LOCUS       NC_017542              25387 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Paenibacillus polymyxa M1, complete sequence.
ACCESSION   NC_017542
VERSION     NC_017542.1
KEYWORDS    RefSeq; complete genome; complete replicon.
SOURCE      Paenibacillus polymyxa M1
  ORGANISM  Paenibacillus polymyxa M1
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Niu,B., Rueckert,C., Blom,J., Wang,Q. and Borriss,R.
  TITLE     The genome of the plant growth-promoting rhizobacterium
            Paenibacillus polymyxa M-1 contains nine sites dedicated to
            nonribosomal synthesis of lipopeptides and polyketides
  JOURNAL   J Bacteriol 193 (20), 5862-5863 (2011)
   PUBMED   21952539
REFERENCE   2  (bases 1 to 5864546)
  AUTHORS   Blom,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2011) Cebitec, Bielefeld University,
            Universitaetsstr. 25, D-33615, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 01:49:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,687
            CDSs (total)                      :: 5,531
            Genes (coding)                    :: 5,427
            CDSs (with protein)               :: 5,427
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 45 of 104
            Pseudo Genes (incomplete)         :: 71 of 104
            Pseudo Genes (internal stop)      :: 16 of 104
            Pseudo Genes (multiple problems)  :: 23 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:14:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4530518
            Orig. end                         :: 4555905
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE577054.1.
            Accession number for plasmid pPPM1a in this genome project:
            HE577055.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25387
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="16"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..25387
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25387
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15387](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15387)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(187..201)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.2"
                     /tool="antismash"
     misc_feature    473..488
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            1021..2061
                     /locus_tag="PPM_RS20400"
                     /old_locus_tag="PPM_3916"
     CDS             1021..2061
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688423.1"
                     /locus_tag="PPM_RS20400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3916"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_013372700.1"
                     /transl_table=11
                     /translation="MNIKTIASMAGVSVATVSKIINNYTDISEETRQRVLKIMEETGYR
                     PSSSAKTLATKKSNLVGVIFAGKLNVDFSHPFFVDIINVFKKQIGLLGYDLLFFSNEKF
                     LDYGEDYLARSKYFSVDGCIIIAGDEVEKSVFDLDASPIPCIGVDIELTGASSCYIMSD
                     NQKISMKVVEHFYMNGYREMGFIGIERPSLVIKEREEAFIASLKRFSLDFRPEWIVYGK
                     DYAAEDGYQIAKAWIQQGDLPRAVFAATDLLALGAIRAFKESGLRVPEDIAVVGCDDIE
                     ACRYTDPPLTTVKQDKQKIGRLAAMVLFDLMNKQMDTKCIKVEPELVIRTSCGARQNWN
                     HTRIKG"
     gene            complement(2147..3640)
                     /gene="glpK"
                     /locus_tag="PPM_RS20405"
                     /old_locus_tag="PPM_3917"
     CDS             complement(2147..3640)
                     /EC_number="2.7.1.30"
                     /GO_function="GO:0004370 - glycerol kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glpK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818622.1"
                     /locus_tag="PPM_RS20405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3917"
                     /product="glycerol kinase GlpK"
                     /protein_id="WP_013372701.1"
                     /transl_table=11
                     /translation="MGKYILSLDQGTTSSRAILFNSEGDVVYSAQREFPQYFPHPGWVE
                     QNANEIWSSILGVIASCLSESGVKANQIAAIGITNQRESVVVWDKNTGLPVYNVLVWQS
                     RQTADICEELKRQGHEELFHSKTGLLIDPYFSGTKVKWILDHVEGAREKAERGDLLFGT
                     IDSWLIWKLSGGKAHVTDYSNAARTLMYNIYELKWDEELLDILGVPKIMLPEVRPSSEV
                     YAHTVDYHFFGQNVPIAGAAGDQQAALFGQACYEKGMIKNTYGTGCFMLMNTGDQPVES
                     KHGLITTIAWGLEEGKVQYALEGSVFVAGSAIQWLRDGLRMFREAKDSEPYAARVSSTE
                     GVYLVPAFVGLGSPYWDSEVRGAMFGLTRGTTKEHFIRATLESLAYQTKDVLTAMEIDS
                     GITVKMLRVDGGAVLNNFLMQFQSDILDATVERPVIHETTALGAACLAGLAVGYWKSTD
                     ELRKRVRVETSFTPTMDEATRDSLYEGWKKAVNATMAYK"
     gene            complement(3672..4496)
                     /locus_tag="PPM_RS20410"
                     /old_locus_tag="PPM_3918"
     CDS             complement(3672..4496)
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688424.1"
                     /locus_tag="PPM_RS20410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3918"
                     /product="MIP/aquaporin family protein"
                     /protein_id="WP_013372702.1"
                     /transl_table=11
                     /translation="MSPYAAEFIGTMILIALGGGVCAGVSLKKSFAHASGWIVIGMGWG
                     LAVAIAVYAVGQISGAHLNPAVTLALAFQGSFPWQDVPGYIVAQLFGAMAGAVIVILHY
                     WPHWKETEDAATKLSVFATGPAIDHPFANVLSEMIGTFIFVLALLSFGANSFTDGLKPL
                     IVGFLIVSIGLSLGGTTGYAINPVRDFGPRLMHYLLPIPGKGASNWGYAWVPIVGPLLG
                     GSFAGPFYQAVFKGSVTPAFWILLGVIAVVLLITFRISRTYKNHKMNHKLTA"
     misc_feature    4452..4467
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.4"
                     /tool="antismash"
     gene            4814..6295
                     /locus_tag="PPM_RS20415"
                     /old_locus_tag="PPM_3919"
     CDS             4814..6295
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372703.1"
                     /locus_tag="PPM_RS20415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3919"
                     /product="PTS transporter subunit EIIC"
                     /protein_id="WP_013372703.1"
                     /transl_table=11
                     /translation="MLKFLQKIGKSLMLPVATLPAAGILQGLALINYETDIPLGPGVGG
                     FLNHYVTPFLNEGAGAIFGNLALIFSIGVAIGLAGDAVAALSAVIAYLVLTRILAAVPG
                     IFAYIPDDVKLDMGVLGGIFIGGWSAYLFKKYHNIQLPDWLGFFSGKRFVPMITAFTTM
                     ILAILLGMIWSPIQDGIAAFGNWIVGFGGIGSMVFMIANRLLIPLGLHHVLNSIAWFQI
                     GDYTNAAGEVVHGDLTRFFAGDTSAGMFMSGFFPIMMFALPAAALAFIHTAKPEKRKAV
                     ASIFIGSALASFLTGITEPLEFSFMFIAPLLYGVHALLTGLSGLVVYLLDVKLGFSFSA
                     GLIDYLVNMKLSTHPLRMIPIGLVFAFVYYFLFRFIILKFNLKTPGREDDVDDNLLSEA
                     NESIPHGKASTLSDIQSSHADKVLTYLGGSDNIQSIDACITRLRLVVKDDKVVNDQALK
                     KLGASGIIRLGNGTLQVIFGTRSETLKDEIQRLMS"
     gene            6493..7776
                     /locus_tag="PPM_RS20420"
