LOCUS       NC_017542              20549 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Paenibacillus polymyxa M1, complete sequence.
ACCESSION   NC_017542
VERSION     NC_017542.1
KEYWORDS    RefSeq; complete genome; complete replicon.
SOURCE      Paenibacillus polymyxa M1
  ORGANISM  Paenibacillus polymyxa M1
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Niu,B., Rueckert,C., Blom,J., Wang,Q. and Borriss,R.
  TITLE     The genome of the plant growth-promoting rhizobacterium
            Paenibacillus polymyxa M-1 contains nine sites dedicated to
            nonribosomal synthesis of lipopeptides and polyketides
  JOURNAL   J Bacteriol 193 (20), 5862-5863 (2011)
   PUBMED   21952539
REFERENCE   2  (bases 1 to 5864546)
  AUTHORS   Blom,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2011) Cebitec, Bielefeld University,
            Universitaetsstr. 25, D-33615, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 01:49:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,687
            CDSs (total)                      :: 5,531
            Genes (coding)                    :: 5,427
            CDSs (with protein)               :: 5,427
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 45 of 104
            Pseudo Genes (incomplete)         :: 71 of 104
            Pseudo Genes (internal stop)      :: 16 of 104
            Pseudo Genes (multiple problems)  :: 23 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:14:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3027952
            Orig. end                         :: 3048501
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE577054.1.
            Accession number for plasmid pPPM1a in this genome project:
            HE577055.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20549
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="11"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20549
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20549
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10549](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10549)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    complement(996..1010)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
     misc_feature    2828..2841
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.31"
                     /tool="antismash"
     misc_feature    3050..3064
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.3"
                     /tool="antismash"
     gene            complement(3186..4358)
                     /locus_tag="PPM_RS13330"
                     /old_locus_tag="PPM_2562"
     CDS             complement(3186..4358)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371417.1"
                     /locus_tag="PPM_RS13330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2562"
                     /product="M20 family metallopeptidase"
                     /protein_id="WP_013371417.1"
                     /transl_table=11
                     /translation="MLEKWVQELKDGEQELIAWRRYLHQHPELSFEETNTSAFIADQLR
                     SFGIEVRTNVGGNGVLGFLEGGQPGRTIAFRADFDALPIQDEKDAPYKSTVPGVMHACG
                     HDGHTAALLGVARVLSHHRETLKGKLVFIFQHAEEKPPGGAKFMIEDGCLDGVEAVYGI
                     HLSSEIPLGKIGLKSGPAMAAADAFSIEINGKGGHGARPHQTVDSIVIGSQIVNGLQQV
                     VSRRVDPTESAVLTIGVFQAGTAFNVIADKAKIEGTVRTFNKDIRKEVENEIRSIVKGL
                     TDAYHAGYEIDYLNGYPALVNAEAETERVRELVSRLYGADAFMDLKPAMGAEDFAYYLE
                     QRPGAFIIVGARNEDERTHFAHHHPRFDFDERALLISGHIFLALALEYLQ"
     gene            complement(4587..5096)
                     /locus_tag="PPM_RS13335"
                     /old_locus_tag="PPM_2563"
     CDS             complement(4587..5096)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /function="predicted acetyltransferase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017427739.1"
                     /locus_tag="PPM_RS13335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2563"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_014599807.1"
                     /transl_table=11
                     /translation="MGYNIKSELKLSIKSVPESQKDIIVQLMQFYLYDFTAYLRIDVTE
                     KGTFPAYPDLYQYWTSDEQKLPFLIWRQDIPVGFALVDRMSSNREADYYMAEFFVLRPY
                     RHNGVGTWAAHELFGRFNGRWKVTQMSTNRPAQSFWRKVIGSYTNGEYREQTHPVRGNI
                     SQFFNT"
     misc_feature    5080..5096
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.71"
                     /tool="antismash"
     gene            5206..6306
                     /gene="xerS"
                     /locus_tag="PPM_RS13340"
                     /old_locus_tag="PPM_2564"
     CDS             5206..6306
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene="xerS"
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687399.1"
                     /locus_tag="PPM_RS13340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2564"
                     /product="tyrosine recombinase XerS"
                     /protein_id="WP_013371419.1"
                     /transl_table=11
                     /translation="MNIQKIIDRRKLDEKLPDLPWYVQQFMDYKLPDLSPSTLLEYVRD
                     YEAFFSWLRSEGLSAGETNAQVTLEELETLHMDSITGFRLFLSTKREGSNSRITISRKL
                     SSLRSLFHYLSQIAEDENFYPLLKRNIMAKVEIKRVHKPKDTAAKLKGKILEEEELLEF
                     IGYIYEGYGQDLADNKQALYSYELNKERDACIASLILNSGLRVSEIVNLNMDDLDINNK
                     LLYVYRKGNNDETFKTPVYFREQSKDDLALYLSLRHTRYRAPKKEKALFVARPNGSTEG
                     KRMTKRAIQAMIIKYAKRFGKPYLTVHKLRHSFATDYYLQNDIYKTKEQLGHASTETTE
                     VYAHLTDKTMSQAIERRIETQTDPAD"
     gene            complement(6315..6866)
                     /gene="mobB"
                     /locus_tag="PPM_RS13345"
                     /old_locus_tag="PPM_2565"
     CDS             complement(6315..6866)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006777 - Mo-molybdopterin cofactor
