LOCUS       NC_018681              24490 bp    DNA     circular CON 21-MAR-2024
DEFINITION  Nocardia brasiliensis ATCC 700358, complete sequence.
ACCESSION   NC_018681
VERSION     NC_018681.1
KEYWORDS    RefSeq.
SOURCE      Nocardia brasiliensis ATCC 700358
  ORGANISM  Nocardia brasiliensis ATCC 700358
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Complete genome sequence of Nocardia brasiliensis HUJEG-1
  JOURNAL   J Bacteriol 194 (10), 2761-2762 (2012)
   PUBMED   22535940
REFERENCE   2  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-SEP-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
REFERENCE   3  (bases 1 to 9436348)
  AUTHORS   Vera-Cabrera,L., Ortiz-Lopez,R., Elizondo-Gonzalez,R.,
            Perez-Maya,A.A. and Ocampo-Candiani,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2012) Servicio de Dermatologia,Hospital
            Universitario 'Dr. Jose E. Gonzalez' and Centro de Investigacion y
            Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo
            Leon, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, Nuevo Leon
            64460, Mexico
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000250675.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 01:53:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,551
            CDSs (total)                      :: 8,489
            Genes (coding)                    :: 8,417
            CDSs (with protein)               :: 8,417
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 13 of 72
            Pseudo Genes (incomplete)         :: 63 of 72
            Pseudo Genes (internal stop)      :: 3 of 72
            Pseudo Genes (multiple problems)  :: 6 of 72
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:09:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1298271
            Orig. end                         :: 1322761
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003876.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24490
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24490
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24490
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14490](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14490)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    1374..1388
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            complement(3412..3711)
                     /locus_tag="O3I_RS05660"
                     /old_locus_tag="O3I_005595"
     CDS             complement(3412..3711)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005595"
                     /product="hypothetical protein"
                     /protein_id="WP_014981937.1"
                     /transl_table=11
                     /translation="MPLLTPDPVRSDAAVAGPAPDPAPLAPLPAPRGRTLGRRRTWHGF
                     GVSVLALVITAGVVALCLALPAQAPLVVAVLGILTLTPPATLAVTVCRHRRPNT"
     gene            4117..4875
                     /locus_tag="O3I_RS05665"
                     /old_locus_tag="O3I_005600"
     CDS             4117..4875
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005600"
                     /product="hypothetical protein"
                     /protein_id="WP_014981938.1"
                     /transl_table=11
                     /translation="MNALQLSQGIEATATTTAFAHPSLRDYLDPADGRWAGLFAAPLRL
                     EFAEYDELGVRHDTEGAPIVLPVHTECQAEQLRSIRARHAMTLLVAVTNDVTGHSTYLA
                     IRAGANFVINLAISIERQAEVLRARLLDHVSAQPRRPRPPVLGAVPDRATAAREPRPAR
                     DAVPAAPNGLRAATPINRPELDEFDARLLRMLKTSMTVAEIARQNYLSERSMYRRIRNL
                     YDVLGVSGRNDLVNSGAHDHPRAPLTVLRG"
     gene            4950..5207
                     /locus_tag="O3I_RS05670"
                     /old_locus_tag="O3I_005605"
     CDS             4950..5207
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021560.4"
                     /locus_tag="O3I_RS05670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005605"
                     /product="DUF2283 domain-containing protein"
                     /protein_id="WP_014981939.1"
                     /transl_table=11
                     /translation="MNPDLIDYVTWDDQHNVAYLALRQNTAGPRYAARTLPVQDSTDNE
                     VVAALDFGADGELIGIELLRADSQLSAALKAKARTASETE"
     gene            5281..6090
                     /locus_tag="O3I_RS05675"
                     /old_locus_tag="O3I_005610"
     CDS             5281..6090
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="O3I_RS05675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005610"
                     /product="ABC transporter permease"
                     /protein_id="WP_014981940.1"
                     /transl_table=11
                     /translation="MATTAPHQGLEIRPRRDQPSLWHVTATELSRMRRGFIGWFVILVP
                     IVLTVPLYPMSLASPEGKSGHAWMVFRDVTLEGWGVLIPMTAALLAALSVRADQDAWRL
                     LFSYAVPRTKYLLGKYFALAALSAVSTTLLAALLCVGAALGGRLGSSIGTIVAASFLPW
                     LAGLGCAAVALVVSMVWGLGPTIAIGVVGMMSGMLIADKTWWMAVPFAWPMRVILPLAG
                     IGPNGVPLPADSPVRDHGVILPAIALSFGLAAVVLALGSAHLERKEI"
     gene            6093..6803
                     /locus_tag="O3I_RS05680"
                     /old_locus_tag="O3I_005615"
     CDS             6093..6803
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="O3I_RS05680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005615"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_014981941.1"
                     /transl_table=11
                     /translation="MSALEVSQLHKHYGKHRALDGVELSVRTGEVYGLLGPNGAGKSTL
                     MKTVLGLQRPTSGHIQLFGRPYHRAQLVDVGALIETPGLWPKLDALTHLRIHAKLRGVP
                     EAWIDEALAVVQLNDVRDRKIQAFSLGMRWRLGIAIALLARPKLLLLDEPTNGLDPVGI
                     REMRGIIRSLAANGTTVFISSHQLSEIAQVCDRVAVLVAGKTRYEGTLEGIAGDGDLEA
                     GFFRILESCDSRIR"
     misc_feature    6516..6518
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6818..7027
                     /locus_tag="O3I_RS05685"
                     /old_locus_tag="O3I_005620"
     CDS             6818..7027
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005620"
                     /product="hypothetical protein"
                     /protein_id="WP_014981942.1"
                     /transl_table=11
                     /translation="MPSKGDPNSRFGSPGILARKAEAAVGLLLGKQETCRAQRKGTFGQ
                     PEFGAAAQQRGERFEVVAPNRQHQ"
     gene            complement(7272..8267)
                     /locus_tag="O3I_RS05690"
                     /old_locus_tag="O3I_005625"
     CDS             complement(7272..8267)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005625"
                     /product="hypothetical protein"
                     /protein_id="WP_014981943.1"
                     /transl_table=11
                     /translation="MTPMAGRYLDAGLRGQVTGYPVWPPPSRIEYRGDGPILDEAVAWL