                     /old_locus_tag="PPM_3920"
     CDS             6493..7776
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /function="ABC-type sugar transport system, periplasmic
                     component"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277625.1"
                     /locus_tag="PPM_RS20420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3920"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_016324661.1"
                     /transl_table=11
                     /translation="MKTVQWLILCLAFLTMISGCSGSLSSEGQPSETNLSNGKKITLTL
                     WYWNRSIDDELLAQAEKQFPDIELKTQKIGGDFKAKLKTTLAARSGEPDIVALNDWMVE
                     LFPSADRFYDLRELGADRLKDQYLEWKWNQGITPDGKMIAFPMDTGPTALFYRSDLFEQ
                     AGLPSDPEQVSSSIRTWDDYMAAGEQLRQKFGSRSFLADNIVNVYNQVLAQHTNLYFKP
                     DGSYVGNQSPDIRLGWKTAVDFHRKHLLANADGWTPEWNASVNNGKIASFVGAIWMKQV
                     LTEAAPDTAGKWRVARAPGGDGNLGGSFISILKSSQHPKEAFEVLTWLQNPEHQLEAYH
                     KIGLFPSTPGVYDDPVMETPEPFFGGQATGLIFAASARHVKSSYFGERYPVIHGIVTRR
                     LSNVAKQDADPDALWSETMQRIERELQR"
     gene            7809..8684
                     /locus_tag="PPM_RS20425"
                     /old_locus_tag="PPM_3921"
     CDS             7809..8684
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277626.1"
                     /locus_tag="PPM_RS20425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3921"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_013372705.1"
                     /transl_table=11
                     /translation="MLREIWKHRAVYAAISPFYLLFAIFGLFPIGFSLYLAFHKWDGIG
                     DMTYNGWGNFRYLVTDTEFWQAVGNTFVIWVYATIPMLLLALIVAFLLYAPFVKLRTLW
                     RVGFFLPNVTSIVAVAIIFGALFANNFGFLNYLLQLLGLPMIQWLNVPWGIQIAISSMV
                     VWRWMGYNAIIYLAGLQSIPHVLYEAAKIDGATGAQAFFRITIPMLRPVILFTVITSTI
                     GGMQLFTEPQVLVGNDGGSGASGMTIVLYLYRESFINNYFGYGAAVGWGMFLIIAVFSI
                     INWKLVQGKK"
     gene            8706..9533
                     /locus_tag="PPM_RS20430"
                     /old_locus_tag="PPM_3922"
     CDS             8706..9533
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372706.1"
                     /locus_tag="PPM_RS20430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3922"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_013372706.1"
                     /transl_table=11
                     /translation="MMQTRAKSIVLYAGLLVGIILSMFPFYWLIVMATRTTSDIYRFPP
                     QLWFGSHFLDNITRVLQQIDFAGAFFNTLFVASSVTVLVLFFDSLAGFAFAKFDFPGKK
                     GLFVILLATMMVPSQLSLVPSFVMMASFGWVGTFKALIIPGMVNAFGIFWIRQYAEESI
                     PKELLDAGRMDGCSFFRLYWNVALPILRPAFAFLGAFTFIGAWNDYLWPLIVLTDERKF
                     TLQIALSQLNGIYNTDYAMVIAGTLLAVLPLIILFLFISRQFISDLAAGAIKD"
     gene            complement(9771..9965)
                     /locus_tag="PPM_RS29345"
     CDS             complement(9771..9965)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPM_RS29345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148266409.1"
                     /transl_table=11
                     /translation="MRIVNPFGKKPLMANSLGIVPLSCICSSGSNNILHDFGHGSNCAC
                     KCRPDRQMNSSANYDMALS"
     gene            complement(10001..11533)
                     /locus_tag="PPM_RS20435"
                     /old_locus_tag="PPM_3923"
     CDS             complement(10001..11533)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372709.1"
                     /locus_tag="PPM_RS20435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3923"
                     /product="radical SAM protein"
                     /protein_id="WP_013372709.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.9e-07, bitscore: 29.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.4e-47, bitscore:
                     160.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.4e-11, bitscore: 43.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.9e-06, bitscore: 24.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILDSTVMEFFRNIEKQYGNYSRLFKLFQTKNKSYLYDVGTGKVM
                     ECNEIEYTFLNNLQLYGDIAKVINPIKVNDDTLTILIDLIHVAHEQHLFQAPPLLSFAL
                     SEDEVLKNAKSHLEQVTLELTEQCNMACHYCIYHSGNIDFREFGRRHMSWQVAELAIDY
                     TLKNSGKKVAVTFYGGEPLIEFKLLKHCVAYALENGAGKDLTFSMTTNLTLMTAEIAEY
                     LSTIPNFGVVCSIDGPKEIHDCRRVFKNGAGTYDKAIHGLKYLINAYGEKSNSLISLSM
                     VTPRPTNDAVMKKIQNFFNSLSWVPKDITKNISYVRHSSDIEKTITEENPIHCYDNPVG
                     NWTTDLMLNNTYTSQSNPFTIDFLHKQFSIIHDRILTETPYPNYNLNGCCSPATRRIYV
                     TANGDFHLCERIGKSPSVGNVYSGLDETVLIDRYIEDYCKESLPQCSECWAIRLCSVCY
                     VECYDSDKFNIEKKRMACRRSLDMLEHALISYHTILENKPHLLEALNHITLV"
     aSDomain        complement(11348..11518)
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PPM_RS20435_Other_Sactipeptide_rSAM_R
                     RE.1"
                     /evalue="1.00E-09"
                     /identifier="RREFam021.1"
                     /label="PPM_RS20435"
                     /locus_tag="PPM_RS20435"
                     /protein_end="62"
                     /protein_start="5"
                     /score="29.4"
                     /tool="antismash"
                     /translation="TVMEFFRNIEKQYGNYSRLFKLFQTKNKSYLYDVGTGKVMECNEI
                     EYTFLNNLQLYG"
     gene            complement(11499..13172)
                     /locus_tag="PPM_RS20440"
                     /old_locus_tag="PPM_3924"
     CDS             complement(11499..13172)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818615.1"
                     /locus_tag="PPM_RS20440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3924"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013372710.1"
                     /transl_table=11
                     /translation="MIVLEYLKKYLSKTRKYVFFYIAVTSVLWIIGIIVPYITGIYIDY
                     LVSKSNISIILYFVLLLGIINIANILIQYLTALFSTKLNNLLLYEICNDIYQKIFKTKL
                     SVFKDKDNAYLVDQINNDSSTVVDFFSNNISNLVLQVITIIVSGIIVLKADVLLCVIIF
                     SLIPFYIFTYVVFRKKLYKANLKYKKEANEYYSKKVEQINKLVFIKKNVLFNEMNERLN
                     KAFNSLFRVATSQVKTNYIFSNLNQFILIICYIFVIGIGGHKVVIGQMSVGQFTIINTY
                     LSMIISSTSYLLSLASSYQETKVSIERLNDIMKSENDIYGSATLVELEKISIKKLGVKY
                     SGESVFRDFSYDFSKGEIYGICGHNGSGKTTLLNTMIGLYSDLYTGEIAFNNCSIKDLD
                     MLNMRRFKISYVEQNPEFLNLPIEEYLRFGINFSKETASNQNELINAFGLEGMITKSNL
                     ENILINENGSNFSGGEKQKLSLIRALSKDSFLTILDEPTSALDSKSVSGLVEILTKQKS
                     RKITIVVSHDQRLLAACDHILNIEIQKERDDIGFHSYGVL"
     gene            complement(13418..14065)
                     /locus_tag="PPM_RS20445"
                     /old_locus_tag="PPM_3925"
     CDS             complement(13418..14065)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818614.1"
                     /locus_tag="PPM_RS20445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3925"
