIMSAEPLLHVVPLWRREDGAMITGWDYP
                     SCEAVGLLKMDFLGLRNLTVIGDAIDNIRANRGETVDLDTLGTDDAKTYALLGRGESLG
                     VFQLDGAAMRDLLRRLIPTGFEDIVAVNALYRPGPMAMNTHNNYADRKNDRQQIVPIHA
                     ELAEPLRDILAETYGLVVYQEQIMQIAQRVAGFSMGRADVLRRAMGKKKLDVLEKEFEG
                     FRAGMRDNGFSDEAVQALWDTVLPFAGYAFNKSHAAGYALVGYWTAYLKANYPAEYMAA
                     LLTSVADNKDKSAIYLSECRQLGIKVLAPDVNESSLRFAAVGTDIRFGLGGVRNVGANV
                     VESIIETRTRKGKYASFADFVEKSELVCCNKRVLESLIKAGAFDSFGHPRRALADIHED
                     AVDAVTGLKRQQAMGQFDLFGDGDAAAESSSPLAHLSFDAPEWPRDELLGLEREMLGLY
                     VSGHPLDGADHLLRKHAPKPIAALLANPPRDGTVTIAGMISALERRVNKKGESWAIAVI
                     EDLDATVEVLFFPKSYSLFAADLMVDAVVVVEGRVNWREDKLALFGAHLAALDLTHLDE
                     HRRQAPLTLEINARNTDRDSMRELKSVLLAHPGGTPVHLALCYRQRRTMLAIEDYPVTV
                     SPALLGELRAVRGVKVLT"
     misc_feature    complement(20195..20210)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            complement(20228..21172)
                     /locus_tag="O3I_RS14830"
                     /old_locus_tag="O3I_014635"
     CDS             complement(20228..21172)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="O3I_RS14830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014635"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_014983743.1"
                     /transl_table=11
                     /translation="MELDRGAVRAFLAIADHQHFGDAADQLKLTQQAISKRIAKLEAGL
                     GATLLQRTRTGTGLTEIGAAFLPQARALLALADQATAAVRERERPLRVDVLGTRLAATE
                     LIRAFHTAHPDFEIDIITSSGLRSGLPALVAGTIDVAFARAIGPLDTVITHIPAYFEPL
                     HILVGRKHPLANRRQVRLRELADSIARMPSNVPGSEWARFYDDLAAAFGLAIDTTGPDF
                     GLDHLLDDLARTSDSYVFTGERLRAPWHPEIVQLPVVDPAPGYPHSMLWHRDNQRPALR
                     QLAGYVAAGFRPFDPRTQWLPPAEAGGGRWDNN"
     gene            complement(21241..22014)
                     /locus_tag="O3I_RS14835"
                     /old_locus_tag="O3I_014640"
     CDS             complement(21241..22014)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (7-249). E-value: 1e-52. Score:
                     170.9. Matches aSDomain: nrpspksdomains_O3I_RS14835_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010541069.1"
                     /locus_tag="O3I_RS14835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014640"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_014983744.1"
                     /transl_table=11
                     /translation="MSSYVVTEQRARIGYLTLNRPDQRNPLSANMMAELTAALREFGGN
                     SEVAVVVIRAAGRAFCAGHDLGELVDRSLDDERALFAACIELMQTIQQIPQPVLASVQG
                     PAVAAGCQLVATCDLALATPDAVFGTPGVRIGLFCSTPMVAVSRAIGRKRAMQLLLTGA
                     VIDAPTAADWGLINDVVPADALAARTHELAESIAQASPSTLRIGKQAFYHQIDLPQPQA
                     YEQMGEVMATNAMTCDAQEGMHAFLEKRTPVWRGY"
     aSDomain        complement(21268..21993)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O3I_RS14835_ECH.1"
                     /evalue="1.00E-52"
                     /label="O3I_RS14835_ECH.1"
                     /locus_tag="O3I_RS14835"
                     /protein_end="249"
                     /protein_start="7"
                     /score="170.9"
                     /tool="antismash"
                     /translation="EQRARIGYLTLNRPDQRNPLSANMMAELTAALREFGGNSEVAVVV
                     IRAAGRAFCAGHDLGELVDRSLDDERALFAACIELMQTIQQIPQPVLASVQGPAVAAGC
                     QLVATCDLALATPDAVFGTPGVRIGLFCSTPMVAVSRAIGRKRAMQLLLTGAVIDAPTA
                     ADWGLINDVVPADALAARTHELAESIAQASPSTLRIGKQAFYHQIDLPQPQAYEQMGEV
                     MATNAMTCDAQEGMHAFLEK"
     gene            22170..22913
                     /locus_tag="O3I_RS14840"
                     /old_locus_tag="O3I_014645"
     CDS             22170..22913
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF005743.0"
                     /locus_tag="O3I_RS14840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014645"
                     /product="glutamine amidotransferase"
                     /protein_id="WP_014983745.1"
                     /transl_table=11
                     /translation="MPKPFLLLQLRPERAAADDEYHAILRAGELDAGDVVRVRMEEGFP
                     DLTLDDYAAVIVGGGPSNVGNADVEKYDYQRRFEPALKKLLTEIVSRDFPYLGACYGLS
                     VLADVLGGTVSTENYGETAGAQTIELTDDAREDPLLQGIPRNFRAFVGHKEACQAVPPE
                     AVLLAGSADCPVQMIRVARNIYATQFHPELDGDGLALRIEIYRHAGYFDPDEADYLTRL
                     GHQESITAPKQILRRFVLRYGGAAT"
     gene            complement(22923..23390)
                     /locus_tag="O3I_RS14845"
                     /old_locus_tag="O3I_014650"
     CDS             complement(22923..23390)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016694830.1"
                     /locus_tag="O3I_RS14845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014650"
                     /product="DUF6194 family protein"
                     /protein_id="WP_014983746.1"
                     /transl_table=11
