LOCUS       NC_017542              27016 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Paenibacillus polymyxa M1, complete sequence.
ACCESSION   NC_017542
VERSION     NC_017542.1
KEYWORDS    RefSeq; complete genome; complete replicon.
SOURCE      Paenibacillus polymyxa M1
  ORGANISM  Paenibacillus polymyxa M1
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Niu,B., Rueckert,C., Blom,J., Wang,Q. and Borriss,R.
  TITLE     The genome of the plant growth-promoting rhizobacterium
            Paenibacillus polymyxa M-1 contains nine sites dedicated to
            nonribosomal synthesis of lipopeptides and polyketides
  JOURNAL   J Bacteriol 193 (20), 5862-5863 (2011)
   PUBMED   21952539
REFERENCE   2  (bases 1 to 5864546)
  AUTHORS   Blom,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2011) Cebitec, Bielefeld University,
            Universitaetsstr. 25, D-33615, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 01:49:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,687
            CDSs (total)                      :: 5,531
            Genes (coding)                    :: 5,427
            CDSs (with protein)               :: 5,427
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 45 of 104
            Pseudo Genes (incomplete)         :: 71 of 104
            Pseudo Genes (internal stop)      :: 16 of 104
            Pseudo Genes (multiple problems)  :: 23 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:14:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1684139
            Orig. end                         :: 1711155
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE577054.1.
            Accession number for plasmid pPPM1a in this genome project:
            HE577055.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27016
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="6"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27016
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27016
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17016]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17016
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    446..459
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.94"
                     /tool="antismash"
     gene            1151..2335
                     /locus_tag="PPM_RS07415"
                     /old_locus_tag="PPM_1413"
     CDS             1151..2335
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370157.1"
                     /locus_tag="PPM_RS07415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1413"
                     /product="hypothetical protein"
                     /protein_id="WP_013370157.1"
                     /transl_table=11
                     /translation="MMKKNLDSHGKKNGFPRLKHPYARFFRHKVTGLLMTGLIAGGLLG
                     GCGIKSAGETIPTSGMKPGQKLTVIDMEAARQQVSDELVVQSIDKLGDVYARSWLSDEE
                     LIVERQNQLWIHNVKTNKERVLTPGRKALQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELSSGKVTSAGQLDMTNEVSWGDKDHLITGTPDGKIHLIGLDGKAEELSFQDPNHSEL
                     IAHVEKVGNAIFYTGNDKQGYPVLNRFTLNHPQAVTIAEGAMSFAVSLDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSNDGSKLAFSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSTSARFLSMYQNISEGGKQLNQSYIVEFKKKQ"
     gene            complement(2403..3845)
                     /locus_tag="PPM_RS07420"
                     /old_locus_tag="PPM_1414"
     CDS             complement(2403..3845)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="PPM_RS07420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1414"
                     /product="SpoVR family protein"
                     /protein_id="WP_013370158.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLDGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATAERISSYEMEYGSKAVESFIDSVLAIQEHVDP
                     QLIKPRHLDKQRYMELKIKEQKEPKKHQRPIGPYDDLWSLDTVKQHDSAETEGIKVRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGDETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKIFEVREFDSDTSFIRNYMTKQLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TMIEGKLALFSYDGKKHHRKFV"
     gene            complement(3842..5008)
                     /gene="yhbH"
                     /locus_tag="PPM_RS07425"
                     /old_locus_tag="PPM_1415"
     CDS             complement(3842..5008)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="PPM_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1415"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_013370159.1"
                     /transl_table=11
                     /translation="MTEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPHLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGNPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSTYNIYPFHFSDGDNLSSDNERCVKLIEELMKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKTDQFMYYVIKEKGEVYQALRTFFRKREGGTVG"
     gene            5172..5891
                     /locus_tag="PPM_RS07430"
                     /old_locus_tag="PPM_1416"
     CDS             5172..5891
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /function="response regulators consisting of a CheY-like
                     receiver domain and a winged-helix DNA-binding domain"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="PPM_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1416"
                     /product="response regulator transcription factor"
                     /protein_id="WP_014599581.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTKVLKKEGFLHVKHAATGQEALQIVM
                     ESRIDVIVLDVMLPDNDGFEVCRQMRLYTEVPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRNVTTADMKPALQTLDFGYFCLELESGALYVQDQEVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYEAIWSETFLGDEKTVVIHISRLRKKIEPDPKHPQFLVN
                     VRGLGYKMISVKRGEQE"
     gene            6059..6958
                     /locus_tag="PPM_RS07435"
                     /old_locus_tag="PPM_1417"
     CDS             6059..6958
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="PPM_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1417"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_228392891.1"
                     /transl_table=11
                     /translation="MQSIVFIAVYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPER
                     KKNQSNNYKPPYQLYKEVFEQMNILSAQLRSNEEERMEIEKRKQQWVAGVSHDLKTPLS
                     YIEGYAAMLTAQEYDWSEEEKRSFSMAISEKVTEMKQLIQDLNASMQLKEGALPIQLKK
                     EDIVEFLRNTVIDIANHPSAEQYEFSFMSLEAVCVVPFDSKLLGRALKNFLMNAIIHNP
                     PGTHVSMEVNKESDKLHISIEDDGIGMNPTEFIQMTPSKEHGIPIAKSFIEAHNGTLHI
                     LPGSQEGTRIEITLPLNM"
     gene            7101..8024
                     /locus_tag="PPM_RS07440"
                     /old_locus_tag="PPM_1418"
     CDS             7101..8024
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="PPM_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1418"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013370163.1"
                     /transl_table=11
                     /translation="MSEYVIRTRQLTRRFGKREFVKQINLQVPGKQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGDIEIFGKKLKDHRMEILKDVGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRKIHKVLDLVRLSKDAYRPVKGYSLGMRQRLGIAMALIADPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPDAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTD
                     KSKPQLFIETQNPVQAAGALMQHGWIAGAESMEQKEVITPIVDREQSSEMIKVLVEHNH
