LOCUS       NC_017542              20679 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Paenibacillus polymyxa M1, complete sequence.
ACCESSION   NC_017542
VERSION     NC_017542.1
KEYWORDS    RefSeq; complete genome; complete replicon.
SOURCE      Paenibacillus polymyxa M1
  ORGANISM  Paenibacillus polymyxa M1
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Niu,B., Rueckert,C., Blom,J., Wang,Q. and Borriss,R.
  TITLE     The genome of the plant growth-promoting rhizobacterium
            Paenibacillus polymyxa M-1 contains nine sites dedicated to
            nonribosomal synthesis of lipopeptides and polyketides
  JOURNAL   J Bacteriol 193 (20), 5862-5863 (2011)
   PUBMED   21952539
REFERENCE   2  (bases 1 to 5864546)
  AUTHORS   Blom,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2011) Cebitec, Bielefeld University,
            Universitaetsstr. 25, D-33615, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 01:49:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,687
            CDSs (total)                      :: 5,531
            Genes (coding)                    :: 5,427
            CDSs (with protein)               :: 5,427
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 45 of 104
            Pseudo Genes (incomplete)         :: 71 of 104
            Pseudo Genes (internal stop)      :: 16 of 104
            Pseudo Genes (multiple problems)  :: 23 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:14:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3192998
            Orig. end                         :: 3213677
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE577054.1.
            Accession number for plasmid pPPM1a in this genome project:
            HE577055.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20679
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="12"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20679
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20679
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10679](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10679)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    complement(849..865)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 26.96"
                     /tool="antismash"
     gene            1139..2626
                     /gene="abc-f"
                     /locus_tag="PPM_RS14210"
                     /old_locus_tag="PPM_2727"
     CDS             1139..2626
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="abc-f"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821979.1"
                     /locus_tag="PPM_RS14210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2727"
                     /product="ABC-F type ribosomal protection protein"
                     /protein_id="WP_013371530.1"
                     /transl_table=11
                     /translation="MPAIQVTNLTFAYPGSYDPIFENVHFQIDTDWKLGFTGRNGRGKT
                     TFLNLLQGKYEYSGTISTPVAFDYFPFPVEHPEYLTLDVVEEIVPSYENWKLMRELNLL
                     KVSEDVLYRPFESLSQGEQTKVLLAVLFIQDNRFLLIDEPTNHLDLHARKLVADYLNTK
                     RGFILVSHDRAFLDRCVDHILSINKTNIEIQKGNFSSWWTNKTRQDTFEMAQNEKLYKD
                     IQRLSASAKRTSSWSFETEKSKNGTRNSGSKLDKGYVGHKAAKMMKRSKSIEQRQHTAL
                     EEKSKLLRNIEQSESLAISQLVYPKSELAILDHVTIYYGERAVCKNVSLMIEPGDRIAI
                     SGPNGSGKSSLLHLLNAEELYYTGTFQRDPQLRVSYVSQNTSDLRGTLSDYAAEHRIDE
                     SLFKAVLRKLDFARIQFEKDISAFSGGQKKKVLIARSLCEEAHLHIWDEPLNFVDVISR
                     MQIEELLLEYTPTIVFVEHDREFHDRVATKTIELGGD"
     gene            2773..3261
                     /locus_tag="PPM_RS14215"
     CDS             2773..3261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010347476.1"
                     /locus_tag="PPM_RS14215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_228392860.1"
                     /transl_table=11
                     /translation="MAADGFIEDSLIVISLRLRSLYYFTVGFASSTLLSLSIMGNSASN
                     AIAKRTTGSIKFDQGSISQLVLAVCDFYQQPRLQCRQSNISLVIPQLKEKILSELNLYL
                     LKSVENLYTDMEKDLFVSIYANVIYEAGYLWASGKVKLNKEEIAKKISLFVLGGQNSL"
     gene            complement(3811..4629)
                     /locus_tag="PPM_RS14220"
                     /old_locus_tag="PPM_2728"
     CDS             complement(3811..4629)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (19-251). E-value:
                     1.4e-14. Score: 46.3. Matches aSDomain:
                     nrpspksdomains_PPM_RS14220_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017427996.1"
                     /locus_tag="PPM_RS14220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2728"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_013371532.1"
                     /sec_met_domain="PF00561 (E-value: 8.1e-08, bitscore: 30.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYCKVKNANIYYEEIGKGKPIIMIHGFTPDHRLMSGCMEPIFED
                     NSNWRRIYLDLPGMGQTKDYDQICNSDDMLEAVINFIETLVPNQDYLIAGESYGGYITR
                     GIINRHKDRIGGAALICPLIIPEHKRRILPEHFVVHSDREFMDTLSEEQVSDFSANQVV
                     LNEYNWKRYSEEIMAGCKIADYDFLSKIQRNYGFSTNIDELVFDKPTVFTLGRQDAVVG
                     YIDAFRILDNYPRATFAVLDRAGHNLQIEQTLLFESLMREWLERVTEFGF"
     aSDomain        complement(3877..4572)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PPM_RS14220_Abhydrolase_1.1"
                     /evalue="1.40E-14"
                     /label="PPM_RS14220_Abhydrolase_1.1"
                     /locus_tag="PPM_RS14220"
                     /protein_end="251"
                     /protein_start="19"
                     /score="46.3"
                     /tool="antismash"
                     /translation="KPIIMIHGFTPDHRLMSGCMEPIFEDNSNWRRIYLDLPGMGQTKD
                     YDQICNSDDMLEAVINFIETLVPNQDYLIAGESYGGYITRGIINRHKDRIGGAALICPL
                     IIPEHKRRILPEHFVVHSDREFMDTLSEEQVSDFSANQVVLNEYNWKRYSEEIMAGCKI
                     ADYDFLSKIQRNYGFSTNIDELVFDKPTVFTLGRQDAVVGYIDAFRILDNYPRATFAVL
                     DRAGHNLQIE"
     misc_feature    complement(4760..4773)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.25"
                     /tool="antismash"
     gene            complement(4899..5162)
                     /locus_tag="PPM_RS14225"