                     /translation="MTIDEIIDLLTDLDGILVLAPAPGDGTPEIAWGDKFFYYSPDGVV
                     PTNTQPFATIVTKDYPDDQHSRLNRPDAFRLNISAGKDTFIETLGYPPREVPADLDYSS
                     TDVFLPHPTYAAAAWISVVDPAVRTSDSARRFLRAAYDRARSRYERRTATE"
     gene            23453..24160
                     /locus_tag="O3I_RS14850"
                     /old_locus_tag="O3I_014655"
     CDS             23453..24160
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011208809.1"
                     /locus_tag="O3I_RS14850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_014655"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_014983747.1"
                     /transl_table=11
                     /translation="MKNLNSQVMRTVDVARRAGYSVQQIRNLERDGVLPPAERTPTGHR
                     VYREVHLHAALAYRALAAGAGPVAAKQILRTVHTGSIAEALALLDAAHARLHVERVELA
                     HAKAAADAIAAEPIAAVRDSDSMTVSELAGALGVRTSTLRHWDAAGLVVPDRDRTARRY
                     TPSQVRDARIVHQLRRAGYRIPQLRNVLPELRRVHDASDVHAALAARDAVLASRSRALL
                     AAAASLHLLVVEV"
     misc_feature    24011..24013
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(24463..25676)
                     /locus_tag="O3I_RS14855"
                     /old_locus_tag="O3I_014660"
     CDS             complement(join(24463..25445,25445..25676))
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558251.1"
                     /locus_tag="O3I_RS14855"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="O3I_014660"
                     /product="IS3 family transposase"
                     /protein_id="WP_237748305.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MYAEIREQHESEWAAMGAVAELLGVGTPETVRKWVRQAQIDTGAR
                     PGVTSDESDELRRLRRENAELKRANAILKSASGFLRGRTGPATALTVRYISEHQGRRVE
                     GGLRWGVESICAALAELGVKIAPSTYYEHRDRMPTVRENRDQELIAEIGRVHAENFGVY
                     GARKVWLQLNREGIAVARCTVERLMRTAGLRGAVRGRVTRTTIADPAAVRPADLVRRRF
                     APTAPNRLWVADITYVRTWSGWVYVAFVIDAYARRVIGWRTATSMTTALVLDAIEHAIW
                     TRERQGWDIKDVVHHNDHGSQYTSIAFAERLAEAGIQPSVGAVGSSYDNALAETINGLF
                     KTELIKPRAPWRTVDQVELATAEWVDWFNHRRLYQHCGDIPPAEMETAYYAQQPARQPA
                     ELPQQ"
     misc_feature    complement(25098..25100)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gccggagaag gtcgcggacc tggtagccgc gggcgcggcc cgggcgcaga caccgcgtgc
       61 tgcggccgag caggccgacg ccgtcttcgc gatggtcgcc gacgatgccg cctcgcgcgc
      121 ggtgtggctc ggcgcggagg gtgccctcgc ggcggcgggc gcgcccggcc gattcgcgat
      181 cgagtgctcg accctgtccc ggccctgggt gctcgagctc gcgaaacagg ccgcgacgca
      241 gggattccgg tacatcgact cgccggtcac cgggctgccc acagctgcgg cggccggaga
      301 gttacgcctg ctgatcgggg ccgcgcccgc ggacctcgac gcggtgcgcc cgctgctgga
      361 accgttgtgc ggcagcatcg ttcacttcgg tgaggtcggc gcgggcaccg cgtacaaact
      421 ggtgcagaat ctgctgggct cggtgcagat cgccgcgacc gcggaggcgc tgcggatcgc
      481 cgaactcagc ggactcgacc tgcccgcggt ggtcgacacc ctcgcgctga gcgtcgcggc
      541 cagtccgacg gtgacgcggg tcagccggtt gatgctggac ggcgtgcacg accgcgatat
      601 cgcgttcacg gccgcgctgc gcttgaagga cacccgcatc gggatggaac tcgccgaggc
      661 cgtgcacgcg cccgccgcgc tggggcgtgc cgccttcgac ctcttcgggc ggctcgtcga
      721 ggcgggccac ggtgagctca acgaaaccaa ggtcatcgat cttttacggg aatgatcgcg
      781 ccgagcgcct agacttcgtt tcgaaaagga aggacagctc atgaagcgga acctgaattg
      841 cccgtgtggc gaggcgatcg tcggcgtgga cgaggacgat ctcgtcgaga agacacaggc
      901 tcacctcgcc gcgaaccatc cggggcacga gtactcgcgc gacgagatcc tgttcatcgc
      961 ttactgatcg aagcgtgcat agcggccgct gcgccgctgc gggcgaactg gggaggagtg
     1021 gggacatgcc actcctcgtc ccggtacgcc ctcagttcta gtgccgcaca ggctatttca
     1081 taatcacgct cacttctgcc gggcgcgcgg gtcgcggccg ggtgcgccgc gccgtcgact
     1141 gcttcgtttg cgcgacatat tgtctcgatt acattcgagc tcgagtgacc tcgccgcagc
     1201 gcgagtcgga tccccacacc gtgtgaaacg gcaaatccat tgccgcgcag ccgtgccggc
     1261 cgttcgcgct gtatcccgcc gccgtcgcgc ccgccgcgcg gctcctccga agtggggtcc
     1321 ctgtgaaccg caaactttct gtgcccatcg tcgccgcctg cctggtcctc gccctcggac
     1381 ccggttcact ggccgtagcg acgcccctgt ccggtctgcc cgaagcggcc caggccgcgc
     1441 cctactgtta cgaggagccg tcgcagccac aggccgatat cagcgacctg aaagctcgct
     1501 tcaatcggtc caattggatg ccgacgctgc aggccatgta caagcggcgc tggccgagcg
     1561 gggagaagct ggcgatcgcc caggccaagg acaagtactg gaatcagttc gtggacacca
     1621 gcagtttcga cgcgttcgcg gaatcgatga tggtggcgat ccacgaggag acgcatatgt
     1681 gggatctgga cggggcgcgc accgtgtggg atgtgcgcac cgcgtcgtgg gtcaacgcca
     1741 cccagcagat cctggacatt ccgctgcacg gcgggttccc gcgcaaggag atcctgccgc
     1801 tgatcaagga caagctcagc gacgacatgg acggcatcta cctgcgggac cggcagcagg
     1861 gcgactatcg cctgcaaggc gtcctcgccg agttgaacgc ggggctgacc ggtctgcccg
     1921 cggtcaccgt ggtgcaggag tacatcaagg ggatcggtgc gagcaatgcc cgcgacatcg
     1981 ccgcgaccaa tctgcggtac ctgctgctgt acttgcgtgt cgccaaggac aagcacccgg
     2041 actactgggc gaagatcaag aacgaaccca aggtgcgtga gctggtgctg acccagttcc
     2101 tgcgcaccgc ttactggttg gagaagtccg cgccctacac cgggaagctc ggcagtccgg