                     /product="hypothetical protein"
                     /protein_id="WP_013372711.1"
                     /transl_table=11
                     /translation="MLMLKKMCIVLCGFLLMGMPLGSSSNAASNDVKNINLTAINCNVT
                     VTKTSASDFSYEYNKSLYTVTSTLSGYTIYITVKGKGSVNGISDRVNILIPEKSYEKIT
                     VESTKAGVSLPELNTNLDITGVDGSSMSVRVPVGYSKAINYDNTKGSGSLTFSKGASDY
                     TVTVKTTASALSVPAGWPLFRPNLTYNYINGAGKAKINITLENSAFSIAAQK"
     gene            complement(14059..15387)
                     /locus_tag="PPM_RS20450"
                     /old_locus_tag="PPM_3926"
     CDS             complement(14059..15387)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372712.1"
                     /locus_tag="PPM_RS20450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3926"
                     /product="radical SAM protein"
                     /protein_id="WP_013372712.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.6e-38, bitscore:
                     130.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.4e-14, bitscore: 52.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.1e-10, bitscore: 38.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.3e-15, bitscore:
                     53.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKASQYNFIFNDIIENTDKTVLYNSRTGALAVLEPEYYKQFCELT
                     NNGLAINNDTYLKNLIECGYIVEDNMNEKAYVKVNLLKNRFESSNLMLTIAPTMACNFR
                     CVYCFEKDQYHNKTMSEETAQSIVNFVKTNASKLDTLNVTWYGGEPLIAMKQIVRISED
                     FLEICKENNIQYTASVITNGYLLNKEKVQTLISCGVNDIQVTVDGPKEVHDLRRPLVSG
                     RGTFDVIMNNLKQIKGMIKIFMRINTDQDNWLNLHEIVGFLKENSLLENVIPYLGLVTP
                     TNGKYEGTKCLTDEMYSKFNLKFMSENDIPISYIYPAPKGNYCSADKYNSFVIDPLGHL
                     YKCWSDIGIIEQCVGIINEDTSVKWNTELLGCYLLYDPTEDEKCSDCKYLPVCLGGCPH
                     NRMADFNICEQYRYNLQEYITECTKVLLAGQLTENKKEVSESC"
     misc_feature    complement(15445..15460)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(15496..15508)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    15643..15658
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.16"
                     /tool="antismash"
     misc_feature    15689..15706
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.33"
                     /tool="antismash"
     misc_feature    15965..15980
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.97"
                     /tool="antismash"
     misc_feature    15967..15981
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.91"
                     /tool="antismash"
     misc_feature    15975..15990
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            16047..16802
                     /locus_tag="PPM_RS20455"
                     /old_locus_tag="PPM_3927"
     CDS             16047..16802
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818612.1"
                     /locus_tag="PPM_RS20455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3927"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_228392871.1"
                     /transl_table=11
                     /translation="MVYLFQVAVCDDDPAMHKILQHFFMCMSVSESLDFNLQFFLSGED
                     LIKSYSSQERYSFHIILLDIEMRELSGIETAKLIRLFPDREVQIIFLTNYPEYMLESFE
                     VQAFQYLLKPLTYKLFVEKINKLCHYMRSSVSHFLSVKNKTEHLVLRHSEIIAISKGEN
                     NYIHNELCIATDSHNYFISGTLKAVYEQLKYPFVFIHRSIIVNLVHIRKFSTTSVIMSN
                     QQEFPVGRSHAKSLREAYARFIISRFQEG"
     misc_feature    16965..16978
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.6"
                     /tool="antismash"
     gene            17120..17821
                     /locus_tag="PPM_RS20460"
                     /old_locus_tag="PPM_3928"
     CDS             17120..17821
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372715.1"
                     /locus_tag="PPM_RS20460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3928"
                     /product="ATP-binding protein"
                     /protein_id="WP_228392872.1"
                     /transl_table=11
                     /translation="MNVIIVFLMDKLIEKSNLSRFFQKQMLMQEKHYKETTRSLSDIKR
                     SIHDFKKQLIFVRACLQEQRTEEGVNHINQTLENIESPRLHITTGHLVIDALVNHTFSI
                     ADKSGIAFFHQIHINPANISIGSHDLCIVLGNVFDNAIEAVRQLPRKKEHSIHLEILTD
                     NSALWIYVRNSKSNCLNTAFSTKTYTPPLKKHGYGLLNIHQVIKKYGGYLNTTITDSNF
                     QITIMIPCNNP"
     gene            complement(17947..19365)
                     /locus_tag="PPM_RS20465"
                     /old_locus_tag="PPM_3929"
     CDS             complement(17947..19365)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005283 - amino acid:sodium symporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /function="Na+/alanine symporter"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1153: Amino acid carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431746.1"
                     /locus_tag="PPM_RS20465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3929"
                     /product="sodium:alanine symporter family protein"
                     /protein_id="WP_016324662.1"
                     /transl_table=11
                     /translation="MNLVHLLETIDSWMWGAPLLILVMGTGLWLTIRLKMLQIIRLPLA
                     LKLIGKAPDEGSGDVSSFGALSTALAATVGTGSIVGVATAIKLGGPGSLFWMLVAAFFG
                     MATKYAEGLLSVKYRVKDRNGQFSGGPMYYIENGLGRRFKPLAMLFAFSGILVALFGIG
                     TFPQVKAIVSSTESSFGVPTVVTAIIISVLTAVVTIGGLKSIAKVSTKIVPFMSGLYIV
                     VCLIVLIKFAGELPHAIALVLQGAFSTTSATGGFAGATIMLAMRSGVARGIFANEAGLG
                     SAPIAAAAAKTKWPAEQGLISMTGVFIDTMIICNLTGFTLLVTGIWSGNDDGGLMTQHA
                     FSSAFPAGAELVTISLILFAFTTILGWNYYGERCVEYLLGVKWIKPYRYLFIILVAGGA
                     FIKLDAIWLLADIFNAMMAFPNLIALLGLSGIVVAETRTYMNSLYPNKKKGILAGANVG
                     AAIQVEEKGQTINS"
     regulatory      complement(19512..19607)
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    19672..19686
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 21.6"
                     /tool="antismash"
     misc_feature    complement(19757..19772)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.74"
                     /tool="antismash"
     gene            complement(19871..21328)
                     /locus_tag="PPM_RS20470"
                     /old_locus_tag="PPM_3930"
     CDS             complement(19871..21328)
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010348049.1"
                     /locus_tag="PPM_RS20470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3930"
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="WP_013372717.1"
                     /transl_table=11
                     /translation="MTKTLKGFPQNFLWGGATAANQLEGAFDVDGKGLSSADMIAYVPK
                     AERKNDHAIEISSERLEDILAGKVNARFPKREGVDFYHRYKEDIALFAEMGFKVFRMSI
                     HWSRIFPNGYDAEPNEAGLQFYDNVFDELRKYGIEPLVTLSHYETPLGLTQKYNGWLGR