                     /old_locus_tag="PPM_2729"
     CDS             complement(4899..5162)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010495290.1"
                     /locus_tag="PPM_RS14225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2729"
                     /product="hypothetical protein"
                     /protein_id="WP_013371533.1"
                     /transl_table=11
                     /translation="MFTREEIQSWEDEKQRSLEINNKPKDPRKEKLKDFRKGIKSVHYN
                     KECKVARKDDYRLYRTKMKRLMRSEEYEILHSYKRTSGWITW"
     misc_feature    complement(5283..5300)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.83"
                     /tool="antismash"
     misc_feature    5352..5364
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            complement(5436..6353)
                     /locus_tag="PPM_RS14230"
                     /old_locus_tag="PPM_2730"
     CDS             complement(5436..6353)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687453.1"
                     /locus_tag="PPM_RS14230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2730"
                     /product="hypothetical protein"
                     /protein_id="WP_013371534.1"
                     /transl_table=11
                     /translation="MEANQNIRLAIEESIQFLESTPHLGMTHGECSRRKWDGAWWHMAA
                     LYEMGEVKLIPESAITGAKYLLETQVWPTFIIFPDDHPTSESDKMKMDCCHCELAVYYM
                     ILMAYGCDLDKELPWIREWLLKHQLPDGGLNCDPEAYIHSKKSSIVSTLPPLEAILWHT
                     DREFTEQEVVFLDEGARYLIEHRLVCSKQNRSVIDMEWLKPCFPRFFEYDILRGMSFLA
                     EWSRRRNKTLPVGLLIEGLERLNIFRETEGLRIGRQVFDPQGPWGGQSFPLLEAVSGIG
                     DVSPYLTRQLDRIIERLGPEYTYA"
     gene            7598..7789
                     /locus_tag="PPM_RS30165"
     CDS             7598..7789
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPM_RS30165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_228392861.1"
                     /transl_table=11
                     /translation="MTRLLDARTSQNASYGNTISIPLPANTAGAIAELGLDVTECPLLC
                     ECLRNKPKRCTSRHHQCF"
     gene            8025..8246
                     /locus_tag="PPM_RS14235"
                     /old_locus_tag="PPM_2732"
     CDS             8025..8246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821990.1"
                     /locus_tag="PPM_RS14235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2732"
                     /product="DUF6199 family natural product biosynthesis
                     protein"
                     /protein_id="WP_014599895.1"
                     /transl_table=11
                     /translation="MGIMLILIAIVFFALGILSKRKPTWGWRANEAWKIKGDSEPSDAY
                     IDDMKFRGSVSILFGFFFLACGLLVIFL"
     gene            9151..9363
                     /locus_tag="PPM_RS14245"
     CDS             9151..9363
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821992.1"
                     /locus_tag="PPM_RS14245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_043921417.1"
                     /transl_table=11
                     /translation="MKISRGRCRLKELLEERRIKQIDLARRTGYSRHLISNWANNQDKM
                     SADVMINIAYALDCKMEDLYELIFE"
     gene            complement(9591..9986)
                     /locus_tag="PPM_RS14250"
                     /old_locus_tag="PPM_2733"
     CDS             complement(9591..9986)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599896.1"
                     /locus_tag="PPM_RS14250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2733"
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
                     /protein_id="WP_014599896.1"
                     /transl_table=11
                     /translation="MLSLTVSADPGGIERGENVLVDKVLFISKGRKRDQILVHTFDKTY
                     YMVGTLRHWENFLNSNGYRFLNVDRSNTLNVEKVKIVNGIFKDAYFEDEVTKTSKRCPI
                     AYHRFDEVVEEMGFINSKIIFTGVATK"
     gene            complement(10001..10147)
                     /locus_tag="PPM_RS28650"
     CDS             complement(10001..10147)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821994.1"
                     /locus_tag="PPM_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_080567867.1"
                     /sec_met_domain="TIGR04223 (E-value: 3.1e-08, bitscore:
                     31.8, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTKPSKVKASMYYNIAAMLTILAVASVSTASLSWIHSPEPPKE
                     LLK"
     gene            complement(10125..10679)
                     /locus_tag="PPM_RS14255"
     CDS             complement(10125..10679)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009372 - quorum sensing [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821995.1"
                     /locus_tag="PPM_RS14255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_043921418.1"
                     /sec_met_domain="AgrB (E-value: 1.7e-19, bitscore: 68.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITIKSLDTIALNIATHIKTVVPDHPSSIDVLKHGISVAINTVSI
                     ILLTIGISFFTDRMQEALLAMISFSMLRQIVGGIHLKSNIVCIVVSTVLLTALSFASFN
                     YNWIVITSIISIVLILIYAPSRVEGKTRISKKHYPLLKFMGVAIVALNLWLAFPVVAAS
                     FFVQSLTLIEGGVKNEENQTE"
     gene            complement(10657..11289)
                     /locus_tag="PPM_RS14260"
                     /old_locus_tag="PPM_2734"
     CDS             complement(10657..11289)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014281450.1"
                     /locus_tag="PPM_RS14260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2734"
                     /product="hypothetical protein"
                     /protein_id="WP_014599897.1"
                     /transl_table=11
                     /translation="MWEPVRFLLFSTVETFAAFVLMLTIFRVRALDYIWPALFIGLIMN
                     LQSFILREETSLSFFAPTINIILFTLLITTVVRMPIIWAAIISITGTFLYTLFQAAVIL
                     MLFGTLTTEMQTSAEGSLAQAVTSAWVLAISWFLYKFKIGFTADYENLRFKWEYVLVII
                     LIIGVLAACAFMFYVNNFFLSILFIALASAMFLYYALKTERDYYKKP"
     gene            complement(11414..11746)
                     /locus_tag="PPM_RS14265"
                     /old_locus_tag="PPM_2735"
     CDS             complement(11414..11746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821997.1"