     2161 acgcggacaa gatcaccgcg aagaactatg ccccggagaa catctcgatt ctcgaggaat
     2221 tcaccggacg caaggtgcgc accgacgcgc agaagaattg caccgtctcc tgaacgggcc
     2281 cggccgggat cgccgacggt gctcccggcc gttcgggatc agcggtgttc cggcacgacc
     2341 tcgctcggcg cggcgtcgac gggcggggtg tgggccgcat cggtcagctc gccgcggcgc
     2401 acgaccacca cgccggtgag aatcaggatg ccgccgagca attggatcgc ccggggcgcc
     2461 tcgccgagca gcacccaggc gaaggccagc gcggcgagta cctcgaacag ggcgacgaac
     2521 gaagcgagcc gggagccgag caggcgggtg gcgacgatgc cggagacgta ggccagggcc
     2581 gcggtcaccg tgcccaggat cagcagcacc ggccaggggg atgcggtgaa gtcctggaag
     2641 acaacgggat tcgtggtggc gtgcagcggg acgagcccga tcgcacccgc ggcgagcagc
     2701 gtgagtccgc cgatgagcag cgcgcccgcc gcgaggacgg tgcccggcag cgtgccctcg
     2761 ccctgtgcgg agagcacgaa gtacgcggcg gcgccgatca tggcggccag ggcccaggcg
     2821 atgccgaccc agctggtgga cagcccggac cgcaggtcga tcacgagggc gaggccgacg
     2881 atgccgagta ggccgcccgc gacggtggcg acgccggggc gctgccgatg gcgcagccag
     2941 agccagccga ccaccgcgat cggggcggtg tactcgatga gcagcgctac cccgacctcc
     3001 atctcggcga ccgcgttgaa gtaggccagc tgtgtgcccg ccacggccag caagccgtag
     3061 gcgatgatca gggatgcgtt gcggcgcaac agctgccagt cgccgcgcag ctggacgacg
     3121 gcgatcggca gcaacacgac ggcggcgatg agcacccgga ccgccaccac cgacgcggcg
     3181 ctccatcccg cgttcatcaa gccgcgcgcc agggagccgg agagtccgaa cgacgacgcg
     3241 gacagcagcg cgaagagcag cccggatcgc aaacgccgcc gtacggcact gtcatgagca
     3301 atggtcgtca tgggtaatga cgctaaggcg gtgtatgtaa gatgtcaaca tgacttttgc
     3361 tcatgacacc gaggtatcgc tgctggccgc ggtcgagctg gtcaattcgg ccgaagaacc
     3421 cgatacactg accgaaatcg cccagctgga agagtttttc gtcaggcacg tctacaccgg
     3481 cgtgcggacc ggcgacgccg ccgaactcgc ggcggtgcgc gcgcagcgcg ccccgctgcg
     3541 cacgctgctg accagcgatc gggacaccgc ggtgcggttg gtcaacgaga ccctcgccaa
     3601 gcatcgggca acgccgcaac tggtccgcca cgacgggttc gactatcaca tccacgcagt
     3661 ctcgccggac gcgccgctac cggtgcgcat cgcggtcgag accgcgatgg cgatggtcga
     3721 cctcatccgc tccgacgagc tgagcaggct ctcgctctgt gccgacagcg cgtgcgaggg
     3781 catcgtgctc gatctgtccc gcaatcgatc ccggcgctac tgcagtaccg cgtgcggcaa
     3841 ccgcaacgcg gtcgccgctt atcgggcgag gcggcgctag ggctggccga tggtgtgttc
     3901 ctccaccgag gtgctgcatc cggtgccgtt gagatcgagg tagagcgcgc gttcggtgac
     3961 cgacagggtg acggtgttgc ggcgttcgac ggcggcgacg gccgcgtcga tgaagtcccg
     4021 gtcgaagctg tagagcggga tctcggcggc acggtggatg cgctttccgg cgagctgtgc
     4081 gagcaccttc gccggatcgc gatgggtgta gacggcggtg cgttcggccg ccttgctgcc
     4141 gcggtgcagc cgttcggcgt ccggggcgcc gacctcgatc caggcgagga gccggccggt
     4201 gaggtcgcgc accagcaccg ccggttcttc ggtggaggac acgccaccgt cgctgaacgc
     4261 gatgccctcc tgatattcga ggcagtaggc cagcagccgg gtcagcatga actccgcggt
     4321 ttcggacgga tgccgcgcca accgcaggtc cagttcctgg tagacgtcgc gatcgacgtc
     4381 ggccagctgg acggtgaagt tgtgcagggt tgcgctgagg gccatagggc caggagctta
     4441 gttcggcggc cagagcaccg gctcggccgg gcagaggctg gccgagcggg tggtcggcac
     4501 cggtccggta ccgggggcga acacccactg ggtgatcggt ccggccgcct gccagcgcag
     4561 cgcgcccgcc ccgtccgcga ccacctggta cacggccgcg ctaccgtcga tcagctgact
     4621 gcctacgcag tagtcgttgt attcggtgcc cggttgctgc gcgccgaggc tgaacgtgcc
     4681 ggtggggcgg gtgcgcgaac cgggattcgc gacggtgctc ggtgcgccgg tggccgcgcc
     4741 gcgcacccag accggtgtcc cgtgatcggt cgcgcagctg aagatccggc cgccggccgt
     4801 cacctgcgca ccttgtgcgt aatccgttcc ggcccacagg catgcggtgg cgggcgcggc
     4861 ggtcgcgctg cccgccgcgg ccccgaccaa cccgagtgcg gcgagcgccg ccacggacgc
     4921 ggccatgccg cgacgccacc gcgtcggcgc ggcctgaccc atgacttcac cagcgagaga
     4981 atcgttttcc acgttgccca tgcctcgaag gtaggaatcg aacggcctcg cccgaatccc
     5041 accgcagcgc cattccgggc tgatactgcg gtggtagggg tgcaacccgg ataacacccc
     5101 tgaccggaac ccggagtggc gcgggcgttc ccgcgcccgc gacggacgga aagcccagct
     5161 ggcgactcgg ccggcggccg cacggaccct gaccgcgatt ccggcaccgg cggccgatcc
     5221 tcaggcggta cgggaaaatt cagggcggcg ggacgtgagt ccgcggctag ttcagcgcct
     5281 gtagcacgcc gtcggctacg gcgtaggtgc cgatgaacag cttcagcatc cagtgcacgc
     5341 cgtgcagcgc ggcgatagcc cggggcacgc cggcttcctg tccgaggaag accgcgaccg
     5401 gcaccccggc gatcagaccg agtaccgcgc cgagcaccgc cgcgccgggc aggtcgccga
     5461 cgccgctgac cgcgacgatg cccgcgagcg ccacggccag cacggcatgt ccggccgagc
     5521 tgagcagcac cgtccgggtg gagcaggtgt cgttcgtgcg atacccgagc ggtgtcgcga
     5581 tctccggcag gaacgcccga aacatcgcgt ccagcaagaa catcagcagg acggcgaccg
     5641 gaaaggtcca gagcgaatcg gcggcgatcg ccggtcctgc gatggcgagc acgggatatc
     5701 ggtggcggtc gaagctactg ggcgagctgt ttcaccaagc gataaaggaa ctcacggctg
     5761 gcttccagcc cggcgatcgg cgcgcgctcg ttgatgccgt gaattcgccc ggcgtcggcg
     5821 ggcaccatga acaatccgct caccccgtac atcgggatgc ctttgctccg tgcgtacttg
     5881 ctgtcggtcg cgccggtgga catgaaggaa ctgacggccg cggtgggaaa cagttccttg
     5941 gtcaacgacg tgaccgcggc gagcacgtcg ccgttgatcg gcgagatacc gcccgccgga
     6001 tcgagattgc gggtgatggt cagcttgccg ccgtcggcga acgccgcgcg caactgcttg