                     HANLRWFDPDRWERMLPPRPFREGAALELLMLCRILRRGRFHDHPLIEGAVELAHSLAA
                     TDSFHAALGLGDDKFPYRTYLVALLADLGRPVPSAAERVRTVLATGCGGQHGAWRTPLS
                     RLELHYVLELGQFPNPLPPIAELLELSIVAAAPDPLYLRDDEVYALTHVLFYATDFAAR
                     ATPAEPELVEALRTLLGTYLALGDMDLAGELLLCLLAIGQPDCALTTHGWHTLARHRLS
                     DGAVPGPLFDPARWSTLRGEVAEGYSFGTCHHTTMVAAMAAAERERHGAR"
     gene            complement(8264..9061)
                     /locus_tag="O3I_RS05695"
                     /old_locus_tag="O3I_005630"
     CDS             complement(8264..9061)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="O3I_RS05695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005630"
                     /product="ABC transporter permease"
                     /protein_id="WP_167829102.1"
                     /transl_table=11
                     /translation="MTTMHPTAAPAREHAMVSGVRAIAVIAGRDLQRQLRRPGLLLSNA
                     AQLLFFIAIYAVGFDAMVGTVDSVSFSAYILPGIIAIQVATIGIATGLSYAWDREFGVL
                     REMTVAPVPRMCLPLGKVASTGVIVGIQSLLLLSCAPVFGLTPTMGQIAVAMLIYLFGS
                     AVFSLLGLFLATAFRQIQTLQASVQMMMLPMLFLSGSVFQPEVVPTWLSVLIRINPLTY
                     LVDLGRHVLVGAERGLVPAGVDVLVLAALAVFFAVAIRLRIGQ"
     gene            complement(9058..9984)
                     /locus_tag="O3I_RS05700"
                     /old_locus_tag="O3I_005635"
     CDS             complement(9058..9984)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="O3I_RS05700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005635"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_014981945.1"
                     /transl_table=11
                     /translation="MAVNAFELSDIVVRYGSTLAVDSVSLRSVPGKLTALLGPNGAGKS
                     SLLNVLSTAARPASGTVRIFGSDVRTAPMRARAQLGLVFQERTLDKELTVEQNLWFHAR
                     LFGMRRADTAAQIDRLLDLLELTAQRRTAVERLSGGTARRVELVRALLHRPGLLILDEP
                     TTGLDPRSRRVVWRDLLRMRDELGVTTLYSTHYLDEAEYADEIVIMSDGRIGRSGSPVE
                     LKDELRVSCVRLRTHDDEAAAAQLRTAGFEVVTGFTELEVRCTDPDRRVADIVRVLELP
                     ISSVTVHNPSMDDVYVAATARAGKGIS"
     misc_feature    complement(9304..9306)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..11377)
                     /locus_tag="O3I_RS05705"
                     /old_locus_tag="O3I_005640"
     CDS             complement(10001..11377)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="O3I_RS05705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005640"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_014981946.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-50, bitscore:
                     171.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTALPQQVSPAERAAELVTLVAERLADPAAVATIADRPDNHDPI
                     YGSVMWGPMTLSTGLPGTAMFYAELARRTPSWSSTTHDHVRAAGETMSSQPSRGLYAGP
                     AALLAAAQTCEGHYPGLRRKLAAWLADDQLTRLRRLRAQPGPGISWECYDIVNGLSGTA
                     RILLDSLDDPVENGAEVRRALYDTLQYLVQISEPITVDGHVVPGWWVPAARQAVEQDRL
                     DYPRGDFNLGLAHGIPGPVSVLSTALRRGHEVPGQRAALKRMVQWLIRWLRTDDQGSYW
                     PCRIPFDDEIATTATEDLFTRTAWCYGAPGVAAAVHHAGQTLDIPEWRTHAVQALHDAL
                     ARDESRWTLAGPTICHGYAGLLQVVHRIGTAEQDDVLLAAKHRLAATILDMADPAAPFV
                     FRQPMRYPRSAPGPSEFKLLDIAGLLEGAAGVACALLSVLPDSSAETARHPWDRVLALS
                     "
     gene            complement(11374..14490)
                     /locus_tag="O3I_RS05710"
                     /old_locus_tag="O3I_005645"
     CDS             complement(11374..14490)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="O3I_RS05710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005645"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_014981947.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-183, bitscore:
                     611.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.6e-11,
                     bitscore: 41.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.4e-32, bitscore:
                     110.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDSIFRAWDVFMLRAPLALGRPGIPTGGGHLGIVRAAAADSTLR
                     TAITLASPSLGNLLDRVHRGEHRGIKATQLRRAALAVLRYDIRTRMRPTPFGVFSGVTG
                     GRFDFSAKLDRGTRHRTRTHADMQWLLGVVQQLQSRPELLPGLRVLAHPALSGRGDRVV
                     LDCPSPLGAPLDGQTRAVVSLRNSPVVQAALRAAERMVSIDELTATIAARFGAPPRRVA
                     EVLRVLVEQEFLLTELRPPLDGGDPLGHVIDVLASIEDPATPIAATLRALREIDDRRRS
                     SDLLPLGPGTARLIETAAQADRLHSYDTPLHIDSAVDIDVQLPLEVRAEVERAAELMWR
                     MSADKLGLVALRDYHAKFLERYGTDRLVRVGELLDATRGMGAPAGYIWPESQETKPDPA
                     IGREPARIRLLHNLVGIALRDGLREVELTDATLNDLIGANDGDADAPNSCEITFHVIAA
                     SLDALSAGDFRIVLAPSPGSHHAGATLARFADLLPAEIRAELAAESAAIPVHVDGAMRV
                     DLSFMTRSGKAANLAHCAVHSGARISVGLPAARGTDEIPLAEVAVGATTERLCAVHLPT
                     GREIVPVLNNMISPMTQAPNAARLLWEIGLEGQRLWEPWTWAGLTELPFVPRIRHGRFV
                     LAPAVWRMDTLLGVAEPDFAAAVAAWRREWRVPERILTVQMDQRLLFDLTDPAHLELLW
                     DELRKDPGLVAHELPGDDEYSDGIDGHAMEIVVPLSRRDTRPARSPHGGRLGVERTAAG
                     LGSDWLSLELYLPVAEQSEFLRVHLPGLVERAQENGCDRWFFIRYTGPNGPHLRIRCHG
                     TAADLWGAAASSLGRRLEQWQHEGLIRTHRIEPYEAELERYGGVATMTMAERVFEADSR
                     AAIRFLELVDDPSCPHTLDTFAAVSVAALAAAYGLPESNPAQDNRRETDAAFAWLSMTG
                     ARAELPAAYRVDAQNWRRLVDPHGGWDGLRADPYGAAALDVLHARDTAVRELRAVLPDP
                     GIRHQRLVGSLMHMSCNRLFGGDSDRERAAVAIARGAVQDNFNKRRHAR"
     misc_feature    complement(12367..12369)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(13768..14019)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O3I_RS05710_Lanthipeptide_LanB_RRE.1"
                     /evalue="3.20E-13"
                     /identifier="RREFam001.1"
                     /label="O3I_RS05710"
                     /locus_tag="O3I_RS05710"
                     /protein_end="241"
                     /protein_start="157"
                     /score="41.2"
                     /tool="antismash"
                     /translation="RGDRVVLDCPSPLGAPLDGQTRAVVSLRNSPVVQAALRAAERMVS
                     IDELTATIAARFGAPPRRVAEVLRVLVEQEFLLTELRPP"
     gene            complement(14567..14743)
                     /locus_tag="O3I_RS43595"
     CDS             complement(14567..14743)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014145.4"
                     /locus_tag="O3I_RS43595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_115347074.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.5e-08, bitscore:
                     32.7, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTVTMEPVETVETVDLFDLDIRVGVGNIQGNAAINSWSYCTPGC
                     TSSGGGSGCSHCC"
     CDS_motif       complement(14642..14743)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSTVTMEPVETVETVDLFDLDIRVGVGNIQGNAA"
                     /locus_tag="O3I_RS43595_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14567..14641)