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="mobB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371420.1"
                     /locus_tag="PPM_RS13345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2565"
                     /product="molybdopterin-guanine dinucleotide biosynthesis
                     protein B"
                     /protein_id="WP_013371420.1"
                     /transl_table=11
                     /translation="MKTKHPFVCQIVGFKNTGKTTFLGGLIRYVQQSGLRVAVIKHDGH
                     EFEMDHEGTDTYKHRQAGAEGVAIVSAGRTAILEEHSRPVTGLIRHFQAYDCVLLEGFK
                     QEKYPKLVMVREQSDARLVQELTNVQGVVVWECHMDWAQDYYSDEQTVQIYPADASDPA
                     GRWLLEQIQRHRAGFQTEQG"
     gene            complement(6863..8140)
                     /gene="glp"
                     /locus_tag="PPM_RS13350"
                     /old_locus_tag="PPM_2566"
     CDS             complement(6863..8140)
                     /GO_component="GO:1990586 - divisome complex [Evidence
                     IEA]"
                     /GO_function="GO:0061599 - molybdopterin molybdotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006777 - Mo-molybdopterin cofactor
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="glp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371421.1"
                     /locus_tag="PPM_RS13350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2566"
                     /product="gephyrin-like molybdotransferase Glp"
                     /protein_id="WP_013371421.1"
                     /transl_table=11
                     /translation="MNQTPLNTEKFQRKAVKVEEAQSRIASYVQQSEREDVGLEQAHGR
                     YLAMDLTAPHPYPRFRRSGMDGYAILASDTEVCSTGQEIWLHVIDEIPCGTVSDKRVET
                     GMAARIMTGAQLPEGADTVVMLEATQLREENGQTYVGLKKRMEVGKNVTQIGHEIKEGQ
                     LLLSKGTCVGAGHISVLATFGVHRVPVYRKPRVAVFSTGSELLAVDEPLQPGKIRNSNT
                     YMLASQIREAGGEPFILQAIHDDLNLARASVREAIATYDIVVTSGGVSVGDFDIMGDLV
                     RQEDVNMLFNKVTMRPGSVTTAAVIDGKLLFALSGNPGACFVGCELFVRPTIQMMLSSV
                     HPYLQTWTAKLGADYTKVNNYTRFVRSSLEIRGGQVYAIPARVDESSAMVTIKDSDCLI
                     VVPPTTEGLREGEEVHVLVLQGGQVT"
     gene            complement(8344..8583)
                     /locus_tag="PPM_RS13355"
     CDS             complement(8344..8583)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820734.1"
                     /locus_tag="PPM_RS13355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_016820734.1"
                     /transl_table=11
                     /translation="MVADKNENVTCTSFYTIKMARLASGYSELIACNILGMSMNELKHI
                     EEDSSDLTIARAQQMSSLYEVSIDSIYFGKNNIT"
     gene            8672..8887
                     /locus_tag="PPM_RS13360"
     CDS             8672..8887
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024835.4"
                     /locus_tag="PPM_RS13360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_016820733.1"
                     /transl_table=11
                     /translation="MQKLTRGKCLLKEELKSHGRTQSWLARRTGYSRQQISNWIAGRDK
                     MSFEAAVLISRILECKAEDLYEWELA"
     gene            complement(9157..9891)
                     /locus_tag="PPM_RS13365"
                     /old_locus_tag="PPM_2567"
     CDS             complement(9157..9891)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820732.1"
                     /locus_tag="PPM_RS13365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2567"
                     /product="hypothetical protein"
                     /protein_id="WP_013371423.1"
                     /transl_table=11
                     /translation="MEEGKRILATPLLDDNSLGDCSFFCENHLVAIELWKPKSNYHIPL
                     FHTSHGRFTVPTTLHECSVGLPTFCNLDGSNLVNITQVDKIVTGDYGGGQVVFKNQDIK
                     ESINSANLSRWKQIYADAMNADREIRYIFGSEIKVVGKATVSGFFKVGNMLSVDMWEPK
                     KNYYVPRFHSGDRSYTIGLTAQACREAFPYLYPAYKDTLINLDLVCEIESNAFGGLVRF
                     EGSDFTCSMSHNKLKALKKLWK"
     gene            complement(9897..10028)
                     /locus_tag="PPM_RS30405"
     CDS             complement(9897..10028)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017427735.1"
                     /locus_tag="PPM_RS30405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_013371424.1"
                     /transl_table=11
                     /translation="MDKKLARVLSISLGKYANESTKKEKTIFGAKPVPAELKKTEKN"
     gene            complement(10001..10549)
                     /locus_tag="PPM_RS13370"
     CDS             complement(10001..10549)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009372 - quorum sensing [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.4"
                     /locus_tag="PPM_RS13370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_043885981.1"
                     /sec_met_domain="AgrB (E-value: 2.3e-20, bitscore: 70.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLETLSRHIASEIKKADPDGPTSVEVMEYAIGIKITEISAVLMVA
                     VIAWITGHFWGALLALATIMFVRRFSGGVHFSNLTLCVCFTTAICVTIPFVSLGLSTIL
                     IINACSLLVFVVYAPNHFIYINKTKYHKYYKTICILVCILNFFVQSHIICLSIVIQAFS
                     ILPLWKGGERKWIRNWREF"
     gene            complement(10500..11213)
                     /locus_tag="PPM_RS13375"
                     /old_locus_tag="PPM_2568"
     CDS             complement(10500..11213)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820730.1"
                     /locus_tag="PPM_RS13375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2568"
                     /product="hypothetical protein"
                     /protein_id="WP_013371425.1"
                     /transl_table=11
                     /translation="MLSAFLYISLGFFDALAAVTLVLKLYMLPVWENRRKILIYAIGIA
                     LFSYLMREVIGMPKLDFPLQYLLMVLFLRLGLGIKTYLAAFSAGSGLTAYINLQLFVYI
                     FANFFGVAQPDIINNTSGSSIYVIQLASIFTAYFISFVMGKYNFGFSFIIQPPHDFLKG
                     ENYLSPLNKMFIIGSLISFVTILVTLYMLYNSNTIGLLSISLLTFGISYFFSEKGDYED