                     PVYRVREKKKTLEEIFLELTGKERSL"
     gene            8021..8728
                     /locus_tag="PPM_RS07445"
                     /old_locus_tag="PPM_1419"
     CDS             8021..8728
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="PPM_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1419"
                     /product="ABC transporter permease"
                     /protein_id="WP_013370164.1"
                     /transl_table=11
                     /translation="MILQVIKAEGYKLKKICWWLPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFISFVMLLGCTLLASIMAGTEHDTQTWKQLMAMPVPRSYIYVSKIVWI
                     VILQLGTALITIAGMSLIWVLYTNEPIPWRVMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKLLPWSYPALSSPLIKEYVMWVVIALCAGIIFT
                     GLGTLQFTKHEFK"
     gene            8743..9477
                     /locus_tag="PPM_RS07450"
                     /old_locus_tag="PPM_1420"
     CDS             8743..9477
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="PPM_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1420"
                     /product="ABC transporter permease"
                     /protein_id="WP_013370165.1"
                     /transl_table=11
                     /translation="MGSILRVEAMKLQWVMVWILIILDAVINSLMGVLELNDLKQFYEP
                     SWLMLYTYAAHFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQRIYYAKYIL
                     LILILFLDQLTFIVGYFAGGYIAGAPGEIPWTLVLSTGWGGWFGILPLAALQLMLSVKI
                     RNFGASLGMAICCVVPNIVMTGFHSSIGAWFPFTIPYYIMLPQTASYAPRVEPYSLGLI
                     VLFTFLAYLYGGRKMFVNRDWL"
     gene            9639..9830
                     /locus_tag="PPM_RS07455"
     CDS             9639..9830
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="PPM_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_013370166.1"
                     /sec_met_domain="TIGR03731 (E-value: 9.9e-05, bitscore:
                     20.5, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKMKKKQKGDDVMKNQFDLDLQVTKSESASKELQADSGIICTPT
                     CLTSILNCYTSISHCGPC"
     CDS_motif       9639..9749
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MIKMKKKQKGDDVMKNQFDLDLQVTKSESASKELQAD"
                     /locus_tag="PPM_RS07455_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9750..9830
                     /prepeptide="core"
                     /locus_tag="PPM_RS07455_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="6.80"
                     /molecular_weight="2544.0"
                     /monoisotopic_mass="2542.2"
                     /core_sequence="SGIICTPTCLTSILNCYTSISHCGPC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIKMKKKQKGDDVMKNQFDLDLQVTKSESASKELQAD"
                     /leader_location="[9638:9749](+)"
                     /alternative_weights="2562.0"
                     /alternative_weights="2580.0"
                     /alternative_weights="2598.0"
     gene            complement(10001..11362)
                     /locus_tag="PPM_RS07460"
                     /old_locus_tag="PPM_1421"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="PPM_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1421"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_013370167.1"
                     /sec_met_domain="LANC_like (E-value: 2.5e-53, bitscore:
                     179.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTGQFVMEVCDQLQAKDFSTTIALRLSNPESVYKAVHAEQNISP
                     ETKYHPWGETSLSHGYPGNIFLLSQCRASDSTYDWNQAIYLNMKHIQASLAKSGLNDVS
                     LYSGWTGIASSVREASNHGEYYSHFLQQIHEWMIPLTEQWLQLNTAQLALHEGMPLQSF
                     DTISGATGIGRYIVMNSTDPSCTPLVEPILQFLTDLTYPIKIHNRYVPGWYSPQKFQFL
                     DRDKRNYPMGNFNCGMAHGIPGPLALLSVAYNSGIEVKGQYQAIETITEWLLKYKNEDT
                     YGYYWPHIVPFEAETGSLQFDLNRAREAWCYGTPGVACSLFLAGKALHDEVLQKMAVKA
                     CIGAISYEVAKREMDSSALCHGLAGLLTISWRMWCHSKEPAFIPLIQQLTSQLIDRFQA
                     DSPLGYLDPEPRADSSLAWLTKAGLLEGVAGIASALLSVSQNKEMPWDYTLMLS"
     gene            11560..11712
                     /locus_tag="PPM_RS07465"
     CDS             11560..11712
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="PPM_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_016820476.1"
                     /sec_met_domain="TIGR03731 (E-value: 6.7e-06, bitscore:
                     24.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKNEVAPKEVQPASGLICTPSCATGTLNCQVSLS
                     FCKTC"
     CDS_motif       11560..11631
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKNEVAPKEVQPA"
                     /locus_tag="PPM_RS07465_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11632..11712
                     /prepeptide="core"
                     /locus_tag="PPM_RS07465_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.70"
                     /molecular_weight="2493.9"
                     /monoisotopic_mass="2492.2"
                     /core_sequence="SGLICTPSCATGTLNCQVSLSFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKNEVAPKEVQPA"
                     /leader_location="[11559:11631](+)"
                     /alternative_weights="2511.9"
                     /alternative_weights="2530.0"
                     /alternative_weights="2548.0"
     gene            11790..13052
                     /locus_tag="PPM_RS07470"
                     /old_locus_tag="PPM_1422"
     CDS             11790..13052
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="PPM_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1422"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_013370169.1"
                     /sec_met_domain="LANC_like (E-value: 4.2e-56, bitscore:
                     188.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGDLQARSVEISKNITQKLIDLSYTEKIVHHRNNLSPSRGTAPW
                     NPGWLADGVPGVFVLLAEWGYLEPDQNWSEHVHTQLLYLHRNSLILLPDISLYYGSTGV
                     AYGVLLASNNRANYQQLLNQINDYIRTQWVKSPVINTITEFSKQMDVIHGLLGMGRYTL
                     EIPEDEKMCNLSHQLLDTITHFIPEYIHSASRRSSTSIHLGMAHGITGILALLVTALQK
                     KIGVKGLHEAIEHIADFLLIQIQEDQYGLYWPVNSQATSMNKTDNKEGMREIEGWCHGT
                     CGIAWTLLRAGMECSNEEWKKIAEQAMKSVFCLDDELLNALSPTFCHGLAGLLHMAHRF
                     YYFTGNKAALGFANQIALKLMNLYDEELPFGYQDLEGSIHVHNIGVLQGAAGIALSLLD
                     YGIGKEEPKYSGRWSELFLIS"
     gene            13110..13787
                     /locus_tag="PPM_RS07475"
                     /old_locus_tag="PPM_1423"
     CDS             13110..13787
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="PPM_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1423"
                     /product="winged-helix domain-containing protein"
                     /protein_id="WP_013370170.1"
                     /transl_table=11
                     /translation="MKQKFIAISSFGKIRHFFEALSTPENVQIIFYNSLNEALPWIDEQ
                     CIGVALNQDHLTLEDLSYWHTIKEKCSVPFIFLSYHRDDQRQLDLLKQLFSIASSEYQI
                     QREHEAISLSPNVIFDPAGKVIWKQGHEYMLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAYTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYRLNIFPKNLEVASCEETT
                     ALH"
     gene            13762..17016
                     /locus_tag="PPM_RS07480"
                     /old_locus_tag="PPM_1424"
     CDS             13762..17016
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820473.1"