                     /prepeptide="core"
                     /locus_tag="O3I_RS43595_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="0.50"
                     /molecular_weight="2210.4"
                     /monoisotopic_mass="2208.8"
                     /core_sequence="INSWSYCTPGCTSSGGGSGCSHCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTVTMEPVETVETVDLFDLDIRVGVGNIQGNAA"
                     /leader_location="[14641:14743](-)"
                     /alternative_weights="2228.4"
                     /alternative_weights="2246.4"
                     /alternative_weights="2264.5"
     gene            14989..15558
                     /locus_tag="O3I_RS05715"
                     /old_locus_tag="O3I_005650"
     CDS             14989..15558
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="O3I_RS05715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005650"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_014981948.1"
                     /transl_table=11
                     /translation="MDSDEALLAAVAKGDQACLRVLYDRHAPAMLRVVRRMTAQSGVAE
                     EILQETWLAVWRSADSFRGESSARGWLFGVAKRQAHNYLRKSVLTTVDLDETPELSDHA
                     GTVEDIVLANAARGDLAAGIRDLPEHLRDVLLLVLVDDLSYPDVATVLDIPVGTVKSRM
                     SHARKRLAQTLSGTTADLSIRYGGEQ"
     gene            15555..16454
                     /locus_tag="O3I_RS05720"
                     /old_locus_tag="O3I_005655"
     CDS             15555..16454
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005655"
                     /product="hypothetical protein"
                     /protein_id="WP_014981949.1"
                     /transl_table=11
                     /translation="MTSPNTVGPHLSDDQLIGVPDDAARAHLRACSECQAHAQIWQQMA
                     VAARQVSADLVGTVRTPSFDTLLGDALGMPWATTNEAVRPGWRASLLLTATLARAQLRL
                     LPRALVLLSGLGFVGSVLLAVLTRHSGAAAPLFGLAVTLLFQLGTLATCIPRSDPRLEL
                     FATVPIAPAAVFACRLIVVLAADLALALLASLLASGLGASADFGAMVAGWLGPALLASA
                     VGVAGAVWRSPPVGAAAGAVMWLLGAAAAADAGPAHRVGALIAPLWSTSVLTLAVAALL
                     LVAAAAGMSRPRYRTVAG"
     gene            16451..17080
                     /locus_tag="O3I_RS05725"
                     /old_locus_tag="O3I_005660"
     CDS             16451..17080
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005660"
                     /product="hypothetical protein"
                     /protein_id="WP_014981950.1"
                     /transl_table=11
                     /translation="MNRIERLGYDTEVNPIWRYEIRRCGLGVLAPTPLAGVVIGIALVA
                     FDGAMILRTVALEVVPLTAGLVTAAVLGRERMLELHLTVRTPYPQTVVRRLVLVGASVC
                     GAVASIGALGWSAAAVAAGPLLVSTPAFALALISVATFVVVASGSAAGASAIVVTVWSA
                     KLLVLDQIMRGVWAQAAVAVTLAALFAWAAAVRVADSEAQLREVRA"
     gene            17077..17856
                     /locus_tag="O3I_RS05730"
                     /old_locus_tag="O3I_005665"
     CDS             17077..17856
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005665"
                     /product="hypothetical protein"
                     /protein_id="WP_014981951.1"
                     /transl_table=11
                     /translation="MTGRSFGALGATIRYEALLSFRHRTVWLSLLPLVALIMVLGEFPY
                     GRNRTGDIAAVGETALLINFLGSLGIAIVLADRLAGQRRPGLRELFGATPAGGLARTAG
                     LVLGPWLIASVPAAVVLVSMGGWLAITSGGPGPLGAAVIGVLTVVAPGSLLLTMVANVA
                     ALLLPSAVARVLLVPFWYWATLLTPLLPIPTPARTVWSPLGDYQAAQWLEVALPGRTGG
                     WLYPAVSVTSSILACGLTLAVTALAFLIGHAITTKGR"
     misc_feature    17863..17883
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            17874..18749
                     /locus_tag="O3I_RS05735"
                     /old_locus_tag="O3I_005670"
     CDS             17874..18749
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="O3I_RS05735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005670"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_014981952.1"
                     /transl_table=11
                     /translation="MTINLRKLTKVYRGRTVALDEIDLTVTEGMTGLLGTNGAGKTTLI
                     RILTGTIRPTSGTVAVCGHDMASAAGRTAVKRLLGYLPQELALYPDLTGREFLDYVALL
                     KGIDDKRRRRSQIDNLLDRVGLDAVATQRIERYSGGMKRRLGIAQTLLGDPKLIIVDEP
                     TAGLDPEERIRFRTLLGQLGGDRIVVLSTHILDDVAHSCPRAAVLTEGRMAYHGTTGGL
                     VALADGQTHVLRAAHEPVGDFTVVNVTSTGDGVHYRVVGPVPPPESWPVAPTLDDGYIA
                     LLRAARAGTR"
     gene            complement(18750..19769)
                     /locus_tag="O3I_RS05740"
                     /old_locus_tag="O3I_005675"
     CDS             complement(18750..19769)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.4"
                     /locus_tag="O3I_RS05740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005675"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_014981953.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.3e-27,
                     bitscore: 95.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCPTFNRSAAIRATIDSVLAQTVPDWTLLVVSDGSTDDTDEIVRA
                     YRDPRIRLLRTGPYGHPGGPRNVGAAAATAPAVAYLDHDDRWLPTHLETLLGMLDRGAA
                     FAATGCRRVDETGTELDRTQIPDLIWHPELQTTHAMFEPSRVGHVRTLLAEVGGWTTVR
                     AGYEDWDLWFRTARHGYDFTISAERTALLTVGPGTRRNGLRPPQAVVLQRVPNLSAAQA
                     VLEAIGTPEHRNALRTIHLTEVAHWYTSLTDSDRYRLAEGLRPDTVAGELQAYFEQHEK
                     PCLLEELNYAPIGDHYAILLPLWCATGEHARAIGTVVRERFPAQHRYLRALADATAVA"
     gene            19973..20341
                     /locus_tag="O3I_RS05745"
                     /old_locus_tag="O3I_005680"
     CDS             19973..20341
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022170.4"
                     /locus_tag="O3I_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005680"
                     /product="DUF2511 domain-containing protein"
                     /protein_id="WP_014981954.1"
                     /transl_table=11
                     /translation="MTGAALCGAVAISACGGGSGPKDPAHRDGVALPEPTSSSQAVGSE
                     NLGYLWPFTVDRGTIECRAGEQATFTAPDGKIYALNEKAEQSGLPGVEPLRATGAGGDK
                     ISLGALRSRAMQLCRFAN"
     misc_feature    complement(20418..20433)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.55"
                     /tool="antismash"
     gene            20440..21573
                     /locus_tag="O3I_RS42400"
                     /old_locus_tag="O3I_005685"
     CDS             20440..21573
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037650.4"
                     /locus_tag="O3I_RS42400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005685"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_014981955.1"
                     /transl_table=11
                     /translation="MTKRGTDTRPDLERLIHVAGAGDDLIAEHIEWMGVERTARTLVRE
                     VLDRVDLRGCPPIDVLFRLHAGAQSADVTVRVAADGSTTTPSAPSSGAVAATVEQSLPE
