LOCUS       NZ_GL985606            21158 bp    DNA     linear   CON 21-JUL-2024
DEFINITION  Actinomyces sp. oral taxon 448 str. F0400 SCAFFOLD1, whole genome
            shotgun sequence.
ACCESSION   NZ_GL985606
VERSION     NZ_GL985606.1
KEYWORDS    WGS; STANDARD_DRAFT; RefSeq.
SOURCE      Actinomyces sp. oral taxon 448 str. F0400
  ORGANISM  Actinomyces sp. oral taxon 448 str. F0400
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 2812018)
  AUTHORS   Muzny,D., Qin,X., Deng,J., Jiang,H., Liu,Y., Qu,J., Song,X.-Z.,
            Zhang,L., Thornton,R., Coyle,M., Francisco,L., Jackson,L.,
            Javaid,M., Korchina,V., Kovar,C., Mata,R., Mathew,T., Ngo,R.,
            Nguyen,L., Nguyen,N., Okwuonu,G., Ongeri,F., Pham,C., Simmons,D.,
            Wilczek-Boney,K., Hale,W., Jakkamsetti,A., Pham,P., Ruth,R., San
            Lucas,F., Warren,J., Zhang,J., Zhao,Z., Zhou,C., Zhu,D., Lee,S.,
            Bess,C., Blankenburg,K., Forbes,L., Fu,Q., Gubbala,S., Hirani,K.,
            Jayaseelan,J.C., Lara,F., Munidasa,M., Palculict,T., Patil,S.,
            Pu,L.-L., Saada,N., Tang,L., Weissenberger,G., Zhu,Y., Hemphill,L.,
            Shang,Y., Youmans,B., Ayvaz,T., Ross,M., Santibanez,J., Aqrawi,P.,
            Gross,S., Joshi,V., Fowler,G., Nazareth,L., Reid,J., Worley,K.,
            Petrosino,J., Highlander,S. and Gibbs,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2011) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Standard Draft
            Current Finishing Status          :: Standard Draft
            Assembly Method :: Newbler Assembler v. 2.3-04192010
            Genome Coverage                   :: 32.58x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220835.1-RS_2024_07_21
            Annotation Date                   :: 07/21/2024 00:51:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,460
            CDSs (total)                      :: 2,404
            Genes (coding)                    :: 2,339
            CDSs (with protein)               :: 2,339
            Genes (RNA)                       :: 56
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 20 of 65
            Pseudo Genes (incomplete)         :: 50 of 65
            Pseudo Genes (internal stop)      :: 5 of 65
            Pseudo Genes (multiple problems)  :: 9 of 65
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:02:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2042472
            Orig. end                         :: 2063630
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GL985606.1.
            Actinomyces sp. oral taxon 448 strain F0400
            Strain source, body site: Oral
            Inquiries should be directed to microbe@hgsc.bcm.tmc.edu
            This is a reference genome for the Human Microbiome Project. This
            project is co-owned with the Human Microbiome Project DACC. This
            sequence is generated as a part of the Human Microbiome Project
            (HMP), funded by the National Institutes of Health (NIH), National
            Human Genome Research Institute (NHGRI) Large-Scale Sequencing
            Research Network and the National Institute of Allergy and
            Infectious Diseases (NIAID) Microbial Genome Sequencing Centers
            Program. The mission of the HMP is to generate resources to enable
            the characterization of the human microbiota, the microbial
            communities living within human bodies, and analyze the role of
            these organisms in human health and disease. See
            http://www.hmpdacc.org/ for more information.
            The sequenced strain was obtained from Dr. Jacques Izard (contact
            information: Forsyth Institute, Department of Molecular Genetics,
            140 The Fenway, Boston, MA, 02135). The genomic DNA was prepared
            from a single bacterial isolate. The sequence generated included at
            least 10 fold coverage of Roche/454 Lifesciences FLX fragment data
            and at least 8 fold clone coverage of Roche/454 Lifesciences
            paired-end data. The Roche/454 Lifesciences sequence was assembled
            using the Roche/454 Lifescience Newbler assembler. This draft
            assembly meets the HMP draft quality standards (more than 90% of
            the genome is included in contigs, more than 90% of a core set of
            bacterial genes are found with > 30% identity and > 30% length;
            more than 90% of the bases in the assembly have more than 5 fold
            sequence coverage, the contig N50 length is greater than 5kb, the
            scaffold N50 length is greater than 20kb, and there is less than 1
            gap per 5kb).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21158
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="4"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21158