                     /locus_tag="PPM_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1424"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_014599582.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.2e-197,
                     bitscore: 653.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.4e-17,
                     bitscore: 61.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6e-57, bitscore:
                     191.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRQLHYTDAHNLHREPRDKNERWFSACDYFLIRAPLLPIEQYYK
                     VFSDQDVDSHLSLEEITRRLKLVSQEAVIREAISLASPSLMQFLHYLNDDNASDDKGEL
                     QKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICRDATHLDIGTYHQHLKRARPDMEW
                     IYKMIRKMESDPVIFDQLKVFLNRTVMIKGDRAKLPFRPKHGAAEADDSAEMFSSIRLT
                     DVVRLTFEAAEHPIQVMELKELLLKAFPDATMEIIAHFLQQLVEQEFILSELRPPLMDH
                     SPFHYIFEKIKKMDMSDHWTDILHEIDILLRQYNQCTIGEGEKAYRELCGKMLDIIPVK
                     TPVQVDVKLAQEVTLPRHVLNDVALGAEVMCRLFSSPKTDELDDYLNRFLEKYGVYQEV
                     PINELFDEDWGLGIPKMYRTNEKKSMGMEAFKRNAVLFQWLSNAIANHDIEIVLSDEQL
                     EQLTISDNDDTSPESMEVYYSIFAESPEKVDSGDYRLLLGPSAGSNRAGKTFGRFLDMF
                     SDEFVQNFSEIYDHHQCFHPDALLSEMVFMPDQGKISNISLSKNLMGYEIVSGTTSSKD
                     EETTLHMDDLLIGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHIFRFLTDITNKELG
                     TWSYFDWGPLEQSPFLPRLVYKKIVISAAQWRLGKTALNISGLTEPQAREYLFHTWREQ
                     WNVPRYVYLTMGDNRLLLDLCNLFHVKELLREVSKMREGQELLLTECLGDPFHTPLHGT
                     AGRYMGEFVFPLKKKKIKVKPSIPSSQNHLDSQNFIAHTSSSIHRGILPGGEWIYLKLY
                     GVKERENDLIGLSLSQLQNNPGFEDWSQKSYFLRYVDPEHHIRLRFQGEPSQLWSAGLA
                     QLNQWAVELREEGLITHMVLDTYLPELERYGGQMLMDLAEQVFDVDSRWVIAYMAGIRS
                     KAFNLDIEIAAVINIIHYLSSFGLTIREQVDWLDERIDSKPYMKAFRDVKKALINAVES
                     DYEWIRQADPAAQVALLALVKKRQAMIQQYAQAITLAEKNHELTNHANDILGSIIHMHL
                     NRLLGVNREREMKCMALAKHTAANLLHRKGVHHVTV"
     aSDomain        14308..14592
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PPM_RS07480_Lanthipeptide_LanB_RRE.1"
                     /evalue="1.80E-19"
                     /identifier="RREFam001.1"
                     /label="PPM_RS07480"
                     /locus_tag="PPM_RS07480"
                     /protein_end="277"
                     /protein_start="182"
                     /score="61.2"
                     /tool="antismash"
                     /translation="VFLNRTVMIKGDRAKLPFRPKHGAAEADDSAEMFSSIRLTDVVRL
                     TFEAAEHPIQVMELKELLLKAFPDATMEIIAHFLQQLVEQEFILSELRPP"
     gene            17003..18904
                     /locus_tag="PPM_RS07485"
                     /old_locus_tag="PPM_1425"
     CDS             17003..18904
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="PPM_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1425"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013370172.1"
                     /transl_table=11
                     /translation="MSQSKGQTSDLVSLSYKNIFRTFLFWPRIFRLLWDTHPSFLIAIL
                     ITNLLKGAIPAAILLATRELINSVVAGASGGRFQPAFIAFGVLIGVNLVYDLINIGESF
                     FRKMFQSRLSNQVNIKIIEKAQKMSLQSFEDADVQNMLQRAQGEADYRPFEIFTQILAI
                     ISSVVTLFSTGAILIAWRWWAFLFIFLIPCLSFYSFLRIGQREFNVHFQRAGRQRESWY
                     LSFLVTRDNSFKEVKIFQLGDYLRKRYKTILEGFYREDKVLAVRRSYTSLAFQIVNQGA
                     CAFIIFMAIQATYVGQILVGNLVSLIQGITLTQSTSQSIVQGILSLCQNNLYIKQLFDF
                     LDMPEEAKIQKSVQPLPLSVIHSIEFRNVSFKYPNTEENAISNVSFTLHQGEKLAIVGR
                     NGSGKSTIVKLLTHLYSNFEGEIRINGHSIHELDKDSFRGKIGVVFQDFVHYEMSVRDN
                     IGFGHVASRENDEVIWAAIDKAGITDLVAGLPDKLNTLLGKWFEDGQQLSGGQWQRIAI
                     ARAFMRNADIYVLDEPSSFLDPHAEKEVFQKFGQLVHERIGVFISHRLSSARMADTIIL
                     MEEGRIVEAGSHEHLMDMDGVYAEMFRLQASSYLSQGESDLEEEKLSPSLVRATGGS"
     gene            complement(18943..19272)
                     /locus_tag="PPM_RS07490"
                     /old_locus_tag="PPM_1426"
     CDS             complement(18943..19272)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820471.1"
                     /locus_tag="PPM_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1426"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_013370173.1"
                     /transl_table=11
                     /translation="MNINPNVLYIIIGAMIVTAIPRIIPFVVLQKLTLPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLIAVLPTLVTALWSKNLLATVLVGIVSMAVVR
                     LLWMG"
     gene            complement(19269..19994)
                     /locus_tag="PPM_RS07495"
                     /old_locus_tag="PPM_1427"
     CDS             complement(19269..19994)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="PPM_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1427"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_013370174.1"
                     /transl_table=11
                     /translation="MSIASELSGTKHDSLSFLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIGLMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLRKNIGIGILLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISQPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLSWWVPSH
                     IAVIVATIITATIGVLTDK"
     misc_feature    20014..20027
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     misc_feature    complement(20116..20131)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.68"
                     /tool="antismash"
     gene            complement(20340..21578)
                     /locus_tag="PPM_RS07500"
                     /old_locus_tag="PPM_1428"
     CDS             complement(20340..21578)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426681.1"
                     /locus_tag="PPM_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1428"
                     /product="MFS transporter"
                     /protein_id="WP_013370175.1"
                     /transl_table=11
                     /translation="MNPQTRKSRHMYTMQLATIFIGFIVFGISENIKGPAIPRIQFDFN
                     LDEQQLGTLLSLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPF
                     FASSYFLMYIGNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSL
                     TVFGHTLDWRGMYLAMLSLCLLPIVAALLSTFPGDDLQHEERTSLKTLTRDPALWMMVM
                     ILSFGVVSELAVGGWLVNFLEKAYSWSTVKASSMLSAFFLTFSLGRLLLGPLTDRMGFV
                     LSTILFSAFSAICTFAAIAGGERLAFLFATSGAGIAMIYPTVMAFIARRYPKDSDTAIT
                     FVVTLMGIGSVIGNYVIGWVIEGVKIVYGATTELGILRGLQAGYGVIGLCAAICAVSGI
                     ILYGYLKKRQELI"
     misc_feature    21684..21698
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.47"
                     /tool="antismash"
     gene            21980..22528
                     /locus_tag="PPM_RS07505"
                     /old_locus_tag="PPM_1429"
     CDS             21980..22528
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="PPM_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1429"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_013370176.1"
                     /transl_table=11
                     /translation="MDSMQYIIGSNLAQIRKTRGLSLDKVAELTGVSKGMLAQIEKGRS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRRADLHPVIDEGGNYFVYPVFPYHSEK
                     KFEVFTVSLKPGFTHKAEEHLGEETILMIRGEMYFEMQGQQLKLSAGDAVQFQGSDFHT
                     YRNDSDEDADFYVLIYYAD"
     gene            22628..23143
                     /locus_tag="PPM_RS07510"