     6061 tcgatgtcgt cggggttgtc ctgcgggaga attcggcagt tgaccgtcgc cttggccttc
     6121 tgcggcaacg cgttctccgc ctcgcccgcg gtgagcatgg tcgccacgca ggtggtccgc
     6181 agctgggcgt tgtactcggg cagggccgaa agccgttcga tcgcctccgg actcgggttg
     6241 cccgcggcga ccgcgcgcat gtcctcggct tccggcccgc tgcgactggc ggccagcgcg
     6301 ccgaagttgt cccgggtcgc gtcgctgagc gaggccggga accggtaggc ggcaaggcga
     6361 ttcagcgcgg cgccgagggt gtagatggcg ttgtccggcg tcggcaccga actgtgcccg
     6421 ccgttctcct tggcttcgac ctggtaggtc acataggtct tttcggccac ctgcacgccc
     6481 tgcagagtgg gtttgccgtc gacgagcaga gcccggccgc cttcgttgag cccgtattcg
     6541 gcgctcatca ggtcggcttt gttctccatc agccatttcg cgccgttgtc tttaccggcc
     6601 tcttcgtccg cggtgagcgc gagcacgata tcccggttcg gcttgaaccc ctcgcgcttc
     6661 agctgcatca ggccggacac cagcgccgag accatggctt tgtcgtcgat cgcgccgcgg
     6721 gccgcgtaga agccgtccac ctcggtgagc ttgtacggat cggtggtcca gccgtcctcg
     6781 cgcttggcct cgaccacgtc gaggtggccg agcagcagca acggtttgcg ctggccggtg
     6841 ccggtgaaac ggagcaccag gttgcccttg cgggccacgg gctcgaagat ctggatatcg
     6901 gactcggcga atccggcgtc gagcagccgc cgtttgaccg cgtcggcggc cacggtggtg
     6961 ctgccggtgg aatgtgaggt atccgtctcc accaactgtt tgtagatctc gtggaagagt
     7021 ttcgtattgt cctgcgtcgt cgcgctcgac gacgagttcg tctcgttctt cgcggcggaa
     7081 tcggaatccg agctgcaggc ggatgcggtg agcgccgcga caagtcccag tgcggccacc
     7141 gaaatcaacg gggtacggcg actgaataca gacacgtgct gaagctagca cggcccctgg
     7201 tgcttcgcgg ggggaacgac tatcgcgcct aggtggtcgg ttccagctgg taggcggcgg
     7261 cctgcagggc gaacagttgc gcgtacccgc cgtccgcggc catgagttca ccgtgtgttc
     7321 ccacctcggc gatgcggccg tggtcgagca cgacgatctt gtcggcgtgc cggatattgg
     7381 ccaggcggtg ggtgatcagg atggtggtgc ggttgcccgg ctcccggccg ttgccgcggc
     7441 tgagttcttg cagggactcg aacaccgcgt gctcggcgcg cgcgtccatg gccgcggtcg
     7501 gctcgtccgc caccagcacc ggcgcgtcgc gaaaaagccc gcgcgccaca ctgattcgct
     7561 gccactggcc accggacaga tcccggcccc tggcgaagcg ccgggaaagg acggtcgcct
     7621 cgcccgacgg cagctcgtcg atgaccgcgt ccgcaccgga ctttcgtgcc gcctcgcgca
     7681 gcgccgccgc cggatccacg cactcgatcc ggccgatgcg gatgttgtcc cgcgcgctca
     7741 tcggccagcg cgccggatcc tgcatgacca ccgcgacatt gcggtagatc gactgctcgt
     7801 cgacggtggc caggtcgacc ccgtcccagc acacccggcc ggtcgtcggt aggtacaggc
     7861 cggtgagcag gcgagccaaa gtgcttttgc ccgagccgtt ctcgccgacc agggcgacga
     7921 cctcaccgcg cctgatggat agctccaccg tccgcaacgc gggttcgtcc tgacccgggt
     7981 acgtgaacga gaccgcgtgg agcgtgatct cgtgcgggtc ggccggggcg gtgcggtgcg
     8041 agacgggccg cgtgcgccgc tgcgtctgct ccagcaggtt cgaatagaaa tcgagataga
     8101 ggatgttctc gtacaggctg ttcacgccga tcatggtctg cgacaaagcg gcagtggcca
     8161 tccgcatcgc gacgaccgcg gtgccggcca gagccagggg cagtgcgtcg aggtagagca
     8221 gcagtccgag tacgccgtag gcggcgccgg tgccgagacc ggcgatcgcg cgcccggcca
     8281 accgcacccg tgccttcgcc agttcgaccc ggctggtctc cgtggtgatc tgggtgctga
     8341 tccggcgata ctcgccgagc agggccgggc ccgcggtaca cgcgcgcagt tcggcggcgg
     8401 tctcccgatc ggagagcagt tcgctcgcga gcgccgtgcg cagctgccgg gtcaccaggc
     8461 gcacatacga ctgataggag agtttcgcgg cgcgggccga ggcccatacg tcgggcagca
     8521 ccgccagcag taccagcggg gcgagcgcgg gatgcagcac cgcggccgcg cccaccgccg
     8581 cacatacgtg gacgagcgcg ccggacagat cggtgatcgc ctcgacgcaa cggccgatgc
     8641 tgcccattcc gcgttgcagg ccctgccgga ccaggtcggc gtactcgctg tcctcgaaag
     8701 cgatcaggtc gacgcgggcg atggcggtgt gcgcccggtc ccgcgcccgc tgttcgaccc
     8761 gcggcttcag cagggcttcg gctgtggcgg tgccgctttc gatgagcgcg cgggccgcga
     8821 gcgcggcgac gaccgcgccg accgcgggca gcgccgacac cacccggtgc gacgtcggcc
     8881 cctgcgcgag caaggtggtc aggacatcgg cggtggccag caacccgaac gcggtcgcgg
     8941 cgccgctcgc caccgcgagc accgccgtga gcagggtcca gcgccgggaa gcctgccaag
     9001 ccaggccgat caccacgcgg gcgccggcgg gcaaggcgag cagcgtgcgc cccagcccgg
     9061 cctcggccac ctgtttgtcc actgtcatcc agctcggtgt gctcagctcg tccacgccga
     9121 cgagcgggtc gcccgcggat tcggttgtac ccatgcggtt ctcggccttc gtcgcgtcgc
     9181 cccgtagtcg caccaccgat ccaggttggt ccgtcggtgc tcccgcccgg cagaggcggc
     9241 ggccgggaaa gatcgggaaa tcgtcccggc tcgccggggc cggctgctct gtcgcccagg
     9301 gattcccgtg ccgcacggtg ggagacgtgt attccacggc ggtagccgaa ggcgcctgtc
     9361 cctccgacga ctgcagtagc tatccgatgt gcaagaccac cgaacggact tgctgaaaga
     9421 aggaaccatg tccgcaccag ttgatgattt cgatctcgat atccggatcg gcgacccgag
     9481 ccgattgctc gacccggcca tggccgcgcg gacctcggat ttcgagacgt gtgccgattc
     9541 gcattgcgcg acctgcggct ccgcctgcaa taccgagcat ccgccgcgct gtaccaagta
     9601 ctgctgacct ctaggagaac gaaatgtccg tgcccgtaga cgaattcgac ctggacatcc
     9661 gcatcggcga cccggcccgc gtggtcgagc ccgggatggt gacgaaaacg accgacgccg
     9721 agtggtgcag cgattcgcac tgcccgacct gcggtacgac ctgtccgacg caccacggcc
     9781 cgcggtgcac ggccaactgc tgaccacgag gaggcgagat gtcttacccg gtagacgaat
     9841 tcgatctcga cgtgcggctc ggtgagcttt ccggtgcggt gccggaatac gggacgacgg
     9901 cggcctatcc gccgcctacc acggtgcact gcccgaccga ccgcagcagg tgttgccccc
     9961 tgcccggtgt cgatttcgag tactgagagg aaccgccgga atgaacgcgg accgtgcgtc