                     FVRSVLGPRGAATSATRVLHWPDLSAFETFGRPQPAFEPVRRLLDSIDHGYRVTLAELC
                     VRAGSDKWGVHQYPQHYAKHFEMLRDRPLTMLEIGVGGFADPRRGGESLRMWKRYFPRA
                     SVYGIDIIDKSELSEPRMTVLRADQSAPADLARVLETTGPLDLVIDDGSHLSAHVIASF
                     DVLFPALRPGGMYVIEDLQTSYWPHFGGRSGVYDNTATSMGFLKALIDGLNFAEIDGRE
                     PRRTDTAIKGMHFYHNIVFVEKGENRDEGAPAWLRGA"
     gene            complement(21575..22918)
                     /locus_tag="O3I_RS05755"
                     /old_locus_tag="O3I_005690"
     CDS             complement(21575..22918)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005690"
                     /product="hypothetical protein"
                     /protein_id="WP_014981956.1"
                     /transl_table=11
                     /translation="MSVITRAEPQHEPAEESAVTAWRPLTRIVFRFCVSYFGLYAVLTQ
                     LISPLFGFFSSPSAGVNVSGLMTPLVDWTAAHIFGVRAPLVHAATASSDRTYDWVLLFC
                     LLVIAAVATLVWSVLDRRRTRYPTLLAWFRVFLRFTLAGQLMLYGIAKILLTQMPSPPL
                     TTLVSPFGELTPMGLLWSSVGAAPGYEIMIGSFEAIGGLLLVLPRTTTLGAVLGTVGLT
                     QIFVLNLTYDVPVKSMSLHLLVMTLVLLAPELGRLFDVLLSRRPVGLSTQPPLFRAHRA
                     ARIALAAQVLLGLWIAIPIVGDCAAAWREHGASRAKPPLYGVWNVERATEEGKEVPLLI
                     TDEKQWRRVFFEYPDEFKFQRMDDSIGFYRATVDVTGHRLALSRYDRPDQVTELRVDTA
                     GPDSLKLSGTLNGHRTEIWLRRLDLASLPLLSRNFHWVQDYPYNPNSR"
     gene            complement(23095..23391)
                     /locus_tag="O3I_RS05760"
                     /old_locus_tag="O3I_005695"
     CDS             complement(23095..23391)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005695"
                     /product="hypothetical protein"
                     /protein_id="WP_014981957.1"
                     /transl_table=11
                     /translation="MTEPGTQQWQILFPNGLTADQVARLAEFAANNGIEQAAHGVDDRA
                     VFRYDFDRATVELYRHLFQKMLDGAELTANNRLVLADRLAELDAWAETASATD"
     gene            complement(23405..23797)
                     /locus_tag="O3I_RS05765"
                     /old_locus_tag="O3I_005700"
     CDS             complement(23405..23797)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O3I_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O3I_005700"
                     /product="hypothetical protein"
                     /protein_id="WP_014981958.1"
                     /transl_table=11
                     /translation="MTDLDHSNNDTADAPTAAGPWQIRFEPGTTKENIARIADFAVAEG
                     MCDPGSADVVRAGRDPRFWHSGALDRAEVDAHREVLRKALNNEPLSAADLDPIRDAVQR
                     FDEWLGTLAYPREEIYDADTTFFDFD"
     gene            complement(23790..24209)
                     /locus_tag="O3I_RS42405"
                     /old_locus_tag="O3I_005705"
     CDS             complement(23790..24209)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026864.4"
                     /locus_tag="O3I_RS42405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O3I_005705"
                     /product="toxin C-terminal domain-containing protein"
                     /protein_id="WP_014981959.1"
                     /transl_table=11
                     /translation="MITIRKSFAAALFATLPLLALTSAQAAAAPSESAAAPTATIVVDA
                     DTPGVPPAFQAVAGKRFTDAEDRAAARDLGYAVANVGKSHGCLIFKHEKKNLYISQDVD
                     GHNGGRWKMASSPENLASKKTRMGTYDANLNRIGD"
ORIGIN
        1 cagcccgctc ggcggcgtcg acaagatgct cagcggcatg ccgaatgtgc tggccgagca
       61 cgacatcgcg ttcgtccccg gcctgaacga ggaactcgcg gccacctcgg tgtgggggag
      121 tcaggccgac ctgccggccg gtgcggccac gcacgacggc gtcgtcggcg tctggtacgg
      181 caagggcccc ggccttgacc gcgcgacgga tgcgttgcgg cacgccaata tgtacggcgc
      241 gaacgcgcgc ggcggcgtgc tgctgctcgt cggcgacgac ccggcctcca agtcttcgac
      301 cgtgcccgcg gtgagcgaac gctcgctggc cgcgatgggc attccggtgc tgttcccgcg
      361 caacgcccgc gagatcatca cgatgggtct gcacggggtc gcgctgtcgc gcgcctccgg
      421 ctgcctggtt gcgctgaaga tcgtcgccga tgtggccgac ggcgcctgga cggtcgaggg
      481 caacgtgggc gacatcgaca tcacggtgcc cgagatcacc tgggaggggc gcccgttcag
      541 ctacctgcag cgtccgatgg ccgcgccgac cgacagcgtg atcgccgagg cggatctgta
      601 cgggccgcgc tgggagacgg tcaaggcgta cagcacgctc aacgaactcg atgtgatcga
      661 ggtgaacccg gcccaggcca cgatcgggat cgccgccacc ggaacgactt tcgacgcggt
      721 gcggcaggcc ctgatcgacc tgggggtgga cgacgaggcg ctcatgcggg ccggggtccg
      781 gctgctgcgc atcggcatgc cgtatccgat tgcgccggaa cgggtccggc agttcgccaa
      841 ggggctcacc cggctggtgg tggtcgagga caagaccgcg ttcatcgaga cgcagctgcg
      901 tgaaatcctc tacggcaccg ccgatgcccc cgagatcatc ggtaagcgcg acgccgcggg
      961 ccgcccgctg ttcagtcagg acggcgagct caccaccggc cggatcgcca agccgctgtg
     1021 ccgcgcgctc gacggtttcg tggacatgaa acgaccgctg ccgcagccgt tgtcgctggc
     1081 cgtgctgccc gccaagcgcg ccgcctactt ctgcagcggc tgcccgcaca accgctcgac
     1141 cgccgtgccg gagggctcgc tggcgggcgg cggcatcggc tgccacacca tggtgaccat
     1201 gtccggtcgc gaggacagca aggtcaccgg cctcacccag atgggcggcg aaggcgcgca
     1261 gtggatcggt caggcgccgt tcaccgacgt gccgcacctg ttccagaaca tcggcgacgg
     1321 aacgtatttc cactccggcc agctcgccgt gcaggcgtgt gtcgcggcca aggtgaacat
     1381 caccttcaag ctgctctaca acgacgtcgt cgcgatgacc ggcgcgcagg acgccgaggg
     1441 cgcgctcgcg gtgccgcggc tgacgcacaa gctcgccacc gagggcgtcg cgcagatcat
     1501 catctgcgcc gacgagccga agaagtaccg caagcgtgac ctggccgcgg gcacccggtt
     1561 gtggcaccgc gaccggctcg acgaagcgca gcgcatcctg cgcgagatcc ccggcgtcac
     1621 cgtgctcatc tacgaccagc actgcgccgc cgacgcgcgt cgtcagcgca agcggggcac
     1681 cctgccggta cgccagaccc gggtggtcat caacgaggcg gtctgcgagg gctgcggtga
     1741 ctgcggcgtg aagagcaact gcctgtcggt gcagccggtg gacaccgagt tcggccggaa
     1801 gacccggatc gatcagacct cgtgcaacac cgattacagc tgcctcgacg gcgactgccc
     1861 gtccttcgtc acggtggaac tgcccgatcc cgggaaagcc aagaagcgca agagcactca
     1921 gcgtcccacc ccgcccgtgc tgcccgacct ccggcaggat ccgccgacca cgacgcagaa
     1981 cgtcttcctg gccggcatcg gcggcaccgg catcgtcacc gtgaaccagg tgctggcgac
     2041 cgcggcgctg cgcgcgggct acgacgtggc gagcctcgac cagatcgggc tcagccagaa
     2101 ggcgggcccc gtcgtctcgc acctgcggtt cgtcgcgggc gaactggagc ccgcgaaccg
     2161 gctgaccccc ggctccgcgg actgcatcgt cgccttcgac ctgctcaccg cgaccgacaa
     2221 caagaacctg gcctacgggt cgaaggagac cacgctctcg gtcgcctcca ccagcaagac
     2281 cccgaccggg gacatggtct acgacaagtc ggtgcagtac ccggagacgc ccgcgctgct
     2341 gtcccggctc gaccaggcct cgcgggacct gcgttcgttc gacgcgctcg gcgcggcgga
     2401 ggtgctgttc ggcaacaccg cggcggccaa cttcctgatg gtcggcgccg cctaccagct
     2461 cggcggcctg cggctgccgg cggcggcgat cgaggaggcc atcgagatca acggggtcgc
     2521 cgtgaacgcg aacatcgcgg ccttccggtg gggccgggtc gcgatcgccc gcccggacga
     2581 gttcgccgcg gcgatcggcc gtccgcagcc cgaacacgcc gagatcaagg ttccggcaga
     2641 ccttttcgac acgctgaccg ccaccggtga gacccggcgg ctgatcgagc tgcgcgccgc
     2701 ggagctgatc gggttccagg gtgtccgggt cgcccgggac tacgtgacga cgatgcagcg