                     /locus_tag="PPM_RS14265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2735"
                     /product="YolD-like family protein"
                     /protein_id="WP_014599898.1"
                     /transl_table=11
                     /translation="MGKRLEGNGLWESSRIILPEHKEGYLKLMKDRQRRGKPELDDQEV
                     QLIEQALIDSYNSRQPVSVTVFSPFDDTDMTGVVTSINTARREVKLFRGEDDFSWIRLE
                     DIISAG"
     misc_feature    complement(11799..11812)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.4"
                     /tool="antismash"
     gene            complement(11869..12141)
                     /locus_tag="PPM_RS14270"
     CDS             complement(11869..12141)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428550.1"
                     /locus_tag="PPM_RS14270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_043921419.1"
                     /transl_table=11
                     /translation="MLSDIERKLLRILYNFFAQQRRMPTMQELEIKTGRSVEDIKSGLL
                     SLESDNYITWEDQSDTRHIVIIEGWERGRSRPMSPGDANRYFTEY"
     misc_feature    12172..12185
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.46"
                     /tool="antismash"
     misc_feature    complement(12172..12185)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 22.28"
                     /tool="antismash"
     gene            complement(12391..12807)
                     /locus_tag="PPM_RS14275"
                     /old_locus_tag="PPM_2736"
     CDS             complement(12391..12807)
                     /codon_start=1
                     /function="uncharacterized conserved protein"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018887420.1"
                     /locus_tag="PPM_RS14275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2736"
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="WP_014599899.1"
                     /transl_table=11
                     /translation="MDKYIYPAIFEKGEVKGYTVTFPDLPGAITEGDDMSEALRMAKEC
                     LELQLFGLEEDNEVIPPASDPASIQLPPDSFITLIEIRMGTIRDEMMNKAVTKNVTLPR
                     WLEREATREKINFSQVLQHALKERLGVKDYPTAK"
     gene            complement(12834..13001)
                     /locus_tag="PPM_RS28195"
     CDS             complement(12834..13001)
                     /GO_function="GO:0003729 - mRNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010329616.1"
                     /locus_tag="PPM_RS28195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system HicA family toxin"
                     /protein_id="WP_065762441.1"
                     /transl_table=11
                     /translation="MIKIIEADGWYLARVRGSHHQFKHPTKSGLVTVPHPRKDLDPKTA
                     DTILKQAGLK"
     misc_feature    13039..13052
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.68"
                     /tool="antismash"
     misc_feature    complement(13085..13101)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            13211..14080
                     /locus_tag="PPM_RS14280"
                     /old_locus_tag="PPM_2737"
     CDS             13211..14080
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF005796.0"
                     /locus_tag="PPM_RS14280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2737"
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_331458175.1"
                     /transl_table=11
                     /translation="MVYLFISPMLLETAAAPFSDSRYIFEPKIDGHRLIYSQQNGIVRL
                     FTRHNNDCTRQYPEIASVTFPHDIVLDGEIACVDPTTGVSDFESVMSRFQARKTDKITK
                     LVAELPATFVVFDVLSFKGEDLRSLPLMERKSILASLTLPSPSFGVVPYIEGAGEALFE
                     QIEARGMEGLVAKRKDSMYISRRSASWQKVINWSYADVYITGYRKEEFGWLVSVPNERG
                     NLRPAGIIEHGASPMHKKAFYGVVAPLKTDEDREFVYVEPRIRARVKMRNWTKAGNLRI
                     PVFTEFIV"
     gene            complement(14111..14332)
                     /locus_tag="PPM_RS14285"
                     /old_locus_tag="PPM_2738"
     CDS             complement(14111..14332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686522.1"
                     /locus_tag="PPM_RS14285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2738"
                     /product="hypothetical protein"
                     /protein_id="WP_043921420.1"
                     /transl_table=11
                     /translation="MNHTYKVLKSDIELFAAALSQVKVYVVQSLGEDFISVVDYGGTIE
                     KFSPDSVKIAGAYYIRNQFEFRVDKNPR"
     misc_feature    complement(14384..14398)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.35"
                     /tool="antismash"
     gene            complement(14593..15051)
                     /locus_tag="PPM_RS14290"
                     /old_locus_tag="PPM_2739"
     CDS             complement(14593..15051)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687467.1"
                     /locus_tag="PPM_RS14290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2739"
                     /product="hypothetical protein"
                     /protein_id="WP_014599902.1"
                     /transl_table=11
                     /translation="MKIRKVLSVLFAATLTLTLSQSAFAISGQNDTRETALNVQSSNFN
                     FGSYLDKNDVDWFKVVNTSRSKEMTAIATLKSQQYINYDIVAYYPDKGEEEVLEAQDNG
                     QGKNDVCGTSGLLPGDVIYFKVIGHDGAWGGNGKGLGYSLNIKRDFDR"
     gene            complement(15174..15884)
                     /locus_tag="PPM_RS14295"
                     /old_locus_tag="PPM_2740"
     CDS             complement(15174..15884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599903.1"
                     /locus_tag="PPM_RS14295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2740"
                     /product="C39 family peptidase"
                     /protein_id="WP_014599903.1"
                     /transl_table=11
                     /translation="MLKKIMIPALLGSVVVGLLPENAAFADQVTTVTDSTYSTQSTTPD
                     ITQVITPSIIGLKRISDVPDFDWGRGCTISSAAMIIKYWESHGYPLLIDRGVSDDELQD
                     ILADKYFHPDKDGGVPFVRAVNAFARYLDDVGYIYSFGGYGFATNSAQEKAWNLITEEI
                     NAGRPLWLTMKRYQDDRRSIEGGHALVIVGYKQNASGQERKLILHTTWKEGNVNYEWRP
                     SDFDAVYRLKMGSK"
     misc_feature    complement(15954..15969)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            complement(16059..16505)