    10021 ggtgatcgtc gatgaactcc acccggccgg gcggccgtgg cgcagcctgt tgcccgccga
    10081 cctggcggca tcggcgatcg ccgtatccgt ggaagtcggg aaacggctgc gggatacggc
    10141 atcgacgccg gagtcgggca gcgcggggtg cgccgtgttg ttcgaccagc tggaccggct
    10201 ggggccggac cacggttggg cggtgcattc gcatgcctgc ctgaccgctg ccgcgcgcac
    10261 cgccgaacgg gccgagcgcg gacggctcgg cctgttcggc ggattgtgcg aggtggcctt
    10321 cgccgccgac gcgttgtccc gcgacggcac ccgctatcag cggctgctcg atgacctgga
    10381 cgaggtgatc gcccgggcgg cggccgcgct cggcgcgacg atcgccgcgc aacccaccgg
    10441 cctgccgtcg gcggccttcg atgtgatcgc cggattggcc ggtgccggag cttatctgtt
    10501 gcgccgcacg ggccggccgc acatcgatga cgccctgcgc gaggtgctgg cgggactcac
    10561 agctttgtgc ggcaccagcg atggtgtccc gaactggcac acgctgcccg ccgcgatggt
    10621 gccgaacagc ccgatggccc gtgcctatcc caccggtgtg ttcaattgcg ggctggcgca
    10681 cggtgtcccg ggcccgctgg cggtgttggc gctcgccgag tcggcgggta tctcggtacc
    10741 cggtcagcgt gcggcggtcg cacgggtcgc gcactggttg gtcgcgcagc gccgcgacga
    10801 cgcgtggggg ccgaactggc cgacgggggt ggcgctgccg gatccgaccg gcacggcgcc
    10861 gaccgcctac ggccccacac acaacgcgtg gtgttacggc agcccgggcg tcgcacgagc
    10921 gctgtggtcg gcgggcgcgg cactggccga tccgcagctc ggcgagctcg cggtccgcac
    10981 cctgcgcgcg gtgtatcgcc gcacgccgga cgcgcgacgg atcgacgggt cgcccggcct
    11041 gtgccacggc gtcgccggcc tgttgcagat caccttgcgt ttcgccgccg acaccggcga
    11101 tcccgactgt gtcgccgcgg tgcccgtctt gaccgctcgg ctgctctcga tgtttcagcc
    11161 ggaacgccgg tacggctatc tctcgatcgc cgaaaacggc cccaccgcag acgatcccgg
    11221 gctgctggac ggtgcggcgg gcgtcgcgct cgcgctgctc gccgccgcca ccgacctccc
    11281 accgacgtgg gaccgaaccc tgctgctgtc ttgacccggg cctcgacgat gacgtggggg
    11341 agcgtgttgc ccgcggcgat ggcggccgag gcggtcgcgg tcgcgcggac ggtcgcgcgc
    11401 cgcctcgcgg cgccggagag cctgccgccg ttgccggacc ggccggctct gctgcgcgac
    11461 ggcgcatccg gcgccgccgg atgcgcggtg ctgttgagcc gattcgacgg cagcgaaggg
    11521 gagcgcgccg cccaccgctg cctcaccgcg gccgtacgcg agctggagca cgccgacgtc
    11581 cggccgcctg gcatgttcga cgggctgacc ggcttggcgt tcagcgcatt gctgttgtca
    11641 cgtaacggga ctcgctatca acgcctgctc gccgagctgg accgcggcat cgtgcgtgac
    11701 gcgacgagtc gcgcggcggt gctggcgcac gcccggcacg gtctgccgtt cgagtcgttc
    11761 gacctcgtct ccggtatcac cggcaccggc gcatacctgt tgcggcgcaa cgcctacccc
    11821 gccgcactgc gttcggcgct gaccggtctg gtcgcagtgt gccgctggga taccgacctg
    11881 cccaactggc acactccggc ttggagtatc gcaccgaaaa ccccgatggc agagtccttc
    11941 cccggtggcg tgctgaactg cggtctcgcc cacggtgtgc cggggccgtt ggcgctactg
    12001 tcgctggccg agctgtccgg catttccgtg cccgggcagg gggaagcgat cgcggtcgtc
    12061 gggcattggc tggccgcgca ccgcgccgac gacgcgcacg ggcccaactg gccgaccggt
    12121 atcccgctgc cgggtaccgc cgcggtcgag acgcgatcgc gcaatgcctg gtgttacggc
    12181 ggaccgggcg tcgcacgcgc actctggctg gcgggcaacg cgatcgatga caccgagctg
    12241 cggtcgctcg cggtcgaggc catgctcgcg gcatcgagcc ggttcgcggc gacagccgag
    12301 acggacccgg cacccggact ctgtcacggc gtcgcgggtc tgctccagat catgttgcgc
    12361 ttcgcacacg acacgggcga tccgcgattc gcccgtgccg cagtggaact gaccgaccgg
    12421 ttgctcgcgc ggtacgaccc ggcgcaccgg ttcggcttcc gctgtgccgg cgagctgccc
    12481 gcggatcggc ccggcctgct cgacggcgcc gcggggatcg cgctcgccct gctcgcggcg
    12541 agtaccggcg aaatgccgga ctgggatcga atgctgttgc tggcgtgagg agatgagatg
    12601 gcgacgaccg gctcgaacct gtaccggcca ttggactggc tggtggtccg taccccgctg
    12661 ctgcccctcg gggagtacct ggcgctcggt gccgatccgg ccgccgactg gcctgcccgc
    12721 accgcccccg gcacgctggt gcccgccgat ccccgggtcc agcggtcgct cgcggtgggc
    12781 ggcggggagc tgctgcgggc cttggaacgt ccgtgcgccg acgttcgcgc gcggcagcgc
    12841 ctggccggga agctccagcg gtatctgatc cggatgtcca gtcggcccac ccccttcggc
    12901 atgttcgccg gagtcggtct cgcgggctgg ggtccggcta ccgacctcga gctcgccgac
    12961 gcacccgccg tgctgcggac caggccggac atgggctggc tgctcgactt cgtgcagacg
    13021 ctggagcaac gcgacgagat ccgggcgcag ctgcgcctgt gcagcaatcc cgctgcgttc
    13081 gtgcaggcgg atcgggtgtt tctcagcgag cgcaccccga tcggagaggc cgccgaatcg
    13141 gggcgtgcga tgtcgttgcg cgccaccacg ccggtacgcc gggcgctgga acgcgcgcgg
    13201 accccgacgc gctaccgcga tctcgtggac gaactggccg cggaactcgg cgcgagcgcc
    13261 gaccgggtgc gcggtctgct ggaccagctg tgcgaacaga ccctcttgct caccgacctg
    13321 cggccgccgg tcaccgccgc cgatccggcg ggctatgttg cccgccgcct cgcggagatt
    13381 cccgccgcgg gtccggccgc ggccgccctc ggcgagctgc tcgaacaact cggcgactgg
    13441 gatcggctcg accacgatca ggccgccgcc gggtacccga aactactgga tcgggcgcac
    13501 tcggtgcatg cggtggcgac gccgaaagga ccgttccaaa ccgacatgag cagaccgttc
    13561 accgggcgac aggtgcacgc ggcggtcgcg accgaagctg tccgtgcggc cgaactgacc
    13621 atccggctga gttcctggcc ggccggaaca gccgaattgg acagttaccg agcggctttc
    13681 accgaacggt acggtccgga ccgggaggtg gggctgctcg aactgctgga cccggagatc
    13741 ggactcggcg caccgcgcaa ggccgacaag ggcggggccg acgacgagcg acggcaggtg
    13801 cgccaccgca cgctgaccga tctggcgctc gacgcgatca gagagcgcaa gtccgtcgtc
    13861 gaactcgacg ccgcgaccat cgcgaaactc gaactgcagt cggccgagct gacgaaagcg