     2761 ggtgtggacg gcgcaggagc aggtcaccgg acgtaccgag ttcagtgagc aggcggcgcg
     2821 gggtctgttc aagttcaccg cgtacaagga cgagtacgag gtcgcgcggc agttgatcga
     2881 cccggccttc ctgaaccagg tggcggatca gctgcccgag ggcaccaacc tcacctacaa
     2941 gctgcacccc ccgatcctgc gcgccatggg ccgcaagaag aagatcggca tcgggccgcg
     3001 cgggcatctc gccctcaagg tcctggccaa gggaaagcgg ctgcgcggca ccaagttcga
     3061 catcttcggc tacgcgcacg tccgtcgcgt cgagcgggaa ctgctggcgc attacacgga
     3121 aatggtgctg gcactggcgg gttcgctcga cgaggcgagc tacgaccgcg cggtccaggc
     3181 cgccgcgctg gccgacacgg tgcgtggcta cgagggcgtc aagctcgcca atgtggaggt
     3241 gtaccgaaac agcctgcgcg acctgggcat cgagccgccg caggtgtgaa gcagcgcggc
     3301 ctgggcagta ggccgcgcgc ctggtcgagc gtaaaggcca cgctcccagg catatgagaa
     3361 gcgacccgga accgcatcgg ttccgggtcg cttcgctgtc gggaccacgc gtcaggtgtt
     3421 cggcctgcgg tggcggcaga cggtgacggc cagggtggcc ggcggggtca gcgtgagaat
     3481 cccgagcacg gccaccacga gcggcgcctg cgcgggcagg gcgaggcaca gggcgaccac
     3541 gcctgcggtg atgacgaggg cgagtacgga cacgccgaag ccgtgccagg tccggcggcg
     3601 gccgagcgtg cggccgcgcg gggccggcag cggggcgagg ggcgcgggat cgggtgcggg
     3661 acccgccacg gcggcatcgc tgcggacggg atcgggcgtg agcagaggca ctgtcgtctc
     3721 tcagggtcag tggacaagtc gcgcaggcaa tacccgttcg ccggcggctc aatcagcccg
     3781 aatcggtctg attttccgac accgccgcgg ccatccgaac ctcgatcgtg caccgggccg
     3841 gtcgcgggcg acgaactccg gaccgggagc aacactggac ggcccaccgg cgtggtgcgg
     3901 ggatctcgtt gccgcacgcc ggagttcgta cctgacgtgc acccatcata gctgatgcgc
     3961 atggaggcct gtgctgcggc aacgccttcc gcgcggccgt cgccggggcc gccgggagag
     4021 cttctcaaat ctgttgcccc gaaatggaac cgatcggtca tccgccgcgt ctaatcccct
     4081 gactagacac agtaaggaca aaaggtgggg gtttccatga acgctttgca gctgagtcag
     4141 ggcatcgagg cgacggccac gaccaccgcg ttcgcgcatc cgagcctgcg cgactatctg
     4201 gatccggcgg acgggcggtg ggccggtctg ttcgccgcac cgttgcggct cgagttcgcc
     4261 gagtacgacg agttgggcgt ccgtcacgac accgaggggg cgccgatcgt gctccccgtg
     4321 cacaccgagt gccaggccga acagctgcgc tcgattcggg cgcggcacgc catgaccctg
     4381 ctcgtcgcgg tcaccaacga cgtcaccggt cattcgacct acctggcgat ccgggccggc
     4441 gccaacttcg tcatcaacct cgcgatctcg atcgagcggc aagccgaggt cctgcgcgcc
     4501 cggctgctcg accatgtcag cgcgcagccg agaaggccgc gtccgccggt cctgggcgcg
     4561 gtacccgatc gcgccaccgc cgctcgcgaa ccgcgccccg cccgcgacgc agtgcccgcc
     4621 gccccgaacg gcctgcgcgc cgccacgccg atcaaccgac ccgagctgga cgaattcgac
     4681 gcccgcctcc tgcggatgct gaagacctcg atgaccgtcg ccgaaatcgc ccggcagaac
     4741 tacctttcgg agcggtccat gtaccgccgc atccgtaatc tctacgacgt cctgggcgtc
     4801 tcggggcgca acgatctggt gaactcgggt gcgcacgacc atccccgggc tccgctcacc
     4861 gtgcttcgcg gctgaccggg cgcggaccgg acgcacggca gccgcacgca gcgtccgcgg
     4921 cgactccacg actaccgaag gatccgagca tgaaccccga cctcatcgac tacgtgacct
     4981 gggacgacca gcacaacgtt gcctacctcg cactacggca gaacaccgcc ggcccgcgct
     5041 acgccgcacg aaccctcccg gtccaagaca gcacggacaa cgaggtggta gccgcactcg
     5101 acttcggcgc ggacggcgaa ctgatcggca tcgaactcct gcgagccgac tcacagttga
     5161 gcgccgcact gaaggcgaag gcgcgcacag catccgaaac ggagtgatcg gcgatttgcc
     5221 gtgaaccgtc cggctgctac tcgctaccta cccgaggaga ccgaaagaac gaggagatcc
     5281 atggccacca ccgcaccaca tcaggggctc gaaatacgcc ccaggcggga ccaacccagc
     5341 ctgtggcacg tcacggcgac cgaactgtcc aggatgcggc gcggcttcat cggctggttc
     5401 gtgatcctgg tgcccatcgt cctcaccgtt ccgctctatc cgatgtcgct ggcttcgccg
     5461 gagggcaagt ccggccacgc gtggatggtg tttcgcgacg tcacgctcga aggttggggc
     5521 gtcctcattc cgatgacggc tgctctgctc gccgcgctct cggtgcgggc cgaccaggat
     5581 gcctggcggc tgctcttctc gtatgcggta ccgcgaacga agtacctgct gggcaagtac
     5641 ttcgcgttgg ccgcattgtc cgcggtctcg acgacactcc tggcggcact gctgtgtgtc
     5701 ggtgcggcgc tcggcggtcg gctcggcagc agcatcggga ccatcgtcgc ggcgagcttc
     5761 ctgccttggc tggcgggatt gggttgtgct gcagtggctt tggtcgtctc gatggtgtgg
     5821 ggtctcgggc cgaccatcgc gatcggcgta gtcggcatga tgagcggcat gctcatcgcg
     5881 gacaagacgt ggtggatggc ggtgccgttc gcctggccga tgcgcgtcat cctcccgttg
     5941 gccggcatcg gacccaacgg agttccgctg cccgccgata gcccggtccg cgatcacggg
     6001 gtgattctcc ccgcgatcgc cctgtcgttc ggactggcgg cggttgtcct ggcgctgggt
     6061 tcggcgcacc tcgagcgcaa ggagatctga ccgtgtcggc gttggaagtc tcgcaactgc
     6121 acaagcatta cggaaaacat cgcgcgctcg acggcgtgga gctgtcggtc cgaacgggcg
     6181 aggtctatgg tctgctcggc cccaacggcg caggcaagtc caccctgatg aagaccgtgc
     6241 tggggctgca gcggccgacc agcggacaca tccaactgtt cggccggccc taccaccggg
     6301 cgcagttggt cgatgtcggc gcgctgatcg agactccagg actgtggccg aagctggacg
     6361 cactgaccca tctacgcatc cacgcgaagc tgcgcggcgt gcccgaggcc tggatcgatg
     6421 aggcgctggc cgtggtgcaa ctgaacgacg tgcgggatcg caagattcaa gccttctcgc
     6481 tcggtatgcg ctggcggctc ggcatcgcca tcgcattact cgcgcgaccg aagttgttgc
     6541 tgctcgacga gccgaccaac ggactcgacc cggtgggcat ccgggagatg cgcgggatca
     6601 tccgttcgct cgctgccaac ggcaccacgg tgtttatttc cagtcaccag ctgtccgaga
     6661 tcgcgcaggt gtgtgaccga gttgcggtgc tggtagcggg aaaaacccgc tacgagggaa
     6721 cgctggaggg catcgcgggc gacggtgatc tcgaagcagg attcttccgc atcctcgaat
     6781 cctgtgattc gcgtattcgc tgaagcgcgc gggcgcagtg ccgagtaagg gcgatccgaa
     6841 cagccgattc ggatcgcccg gcatcctggc tcgcaaagcc gaagccgccg tcggcctgct
     6901 gctgggcaag caggaaacct gtcgcgcgca acggaagggg acgttcggtc agcccgagtt
     6961 cggcgcagcc gcacagcagc gtggcgagcg cttcgaggtc gtagcgccga atcgccagca
     7021 ccagtagcga atccagtact accgcccacg tggtcacggg tgcggttgac gcggcgaggt
     7081 tgtcgagggc gcgccagcgc accgggtccg cgcacagcag gtccatcggt gccggctccg
     7141 aaacatgctc ctgcgtactg gcttcggcga tcgagccgac tccgtcgtcg agtgcgttgt
     7201 cgatgccgat cagccacgtt cgggcagcgc cgagtgcgtg ctgtgtgcgg gaccgctgtg
     7261 tttcggcgac atcatcgagc accgtggcgc tcccgttctg ctgcggccat cgccgcgacc
     7321 atggtggtgt ggtggcaggt tccgaaggaa tagccctcgg cgacctcgcc gcgcaaagtc
     7381 gaccagcggg ccgggtcgaa gagcggaccg ggcacggcgc cgtcggacag cctgtgccgc
     7441 gccagtgtgt gccagccgtg cgtggtcaac gcgcagtcgg gctgtccgat ggccagcaga
     7501 cacagcagta gttcacccgc tagatccatg tctccgaggg cgagataggt gccgagcagc
     7561 gtgcgcaggg cctcgacgag ttccggctcg gccggcgtcg cccgtgcggc gaaatccgtt
     7621 gcgtagaaaa ggacgtgggt gagcgcgtag acctcgtcat cccgcagata gagggggtct
     7681 ggcgcggccg cgacgatgga gagttcgagc agctcggcga tcggcggcaa cgggttgggg
     7741 aactggccga gctcgaggac atagtgcaac tccaggcgac tgagcggagt acgccaggca
     7801 ccgtgctggc cgccgcaacc ggtggcgagg accgtccgaa cgcgctccgc ggcactcggc
     7861 accggcctac cgagatcggc gagcagcgcg accaggtacg tgcgatacgg aaatttgtcg
     7921 tcaccgagac ccagtgccgc gtggaacgag tccgtggcgg ccagcgaatg tgccagctcg
     7981 accgccccct cgatgagcgg atgatcgtgg aatcggccac ggcgcaggat gcgacagagc
     8041 atgagcagtt cgagcgcggc gccttcgcgg aatggccggg gcggcagcat gcgctcccac
     8101 ctgtccgggt cgaaccaacg gaggttggcg tggagccacg ccaccgcctc gtccaaaatc
     8161 ggcccgtcgc cgcggtattc gatccggctg ggcggaggcc agaccgggta gccggtgacc