                     EVVDHYVKYAETVFTRYKDKVKYWLTFNEINVMTMSPFTGGGVVIDRVENKQQAIYQAL
                     HHQFVASALATKRGHEIIPGAQIGCMLARIESYPHTCNPEDILKAQHENQMNLFFTDVH
                     ARGEYPNYMNRYFEENNIVIQTEPGDAEILKNNTVDFISFSYYMTLTVSAGPEGEKAAG
                     NLIGGVKNPYLQSSDWGWQIDPIGLRVTLNTFYDRYQKPLFIVENGLGAYDKVEEDGSV
                     HDTYRIDYLRQHIAQMKEAIADGVDLIGYTSWGPIDLVSMSTSEMSKRYGFIYVDLDDD
                     GNGTLQRSKKDSFNWYKNVIATNGEEL"
     misc_feature    21392..21407
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.11"
                     /tool="antismash"
     gene            21538..22509
                     /locus_tag="PPM_RS20475"
                     /old_locus_tag="PPM_3931"
     CDS             21538..22509
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431750.1"
                     /locus_tag="PPM_RS20475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3931"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_013372718.1"
                     /transl_table=11
                     /translation="MSNLDQIAKLAGFSKATVSRVLNQSPHVSHETRTKILKIMQELDY
                     VPNRNAISLSKGQTLQIGIITSTINEIVLAFLDSFVEIAGQYEFQTIIYTSGEDKKKEL
                     QAFEDLKRKRVDALVIISCVNDTDFLSTYCKYGPIVAWQRMEHTDIRSVAMDQYEGYML
                     ALKHLIQKGYTRIANAFGRPSSINTHSRQRAYEQIMSEHNLPVLQHWNYSSIYNIRDGE
                     QVVRNLLQHREEFPEAILCANDYVAVGILCEARRQLLKVPEDLAIIGFDNTELAHTMGI
                     TTVQNPIMAQAQNAFFMLSPQLIGRQMELHSLEYSLIERTTT"
     gene            22744..23592
                     /locus_tag="PPM_RS20480"
                     /old_locus_tag="PPM_3932"
     CDS             22744..23592
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818607.1"
                     /locus_tag="PPM_RS20480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_3932"
                     /product="PRD domain-containing protein"
                     /protein_id="WP_013372719.1"
                     /transl_table=11
                     /translation="MIIEKVLNNNVLLTKNDKGKEVIVMGRGISFKKVAGDPVDDHKID
                     KIFMLNENEFTARLTELLNDIPVSHLEVVNEIVTHAAEVLDTELSDNIYLTLTDHIHFA
                     IQREEKGLALKNAMLYEIKRFYKKEFAVGLDALQKIENTLGVKLGEDEAGFIALHMVNA
                     RIDGNEMKATLKMTEIVQHILNIITYHYGIVLDESSFSYSRFLTHLQYFAMRVIRKEVI
                     HSGEEFLYNQVKQTYTEAFACTQKINEYLEKTYDQYLSKDEYVYLTIHIHRVTERNNIS
                     G"
     misc_feature    complement(23630..23648)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
ORIGIN
        1 ccaattttac ctgttaatcc tttttcctta tgcaaattga tcgcaatccc atgacacatc
       61 aaaatatgat gggcagcagt aaaggcttcg ctccagttct catgcccagg ggcatgctcc
      121 cctgtaccat atcccaaaat agaagcgcaa taaggctcgt ttatcgtatt ccaccagtta
      181 attcgctggc caaatcggtc catgattaca gaggcatacg ttttaaaatg ttggataatc
      241 tctcgctgcg tccatccacc ttcgtcctca atccactgcg gtaaatccca gtgatacaga
      301 gtcagcattg gaattagccc ggccgactca agctcatcca gcagatgctc atagaagagc
      361 agcccttgtt cgttgaccac gccgggcgcg ggcataatgc gcggccaagc cacagaaaaa
      421 cgataatgta aaaaaccaag ctgtttcatt aattgcacgt cttctttaaa gcggtgaaaa
      481 tggtcacaag ccacatctcc acaatcccct tcgatcacct tcccgggaat ttgacagaaa
      541 gtatcccaaa tggagggcgt tctaccgccc tcatttgtgc caccttcaat ttgataggaa
      601 gaggttgaag ttccccacat aaacgtatca ggaaatacaa agatattctc gctcatactc
      661 ggtaccttcc tttcagaaat aaagacttca cagctccggc cattgcaccg ccgacaataa
      721 agcgctggag gaaaatatgc aaaataacca gtggtaaatg cattcacttt tacgaaagcg
      781 gtttagttaa ttgcagctac tattatgtat cgaataacct gtatttgtaa atagagaatt
      841 atgaaatatc aaaaaaatat aatcaccgtt aaattatcgt tgttactcct taaaatatta
      901 ggataaatcc tttattaact ctgttgactc ccatctatga ggtagcatag aatacgagta
      961 atcattgaat ttgaaataca aagtcaattt aactaaatca gtttagttgt ggaggattcc
     1021 atgaatataa aaacaatagc tagtatggca ggcgtttcag tagcgacggt ttcgaaaatc
     1081 ataaacaatt acacagatat cagtgaggaa acccggcagc gagtacttaa aattatggag
     1141 gaaacaggct atagaccttc ctcctcggct aaaacacttg ctaccaaaaa atccaatctg
     1201 gtaggcgtta tattcgctgg caagctgaat gtcgatttta gtcatccttt ttttgtggac
     1261 atcattaatg ttttcaaaaa gcagattggc ttgctcggtt atgacctgct gtttttttca
     1321 aatgaaaaat ttctggatta tggagaggac tatttggctc gctcgaaata tttttcagtg
     1381 gacgggtgca ttattattgc tggagacgaa gtggagaaaa gtgttttcga tctcgacgcc
     1441 agtcctatcc cctgcatcgg tgtcgatatt gagctaaccg gagccagttc ctgctacatt
     1501 atgtccgaca atcaaaagat ctcaatgaag gttgttgagc acttttacat gaatggatac
     1561 cgcgagatgg gttttatagg cattgaacgc ccctccttgg ttattaaaga gagagaggaa
     1621 gcgtttatcg cttcactaaa gcggtttagc cttgatttca gacctgaatg gatcgtgtat
     1681 ggtaaggact atgcggcaga ggatggatac cagattgcga aggcgtggat acagcaagga
     1741 gatttaccaa gagctgtttt tgcggctacc gacctgcttg cccttggtgc catccgtgct
     1801 tttaaggaaa gcggcttgag ggtacccgag gatattgctg tagtaggctg tgatgatatt
     1861 gaagcctgtc gttataccga tcctccattg acgactgtaa aacaagacaa gcaaaaaata
     1921 ggtcgtctag ccgccatggt gctgtttgac ctgatgaata aacaaatgga tacgaaatgt
     1981 attaaagtag agcccgaact agtcattcgt acctcttgcg gagcccggca aaattggaac
     2041 catacgagga tcaagggata gcatatacct caaaaaggtg actcctgttg aattcagaag
     2101 tcaccttttt acagtttaaa tatatagagc ctcttcgttt aagctattac ttataggcca
     2161 tcgttgcatt cacggccttt ttccagcctt catacaggct gtcacgtgtt gcttcatcca
     2221 tcgtaggggt aaaggaagtt tccaccctca ctcgcttacg aagttcatct gtactcttcc
     2281 agtatccaac cgccaagcct gccagacatg cggcacccag cgctgttgtc tcatggatga
     2341 ccggccgttc caccgtcgca tccagaatat cgctctggaa ttgcatcaga aaattgttca
     2401 acacagctcc accatccact cgcaacatct tcaccgtaat acctgagtca atctccatgg
     2461 ctgtaagcac atccttggtc tgataagcga gcgactccaa ggtggcgcgg ataaaatgct
     2521 cttttgtggt tccccgcgtc agaccgaaca tcgctccacg cacctcgcta tcccagtagg
     2581 ggctgcctag tccgacaaaa gcgggtacaa gatacacccc ttctgtagag gaaacacggg
     2641 ccgcataagg ctcactgtcc ttcgcctcac ggaacatgcg cagcccgtct cgcagccact
     2701 ggatcgccga gcccgcaaca aacacactcc cctcaagtgc gtattgcact ttgccttcct
     2761 ccagtcccca agcgatggtc gtgatcagac cgtgcttgga ttcaacaggc tgatcccccg
     2821 tattcatcag cataaagcag cctgtgccgt aagtgttttt gatcattcct ttttcataac
     2881 aagcctgacc gaacaaggct gcctgctggt cacctgctgc accagcgatc ggtacattct
     2941 gaccaaaaaa atgataatcc acggtgtgcg catatacctc ggaagagggc cttacctcag
     3001 gcagcatgat ttttggaaca cccagaatgt ccagcagctc ttcatcccac ttgagctcat
     3061 aaatattgta catcagcgtt ctggccgcat tggagtagtc tgttacatga gcctttccac
     3121 cggatagttt ccagattagc cacgagtcaa tcgtaccgaa taacaagtca cctcgttccg
     3181 ccttttcacg cgcgccttct acatgatcca gtatccactt tactttagtg cctgaaaaat
     3241 acgggtcgat caataaccct gttttgctgt gaaacaactc ctcatgccct tgccgcttca
     3301 attcttcgca aatatccgcg gtttggcgtg attgccatac gagtacgtta tacacgggta
     3361 atcctgtatt tttgtcccac acgaccaccg attcacgctg attggtaatg cctatggcag
     3421 caatttggtt agcttttaca cccgattcgg aaagacagga ggcaataacg cccagaatag