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21158
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11158](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11158
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(<76..168)
                     /locus_tag="HMPREF9062_RS13850"
                     /pseudo=""
     CDS             complement(<76..168)
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012723073.1"
                     /locus_tag="HMPREF9062_RS13850"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD(P)-binding domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MMKIGFIGLGVMGKPMAINLLEAAHELYLDE"
     misc_feature    complement(150..164)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            complement(354..476)
                     /locus_tag="HMPREF9062_RS13780"
                     /old_locus_tag="HMPREF9062_1839"
     CDS             complement(354..476)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF9062_RS13780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF9062_1839"
                     /product="hypothetical protein"
                     /protein_id="WP_009749737.1"
                     /transl_table=11
                     /translation="MGPALVGRSGVADLYGASIGHTLAISLIIAVPAGILVAMI"
     gene            complement(556..1614)
                     /locus_tag="HMPREF9062_RS08685"
                     /old_locus_tag="HMPREF9062_1840"
     CDS             complement(556..1614)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009233856.1"
                     /locus_tag="HMPREF9062_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1840"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_034254058.1"
                     /transl_table=11
                     /translation="MAPVYGSSRRAGSTGPWSMLRPGPRSALPHGLSWTPLSPLDNQAL
                     AELIARAESADDPPYRTTAEETAEYFVDPTYSGVAGRDDTGVMRAFALVRLRPAGEIYT
                     SMIGVVDPDFRRRGIGRALLHWQTERARHLIGSERAGAAPGSAAATAPAHVVTTVLEDD
                     ERMKAHLGELGFEPRRWYREVRRPLVEEIPEVDIDGFLTIEPWSEELDEVVRIAHNQIF
                     DGEYGASQMTREDWKAGRTYFAPSWSFVAVDHSGDRARVAGYLRSGRYEQDWAALGWRE
                     GYTDMLGVLAEYRSRDVAPALLTAAMRAYRRDGMDYAAAGVDSDNPAGAVDLYRELGYT
                     PTQGTVLYALDV"
     gene            complement(1744..4005)
                     /locus_tag="HMPREF9062_RS08690"
                     /old_locus_tag="HMPREF9062_1841"
     CDS             complement(1744..4005)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178460.1"
                     /locus_tag="HMPREF9062_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1841"
                     /product="type IIA DNA topoisomerase subunit B"
                     /protein_id="WP_009749739.1"
                     /transl_table=11
                     /translation="MPREEATTSPRDYSARHLSVLEGLEAVRKRPGMYIGSTDQRGLMH
                     CVWEIVDNGVDEALEGYGDRIDVTVHDDGSVEVRDTGRGVPVDVEPSSGLTGVELVYTK
                     LHAGGKFGGGSYGAAGGLHGVGASVVNALSARMDVEVDRGGKTYAMSFRRGVPGVFTDP
                     STGPDLASPFTEYTHQTPELRVIGKVCRGVTGTRVRYWADPQIFPSPTEYDAAALRARL
                     RQTSFLIPGLTLTLTDERSAEETARAERMPSSGSKATDDLALRAAAKNATRTAEGLLDA
                     SPATEIGEADTAVFRAEGGTADFVDFLATDGSVTDTFRLTGQGVYTETVQQLDRRSGHL
                     RPVEVERTCDVDIALRWGIGYDTIERSFVNIIATPMGGTHLTGFEQAVVKVLRKQIGTN
                     ARALKVTSRDGRIEKDDILAGLTAVVTVRVPEPQFEGQTKEVLGTAPVRQIVAKVVTEE
                     LTALLTSSKRDLKAQSRALQEKIVGEMRARVSARMHKEITRRKTALETSTLPAKLADCR
                     SDDVTASELFIVEGDSALGTAKNARNSEFQALLPIRGKILNVQKASQADMLHNAECSAI
                     IQVVGAGSGRTFDLKTARYGKVILMTDADVDGAHIRTLLLTLFFRYMRPMIEAGRVYAA
                     VPPLHRTEVPARGRRKKEIIYTYSDDELVRTLRRLEKQGRAFKEPQRYKGLGEMDAHQL
                     AETTMEPEHRTLRRITLGDEAELVEAESVFELLMGSSVEPRRGFIIAGARDVDRERIDA
                     "
     misc_feature    4029..4044
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    complement(4030..4043)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 22.38"
                     /tool="antismash"
     misc_feature    complement(4355..4364)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    4392..4405
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.29"
                     /tool="antismash"
     misc_feature    complement(4394..4407)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.25"
                     /tool="antismash"
     misc_feature    4398..4411
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.16"
                     /tool="antismash"
     misc_feature    complement(4398..4413)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.26"
                     /tool="antismash"
     misc_feature    4442..4458
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.87"
                     /tool="antismash"
     gene            complement(4453..5232)