                     /old_locus_tag="PPM_1430"
     CDS             22628..23143
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - acyl-CoA hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /function="acyl-CoA hydrolase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599583.1"
                     /locus_tag="PPM_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1430"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_014599583.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRTNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQIQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDFPWEV"
     gene            complement(23251..24717)
                     /locus_tag="PPM_RS07515"
                     /old_locus_tag="PPM_1431"
     CDS             complement(23251..24717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="PPM_RS07515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1431"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_013370178.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLTILLSLSIFQMFSPKIASATSANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     VELNVSNIERPKVIYNEKTRKYVLWMHKENGINYNEARVAVASSDTVDGDYTYQGSFRP
                     LDYDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTMNFGDGTTYGSQSAYVIPVEGT
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSINVDTASGVVEGIT
                     TPMVIDPDAYYQLVSRKSNKPLGIIGNATIDGADLEQRANSGAPSQQWQLKDAGGGYYK
                     IVNRNSGKLIGVESGATADGAVIEQWNDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATGDGAKAIQWGDNGGTNQHFRVVKVE"
     gene            24944..25642
                     /locus_tag="PPM_RS07520"
                     /old_locus_tag="PPM_1432"
     CDS             24944..25642
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 3.6e-12. Score:
                     38.2. Matches aSDomain: nrpspksdomains_PPM_RS07520_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="PPM_RS07520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPM_1432"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_013370179.1"
                     /transl_table=11
                     /translation="MEIYAIDTSKPEAENHYELLVNRVSLAKQHKLDRFLHREDALRGL
                     YADVLLRWLACRQLKIPNASLQFTYNAFGKPSLLNAPAFHFNVSHSGKWVVCAIDDHPL
                     GIDIEQLRPIDFEVGRVCFSDTEYDALMHQDAESRLSYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELETQPSIGFTTEGFTTVYCHFKQYELDPDYKMAVCAAHDDFAQVVQQVDIN
                     TLRLEVATLA"
     aSDomain        25253..25426
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PPM_RS07520_ACPS.1"
                     /evalue="3.60E-12"
                     /label="PPM_RS07520_ACPS.1"
                     /locus_tag="PPM_RS07520"
                     /protein_end="161"
                     /protein_start="103"
                     /score="38.2"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDTEYDALMHQDAESRLSYFYDLWT
                     LKESFVKAEGQGL"
ORIGIN
        1 accaggacat tgcccgcttg tttttatgga caggaggtgc ggtgctggtc ttaagcttta
       61 ttcttggctt aggctatgtc agccgccaga cgagggacat cggacgactg actcgcgctt
      121 ctgagcagat ctcggcaggg cactatccag aagccagatt gctgcgacgg caggacgagc
      181 tgggaaggct ggatgaaggg atgctccaga tgagtcatgt gatccgggca agtattactg
      241 cgctcgaaaa tgaaaagctt cggctggaag aagcggttcg gcgtttgaga gagctagagc
      301 agcagcaaaa gacctttatt ggcaatatca gccatgaact gaagactccg ttgacctcta
      361 ttcaggctta cgctgatttg ctggatatgt atggggatga tcccgaattg gtgcgtgaag
      421 ccagagaaag tatcggtaag gaaaccaaac ggttgtatga gcttgtcgag gattcactga
      481 gactatctgt gctggacaaa tatgattttg aattacatac ggaggaagtg gagctgcatt
      541 tgctgctcga agatgcaggt agccgaatcc gggggaaagc tgcggcgcgt ggactgaatt
      601 tttcgatgga taccattcca gccaaggtgt gtggagaccc taagcatctg atgcatattg
      661 tgctgaattt gctggataat gcagtaaaat acaatcagga cgaaggctgg attacgttat
      721 ctaatcgagt ggaaaaggac accgtgatag tgtatatacg caattccggt ccatggattc
      781 ctcgggaaaa atgggacatg atttttgagc cgtttgctac cttaagtcgt gatcgttctc
      841 gtcaagacag tggcacggga cttggcctgc ctttggcacg cagactggcg gagcgcatgg
      901 gtggagagtt gcagctcaca gcttcagacg aaaccgggtt ggaaaatggc aatggtcatt
      961 caggtgcaag tggcaatgaa ttttcgctca ggctacccct gttggttcac gatggcttcc
     1021 agtagttgga ccgctcgata gctatagaac tgaaaatgtt gtcttattta caatttggaa
     1081 acaattcgat gtattcacga gatgttcagg cattaagctg ggggtaacgt taacaaggag
     1141 gccgttgtac atgatgaaga aaaacctaga cagccacggg aaaaagaacg gctttcctcg
     1201 tctcaaacat ccctatgcac gctttttcag acacaaagtc acaggattgc tcatgactgg
     1261 cttgatcgct ggaggattgc taggcggctg cggcataaaa agcgcaggag agacaattcc
     1321 aacatccggt atgaaaccgg ggcaaaagct tactgtgatt gacatggagg cagctcggca
     1381 gcaagtatcg gacgagctgg tggtacagtc catcgacaag ctgggagatg tctacgcgag
     1441 gtcatggctg agtgatgaag agctgattgt ggaacgtcag aatcagttat ggattcataa
     1501 tgtaaagacc aataaggaac gagttttaac accaggtcgt aaggctctac agttacttgc
     1561 tgtggtttct ccggatcagc gccatgtctt ttttacggag ggcagcacca gcagcaagta
     1621 tgatattcag ggctatattt tagagctaag cagcggcaag gttacatcgg ctggccagct
     1681 ggacatgact aacgaagtga gctggggcga taaggatcat ctcattacag gtacaccaga
     1741 cggtaagata catctgattg gactggacgg caaagctgaa gaattgagtt ttcaagatcc
     1801 aaatcactca gaattaattg ctcatgtcga aaaagtgggt aacgccatat tttatacagg
     1861 caatgataaa caagggtatc cggtgctgaa tcggttcact ctcaatcatc ctcaagctgt
     1921 gaccattgca gagggggcca tgtcttttgc agtgtcgctt gatggtaaat ctattgccat
     1981 tgaaaagcgg aaatggaata catccgaacc tgctcgtatg atcattttgg atgaacaagg
     2041 caaagagaaa gggatcgtgg gtcaagggac tttaatgagt cgtggaagct ggtccaacga
     2101 cgggtccaag cttgcttttt ccatttatga tgaggatcag caaggtatga gagggttgta
     2161 tgtgtttgac caatccacgg gtaaaaccac tcccgttacg accgatatcc agtcctatga
     2221 cagtccaaca gtgtggagca cttccgcccg gtttttatcc atgtaccaga acatttcgga
     2281 aggtggaaaa caactgaatc agagctacat cgtcgaattt aagaaaaagc agtaaaaaaa
     2341 ggcgcatttc cttcttcgga atgtaccttt tttaattagg ctggttattc gattgtgtat
     2401 cactatacaa atttgcgatg gtgtttctta ccgtcatatg aaaataaggc gagcttacct
     2461 tcaatcattg tttccaaatg aacggtgcgc ccccatagct gatatacata cggaagcgta
     2521 cgctccatat attttaaatc cagttcaatg ccttcatact ggtgcttgag ttttaattca
     2581 cctgtatgca gataatctcc gtcttcaaca acgatataag gggagcctcc atttacacgt
     2641 gagaacacaa gctgatcccg tatgttttcc caggatttat cggtaatttt ccaatccggt
     2701 ccccgtttct caaacacgta cagatccaaa tcctccgtta gttgcttggt catgtaattg
     2761 cgtataaagg aggtatccga gtcaaactct cgcacctcga atattttagc tcgaccttcg
     2821 cccggtttgc gtccttggcg ctcttgctcc tcgcgggtcg ggttatccca tcgcttttca
     2881 atatcttcaa atattttcag tcccaaataa tacggattca agctttgctt ggaaggctgc
     2941 acaacggagg cgttcagcat ggcaaattca acggtttcat ccccagtcaa atccagttct
     3001 ctgacaatcc gttgatgcca ataggaggcc cagccttcat tcatgatttt ggtctccatt
     3061 tggggccaga aatacagcat ttcgtcccgc agcatcgtca tgatgtcccg ctgccagtcc
     3121 tccaatacct cggagaattc ctgaataaac cagacaatat ctttttcagg ttccggtggg
     3181 aactggcgta ccttaatacc ctcggtctcg gctgaatcat gctgctttac tgtgtccagt
     3241 gaccacagat catcgtaagg tccgatggga cgctggtgtt ttttaggttc tttttgctcc
     3301 ttgattttga gttccatgta gcgttgttta tccagatgcc ttggtttgat gagctgtggg
     3361 tctacatgtt cctgtatcgc cagtacagag tcaatgaagg attccacggc ctttgagccg
     3421 tactccattt catagctgct gatccgttct gcggtggcag acatgctctc taccatattg
     3481 cggttggagg ccgagaagcg ggcgttgtgt ttaaaaaaat cgcagtgtgc cagtacatgg