     3481 agctccatat ttcattcgca ttctgctcta cccagccagg gtgaggaaaa tattgcggaa
     3541 attcccgctg ggccgagtac accacatctc cttcgctatt gaacaaaatc gctcttgaac
     3601 ttgtcgttcc ctggtctagt gacaaaatat attttcccat gttcatctct ccccgtgtaa
     3661 atccatcgtt tttacgctgt aagcttatga ttcattttat gatttttata agtgcgactg
     3721 atacggaagg taatcaagag taccaccgcg atgaccccta ataaaatcca gaaagccgga
     3781 gtcacacttc ccttaaaaac ggcctgataa aatggccctg cgaaagatcc ccccaatagc
     3841 ggtcctacaa tgggcaccca tgcgtatccc cagttggatg ctcccttccc gggaatcggt
     3901 agcaaataat gcatcagacg cggtccaaaa tccctcactg gattgatggc ataacccgtt
     3961 gtacctccaa gggataaacc gatactgaca atcaaaaaac caacaatcag cggtttcaga
     4021 ccgtctgtaa atgaattggc accaaacgac agtaaggcaa ggacaaagat aaaagtacct
     4081 atcatttcac taagcacgtt ggcaaacgga tgatcaatag ctggtcctgt cgcaaataca
     4141 ctgagtttgg ttgctgcgtc ctccgtctct ttccagtggg gccaataatg caaaatgacg
     4201 atcactgcac ccgccatggc cccaaaaagc tgggccacaa tatagccggg aacatcctgc
     4261 catggaaaac taccctgaaa tgccaacgcg agtgtaactg ccggattcaa atgcgctccg
     4321 ctgatttgac ccaccgcata caccgcaata gctaccgcga gcccccaccc cattccgatc
     4381 acaatccagc cggaagcgtg agcaaatgac tttttcaggg acacccctgc gcacactccg
     4441 ccacctaggg caataagaat cattgtccct atgaattcgg ctgcgtatgg cgacatacaa
     4501 ccaacctcct caatagatcc tccgattttg atcgttttca tcgcgcaaaa aaagaaaagc
     4561 catcacaaac caaccctgtg ctgtaccatg ggatgtctgc gtggctctct cgtctccgtc
     4621 acgattatta acttaaattt gatattatat aagcatgtaa gcgatgtcaa ctacggattt
     4681 acgtcttttt gtattctaaa ataatcgttg accatgttag attgcgcgat ttatgatgta
     4741 aaaaaatggc tggacgtaag gatttcagga tgaatacgac actcccaaac ttgatgaaga
     4801 agggaagaat gttatgctga aatttctaca aaaaatcggc aagtcgttaa tgcttccagt
     4861 agctacttta cccgccgcag ggatcttgca agggctagct ctcattaatt atgaaacgga
     4921 cattccgctt ggtcctggag tcggtggatt tctgaatcat tatgtcactc cttttctgaa
     4981 cgaaggagcg ggtgccatct tcggcaacct ggcgctcatt ttctccatcg gtgttgccat
     5041 tggcctggca ggcgacgcgg tagccgcact ttcggcagtc attgcctact tggtgctgac
     5101 ccgtattttg gcggccgtac cgggtatatt tgcgtatatt ccagacgacg tcaagctgga
     5161 catgggcgta ttgggtggta tttttatcgg cggatggtct gcttacctgt ttaaaaaata
     5221 tcacaatatt cagcttccag attggcttgg ctttttttcg ggcaaacgtt ttgtccccat
     5281 gattaccgcc ttcacgacca tgattctagc cattctgctc ggcatgatct ggagtccgat
     5341 acaagatgga attgcagcct tcggcaactg gattgtcggc tttggcggaa tcggctcaat
     5401 ggtgttcatg attgccaatc ggctgctgat cccgctcggt ttgcatcatg tgttgaactc
     5461 gatcgcatgg tttcaaattg gtgactatac caatgctgca ggtgaagttg ttcatggtga
     5521 tctgacgcgt ttttttgcag gtgatacatc ggcaggtatg ttcatgtccg gcttcttccc
     5581 cattatgatg ttcgctctgc cggcagcggc tctcgcattc atccatacgg ccaaaccgga
     5641 aaaacgtaaa gctgtcgctt ccatctttat tggttctgcg ctagcgtcgt tcctgaccgg
     5701 aattactgag cccctcgaat tttcgtttat gttcattgca ccattgcttt acggcgttca
     5761 tgctctgctg acagggctga gcggtctggt cgtataccta ttggatgtca aactcggctt
     5821 ttctttttca gcaggtctca ttgactatct ggtcaatatg aagctctcca ctcacccttt
     5881 gcgaatgatc ccgatcgggc ttgtcttcgc cttcgtgtat tattttctat tccgcttcat
     5941 cattctcaaa ttcaacctaa agactcccgg gcgtgaagac gatgtagatg acaatctcct
     6001 atctgaggct aacgaatcca taccccacgg aaaggcaagc accctatccg acattcagtc
     6061 cagtcatgca gacaaggtcc taacctatct cggcggttca gacaacatcc aaagcattga
     6121 tgcctgtatc acacggctac gccttgtcgt caaagacgac aaagtggtta acgatcaagc
     6181 tcttaagaag ctcggagctt caggaattat caggcttggg aacggtaccc tgcaggttat
     6241 tttcggtact cggtccgaaa ctctgaaaga tgagatacaa cgattgatgt catgaagcta
     6301 atcccctgac ttaaacacgt gcgatcttcc tataacagac gcacgtgctt ttttttatgg
     6361 ataaacgttt caaatttttt gtttttggtt aaggcaatgc acataaatgg gtaacagctt
     6421 catatgatgg agctaaacca tttacaactt gttcagtagg cagattattc agatagcaag
     6481 gagggaaatg atgtgaagac agtacaatgg ctgatattat gtcttgcttt tctcactatg
     6541 attagtggtt gtagtgggtc cctgtcctct gaaggccaac catctgaaac taatttgtca
     6601 aacggaaaaa agataacgct tacattatgg tattggaatc gttctattga tgatgaattg
     6661 ctcgcccagg cggaaaaaca gttccccgac attgaattaa aaactcaaaa aataggcggt
     6721 gactttaaag ccaaactgaa gacaacgctc gcagctcgtt ccggtgaacc agacatcgta
     6781 gctctgaacg actggatggt ggagctgttc cccagtgcag atcgttttta tgatttaagg
     6841 gaactcggag cagatcgcct gaaggatcaa tatttggaat ggaaatggaa tcaggggatc
     6901 actcctgatg gtaaaatgat tgcatttcct atggatactg gacccaccgc cctcttctat
     6961 cgtagcgacc tgtttgaaca ggcgggctta cctagtgatc ctgaacaggt cagttcctct
     7021 atccgtacat gggatgatta catggcagcc ggagaacaac ttcgtcagaa attcggaagt
     7081 cgttcgtttt tggctgataa tattgtaaac gtttacaatc aagtgcttgc tcagcatacg
     7141 aacctatact tcaagccgga cggaagttat gtcggcaatc aatctcctga catccgccta
     7201 ggctggaaaa ccgctgtgga tttccatagg aagcatctgc tcgccaatgc ggatggctgg
     7261 actcccgaat ggaacgcttc ggtcaataac ggtaaaatcg cctcgttcgt aggggcaatc
     7321 tggatgaagc aagttctcac agaggctgca ccggatacag caggcaaatg gagagtcgct
     7381 cgggctcctg gaggagacgg caatctggga ggttctttca tctctatcct caaatccagc
     7441 caacacccca aagaagcctt tgaagtcctg acctggctgc aaaacccgga acaccaactg
     7501 gaagcctacc acaaaatcgg gctgttccca tccactcccg gcgtctatga cgatccagtc
     7561 atggagacac ccgagccttt ctttggtggt caggccactg gtctcatttt tgccgcctcc
     7621 gcgcgtcatg tgaaaagcag ctatttcggc gagcgctatc ctgtcatcca tggcatagtg
     7681 acccgccgtc tttccaatgt ggccaaacaa gatgccgatc ccgacgcatt atggtcggaa
     7741 acgatgcaac gaattgaacg ggaattacag cggtaaaaaa caaaatccaa aaaaggcgtg
     7801 tggacaatat gctgagagaa atctggaagc accgggccgt atatgctgcg atctcgccat
     7861 tttatctgct gtttgccatc tttggcttgt ttccgattgg cttttcattg tacctggcgt
     7921 ttcacaaatg ggacgggatc ggagacatga cctataacgg ttggggtaac tttcgttacc
     7981 ttgtgacaga caccgaattt tggcaggctg taggcaatac gtttgtgatc tgggtgtatg
     8041 ccacgattcc aatgctactt ctagccctta ttgttgcctt tctgctttat gccccttttg
     8101 tgaaattgcg caccttatgg cgagttggat tcttcctgcc caatgtgacg tctattgttg
     8161 ctgttgccat catcttcggc gccttatttg ccaacaattt tggatttctc aactatcttc
     8221 tgcagctttt ggggctacct atgatccaat ggctcaatgt gccgtggggt atccaaatcg
     8281 ccatttcttc catggtcgtc tggagatgga tgggctacaa cgccatcatc tatctggctg
     8341 gactccagag tattccgcat gtgctgtatg aggccgccaa aatagacggc gcaaccggag
     8401 cacaggcttt tttccgcatc accattccca tgttgcgtcc agtcattttg tttacggtca
     8461 ttacgtccac catcggcggt atgcagctct tcactgagcc acaggttctg gtcggtaatg
     8521 acggcggttc cggggcaagt ggcatgacca tcgttttata cctgtaccgc gagtcgttca
     8581 tcaacaacta ttttggatat ggtgctgccg tcggatgggg tatgtttctc atcattgccg
     8641 tattctccat catcaattgg aaactcgttc aaggtaaaaa ataacgatgg aaggagcgtc
     8701 acaacatgat gcagacacgt gcaaaatcca ttgttctata tgccgggctg ttggtgggta
     8761 tcatcctgtc gatgtttccg ttttactggc tgatcgtcat ggcgacccgt acaacctcag
     8821 acatctatcg ttttccgcca caattgtggt tcggtagcca cttcctggat aacataacga
     8881 gagtattgca gcagattgat tttgctggag ctttttttaa tacccttttt gtagccagtt
     8941 ctgttaccgt attggtgctg ttttttgatt cactggctgg ttttgcattc gccaagtttg