                     /locus_tag="HMPREF9062_RS08695"
                     /old_locus_tag="HMPREF9062_1842"
     CDS             complement(4453..5232)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009404727.1"
                     /locus_tag="HMPREF9062_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1842"
                     /product="hypothetical protein"
                     /protein_id="WP_009749740.1"
                     /transl_table=11
                     /translation="MSVQEFRDHEIARLERSGWAANAPLREALDVAGLRPPAQVVAECL
                     DETADSGAAGAGGGGGSTGGRWERAECAVTRLREHFASFRFAGDVDYGLLAVPDAARFD
                     TRGAVDPRIRCGQRPDLVEDLVDPALGKGADLSGLTLGRDGWMVVAGVVGQYGVSAGSY
                     EDIIKAPVERFEVDGVDARAFMTRQVWGARLLQCPPGVVPDSDDAERWTFTIFPAEGLV
                     DGRAVSGTVLKKRVRFRLGKANRGIGSARVSPALPLM"
     misc_feature    complement(5415..5428)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.99"
                     /tool="antismash"
     gene            5440..5703
                     /locus_tag="HMPREF9062_RS08700"
                     /old_locus_tag="HMPREF9062_1843"
     CDS             5440..5703
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565039.1"
                     /locus_tag="HMPREF9062_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1843"
                     /product="hypothetical protein"
                     /protein_id="WP_009749741.1"
                     /transl_table=11
                     /translation="MNTTGTPVTAPVTAPIPTPTPAASPPDARELTTADRCDACGAQAF
                     IRVVLASGELLFCGHHGRRNMTSLEKQALFIQDETSRLTADG"
     misc_feature    complement(5441..5455)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.44"
                     /tool="antismash"
     gene            complement(5807..6616)
                     /gene="thiD"
                     /locus_tag="HMPREF9062_RS08705"
                     /old_locus_tag="HMPREF9062_1844"
     CDS             complement(5807..6616)
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178456.1"
                     /locus_tag="HMPREF9062_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1844"
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="WP_009749742.1"
                     /transl_table=11
                     /translation="MTVTALTVAGSDPSGGAGIQADLKTMSALGAYGMSAVTALTAQST
                     RGVTGVHTVPVDFVRLQLDTLLEDIVPDATKVGMLATAGLAEAVSGYLPRLTCTVLDPV
                     MVATSGDRLLDEDAISAVRRLCTLVDLITPNLHEAAVLLDEEPAKDVRALHAQAQRLLD
                     AGARRVLVKGGHLDAEATDVYADSDGVTLLRGRRVRTRNTHGTGCTLSSAIASLRPRRA
                     AWLQTVRDAKAYLTDALEHADSLGVGHGHGPVHHFHALWREVDGAHE"
     gene            complement(6613..7275)
                     /gene="thiE"
                     /locus_tag="HMPREF9062_RS08710"
                     /old_locus_tag="HMPREF9062_1845"
     CDS             complement(6613..7275)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565045.1"
                     /locus_tag="HMPREF9062_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1845"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_009749743.1"
                     /transl_table=11
                     /translation="MRPAPDLSVYLVTDADQCRSRGRSVLRTAEEAVAGGVTCVQLRAK
                     RADGGAFLDEVLAVAGAIGGRVPVIVNDRIDVFLAARRLSAAVAGVHVGQADLPAVLVR
                     RLIGDDAFLGLSAATPDELRLADEQGACDHVGIGTIRDTPTKPDAPAGLGLDGAARLAA
                     LTDLPAVAIGGVTVADAPALRAGGLNGIAVVSAICAAEDPRAAAAALHSAWNEGESR"
     gene            complement(7272..8087)
                     /gene="thiM"
                     /locus_tag="HMPREF9062_RS08715"
                     /old_locus_tag="HMPREF9062_1846"
     CDS             complement(7272..8087)
                     /EC_number="2.7.1.50"
                     /GO_function="GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005962561.1"
                     /locus_tag="HMPREF9062_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1846"
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="WP_009749744.1"
                     /transl_table=11
                     /translation="MRRCARAHSVLLAVRETTPLISCITNSVAAGFTADVLLASGAAPA
                     MVDITGEAGTFAAAASGLLINLGTPQPEQRAAAREAAAAAGEAGTPWVLDPVAVGSLVH
                     RTALARDLLSMEPVVVRGNASEIMALAGTGGGGRGPETADDVDSALGAARAMSERHGFV
                     AAVSGPVDAIVDGQRMTRITGGSPMLTRVTGGGCALGALIAAFIAAGREQDVDARAATV
                     ACHEVYSAAAQRAAARSTGPGSFRPAFLDALYDLGAEDLEAVAVSEEQA"
     regulatory      complement(8077..8166)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(8238..9833)
                     /locus_tag="HMPREF9062_RS08720"
                     /old_locus_tag="HMPREF9062_1847"
     CDS             complement(8238..9833)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008733797.1"
                     /locus_tag="HMPREF9062_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1847"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_009749745.1"