    13921 cccgcctcgc tcgacatttc gctgttcgtg gtcgcggatt cggcggcggc ggtggacgcg
    13981 ggcgagttcc aggtggtggt cggacccaac ctcggggcct cgacagcggg ccgggtgctg
    14041 ggccgcttcg ccgatctgat cggaccgtcg gccgaacagg cgttgcacga ggcggcggca
    14101 gcggaggcgc agtgccggcc cgggcggctg tgggccgagg tcagctatct gccgcgaccc
    14161 ggccggctgg cgaatgtcac gatccgcccg ctggcccgcg cgtgggagtt gcccttcgac
    14221 accacgcccg gcgcgccggc ggagcgggtg attccgttgt ccgagttggt ggtcggactg
    14281 cggaacggcc gcttcgtggt gcgttggcca cgcaccgggc aggaggtcgt cacctgtgcc
    14341 gggcacatgc tcaacgccca ggtggcgccc gcggtggtgc ggttcctcga cgagatcaac
    14401 cgggacggca ggccggtgcc gatgaccttc gattggggcc cggcgaccgg tttcccgttc
    14461 ctgccgcggg tgcaggccgg ccgggtcgtg ctggcgccgg cgcggtggcg cgtgcccgcc
    14521 gacgacctgg cgccgaaggc ggcggcctcg ttcgcggctg ccttcgccgc gtggcggcag
    14581 cgctggcagc cgccgcgtca tctgtatctc gcgatggccg accatcgcct gctgctcgac
    14641 ctggacgccc cggatcaggt cgagcagatc cgagacgagg cgcggcgcac gcccggcggc
    14701 aagctgtatc tggaggaggc attacccggg cccgggcacg cgtggctgcc cggccccgac
    14761 ggccactacc tcagtgagct ggtggtgccg ctggtacgta ccgccgtcga gcccgaaccc
    14821 gttcgcgggc aggcgcgttc ggtgccgccg accacctcgg tggcgcggtt gcggccgccg
    14881 ggcagcgatt ggctgttcgc caagctctat cacgtaccga cgttcgagga ggatctgctc
    14941 gcgcatcaga tccgggactt ctgcgcgcag gccgtcgcgg acggttcggc cgacaactgg
    15001 ttcttcctgc gctataccga tcccgacccg cacctgcgga ttcgctggca cggcgacccg
    15061 gaccggctga ccgatcgcct ggcacccgcg ctgttgcgct gggggtcgcg attggtcacc
    15121 gacgggtact gccgcagagt atcggtggac acctacgacc aggaggtgga acgctacggc
    15181 ggtccggcgg ggaccgcggt ggccgaggac ctgttcgccg ccgacagcgc ggcggtgctg
    15241 gagctgctcg cgctggtcga tcggcgcatc gtcacgctgg accgcaggct gctggcgatg
    15301 gtcacggtgg acgacctggt caccgcgttc ggcctgaccc aggccgagca gatcgacctg
    15361 taccggaacg gcgtgctcga gcggcgcgcc accgcggacg aataccgcag ggagaatgcg
    15421 acattcaggt cactgctcgg cgatcggcgt tggctggcga gtcagcccgg gggttccgct
    15481 gtcgcggaga tcttgaatcg tcgccgaatt ctcttgcagg cggcggcatc ccggctcgac
    15541 ctgctcgcga accggggcga actcaccagg tcgcggccgg aactggtgcg cagcttcgtg
    15601 cacatgcact gcaacaggct gctcggctgc gggcatccgc cggagcagcg ggtgctcgga
    15661 ttgctgtggc gcaccaggga aagcctgcgg cacgcaccgg tcgcgctcag ctgagcgcga
    15721 ccccgaagcc ggcctcccgc gcgcgcagga tcgcgttcgc gcgatcgcat actccgagct
    15781 tgaggaagat cgccgaaagg tagttgctca ccgtcttgga ggccagatgc agccgtcccg
    15841 cgatcgccgc gttggacagg cccgccgcga ccagttcgag cacctcgcgt tcgcggacgg
    15901 tgaggtcggc gaacgcgacg acctccaccg tggccggctg ggcggtgatc cgcgccagcg
    15961 cctcggcact gcccgggctg aacaccgccc atccggcggc cgcgccggcc accgcccgga
    16021 cgatgccttc cgcggtgctg gacttgtcga catagccgcg tgcgcccgcg ttgatcgcgg
    16081 cgcgcacggc gccgtcgtcc tcgtccatcc cgaacaccag caccgccagt cccggacagg
    16141 agcgcaggat atcggtgatc acccggtggg tccgctcctg cgacaacagc aggccgagca
    16201 ccacgacgtc cggtcgctcc cgcagcgcct gccgggtcag ttcgctgacc gtcgccgcct
    16261 ccccgacaat ggtgaattcg gcaaccgcgg ccagcatcga gcgcagacca gcacgcacca
    16321 cggcgtgctg gtcggccagc accacggtga tctgcggaac cggtgcttcg gtcaccgagt
    16381 cgtcctgcgc cacatgccat ccggcgctct gcgccgaccg gagccgccgg tgaccattgc
    16441 tcgtgttcac gtcacccccg gacgggttcg aacgtcggat gtctcaactg actgagaatg
    16501 gccgacgcca ccgcgcaggg gaagatctcg gaccgctggt cgaacctcgt cgcgtcgatc
    16561 cgacggcggt gcggcgctca ggtcagaact ttgacgcccc ggaccgcccg tagttcaccg
    16621 agcagcgccg ggctgacggt gaccgggtag tcctcgatcg ccagcatggt ccgccgctgc
    16681 cggtagcaca gcgcgaggtg caccggcgtg ccaccgggat gggccagcag caccgacttc
    16741 aattcccgca tgctgtcgcg atcggtgttg cgggcgttga tctccagcgt caggggtgcc
    16801 tgccgccggt gctcgtccaa gtgggtcagg tccagcgcgg ccaggtgtgc gccgaacagc
    16861 gccagtttgt cctcgcgcca gttcaccctt ccttcgacga ccaccaccgc gtccaccatc
    16921 agatccgccg cgaacaggct gtagctcttc gggaagaaca gcacctcgac ggtggcgtcg
    16981 aggtcttcta tcaccgcgat cgcccagctc tcgcccttct tgttgacgcg tcgctccagt
    17041 gccgagatca tgccagcgat ggtgacggtt ccgtcccgcg gcgggttggc gagcagcgcc
    17101 gcgatcggct tcggggcgtg cttgcgcaac aggtgatcgg caccgtcgag cgggtggccc
    17161 gagacataca ggcccagcat ttcgcgttcc agcccgagca attcgtcgcg cggccattcc
    17221 ggcgcgtcga agctcagatg tgctagggga gaggatgatt cggctgctgc gtcgccgtcg
    17281 ccgaacagat cgaactggcc catcgcctgt tggcgcttca gtccggtgac ggcatccacc
    17341 gcgtcctcgt gaatatcggc gagcgccctg cgcgggtgac cgaacgaatc gaacgcaccc
    17401 gccttgatca gcgattccag cacgcgtttg ttgcagcaga ccagttcgga cttctcgacg
    17461 aaatccgcga acgacgcgta tttccctttc cgcgtgcggg tttcgatgat cgactcgacc
    17521 acattggcgc ccacgttgcg cacgccgccg agcccgaacc ggatgtcggt gccgaccgcg
    17581 gcgaaccgca gcgaggactc gttgacgtcc ggcgccagca ccttgatgcc gagctggcgg
    17641 cactcggaca gatagattgc cgacttgtct ttgttgtcgg cgaccgaagt cagcagtgcc
    17701 gccatgtatt cggcgggata gttggctttg agataggccg tccagtagcc gaccagtgcg
    17761 tagcctgccg cgtgcgattt gttgaacgcg tatccggcga acgggagcac ggtatcccac
    17821 agggcctgca ccgcctcgtc ggagaagccg ttgtcccgca tgcccgctcg gaagccctcg