     9001 attttccggg caaaaagggg ctattcgtca tactgcttgc aacaatgatg gtcccttcac
     9061 aactttcgct cgtcccctcc tttgtcatga tggcttcctt tggatgggta ggtacgttca
     9121 aagcgctcat catcccaggt atggtaaatg ctttcggtat tttctggatc cgccagtatg
     9181 cagaagaatc cattcccaaa gagttgctgg atgcggggcg tatggacggg tgcagctttt
     9241 ttcggctgta ctggaatgta gcactgccga ttttaagacc tgcgttcgct tttctcggcg
     9301 catttacctt tataggagct tggaatgatt acttatggcc gttaatcgtt ttaacggatg
     9361 agcgcaaatt tacgctccag attgcattgt cccagttgaa cgggatttac aatacggact
     9421 atgcgatggt cattgctggc accctgctgg ctgtactccc tcttattatt ttgtttcttt
     9481 ttatcagccg ccagtttatt tccgatcttg ccgctggagc gatcaaagat tagcttcact
     9541 tgattcccat ctggaaatat tgccctaaat ggaacactgc aaatgagtta cttcgaagac
     9601 tgagcttcgc atacgattga atatgcaccg tctgcctgtg atccatattc ccctgcaaac
     9661 ttgtttccat atttttgtaa tgattaataa aaaatcgctt ccactcatct aactgagtag
     9721 aagcgatttt ttcaaaattg atattctaca aacgttgatc ctttaataga tcaactcaaa
     9781 gccatatcat agtttgcact actattcatt tgtctatcag ggcgacattt acatgcacaa
     9841 ttcgagccat gtccaaaatc atgaagtatg ttattactac cggaagaaca tatgcaagat
     9901 aaaggaacaa ttccaagact atttgccatt aaaggcttct ttccaaatgg atttacaatt
     9961 ctcatttata atcctccttc aactctactt tgtttataga ttacaccaaa gtaatatgat
    10021 ttaatgcttc taataaatgt ggtttgtttt ccaagatagt atgatagctt atcaatgcat
    10081 gttctagcat atctaaagaa cgcctacaag ccattctctt tttttcaata ttaaatttgt
    10141 cactatcgta acattcgacg taacataccg aacatagacg tatagcccaa cattcagaac
    10201 attgtggtaa gctttcctta caatagtcct ctatataacg atcaattaac acagtttcat
    10261 ctaaaccact gtaaacattc ccaactgaag gtgattttcc tatgcgttcg cataaatgaa
    10321 aatctccatt tgccgttaca tagattcttc ttgtcgcagg tgaacagcag ccatttaaat
    10381 tataattcgg gtaaggagtt tcagttaaaa tcctatcatg tattattgag aattgtttgt
    10441 gtaaaaaatc gattgtgaat gggttacttt gtgatgtata agtattattt aacatcagat
    10501 cagttgtcca gttccctaca gggttatcat aacaatgtat agggttttct tcagtaatcg
    10561 ttttctctat gtcagacgag tgtctcacat aagaaatatt tttagtaata tccttaggta
    10621 cccacgaaag agaattaaag aaattttgaa tttttttcat taccgcatca ttagttggtc
    10681 tgggtgttac catgcttagc gatataaggg aattactttt ttctccataa gcattaatta
    10741 gatatttaag accatgaatt gccttgtcgt aagtgcccgc gccattttta aatacccttc
    10801 tacaatcatg tatttccttt ggaccatcaa tactacatac aactccaaag ttagggattg
    10861 tagatagata ttctgcgatt tcagcagtca ttaaggttaa atttgttgtc attgaaaaag
    10921 ttagatcttt accagcgcca ttttccagag cataggctac acaatgcttt aataatttaa
    10981 attctattaa tggctcccca ccataaaaag ttaccgcgac ttttttacct gagtttttta
    11041 aagtataatc aattgctaac tctgctactt gccaagacat gtgtctacgt ccaaactctc
    11101 tgaagtctat gtttcctgaa tgatatatgc aatagtgaca tgccatatta cattgttcgg
    11161 tcaactccag tgtaacctgt tctagatggc tttttgcatt ttttaaaacc tcatcttctg
    11221 atagtgcaaa ggataaaaga ggaggagctt ggaataaatg ctgctcatgc gcaacatgta
    11281 ttaagtcaat tagaatagtc aatgtatcat cattaacttt aataggattt attaccttcg
    11341 ctatatctcc gtacaattgt aagttattta gaaatgtata ctctatttca ttacattcca
    11401 ttactttgcc tgtgcccaca tcatataaat aggatttatt ctttgtctga aataacttaa
    11461 atagtcgaga ataattccca tactgttttt cgatgtttct aaagaactcc ataactgtgg
    11521 aatccaatat catcacgttc cttttggatt tcgatattca ggatatggtc acatgctgct
    11581 aatagtctct ggtcatgtga taccacgatt gttatctttc ttgacttttg cttagtcaat
    11641 atttctacaa gtccacttac actctttgaa tctagggctg atgttggctc atcaagaatc
    11701 gttaagaatg aatctttact taatgcacga atcaaagata atttttgctt ttcaccacca
    11761 gaaaagttgc tcccattttc atttattaat atattttcaa ggttagattt tgttatcatc
    11821 ccttcaagac caaaggcatt tataagctca ttttggttac tagcagtctc tttcgaaaaa
    11881 ttaattccaa atcttaaata ttcctctatt ggtagattta aaaactccgg attctgttct
    11941 acataagaaa ttttaaaacg cctcatatta agcatatcca aatcttttat ggagcaatta
    12001 ttaaaagcta tctctcctgt gtaaagatca ctatatagac ctatcatagt attaagtaat
    12061 gttgttttgc ctgaaccatt atggccacat atcccgtaaa tttccccctt agaaaaatca
    12121 taagaaaagt ctctaaatac gctttcacca gaatatttaa cacctaattt tttaatactt
    12181 attttctcta attctacaag tgttgcacta ccataaatat cattttcaga tttcataatg
    12241 tcatttaacc gttctatcga tactttcgtc tcttggtatg agcttgctaa acttaataaa
    12301 tatgaggttg acgagatgat cattgaaagg taggtgttaa ttatagtgaa ctgccctaca
    12361 ctcatttggc caattacaac tttatgacct ccaattccaa ttacaaatat atagcagatg
    12421 atcaatataa attgatttag atttgagaaa atataattag ttttcacttg tgaagtcgca
    12481 actctaaata atgaattaaa tgctttattt aaccgctcat tcatttcatt aaagagtaca
    12541 ttcttcttta taaaaaccaa tttgttaatt tgttcgactt ttttagagta gtattcattt
    12601 gcttcttttt tgtatttcaa atttgcttta tacaattttt ttctaaaaac cacatatgta
    12661 aatatataaa atggaataag cgagaaaatt ataacgcata gtagtacatc agcttttaaa
    12721 acaataatac cgctgacaat tattgttatt acttgcaata ctaagttaga aatattattt
    12781 gaaaaaaagt caactactgt ggatgaatca ttattaattt ggtcaactaa gtatgcatta
    12841 tccttatctt tgaagaccga cagtttggtt ttaaatatct tttgatagat atcattgcag
    12901 atttcgtata ataataaatt attcaatttg gtagagaaaa gagcagttaa atattgtatg
    12961 agaatgtttg ctatatttat aatccccagt aacagtacaa aatataaaat gatacttata
    13021 ttactttttg atactaaata atcaatatat atgcctgtga tgtaaggcac aataattcct
    13081 ataatccaca atactgaagt aactgcaatg taaaaaaata catacttgcg cgtttttgaa
    13141 aggtattttt tcaagtattc taggactatc atattcatca cctatatttc atattaggta
    13201 aatcttagcg agatgctgaa acagcatctc gctaagtaat gttacttctc ttaagctaca
    13261 tcttgtagga acaagaaaga gtacagccac ttgaaccgtg gaaaggacaa tgtgcactta
    13321 cttgtacagc actttttact aatacgtcca tggtttttcc ctccttaaat tttaatttat
    13381 ataaataaca tacagttgaa aaactatatg ctacttatca cttttgagct gcaatagaaa
    13441 atgcactgtt ttcaagcgtg atatttattt ttgctttacc tgccccattt atatagttat
    13501 atgttaagtt tggtctaaac aatggccatc ccgcaggaac acttaatgca cttgcagtcg
    13561 tcttaactgt aaccgtgtaa tcggaagctc ctttactaaa agttaaggaa cctgaacctt
    13621 ttgtattgtc ataattaatg gcttttgagt atcctacagg cacacgaact gacattgagg
    13681 aaccatctac acctgtgata tcaagattag tatttagctc tggaagtgaa actccagcct
    13741 ttgtactttc caccgttatt ttttcataac ttttttcagg aattaaaata ttaactctgt
    13801 cggaaatgcc gttaactgag cctttcccct ttactgtgat gtaaattgta tatccactta
    13861 atgtagaagt gacagtatac aaggatttgt tatactcata actaaaatca cttgctgaag
    13921 tttttgtaac ggtgacatta caatttatag ccgttagatt gatattctta acatcatttg
    13981 aagctgcatt acttgaagaa cctaatggca tccccataag taagaaacca cataaaacaa
    14041 tacacatttt ttttagcatt aacatgattc agaaacctcc ttcttatttt ccgttaattg
    14101 tccagccagt aatactttcg tgcactcggt aatatactcc tgcaaattat aacgatattg
    14161 ctcacatatg ttaaagtctg ccattctatt gtgagggcat cctcctaaac acacaggtaa
    14221 gtacttacag tctgaacatt tttcatcttc agtaggatca tataataaat aacaaccaag
    14281 aagctcagta ttccatttca ctgatgtatc ttcatttata attccaacac actgctcaat
    14341 aattccaata tcgctccaac atttatataa atgaccaaga ggatcaataa cgaaactatt
    14401 atacttatcc gcagaacaat aattaccttt aggtgcagga taaatataac taattgggat