                     /locus_tag="PPM_RS14300"
                     /old_locus_tag="PPM_2741"
     CDS             complement(16059..16505)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687469.1"
                     /locus_tag="PPM_RS14300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2741"
                     /product="NucA/NucB deoxyribonuclease domain-containing
                     protein"
                     /protein_id="WP_014599904.1"
                     /transl_table=11
                     /translation="MFRWIFTVLITILLAGCSLQQDVVKTTKSDPVSVPVTQVSADTVK
                     LEFPSAKYPETAQHIKEAIQAGKSPVCTIDREGADHNRELSLKGVPTKKGKDRDGWPMA
                     MCSEGGKGADIKYISPKDNRGAGSWVGHKLDEYKDGTKVEFFVK"
     gene            17118..17624
                     /locus_tag="PPM_RS14305"
     CDS             17118..17624
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPM_RS14305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019687471.1"
                     /transl_table=11
                     /translation="MSKKLSSLFLSFLISVILVVPVSAQSVTPTQDQSSSVENSIQAQP
                     LSVEPSSSQLAPDSSNSNESIQSIIAPVWVTKSFNVTKNGRTVTVEWGIATDSIIREVN
                     ASFKTGAGWTEATSFKGPNTGGVTLSQTWEYSQPGTYTVGGVAQLYTDKGPASCFSPPR
                     VVVIN"
     gene            17655..17912
                     /locus_tag="PPM_RS14310"
                     /old_locus_tag="PPM_2742"
     CDS             17655..17912
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016611719.1"
                     /locus_tag="PPM_RS14310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2742"
                     /product="hypothetical protein"
                     /protein_id="WP_014599905.1"
                     /transl_table=11
                     /translation="MKVIELAIVLNDKEGYYAENFDLVALPFVPRKGEMILWNNKLYRV
                     LDVMYSFDTNPYDYNFDASPSTQSSVAHDITYKVFLKPED"
     gene            complement(18117..18461)
                     /locus_tag="PPM_RS14315"
                     /old_locus_tag="PPM_2743"
     CDS             complement(18117..18461)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPM_RS14315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PPM_2743"
                     /product="hypothetical protein"
                     /protein_id="WP_019687473.1"
                     /transl_table=11
                     /translation="MKKMFISLFLGVLITTGLSVSSFSSFTSVADAKPLRYTVTLHPNE
                     TYQLGYGPGYWYYMGSGKSNDFTVSPRGLIKIYPDPENISVGDGAYAGEISTVDRFGGE
                     VETVTIRIKY"
     misc_feature    complement(18523..18537)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.67"
                     /tool="antismash"
     gene            18770..19195
                     /locus_tag="PPM_RS14320"
     CDS             18770..19195
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPM_RS14320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019687474.1"
                     /transl_table=11
                     /translation="MNGLSLTTIVGIFGAVVGGALGIYFSSYTDVVWLSYIIRLSLAAL
                     FGSLFSFLGWYLNKEGLLVNIFQLINLLVGLLLFYLLFCVVSFIVLSFTPFSKELINIY
                     GTYIPIPLSFLAIIIYIKKKKISFKKSYDTTEDDIYY"
     gene            complement(19240..19800)
                     /locus_tag="PPM_RS14325"
                     /old_locus_tag="PPM_2744"
     CDS             complement(19240..19800)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280986.1"
                     /locus_tag="PPM_RS14325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2744"
                     /product="phage holin, LLH family"
                     /protein_id="WP_014599907.1"
                     /transl_table=11
                     /translation="MQTIIETVQPYVNTIVTATAGVLTAFVLGGLNKLKTKVNVWLDAR
                     TTAAQREVIHKVAGEAFALAQTTFKDAGGIRKMQEALQYASLRLTEQGIVVSPTELQAA
                     IEKAYLEYKARTKAILATEAQPNEKAAQAAAKEAVSGLAAKLNDFLAQATAEVANTVPA
                     QVQSEPGPISAPLEAVQMPVTTE"
     gene            complement(19803..20576)
                     /locus_tag="PPM_RS14330"
                     /old_locus_tag="PPM_2745"
     CDS             complement(19803..20576)
                     /codon_start=1
                     /function="N-acetylmuramoyl-L-alanine amidase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018755216.1"
                     /locus_tag="PPM_RS14330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2745"
                     /product="M15 family metallopeptidase"
                     /protein_id="WP_014599908.1"
                     /transl_table=11
                     /translation="MTITLELVKSKSATRLQGLLPVVRTAAECLIERSFALGIPIVITQ
                     GLRTIAEQNELYAQGRTKPGPKVTNAKGGTSYHNFGVAIDFSLLLPDGRSVSWDTQRDG
                     NADHKADWMQVVAIAKELGFEWGGDWKTFTDLPHLQIVFGLSTAQYRAGKRPTKAQIDS
                     VLSRINKTGDDEPMTLEEKATLKELQKTVQAQADRIKTLETAAKQPKVPTWAEQACINA
                     KAVGVLDTANDGSYDFYRMVTMLDRAGIFETKGDK"
ORIGIN
        1 gtaatatcat tattaagtat ttcgatcaat tcctccacag tcccagagtg ctttacaatt
       61 agttccttgg accaattggt atgtgggtta ttcttcaaag ccattgcttg tgactgctct
      121 tcaacaacca catatgaaga aggggttcct gttgtaattt caatagtttt ccccttcacc
      181 gctaggttcg tccccaaaga ttctgaaatc gggcgcaaag gtacatacgc tgtaccatcg
      241 acggcaatag cgttttcaaa caatgttgtt ccatttacgc tcacatttta ttcccctaaa
      301 accatctttc caactagtgg aaatttcttg gtgatggatc aaatgtagcg ttcacaatta
      361 catcatcgta catatcacct cttagtgaag caacatcgtt tctcaactct ctgattgttt
      421 ccccgagatt ttcaataaaa tcttcaactc cgagcttaag cccacttaca gtagctttag
      481 taaaattaac ctcattttga aaataaacca tattatccgt agattttaat atatccccca
      541 cccatattat ctacatgaaa tgaattcaag tccccaaaaa tacgcctacc ctcttttgct
      601 gtacagaata aggcacctgt aataataccg ccctctatct cattaccaat taacttactg
      661 gctctaataa tcatcttggg cccgtatcgc tgctaatgca tttcctatcc tatatccaaa
      721 ccttaagtat ttctttccgg cgtgctggtt gcgaagcaat gatagcagaa gatagttgaa
      781 aaacagtaat caatctaagg agcatgtcga cctacgcgag gcttcatcct aaatgaaact
      841 aacgcaggtt gtagttaaat tactattgtg ataaactgga tgtaatttga tgatgggagt
      901 tgaacggata catgtagaac tttcttgctt cgagatcacg aaaagaacgg actcagcgat