     8221 tgtccgcgca ggcccgcgtc gaggtagcgg ccggccatcg gcgtcactgt ccgatcctga
     8281 ggcggatcgc caccgcgaag aacaccgcga gcgccgcgag caccagcaca tccaccccgg
     8341 ccgggacgag gccgcgttcg gcacccacca ggacgtgcct gccgagatcg accaggtagg
     8401 tcagtgggtt gatccggatc agcaccgaca gccaggtggg taccacctcg ggttgaaaca
     8461 ccgacccgga gaggaacagc atcggcagca tcatcatctg cacgctcgcc tgcagcgttt
     8521 ggatctggcg gaaagcggtg gccagaaaca agccgagcag actgaacacc gcggaaccga
     8581 acaggtagat cagcatggcg acggcgatct gacccatggt cggtgtcagt ccgaaaaccg
     8641 gtgcgcacga aagcaacagc aggctctgta ttccgacgat gacgccggtg ctcgccactt
     8701 tgcccagcgg caggcacatc cggggtaccg gggcgacggt catctcgcgt aggacgccga
     8761 actcgcggtc ccaggcatag gacaggccgg tagcgatgcc gatagtcgcc acctgaatgg
     8821 cgatgatgcc cgggaggatg tacgcgctga acgacaccga gtcgacggtg ccgaccatgg
     8881 cgtcgaaacc tacggcgtag atcgcgatga agaacagcag ttgcgcggca ttgctgagta
     8941 gcagcccggg acggcggagc tgacgttgca ggtcccgtcc cgcgatcacc gcgatcgccc
     9001 ggacaccgct gaccatcgcg tgttcccgcg caggggcggc agtcgggtgc atcgttgtca
     9061 tgaaatgcct ttcccggcgc gggcggtggc cgcgacatag acgtcgtcca tcgacgggtt
     9121 gtgcacggtg acgctcgaga tcggcagttc gaggacgcgc acgatatcgg cgacgcggcg
     9181 atcggggtcg gtgcatcgca cctcgagctc ggtgaagccg gtgacgacct cgaaacctgc
     9241 cgtgcgcaac tgcgcggcgg cggcctcgtc gtcgtgtgtc cgcagccgaa cacaggagac
     9301 ccgtaactcg tccttcaact cgacgggcga accggagcga ccgatccggc cgtcggacat
     9361 gatcacgatc tcgtcggcgt attcggcctc gtcgagatag tgggtggagt acagggtggt
     9421 gacacctagt tcgtcgcgca ttcggagaag atctcgccaa acgacgcgac gggatcgtgg
     9481 atcgagaccc gtcgtgggtt cgtccaggat gagcagtccg gggcgatgaa gcagtgcgcg
     9541 aacgagttcc acgcgtcgcg ccgtgccgcc ggacagtcgt tcgaccgcgg tgcgtcgctg
     9601 cgcggtgagc tcgagcaggt cgagcaagcg gtcgatctgc gcggcggtgt cggctcggcg
     9661 catgccgaaa agccgggcat ggaaccagag gttctgctcg accgtcagtt ccttgtccag
     9721 ggtgcgttcc tggaacacca gaccgagttg ggcgcgggcc cgcatcggtg ccgtccgtac
     9781 atcgctgccg aagatccgaa cagtgcccga ggccggccgc gctgctgtcg agagcacatt
     9841 gagcaggctc gactttcccg caccgttcgg cccgagcagc gcggtcagct tgccgggtac
     9901 ggaacgcaac gagaccgagt cgacggccag tgtgctgccg tagcgcacga cgatatccga
     9961 gagctcgaag gcgttgactg ccatcggagg atcccctttc tcagctcagc gcgaggacac
    10021 gatcccaggg atgccgtgcc gtctcggcac tgctgtccgg gagcaccgac agcagcgcgc
    10081 acgccacccc ggccgcaccc tccagcagtc cggcgatatc gagcagcttg aattcgctcg
    10141 gccccggcgc ggatctcgga tatcgcatcg gctgccggaa cacgaagggt gcggccggat
    10201 ccgccatgtc gaggatcgtt gcggcgagcc ggtgcttggc ggccaggagc acgtcgtcct
    10261 gttcggcggt gccgatccga tggaccacct ggagcaaccc cgcgtaaccg tggcaaatcg
    10321 tcggtcccgc cagggtccat cgcgattcgt cccgggcgag tgcgtcgtgt agtgcctgga
    10381 cggcgtgcgt gcgccattcg gggatgtcga gggtctggcc ggcgtggtgt accgctgccg
    10441 cgacgcccgg cgcaccgtaa caccatgctg tcctggtgaa cagatcttcc gttgcggtgg
    10501 tggcgatttc gtcatcgaac ggtatgcgac acggccagta gctgccctga tcgtccgtgc
    10561 gaagccagcg gatcagccac tgcaccatgc gcttcagcgc cgcccgctgt cccggcacct
    10621 cgtgcccgcg gcgcaaggcc gtcgacagaa ccgataccgg tcctggaata ccgtgtgcga
    10681 gaccgagatt gaaatcgccg cgcggatagt cgagccggtc ctgctcgacc gcttgccgcg
    10741 ccgcgggaac ccaccagccg ggcacgacat ggccgtccac ggtgatcggt tcgctgatct
    10801 gcaccaggta ctgcaaggtg tcgtagaggg cgcgccggac ctccgcgccg ttctcgacgg
    10861 gatcgtcgag cgaatcgagc aatattcttg cggtgccgga caatccgttg acgatgtcgt
    10921 agcactccca ggaaattccg ggccccggct gggcgcgtag gcgccgcagt cgggtcagct
    10981 ggtcgtcggc cagccaggcg gcgagcttgc ggcgcaatcc gggatagtgg ccctcgcagg
    11041 tctgcgcggc cgccagcagc gccgccggtc ccgcgtacag cccccggctc ggctgactcg
    11101 acatcgtctc gcccgccgcg cggacgtggt cgtgggtcgt gctcgaccag gacggcgtcc
    11161 ggcgcgccaa ctccgcgtag aacatcgctg tgccgggcaa tccggtggac aacgtcatcg
    11221 gtccccacat caccgacccg tagatggggt cgtgattgtc ggggcgatcc gcgatcgtcg
    11281 cgacggcggc gggatcggcc agccgttccg cgaccagggt gacgagttcg gccgcccgtt
    11341 cggccggcga aacttgttgc ggtagcgcgg tgctcatcgt gcgtgccttc ttttgttgaa
    11401 gttgtcctgc acggcgccgc gggcaatggc gaccgccgcg cgctcgcggt cggagtcacc
    11461 accgaagagt cgattgcagc tcatgtgcat caggctgccg acgagccgtt ggtgccggat
    11521 cccggggtcc ggcaatactg cgcgcagttc gcggacggcg gtgtcgcggg cgtggaggac
    11581 gtccagcgca gccgcaccgt acgggtcggc gcgcagtccg tcccacccgc cgtgcgggtc
    11641 gacgagccgc cgccagttct gtgcgtccac ccggtaggcc gcaggcagct cggctcgtgc
    11701 accggtcatc gacagccagg cgaaggccgc gtcggtttcc cgccggttgt cctgcgccgg
    11761 gttcgactcg ggcagaccgt aggcggcggc gagcgccgcg acggagaccg cggcgaaggt
    11821 gtccagtgtg tgcgggcacg agggatcgtc caccagctcg agaaatcgga tcgccgcgcg
    11881 actgtccgct tcgaacacgc gctcggccat cgtcatggtc gccacaccgc cgtaccgttc
    11941 cagttcggcc tcgtagggtt cgatacggtg cgttctgatc agcccctcgt gctgccattg
    12001 ctcgagtcga cgtccgagtg acgacgcggc cgcaccccac agatccgcgg ccgtgccgtg
    12061 gcatcgaatc cgcagatgcg gcccgttcgg cccggtgtac cgaatgaaga accaacggtc
    12121 gcaaccgttt tcctgagccc gctcgaccag gccgggcagg tgcacacgga ggaactcgct
    12181 ctgctccgcc accgggagat acaactcgag cgagagccag tcgctgccga gcccggccgc
    12241 tgtccgttcc accccgaggc ggccaccgtg cggcgagcgg gccgggcgag tgtcgcgccg
    12301 tgacaacggc acgacgatct ccatcgcgtg cccgtcgata ccgtcggaat actcgtcgtc
    12361 cccgggtaac tcgtgcgcga cgaggccggg gtccttgcgc agttcgtccc acagcagttc
    12421 cagatgggcg ggatcggtca ggtcgaacag caaccgctga tccatctgga cggtcaggat
    12481 ccgttcgggc acccgccact cgcgccgcca ggccgcgacc gcggccgcga agtcaggttc
    12541 ggccacgccg aggagcgtgt ccatccgcca caccgccgga gccagcacga aacgaccgtg
    12601 cctgatccgc ggcacgaaag gcagttcggt cagcccggcc caggtccatg gctcccacag
    12661 tcgttgtccc tccaacccga tctcccacag cagtcgggcg gcgttgggcg cctgggtcat
    12721 cgggctgatc atgttgttca gcaccggaac gatctcccgg ccggtcggca gatgtaccgc
    12781 gcacaaccgc tccgtcgtcg caccgacggc tacctcggcg agggggatct catcggtgcc
    12841 gcgggcggcg ggcagtccga cgctgatccg ggctccgctg tgcaccgcac agtgggcgag
    12901 gttcgccgct ttgccggaac gtgtcatgaa ggacaggtcg acgcgcatcg cgccgtccac
    12961 gtggaccgga atcgccgcgg actccgccgc gagctcggcc cgaatctccg ccggcagcag
    13021 gtcggcgaat cgggcgagtg tcgcccccgc atggtgtgag cccgggctgg gtgccagcac
    13081 gatccggaag tccccggcgg acagcgcgtc cagcgacgcc gcgatgacgt ggaaggtgat
    13141 ctcgcaggag ttcggcgcgt ccgcgtcgcc gtcgttcgcg ccgatcaggt cgttcagcgt
    13201 cgcgtcggtc agctcgacct cgcgcaggcc gtcgcgtagt gcgataccga ccaggttgtg
    13261 cagcagtcga attcgggccg gctcgcgacc gatcgccgga tccggcttcg tctcttggct
    13321 ttccggccag atgtacccgg cgggtgcgcc catgccacgc gtggcgtcga gcagctcgcc
    13381 gacgcggacc agccgatcgg taccgtagcg ctcgaggaac ttcgcgtgat agtcgcgcag
    13441 tgcgacgagg ccaagtttgt ctgccgacat ccgccacatc aactcggccg cacgctcgac
    13501 ctcggcgcgc acctcgagcg gtagctggac gtcgatatcc accgccgagt cgatgtgcag
    13561 cggtgtgtcg taagagtgca ggcggtccgc ctgcgctgcg gtctcgatca accgcgcggt