    14461 atcattttcc gacataaatt ttaaattaaa ttttgaatac atctcgtctg tcaagcactt
    14521 agttccctca tactttccat tcgtcggcgt aactaatcct agataaggta ttacattttc
    14581 caataaagaa ttttccttta agaatcctac gatttcatgt aaattcaacc agttgtcttg
    14641 gtcagtattt attctcataa atatcttaat catcccttta atttgcttga ggttattcat
    14701 tatgacatca aatgtccctc ttccacttac taaagggcgt ctaagatcat gtacttcttt
    14761 aggaccgtca acagtgactt gaatatcatt tactccacat gagattaacg tttgaacttt
    14821 ttctttattt aaaagatagc cgtttgtaat gacactggcc gtatattgta tattgttttc
    14881 tttacatatt tccaaaaaat cttccgatat cctaactatc tgcttcattg caatcaaggg
    14941 ctcaccgcca taccatgtaa cattaagagt gtcaagttta ctagcatttg ttttaacaaa
    15001 attgactata ctttgagctg tttcttcact catagttttg ttatgatatt ggtctttctc
    15061 aaaacagtat acacatcgaa aattgcaggc cattgtaggg gcaattgtta gcattaaatt
    15121 agaagattca aaccgatttt ttaagaggtt tacctttaca tatgcttttt cattcatatt
    15181 atcttctacg atatagccac attcgataag atttttaaga taagtatcat tatttattgc
    15241 caatccattg tttgtaagtt cgcaaaactg tttatagtac tccggttcaa gaactgccaa
    15301 tgcacctgtt cgagaattat aaagtaccgt tttatcggta ttttcaataa tgtcattaaa
    15361 aataaagtta tattgcgaag ctttcatttt agccctcctt agaatggata cggtccttat
    15421 gtaattatga atcgattatt aattagtgac aaaattcaca taagttttaa aaataagatg
    15481 tacgctcatt ttgagttgca aatttcattc ttgcagtgca ccctagatag cttttacttc
    15541 tcggctttta atgtagcata aggcaaaaag aaaaaataag cttgtatcct gaaatgcaaa
    15601 aaaatccatc tcaacgacca aatatgtcag cttcatgtga gattaacatt tttgttacct
    15661 atatttcttt aatggtaaag tacgttactt gttaattctt tgtttatatg tccaaagaaa
    15721 ataaaggatt agactgcttg agaccgcagc aaagattaaa agcactagga gcgtgcaact
    15781 gcttgttcct ccgttgttgt aacgcgaact gaaccagtag agctttagct gaatactttt
    15841 ataaaggctg aaaataaggt ttctaagcaa taaaaaagaa catatccatt ccctcgcctg
    15901 ggctacgtcc tctccacagt ataagtatgc atttgaactt ttactaacaa aaattccata
    15961 acctgatggt aattattttc atatgtaaaa catcacttcg aatagacttt ttttacaata
    16021 tactggattt atataacata tttgaggtgg tctatttgtt tcaagttgct gtttgtgacg
    16081 atgatcccgc aatgcataaa attttacaac actttttcat gtgtatgtca gtaagtgaat
    16141 ccttagattt taatctacaa ttctttttat cgggggaaga tctaatcaaa tcttatagtt
    16201 cacaagagcg atactccttt catattatct tgttagatat tgaaatgagg gaattatcgg
    16261 gaattgaaac tgcaaaactt attcgccttt ttcctgaccg agaagttcaa atcatatttc
    16321 taactaacta tccagaatac atgctagaaa gttttgaagt acaagcattt caatatttac
    16381 ttaaacccct tacttataaa ctctttgtag aaaagataaa taaactatgt cattatatgc
    16441 gttcttcagt atcccacttt ctatctgtga aaaataaaac tgagcatctt gtattgagac
    16501 actctgaaat catagccatc tcaaaaggtg aaaacaatta catccataat gaactttgta
    16561 ttgcaacgga ttcacacaac tattttattt ccggaacgtt gaaagcggtt tatgaacaat
    16621 taaaatatcc gtttgtgttt atacataggt caataattgt gaatttagtt catatacgta
    16681 agttttcaac tacttctgtt attatgtcaa accaacaaga atttcctgta ggtcgttctc
    16741 acgctaaatc gcttcgtgag gcgtatgctc gttttataat ttctcgtttt caggaagggt
    16801 gagttttttg aatcattgcg tttacattaa tgtcacctcg ttttctaatt actctttatt
    16861 tttgtttagc acaacaaagc aaagtgattt ttccaatcca atagttaacc tttttttact
    16921 tttcgcctct ttatacttca tacttattat agtactattc gttcattatt taaaaaaagg
    16981 aagaaaatac aatataggga ttatgtatta ttttgtaata ttaataggaa catcgtttaa
    17041 cttattcata cattatagtt tattttcttt aatgaaatat aattaattcc ttataatgtc
    17101 aataatcggt attattggaa tgaacgtaat tattgtcttt ctaatggaca agctgataga
    17161 aaagtcaaac ctctcacgct tttttcaaaa gcaaatgctg atgcaagaaa aacattataa
    17221 agaaacaact cgatctctta gtgatatcaa acgaagtatt catgatttca aaaaacagtt
    17281 aatatttgtc cgtgcttgtc tacaagaaca gaggacggaa gagggtgtta atcacattaa
    17341 ccaaactcta gaaaatatag aatcaccacg acttcatata acaacaggac atcttgttat
    17401 tgatgccttg gtaaatcaca ctttcagcat cgctgataaa agtgggatag ctttctttca
    17461 tcaaatccat attaaccctg caaacattag tattggaagt catgatctat gtattgtctt
    17521 aggtaatgtt ttcgataatg ctattgaagc tgtaaggcag cttcctagaa agaaagagca
    17581 ttcaattcat ttggaaattt taaccgataa ttctgcccta tggatttatg ttcgcaattc
    17641 aaaaagtaat tgtctcaata cagcattctc aaccaaaaca tacacccccc ctttaaaaaa
    17701 acatgggtat ggattactta acatccatca agtaataaag aagtacggtg gttatttaaa
    17761 tacaacaatt acggattcaa attttcaaat tacgattatg attccatgta ataaccctta
    17821 gatttgtaaa cattatgaat taatggctat tcagaataaa taaaatgtcg gtaaatacca
    17881 gtcttataac aattaaaagg gagtgtcctc aagcctatga tggctgagag cactcccttt
    17941 tattatttat gaattgatcg tttgtccttt ttcttctact tggatagccg cccctacatt
    18001 ggcacctgca agaatgccct ttttcttatt aggatacaaa gaattcatat aggttcgggt
    18061 ttctgcaacg acaatgcctg acaagccgag cagtgcaatc aggtttggaa aagccatcat
    18121 tgcgttaaaa atatctgcca gcagccagat ggcatcgagc ttgatgaacg cgcctccggc
    18181 aaccagtatg atgaacagat aacggtatgg tttaatccac ttgaccccaa gcaaatattc
    18241 aacacagcgt tccccgtagt agttccagcc aagtatcgtt gtgaacgcaa ataaaataag
    18301 gctaatcgtc acgagctctg ctccagccgg aaaggcactg gaaaacgcat gttgagtcat
    18361 cagacctcca tcatcatttc cactccatat tcccgtaacc agcaatgtaa atcctgtcaa
    18421 attacaaata atcatcgtat cgataaaaac gcccgtcatg gatattagtc cttgttctgc
    18481 gggccatttc gtcttagctg ctgctgctgc gattggcgca cttcccaaac cagcttcatt
    18541 tgcaaagatc cctctggcaa ctccgcttcg catcgccagc ataatcgtgg ctccggcaaa
    18601 tccacccgtc gcagatgttg tcgagaaagc cccttgtaat actagtgcga tcgcatgagg
    18661 aagctctcct gcaaacttaa tgagtacgat taaacaaacc acgatataga gccccgacat
    18721 gaatggaaca atctttgtgg ataccttggc gatacttttg agtcctccaa tcgtaacaac
    18781 agccgtcaac acggaaataa tgattgctgt aactactgtt ggcacgccaa agctactttc
    18841 cgtagaagaa acgatagcct ttacttgcgg aaaagtaccg attccaaata gtgctacaag
    18901 aataccagaa aaggcaaaca acatcgccag cggcttgaaa cggcggccaa gcccgttttc
    18961 aatataatac atcggtccac ccgaaaattg tccgttccgg tctttaacac ggtatttaac
    19021 ggataatagc ccttccgcat atttggttgc catcccgaaa aaagctgcaa ccagcatcca
    19081 gaataatgaa ccgggcccac ccagtttgat cgctgttgcg acaccgacga tacttcccgt
    19141 acctacagta gctgcgagtg ccgtactcaa tgctccaaag ctactgacat ccccgctgcc
    19201 ttcgtccggc gctttaccaa ttagcttgag cgctaagggc aatcgaataa tctgaagcat
    19261 cttcagacgg atcgttagcc acaacccagt gcccatgacg agaattagaa gcggcgctcc
    19321 ccacatccaa ctgtcaattg tttctaataa atgtaccaaa ttcatttcaa cccgctcctc
    19381 cagcatatta aaaaacaaaa aagagtcaaa tccgttgatt cgactcctgg agaggttaaa
    19441 ggcacgaaaa ataaaccaat ttgtacagga ttttatctct aaaaagccta gagtattccc
    19501 tgtcacaggt tattcgcgtc tctgtccttt tgcctgagag tttaagcaga tgataatctg
    19561 cggtgcacct tcggcgccca attaagggtc tctccagagt tctgtccgtt tacggtccct
    19621 gcttgttgct gtaaatcagc ttaagcacct gagagttttg ccccttcggt cggaactttc
    19681 gttccatctc ccgcaaacat caaccagaca tatgaaattt ttatttatta tacagaaaac
    19741 tttcagcgta ttacaagtga aaaatttgtg aagccctctg acaaatcaat agggtgtcta
    19801 tacaaaaagc gggtacagca gattgcatcc taaggatttt ctctgctgta cccgccaaaa
    19861 cgatatagaa ttacaattct tcaccattgg ttgctatcac atttttatac cagttaaatg