     3541 gcgacaatca gtttattttg caccaaagaa tttccatcca gcaggaaagc gtagcaggga
     3601 ttggagttaa taaccagctc atagatttta ctcaatccaa aatcgtactg cattttcatc
     3661 ttgtgaaatg ttttgccgaa actccagtgg ctgaagcgcg tgggcatacc atacgccccg
     3721 aatgtgtata caatatccgc cggacaaatc tcataccgca tcgggtagta gtcgagcccg
     3781 aatccatctg caatctccat aatttctgat atcgcgtact caagctcttt ctgatcggtg
     3841 ctcatcctac cgttccccct tcccgtttgc gaaaaaaggt acgtaaggct tggtatacct
     3901 cacctttttc cttgatgaca tagtacataa actgatccgt tttaatattc ttgtaggctg
     3961 acatcagcgt actgctgcga ttatattggt tcacctctcc atagccgaac atattgctgc
     4021 gcttcataag ctcctcgatt agtttcacac accgttcatt gtctgagctt aggttatcgc
     4081 catcggagaa atggaaggga taaatattat aagtcgaagg aggatagcgt ttatcgataa
     4141 tctccaatgc tttcaaatag gcagaagagc agattgtgcc gccactttca ccgcgagtaa
     4201 aaaattcttc ctccgtaacc tccttggctt cggtatgatg cgcaagaaaa acaatttcca
     4261 ccttttcata ttggcgacgc aaaaagcggg tcatccagaa aaagaagctg cgggcgcaat
     4321 atttttcaaa agatcccata ctgcctgagg tgtccatcat agcgataatt accgcattgg
     4381 attggggaat ggtcttctct tcccatgttt tgtagcgaag atcgtccgga ctaatatgat
     4441 gaatgcccgg attcccctca cgcgcgttgc ggcgcagatt ttcgagaatc gttcgtttct
     4501 tgtcaatgtt cgcttgcatg ccttttttgc gtatatcatt gaatacgata gattcaacct
     4561 caatttgatc cttatctttt tgctgcaaat gcggcaattc catttcctca aacagcatat
     4621 cttcgagttc ctctatgctg acttctgttt ccataatatc gtgtcccggt tggtcgcctg
     4681 ctttctcacc tttacctggc ttttgggaag caggatcacg tccgatgaca tctcccacct
     4741 gactgtcgcc atccccttgg cctacatgct tttgcttttg gtagttataa atgaagcgat
     4801 attcatccag actgcgaatg ggcactttga taatctgttg accgtccgac attataatat
     4861 tttcttccgt aatcagatcg ggtagatttt gtttaatgac atctttgacc ttctgctgat
     4921 ggcgttgctg gtcctggtac cctttgcgat gcagcgacca atcttcgcgg gatacgacga
     4981 atgaatatgg ctggcgtggt tccgtcattg ttaggcaccc cccaagtgga tacacggcac
     5041 agtttggcct tgttggttat taagtatatt cacggggatg tacgatatgt gatggaactc
     5101 gatttaaatt ctgcccgttt gcttttataa tgaaagtaaa aaatgtaaaa aaagaatgga
     5161 gaaccttggt tatggaagaa attgcagtgc ttatcgtaga cgatgaacag ggactgcgag
     5221 atatgctgac aaaagtatta aaaaaggaag gatttcttca tgttaagcat gcagccacgg
     5281 gccaagaagc gctgcaaatc gtgatggaat ctcgtattga tgtgattgtg cttgatgtta
     5341 tgctccctga taacgatgga tttgaggtat gtcgtcagat gcgtctatac acggaagttc
     5401 ctattctttt tttgacggca agagatacag atctggacaa attaatggga tttggtattg
     5461 ggggggacga ttatatcacc aaaccgttta acccgttgga agtcgttgca cgtatgaaag
     5521 ctcgaatgaa gtatcgaaat gtgacaacag cggatatgaa gcctgcttta caaaccttag
     5581 attttggata tttttgtctg gagctggaat caggtgcatt gtatgtgcaa gaccaagagg
     5641 tcgattgtcc tgcacgtgaa tggctactgc tggtattttt gtgtaagcat cctaaccgta
     5701 tattcagtgt gcgtcagcta tacgaagcaa tatggagcga gaccttcctt ggtgatgaaa
     5761 agacagtagt cattcatatc tctcgtttgc gaaaaaaaat agaacctgat cccaagcacc
     5821 cgcaattttt agttaatgta agagggctag gttataaaat gatatcagtc aagagggggg
     5881 agcaagaatg aactctctgg tcaagatatc ctttcgtttt ataaaagtaa cattatgttt
     5941 tgcactagcc tatgttcttt gttttcttat ctgcactgtt atatatattt ttataaaaag
     6001 tacatttggt acatctcata atatgaatat tgatctcttc tggataggac ttggaatcgt
     6061 gcagagcatt gtgttcatag ctgtctatgg atggtatata ggcaaaccct tggtgtatgt
     6121 aattaaatgg attggaaata tagcaacagg ggaattccaa gcgccgctaa gtgagctaga
     6181 actgccagag cgcaaaaaaa atcagagcaa taattataag cctccgtatc aattgtataa
     6241 agaagttttt gaacaaatga acatcttatc tgctcaattg cgcagcaatg aggaagagag
     6301 aatggaaata gaaaagcgaa aacagcagtg ggtagcaggt gtaagccatg atctcaaaac
     6361 acctttatct tatattgaag gatatgcagc catgctgact gctcaagagt atgattggtc
     6421 cgaggaagaa aaaagaagct ttagtatggc tatcagtgag aaagtgacgg aaatgaagca
     6481 gttgattcag gatttgaatg cttctatgca gctcaaggag ggtgccttgc cgatccagtt
     6541 aaagaaggag gacattgtgg agtttctccg caatacggtc atagatatcg ctaaccatcc
     6601 ttcggccgag cagtacgaat tttcttttat gtcattggag gcagtatgtg tcgtgccctt
     6661 cgatagtaaa ttattaggta gagcgttgaa aaattttttg atgaatgcaa tcattcataa
     6721 tcctccaggt acacatgttt caatggaagt aaacaaagag agcgataagc ttcatatttc
     6781 tatcgaagat gatggaatag gaatgaatcc aactgaattt atacagatga caccttccaa
     6841 agagcatggg atacctattg ccaaaagctt tattgaagcc cataacggaa cgcttcatat
     6901 tcttccggga agtcaagagg gtaccagaat agaaattacg ttgccactga atatgtaact
     6961 ctttaacatc tctccctcac attttggagt tcgctcgttt ttttgcctgt tgtttaggaa
     7021 ctgtttactt gatgttaact ttctttcagt aaactgtatg taactaactt cagcattaaa
     7081 agtcgagagg agagcaggaa atgtctgaat atgtaatacg tacacgtcag ctaaccaggc
     7141 gttttggaaa aagggaattt gtcaaacaaa taaatctcca ggtacctggg aagcaaattt
     7201 acggattttt gggaccaaac ggggcgggga aaacaaccac gattcgtatg ctactcgggc
     7261 tgattaaatc cacatccggg gatattgaga tttttgggaa aaagctcaag gatcatcgca
     7321 tggaaatatt aaaagatgtg ggttctttgg ttgaatcacc tgcctattat gcccatttgt
     7381 ccgcatatcg aaatttagaa atcgttacaa cgatgcgtgg gttgccgact cgaaaaattc
     7441 ataaagtgct ggatttggtg agattaagca aggatgcgta tcgtccggta aaaggatact
     7501 ccttggggat gagacaaagg ctaggaattg ccatggcgtt gattgctgat cccaaattgt
     7561 tgattcttga tgaaccgacg aatggtttgg acccgtccgg tattcaggaa attcgggagt
     7621 taattatgag cctgcctgat gcttacggaa tgacggtatt ggtttcgagc catctattaa
     7681 gtgaaatcga acagatcgca acctatgtag ggattattaa tcaaggggaa atgattttcc
     7741 agggaacgat gaaagaactt acagacaaaa gcaagcctca attattcatt gaaacccaaa
     7801 atcctgttca ggctgctgga gccctgatgc agcatggatg gattgccgga gctgaatcca
     7861 tggagcaaaa agaggtcata actcctatag tagaccgtga gcagtcatcg gagatgatca
     7921 aagtgttggt ggagcacaat caccccgtct accgggtaag ggagaagaaa aaaacattgg
     7981 aggaaatatt cctggagctg actggtaagg agcgaagctt atgatactcc aagttatcaa
     8041 ggcggaagga tataagctga aaaaaatatg ctggtggctt cctctaatac agggctgtgt
     8101 tcttacagga atgactgccg tggaatggta tctctacttt cgccaggggc caggcggggt
     8161 ctatgctggt tttgccgtta tgtttatgtt catctcattt gtgatgttgc ttggttgtac
     8221 acttttggca agcataatgg caggtacaga gcacgatact caaacatgga agcagttgat
     8281 ggccatgcct gttcctagaa gctatattta tgtatccaaa atagtgtgga tcgtgatttt
     8341 gcagcttggc accgccttga tcacgatagc agggatgagt ctcatctggg tgttgtatac
     8401 aaacgagccc attccttggc gagttatgct gctgcagccg attaatgcca gcttggctac
     8461 cctgcctgta cttgcaattc aactttggtt gtctaccctt tttactaatc aggcatttcc
     8521 gttagcgttt ggcatatttg gttctattgc cagtttgttt ttggcacgaa caagtattct
     8581 ttggattaaa ttattacctt ggtcgtatcc ggcactatca agtcctctga ttaaggaata
     8641 cgtaatgtgg gtggtcattg ctttatgtgc agggatcatc ttcacaggac tcggtactct
     8701 acagtttaca aagcatgaat tcaaatagag aggggaatct gcatgggatc cattttacgc
     8761 gtggaagcga tgaagcttca atgggtcatg gtatggattc tcattatatt ggatgcggtt
     8821 atcaattctt taatgggagt cctggaactg aacgatttga agcagtttta tgagcctagc
     8881 tggttaatgt tatacaccta tgcggcgcat tttcactcga tgttttttta tccgctttat
     8941 tgtggaatta ttgcttctct tttgtgtgca tacgaacatc gagatggagg atggaagatt
     9001 ttattgagca gcccgtatcc ccgtcagcga atctattatg caaaatatat attgctcatt
     9061 ctcatactgt ttcttgatca gcttacattc atagtaggat attttgcagg tgggtatata
     9121 gcaggtgctc caggagaaat cccttggact ctcgttcttt ctaccggatg gggagggtgg
     9181 ttcggaattc ttccattggc agccctccag cttatgcttt cggtaaaaat ccgcaatttc
     9241 ggagcttcac taggaatggc tatttgctgt gtagtgccta atattgttat gacaggcttt
     9301 cattcttcta taggagcatg gtttcccttt acgattcctt attatattat gttgccacaa
     9361 acagcgagct atgctcccag agtcgagcct tatagtcttg gtttgattgt actttttacg