    17881 aactccttct ccagcacgtc gagtttcttc ttgcccatcg cccggcgcag cacgtccgcg
    17941 cggcccatcg agaacccggc gacccgctgc gcgatctgca tgatctgctc ctgatacacg
    18001 accaggccat aggtttcggc gaggatgtcg cgcagcggct cggcgagttc ggcatgaatc
    18061 ggcacgatct gttgccggtc gttcttgcgg tcggcgtagt tgttgtgcgt gttcatcgcc
    18121 atcggtcccg gccgatacag cgcgttgacc gcgacgatgt cctcgaatcc ggtggggatc
    18181 agccgccgga gcagatcgcg catcgcggcg ccgtcgagct ggaacacccc caggctctcg
    18241 ccacggccca gcagcgcata ggttttcgcg tcgtcggtgc cgagcgtgtc gagatcgacc
    18301 gtctcgccgc gattggcccg gatgttgtcg atcgcgtcgc cgatcacggt gagattgcgc
    18361 aggcccagga agtccatctt gagcagcccg acggcctcgc aggacggata gtcccagccg
    18421 gtgatcatcg cgccgtcttc gcgccgccac agcggcacca cgtgcagcag cggctccgcg
    18481 gacatgatca ccgcgcaggc gtgcacgccg gcattgcgga tcagcccttc gaggccgcgc
    18541 gcggtatcca tgatggtggc gacgtcgcga tcggtgtcga gcagcgcgcg cacctccgcc
    18601 gcttccgggt agcgctcgtg cgcgggatcg gtgataccgg acagcggaat atctttggcc
    18661 gcgaccggcg gcggcagggc cttggaaatg cggtccgcga tcgcgaaacc ggcctggccg
    18721 tagtgcacgc gggccgaatc cttgatggcc gctttggttt tgatcttgcc gaaggtgatc
    18781 acctgggcga cgcggtcggc cccgtacttc tcggtcgcgt agcgcaccat ctcgccgcgc
    18841 cggcgatcgt cgaagtccat gtcgatatcg ggcatggaca tgcgttcggg attcaggaag
    18901 cgttcgaaca gcagcccgtg cacgatcgga tcgaggttgg tgatgcccat cgcgtacgcc
    18961 accagcgatc cggccgccga gccacgtccc ggcccgaccc gaatgccttc ggcgcgtgcg
    19021 tgttccatca gatctgcggt gatcaggaaa tacgcgggaa agcccttctc gacgatgatg
    19081 ccgatctcga actccgcccg gtgccggtac tcgtcggtga ccccgccagg gagcggccgg
    19141 gcgagaccgc gcatgacctc cgcgtggaac cacgagttca cgtcatggcc tggcggcggt
    19201 gcgtagaccg gcatccggtc ccggtgttgc cacacgtcgg cataggattc gacccgctcg
    19261 gcgatcgcga cggtgttgtc cgccgcgccc ggcacctgcg cgtcccagta ggcgcgcatc
    19321 tcttcggccg aacgcaggtg gtagccgtcg ccgtcgaatt tgaaccgggt cgggtcgttc
    19381 agggtcttcc cggcttgtac gcagagcagc gcggcgtgcg cctcggcttg atccttgcgc
    19441 acgtagtgcg aatcgttggt ggccagcggc ggcaggtcga gtttgcggct gatctccagc
    19501 agcccgtcgc gcaccgatcg ctcgatgggc aggccgtgat ccatcaactc cacgaaaaag
    19561 ctttctctgc cgaagatgtc gcgatagtcg gcggcggcct gcatcgcctc cgcgtgctgt
    19621 cccaggcgca ggcgggtctg cacctcgccc gaggggcacc cggtggtggc gatgatcccg
    19681 gcggcgtgcc gggcgatcag ctcccggtcc atccgcggtt tgcggtagta gccctccata
    19741 ctcgccagcg aggacaacgc gaacagattg cgcaggccct gcgcggtgcg cgcgagcatc
    19801 gtcatgtggg tgtacgcgcc gccgcccgag acatcgccgc cgatgccctc accgttggcg
    19861 ccgcgctgac ccgactggcc ccagaacacg ggcttcttgt gcagcctgct gccgggcgcg
    19921 acatacgcct cgatgccgat gaccggtttg atgccgactt tcgtggcgtg ctggtagaac
    19981 tcgtccgcgc cgaacatgtt gccgtggtcg gtcatgccca ccgcggtcat gcccaggcgg
    20041 gccgcttcgt caaacagcgg cttgatcttc gccgcgccgt cgagcatcga gtactcggtg
    20101 tgcacgtgca ggtgaacgaa cgaagacaac agacgccctc caaggctgcg acccgggttc
    20161 ggatcgccct attcgagccg agggggtgcg gggcgtcaaa caatcgacag gcgttggggg
    20221 acaaccatca gttgttgtcc cagcgtccgc cgccggcttc ggcgggcggc agccactggg
    20281 ttcgcggatc gaaggggcgg aacccggccg cgacgtagcc ggcgagctgc cgcagcgcgg
    20341 ggcgctggtt gtcgcgatgc cacagcatcg aatgggggta gccgggtgcg ggatcgacga
    20401 ccggaagctg cacgatctcc ggatgccaag gggcgcgcag acgttcgccg gtgaacacgt
    20461 aactgtccga cgtgcgggcg aggtcgtcga gcagatgatc caagccgaag tccgggccgg
    20521 tggtatcgat ggcgagcccg aaagccgcgg cgagatcgtc gtagaaccgg gcccattcgc
    20581 tgcccggcac gttgctcggc atccgggcga tcgaatccgc cagctcgcgc aggcggacct
    20641 gacgacggtt cgcgagcggg tgtttgcggc cgacgaggat gtgcagaggt tcgaaatagg
    20701 cgggaatatg ggtgatcacg gtgtcgagcg gcccgatcgc gcgggcgaac gcgacatcga
    20761 tcgtgccggc gacgagggcg ggtagtccgc tgcgcagccc gctggaggtg atgatgtcga
    20821 tctcgaaatc ggggtgggcc gtatgaaacg ctctgatcaa ttccgttgcc gcgagccggg
    20881 ttccgagcac gtccacgcgc agcgggcgct cccgttcgcg caccgcggcg gtggcttggt
    20941 cggcgagcgc gagcagggcc cgagcctggg gcaggaaggc cgcgccgatc tcggtcaggc
    21001 cggttccggt gcgggtgcgt tgcagcagtg tggcgcccag ccccgcttcg agtttcgcga
    21061 tgcgcttgga gatcgcctgc tgggtcagct tcagttggtc cgccgcgtcg ccgaaatgct
    21121 ggtgatcggc gatcgcgagg aaggcgcgca ccgcaccgcg atccaattcc acccggccgt
    21181 cctttcacaa ctgtcagttg tcgacagcga gcacggtacg gtattcggcg gcagcggctc
    21241 tcaatacccg cgccagaccg gtgtgcgctt ctcgagaaac gcgtgcatgc cctcctgcgc
    21301 gtcgcaggtc atggcattgg tcgccatcac ctcgcccatc tgctcgtagg cctggggttg
    21361 cggcaagtcg atctggtggt agaaggcttg tttcccgatg cgcagcgtcg aggggctggc
    21421 ctgcgcgatc gactcggcga gttcgtgggt gcgcgcggcc agggcgtcgg cggggaccac
    21481 atcgttgatc agcccccagt ccgcggcggt cggcgcgtcg atcacggcac cggtcagcag
    21541 cagttgcatc gcacgtttgc ggccgatggc ccggctcacc gcgaccatcg gcgtcgagca
    21601 gaacaggccg atccgcaccc cgggcgtccc gaaaacggcg tcgggagtgg cgagggcgag
    21661 gtcgcaggtg gcgacgagct gacatcccgc ggcgacggcg ggcccttgca cggacgcgag
    21721 caccggctgc gggatctgct ggatcgtctg catcaattcg atacaggcgg cgaagagggc