                     /transl_table=11
                     /translation="MASSTATRKRTQRADDVDKALEDEVVLDESGDSGDSAPADPDGEN
                     AEAAQSEQEESEEPVPELRDYYLDVSLEANGDGSKRKPFNTPAALKGVRLAPGATLYVR
                     SRTTVEGLELTGDGTLEEPITLAPYGHGPVPRFVIPEEEDPVVAREFLTSNGFIFRGWV
                     IKGIKMSPSIAALTGELDRIRREQAEKAAAKRSGRKSRERNKDGSFTVSDSDEADEPAQ
                     KVVTAGATADPVKDYLKQIGKVALLNAAQEVELAKRIEAGLYAEHLLATEGNNLEAKYR
                     RELHWVAQDGQRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDY
                     TKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTP
                     EELAVELDMTPEKVVEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTL
                     LQEQLHAVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKL
                     RHPSRSQVLRDYLD"
     gene            10001..11158
                     /locus_tag="HMPREF9062_RS08725"
                     /old_locus_tag="HMPREF9062_1849"
     CDS             10001..11158
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009747443.1"
                     /locus_tag="HMPREF9062_RS08725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1849"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_034254066.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5e-40, bitscore:
                     134.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSALSPTLQAVRTAVEARLARALDAHRARCTGEAPAADELFDAAA
                     DLMSSGKRMRALLGAVGLALGEPGAAPEQRSRLMTGAASASLGSALELYQASALVHDDV
                     IDASATRRGRPTAHRRWAAQHVSSGWRGDAAAYGEGAAILLGDLLLSLAGIEIGRAVRP
                     LADGARAGAVRDAFDVMTAEVAVGQFLDVRGEMVLPPSPDDDPIASGRVMLTSALTVVR
                     RKSARYSVMHPLVIGALLGGVTSADPLHKALEIFGEEIGIAFQLRDDVLGVYGDPDLTG
                     KPAGDDLREGKRTALMAMAWQRADRPGRLLLSRVLTDRDASSELIAAAADLIRDCGALE
                     AHEKTIAAHARAGVRALDDVPSGALDDAGRADLSSLARALTSRSS"
     gene            11231..13276
                     /gene="pknB"
                     /locus_tag="HMPREF9062_RS08730"
                     /old_locus_tag="HMPREF9062_1850"
     CDS             11231..13276
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006549603.1"
                     /locus_tag="HMPREF9062_RS08730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1850"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_009749748.1"
                     /sec_met_domain="Pkinase (E-value: 5.2e-47, bitscore:
                     157.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKDPLIGRLVDSRYEIVDRVARGGMATVYRAHDRRLDRVVGLKL
                     MHAHLADSPDFVARFRREARAAARLSNPGVVAVYDQGSLDGVAYLVMEYVEGPNLRDLI
                     AAGPLSIREALGLTAQILRPLGAAHRAGLVHRDIKPENVLLPADGSVAKVADFGLARAV
                     TEVTQTTTGNVLGTVAYLAPELITSGSSSPRADVFSVGVITYELLTGEQPFTADSPIQI
                     AFRNVHEDIPLPSTTVPDLPGGVDGLVSAMTRRDPEQRPQDADETLTRLREAVADLSES
                     ELAVKRGGGPGSVRTQEVLAANAEIARTAMGAQSPDETVDEEDSQTTPGAGLRTVSLPI
                     GSIGPQAQGGGDGRTRQLAREEFMRADDQDTAAVPHNDQRRTLRRRAVLGAAATALLTV
                     TGTGIGAWYAFKGPGRSVPVPEIVGQTAEDAQKSVETAGLTWAAPNREYSDTIPAGSVV
                     SCEPGPGDGARPGQAVTAVVSRGVEQKKVPDVVGEAQDEAVKAITDAGLSPGAITQDYS
                     TSVASGLVVSTDPAAGQSVNHSSAVAIVVSKGRQPATVPDVAGMNIEQATTTLEAAGLR
                     LGAQTRVFSDSVTADLVVSTDPAAGDTSVHHGDAIGVEVSKGPETVTVPDVKGMKEDEA
                     TRALKDVGLEATVSTSWGGLLGKVRSTDPVAGTNVAKGSTVTLHII"
     misc_feature    11378..11380
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11771..11773
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13390..14730)
                     /locus_tag="HMPREF9062_RS08735"
                     /old_locus_tag="HMPREF9062_1851"
     CDS             complement(13390..14730)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565051.1"
                     /locus_tag="HMPREF9062_RS08735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1851"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_009749749.1"
                     /transl_table=11
                     /translation="MNELNAPRTAAGWRDCPASQQPAYPDADALKAVSDDLRSRPPLVF
                     AGEVDALSTQMAAAGRGRAFVLMGGDCAESFADNTADNIRLKLQTILQMAAVLTYGAST
                     PVVKIGRIAGQYAKPRSADTETRDGVTLPSYRGDSVNDHAFTLAARVPDPARMLNAYLR
                     AGTTLNLIRSFTMGGYADLREVHSWNRGFTANPAYARFESFAEEIDRAMRFMEAAGVDF
                     DALRQVDFYAAHEALLLEYEDAMIREDSRSGRLYDTSAHFLWVGERTRGAEHAHVALLR
                     GVRNPVGVKVGPTTAPAELVALIDRLNPHGDAGRLTLITRMGADRIREALPALIEAVRA
                     DGRPVTWVTDPMHGNTITSDNGYKTRRFDTVMDEVRGFFEVHRALGTVPGGIHVELTGD
                     DVTEVLGGGEHIEEATLGERYETLVDPRLNHQQSLEMAFEVAEMLRG"
     gene            complement(14837..16066)
                     /locus_tag="HMPREF9062_RS08740"