                     ARNAIEAHRIRNKES"
     misc_feature    11355..11372
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            11476..11703
                     /locus_tag="PPM_RS13380"
                     /old_locus_tag="PPM_2569"
     CDS             11476..11703
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371426.1"
                     /locus_tag="PPM_RS13380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2569"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_013371426.1"
                     /transl_table=11
                     /translation="MALSDNFKKLRIKYHLTQQELAEIAGVTNKAISAWESGLSEPRMG
                     AIEKIARHLHIKKSNIIEDDGIEHISSDQV"
     gene            complement(11842..12597)
                     /locus_tag="PPM_RS13385"
                     /old_locus_tag="PPM_2570"
     CDS             complement(11842..12597)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013310483.1"
                     /locus_tag="PPM_RS13385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2570"
                     /product="DUF4247 domain-containing protein"
                     /protein_id="WP_013371427.1"
                     /transl_table=11
                     /translation="MSKRTWQYALKVIVALSLFVSVLSGCGAPNVKDTYPLESVSGSGN
                     STSYVYRAAGKTVPEVAEELKEQRTPEQMSPQSNERMFLVYSDEWYHLQQDPAKKEDTL
                     IEIDSKKYVEQNYSSSFLKGYLTATVLDALFDSLRGSGSYRGYSSRDVYRPSQGQYRAP
                     TAQEKKTIPPITVERKGSVTRRGKNSDSSVGSSGSLFDRGSSSSPSRGSISRDRGSSGG
                     SSIFDSPRKSYSKPKTRSGSGKISRRSRR"
     gene            complement(12611..13117)
                     /locus_tag="PPM_RS13390"
                     /old_locus_tag="PPM_2571"
     CDS             complement(12611..13117)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010348250.1"
                     /locus_tag="PPM_RS13390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2571"
                     /product="DUF4178 domain-containing protein"
                     /protein_id="WP_043885983.1"
                     /transl_table=11
                     /translation="MSVWKRISNLFAKPEPPKAEKSMLHLNPGDICEVSLVTYEVVGRV
                     HNRARNAVVLTLQDGNQVSYLHIEERETLQFGLYQAIDGRLDNPEEVPTILELDDITYH
                     LEEQYFGHVTVMGRAPFRQGGEQHVWQYQSDDYHLLRVEWQDGRFMLYEGEEVITGDVK
                     VIRAS"
     misc_feature    13094..13108
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 24.68"
                     /tool="antismash"
     gene            complement(13142..13549)
                     /locus_tag="PPM_RS13395"
                     /old_locus_tag="PPM_2572"
     CDS             complement(13142..13549)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820726.1"
                     /locus_tag="PPM_RS13395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2572"
                     /product="DUF350 domain-containing protein"
                     /protein_id="WP_013371429.1"
                     /transl_table=11
                     /translation="MHFLETMKAMLVWTGAGAILLFVLMYVDSLFTKYKDFAEVKAGNM
                     AVTVRMIMKLIAQGYILSGSIATANNLLEALVYSVIAFIILLVLEVIVRLLLRYWAQFD
                     LDKGTQEGKIGFGLFSGALHLVGALIITACF"
     gene            complement(13679..14347)
                     /locus_tag="PPM_RS13400"
                     /old_locus_tag="PPM_2573"
     CDS             complement(13679..14347)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007432515.1"
                     /locus_tag="PPM_RS13400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2573"
                     /product="PspA/IM30 family protein"
                     /protein_id="WP_013371430.1"
                     /transl_table=11
                     /translation="MSIFKRLRDLTMSNINAIIDKAEDPVKMTDQYIRDMQEDLEDAEK
                     AVAAQIAIEKRFKQQYEEQAALVKKREEQAHTAAKAQNVDLARRALEEKKSAEQKMNEF
                     QAGYEQNKAAADNLRGKLDEMRRQLTEMKNKRETLVARYNAAKAQTEINKAMNGFSSDT
                     ATAGLKRMEEKMLQAEARAEASNEMASKEKSLDEEFKELDKKSAVDDELAALLKQYENK
                     "
     gene            complement(14434..15456)
                     /locus_tag="PPM_RS13405"
                     /old_locus_tag="PPM_2574"
     CDS             complement(14434..15456)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371431.1"
                     /locus_tag="PPM_RS13405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2574"
                     /product="NADH:flavin oxidoreductase/NADH oxidase"
                     /protein_id="WP_013371431.1"
                     /transl_table=11
                     /translation="MTDLFTPYQLKGLSLKNRIVMPPMCQYSVEAKDGKPTDWHYVHYV
                     SRAVGGTGLIIVEMTAVHPDGRITDRDLGIWSDEHNPAYRKIVEEVHKYGAKIAIQLGH
                     AGRKAEDAETPVGPSSIPFSERFKDPHTLTRAEVKELVQAYKEGARRAVEAGFDTVEIH
                     GAHGYLIHQFHSPLTNTREDEYGQDLSLFGVEVIRAVKEVLPADMPVLMRISAKEYVQD
                     GYDVEYIAAIGERYRDAGVDIFHISSGGEGPIGSSGGPSARAGYQVDLAHTIREKLNVP
                     VIAVGLLDDYEDARRVVQQNEADLVAIGRAMLRDPYWALHASRALKVQADIPEPYLRGF
                     "
     gene            15760..16566
                     /locus_tag="PPM_RS13410"
                     /old_locus_tag="PPM_2575"
     CDS             15760..16566
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820724.1"
                     /locus_tag="PPM_RS13410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2575"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_013371433.1"
                     /transl_table=11
                     /translation="MRYRGVLPCLALLLAFSSFPVHADTPPNIGTPHPKEAAAATSVYQ
                     SKDRATPTLAMLRKKHADIFKMCGPHTRQIALTFDDVPDSRYTPQVLDVLHANGIKATF
                     FIVGHRAEKHPGIIRRIIREGHAIGNHSYTHPDFRKATPERFRHQITKTERILEASIGF
                     RPRLIRPPYGEITEPQIQWARRHGYMIVNWNVDSLDWKGLSKTQIQRNVIPATRPGSII
                     LMHAGGGQSSNLQGTVQALPGLIHSLKAKGYKFVTVPRLLHTSERK"