      961 tggctagggt cgttttattt cgtctctgca agaaaggtct gcgtttcgtt tgcgctccct
     1021 ctccggacag tcatatggcc cccttgtaat ggggtcttat ttcctcgtat ggattagagc
     1081 cgcaagaaag cacctttctt gcggctcttt tttatttcca aacgaaagga tgattgccat
     1141 gcccgccatt caggtaacca atcttacttt tgcctatcca ggcagctatg accctatatt
     1201 cgaaaatgtt cattttcaaa ttgatacaga ctggaagttg ggctttacag gacgaaacgg
     1261 tcggggtaaa acgacgttct taaacctgct gcaggggaag tacgaataca gcggtacgat
     1321 ctccacacca gtcgcctttg attattttcc gtttcccgtc gaacatccgg agtatttgac
     1381 tttagatgtc gtcgaagaga tcgtgccaag ctatgagaac tggaagctga tgcgtgaact
     1441 gaacctgctt aaggtttcag aagacgtgtt gtaccgacca ttcgaatcgc tgtcccaagg
     1501 agaacagacg aaggtattgc tggctgtgct attcatccaa gacaatcgat ttctgctcat
     1561 cgacgagccg accaatcatc tcgatttgca cgcacgcaag cttgtcgccg attatctgaa
     1621 tacgaagcgt ggttttattc ttgtttcaca cgaccgtgct tttctcgacc gctgcgtgga
     1681 tcatattctg tcgatcaaca aaacgaatat tgaaatccaa aaaggcaact tctccagctg
     1741 gtggacgaac aaaactcgcc aggatacatt cgaaatggca caaaacgaaa agctgtacaa
     1801 agacatacag cgtttatcag cttccgctaa acgtactagt agctggtctt tcgagaccga
     1861 aaaatcgaaa aacggcacac gaaattccgg ttccaaactt gacaaggggt acgtcggaca
     1921 taaggcagcc aaaatgatga aacgctcaaa atccatcgaa cagcggcaac acactgcttt
     1981 agaggaaaaa tcgaaactgc tccgaaatat cgaacagtca gaaagccttg cgatctctca
     2041 gctcgtgtat cccaaatcgg aattggcgat actggatcat gttacgattt actacgggga
     2101 aagagcagta tgcaagaacg ttagtctgat gattgaacca ggagatcgga ttgcaatttc
     2161 aggtccaaat ggttcaggta agtctagctt gcttcacctg ctcaacgctg aggagctata
     2221 ctatacaggt acgtttcaac gggatccgca gcttcgcgtt tcctatgtat cccagaatac
     2281 ttctgatttg cgaggtacgc tttccgatta tgcagcagag cacagaattg acgaaagctt
     2341 atttaaagcc gtgttgcgta agctagattt cgcccgcatc cagtttgaga aggatatatc
     2401 ggcgtttagc ggcgggcaga agaagaaagt tctgatcgcg agaagcctat gtgaggaggc
     2461 tcatctgcat atttgggacg aaccgctcaa ctttgttgac gtgatttccc ggatgcaaat
     2521 tgaggagctg ctgcttgaat acacgcccac cattgtattc gtagagcatg atcgggaatt
     2581 tcatgaccgg gtcgccacga aaacgattga actcggtggg gattagaatt ttacaaattg
     2641 aattggatta agacatgatt tcaacgatag aaagctttgt tcaacaactt ttatgaaaag
     2701 gaaaaagatt gaactaaagg cacacgatag ttcaatcgaa catcggcagt ctaggatttt
     2761 attttttcgt ccatggctgc cgatggtttt attgaagaca gtttaatagt tatctcacta
     2821 agactaagaa gcttatatta ttttacagtg ggttttgctt cttctactct actctcactg
     2881 tccattatgg gaaattccgc ttcaaatgct attgcaaaac ggacaacagg atcaataaaa
     2941 tttgatcaag gaagtataag ccaacttgtt ttagctgttt gtgactttta ccagcaacca
     3001 agattacaat gtcgccaaag taatataagt ttggtaatcc cccaattgaa agaaaaaata
     3061 ttgagtgagt tgaatttgta tttgcttaag agtgtagaaa acttatatac agatatggag
     3121 aaagatttat tcgtatctat ttatgcgaac gtaatctatg aggctggtta tttatgggct
     3181 tccggaaaag taaaattaaa caaagaagaa atagctaaga aaatttcgtt attcgtatta
     3241 ggtgggcaga actctcttta atgctgcttt tgctcacttt cttaatattg ctcatcctcc
     3301 tcccaacaga taagaaacaa taaaaaaaca caagcaatta cgcttgtgtt ttgatgcagc
     3361 ctatatcaga tcactctcaa agagacaaga ccctgaaact gtaccacgta aggcttcaag
     3421 ctcatccaga gctttcttta aatcaccgtc catcgctcat atcctatttt cattaagcac
     3481 attcccctct gtacaattca tgattacttt agaataatcc gcaaaaacgt tgcgcttgcc
     3541 atgcaggtcc agtcgcgaaa cagccccggc aatttccgta actcaccgtg tggaaaacga
     3601 cacccccatt gaaaaggatg cctcaacact atgaataaag taacaaattt caggataaaa
     3661 aatcatagtt cctaatgtca gaagaagcca aagtattaga ctgaccttag aaattgaaac
     3721 agcgacaact aagacgagga aatagggtcc ttgattgtcg ctattgcatt gaactaacgt
     3781 atcccgttag ttcaatggat taatatacaa ctaaaatcca aactctgtta ctctttcaag
     3841 ccactcacgc ataagtgact caaataatag agtctgttca atctgaagat tatggcctgc
     3901 tcgatctaga acggcaaagg ttgctctagg ataattgtct aaaattctaa aagcatctat
     3961 gtaaccaaca actgcatctt gtcgcccaag agtaaatact gttggtttat cgaaaactaa
     4021 ttcatctata ttggtggaaa atccatagtt tctttgaatc ttgctaagaa aatcgtagtc
     4081 agcgatctta caacctgcca tgatctcttc tgaatacctt ttccaattat attcattgag
     4141 aacgacttga tttgcgctaa aatcacttac ttgctcttca cttaaggtgt ccataaactc
     4201 gcgatcacta tgaacaacaa aatgctcggg aagtattctt cttttgtgtt caggaataat
     4261 taatgggcaa atcagtgcag ccccaccaat acgatcttta tgtctattaa ttattcctct
     4321 tgtaatatat ccaccgtatg attcacctgc tatgagataa tcttggtttg ggacaagagt
     4381 ttcaataaaa tttataactg cttctagcat atcatctgaa ttacatattt gatcgtaatc
     4441 ctttgtttgt cccattccag gcaggtcaag atagatacga cgccaattgg aattatcttc
     4501 aaatatcggt tccatacacc cactcattaa ccgatggtct ggtgtaaaac catggatcat
     4561 tataattggt ttgcctttac caatttcctc gtaatatata ttggcattct tgactttaca
     4621 atatggcata cagactcctc caaaattgag ttattattat aatattctta cactaaagaa
     4681 gaatctacat gttttatcaa gcaaaccaga tctcctttcc gtttcgtttt gattatatac
     4741 gcatatataa tatatgtaaa gaacacttgt tccctattct tgttttcgga gttaaactaa
     4801 cctgcccgtt acttcaatga aaaaaagcag cccctcatga actgccctac tgctagtcac
     4861 ttcaacaata ggatgagttc atacaagggc taccccattt accaagtaat ccaaccgctc
     4921 gttcgtttgt aactgtgcag gatctcgtat tcctcactac gcatcagtcg tttcattttt
     4981 gttctataca gccgataatc atcttttctt gctactttac attctttgtt gtaatgaaca
     5041 ctcttgattc ctttacggaa atccttaagc ttctcttttc ttggatcttt gggcttatta
     5101 ttgatctcca gactacgctg tttctcatct tcccaggatt gaatctcttc ccgtgtaaac
     5161 atcttcatcc ccgttgtgcc gggttagatt ttggcatttg aagccatgac cttagacaca
     5221 actaatagaa gaagatcttc ggattgaaca ttaaatcacc tctgaattta ttcgccctta
     5281 ttttaacata tttataacta ttcttcccgt tttacgcctt caatcagtgt ttagacaatc
     5341 attttacata tttgaaattt gcaactttcc cctctaaacc ttcctcatcc tggtccgttc
     5401 ctgtttcacc atgagctccc ttctaaaggg agtctttatg cataggtata ctccggtccc
     5461 aatcgttcga taattcgatc caactgtctg gttagataag gcgaaacgtc accaatgcca
     5521 gacactgctt ctaacaaggg aaaggattgc ccaccccacg ggccttgtgg atcaaagact
     5581 tgtctaccga ttcgcaagcc ttctgtttcc ctgaagatgt tcaatcgttc caatccttca
     5641 ataagcagcc cgaccggcag cgttttgttc ctacgtcggg accattctgc caagaaggac
     5701 atgccacgta atatatcata ttcaaaaaac ctcggaaaac aaggcttcag ccattccata
     5761 tcgatgacac ttctattttg tttagaacat acaagacgat gctcaattaa ataacgtgcg
     5821 ccttcatcta agaaaacgac ttcctgttca gtaaattcac ggtctgtatg ccataagata