                     /old_locus_tag="HMPREF9062_1852"
     CDS             complement(14837..16066)
                     /EC_number="2.7.1.90"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565052.1"
                     /locus_tag="HMPREF9062_RS08740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1852"
                     /product="pyrophosphate--fructose-6-phosphate
                     1-phosphotransferase"
                     /protein_id="WP_009749750.1"
                     /transl_table=11
                     /translation="MSIRRVALLTAGGFAPCLSAAVGDLIERYTEVAPGVEIIAYQYGY
                     HGLLTGNYIVVDAQGRKDAGVLREYGGSPIGNSRVKLTNAKNLVERGLVAEGIDPLEFA
                     AEQLRKDGVDVLHTIGGDDTNTTAADLAAYLHEHDYELTVVGLPKTIDNDIVPIRQSLG
                     AWSAAEEGAGFAFNVIGEHRSNPRMLIIHECMGRNCGYLTAETARRYHELLKSRKWAPS
                     LGLTRERWDVHAVFLPEMKLDLAAEAKRLKALMDEQGNVNIFLSEGAGVPEIIAEKEAR
                     GEEVERDPFGHVKLDTINPGQWFAGQFAGLIGAEKVMVQKSGYYSRATNAKAEDLNLIK
                     SMCDVAVDCAQRGESGVIGQDEENDDVLGAIAFPRIAGGKPFDISRPWFTSLMGDLGQI
                     VEPAEAASGH"
     gene            complement(16258..17136)
                     /locus_tag="HMPREF9062_RS08745"
                     /old_locus_tag="HMPREF9062_1853"
     CDS             complement(16258..17136)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005985404.1"
                     /locus_tag="HMPREF9062_RS08745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1853"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_009749751.1"
                     /transl_table=11
                     /translation="MGYRGIKTAVGPALEMLYQPWIRGEESIPIEGAAILASNHLAVID
                     SFFLPLLVDREVAFIGKSDYFTGRGLKGWAVKNFMTAVGTIPVDRSGGRASQAALQAGI
                     DRVRSGELFGIYPEGTRSPDGRLYRGKTGVARIALATGAPVIPVAMIGSDLAQPIGQAI
                     PSTRHRVGIVVGEPLDFSRYKGLENDRFVLRSITDEIMYSLMALSGQEYVDLYAADVKK
                     AMDAEKMSADEVVSEMLRAQALKRPAAAPVSAPGGRPAPDVEVPEPPDETEGGASHASD
                     DEPRDPTEGRQ"
     gene            17366..19018
                     /locus_tag="HMPREF9062_RS08750"
                     /old_locus_tag="HMPREF9062_1854"
     CDS             17366..19018
                     /GO_function="GO:0003724 - RNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000027 - ribosomal large subunit assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178445.1"
                     /locus_tag="HMPREF9062_RS08750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1854"
                     /product="DEDD exonuclease domain-containing protein"
                     /protein_id="WP_034254900.1"
                     /transl_table=11
                     /translation="MQASFEDMGTPLREVAFVVVDLETTGGAAGAHAITEIGAVRVRGG
                     TVEEEFSTLVDPGRAIPAQITVLTGITNAMVAGAPSVGEALVSFLEWARWSEADTVLVA
                     HNARFDVGHLRRASRELALPWREPTVLDTLALARRTWGRSDVPNHRLGTLASFVGSPTR
                     PTHRALDDARATVDVLHAALQVLAPQGVTHLEDLATATDPVPARRRIKSRMADGLPTGP
                     GVYRFLSRTEQVLYVGSAVNLRRRVRSYFTAAEKRPTIARMLETAVGVRVIETATEIEA
                     RVRELRLIAELNPPANRRSRTPQHRPWVRLADAPEPHLVTTTALASDDVLSAVGPFPSR
                     SAAREAIRAAESVLRLRAWDGRALKSPIAGGTSADTGTAMRALSGEVDLVAVPVLRRVE
                     ELAARERYEEAGAWTARLRSLLLGASRAERVRPLLTCPHLIAARRRDGGGWELVAVRWG
                     RLAGSMTTPAGADPRPAVDALRATAQVVERPQRVGMGAGVDETLLLADWVLDAGARLVE
                     VADCGNEDGSGCAVLSWPIGAAARHRRVLDSGP"
     gene            complement(19183..19626)
                     /locus_tag="HMPREF9062_RS08755"
                     /old_locus_tag="HMPREF9062_1855"
     CDS             complement(19183..19626)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565060.1"
                     /locus_tag="HMPREF9062_RS08755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1855"
                     /product="hypothetical protein"
                     /protein_id="WP_034254069.1"
                     /transl_table=11
                     /translation="MTDQAATDRLELLVFSDDASVRQEVIEGVGRRPARGLPLVSWTRA
                     ATAEGVRLAIRDRAKEGKAPFDVLVLDAETKKFGGMGLAHELFTELDSRPPVVLLTARP
                     QDDWLAAWSKAEAVVPRPLDPMALQEGVTKAFRARRGAVVPAG"
     gene            19808..20431
                     /locus_tag="HMPREF9062_RS08760"
                     /old_locus_tag="HMPREF9062_1856"
     CDS             19808..20431
                     /EC_number="1.15.1.1"
                     /GO_function="GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006549597.1"
                     /locus_tag="HMPREF9062_RS08760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_1856"
                     /product="superoxide dismutase"
                     /protein_id="WP_009749754.1"
                     /transl_table=11
                     /translation="MALYTLPELPYDYAALEPHISGRIMELHHDKHHAAYVAGANTALD