     gene            complement(16764..17432)
                     /locus_tag="PPM_RS13415"
                     /old_locus_tag="PPM_2576"
     CDS             complement(16764..17432)
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0009254 - peptidoglycan turnover [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687404.1"
                     /locus_tag="PPM_RS13415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2576"
                     /product="3D domain-containing protein"
                     /protein_id="WP_013371434.1"
                     /transl_table=11
                     /translation="MKHLKHIGQTMKFAVLAAAIAGLAQTAGVADAASLHTAKEGDTFF
                     LLAQRYGVSVDELTKANPDIASNNIYAGLQIKVPDEKSVKAASDSKPQLLTEKAPANEK
                     PTIEAWGKTFNYSKVVDVKATAYSAAADENGKWGAVDYYGNPLKLGTIAVDPKVIPMGT
                     KVLVTGYSHPGLPDHSFVAVARDQGSAITGKRIDIFIPGNKSFVNDFGFQNVKLYVIDK
                     "
     regulatory      complement(17439..17606)
                     /bound_moiety="cyclic di-AMP"
                     /db_xref="RFAM:RF00379"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00379"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cyclic di-AMP (ydaO/yuaA leader) riboswitch senses
                     the signaling molecule cyclic di-AMP; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(17850..18572)
                     /locus_tag="PPM_RS13420"
                     /old_locus_tag="PPM_2577"
     CDS             complement(17850..18572)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371435.1"
                     /locus_tag="PPM_RS13420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2577"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_013371435.1"
                     /transl_table=11
                     /translation="MITVKQLRKSFGKNEILKGIDIDIAKGEVVVIIGPSGSGKSTFLR
                     CMNLLEQPTEGEILFEGEPITARGHNINATREKMGMVFQHFNLFPHKTILQNLTLAPTQ
                     VKKQSGKEAEKIALELLRTVGLEDKKNTYPNQLSGGQKQRIAIARALAMQPHVMLFDEP
                     TSALDPEMVGEVLDVMKKLAEGGMTMVIVTHEMGFAREVGDRIIFMDNGQIIEQGTPEQ
                     VFGTPSHDRTRDFLAKVL"
     gene            complement(18559..20022)
                     /locus_tag="PPM_RS13425"
                     /old_locus_tag="PPM_2578"
     CDS             complement(18559..20022)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371436.1"
                     /locus_tag="PPM_RS13425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_2578"
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="WP_013371436.1"
                     /transl_table=11
                     /translation="MKKAYRFTALVLSAVILLLAGLPMLTAYGSEEKPQKKLVVGMSAD
                     FPPYEFHKVINGQDTIVGFDVEIAKEIAKDLNAEMVPEDMSFDSLLPALQSGRVDLVLS
                     GMTPTDERRKSIDFSDVYYRSKQVIMVRPEDKDKYSTMAALKGEKLGAQKGSIQEEIAQ
                     KVPNASVTSLDKISDLVLQLRTNRINAVVIEDTVAKGYTLDGTVTLAKAVPEDEGAETA
                     VGIRKGNAELLASVNKTLARLKADGSIEKFSTEASALSADRQVSSNSIVDIFLKYRSFY
                     ATGIGYTLLLSALGVLFGFIIGLIISLLRMSGIRIIEWLGTAYVEILRGTPMLVQLMII
                     HYGVALTLGVNFTPLQSGIITLSLNSSAYLAEIFRAGIQAVDRGQMEAARSLGMGRGKA
                     MRHVILPQAFKSILPAIGNEFITIIKESSIISTIGMVDIMYQAQVIKNITYEGLSPFVI
                     AAAIYFVMTFSLSKLLGLWERKLRASDHR"
     misc_feature    complement(20083..20096)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: strong, score: 19.49"
                     /tool="antismash"
     misc_feature    20333..20349
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.91"
                     /tool="antismash"
ORIGIN
        1 aacgggtgag cttcctgtat tagttatttt aaacttggag ctgatcgtat tacttgttgc
       61 agatatattc ccattgaaag attgcacctt cagagcgccc tcgcctgttc ccggctcact
      121 tggcgtatcc ccttttaccg taatcgtgaa caacgcatca ttgcctgtac taaaatggaa
      181 gttaagcgtt gtctctcctt tgggaagttt agataaatac ttgttggtaa gaatgactgt
      241 ttctccacta accgtataat cttcaccttt gctcagtgtc acgcttcctt gcttgatcgc
      301 atctagtgta ttaccgttaa gtgtaagctt tacagtaata tcgctattgc cgttagccac
      361 tccataggtt gcagctgtcg gtgtaatact tgcttgcccg gtcgaaggct gatccccccc
      421 tacacgatct gccaccagaa tgccgcgacc attcgttccc agataagcac gtccgtaaac
      481 ccgaggatcc ccaataatgg tggtcacacg agcatattga tgcttgtcat cattaatgcg
      541 tacccagttt gcgccagtat catccgagcg atagaatcca cgtgtaccgt caattttacc
      601 aacgataaac actgctgcat tggtgcgatt gggtgctgct ttgccaaagc ctacaaaatc
      661 cgcctcctgt acatgatcaa gcttggtgaa tgtaacacct gaatccttgg aatgccataa
      721 gccgtatggc cctccgtcct cggagcctcc agcaaaccac acatcccctt ccgctcctcg
      781 tacagcacca atatctgcat tccctacact tggcaaacca gtaactgtgg atgctgtgaa
      841 ggatgcgcct ccatcaacac ttacatatat ttttccagca gcaaacgcgt agtatttgtt
      901 agaatttact cggtcagagg cgatctttgc attggttgga attcccgtgc ttgctgtcca
      961 tgagtttcct ccggttttgg aataaaatac acctttgtcc gatgtactcc acagcaatcc
     1021 attaccattt gccgctacag cgatgctacc tcctcctgct gtaccagaag gctcgctatt
     1081 tgctttgtac cagttcgctc cgccatcatt ggaaaatcca atggatttgg catttggatc
     1141 ttttttatag tctgctttac ccacccgggc cataaaagaa gggttcagct cggcataatc
     1201 aatgctttcg ctgcttgtaa aggttggatt atccagcatt ttagcgggag ccttgaacag
     1261 atcatcatgt ctgaatccgg aaacatcacc cactgcactc actagaggag ctccagtagg
     1321 agggctcacc agatccaaaa tcgccgtttc ctctatccct ttagcggcta ccgagatgtc
     1381 cagcttatct cccttgtccc aattggtcag atttttagag ccatatatcg tagctcctgt
     1441 gccatacagc atatgatctg agttaaatgg atctatctca agatctccaa tcatccaccc
     1501 tagcttgggc gatacttctg gcggagcagg gttggcattg aaagtcagcc aaggcgcacc
     1561 ggatatatcc agattgtatt tgagcttacg agacgggtaa ccgtcgaatt cccaaatagg
     1621 gctccaggtt gctccactat cagtactgcg gtaaatcgtt tcatccggcc accaggcatt
     1681 caatgttgca accataaggg taccaggctt ctgggcatcc accgtcagtc caccataccc
     1741 aaaatgattg tctgcgctgc tgctggcaac ggggctaatg ttagtccact gtccgctggc
     1801 tgtattcaat ttccatagtt caccctttgt tccgtcatat ggcccagctc catcgctgta