    19921 agtccttttt ggagcgttgg agcgttccgt taccgtcatc atccagatca acgtaaataa
    19981 atccgtagcg cttggacatt tcggaagtag acatgctcac aaggtcgata ggaccccagc
    20041 tggtgtaacc aatcagatca acaccgtcag caatggcttc cttcatttgg gcaatatgct
    20101 gacgcaagta atcaatgcga tacgtgtcat gcacagagcc gtcctcttct accttatcgt
    20161 acgcacccag gccattttcc acgatgaaca gcggcttttg gtaacggtca taaaacgtat
    20221 ttagtgtaac acgcaggccg atcggatcaa tctgccatcc ccaatcggag gattgcaaat
    20281 acggattttt cacaccgcca atcaggttcc ctgctgcctt ttctccttct ggacctgccg
    20341 atacggtcaa ggtcatgtag tagctaaatg agataaaatc aaccgtatta tttttcaaaa
    20401 tttcagcatc gccgggttct gtctggatca caatattatt ttcttcaaaa tagcggttca
    20461 tatagttggg atactcccca cgagcatgca catccgtaaa gaacaggttc atttgatttt
    20521 catgctgtgc tttcagaata tcctctgggt tacacgtatg tgggtagctt tcaatgcgag
    20581 ccagcataca gccgatctga gcacccggaa tgatctcatg tccccgtttg gtcgccagtg
    20641 cacttgctac aaattgatgg tgcaatgctt gatatatcgc ttgttgtttg ttttctacac
    20701 ggtcaataac cacaccgccg ccagtaaacg gactcatggt catgacattg atttcgttaa
    20761 aggtcagcca gtattttact ttatccttat agcgtgtaaa taccgtttcg gcatatttta
    20821 cgtaatgatc tacgacttcg cgtcccaacc agccattata cttctgtgtc agacctagcg
    20881 gtgtttcata atgtgacaat gttaccaacg gctcaattcc atacttgcgc agctcatcga
    20941 atacattgtc gtaaaattgc aatcctgctt cattcggctc ggcatcatat ccattcggga
    21001 aaatccgcga ccagtggatg gacatccgga atactttaaa gcccatttct gcaaacaaag
    21061 caatatcttc tttgtagcgg tggtagaagt ccactccttc acgctttgga aaacgggcgt
    21121 ttaccttccc tgccaagatg tcctccagtc gttcagacga aatttctata gcatgatcgt
    21181 ttttacgttc tgccttaggt acataggcta tcatgtctgc gctggacagg ccttttccat
    21241 ctacgtcaaa agcaccttcc aattggttgg ctgcagttgc cccgccccat aggaagtttt
    21301 gcgggaatcc ttttagcgtc ttcgtcatgg tatgaaaacc tcttttctta tctaatgttt
    21361 tcactctagt caataaccca tcaggtgctg caatgcgaat caataactaa cggtgaccgt
    21421 tatcctttga aatgcaccga tagatgcttt aaaatagacg taatgccctc ataagcatcc
    21481 taattgttgt aacgcgtttc atgtcaagta tttttttctt aggtgaggag aagcatcatg
    21541 tcgaatcttg atcaaattgc aaaactggcg ggcttttcca aagctacggt atccagagtg
    21601 ttaaatcagt ccccccatgt aagccacgaa accagaacta aaattttaaa aatcatgcag
    21661 gaattagatt atgttcctaa tcggaatgcg atttctttat ccaagggcca aacgcttcag
    21721 attggtatca tcacatcaac tattaatgaa attgttctgg catttctgga cagctttgta
    21781 gaaatcgcag gacaatatga atttcaaacc attatttata cttcgggaga agacaaaaag
    21841 aaagagcttc aagcattcga ggatttaaaa agaaaaagag tcgatgcgct ggtcatcatt
    21901 tcctgcgtga atgacactga ttttttgagt acttattgca aatatggacc gatcgtggca
    21961 tggcaacgaa tggagcatac cgatattcgc tccgtcgcaa tggatcagta tgaaggatat
    22021 atgttagcgc tcaaacattt gatacaaaaa ggctatacac gtatagccaa tgcttttggt
    22081 cgtccaagca gcatcaatac tcacagcaga caacgtgctt atgagcagat catgagtgaa
    22141 cacaatctgc cagtgttgca gcactggaac tattcttcta tttataacat tcgtgacggc
    22201 gaacaggttg tgcgcaattt attacagcat cgtgaggaat ttccggaggc tattttgtgt
    22261 gcaaacgatt atgtagcagt gggcattctc tgcgaagcgc gcagacaatt gctgaaggta
    22321 ccagaagatc tggcgattat tgggtttgat aacacggagc tggcgcacac gatgggaatt
    22381 acaacggttc aaaatcccat aatggctcag gcacaaaatg cttttttcat gctttctcct
    22441 cagctgattg gacgccagat ggagcttcat tcactggagt acagcctcat tgagcgtaca
    22501 accacttaag agcacagttg gctcgcaaac taggcaaatg ggccttaata taaaatattt
    22561 tttgtcgaaa gagaataaaa tatgttgaaa tcgctttttt ttgtgctaca atagcactat
    22621 atcgaaggat tgtgaccggt gatgcgggca atgcctgagt tcaattgagt gctattgcta
    22681 acaatagtat tgaattgtgc ttgggcattt tttattggta aaggatggga ggggggaact
    22741 tcaatgatta ttgagaaggt gctcaataac aacgtcctgt tgactaaaaa cgataaaggc
    22801 aaagaggtca tcgtcatggg aagaggtatt tccttcaaaa aggtggctgg cgacccagtc
    22861 gatgatcata aaatagataa gattttcatg ttaaatgaaa acgagttcac ggccagacta
    22921 actgagctgc tgaacgatat tcccgtgtct catctggagg tcgtgaatga aatcgtgacc
    22981 catgcagcag aagtgctgga tacggagtta agtgataaca tttatttaac attgaccgac
    23041 catattcatt ttgccataca gcgggaagaa aaaggattag cactcaaaaa cgcgatgctg
    23101 tatgaaatta aacgctttta caaaaaagaa tttgcagttg gactggatgc tctgcaaaaa
    23161 atagaaaata cgctcggtgt aaaattgggc gaagacgaag cgggatttat tgcattgcat
    23221 atggtgaatg cacggatcga cggtaacgag atgaaggcta cactgaaaat gaccgagatt
    23281 gtccaacaca tattgaacat tattacgtat cattatggga ttgtgctgga tgagtcttct
    23341 tttagctatt cgagattttt gacccatttg caatattttg caatgcgagt gattcgcaaa
    23401 gaggttattc acagtggtga agaatttttg tacaaccagg taaagcaaac ctataccgaa
    23461 gcttttgctt gtacccaaaa aattaatgaa tatctagaaa aaacatatga tcaatattta
    23521 agcaaagatg aatatgtata tctaacgatt cacattcatc gggtaactga gcgtaataac
    23581 atatcaggct aaaaatttca tatcctcatc gttcatggat tgtgactggt aaggcaggca
    23641 aaacctaaac tgatggtgaa atcaacgttc cctcatagaa ggagtgcgtc gttttcacca
    23701 cgagtttagg tttttcttgt ttacaaggtt ataaagatgc acgccggcgc atcttagcaa
    23761 cagctgtaaa cggtaaatcc tatcagtagc aagaataaca cttaaggagt tctgaacatg
    23821 agtgataaag agctatccaa aaaaatagtg actctcgttg gcggcgaaga gaatgtcaat
    23881 tcggtatttc attgcgctac acgcttgaga tttaaattaa aggatcgcac aaaagcggac
    23941 aaagctgcac tggaagctac gcctggtgtc attacagtgg tggaaagcag cggacagttc
    24001 caagtggtca tcggtaacaa tgtaggccaa gtctttgagc atatgatggc agaaacaaat
    24061 ctgcaggatg cggataatcc aaatgcgaaa aaagaagaat cttccgaaaa aacgaatttt
    24121 ctcggcaaag cggtcgatat catttccagc attttctccc ctctcttggg tgctcttgcc
    24181 ggagcaggtt tgctcaaagg gattatggcc ttaattgcgt cgctccattg gattgatact
    24241 gcaagcggta cgtatctcat tctgaatgcc gcttcggaca gcgtatttta tttcttgcct
    24301 atattcctag ctattacatc gtcccgtaaa tttaagacca atgcctttgt atcagtcgca
    24361 gttgctggag cactcgtgta cccggatgtt attgcagcgg tggacaatcc ggcaaaactg
    24421 gcttttctcg ggattccaat cattctgata aaatacagtt ccagtgtaat cccaattatt
    24481 ctcgcggtat gggtacaatc ctatgtggaa cgctggttta attcctttgt tcatcaatca
    24541 gttaaaaaca ttatcgtacc tatgctatca ctgctggtcg ttgttccatt gacgtttttg
    24601 gcctttggtc cagtcggtaa cctgattagt caaggcttgg cgaacggttt tacatgggta
    24661 tacaatttaa gcccattgat tgccggggct gttgccgggg cgttctggca agtatttgtt
    24721 attttcggcg tacactgggg cttcgttcct attatgctgt ccaatattca aacattgggt
    24781 tatgacacga tgcttccaat acttacagca gccgtacttt ctcaagctgg tgcaacactg
    24841 ggggtattcc tgaaatcacg aaatactcaa atgaaggctt tggctggttc ctctacactg
    24901 gcagctgtat tcgggattac tgaacctacg atttatggtg taactttgaa attgaaaaag
    24961 ccgttcattt atgcttgtat ttctggtggt attgggggcg cgattatcgc ttccggtgga
    25021 gcgactgcaa aatccttctc cctgcctagt ttactggcgc ttccaactta ttttggagct
    25081 ggattcttgt gggttgtcct cggcttactt gttgcctttg tactcgcagt tgtattggtt
    25141 atgattttgg gctttgatga tccaaaagaa gaagctgtaa aaacagaaac agcacccgta
    25201 aaaaaagaag taacaatcga aaaggaaatc ctcgtaagtc cgttgcaagg taaagtgctg
    25261 ccattggaac aatcttctga tgttgctttt gcttcaggcg ctatggggaa aggaatcttg
    25321 atcgatccta cagagggtgt gctgacatct ccggttaacg gaacgattac gaccgtattc
    25381 ccgaccg
//