                     KLRAARAADDFAAVNLWEKNLAFNLGGHINHSIFWKNLSPNGGGEPEGELAEAIRDSFG
                     SFEAFKKHFTATALGIQGSGWAVLAYDSVAGGLVIFQLFDQQGNVPVGTIPLFQVDMWE
                     HAFYLDYLNVKADYVKAIWNIVNWQDVSERLAAAVARTESLIVR"
ORIGIN
        1 tttggaatcg aaggtccagc cggggatgag gaaccgcatg ccgatcgaat cgtcgcgggc
       61 cccgacgctc cggacctcgt ccaggtaaag ctcatgggcc gcctcgagca ggttgatggc
      121 catgggcttt cccatgactc cgaggccgat gaatccgatc ttcatgatat tccttctgtt
      181 cggtgcgcgg ggtgccgaat acgatatgaa tggcgcgggt ggtgggaaga cggcggggag
      241 gagcgacggc cagtgagatg cccatgccgg gaagctcgtc ctcgctgaac tcgcattcgg
      301 agaccagacc cgcggggatc tcgggggttg cagtccacga agcccaggcg gggtcagatc
      361 atcgcgacaa gaatgccagc ggggactgcg atgatcaggc tgatggccag ggtgtggccg
      421 atcgaggcgc cgtacaggtc ggcgacgccg gagcggccga ccaaggccgg gcccacaggg
      481 gctcgacctg cagacggtcg tcaacgggcc ggccccggta gtggcgctgc gtacgggcct
      541 ccgggctagg gcgcctcata catccaaagc gtagagaacc gtgccctgag tgggcgtgta
      601 gcccagctcc cggtacaggt cgacagcgcc ggcggggttg tccgagtcga cacccgcagc
      661 cgcgtagtcc atgccgtccc ggcgataggc gcgcatagca gccgtcagca gcgccggagc
      721 cacgtcccgg gaccggtatt cggcgagaac ccccagcatg tccgtgtatc cctcgcgcca
      781 ccccagagca gcccagtcct gctcatagcg gcccgaacgc agatatcccg ccacacgagc
      841 ccggtccccc gagtgatcca cggccacgaa gctccatgac ggggcgaagt aggtcctgcc
      901 cgccttccag tcctcgcgcg tcatctggct ggccccgtac tcgccgtcga agatctggtt
      961 gtgcgcaatg cggacgacct catccagctc ctcgctccac ggctcgatgg tgaggaaccc
     1021 atcgatgtcc acctccggta tctcctcgac cagagggcgg cggacctccc ggtaccaccg
     1081 acggggctcg aagccgagct cgccgaggtg cgccttcatg cgctcgtcgt cctccaggac
     1141 agtggtgacc acgtgggcgg gggcggtggc ggcggccgat ccgggcgccg cacccgcgcg
     1201 ctcggagccg atgaggtggc gggcgcgctc ggtctgccag tgcaggagcg ccctgccgat
     1261 gccccgcctg cggaaatcgg ggtcgactac cccgatcatc gaggtgtaga tctctccggc
     1321 gggccgcaac cgcaccaggg cgaaggcgcg catgacgccc gtgtcgtcgc gtccggccac
     1381 cccggagtag gtcgggtcga cgaagtattc ggccgtctcc tccgcggtgg tccggtaggg
     1441 cgggtcgtcg gctgattcgg cgcgggcgat gagctcggcc agcgcctggt tgtccagggg
     1501 gctcaggggc gtccaggaca ggccgtgcgg cagagccgag cgtggcccgg ggcgcagcat
     1561 cgaccagggg ccggtggaac cggctcgacg cgaggagccg tagacggggg ccatgagcac
     1621 ctccttgcag ggacccgtga agggcccagt agaacagcgg tggatctgcc ggcactttac
     1681 cggacaccga gatgactcat agagaactca cgagaggatt cacctactcc gatacgcctt
     1741 ctctcaggcg tcgatgcgtt cacgatcgac atcgcgggcg ccggcgatga tgaagccccg
     1801 acggggctcg acactcgagc ccatgaggag ctcgaagacg ctctccgcct ccaccagctc
     1861 ggcctcgtcc cccagggtga tgcgtcgcag ggtgcgatgc tcgggctcca tggtggtctc
     1921 ggcgagctga tgcgcgtcca tctcccccag gcccttgtac cgctggggct ctttgaaggc
     1981 gcgtccctgc ttctccagcc tgcgcagggt gcgcaccagt tcgtcgtcgg aataggtgta
     2041 gatgatctcc ttcttgcgcc gcccccgggc gggcacctcg gtgcgatgca gcggcgggac
     2101 cgcggcgtag acgcggcccg cctcgatcat ggggcgcatg taacggaaga agagggtgag
     2161 caggagagta cggatgtggg cgccgtcgac gtcggcgtcg gtcatgagga tgactttgcc
     2221 gtagcgggcg gttttcagat cgaaggtgcg cccggacccg gcccccacga cctggatgat
     2281 ggccgagcac tcggcattgt gcagcatgtc cgcctgcgag gccttctgaa cgttgagaat
     2341 cttgccgcgg atgggcagca gcgcctggaa ctcggagttg cgggcgttct tggcggttcc
     2401 cagggccgag tcgccctcga cgatgaacag ttcggaggcg gtcacgtcgt cggaccggca
     2461 atcggccagc ttggccggca gggtcgaggt ctccagggcc gtcttgcgac gggtgatctc
     2521 cttgtgcatg cgggcggaca cgcgcgcgcg catctcaccg acgatcttct cctgcagagc
     2581 gcgggactgg gccttgaggt cccgcttgga ggaggtcagc agggcggtga gctcctcggt
     2641 gacgactttg gcgacgatct gccgtacggg ggcggtgccg aggacctcct tggtctggcc
     2701 ttcgaactgg ggctcgggca cgcgcacggt gacgaccgcg gtcaggccgg ccaggatgtc
     2761 gtccttctca atgcgcccgt cacggctggt gaccttcaga gcgcgtgcgt tcgtcccgat
     2821 ctgcttgcgc agaaccttga cgacggcctg ctcgaagcct gtcaggtgcg tgccccccat
     2881 gggagtggcg atgatgttga cgaaggagcg ctcgatcgtg tcgtagccga taccccagcg
     2941 cagggcgatg tcgacgtcgc aggtacgctc gacctcgacg gggcgcaggt gtccgctgcg
     3001 ccgatcgagt tgctggaccg tctcggtgta cacgccctgg ccggtcagac ggaaggtgtc
     3061 ggtcaccgag ccgtcggtgg ccaggaaatc gacgaaatcc gcggttccgc cctcggcgcg
     3121 gaacaccgcg gtgtccgcct ccccgatctc ggtcgccggg gatgcatcga gcagcccctc
     3181 cgcagtccga gtggcgttct tcgccgcagc tcgcagcgcc aggtcgtcgg tggccttcga
     3241 gcccgacgac ggcatgcgct cggccctggc ggtctcctcg gcgctgcgct catcggtcag
     3301 ggtcagggtc aggccgggga tcaggaaact ggtctggcgc aagcgggcgc gcagcgcggc
     3361 ggcgtcgtac tcggtcgggg aggggaagat ctgagggtcg gcccagtagc gcacgcgcgt
     3421 gcccgtcacg ccccggcaga ccttgccgat cacgcgcagt tcgggggttt gatgcgtgta
     3481 ctcggtgaat ggagaggcga ggtccggacc ggtggacggg tcggtgaaga cgccaggcac
     3541 gccgcggcgg aagctcatgg cgtaggtctt cccgccccgg tcgacctcga catccatgcg
     3601 ggcgctcaga gcgttgacga cgctggcgcc cacgccgtgc agaccaccgg cggcgccgta