     1861 agaaatatac aggtttccat ctggtgataa aacaccgtga tgtggcaaat aacctgtagg
     1921 ctgtcctgct acagcagacc aggttgtccc gccatctgta ctgcggtaga cactttgctt
     1981 tttgtctgcg acacccacat agatggtctg tgttgctttg ctggaagagc ccgttttttt
     2041 gtcaaaggtg atccaggcta aaccgacaat atcactggtg tattcatttg aagggtcctg
     2101 tacatacgtc cccggattcg ggaaaccgct caccttactc caggttgccc cgaagtcgga
     2161 gcttttccac agtccattac cacttcgagc tccgaagaat aatatattgt tcttattcgg
     2221 atcaattgtc agacgttcac ccatcgagcg tcccggcata ttgcctccta ccttaaaggg
     2281 aagcttcgta gtctgccatg tattaccttt gtcagtggag cgcataattt gcccgttatg
     2341 tttatcccag gaattagtat acgtacctgt agctatatat acacgattcg gatccacagg
     2401 atcggtggct agtgcgtcga caccattttt gttccaatct tcccagccca cagaatccgt
     2461 cagcggaatc cagctttcac tcgcaggatt ccagcggtaa gctcctccaa tatctgtacg
     2521 ggcatagatc agatcttttt ccgtttcatt aaaaataata ccaggtacaa aaccacctcc
     2581 accgcctgta acgacacttt tccaagtata atcgtcactt ggagcagcat gggtgggtgc
     2641 tatcatacct gtccaggaag cacccgctac tataagcgcc aaacatacaa ttctcaacct
     2701 gctttttgcc ttagtcaatg aattcaacct ccttctccgt aatcatttaa aaatgcaagt
     2761 catttcgagc taaaagtaag cagtcaattg cggattcgtt cctatcgtta ttattccatt
     2821 catcaatcaa acaagcgttc tctcaagctc acctccagta atccaataga tttgcaacct
     2881 cttctttgtt agcgcttaca ttagtgtctg ctcaaaagat tcgtcatctt tttctctttt
     2941 ccttgtgtga aaaatcaaga taatgtaata gtatcttttg cttgataact tgtaataaaa
     3001 gagttggctt ccacttacag ttgatacctc ttataaatta ctaatatgaa tttttcatat
     3061 aatgaattat tttctttaaa tttcattcga acgaggtacc aaaatacttt gatttacagc
     3121 aaaaaaccgc gctatgcgcg gttcgggctt ccgtaatgct atggctattc attaataggt
     3181 tgaaattact gcaaatattc aagcgccagc gctaaaaaaa tatgtcctga gatgagtaac
     3241 gcacgctcat caaaatcaaa gcgaggatgg tggtgagcaa aatgggttcg ttcatcctca
     3301 ttacgagcgc ccacaataat aaaagctcca ggtcgttgtt ctagataata ggcaaaatcc
     3361 tctgctccca tggccggttt taagtccata aaagcatctg ctccatacag cctactgact
     3421 agctcacgta cccgttctgt ttcggcctcg gcattcacca gagcaggata accattcaaa
     3481 taatcaattt cgtatcccgc atgataagca tccgttagac cttttacgat actacgaatt
     3541 tcgttttcga cttccttgcg tatatcctta ttaaacgtac gtacggtccc ttcaattttg
     3601 gctttatctg caattacatt aaaggcagtt cctgcttgaa ataccccaat cgttaacact
     3661 gctgattccg tagggtccac tctgcgactc acgacctgtt gtagtccgtt cacaatttga
     3721 ctgccgatga caatggaatc cactgtctga tgcggtctgg cgccatgtcc gcccttgccg
     3781 ttgatttcaa ttgaaaaggc atcggcagca gccattgccg gcccactctt taagccgatt
     3841 ttgcccagtg gaatttccga ggaaaggtga ataccatata ctgcttccac cccatccaga
     3901 caaccatcct caatcatgaa tttggctccg ccaggcggtt tttcttcggc atgttgaaaa
     3961 ataaacacaa gctttccctt cagtgtctca cggtgatggc ttaacactcg tgccactcct
     4021 agcaacgcag ctgtatgacc atcatgtcca caagcatgca taacaccggg aacggtcgat
     4081 ttataaggcg catccttttc atcctgaata ggaagtgcat caaaatcagc acgaaatgca
     4141 atcgttctac ctggctgccc gccttctaaa aaaccgagca caccgtttcc accgacattc
     4201 gttcttactt caataccaaa agagcgtaat tggtctgcga taaatgcaga tgtattcgtt
     4261 tcctcaaaag aaagctctgg atgctgatgc aaatatcttc tccacgcaat cagttcttgt
     4321 tcaccatctt ttagttcctg aacccatttc tccagcatat taccctcttt tcctattgaa
     4381 tttatatact tctatcctta tcttagcata aatgattcca ataagttata tatgaattac
     4441 caaataactg tatacctgcg tttttaccaa tgtcaatgca agttctaatt ggaacgatcc
     4501 atgaacagaa ggcttgaaat gacaacaaaa aagccgacaa aatattctcc tcggcttttt
     4561 tctggtggtt ttctattatg aatttttcat gtattgaaaa actgacttat attccctcgt
     4621 actggatgtg tttgctccct atactcacca ttcgtatagc ttccaatgac cttgcgccaa
     4681 aaggattggg ctggtctatt cgtgctcatc tgagtcacct tccatcgccc attaaaacgt
     4741 ccaaacagct catgagccgc ccaagtgccc acgccattgt gtcgataagg acgaagtaca
     4801 aagaactcag ccatgtaata gtcagcttct cgattgctag acattcggtc aacgagtgca
     4861 aagcccacag gaatatcctg tctccagatc aaaaaaggca gcttttgttc gtcgctcgtc
     4921 cagtattgat acaagtctgg ataagccggg aatgtcccct tctcagtgac atcaattcgc
     4981 agataggctg taaaatcgta taagtaaaat tgcatgagct ggacaataat gtccttctgc
     5041 gactctggta cactctttat ggacagcttc aattctgatt tgatattata tcccatactt
     5101 tcacctctct tggcggtcag cttgttcttt actttgatta ctcccatcca gtgctgttca
     5161 aaatatgcta aaatacatgt attatgaccg gacgaggtga accctatgaa catacaaaag
     5221 atcatcgacc ggcgcaaact ggatgaaaag ttgccggatt tgccatggta cgtacagcaa
     5281 tttatggatt acaagcttcc cgacctatcc ccctctactt tgctggaata tgtgcgggat
     5341 tacgaagctt ttttttcatg gcttcgctcg gaaggcttgt ctgccggaga aacgaatgcc
     5401 caagttacac tggaagaatt agagacactc catatggata gcattacagg ttttcgtttg
     5461 ttcctgtcta ccaaacgcga aggctccaat tcccgtatca ccatttcacg taaactatcg
     5521 tccttgcgtt cactctttca ttatttgagc caaatcgctg aggatgaaaa tttttatccg
     5581 ttgctcaagc gcaatattat ggccaaagtc gaaattaagc gcgtacataa acccaaggat
     5641 acagccgcca agctcaaagg aaaaatactg gaagaggaag agctgcttga atttatcggc
     5701 tatatttatg aaggctacgg acaagatttg gctgataaca agcaagccct atactcctat
     5761 gaattaaaca aggagcggga tgcctgtatc gcaagtctta ttctgaactc ggggctacgt
     5821 gtatccgaaa tcgtcaactt gaatatggat gatctcgata taaacaataa attactgtat
     5881 gtgtaccgca aaggaaataa cgatgaaact tttaaaacgc cagtatattt ccgcgagcag
     5941 tccaaagatg atctcgcact ttatttgtcc ttaagacata cccgttatcg cgctccaaaa
     6001 aaagaaaaag ctctttttgt cgcacgtccc aacggcagta cggagggcaa acggatgact
     6061 aaaagagcga ttcaagctat gatcatcaaa tacgccaaac ggttcggcaa accctatttg
     6121 accgttcaca agctccgtca ttcctttgct actgactatt atttacaaaa tgatatctac
     6181 aaaaccaagg aacagctggg tcacgcttcg actgaaacaa cggaagtcta tgcccacctg
     6241 actgacaaaa cgatgtctca ggcgatcgaa cgacggatag agactcagac tgacccagcc
     6301 gattaatggc cctctcagcc ctgctctgtc tggaatcctg ctctgtgcct ctgaatttgt
     6361 tcgagtaacc agcggcctgc cggatcgctg gcatcggcag gatatatctg caccgtttgt
     6421 tcatctgagt agtaatcctg agcccaatcc atatggcact cccaaactac tactccctgt
     6481 acatttgtca gctcctgaac aagtcgggca tccgattgtt ctcgcaccat gaccagcttc