     9421 tttttagcct atctatatgg tggaagaaaa atgtttgtga atagggactg gttgtagcta
     9481 ggatatcatg aggctgtaat tcatctcttt gttctcagaa acatttatta aaatagcagt
     9541 aatctctgca aggccttcaa gtatgtcgta tttgaaaaat aatatggctt aagaattaaa
     9601 taagatatcc gtaaagatca tttaagagtg agtaccttat gattaaaatg aaaaaaaaac
     9661 agaaaggaga tgatgtaatg aaaaatcaat ttgatctgga tttgcaagtg accaaaagtg
     9721 agagtgcttc taaagagctt caagcagaca gcggcattat ttgtactcct acttgtttaa
     9781 catctatttt aaactgctat actagcattt cacattgtgg accttgttga taactaaaat
     9841 ttgaccatga aggcacggtt caaaaaccgt gcctttagtt ataaatttaa tttcctttac
     9901 tactcgcttt aatagcatag cgtcttcaat ataagggttc gtccttaggg ttctgatata
     9961 aaaataaaaa tggatagtcc taaatagcgg ctggttttag ctaagataac atcagagtgt
    10021 aatcccaggg catctctttg ttctgagaaa cacttaataa cgcagaagca atcccggcga
    10081 cgccttcaag caggcctgct tttgtcagcc aggccaaaga gctgtctgcc cttggctcgg
    10141 ggtccagata tccaagtgga ctatcggctt gaaagcgatc tatcagctga ctggttaatt
    10201 gttgaataag cgggataaac gctggttcct tactgtgaca ccacattcgc caggagatcg
    10261 taagcaaccc ggcaagacca tgacacaatg cagaggagtc catttcccgc ttagctacct
    10321 cataggaaat ggcaccgata caggccttca cagccatttt ttgcagtact tcatcatgaa
    10381 gagccttccc ggcaagaaat aaggaacagg caacgccagg agtaccgtaa caccaggctt
    10441 ctcttgctcg atttaaatca aactgtaaag agcctgtttc agcctcaaaa ggaacaatat
    10501 gaggccagta gtagccgtat gtatcctcat ttttatactt aagcagccat tccgtaatcg
    10561 tttcaatcgc ttgatattgg ccttttactt caattccaga gttgtaagct actgatagta
    10621 aggccaatgg tccgggaatg ccgtgtgcca ttccgcaatt gaagttaccc ataggatagt
    10681 tgcgtttatc tcgatccaaa aactgaaact tttgcggaga gtaccagcct ggaacatagc
    10741 ggttgtggat ttttatagga tatgtgagat cggttagaaa ttgaagaata ggctcgacaa
    10801 gaggagtaca actaggatcg gttgagttca tcacaatata tctcccaatc ccggtggctc
    10861 ctgaaatcgt atcaaaggat tgcaggggca tcccttcgtg cagagctaat tgtgctgtat
    10921 tcaattgcag ccattgttct gtcagaggaa tcatccattc atgtatttgc tgtaaaaaat
    10981 gactatagta ttcgccatga ttggaggctt ctctcacgga agaagcgatg ccggtccagc
    11041 cgctgtaaag tgagacatca tttagaccac ttttagcaag cgaagcttga atgtgcttca
    11101 tattcaagta gatagcctga ttccaatcat acgtggagtc tgaagcacga cattgagata
    11161 gtaaaaaaat attacccgga tatccgtgtg aaagcgaagt ctcgccccat gggtgatatt
    11221 tggtttcggg tgaaatattt tgctctgcgt ggactgcttt gtagactgat tcaggattac
    11281 tcaggcgcaa ggcgattgtt gtactgaagt cttttgcctg taattgatcg catacttcca
    11341 taacaaactg gcccgttttc atacgaatgc ccctttcatt ttttccttca ttatattgtt
    11401 gctcaaagct ggcgagttgt ccttaaaaat tctaaaaagt aacgaggaat tatcttaatt
    11461 gcattcacta aatttaagat ggatgtaaga gatttataaa gtctagttaa gattgtataa
    11521 cttataataa aattgtaaaa aataaaagga ggtagcaaaa tgaaaaatca atttgatctg
    11581 gacttgcaag tagccaaaaa tgaggttgct cctaaagagg ttcaaccagc tagcggtctt
    11641 atctgtactc cttcctgtgc aacaggtact ttgaattgcc aagttagcct ttccttctgc
    11701 aaaacgtgtt aataacgaga aaacatggta caaaaggcac ggttttataa ccgtgtcttt
    11761 tcccggttat aaaaataggg ggaggaatta tggttggaga tttgcaggca aggtcagttg
    11821 agatcagcaa aaatattaca caaaaactga tagacctatc atatacagaa aaaatagttc
    11881 accatagaaa caacctttca ccttcgcgtg gaacggcccc ttggaatccc ggctggcttg
    11941 ctgatggagt tccaggtgta ttcgtgctgt tggccgagtg gggttatctg gaacctgatc
    12001 agaattggtc agaacatgtg catacacagt tgttgtattt acatcgcaat tctttaatac
    12061 tactgcccga tatatctctg tactatggtt ctacaggtgt agcatatgga gtattgcttg
    12121 cctcaaataa cagagctaat tatcaacaac tgttaaatca aataaatgat tatattcgta
    12181 ctcaatgggt aaagtcaccc gtcataaata caattacaga gtttagcaag cagatggacg
    12241 ttatccacgg cttgctcgga atgggcagat acacattaga gattcctgaa gacgaaaaga
    12301 tgtgtaatct gtcccatcaa ctattagaca ctataacgca ctttatacct gaatatatac
    12361 attcggcatc aaggagaagt tcgacttcga ttcatctagg tatggcgcat ggcatcaccg
    12421 gaatccttgc actgcttgtc actgccctac aaaaaaagat tggagttaaa ggattacatg
    12481 aggctataga acatatagcc gattttttgc ttattcaaat tcaggaggat caatatggtt
    12541 tgtattggcc tgttaactct caagcgactt caatgaacaa gacagataac aaagaaggaa
    12601 tgagagaaat tgaaggctgg tgccatggaa cctgtggaat agcatggact ttactcagag
    12661 caggaatgga gtgtagcaat gaagaatgga aaaagatagc cgaacaagct atgaaatccg
    12721 tattttgctt ggatgatgag cttttaaacg cgctatcccc cactttctgt cacggattgg
    12781 cgggtttgct tcatatggct catagattct attacttcac tggtaataaa gctgcattag
    12841 gctttgccaa ccaaatagca ttaaagttaa tgaatctata cgatgaagag ctcccatttg
    12901 gttaccagga tttagagggg agcattcatg ttcataatat aggagtactg caaggggcag
    12961 cagggattgc gttaagctta ttggattatg gaatagggaa ggaagagcct aaatattcag
    13021 ggagatggag tgaattattt ctgatttcat aaaagaactg tcttaactct ttacctgaag
    13081 cattggtttt atagttaggg gggggttaga tgaaacaaaa atttatcgct atatcatctt
    13141 ttgggaaaat tagacacttt tttgaggcgt taagtactcc ggaaaacgtc caaataattt
    13201 tttataattc gcttaatgag gctttaccgt ggattgatga gcagtgcatc ggtgtcgctt
    13261 tgaaccaaga tcatttaacg ctagaggatt tatcttactg gcatactatc aaagaaaaat
    13321 gttcggttcc atttatcttc ctgtcctatc atcgtgatga ccagaggcaa ttggatctcc
    13381 tgaaacagtt gttttcaatc gcttcatctg aatatcaaat ccagcgagag catgaggcta
    13441 ttagtctatc tcccaacgtt atttttgatc ctgctggaaa agtcatttgg aagcaagggc
    13501 atgagtatat gctgacgatg atggaatttc gattattgat gtatctcctt acagcgaaag
    13561 agtgtgcatc cacgattgat cacattatag acagagtatg gggagttgat gcttatacta
    13621 catctaatac ggtgtatgtg catatccgaa aattaagaga gaaaatagaa gatgatccaa
    13681 gtcatccgaa aatattggta acatgccatg gaatcggtta caggttgaat atatttccta
    13741 aaaacttgga ggtggccagt tgtgaagaga caactgcatt acactgatgc tcataaccta
    13801 catagagaac cgagagataa gaatgaacga tggttcagcg catgtgatta ttttctaatc
    13861 agagctccat tactcccgat agagcaatat tataaggtgt tttcggatca agatgtagat
    13921 agccatcttt ctttggagga aatcactcgt cgactaaagc tggtttccca ggaagctgtt
    13981 attcgagaag ctatttcatt ggcctctccg tcccttatgc agtttctaca ctatttaaac
    14041 gatgacaacg cttcggatga taaaggagag ttacaaaagt atgagaagac gctgaatagc
    14101 ttttatcgtt attttattcg gatgactacc cgaacaaccc catttggatt attttcaggg
    14161 gtggggcaag ggatttgtag ggatgctacc catttggaca taggtaccta tcatcagcat
    14221 ctgaagagag ccagacccga catggaatgg atatataaga tgatccggaa gatggagtct
    14281 gacccagtca tatttgatca actaaaggtt ttcttaaacc gaacggttat gatcaagggc
    14341 gatcgtgcca aattaccatt tcggcctaaa catggagcgg cagaagccga tgattcagcc
    14401 gaaatgttta gttccattcg gcttacggac gtcgttcgcc tgacgtttga agctgcagag
    14461 catccgattc aggtgatgga gcttaaagaa ttactattga aggcattccc cgacgctact
    14521 atggaaatca tcgctcattt tttgcaacag cttgtagagc aggagtttat tttgagcgag
    14581 cttagacctc cactgatgga tcattcacct tttcattaca tatttgaaaa aattaaaaaa
    14641 atggacatgt ctgatcattg gactgacatt ttacacgaaa ttgatatttt attacgtcaa
    14701 tacaatcagt gcacgattgg agaaggagag aaggcctacc gggaactatg tggcaaaatg
    14761 ctggatatca ttcctgtaaa aacacctgta caggtcgatg tcaaattagc tcaagaagta
    14821 acgttgccaa gacatgtgct caatgatgtt gcattaggag ctgaagtcat gtgcaggttg
    14881 ttttcatccc ccaaaacgga tgagctggac gattatttaa atcgtttttt ggaaaagtac
    14941 ggcgtgtatc aggaggtccc tatcaatgaa ctgtttgatg aggattgggg acttggtata
    15001 ccaaagatgt atcgtaccaa tgagaaaaaa tcaatgggca tggaagcatt taaacgcaat
    15061 gctgttctct ttcaatggct ttcgaatgcc attgccaacc atgacataga aatcgtcctt
    15121 tcagatgagc agttggagca actgacgatt tccgataatg atgacacttc cccggaatct
    15181 atggaggtat actacagtat atttgccgaa tcacctgaaa aagtcgattc aggagactat
    15241 aggcttttac ttgggcccag cgctggttct aatcgggcag gtaaaacttt tggacgtttt