     5881 gcttcaagcg gaggaagtgt cgaaacaata gagctctttt tagaatgaat ataagcttca
     5941 ggatcgcagt tcagtccgcc atcaggtaac tgatgcttta agagccattc gcgaatccaa
     6001 ggcagttcct tgtccaaatc acagccatac gccattagaa tcatatagta tacggcaagt
     6061 tcacaatggc agcaatccat cttcatctta tcactttcac ttgttggatg gtcatcgggg
     6121 aatatgatga aggtgggcca aacctgagtt tcgagtaaat attttgctcc agtaatagca
     6181 gactcgggaa ttagtttcac ctcacccatt tcataaagag cagccatatg ccaccaagct
     6241 ccatcccatt ttcgacggct gcactcgccg tgagtcatcc ccaaatgcgg agtagattca
     6301 aggaactgta tagattcttc gattgctaaa cgaatatttt gatttgcttc catctgggta
     6361 tctccttttt gattacctct acttcacact tcagttaagc aacgcctcac ctcgtatacc
     6421 cttccactct taaaaaattc gatatgttat taaactatcc tgcccgttag cttaatgagg
     6481 catcgtcaga atattacttt atttttcagt ttagaacttt attttcttct gacacctata
     6541 ataaagaccg caaaggctta agccctttgc ttctggcatt ctaagtccaa tttctccttc
     6601 ttggtttcgc ccccgaccat agtcgatcat cacaaaatcc aatgttcggt tgacagactt
     6661 tttgctaaat tttctttgac cttgcgtctt ttgtcagcga atgttgtggc tgatatacca
     6721 tgaatacctt ttttatactc tgctcatata ctgttgagct tttagataca aaagctttgc
     6781 agcaagcctt tcatgcacat ctctaatgtt agagattgca aaacggatat tgtttgtaat
     6841 gaggaaatag aacttgtaat gagctgttac tctttagagc tatccacatc cagaatgcca
     6901 cccaagggtg agccatcatc caatcagctt atggtcatga gcggccacgc tccacggaat
     6961 cgcttatact cttctgttct tttaggctgt aatagctgag ctcatgttca ggttgcacac
     7021 actttgacct tttattgtcg tggtaaccgt agaccttcaa cagacttctt gagcctggct
     7081 atctcgttat ccttttgttg cataagggtt tcaacggcga ttaaatcatc gttctagccc
     7141 ttagccacct gttgaaatct ctataccccc tttctatatc tagctgctgt ggtgggtctg
     7201 gatcaatcct tccactattg aatggttgtt gctccacatc tcatttatat gtttttccac
     7261 actcatccgc cgtctcggct ccatccactc tttgcagcat caaatggcat tttacagtca
     7321 tatacaatta aaaatccctt tccgcattac tgtaagtaca ctgtccgaat gcgtacatgc
     7381 ctcttctttc atccgtagga gtatttttaa aatcgaaatc aacattttca gtgaggaaga
     7441 aacctctaca tctggcatca ttacaacgat gcttcgacag acattgtata aggctgtttt
     7501 ctctttcttt actccctatg agctaaaata tgatatatcc ttactgccct caacaatgaa
     7561 tatgttctgc ataaactatc aaaaaggaga tgagaacatg actagattgt tagatgctcg
     7621 aacatctcaa aacgcaagtt acggtaatac gatctcaatt cccttgccag ccaatactgc
     7681 tggtgccatc gcggagcttg gtttagatgt aacggaatgc cctttactct gtgagtgtct
     7741 ccgaaacaaa cccaaacgct gtacaagtcg tcaccatcaa tgcttctgat tacaatatcc
     7801 ctctaccacc atcaaatgaa ttggtatata ccttatatat attttgcaca gcagatgcta
     7861 cccgaatagg aatagaaagt tttaatgctg ttgcctactc ggattaaaat tcaccgtaac
     7921 acggagaaca aagccctctt atttttgttt catctgctct tggagacaat aatttctatc
     7981 tgtcgttcat tttttggtat aatttactta aagggggtga tcaaatggga attatgctta
     8041 ttcttattgc tattgttttt ttcgcgcttg gtattttaag taaacggaaa cccacttggg
     8101 gatggcgtgc aaacgaagcc tggaaaatca aaggtgactc agaaccaagc gacgcttaca
     8161 ttgatgacat gaaatttagg ggctctgtat ctattctctt tgggttcttc ttcttagcat
     8221 gtggactttt ggttatcttc ctgtaagcgc acttccttaa acttcaaagc tcgaccagcg
     8281 aatgtagtag tagttccata actagcttta tagatttcat acttttcttt ttttgtttct
     8341 aaacacttct tcgcgccctg ctggcgtttg tattctttcc agtctacttc atgaaaccaa
     8401 aagtattttc cgtagctatc cctataggtc tctatacaga attgaagaag ttccttcatt
     8461 gatttgtatg tatctgctca tggcatggat cgaacatgcc aaggcattta tctttacacc
     8521 gtgtccgctt ctaactattt aaaacctaat tcaataattt tttgtgggga aattgtgggg
     8581 agtactgcgt agtccaagaa aatgaagcat tatcctcaaa caaaaaaatc cctcaacgct
     8641 tagagcgcca agggattcca cattttagta aagcgtcaga tattgatcac gttcccattg
     8701 atgtacttgg gttctgttta tgtacgaatt tatcacttca tcttttcctt tattaggata
     8761 gcgatttata gaacatttca tcagaaacgt tgttcacaat ctatcataac ttttcatgaa
     8821 ttgggggacg tttgggggac acttaggggg acgattttaa gaccaatgta gggcagatgg
     8881 gaatgaacca ttctaccccg ttttacatac tactttacga aagtgaattc atgaatccat
     8941 gaaggagctt ctactattac aacgaccggc agagtagtcc caaatacctg aagcatagat
     9001 aaggtataaa tttcagcatt ctctttttta atgtcccatt taatctttaa tctgtgtatt
     9061 tgcattgatg cacgtccttt gtcgtattta ctggagtgcc tctcagtgat ataatttgca
     9121 acgaatagat gtctactgga ggatctctga ttgaaaatct cccgtgggag atgccgactt
     9181 aaggagctac tcgaagaacg tcgtataaaa caaatcgatc ttgctagacg caccggctac
     9241 agcagacatt tgatttctaa ttgggccaac aatcaggata aaatgtctgc tgatgttatg
     9301 attaacatag cttatgccct cgattgtaaa atggaagact tatacgaact gatctttgag
     9361 tgagcctgtt ggctctccct cggataaaag tatggttgaa ccatactttt tacagacaac
     9421 tgtactcccc tccctttttt attttccaag tcaattatgt ctataatcga acatatcaat
     9481 ttttgacata actatactac tattaaatcc cattattagg ggcttggcaa caaaaattcg
     9541 ggcgctgaat gtctcttaat attcgacatt ataagacaaa aaaagagtcg ctattttgta
     9601 gcaactccag tgaagattat tttcgaatta ataaaaccca tttcttcaac aacctcatca
     9661 aatcgatggt aagcaattgg acaccttttc gatgtttttg ttacttcatc ttcaaagtaa
     9721 gcatctttaa agataccatt aacaatcttt actttttcta cattaagagt gttgcttcta
     9781 tccacattta aaaaacgata tccgttacta ttcaaaaaat tctcccaatg tctcaaggtt
     9841 cctaccatat agtatgtttt atcaaatgta tgaaccagta tctggtctcg ctttctcccc
     9901 ttagagatga aaaggacttt gtctactaaa acattttctc ctctttctat acctccagga
     9961 tctgccgata cggttaaact tagcatttaa cattccccgc ttactttaac aattctttcg
    10021 gtggttcggg actgtgaatc catgacagac ttgccgtgct cactgatgca actgcaagta
    10081 ttgtcaacat tgcagcaata ttgtaataca tactagcctt cactttactc ggtttggttt
    10141 tcttcatttt tcacacctcc ttctattagt gttaaactct gaacaaaaaa actggcagct
    10201 accactggaa aagccaacca cagatttaga gcaacaattg caactcccat aaactttagc
    10261 aacggatagt gcttctttga tatacgcgtc ttcccctcca ccctcgatgg cgcgtaaatc
    10321 aagataagca caatacttat tatcgacgta ataacgatcc aattgtaatt aaaacttgcg
    10381 aaagataaag cagtaagtag aactgtagat acaacaatac acactatatt gctctttaaa
    10441 tgtattcctc ctacaatttg gcgcaacatt gaaaaagata tcatagctag caaagcttcc
    10501 tgcattctgt ccgtaaaaaa tgagatacct atagtcagta aaataattga gactgtattg
    10561 atcgcaacgg atatcccgtg ttttagaaca tctatagatg aaggatgatc agggacaact
    10621 gttttgatgt gagtcgcaat attaagagcg atggtgtcaa ggctttttat agtaatcacg
    10681 ctccgttttt aatgcataat ataaaaacat ggcagatgct aaggcaataa atagaatact
    10741 caagaagaaa ttattgacgt aaaacataaa tgcacaagct gccaatactc ctattattaa
    10801 gataataacg agtacatact cccacttaaa acgtagattt tcataatctg ccgtaaagcc