     6541 ggatattttt cctgcttgaa gccttccagc aacacacagt catacgcctg aaaatgccgg
     6601 atgagtccgg tcacaggccg actatgttcc tctaaaatcg ctgttcttcc tgccgaaaca
     6661 atcgctacgc cttcggcgcc tgcctgtcgg tgcttgtacg tatctgttcc ctcatgatcc
     6721 atctcaaatt catggccatc atgcttgatc actgctacac gtagtcctga ctgctgcaca
     6781 taacgaatta aacctccgag gaaggtggtt tttcctgtat ttttgaatcc gacgatttga
     6841 catacaaatg gatgttttgt tttcacgtca cctgtccgcc ttgaagcacc agtacatgca
     6901 cctcttcacc ttcgcgcaag ccttctgttg tgggagggac tacgatcaga caatcgctgt
     6961 ccttaatcgt gaccatggca ctggattcat ctactcgcgc aggaatcgca tatacttgtc
     7021 caccacgtat ctccagagaa ctgcgtacaa agcgggtata gttgtttacc ttcgtataat
     7081 ctgctcctag cttcgctgtc caggtttgca aatacggatg taccgaagat aacatcattt
     7141 gaatagttgg acgtacaaac agctcacagc ctacaaagca tgcgccggga ttgcctgaga
     7201 gcgcaaataa cagcttgccg tctatcactg cggctgtggt tacactacct ggacgcatcg
     7261 taaccttgtt gaacagcata ttcacatctt cctgtcgcac gaggtcaccc ataatatcaa
     7321 aatcacccac cgacactcca ccactcgtaa ccacgatatc ataggtagct attgcttctc
     7381 tgacagaagc ccgagcaagg ttcaaatcat catgaatggc ttgcagaatg aacggctctc
     7441 ctcctgcctc tctaatttga gaagccagca tatatgtatt actgtttcga attttccccg
     7501 gttgtaacgg ctcatccact gcgagcaatt ctgaccctgt ggaaaagacg gccacccttg
     7561 gcttcctgta aacgggcacc cgatgtacac caaaagtagc cagtaccgag atgtgccctg
     7621 ctcccacaca agttccctta ctgagcaaaa gctgaccttc cttaatctca tgaccaattt
     7681 gtgtcacatt tttgccaact tccatacgct tcttcaagcc aacatatgtc tgtccatttt
     7741 cctcacgcag ctgtgtcgcc tccagcataa ccaccgtgtc cgctccttca ggtaattgtg
     7801 ctcctgtcat gatgcgggct gccattcccg tctccacccg cttgtccgat acggtgccac
     7861 aaggaatttc atcaatcaca tgtagccaga tttcctgacc agtcgaacag acttcagtgt
     7921 ccgaggcaag gatcgcatag ccgtccatac cagagcgacg aaagcgggga tacggatgtg
     7981 gcgcagtcaa atccatcgcc agatagcgac catgtgcttg ctcaagccct acgtcctccc
     8041 tttcgctctg ttgaacataa ctagctatcc tgctttgtgc ctcttccacc ttaactgctt
     8101 tacgttggaa tttttctgta tttaatggcg tctgattcat gttctcactc cgttcttcta
     8161 aaataccctc tttctgttat aacgctaaaa ccgttatctg gcaaatctga acggtattta
     8221 ttggattgct gcaagtctct atccgccaaa aaacagcctg aatatcatat cgcggctgtt
     8281 tttggtagac tttagtcttt ggtttttggt tttgcatgtc atcacgtcag ttttctacgt
     8341 atattaggtt atattatttt taccgaaata gattgaatct attgaaacct catacaacga
     8401 ggacatttgc tgcgctcgag ctattgttaa atcagatgaa tcttcctcta tatgttttaa
     8461 ttcattcatt gacataccaa gtatattgca agctattaac tcactatatc ctgaagcgag
     8521 tcgtgccatc tttattgtat aaaagctagt gcaagttaca ttttcatttt tatctgcaac
     8581 catccaatca actccacaat ataattgata aaaaagtaat ttacctgtat actctgaacg
     8641 aaacactttt cccctgttag gagcaagtaa ggtgcaaaaa cttactcggg ggaaatgcct
     8701 tttgaaagag gagctcaaat ctcatggacg cactcaatca tggctcgccc gacgaactgg
     8761 atattcgcgg caacaaatat ccaactggat cgcgggacgt gacaaaatgt cattcgaggc
     8821 ggcagtcctc atttctagga tattggagtg taaagctgag gacttatatg agtgggaact
     8881 tgcctgacaa acaggcattt ccttcggggc atttgtacat gccggcattt acaatatata
     8941 tcccgctttc accctccttt tcttatatgt agattgtttt caccttaatt taaaagattg
     9001 ttattttttt cataatcaat tttatcacat ggagaatgat taaaaacggg aaatatgtcg
     9061 aattaaatcg aaaccgtccg gcttatccta gtctaactga ttattgactt attcatttaa
     9121 atctggtaac aaaaatgacc cctgaatttt catgggtcat ttccacagtt ttttaagcgc
     9181 tttaagttta ttatgagaca tcgagcaagt gaagtcagat ccttcgaatc gtaccagccc
     9241 tccaaatgcg ttagactcaa tttcacaaac caagtcgaga tttatcaggg tatctttata
     9301 agctggatat agatacggaa aagcttccct gcaagcctgt gcggttagcc cgattgtata
     9361 agagcgatct ccagagtgga aacgcgggac atagtaattt tttttaggtt cccacatatc
     9421 cacactaagc atattcccta ccttaaaaaa accgctcact gttgccttac ccactacctt
     9481 gatttccgat ccgaaaatat aacgaatttc tctatcggca ttcattgcat ccgcatatat
     9541 ttgtttccat cgagataaat tggctgaatt tatactttct ttgatgtctt gatttttaaa
     9601 aacaacctgc ccccctccat aatctcccgt aacgatcttg tccacttgtg tgatgttaac
     9661 caaattagat ccgtccaaat tgcaaaaagt gggtaagcct acggaacatt catggagggt
     9721 ggtgggaact gtaaatcttc catgagaagt atgaaaaagc gggatgtgat aattgctttt
     9781 aggcttccac aattcaatcg caactaggtg attttcgcaa aagaaagagc aatctccaag
     9841 tgaattgtca tcaagcaatg gagtggctag gattcgcttt ccctcttcca ttaaattcag
     9901 ttcttttctg ttttcttcag ctcagctggt accggtttag cgccaaatat tgttttttct
     9961 tttttggtag actcgttagc gtatttccca aggcttatac ttaaaactct cgccaatttc
    10021 ttatccattt tcgctcacct cctttccata aaggaagaat actgaatgct tgtataacta
    10081 tagataaaca tattatgtga gattgtacaa aaaaatttaa tatgcaaacc aaaatacata
    10141 tcgttttata atacttgtga tatttggtct tattaatata gataaaatga ttgggagcat
    10201 atactacaaa cactaataat gaacaagcgt taattatcaa aattgttgat aaacctaaag
    10261 aaacaaaagg tatagttaca catatggccg ttgtaaaaca gacacaaagg gtaaggttgc
    10321 tgaagtgtac cccacctgaa aatctcctta caaacatgat cgtagccaga gctagtaatg
    10381 ccccccaaaa atgtcctgtt atccaggcta taactgcaac cattagtact gccgaaattt
    10441 cggttatttt tataccaatc gcatactcca tcacttctac acttgtaggt ccatcaggat
    10501 cagctttctt tatttctgat gcgatgtgcc tcgatagcgt ttctagcatc ctcgtaatct
    10561 cctttctctg aaaagaagta cgaaattcca aaagttagca atgagatgga aagtagtcct
    10621 atcgtattgg agttatagag catatacaaa gtaacaagaa tagtgacaaa tgatattagg
    10681 gagcctatga tgaacatttt attaaggggt gataggtaat tttcaccttt caaaaaatca
    10741 tgtgggggct gaatgataaa tgagaaacca aagttgtatt tccccatgac aaaagaaata
    10801 aagtacgcag taaaaataga agctaactgt ataacgtaaa tggaagaacc agaagtatta
    10861 ttaataatat caggttgtgc tactccgaaa aaatttgcaa atatatatac aaatagctgt
    10921 aggttaatgt aagctgttag accagaacca gcagaaaaag ctgcaagata tgttttgatc
    10981 cctaaaccaa gtcttaaaaa gagaaccatt aacaaatact gaagcggaaa atctaattta
    11041 ggcatgccta taacctctct catgagatag gaaaacaaag ctatgccaat tgcatagata
    11101 agtatttttc ttcgattttc ccacacagga agcatataaa gcttcaagac caaagtaact
    11161 gccgctaaag catcgaaaaa accaagtgaa atatataaaa aagcagataa cacagttaca