     3661 ggagccgccg ccgaacttcc cgccggcatg gagcttggtg tagacgagct cgactccggt
     3721 cagacccgag gagggttcga catccacggg caccccgcgg ccggtgtcgc gcacctcgac
     3781 ggagccgtcg tcgtgaacgg tgacgtcgat acgatccccg tagccctcca gcgcttcgtc
     3841 gacgccgttg tcgacgatct cccacacgca gtgcatgagg ccccgctgat cggtggagcc
     3901 gatgtacatg ccgggacgct tgcgcaccgc ctcgagcccc tccaggacgg agaggtgacg
     3961 ggctgagtag tcgcgggggg aggtcgtcgc ttcttctcgg ggcacggagg caatctagcg
     4021 gacggatctc gaacgtgtgt tctcccgcgc cacggtgtga ccatcacccg cccgagcgcc
     4081 cgggccgccg ctccgagacc agcccctcgc agccgcccga gttccgctgc tcgtcgcctc
     4141 gaacgcatgc caccgccgaa ttttcgcagt gactccgcag gcggtagccg caccagatcg
     4201 gttcgcgcac aaggcggcgg cagcggccca gccggcggga cccgacctcg ctgtgccgaa
     4261 cgttgcaagg tccgcgcttg ggacggcgcg gctgtcaacg ctcggtcatg gcgccgaccc
     4321 gactctcgct cgtaccgcgt tatcgctgcc cctgtcaaaa tatatgagaa ctaaattcgc
     4381 ctctgtactt ctatagtaag aattatggtc aatacatgtc gttccgcatc gcaaatctcg
     4441 accgtttcaa aatcacatga gaggcagtgc cgggctcacg cgggcactgc cgatcccgcg
     4501 gttcgccttg cccagccgga aacgcacccg tttcttgagc accgtaccgg agacggcccg
     4561 gccatccacc aggccctcgg ctgggaaaat ggtgaaggtc caccgctcgg catcgtcgga
     4621 gtcgggaacg acgccgggcg ggcactgcag caggcgggcg ccccagacct ggcgggtcat
     4681 gaaagcacgg gcgtcgacgc cgtcgacctc gaagcgctcg acgggggctt tgatgatgtc
     4741 ctcatagctc cccgccgaga ccccgtactg tccgacgaca ccagccacca ccatccaacc
     4801 gtcccgtccc agcgtgagtc cgctgaggtc ggcgcccttt cctagagcgg ggtcgacgag
     4861 gtcctcgacc aggtcgggac gctggccgca acggatacga ggatcaacgg cgccacgggt
     4921 gtcgaaccgg gcggcgtccg ggaccgcgag cagcccgtag tcgacgtcgc cggcgaagcg
     4981 gaaggaggcg aagtgctcgc gcaggcgggt gactgcgcac tcggcccgct cccagcggcc
     5041 gccggtgctc ccgccgcccc caccggcccc ggcggcaccg ctgtccgcgg tctcgtcgag
     5101 gcactcggcc accacctgag cgggcggcct gaggcccgcg acgtccagcg cctcacgaag
     5161 cggcgcattg gcggcccagc ccgagcgttc cagacgcgcg atctcgtgat cgcggaactc
     5221 ctgcaccgac atcgtgttcc tccctgtcct cgatcttgtc cgtcgacatc gctgttcgcc
     5281 ggctcaccat ctcgccgcct ccagtacccg cccgatcggt cgctccaccg gtgaggtgcg
     5341 ccatgacact ggtgcgccgt gggcgaaagc gcgtgcgccc ggggcggaaa ccggagcccg
     5401 gagaggggcg cgagtcccgg agcgtgatct catagagcca tgaacacgac aggcaccccc
     5461 gtcaccgctc cggtgactgc gccgattccc acacccaccc ccgcggcgag tccccccgat
     5521 gcgcgcgaac tgaccaccgc cgaccgctgc gacgcctgcg gcgcccaggc attcatccgg
     5581 gtcgtcctgg cctccggcga actgctcttc tgcggccacc acggccgtcg caacatgacc
     5641 tccctggaga agcaggccct gttcatccag gacgagacct cccgcctgac cgcagacggc
     5701 tgaggggaga cgagagagcc cgagacggca tcgtctcgcg tcccagcgcg aacgaaacga
     5761 gggggcgccc cgcccgttcc gccaccgcgc gcgaggcgag cggcgttcac tcatgcgccc
     5821 cgtccacctc tcgccaaaga gcgtggaagt gatgaacggg accgtgcccg tgccccacgc
     5881 ccagggagtc ggcgtgctcc agggcgtcgg tgaggtatgc cttcgcatcg cgtacggtct
     5941 gcagccaggc ggcccggcgc ggtcgcaggg aggcgatcgc cgatgacagc gtgcagcccg
     6001 ttccatgggt gttcctcgtt ctcacccgac ggccgcgcag gagcgtgacg ccgtcagagt
     6061 cggcgtagac gtccgtagcc tcggcgtcga ggtggccgcc cttgaccagc acccgtcgcg
     6121 ccccggcgtc cagaaggcgc tgcgcttgag cgtgcagggc ccgcacgtcc ttcgcaggct
     6181 cctcgtccag caggacggcc gcctcgtgga ggttgggggt gatgaggtcg accagagtgc
     6241 acaggcggcg cacggcactg atcgcgtcct cgtccaggag cctgtcgccg gaggtagcca
     6301 ccatgaccgg atcgagcact gtgcacgtca accgcggcag gtagccgctc acggcctcgg
     6361 ccagcccggc ggtcgccagc atgccgacct tggtggcatc agggacgatg tcctccagga
     6421 gcgtgtccaa ctgaagacgt acgaagtcga ccgggacggt gtgcacgccc gtcacgccgc
     6481 gggtcgactg cgccgtcagt gctgtgaccg cactcatgcc gtaagcgccg agcgcgctca
     6541 tggtcttcaa gtcggcctgg atgccggcgc cgccgctggg atcggaaccg gcaacggtca
     6601 aagcggtgac ggtcatcgtg attccccctc gttccaggcc gagtgtaggg cggccgcggc
     6661 cgcgcggggg tcctcggccg cgcagatggc cgagacgacg gcaatgccgt tcagcccgcc
     6721 cgcgcgaagc gccggggcgt cggcgacagt gaccccgccg atggccacgg cagggaggtc
     6781 ggtcagagcg gccagacggg ctgcgccgtc gagacccagg cccgccggag cgtcgggctt
     6841 ggtgggggtg tcgcggatgg tgccgatgcc gacgtgatcg caggcgccct gctcgtcggc
     6901 gaggcgcagc tcatcgggag tcgcggctga caggcccaag aaggcgtcat ccccgatgag
     6961 ccggcgcacg aggacggccg gcaggtcggc ctggcccaca tgaacccccg ccaccgcggc
     7021 cgacaaacgg cgggcggcca ggaagacgtc gatgcggtca ttgacgatga ccggcacgcg
     7081 cccgccaatc gccccggcga ccgcgaggac ctcatccagg aaggcgccgc cgtcggcccg
     7141 cttggcgcgc aactgaacgc aggtgacacc gccggccacg gcctcctccg cggtccgcag
     7201 aacgctgcgt ccccgggaac ggcactgatc cgcgtcggtg acgagataga ccgacaggtc
     7261 cggtgcgggt ctcatgcctg ctcctcactg acggcgacgg cctccaggtc ttcggcgccc
     7321 aggtcgtaca gggcgtcgag gaacgcgggc cggaaggaac cgggaccggt cgagcgagcg
     7381 gcagcacgct gcgccgcagc actgtaaacc tcgtggcagg cgaccgtcgc cgcacgggca
     7441 tcgacgtcct gctcgcgtcc ggcggcgatg aaggcggcga tgagcgcccc cagagcacag