    10861 tattttaaat ttatacagga accacgaaat agctaacacc catgcactag ttaccgcttg
    10921 cgctaacgat ccttctgctg aggtctgcat ttctgttgtc aaggtaccaa aaagcattaa
    10981 tataaccgcc gcttggaata atgtgtacaa aaaagtgcct gtaatggata tgatggctgc
    11041 ccaaataatc ggcatcctaa caacagtggt tattaataac gtgaacaata taatgtttat
    11101 ggttggagca aagaaagata aagatgtctc ttctctcaag ataaagctct gcaaattcat
    11161 tatcaatcca ataaacaatg caggccatat atagtctaag gctctaactc taaaaatagt
    11221 taacattaaa acaaacgccg caaatgtttc tacagtcgag aaaagcaaga accgtacagg
    11281 ctcccacata acacataacc ccttctcata attggtaaca aatatgcttt aattctatat
    11341 ttgttacttg ttagaggcaa tccaattacc atgttaaatg gaagtattta tgtattatgt
    11401 gaggtaatta ttttcagcct gccgatataa tatcctcaag cctaatccaa ctaaagtcat
    11461 cttccccacg aaacagtttt acttcgcgtc tagcggtgtt aattgacgtt actacaccag
    11521 tcatgtccgt atcgtcaaac gggctaaata cggtcacgct gacaggctgg cgtgagttgt
    11581 aagagtctat taaagcctgc tcaatcaatt gtacttcctg gtcatccaat tctggtttac
    11641 cgcgccgttg acggtctttc ataagtttta agtatccttc tttatgttcg ggcaaaatga
    11701 tgcgtgaact ctcccataaa ccattaccct caagtctctt tcccatttat gtagcctcct
    11761 gttgtgttct cctgatgtgt tatgtagaaa ttatattccg aacacttgtt ccttacaagg
    11821 gatatcattt ccagtacgca aaaaaataaa cctcagatta tccgaggttt aatattccgt
    11881 aaaatatcta ttcgcatcac ccggcgacat cggtctactt cgtccgcgct cccagccctc
    11941 tataataacg atatgccgcg tatctgactg gtcttcccat gtaatataat tgtcactctc
    12001 caaggacaac agacccgact ttatgtcctc tacactccta cctgtcttaa tctccaattc
    12061 ctgcattgta ggcatacgcc gctgttgtgc aaaaaaatta taaagtatcc ttaataactt
    12121 acgttcgatg tctgataaca tgtatgatca ctcctctgca attattatat gcaaacaagc
    12181 gttcgttatt caacataaaa aaatgctccg ctggcagcct aattgccagc ggagctagta
    12241 ctttctttgg cacttacggg cttaaaataa acacgcctac agagtgccat tacatcttaa
    12301 tcagcattta caatgcggaa atcaagttca attcaaacac tcacatagag tgcagcttta
    12361 cggttaggtt actaaataat ttgagtttac ttactttgca gtagggtaat ctttaacacc
    12421 tagtctttcc ttaagcgcgt gctgtaacac ctgtgaaaag ttaattttct cacgagtagc
    12481 ttcccgctca agccagcgtg gaagtgtgac atttttggtc actgctttgt tcatcatttc
    12541 gtccctgatc gtccccatcc ttatctcgat caaagtgatg aaagaatcgg gtggcaattg
    12601 aatgctcgct ggatcagaag ctggcggaat cacttcgttg tcctcttcaa ggccaaacaa
    12661 ttgcagctct aagcactcct tcgccattcg caaagcctca gacatatcat cgccttctgt
    12721 tatcgctcca ggaagatccg gaaaagtgac tgtgtaacct ttcacttcac ccttttcaaa
    12781 tattgcaggg taaatgtatt tatccatata tatgaacctc cttttgaggg gggctattta
    12841 agccccgcct gtttgagtat tgtgtctgct gttttggggt caaggtcttt tcttggatgc
    12901 ggtactgtga cgagacccga cttagtagga tgtttgaatt gatgatgact ccctctaacc
    12961 ctagctaagt accacccatc tgcttcgatt atctttatca tgctacgtga tgagtagttc
    13021 aaatcatatc ctcctctcta tatttattat aacacgcata aaatatgcac gtcaataaaa
    13081 tacatgcata ttttatgcgc atggctttaa taacaaatga tccttcttaa taattaaggt
    13141 tagcaggcct tttcctctcc aatacttacc gcctcactac ttcataaatg agcgttataa
    13201 ttaatctgag gtggtctatt tgtttatttc tccaatgtta cttgaaacag cggctgcccc
    13261 cttttcggat tcgcgctata tcttcgaacc gaaaatagac ggccaccgct taatatattc
    13321 gcaacagaac ggcattgtac gcttattcac gcgccataac aatgactgca cacgccaata
    13381 cccggagata gctagcgtta cattcccgca tgacattgtg ttggacggtg agattgcgtg
    13441 cgttgatccg acaacgggtg tatcggattt tgaatccgtt atgtcccgct tccaggcgag
    13501 gaaaacggac aagattacta agctcgtagc tgaattaccg gctactttcg ttgtcttcga
    13561 tgtcttgagc tttaaaggcg aggacttgcg gagccttccg cttatggaac gcaagtccat
    13621 actcgctagt ctaacgcttc ctagccctag tttcggggtt gttccgtata ttgaaggcgc
    13681 cggggaggcg ttgttcgagc agatagaagc gcgcggcatg gaaggcctgg tcgccaagcg
    13741 taaggatagt atgtatatca gccgccgatc agcgtcctgg cagaaggtca ttaactggtc
    13801 ctatgccgat gtgtacatta cgggttatcg taaagaggaa ttcggatggc ttgtatcagt
    13861 gcctaatgag cgcggtaacc ttcgtcccgc cggcattatt gagcacggag ctagcccaat
    13921 gcacaagaag gcgttctatg gcgtcgtggc accgttaaag accgatgagg atcgcgaatt
    13981 tgtttacgtg gagccgcgca taagagcccg tgttaaaatg cgaaactgga ctaaggcggg
    14041 taacttgcgg ataccagtat ttacggaatt tatagtttaa acaaaagaaa ttcccgccga
    14101 ccaattaagg ttagcgggga tttttgtcta ctctaaattc aaattggttc cgtatgtaat
    14161 aagctccagc aatcttaacc gaatcaggcg aaaacttttc tatagtgcca ccatagtcta
    14221 caaccgatat aaaatcctcg cctaacgact gaacaacgta cacctttacc tggcttaatg
    14281 cagctgcaaa tagttctata tctgacttta acactttata tgtatggttc atgttgatca
    14341 cctcagaata ggttttatga gatattcttc gttgtaggta atctgtaacg gcttttccat
    14401 attaccgaac atttttctta acagcctcag aatgtgtact caatagtaat tcctgctggc
    14461 aattctggcc ggtggtcatc ccatcttttc gtagatcata acatgggtat gtttaattaa
    14521 tgattttact aggctatata atgagcagaa gaaaagcacc tatataggtg cttttcaaac
    14581 agaaagcaat tctcaacgat caaaatccct cttaatattc aagctataac caagtccttt
    14641 accgttacca ccccaagccc catcatgacc tatgacttta aaatagatca catccccagg
    14701 gagcaggcca ctagtgccac agacatcatt cttcccttgt ccattgtctt gagcttcaag
    14761 cacctcttct tcacctttat caggatagta agcaactata tcataattga tatattgttg
    14821 actttttaaa gtggcaattg ccgtcatttc tttgcttctc gaagtattta ctactttaaa
    14881 ccaatctaca tcatttttgt ccagatatga tccaaaatta aagttactac tttgtacatt
    14941 taaggctgtt tctctagtgt cattctgacc agatattgcg aaagcacttt gcgacaatgt
    15001 caatgtcaat gtcgcagcaa aaaggactga taataccttt cttattttca tgtttattcc
    15061 acctttcgtc attataaaga atcagccgat tcgattctat tttattacat atcatattaa
    15121 gatttgagac gcgcttgatt tacaattatt gatattttgt agattattta ttattatttg
    15181 cttcccattt ttagtctata aactgcatca aaatctgacg gtctccattc ataattaaca
    15241 ttcccttctt tccaggttgt atgaagtatg agttttcttt cctggccaga ggcattttgc
    15301 ttataaccaa caataactag agcatgtccg ccttctattg atcttctatc atcttggtat
    15361 cttttcattg ttagccaaag aggtctacct gcattaattt cctctgttat cagattccaa
    15421 gctttttctt gtgcagagtt tgtggcaaaa ccatagcccc caaatgaata tatgtaccct
    15481 acatcatcta aatatctagc aaaggcattt actgctcgta cgaagggcac gccgccatct
    15541 ttgtcaggat ggaaatattt atctgccaaa atatcttgta gttcatcatc tgatacgcca
    15601 cggtcaatta ataatggata tccatgactc tcccaatact tgataatcat agctgccgat
    15661 gatatggtac atcctcttcc ccaatcgaag tcgggcacgt ctgaaattct tttcagtcca
    15721 ataatacttg gggtaataac ttgagtaata tctggagtag tagattgagt ggaataagta