    11221 tcatcctcct atttcgcctg atgtaattgt atattttact aatagaagtg gcaatgaaat
    11281 aatctagtaa actggtaatt tttgtgcaat ttgaggtaaa tatttttcca tttgactttt
    11341 ttcttcaaat tctatatcca tttgtgctaa taaaaaagcc cccaagtggg cgacgttgtt
    11401 tttgccaatg tattatgttg gttttttttc gatatcaagg ttataatcta cttaatttgg
    11461 ggtggaggga ttatagtggc tttaagtgac aattttaaaa aattacgtat aaaatatcat
    11521 ttgactcaac aagagcttgc tgagatcgct ggggttacca ataaagcaat ttcagcttgg
    11581 gagagcggac tttctgaacc acgaatgggt gctatagaaa agatagctcg tcatctccat
    11641 atcaaaaaaa gcaatatcat tgaagacgat ggcattgagc acataagttc tgatcaagtg
    11701 taggtcaaag tagacggtaa taaaatcgaa gtgagagcat ccgttcaatt cactgtaggt
    11761 tatatcaaac aacaaaaaaa ggaactgtgc atcagctcca cagttccgca aacaacttta
    11821 gaagaatata aagtattacc attatcgtcg actacgccgg ctaattttac ctgagccgct
    11881 gcgtgtttta ggcttactat acgatttgcg cggcgaatca aatatgctgg aaccgccgct
    11941 gctgcctcgg tcacgtgaaa tcgagcctct gctcggtgaa ctgctggagc ctctatcgaa
    12001 taaactcccg cttgatccaa cgctggaatc cgaatttttc cctctacggg taactgagcc
    12061 ttttcgctcc accgttatcg gcgggatcgt ttttttctcc tgtgctgttg gagcacgata
    12121 ttgcccttgt gaaggtcggt atacatctct gctcgaataa cctcgatagg agccagaccc
    12181 ccgcaacgaa tcgaacagag catccagcac agttgcagtt aagtatcctt ttagaaagct
    12241 ggaactgtaa ttttgctcga catacttttt actgtcaatt tcaatgagtg tgtcttcctt
    12301 cttagctgga tcctgctgca aatggtacca ctcatcacta tataccagaa acattcgctc
    12361 attgctctga ggtgacattt gttccggtgt acgctgttct ttcaattcct ccgctacttc
    12421 gggaaccgtt ttgcctgctg cgcgatacac gtacgaggtc gagtttccgc taccactaac
    12481 ggattccagc ggatacgtat ctttcacatt tggcgcgccg cagccgctta acacggatac
    12541 gaacaagctc agcgccacaa tgacctttaa tgcatattgc caggtgcgtt tgctcatgtg
    12601 taaccctctc ctagcttgcc cgaataacct tgacgtctcc ggtaatcact tcttctcctt
    12661 cataaagcat aaagcgaccg tcctgccatt ctacccgcaa tagatggtaa tcatcagact
    12721 ggtactgcca aacatgttgc tctccaccct gccggaaagg agcacggccc ataacggtaa
    12781 catgcccaaa atactgttct tccaaatgat acgttatatc atccagttct aaaatggtcg
    12841 gtacttcctc cgggttgtct agtctgccat cgatggcctg ataaagcccg aattgcagtg
    12901 tttcccgttc ctcaatatga agataactca cttgattacc atcctgaagc gtcaaaacaa
    12961 cggcattccg agcacgatta tgtacacgac ctaccacttc ataggtgaca agcgacacct
    13021 cacaaatatc ccctggattt aagtgaagca tgcttttttc cgctttcggc ggttcaggtt
    13081 tggcaaatag atttgaaatt cgtttccata cactcatggt catattccct ccttactttg
    13141 cctagaagca tgctgtaatg attaaggcac caaccaaatg cagcgctccc gaaaacagac
    13201 cgaaaccaat tttaccttcc tgggtacctt tatccagatc aaactgtgcc caataccgca
    13261 acagcaggcg cacaatcact tctaaaacaa gcaggataat aaaggcaatc acagaataca
    13321 caagcgcttc gagcaaatta ttagcggtag caattgaacc tgataaaata tatccttgtg
    13381 caatcagctt cataatcatc cgtaccgtta cggccatatt tccggctttt acttcggcaa
    13441 aatccttata ctttgtaaat aaagaatcga catacattaa tacgaacagc aaaatagcac
    13501 ccgcgcccgt ccataccagc atcgctttca tcgtttctaa aaaatgcatt tgctaccatc
    13561 ctccacatct tcttgaatac atatattaat ttacgccccc aggcagggaa aagcgaagga
    13621 gaaaacgttt ctccttcgct tactgagcca tcacactagc ggcaatactt aaaagttctt
    13681 atttgttttc gtattgtttc agcaaagcag caagttcatc gtccacagca cttttcttat
    13741 ccagctcttt gaactcttca tccagcgatt tttccttgga agccatttcg ttgctcgctt
    13801 cagcacgtgc ttctgcttgc agcatttttt cctccatacg cttcaatcca gcagttgccg
    13861 tatccgagct aaaaccgttc atagctttgt taatttcagt ttgcgcttta gctgcgttat
    13921 aacgggcaac cagtgtctcg cgcttgtttt tcatttcagt cagctgtcta cgcatttcat
    13981 ccagcttacc acgcaggttg tcagctgcag ctttgttttg ctcataacca gcttggaact
    14041 cgttcatttt ttgttcggca gatttctttt cttccagcgc acgacgagca agatccacat
    14101 tttgtgcttt tgcagccgta tgagcctgtt cttcgcgttt tttcaccaaa gctgcctgtt
    14161 cttcgtattg ctgtttgaat ctcttttcaa tagcaatttg agcggctacc gctttctctg
    14221 cgtcttccag atcctcttgc atatcacgaa tgtattgatc cgtcatttta actggatctt
    14281 ctgccttgtc gataatggcg ttaatgttag acatcgtaag atctcttaat cgtttgaaaa
    14341 tagacatgtg aagttcctcc tagaattgaa tgcttaaatt ttaagctctg tacacatgtt
    14401 tacgcaagct ttgcaaagag gtttcaaaaa tatctaaaaa ccgcgtagat aaggctctgg
    14461 gatatctgcc tgtactttta gcgcccgtga agcatgcagc gcccaatagg gatcacgcag
    14521 catggcacgc cctatggcta ccagatcagc ttcattttgc tgaacgactc ggcgggcatc
    14581 ctcataatca tccaataagc cgacagcaat gacaggcaca ttcaattttt cacggatggt
    14641 atgagccaaa tcgacctgat aaccagcacg cgcagacggg cctccgctgg agcctatcgg
    14701 accctcacca ccagaagaaa tatggaaaat gtctacacct gcatcacgat atcgttcccc
    14761 tatggctgct atgtattcaa catcatatcc gtcttggaca tattctttgg cagatatccg
    14821 cattagcaca ggcatatcag caggaagtac ctctttaaca gcacggatca cctcaacacc
    14881 aaacagtgac aaatcctgcc catattcatc ttctctggta ttggttaaag gggaatgaaa
    14941 ttgatggatc agatagccgt gagcaccatg aatctctacc gtgtcaaaac cagcttctac
    15001 cgcccggcga gccccctctt tgtaggcctg aaccagttcc ttgacttctg ctctcgtcaa
    15061 agtgtgggga tctttaaagc gttcactaaa ggggatcgag gacgggccta caggtgtctc
    15121 agcatcctcg gccttgcgtc cggcatggcc taattgaatg gcaattttgg caccatactt
    15181 gtggacttcc tctacaattt tgcgatatgc aggattatgt tcgtcactcc aaatgcccaa
    15241 atcacgatcc gtaatgcgtc catccggatg aaccgctgtc atttccacaa ttatgagccc
    15301 agtccctcct accgcgcgac tcacataatg gacataatgc caatccgtcg gtttgccgtc
    15361 cttggcctcc acgctgtatt ggcacattgg gggcatgaca atccgatttt ttaatgaaag
    15421 cccctttaat tgataaggag taaacaagtc ggtcactttt atccatcctt ccctcaattc
    15481 caagtatgta tcattatgaa tagcatcccc attatacacc agctgtcacg gtataccgaa
    15541 tcctttgtaa ggctaaaact tgcgaaaatg cttcagtttt cggtcatgtt taagagaaaa
    15601 tgtacgttta cttcgtcatc ttcacggata cccgcttcat gatgtacttc tcttcagccg
    15661 tgtagggctt cactcaatca ccagcataat tttaatagga caggtacata atagctgaga
    15721 gcaccactag gtaccactgc acggaaaggg ggaatacaaa tgcggtacag gggagtgttg
    15781 ccatgtttag cactgttact agcattttca agttttcccg ttcacgcgga cacgcctcct
    15841 aacatcggaa cgccccatcc caaggaagct gctgccgcta cttcggtata tcaaagtaaa