    13621 cccgggcccc aggggcagta gatcactcga tcgcctgcgg tcatcgattt cacgcagtgc
    13681 gcgcagcgtc gccgcgatcg gtgtggccgg atcctcgatg gacgcgagga cgtcgatcac
    13741 gtggccgagc gggtcgccgc cgtccagcgg tggccgcaac tcggtgagca agaattcctg
    13801 ctcgaccaag acccgtagca cctcggcaac gcggcgcggc ggggcgccga aacgtgccgc
    13861 gatcgttgcc gtgagttcgt cgatcgagac catccgctcg gcggcgcgca gcgcggcctg
    13921 gaccaccggc gagttccgta gcgacaccac cgccctggtc tgcccgtcga gcggtgcgcc
    13981 gagcggtgac gggcagtcga gcaccacccg atcgccccga ccggacagcg ccgggtgggc
    14041 cagcacccgt agtccgggta gcagctccgg cctgctctgc aactgctgca cgacaccgag
    14101 cagccattgc atgtctgcat gtgtcctggt gcggtggcgg gtgccgcggt cgagcttcgc
    14161 cgagaaatcg aatcggccac ccgtcacgcc ggagaagacg ccgaacggcg tagggcgcat
    14221 ccgcgttctg atgtcgtagc ggagtaccgc gagcgcggcg cggcgcaact gtgtcgcttt
    14281 gatgccgcgg tgttcgccac ggtggacgcg gtcgagcagg ttgccgagac tcgggctggc
    14341 gagcgtgatc gcggtgcgca gcgtgctgtc ggccgcggcg gcgcgcacga tgccgaggtg
    14401 gccgcccccg gtcggtatgc cggggcggcc gagcgccagc ggagcgcgga gcatgaagac
    14461 atcccaggca cggaagatcg aatccgacac cagcccaaat cctttgcgat ggtcgacgac
    14521 atggggcgcc cgggccgcgc gatgcggcgc ggcccgggcc tggtgatcaa cagcagtggc
    14581 tgcagccgct gccgccaccc gagctggtgc agcccggggt gcagtacgac cagctgttga
    14641 tcgccgcgtt gccctggatg ttgccgacgc cgacgcggat gtcgagatcg aacagatcga
    14701 ctgtttcgac ggtctccacc ggttccatgg tcaccgtgct cacggtgttc tcctcttctg
    14761 tggcactgcc cggctgatcg aacgaccagg ccgagggagg cccagcgttc ccaccgggcc
    14821 ggccggccgg tgctgttccc ccggtaacga gacaagcacc gcaccccacg cggcgacaac
    14881 gtctcgaccg gtatctggca gcgtccgagg ccgctgccaa ctctgcgcgg cgcgccgaat
    14941 tccgatccgg gttgaaccgt tcgccgcgca cccgctacac acgactgtgt ggactcggac
    15001 gaagcgttgc tggccgcggt ggccaagggc gaccaggcgt gcctgcgtgt gctctacgac
    15061 cggcacgcgc ccgcgatgct gcgggtggtg cgccggatga ccgcgcagag cggggtcgcg
    15121 gaggagatcc tgcaggagac ctggctggcc gtgtggcgct cggcggacag tttccgcggc
    15181 gaatcctccg cgcgcggctg gctgttcggt gtcgccaaac gccaagccca caactacctg
    15241 cgtaagtcgg tgctcacaac agtcgatctc gacgagacgc cggaactatc cgatcacgcg
    15301 ggcacggtgg aagacatcgt gctcgccaac gccgcccgcg gggatctcgc ggccggcatc
    15361 cgcgacctgc cggaacatct tcgcgacgtc ctgttgctgg tgctggtcga cgatctgtcc
    15421 tacccggatg tcgccacggt gctcgacatc cccgtgggta cggtgaagag ccgaatgtcg
    15481 cacgcgcgca agcgacttgc gcagaccctg tccggcacca ccgccgatct gtccattcgc
    15541 tacggaggcg agcaatgacc agcccgaaca ccgtgggccc acacctctcc gacgatcaac
    15601 tgatcggcgt gccggacgat gccgccagag cgcacctgcg cgcctgctcg gaatgtcagg
    15661 cacacgccca gatttggcag cagatggcag tcgcggcccg ccaggtttcc gccgacctgg
    15721 tgggcacggt tcgcacgccc tccttcgata cgttgctcgg cgatgcgctc ggaatgccct
    15781 gggcgacaac gaacgaagcg gtgcggccgg ggtggcgagc ctcgctgctg ctgacggcga
    15841 cgctggctcg ggcacagcta cggctgctgc cccgggcact ggttctgctg agcgggctgg
    15901 gcttcgtggg gtcggtgctg ctcgctgtgc tgacgcggca cagcggcgcc gccgcaccgc
    15961 tgttcggtct cgctgtgacc ttgctcttcc agctcggcac gctggcaacc tgcatcccgc
    16021 gatccgatcc acggttggag ttgttcgcca ccgtgcccat cgcgccggcg gcggtgttcg
    16081 cgtgccggct gatcgtggtc ctcgccgccg atctcgcgct ggcactgctc gcctcgctgc
    16141 tcgccagcgg tttgggtgcc tccgccgatt tcggcgcgat ggtcgcgggt tggctcgggc
    16201 ccgcgttgct cgcctccgcg gtcggcgtcg ctggtgcggt ctggcgttcc ccgccggtgg
    16261 gcgccgccgc gggcgcggtg atgtggctgc tcggtgcggc ggccgccgcg gacgccggac
    16321 cggcgcaccg cgtcggcgcg ttgatcgcac cgctgtggtc tacctcggtg ctcacgctgg
    16381 cggtcgccgc gctgctgctg gtcgccgccg cggccgggat gagcaggccg cgctaccgca
    16441 ccgtggccgg atgaaccgaa tcgagcggct cggctacgac accgaggtga acccgatctg
    16501 gcggtacgag atccggcgct gcgggctcgg cgtgctggcg ccgacgcccc tggcgggcgt
    16561 cgtcatcggc atcgcgctgg tggctttcga cggcgcgatg atcctgcgca cggtcgccct
    16621 cgaggtcgtc ccgctgacgg ccgggctggt cactgcggcg gtgctgggcc gagagcggat
    16681 gctcgagttg cacctgaccg tgcggacgcc gtacccgcag accgttgtgc gccgcctcgt
    16741 cctggtcggg gcatcggtgt gcggtgcggt ggcgtcgatc ggcgcgctcg gctggtccgc
    16801 ggcggccgtg gccgcaggac ctctgctggt gagtacgccc gcgttcgccc tcgcgctgat
    16861 cagtgtcgcg accttcgtcg tcgtcgcctc gggttccgcc gcgggcgcct cggcgatcgt
    16921 cgtgaccgtc tggtcggcga agctgctagt tctggatcag atcatgcgcg gcgtgtgggc
    16981 acaggccgcg gtcgcggtga cgctggcggc actgttcgca tgggccgcag cggtgcgggt
    17041 cgcggacagt gaggcccagc tgcgtgaggt gcgagcatga cgggccgctc cttcggggcg
    17101 ctcggggcga ccatccgcta cgaggcgttg ctctccttcc ggcaccgcac ggtgtggctg
    17161 tcgttgctgc cgttggtcgc gttgatcatg gtgctcgggg aattcccgta cggccggaat
    17221 cgaaccggcg atatcgccgc cgtgggcgag accgcattgc tgatcaattt cctgggctcc
    17281 ctcggtatcg ccatcgtgct cgccgatcgg ctcgccggac agcggcgacc aggattgcgt
    17341 gaattgttcg gtgccacacc agccggtgga ctggccagaa cggcaggcct ggtcctggga
    17401 ccctggctga tcgcctcggt gcccgcggcc gtggtcctgg tgagcatggg gggatggctg
    17461 gcgatcacct cgggtggacc cggaccgctc ggcgcggcgg tgatcggtgt gctcaccgtc
    17521 gtggcgcccg gatccttgct gctgaccatg gttgcgaacg tcgcggccct gctgctgccc
    17581 agcgccgtcg cgcgtgttct cctggtgccg ttctggtact gggcgacgct gctcacgcca
    17641 ctgctcccga tccccacgcc ggcccggacc gtgtggtcgc cgctcggcga ttaccaagcg
    17701 gcgcaatggc tcgaggtcgc actgcccggg cgaaccggcg gctggctgta tccggcggtg
    17761 agcgttacgt cctcgattct cgcctgcggg ctcaccctcg cggtgacggc gctcgccttt
    17821 ctcatcggcc acgcgatcac gaccaagggt cgttgagccg gaatggagtt cgaatgacga
    17881 tcaacctgcg caagctcacc aaggtctacc gcgggcgcac ggtcgcgctc gacgagatcg
    17941 acctgaccgt gaccgagggt atgaccggct tgctcggcac gaacggcgcg ggcaagacca
    18001 ccctcatccg cattctgacc ggaaccattc gcccgacttc gggcacggtt gcggtctgcg
    18061 gacacgatat ggcgtccgcc gcgggacgga ccgccgtcaa acggctactc ggctatctgc
    18121 cccaggaact cgcgctctat ccggacctca ccggtcgcga attcctcgac tatgtcgcat
    18181 tgctcaaggg gatcgacgac aagcggcgcc gacggtcgca gatcgataac ctgctggacc
    18241 gtgtcggact ggatgccgtt gccacccaac ggatcgagcg atactccggc gggatgaagc
    18301 gccggctcgg catcgcgcag acgctgctgg gggacccgaa gctgatcatc gtcgacgagc
    18361 cgacggcggg gctcgatccc gaggaaagga tccgcttccg caccttgctc ggccaactcg
    18421 gtggcgaccg catcgtcgtc ttgtccaccc atatcctcga cgacgtcgca cacagctgcc
    18481 cgagggccgc cgtgctgacc gagggcagga tggcctatca cggcaccacc ggcggtctgg
    18541 tcgccctggc cgacggtcag acgcacgtgc tgcgtgcggc gcacgagccg gtgggcgatt
    18601 ttaccgtcgt caacgtgacc agcaccggcg acggggtgca ctatcgagtg gtcggtccgg
    18661 taccgccgcc cgaatcatgg ccggtggcac cgactctcga cgatggctac atcgcgttgc
    18721 tccgtgccgc cagggccggg acccgctgat cacgccactg cggtcgcgtc ggccagcgcg
    18781 cgaagatacc tgtgctgtgc ggggaagcgc tcgcggacca cggtgccgat cgcgcgtgcg
    18841 tgctcgccgg tggcgcacca cagcggcagt agtatcgcgt agtggtcgcc gatcggtgcg
    18901 taattcaatt cctctagtag gcagggcttc tcgtgctgct cgaagtatgc ttgcagctcg
    18961 cccgcgacgg tgtcgggccg taggccctcg gccagccgat agcgatcgga gtcggtaagg
    19021 ctggtatacc agtgcgccac ctcggtgaga tggattgtgc gcagggcgtt tcgatgctcc