    15301 ctggatatgt ttagtgatga gtttgtacaa aatttttctg aaatatatga tcatcaccag
    15361 tgttttcatc ctgatgcgtt attgtcagag atggttttta tgcccgatca ggggaaaata
    15421 tcaaatatat cactgagcaa aaatttaatg ggatatgaaa tcgtgtccgg aacgacctct
    15481 tctaaagatg aggaaacgac attacacatg gatgatttat tgataggtgc aactcatgac
    15541 cgtttctatg tcaagtccag acgtttgggt aaagaaatta ttcccctgca aacccatatg
    15601 cttaattaca agctttcacc gcatatattc agattcttga ccgatatcac caacaaagag
    15661 ctcggcacat ggtcctactt tgactggggg ccactagagc agtctccttt tttgccaaga
    15721 cttgtatata aaaaaatcgt tattagtgct gcacagtgga ggcttggcaa gactgcgttg
    15781 aatatttcag gtttaactga gcctcaagca agggagtatc tttttcatac ttggagagaa
    15841 cagtggaatg tgccacgcta tgtttattta acgatgggag ataaccgact tttattggac
    15901 ctgtgcaatc tcttccatgt caaagaattg ctccgtgagg tgagcaagat gcgggaagga
    15961 caagaattgc ttcttaccga gtgtttgggc gatccattcc ataccccgtt acatgggacc
    16021 gccgggagat atatggggga atttgtgttt ccgctcaaga agaaaaaaat aaaggtgaaa
    16081 ccgagtatcc ctagttcaca aaaccattta gattctcaaa acttcattgc tcacacttct
    16141 tccagcattc atagaggtat acttccaggg ggcgagtgga tttaccttaa attgtacgga
    16201 gtcaaggaaa gggaaaacga tctgattgga ttgagtttaa gtcaactcca aaataacccg
    16261 ggatttgagg attggagtca aaaatcttat tttttgcggt acgttgatcc cgagcatcat
    16321 atccgtctgc ggtttcaagg agagccgagt caactatgga gtgctggctt ggcgcaatta
    16381 aatcagtggg cagttgagct gcgtgaagaa ggacttatca cccatatggt actggataca
    16441 taccttcctg agctggagag gtatggagga cagatgctta tggacctggc agaacaggtt
    16501 tttgacgtgg atagccgatg ggtcatcgcc tatatggctg gaattcgttc caaagctttc
    16561 aatctggaca tagagattgc agctgtgatt aatattattc attatttaag cagctttggt
    16621 ttaacgattc gggaacaagt ggactggcta gacgaaagaa ttgacagcaa gccttatatg
    16681 aaggcgttca gggatgttaa aaaagcattg attaacgctg tagaatcgga ttatgaatgg
    16741 attagacaag cagatccagc tgcacaggtc gctttgttgg cacttgtaaa aaaaagacag
    16801 gccatgattc aacagtatgc tcaagcgata accctggctg aaaaaaatca tgagcttacg
    16861 aatcatgcga atgatatttt aggcagtatc attcatatgc acctgaatcg tctgcttggt
    16921 gtcaataggg agcgggaaat gaaatgtatg gctttggcaa agcatacagc ggccaacctg
    16981 ttgcatcgga aaggagtgca ccatgtcaca gtctaaagga caaaccagtg acctggtttc
    17041 tttatcctat aaaaatatat ttcgtacctt cttattttgg cctcgtatat tcaggctgct
    17101 ttgggacact catccttcct ttttgattgc tatactcatt acaaatttat tgaagggtgc
    17161 cattcctgcg gcgatccttt tagcaacaag agaattaatc aacagtgttg tggcaggagc
    17221 atcaggagga cgttttcagc ctgcttttat agcttttggc gtcctaatag gtgttaattt
    17281 agtgtacgac ctaatcaata ttggtgaaag cttttttcgt aaaatgttcc aaagtcggct
    17341 atccaatcag gtaaatatta aaattattga aaaagcacaa aagatgtctt tgcagtcatt
    17401 tgaggatgca gatgtgcaaa atatgcttca acgtgctcag ggagaagcag attacagacc
    17461 atttgaaata tttactcaga ttcttgctat tataagcagt gttgtaactt tattttcaac
    17521 aggtgctatt cttatcgcgt ggagatggtg ggcattctta ttcatttttc tcattccatg
    17581 cttatcattc tattcttttt tacgtattgg acaaagagaa tttaacgttc actttcaaag
    17641 agcaggaaga caacgtgaat cctggtactt gtcgttttta gtgacaagag ataatagttt
    17701 taaagaagtg aaaatatttc aactaggaga ttacctgcga aaaagatata aaacgatact
    17761 cgaagggttt tatcgtgagg ataaagtgct agcggttcgt agatcctata cttctcttgc
    17821 atttcagatt gtgaatcagg gtgcatgcgc atttattatt ttcatggcca tacaagccac
    17881 ctatgttggt caaattttag tggggaacct ggtgagctta attcagggga tcacgttaac
    17941 ccagtcaaca tcgcaaagca ttgtacaagg aattttaagt ctgtgtcaaa ataatttgta
    18001 tattaagcag ctatttgact ttttggatat gccggaggaa gcaaaaatac aaaagtcagt
    18061 tcaacctttg cctttgtccg ttatacacag tattgaattt cgtaatgtat cgtttaaata
    18121 tcccaacacg gaggagaatg ccatttctaa tgttagcttt actcttcatc aaggagagaa
    18181 gctggccatt gtggggagaa atggatcggg taaatcaacg attgtgaagt tactcactca
    18241 tctgtattct aatttcgaag gagaaatcag aattaatgga cactctatac acgaattgga
    18301 taaagacagc tttagaggaa agataggcgt cgtttttcag gattttgtac attatgagat
    18361 gtctgttagg gataatatag gctttggtca tgtggcttcc agagaaaatg atgaggtcat
    18421 atgggcagct attgataagg caggcattac agatttggta gctggtctgc ccgataaatt
    18481 gaacaccctg cttggaaaat ggtttgaaga tggacaacag ctatccggag ggcagtggca
    18541 gcgcatagca atagccaggg cttttatgag aaatgccgat atctatgtgt tggatgagcc
    18601 gagttctttt ttggacccac atgcggagaa ggaggttttt caaaaatttg gtcagcttgt
    18661 tcacgagaga attggagtat ttatttcaca cagattgtcc tccgcacgta tggcggatac
    18721 cattatttta atggaggagg gcagaattgt ggaagcgggc agccatgagc acttaatgga
    18781 tatggacgga gtgtatgctg aaatgttcag gctacaagct tcttcgtatc tttcacaagg
    18841 agaaagtgac cttgaggaag aaaagctgtc accttcgtta gtaagggcga caggtggatc
    18901 ataagaaaag gaaaataccc tcctatttta ggagggtatt ttctacccca tccacaaaag
    18961 tcgaactaca gccatactca caataccgac aagcacagta gccagcaaat ttttactcca
    19021 caaagcggtc accagcgtag gaaggaccgc tataagcact tgcccattaa gagtgaccga
    19081 ggtttcggtt cgtacgagca gattttccat gaccagtgcc gtgaaaatgc aaatggggat
    19141 ataggacagc cactgcaaca cgggtttggg tagcgtcagt ttttgcagca cgacaaaggg
    19201 aatgatcctt gggatggctg tgacaatcat cgcaccgata atgatatata gcacattggg
    19261 attaatattc atttgtcggt taacactcca atcgttgcgg tgatgatggt cgctacaatg
    19321 acggcgatat gtgatggcac ccaccaggat aaaaggtaca ttagaacggc catacatagc
    19381 acaagcagca ggcgatgctt gagtttggag gtctggacac tttggagctg agaaatgagt
    19441 agggccagaa acattgcagg taaggcaaag tccagaccaa aagcttccgg ctgggaaatc
    19501 caattcccga gcactccacc agccacacag gaagcaatcc aagcgagata agctgtaata
    19561 ttaagtccgt tcatccagcg gtcactgacc tgcccgcctt tagccaattt atccgatgct
    19621 accccaaagg attcatccgt taaaaggata ccgatgccta tgtttttccg cagtgaatat
    19681 ttagaaaagt aaggagccaa tgacgcactt aacagcaggt ggcgggcatt cacaataaat
    19741 gtcgttaaaa taatgacaga tggaggactg gctgcagcca gcatcgagca cataataaac
    19801 tgggaggcgc ctgcgtatac aagcgctgac atcagaccaa tttccatggt gctaacccct
    19861 gatgaagcgc ccacaatgcc tgccgcgaat ccaatacata cataaccaag cagtgtagga
    19921 atacaatctt taaccccttg taaaaagctg agtgaatcgt gctttgttcc actcaactcc
    19981 gaagctatgg acatttcaac cttaccccca gtgtataaat tttataatag tatataacgg
    20041 aagttgtaaa gtatcaatat attatacgtt tgtatgttat attgaatatt atctatagcg
    20101 aacacgtagt cttattgtac gctctcggct acactcttct aatcagaaac agtctaataa
    20161 agtagactac aggagaattg cccttgagcc cttcaaaatg gcaaacggac aaaggctgat
    20221 gattagtcaa agcagctcga atgtgttcat acaaggactg ttttgactga atggggagtt
    20281 cgtaaaaaaa gggcgcccca gtcagttcat gacttatggg acaaccctaa agtggtggct
    20341 tatataagct cctgccgttt tttcagatat ccgtagagaa taattcccga gaccgcgcag
    20401 atggctgcgc ataggccaat aactccatat cccgcctgaa gcccgcgcaa tatgccaagc
    20461 tcagtggttg cgccgtagac tatcttgacc ccttcgatta cccagccgat cacatagttg
    20521 ccaatgacac tacctatgcc catcagcgtg acgacgaacg taatagctgt atcactgtcc
    20581 ttaggatatc tccgtgcaat gaacgccatc acggtcggat agatcattgc aatgcctgca
    20641 cccgatgtgg caaagagaaa cgccagtctc tccccacccg cgattgctgc gaacgtacat
    20701 atcgctgaga aggcggagaa taaaatcgtc gaaagcacaa accccattcg gtctgtgagc
    20761 ggaccaagca acaggcgccc caacgagaag gtaagaaaga acgcggagag catgctggac
    20821 gcctttactg tactccatga atacgctttc tctaaaaagt taactagcca gcctccaact
    20881 gccagctcgg agactactcc aaacgatagg atcattacca tcatccagag tgctggatcg
    20941 cgggttaggg tcttgagtga ggtccgttcc tcatgctgca gatcgtctcc cgggaaggtg
    21001 ctgagcagtg cggccacaat cggcagcaga cagagcgaca acatagccag atacatccct
    21061 cgccagtcca gcgtatgtcc aaataccgtc aatgacatga ctcccgtcgc cagcaaaggg
    21121 gcgactgttg agctaagccc atagaaaaag tgggacaaat tcatcatcgt gccggtattt