    15901 gatcgagcta ctccaacatt agcgatgcta cgaaaaaagc atgcggacat ttttaaaatg
    15961 tgcggcccgc acacccgcca aattgcctta acctttgatg atgtgcccga ttcaaggtat
    16021 acgccgcagg ttttggacgt attacacgca aacggtatca aagctacctt ttttatcgtc
    16081 ggccaccgtg cggaaaagca tccggggatc atacgccgca tcatccgcga aggtcatgct
    16141 ataggaaacc attcctatac tcatccggat ttcaggaagg ccacaccaga acgttttcgc
    16201 caccagatta caaaaacaga acgcatttta gaagccagca taggttttcg acccagattg
    16261 atacgaccac cctatggtga aatcacggag cctcaaatcc agtgggcacg tcgtcatggg
    16321 tacatgatcg tcaattggaa tgtggactct ctagactgga agggattaag caaaacacaa
    16381 attcagcgca acgtgatccc ggctaccaga cctggctcca ttattttaat gcatgcaggt
    16441 ggaggtcaaa gttccaactt gcaaggcact gtccaagctt tgccgggtct aatccactct
    16501 ctaaaagcta agggctacaa atttgtcact gtcccccggc tacttcacac atcggaacga
    16561 aaataacagt atgtctaagc ttcaaatata ccaacaacgt aaaaaggctg ccttaacgag
    16621 cagaatgctt ctgcttgtaa gacagccttt tttagcgata aacgaccggg cctaataaaa
    16681 agtcgtccca gttatatgtt gtatgataga tcaagtttac ataacttata ttatgtttaa
    16741 tcaaatcata cataagcaca atgctattta tcaatgacgt acagtttcac attctggaag
    16801 ccgaagtcgt tcacgaatga tttattgcca gggataaaga tatcaatccg ctttccggta
    16861 atagcactgc cctgatcacg ggcaacggcc acaaaagaat gatctggcaa tccgggatgg
    16921 gaataacctg taactagcac ctttgttccc ataggaatga ctttcgggtc taccgcaatt
    16981 gtacctagct taagcggatt gccgtaataa tcgaccgcac cccatttgcc attttcatca
    17041 gctgcggcag aatatgctgt agctttaaca tcaactactt tactgtaatt gaatgttttg
    17101 ccccatgctt caattgttgg cttctcattc gctggtgctt tctctgtaag aagctgtggc
    17161 ttcgaatccg aagccgcctt tacacttttt tcgtctggca ctttaatttg cagacctgca
    17221 tatatgttgt tggacgcaat atccgggtta gccttcgtca actcatctac tgatacccca
    17281 taacgttgag caagcaaaaa gaaggtatcg ccttctttgg cagtatgaag cgaagcagca
    17341 tctgctactc cagctgtctg tgccagccct gcaatagctg cagcaagcac cgcaaatttc
    17401 atagtttgtc caatatgttt taaatgtttc aaagatatgt acctcctctg ttatgcctgc
    17461 gaagttagct gtcggattcg gactcaggag aagccctatg cttgtgcaat tcacccctag
    17521 gcatatccac aacatcttat gatgcattgg aatcattgcc gttgttacgt cccccgcact
    17581 tcccatggtt tgagcccagc acctgagtat ttattatcat tactgctgcc ccggtaagtt
    17641 ttggctcact gcataatatc acaattttgt aaccttatct gcatgaaaat gttggtaacc
    17701 ttgaatatca tactatactc attacaattt tgtcatcaag aatccgtttt ctgttacgaa
    17761 aatatggaga tatggtgaca aaaagagaaa agccctccgt gaaacatcat cacgagaggg
    17821 ctttgttaat atttcataaa agcattttct tacagcactt tagcaagaaa atcacgggta
    17881 cggtcatggc ttggagtacc gaatacttgc tcaggcgtac cttgttctat aatttgaccg
    17941 ttgtccataa agatgattcg atcccctacc tcacgggcaa agcccatttc atgcgtcacg
    18001 atcaccatcg tcatgccgcc ctcagcgagc ttcttcatca cgtccagaac ctctccaacc
    18061 atttcagggt caagagcaga agtaggctca tcgaacagca ttacgtgcgg ctgcatggcc
    18121 aaagcacgtg ctatcgcaat acgttgtttt tgaccgccag ataactggtt cgggtaggta
    18181 ttcttcttat cctcaagacc cacggtccgc aggagctcca gcgcaatttt ctccgcttct
    18241 ttccccgact gctttttcac ctgcgttggt gcaagcgtca gattctgcag tattgtttta
    18301 tgcggaaaca gattaaaatg ctggaaaacc atccccatct tctcccgagt cgcattaata
    18361 ttatgaccac gggccgtaat cggctcaccc tcaaacaaaa tttccccttc tgttggctgt
    18421 tccaacagat tcatacaacg caaaaacgta ctttttcctg aaccactcgg accgataatg
    18481 acgactactt cacctttggc gatatctata tcaatgcctt ttaaaatttc attcttaccg
    18541 aatgatttac gcagttgttt aacggtgatc actggctctc aacttccttt cccataaacc
    18601 caacagctta gataagctga atgtcattac aaaataaatg gcggctgcga ttacgaacgg
    18661 actcaagcct tcgtaggtaa tattcttaat gacctgggct tgatacataa tatccaccat
    18721 cccaatggtc gaaataattg atgattcttt aatgatcgta atgaactcat taccaatagc
    18781 aggcaatata gatttaaatg cttgcggtaa aatgacatga cgcattgctt tgcctcgtcc
    18841 catcccgagc gagcgggcag cttccatctg tccacggtct actgcctgaa taccagcacg
    18901 gaaaatttca gccaaatatg ccgaactatt cagagacaac gtaattatac cggactgaag
    18961 tggcgtaaaa ttaaccccca acgtcaaagc aactccgtaa tgaatgatca tgagctgcac
    19021 cagcataggt gtgccgcgca gtatctctac atatgcggta cctaaccact cgataatacg
    19081 aatcccactc atccgcagca aggatatgat cagaccaata atgaatccga acagtactcc
    19141 aagcgcagac agcaataggg tgtagccgat acccgtagcg tagaaactgc gatatttcaa
    19201 aaatatatct acaatgctat tcgaagaaac ttgtcggtct gcagacagtg cacttgcttc
    19261 tgtagaaaac ttctcaatcg aaccgtctgc tttcaggcga gccaacgttt tatttactga
    19321 agcaagcaat tccgcatttc ctttacgaat gcctacagca gtttctgctc cttcatcctc
    19381 aggtactgcc ttggcaagtg ttacggtacc gtctagtgtg tatcctttag caacggtatc
    19441 ctcgattaca accgcgttga tacggttggt ccgaagctgg agtaccagat cggatatttt
    19501 atccaatgag gtcacagaag cattaggcac tttttgcgca atttcttcct ggatactccc
    19561 cttctgcgca ccgagcttct ctccttttag agcagccatc gttgaatatt tgtctttatc
    19621 ctctggacgt accataatga cttgcttgga acgatagtat acatccgaaa aatcaatgct
    19681 ctttctgcgt tcatccgtcg gtgtcatacc ggacagtacc aagtctacgc gaccactttg
    19741 cagagcaggc agcaaagagt caaaactcat gtcctctggg accatctccg cattcagatc
    19801 cttggcgatt tccttggcaa tttcaacatc aaacccaaca atggtatcct gaccgttaat
    19861 aactttatga aactcatacg gcggaaagtc agcactcatg cccactacaa gttttttctg
    19921 tggcttttct tccgatccgt atgcagtgag catgggaaga ccagccaaca gtaagataac
    19981 cgccgacaaa accagggcgg taaaacgata tgcctttttc aatctttttt tctctcctta
    20041 aattctttat aataaataag attgtgtcat tataaatgaa tatgcatgat tatgcaatga
    20101 atgttatagt acaattttag tatatctatc gcagtaccta cattacagca tatataaagg
    20161 agtttttagc atgaatttca aacagaccat tcaacacacc attgaacagc atgcccagcg
    20221 gtttaaggac atttcgttat atattggcgc aaaccctgaa cttggaaacg aggaattctt
    20281 ggcctctgcc cgtttaaaag atgaacttgc ttttcacgga tttgaagttc aggcacccgt
    20341 attgggtata gaaacagcct ttattgctac ttacaaagca accaagcctg gaccaatcat
    20401 tgcttttctg gcagaatacg acgctctgaa agggctagga cacgcctgtg ggcaccattt
    20461 gatatgtatg atgagtacag gcgctgccgt aggtctcaaa tcgattatcg acgagactgg
    20521 tggagaagta cgtgtatacg gcacacctg
//