    19081 ggcgtcccga tggcctccag taccgcctgc gcggcggaca gattcgggac ccgctgaagc
    19141 actaccgcct gtggcggccg caggccgttg cggcgcgtgc ccgggccgac ggtgaggagc
    19201 gcggtgcgct cggcggaaat cgtgaaatcg tagccgtgcc ttgccgtccg gaaccataga
    19261 tcccagtcct catacccggc tcgcacggtg gtccaaccgc cgacctcggc cagcagcgtc
    19321 cgcacgtggc cgacacggga cggttcgaac atcgcatggg tggtctgtag ctccggatgc
    19381 cagatcagat cggggatctg agtgcgatcc agctccgtgc ccgtttcgtc gactcggcgg
    19441 caaccggtgg cggcgaaggc ggcaccgcgg tcgagcattc cgagcagagt ctccaaatgc
    19501 gttggtagcc agcgatcgtc atggtcgaga taggccaccg ccggggccgt cgccgccgcg
    19561 gcaccgacgt tgcgtgggcc gccggggtgc ccgtacgggc cggtgcgcag gagccggatc
    19621 cgcggatcgc gatacgcgcg cacgatctcg tcggtgtcgt cggtcgagcc gtccgacacg
    19681 accagcaacg tccaatccgg cacagtctgc gccagcacgc tgtcgatcgt ggcccggatg
    19741 gccgcggacc ggttgaacgt cggacacacg atgtcgattc gagacgaccg ggatgcggac
    19801 aacgactctc catggggcgc gaagggatgt gctccgacca tatccggccg gaactgccag
    19861 ctctgctgac agccacggtc gtgaaccgaa acttggcagt gcgcaacgtt atcggtagac
    19921 ggacacccga aggctggagg aaagcatgat cccgcaggtt cgaggactac tgatgaccgg
    19981 tgcggcgctc tgcggcgccg tggcgatcag cgcgtgcggt ggcggctcgg gtccgaagga
    20041 cccggcccat cgggacggtg tggcactgcc cgagccgacg tcgagcagcc aggctgtcgg
    20101 cagcgagaat ctcggctacc tttggccgtt caccgtcgat cgcggcacga tcgaatgccg
    20161 ggcgggcgag caagcgacgt tcaccgctcc ggatggaaag atctacgcgc tcaacgagaa
    20221 ggccgaacaa tcaggcctac ccggcgtcga gccgttgcgg gcgaccggcg ccggcggcga
    20281 caagatcagt ctcggcgccc tgcgcagccg ggcgatgcag ctgtgtcgct tcgcgaactg
    20341 acctggggag accgaacatg ctgtggcaca gtaggaatgg cactgccgca taaactttga
    20401 accgttgact ctgtggatga tcggtgtcag cgtcgccgca tgaccaagcg cggcacagac
    20461 actcgtcccg acctcgaacg cctcattcac gtcgccgggg cgggcgatga cctgatcgcc
    20521 gagcacatcg agtggatggg cgtcgagcgg accgctcgga cgctcgtccg ggaagtgctc
    20581 gatcgtgtcg atctgcgcgg ttgcccgccg atcgacgtgc tgttccgcct gcatgccggt
    20641 gcgcagtcgg ccgacgtgac cgtgcgcgtg gccgcggacg gcagcaccac gacgccatcc
    20701 gcgccgtcgt ccggtgcggt cgcggccacg gtcgaacagt cactacccga gttcgtccgc
    20761 agtgtgctcg ggccgcgcgg ggcagcgacg agtgccaccc gcgtgctgca ctggcccgat
    20821 ctgtccgcct tcgaaacgtt cggcaggccg caacccgcgt tcgaacccgt tcggcggctg
    20881 ctcgattcga tcgaccacgg ttatcgcgtc acgctcgccg aactgtgcgt ccgcgccggt
    20941 tcggacaagt ggggggtgca tcagtacccg cagcactacg cgaagcactt cgagatgctt
    21001 cgggatcgtc ccctgaccat gttggaaatc ggggtcggtg gttttgccga cccacggcgc
    21061 ggcggcgagt cgctgcgcat gtggaaacgg tactttccgc gggcctcggt gtacggcatc
    21121 gacatcatcg acaagtccga gctgtcggaa ccacggatga cagtgctgcg tgctgaccaa
    21181 tccgcgccgg ccgatctcgc cagggtgctc gagacaaccg ggccgctcga cctggtcatc
    21241 gatgacggca gccacctcag cgcccacgtc atcgcctcgt tcgacgtgct gttccccgct
    21301 ctccggccgg gcggaatgta cgtgatcgag gatctgcaga cgtcctactg gccccatttc
    21361 ggtggcagat ccggtgtcta cgacaacact gcgacgagca tggggttcct caaggccttg
    21421 atcgacggac tcaacttcgc cgagatcgac ggtcgggagc cgaggaggac cgataccgcg
    21481 atcaaaggga tgcacttcta tcacaacatc gtgttcgtcg agaagggcga gaatcgcgac
    21541 gagggagcgc cggcttggct tcgcggggcg tgagctagcg gctgttcggg ttgtagggat
    21601 agtcctgcac ccagtggaaa ttgcggctca gcaagggcag tgaagccaga tcgagccggc
    21661 gcaaccagat ctcggtgcgg tggccgttca gtgtgccgga aagtttcagg ctgtccggtc
    21721 cggcggtatc gacccggagt tcggtgacct gatccggacg gtcgtatcgg ctcaacgcca
    21781 gtcgatggcc agtgacgtcg acggtggctc gatagaaccc gatcgagtcg tccatgcgct
    21841 ggaatttgaa ttcatccggg tactcgaaga acacgcgtcg ccactgcttc tcatcggtga
    21901 tcagcagcgg cacctccttg ccctcctcgg tcgcacgctc cacgttccac accccgtaca
    21961 gtggcggttt cgctcggctg gcaccgtgct cgcgccacgc ggccgcgcag tccccgacga
    22021 tcgggatcgc gatccacaac ccgagtagaa cctgtgcggc aagggcgatc cgagccgccc
    22081 ggtgggcgcg gaagagcggt ggctgagtcg agaggccgac cggcctcctg gacagcagca
    22141 catcgaacag gcggccgagt tccggtgcca gcagcaccag ggtcatcacc aagaggtgca
    22201 gtgacatcga cttgaccgga acgtcgtagg tcaggttgag cacgaagatc tgggtgagac
    22261 cgacggtgcc gagcaccgct ccgagggtgg ttgtccgcgg cagcacgagc agcaggccac
    22321 cgatggcctc gaagctgccg atcatgatct cgtaacccgg cgcggcgccg accgacgacc
    22381 agagcaggcc catgggggtc agctcgccga acggtgacac cagggtggtc agcgggggtg
    22441 acggcatctg tgtcagcagg attttggcga tgccgtagag catgagctgt ccggccaggg
    22501 tgaatcgcag gaacacccgg aaccaggcca gcagcgtcgg atacctggtc cggcgtcgat
    22561 ccagcacgga ccagacgagc gtggccacgg cggcgatgac gagcaggcag aacagcagga
    22621 cccagtcgta ggtgcggtcg ctgctcgccg tcgcggcatg caccaggggt gcacgcacgc
    22681 cgaagatgtg tgcagcggtc cagtccacca acggcgtcat cagcccgctc acgttcaccc
    22741 cggcgctcgg actgctgaag aacccgaaca gcggactgat gagttgggtg agcaccgcat
    22801 agagaccgaa atagctgacg cagaagcgaa aaacgatgcg agtcagcggc cgccatgccg
    22861 taaccgccga ttcctcggcc ggttcgtgct gtggttcggc acgcgtgatc accgacattc
    22921 gacatcaatc cttcgctcgg cccagccgcg ccggtgtgag cggtgcggtc gaaggcgtgg
    22981 acgggtggtc ctcgcggatc ccatcgtgca tcgggaagga cgcgccgcca tcagcctgcg
    23041 cggttgttgg caccccgatg gcaggccgta ctgccatcgg ggtggccggt cgaatcagtc
    23101 ggtcgcggag gcggtttcgg cccacgcgtc gagctcggcg agccgatcgg cgaggacgag
    23161 ccgattgttc gcggtgagct cggcgccgtc gagcatcttc tggaacaggt ggcgatacag
    23221 ctccaccgtc gcacggtcga agtcgtagcg gaacaccgct cgatcgtcga cgccgtgtgc
    23281 cgcctgctcg ataccgttgt tcgcggcgaa ctctgccagg cgagccacct gatctgcggt
    23341 gagtccgttc gggaacagga tctgccattg ttgtgttccg ggctcggtca tgtgcagctc
    23401 ctccctagtc gaagtcgaag aacgtggtat ccgcgtcgta gatctcctcg cgcggatagg
    23461 cgagcgtgcc cagccattcg tcgaatcgct ggactgcgtc ccgaatcggg tcgaggtcgg
    23521 ctgcgctcag cggctcgttg ttcagcgctt tgcgcaagac ctctcggtgc gcgtcgactt
    23581 cggcgcggtc gagtgcaccg gagtgccaga accgcggatc ccggcccgcg cggacgacat
    23641 ccgccgagcc gggatcgcac ataccttccg caacagcgaa atccgcgatg cgcgcgatgt
    23701 tttccttcgt tgtccccggt tcgaaccgta tctgccacgg tccggcagcg gtcggcgcgt
    23761 ctgcggtgtc gttgttcgaa tggtccaaat cagtcaccaa tccggttgag gttcgcgtcg
    23821 taggtcccca tccgggtctt cttcgaggca aggttctccg gcgagctcgc catcttccag
    23881 cgccccccgt tgtggccgtc gacgtcctgt gaaatgtaca ggttcttctt ctcgtgcttg
    23941 aagatcaggc agccatggct cttgccgacg ttggccactg cgtagccgag gtcgcgcgcc
    24001 gcggcccggt cctcggcgtc ggtaaaccgc ttaccggcga cggcttggaa tgcgggtggc
    24061 acgcccgggg tgtccgcgtc gacgacgatc gtcgcggtgg gggccgcggc gctctcggac
    24121 ggtgcggcgg ccgcctgggc actggtcagg gcgaggagtg gcagcgtcgc gaagagcgct
    24181 gcggcaaagg atttgcggat agtgatcaag gttcttccga tcgtctacag ccgagccggc
    24241 ggctcggggc gcacgccgcg ccgacgaggg cgcaagcgtg agtcaggtat tgagtggtag
    24301 tgatgcactg cggcgttgtt ggcgtggcgg tcgactgcca cgccaacgcg cgaagccgcg
    24361 ctagactcgc tcgaccgtga cgatcttggc gtcctcgctg atcgctaccg cgactccgcc
    24421 ccaggtcacc agccaggtgc ggtgctgggg ctgccactgg ccttcgtact tgctgtaaat
    24481 ggcgctctcg
//