    15781 gagtccgtaa cagtggttac ctgatcagca aaggcagcgt tttcaggaag taaacctaca
    15841 acaacagaac caagcaaagc gggaatcata atttttttaa gcattttgat cctccatttt
    15901 tttggtatta tattcaatac atttccataa tatagaacat ttcgcgattc aactgtgatt
    15961 gatttcacac aacactataa tctatttaca tctaacctaa attcaaactg atcaatgaaa
    16021 aaagctctgc caaccaatca aggttagctg agcttttgct atttaacgaa aaattcaact
    16081 ttcgttccat ctttatattc atccaatttg tgacctaccc acgatccagc tccacgatta
    16141 tcctttggac ttatgtactt aatgtctgca ccctttccac cttcggaaca cattgccata
    16201 ggccatccat ctcgatcctt acccttcttg gtgggtacac cctttaggga cagctcgcga
    16261 ttatggtcgg ctccttcacg gtcaattgtg catactggtg attttcccgc ctgaatggct
    16321 tccttgatgt gctgggccgt ttctgggtac ttggctgacg gaaactccag cttgaccgta
    16381 tcggcagata cctgcgttac cggaacggat acagggtcgc tcttagtggt ctttacaacg
    16441 tcttgttgta ggctgcagcc agctaatagg attgtaatta gtacggtaaa tatccaccta
    16501 aacatatgta aacctcccta aacgtaaaac accccaccgg cttgagccag cagagtgcta
    16561 ccgatgcttt cggattataa gataagtata attgttttgg gtgattttgt aaatgcaata
    16621 tgtatggttc atactgaaag cctctgcaaa tattatatgt aaacaagtgt tcgttgtcca
    16681 aggcaaaaaa agagcagtta gagttctatt cctcctgccc ttttctgttt tcgatctggt
    16741 gcatttcaat tactcttgat cctttggata ctttattagg gtggctatag ccaccttcaa
    16801 ggctcaagct ccaattgaat tgagctattt agcacggggc tgaatgaatg ctgctaaaaa
    16861 tgtggatgcg actccaagct gaagcccaag catccggaac gcggcagctc tctccgattc
    16921 gaacgagatc cacgcagcgc tatagcgccc actggcgtca cataggcgtt gttgacaaaa
    16981 atctacaact ctatttaata gaaagatgag gttacaatga tatggaaaat ataacctata
    17041 tgttccatca atagtttact tcatccttat atttaaggat ttagtataaa aataatttgg
    17101 aagaggtgcg tattaaaatg agtaaaaaac tgtcgtctct atttttatcc tttctaattt
    17161 cagtgatatt agttgtcccg gtatctgccc aaagcgtcac ccctactcaa gatcagtcct
    17221 catcagtcga aaattctatt caagctcagc ccttatcagt cgaaccatct tcttcacaat
    17281 tagctcctga ttcctcaaat tccaatgaaa gtatccaatc aataatagcg cctgtgtggg
    17341 taaccaaatc gtttaatgta actaagaatg gaagaacagt aacggtggag tggggtattg
    17401 caacggactc aattataaga gaagtcaatg cttcttttaa aacgggagcc ggttggacgg
    17461 aagctaccag ttttaaaggg ccgaatactg ggggagtaac tctcagtcaa acatgggaat
    17521 acagtcaacc agggacttac acagtcggcg gagttgctca actttataca gataaaggac
    17581 ctgcatcttg cttttcgcct ccaagagtag tagttattaa ttaaagagta tttctacact
    17641 tgagaggtga ggaattgaaa gttatcgaat tagcaattgt attaaatgat aaagagggct
    17701 actacgctga aaatttcgac ctggttgccc tgccttttgt cccaagaaaa ggagaaatga
    17761 ttttatggaa taataaactt tatcgtgtgc tagatgttat gtatagtttt gatacaaacc
    17821 cgtacgacta taattttgat gctagcccaa gcactcaaag ctcggtagct catgatataa
    17881 cctataaagt ttttttgaaa cctgaagatt aaacagacat taaataaagt attttcttag
    17941 cctaagcact aagaaaatac tttatttgtt tttagcaata gcacccccta taaaacagaa
    18001 aaacacccca ccagcgtatg ccagcagggt atcaccgatg ctttcggatt gaagagcgtt
    18061 gttttcttac gtgtgaaatt gtttataaac gaaaataaga gttattagat acaatattag
    18121 tatttaattc taatcgttac tgtttccact tcaccaccaa atctatcaac agtcgatatc
    18181 tcaccagcat atgctccatc tccaacagaa atattttctg ggtctggata tattttaata
    18241 agccctcttg gggatactgt aaaatcattt gattttccac tccccatgta gtaccaataa
    18301 cctggaccat atcctaattg ataagtctca ttcggatgaa gagtaactgt atacctaagc
    18361 ggttttgcat cagcaactga tgtaaaagaa gagaagcttg atacagataa accagttgtt
    18421 ataagcactc ctaaaaataa tgaaataaac attttcttca taataagtcc ccttttctca
    18481 gatataggct tactataatt taccacagat gaatttgtca agaattttct ggaaaataaa
    18541 tttaaggctt cataaataaa agacacccca ccaacttgag tcagtaaagt gcccctatgg
    18601 gtttaaattg cacaatggtg cttccttatg tgttgttatc agtataattc gtatggtcta
    18661 tattgtgaat atatatagaa aaaatttcct aggcctgata gactatatca aaaacattgt
    18721 aatctatgga tattaaaaag gttgattatt tgagaaagga actgcaaata tgaacggttt
    18781 atcacttact acaatagttg gaatttttgg tgctgttgtt ggaggagctt taggtattta
    18841 tttcagttcg tatactgatg tagtatggct aagttacatt ataagattgt cactcgctgc
    18901 cctgttcggc tctctttttt cttttcttgg ttggtaccta aacaaagagg gtcttttagt
    18961 taacatattt caacttataa atttattagt aggactatta ttattctatt tattattttg
    19021 tgtagtttct tttattgtgt tgtcttttac acctttctct aaagaactta taaatattta
    19081 tggaacctat attccaattc ccttgtcctt tttagcaata ataatatata taaaaaagaa
    19141 aaaaattagc ttcaaaaaat cgtatgatac aacagaagac gatatatatt attaaaaaag
    19201 ctaccctacc agcaaaagcg gtagggtatt tgctttacct tactccgtag ttacaggcat
    19261 ttgaacagct tctaacggcg ctgaaatagg tccaggttca gattgcacct gagcaggaac
    19321 agtattggct acctctgctg tagcttgagc caaaaaatca ttaagctttg cagccagacc
    19381 agatacagct tccttagctg cggcctgtgc tgccttctcg ttcggctgtg cttcagtagc
    19441 cagtatcgct tttgttctgg ccttatactc cagatatgct ttctcaatcg ctgcttgaag
    19501 ctccgtaggc gataccacaa tgccctgttc tgtaagtctc aaggatgcat attgcaaagc
    19561 ctcttgcatc ttgcgaatcc cgccagcatc tttaaacgta gtctgagcaa gtgcaaaagc
    19621 ctcccctgct actttatgga ttacctctcg ctgtgccgct gttgtacgtg cgtctaacca
    19681 cacgttaacc ttagtcttga gtttgttcag acctcctaaa acaaacgctg taagcacacc
    19741 cgcagtggct gtgacaatgg tatttacgta aggttgtaca gtttcgataa ttgtttgcat
    19801 gattatttat cccctttcgt ttcaaaaatc cctgctcgat caagcatcgt gaccatgcgg
    19861 taaaagtcat aagatccatc attagctgta tctagaacac ctacggcctt ggcgttgatg
    19921 caggcttgtt cagcccacgt gggtactttg ggctgtttgg ccgctgtctc cagtgtcttg
    19981 atgcggtcag cctgcgcctg cactgttttt tgtagttcct tcaacgttgc tttttcttct
    20041 agtgtcatgg gttcatcatc tcctgttttg ttaatcctgg ataaaactga atcaatctgt
    20101 gccttcgtag gccgcttacc tgctcgatac tgtgctgtgc tcaggccaaa tactatttgt
    20161 agatgcggca agtcggtgaa cgttttccaa tcgcctcccc actcaaagcc cagctcctta
    20221 gcaatagcca caacctgcat ccagtccgct ttatggtctg cattaccatc tctttgagta
    20281 tcccagctta cagaccgtcc gtcaggcagc agtaaggaaa aatcaatagc cacaccaaaa
    20341 ttgtgatagc tggtcccgcc tttggcgttt gttacttttg gtcccggctt ggtccgtccc
    20401 tgtgcgtaaa gctcattttg ctccgctatg gtccgtagcc cctgtgtgat tacgataggt
    20461 atacctaaag caaaggaacg ctctataagg cactccgcgg ctgtgcggac gacaggtaaa
    20521 agtccctgta aacgcgttgc agatttactc tttaccaact ccagtgttat tgtcactacc
    20581 gtttccccct tttcctttca atacctcaac cgcttgtcgg atcactggtg gaattggcgc
    20641 tccaagcctg cccccgtttt ccagaatcga aagcagctc
//