    21181 tttacaaaaa tcctcgcccc caaaattgcg agtgcaatct ccagcatgcc gttcccgata
    21241 tacatcaaga agtaggacga ggcgaagaat ggatacgtgt gcgacagata aatgaacact
    21301 cccgagatga tcatggaagc aaaggaaata atgctgaccg ccttgattcc ccacttacgg
    21361 acaaggacgg cggtgaacga gcaggcaatc aaatacccaa gtgcgtttag agacaacaat
    21421 gttccgagct gctgttcatc cagattgaag tcgaattgaa tgcgtggaat ggcagggcct
    21481 ttaatatttt ccgagatacc aaatacaata aagccaataa aaattgtcgc cagctgcatc
    21541 gtgtacatgt ggcgggactt gcgggtttgc ggattcaaat ttagtccctc ctagatagtt
    21601 aacgttgatt ttctcacctg ttgggtgttc agggacggaa aagacatagg atagcaaccc
    21661 ctttcaagat attacaatag ttttgaaaaa cattttaata agtgaagttt aaggacattt
    21721 atattcaatg tcaatgtttt aattgacatg ttgaagtaaa cgaggaacct gaccataata
    21781 gagtaaattg tagcatgtct acttcccgtt taagctttta tatatacctt gatcggctac
    21841 acttaatcta atgtggataa taaatcgtgt attctaaatt gcaaaagata agtgatattt
    21901 tacaatacag tctatataca gcgggtactt ttgtgtattc ttcatatata gacttttgga
    21961 tatgaggagg tataattcgg tggattcaat gcaatatatt attggttcta atttggctca
    22021 aatcaggaag actagaggac ttagtttgga taaggtggct gaactgacag gggttagcaa
    22081 agggatgttg gctcaaattg agaaggggag atccaatcct acggtaacca cgctttggaa
    22141 gattgcgaac ggcttgcacg tatccttctc gacctttctt aaagaagacc cgccgcaaat
    22201 cacgaagatt cggagagcag atttgcatcc agttattgat gagggcggta actattttgt
    22261 ttaccctgtc ttcccgtatc actcggaaaa gaagttcgag gtattcacgg taagtctgaa
    22321 gccaggcttt acacacaagg cagaagagca tctgggagag gaaacgattc tcatgatccg
    22381 tggggaaatg tactttgaaa tgcaggggca acagctcaaa ctgagtgcag gggacgccgt
    22441 acaatttcaa ggatctgatt ttcataccta tcgtaatgat tcggatgagg atgccgattt
    22501 ttatgtattg atttattatg cggattagtg ggatgattaa catagtctac aacagacttc
    22561 gacacaggat tctacaaaat cctgagatat aaaaagagag caacgaggaa aagagaggaa
    22621 agaacccatg gaaagcaagt acatccgaga aacctactgc tttaagacgt cccgagtatt
    22681 tcccaatgat atcaacaatc ataacacgct cttcggaggc cgattgatgt cgtatatcga
    22741 cgatatcgca tctattgctg ccgccaagct gtgccgtacg aacacagtta cagcctctac
    22801 agattcggtg gattttttgc tgcctatcca cccgagcgat tctgtcacgc tggaagcgtt
    22861 cgtaacttgg acaggccgca gctcgatgga ggtattcgta aaagtgattc gcgaaggatt
    22921 aatgacaggc gaccgcaaaa ttgcagccac cgccttcctg acctttgtgg cattggacga
    22981 gaacaatcgt aaagtgaccg tcccacaggt gattccggaa acagaggagc aaatacaatt
    23041 acaccagaca gctccatcgc gcgcagccat acggcgtcag cggagggaag aaagcaagca
    23101 actggccagt tttctgacga cagattttcc gtgggaagtg tagtgtacta gacatcaccc
    23161 atcttacgtt tttgcgtaaa aaggagccgt ttttccgtta cgatcactaa gatctgttcg
    23221 gatgacggct ccttttggta aggatttgag ctattccact ttaactacac ggaaatgctg
    23281 attcgtcccg ccattatcgc cccattgaat ggctttggct ccatcgccag tggcgccttc
    23341 ggaaatgtcg atcagcttgc cagttgcccg atttttcagc ttgtaatagc ccccggttac
    23401 ggatacgagc tgccaatgct ggctggacca gcctccatca ttccactgtt cgatcactgc
    23461 gccgtccgct gtagcaccgc tttcaacacc aatcagcttc ccgctgttcc gattcacaat
    23521 tttatagtat ccgccgcctg catccttaag ctgccattgc tggcttggtg ctccggaatt
    23581 cgcacgctgc tctagatctg ctccgtctat cgtcgcattg ccaatgatgc ctagcggctt
    23641 gttgctcttg cgacttacca gctgataata agcatccggg tcgatgacca tcggcgtagt
    23701 tatgccctca accacaccac tggcggtatc aacgttaatg ctgtcgaacc aatccatggc
    23761 caatgaagtt gcagttggaa aacgcagtgg caaccacaca tattgcgaat cctgcacagg
    23821 accgctccac gccccagccc aacggtcgcc caaatacaga tatgaggtcg tctgcgtacc
    23881 ttcaacagga atgacgtagg ccgactgtga accgtaagtc gtcccgtccc cgaagttcat
    23941 cgtattgctc caggttcctt caatgctgga cgcagtagca tacttggcct gattgggatt
    24001 ccagccagtt gccccggatg taatcaggaa gtagacgtct ccttttttga acatcgccgg
    24061 cgcttcacga tattgtcctg gccagagtgt agttaccagc gattcaactt gaagaaaatc
    24121 cggtgttaga cgataaatgt tcagatccgc gtttacacgg gtagccgata tcaggtatgc
    24181 agtaccgtta tcgttgtata cagtcatatc acgtgaatca taatccagcg gacggaagct
    24241 gccctgatac gtataatcgc cgtctacggt atcagatgag gcaactgcca ctcgggcttc
    24301 gttgtaatta atcccgtttt ccttgtgcat ccataatacg tatttgcgtg ttttttcatt
    24361 ataaattact ttcggacgtt caatattcga tacattcagc tctacggccg agctgctggt
    24421 cagcacgttt ttacgaaact cccagttttt taaatccgag gaacgataag cggataccgc
    24481 cttgaacgtt ccattcggat tacggttttc accaaaccaa taataataac cgtccacttt
    24541 gatcattccg cccccatggg catggaccac gtttccatct gtatctttaa actgaattcc
    24601 atttactaca ttcgctgaag tagctgaagc aatcttaggt gagaacatct gaaaaatgct
    24661 taacgaaagc aaaatagtga gcataataca cagcaagcgg gcaaaatcat atttcatcgt
    24721 ttcgtcctcc tctgtatgtg ttattttaaa gcgctttcat tagtaaattc tatagaagta
    24781 gctttgaaga gctgcctatc ccaattgtat ccatattgaa ttgaaagtgc tagagtagta
    24841 tattgaccat gtatatggca agcgtcatcc aaatttgaca gacttcaatc gaatagtgag
    24901 tgtacaaacg tattatattc attaggatat acgggaggcg accatggaaa tatacgcgat
    24961 tgatacgagc aagccagagg ctgagaatca ttacgaatta ctggtaaatc gggtttcgct
    25021 ggcaaaacag cacaagttgg atcgtttttt acatcgggaa gacgctttga gggggttata
    25081 cgctgatgtg ttgttaagat ggttggcttg tcgacaatta aaaataccga atgccagcct
    25141 tcagtttaca tacaatgctt ttggcaagcc ctccttgttg aatgcgccgg catttcattt
    25201 taatgtttcc cattcgggaa aatgggtagt atgcgctatc gatgatcatc cgcttggtat
    25261 tgacattgaa cagctccgtc ctattgattt tgaagtaggc agggtgtgct tctcggacac
    25321 agagtatgat gcattaatgc atcaggatgc agagagtcgt ttatcctatt tttacgatct
    25381 ttggacgctt aaggaaagtt ttgtgaaggc cgaaggacag gggctaacgc ttccgttaaa
    25441 gtctttttca ttcgagttgg aaacacaacc gtctataggt ttcacgacag agggctttac
    25501 tacggtgtat tgtcatttta agcagtatga gctagaccca gattataaaa tggctgtctg
    25561 tgcagctcat gatgactttg cacaggtggt acagcaggta gatataaata cactacgttt
    25621 ggaagtagca accctggcgt aatatgcagc agatcaagcg tatagttgga aaaaaggaga
    25681 tgagtggcgt tgacattcgt tttgttcaag cacggcaggt tatatgggga ctgggctacc
    25741 aaaggagact ccatcgttgt acagcatggc cgcatacagg ccattggaaa tgctcgggag
    25801 cttgaattgc agttatctgg taaggagtat gaaaccgtgg attgggaggg agcccatgta
    25861 ctgccgggct taaccgatgc ccatatgcat ttgtctatgc atggtatgaa gctagctatg
    25921 ctggatttaa catcagctac ttccaagaac gagatgctgg ctatgctgcg caagcgggtc
    25981 gctgtaacac cgccgggaga gtggatttta ggtcttaatt ggaacgaaaa tgcatttaat
    26041 cctgttgaaa ttccgaatat agctgagcta gatgctatta cagatcagca cccggtatat
    26101 ctgacccgta cgtgttttca tacgttttta gctaattcag aggcatttcg gcgtgcaggt
    26161 attaatgaga acacccctga tccggcttca ggagcctatg gacgggacgc agagggtcga
    26221 ttaaatggat taatttatga ggaagcatcc tttgccttta caagcgtgca gccagagccg
    26281 gattattcgg tgaagaagga tacgatccgg cgagcttgtc tggatgcgct acggctgggg
    26341 ctgactgctg cgcatacgga ggatttacgt tttttgggca gcgtggagac aatgcagcga
    26401 atttacagag agctgagaga agaaggtctt gcatttcgca cacaccagct catctatcat
    26461 ccatttatgg aagaagtgaa agtacaggag ctgcgtgcag gtaccggaaa tgagtggttc
    26521 aaaatcggtg cgattaaaat gtttgctgat ggcgctattg gtggaagaac ggctttatta
    26581 tccgaacctt atagtgatgc tccacatacg tgtggaatgg ccatccaacc acagccagag
    26641 ctaaatcaga tggtggcagc agccagagcc gcaggctttc cagtggctgt acatgccatc
    26701 ggagatgaag cggcgcatat gattttgaca gcgatggagg ctcatggatt aacggaggaa
    26761 agcgggttgc cggatcgtct gattcatggg caggtgctaa gggctgattt ggtcaaaaga
    26821 atggcgaagc tgccgctgat tgcggacatc cagcctcgtt ttgtcgccag tgactttccc
    26881 tgggtgctgg atcgagttgg gaaagaacgg agcgaatatt tgtatgcctg gaaaaagctg
    26941 ctgcaagtag gtattccgtg tgctggaggc agtgatgcgc cgatcgagcc gctaaaccca
    27001 tttctgggta tacatg
//