    21781 gcgttcgtcg tcgagcgaac ggtccaccag ttccccgaga tcgtgaccgg cgcagaaggc
    21841 acggcccgcc gcccggatca ccaccacggc gacctcgcta ttgccgccga attcccgcaa
    21901 cgcggcagtg agctcggcca tcatgttggc ggacaacggg ttccgctgat cggggcggtt
    21961 cagcgtgaga tacccgatcc gagctcgctg ctcggtgacg acgtagctgc tcatatcgga
    22021 atgtctacca gtcgggtggt ccgtcggcgg cgctttcgcg gtggcggtcc aggcctggag
    22081 cgaggcgctg cgccggcggc gccgcccggt tcgaacacgc cgacaaccgg ggggctccgt
    22141 tccggccgcc gatcttgcac aatcggtgca tgcccaagcc ttttctgctg ctgcaactgc
    22201 ggcccgagcg cgccgccgcg gacgacgagt accacgccat cctgcgggcc ggcgaactcg
    22261 acgccggcga cgtggtgcgc gtgcggatgg aggagggctt ccccgatctc accctcgacg
    22321 actacgccgc ggtcatcgtc ggcggtggac ccagcaatgt cggcaatgcc gacgtcgaaa
    22381 agtacgacta tcaacggcgc ttcgagcccg cgttgaaaaa gttgctcacc gagatcgtca
    22441 gtcgtgactt cccctacctc ggggcctgct acgggctcag cgtgctcgcg gatgtgctgg
    22501 gcggcacggt cagcaccgag aactacggcg agaccgcggg cgcgcagacc atcgaactga
    22561 ccgacgacgc ccgcgaagac ccactgctcc aaggtattcc gcgaaacttc cgggccttcg
    22621 tcggccacaa ggaggcgtgc caggcggtgc cgcccgaggc ggtcctgctc gccggttccg
    22681 ccgactgtcc ggtccagatg atccgcgtcg ctcgcaatat ctacgccacc cagttccacc
    22741 ccgaactgga tggcgacggt cttgccctcc gcatcgagat ataccgccac gcaggctatt
    22801 tcgacccgga cgaggccgac tacctcaccc gtctcggcca ccaggaatcc atcaccgcac
    22861 ccaaacagat cctgcgccgc ttcgtcctgc gatacggcgg tgcggcgacc tgatcgcgag
    22921 agctattcgg ttgctgtgcg tcgctcgtag cgggaccgtg cgcggtcgta ggcggcgcgg
    22981 aggaaccggc gggccgaatc gctggttcgg acagcgggat cgacgacgga gatccaggcc
    23041 gcggcggcgt aggtggggtg tgggaggaag acgtcggtgc tgctgtagtc gaggtcggcg
    23101 ggcacctcgc ggggcgggta gccgagggtt tcgatgaagg tgtccttacc ggcggagatg
    23161 ttgaggcgga aggcgtccgg gcggttcaga cgagagtgtt gatcgtcggg atagtccttg
    23221 gtgacgatgg tggcgaacgg ctgggtgttg gtcgggacga cgccgtcggg ggagtagtag
    23281 aagaacttgt cgccccaggc gatctccggg gtgccgtcgc ccggagccgg cgccagaacg
    23341 aggatgccgt cgaggtcggt gagcaggtcg atgatctcgt ctatcgtcat aggttcgagc
    23401 gtctcattca agtgcttgtg tggacctggg gcccaagtac gaggagttct gcgtgaaaaa
    23461 cctcaactcg caggtcatgc gcaccgtcga tgtcgcccga cgggcggggt actcggtgca
    23521 gcagatccgc aatctcgaac gcgacggggt gctgccgccg gccgaacgaa ccccgacggg
    23581 acatcgggtc tatcgcgagg tgcatctgca cgccgcgctc gcctatcgtg cgctcgccgc
    23641 gggcgcgggt ccggtggcgg ccaaacagat cctccgtact gtgcacaccg gctccattgc
    23701 cgaagcactc gctctgctcg acgccgcaca cgcccggctg cacgtcgaac gcgtcgaact
    23761 cgcgcacgcc aaggcggccg cagacgccat cgccgccgaa ccgattgcgg ccgtgcggga
    23821 ttccgactcg atgacggtgt ccgagctggc cggtgcgctg ggtgtccgca cgtcgacgct
    23881 gcggcattgg gacgcagcag gtctcgtcgt ccccgatcgt gaccgaaccg cgcgccgcta
    23941 caccccgagt caggttcgtg acgcgcgcat cgttcatcag cttcggcggg cgggctaccg
    24001 aattccacag ttacgcaatg tgcttccgga gttgcggcgg gtccacgacg cctccgacgt
    24061 gcatgctgcg ctcgccgccc gggatgctgt gctcgcgtct cgttcccgcg ccctgctcgc
    24121 tgcggctgcc tccctgcatt tgctcgttgt cgaggtctga gggtgggttg tgggcgagtt
    24181 cggttggggg ttcttgcgtt tgggcttgtt ggctggctgc cgatgtgtga cttgcccagt
    24241 gtggtgtgcc tgccgcggga gttacatgga tggtgctggg cgcgtcgtgt gccgtacccg
    24301 gctgtgggtg caggtcaggt gcgcggtgtc gtgttccggc gtggtcgtct ggctgtggtg
    24361 gcgtctcgag cggcttggga gaagggggtg ggtgggaagc ggcatggtgg gtgtgggccg
    24421 agcggcgtgg cggtggtgaa tccgcccggc gagtccggag acttattgct gtggcagctc
    24481 ggcgggttgc cgggctggtt gttgagcgta gtaggcggtc tccatctcgg cgggcggtat
    24541 atcaccgcag tgctggtaga ggcgtcgatg gttgaaccag tccacccatt cggcggtggc
    24601 gagctcgacc tgatcgacgg tgcgccacgg ggctcggggt ttgatcaact cggttttgaa
    24661 caacccgttg atcgtctcgg ccagagcgtt gtcataggag gagccgaccg ctccgaccga
    24721 gggctggata ccggcctcgg cgaggcgctc ggcgaacgct atcgatgtgt attgagaccc
    24781 atgatcatta tggtggacaa catctttgat gtcccagccc tgtcgttcac gggtccagat
    24841 cgcgtgctcg atcgcatcga gtaccagcgc ggtggtcatc gacgtggcag tgcgccagcc
    24901 gatgacccgc cgagcatagg catcgatcac gaacgcgaca tacacccacc cagaccaggt
    24961 ccggacatag gtgatgtcag ccacccacaa ccggttcggt gccgtcgggg cgaacctgcg
    25021 ccgcaccaga tcggccggcc ggaccgcggc cgggtcagcg atcgtggtgc gtgtgacccg
    25081 gccgcgcacc gcgccacgta acccggcagt gcgcatcagc cgttccacag tgcagcgagc
    25141 caccgcgatc ccttcccgat tcagttgcag ccacaccttt ctcgcgccat acacaccgaa
    25201 gttctccgca tgcacacgcc cgatttcggc gatcagttcc tgatcccgat tctcccgcac
    25261 tgtcggcatt cgatcgcggt gctcgtaata agtcgacggg gcgatcttca caccgagctc
    25321 ggcgagtgca gcacagatcg actcgacacc ccatcgcagg ccaccctcga cacgacggcc
    25381 ctgatgctcg ctgatgtatc tgaccgtcag cgctgtggcc ggtccagttc ggccgcgaag
    25441 aaagccgacg ccgatttcag aatcgcgttg gcacgcttga gttctgcatt ctcccgccgc
    25501 aaccgtctca gctcgtcgga ctcatcgctg gtgacacccg gacgagcacc ggtatcgatc
    25561 tgagcttgcc gcacccactt acgcaccgtt tccggcgtcc ccacccccaa caactcagcc
    25621 accgcaccca tcgccgccca ctccgactcg tgctgctccc gaatctcggc atacatccgc
    25681 acagcccgct cacgcaactc gaccggatac ctct
//