     7501 cctccgccgg tgacgcgggt gagcatcggc gagcctccgg tgatgcgggt catccgctgc
     7561 ccgtccacga tcgcatcgac gggccccgag accgccgcca cgaagccgtg gcgctcggac
     7621 atcgctcggg cggctcccag ggcggagtcg acgtcgtcgg cggtctccgg gccgcggccc
     7681 ccaccgcccg taccggccag cgccatgatc tccgaagcgt tgccgcgtac gaccaccggt
     7741 tccatggaga gcagatctcg ggccagggcc gtgcggtgga cgagcgatcc gacggcaaca
     7801 ggatccagga cccagggcgt gcccgcctcc ccggccgccg cggccgcctc ccgggcggcc
     7861 gcgcgctgct cgggctgggg cgtgccgaga ttgatcagca gaccggaggc cgcagcggcg
     7921 aaggtcccgg cctcaccggt gatgtcgacc atggcgggcg cggccccgct ggcgagcagc
     7981 acgtcggcgg tgaagcccgc cgccaccgag ttggtgatgc acgatatcag cggcgtcgtc
     8041 tcgcggacgg ccagaaggac ggaatgggcg cgagcgcatc tgcgcatgcg acaatccctt
     8101 cgtcagcatt gtccgaacag gttcgacggg tgtgttctca gccttgcggc accccgtgtc
     8161 ggtagaacca gacggtagca cggcagcggc ccgcagagca tcgccctacg ggccgccgat
     8221 gagcgggtgc gcagcgatca gtccaggtaa tcgcgcagca cctggctgcg cgagggatga
     8281 cgcaacttag acatggtctt ggactcgatc tggcgaatgc gctcgcgcgt gacgccgtag
     8341 actttaccga tctcgtccag cgttttgggc tgtccgtcgg tcaggccgaa gcgcatggag
     8401 accacgccgg cctcgcgctc cgagagggtg tccaggacgg cgtggagctg ctcctgcaga
     8461 agggtgaagc tcacggcatc ggcagggacc actgcctcgg agtcctcgat gaggtcgccg
     8521 aactcgctgt caccgtcctc gccgagcggg gtgtgcaggg agatcggctc gcggccgtac
     8581 ttctggacct ccacaacctt ctccggggtc atgtccaact cgacggccag ttcctcgggg
     8641 gtgggctcgc ggcccagatc ctgaagcatc tgacgctgga cgcgggccag cttgttgatg
     8701 acttcgacca tgtggacggg gatgcggatg gtgcgagcct gatccgccat ggcacgggtg
     8761 atggcctggc ggatccacca ggtggcgtag gtggagaact tgtagccctt ggtgtagtcg
     8821 aacttctcga ccgcgcggat cagcccgagg ttgccctcct ggatgagatc caggaagagc
     8881 atgccgcggc cggtgtagcg cttggccagg gagaccacca gacgcagatt cgcctccagg
     8941 aggtggttct tggcgcgctg gccgtcctga gcaacccagt gcagctcacg acggtacttc
     9001 gcctccaggt tatttccctc ggtggcgagc aggtgctcgg cgtacaggcc cgcctcgatg
     9061 cgtttggcga gctcgacctc ctgagcggcg ttgaggaggg cgactttccc gatctgcttg
     9121 agatagtcct tgacggggtc ggcggtggcg ccggcggtga cgaccttctg cgccggctca
     9181 tcggcctcat cggaatccga aacggtgaaa gagccgtcct tgttcctctc ccgcgacttg
     9241 cgccccgatc tcttggccgc ggccttctcc gcctgctcgc ggcggatgcg gtcgagctcc
     9301 ccggtcaggg cggcgatcga cgggctcatc ttgatgccct tgatgaccca accgcggaag
     9361 atgaagccat tgctcgtcag gaactcgcgg gcgacgacgg ggtcctcctc ctcggggatc
     9421 acgaagcggg gcactggtcc atggccgtag ggggccagcg taatgggttc ttcgagcgtg
     9481 ccgtcgcccg tgagctcgag cccttcgacg gtggtgcggc tgcgcacgta cagggtcgcc
     9541 ccgggggcga gcctgacccc tttgagagcg gccggcgtgt tgaagggctt gcgcttggag
     9601 ccgtcgccgt tggcctccag gctcacgtcc aggtagtagt cccgtagctc gggaacgggc
     9661 tcctcgctct cctcctgctc gctctgggcg gcttcggcgt tctcaccgtc cggatcggcg
     9721 ggggcggagt caccggagtc accggattcg tcgaggacga cctcgtcctc gagagccttg
     9781 tcgacgtcat cagcgcgctg agtgcgtttc cgcgtagctg tggaagaagc cacggagttc
     9841 ctttcacgtg agcgagtgat cggggtggga ggggcgccgc ggacgaacac gttcacgacc
     9901 aacgaagcgg ataaccgccc ggatgcagcg tttattccca ccacctccga tcgcggcccc
     9961 ggtccaccgc ccgatcgggc cgcccgttac gctgatgcgc atgagtgccc tctcccccac
    10021 gctccaggcg gtgcgcaccg ccgtcgaggc ccgactcgcc cgggccctgg acgctcatcg
    10081 tgcccgatgc accggcgagg cgcccgccgc cgatgagctg ttcgacgcgg ccgcggacct
    10141 gatgtcctcg ggcaagcgga tgcgcgcgct gctcggcgcc gtcggcctcg ccctgggtga
    10201 gccgggggcc gcaccggagc agcgatcccg tctcatgacg ggtgccgcct ccgcgagtct
    10261 cgggtcggcc ctcgagctgt accaggccag tgccctggtc cacgacgatg tcatcgacgc
    10321 gtccgccact cgccgtggcc gccccacggc ccaccgccga tgggccgccc agcacgtctc
    10381 gtcgggctgg cgcggggatg ccgccgccta cggcgaaggc gccgcgatcc tgctgggcga
    10441 cctgctgctg tcgctcgccg gaatcgagat cgggcgggcc gtccgaccgc tcgccgacgg
    10501 agcgcgggcc ggggcggtcc gggacgcctt cgacgtcatg acagccgagg tcgccgtcgg
    10561 tcagttcctc gacgtgcgcg gtgaaatggt ccttccgccc tcccccgacg acgacccgat
    10621 cgcctcgggg cgggtcatgc tcacctcggc cctgaccgtg gtcaggcgca agtccgcccg
    10681 ctactcggtc atgcatcccc tggtcatcgg cgccctcctg ggcggggtga cgtcggccga
    10741 ccctctgcac aaggcgctgg agatcttcgg agaggagatc ggcatcgctt tccagctgcg
    10801 cgatgacgtc ctgggcgtct acggggatcc cgacctgacc ggtaagccgg caggcgacga
    10861 cctgcgcgag ggcaaacgga ccgctctgat ggccatggcg tggcagcgcg ccgaccggcc
    10921 cggccgcctc ctgctgtccc gagtcctgac cgaccgcgac gcctcctccg aactgatcgc
    10981 cgccgcggcc gacctcattc gcgactgcgg cgccctggag gcgcacgaga agacgatcgc
    11041 cgcccatgcc cgggcgggtg tccgcgccct ggatgatgtc ccctcgggag cgctcgacga
    11101 cgccggtcgc gccgacctgt cgtccctggc ccgggcgctg acctcgcgca gctcctgacc
    11161 tggacctgcg ctcggaccgg tcagcgcggc gcaggcgaat ccggccccgt cagcgcctta
    11221 gaatctgccc gtggtcaagg atccgctcat cggtcgactg gtcgactctc gctacgagat
    11281 cgtcgaccgt gtggcgcgtg gcgggatggc gaccgtctac cgggcgcacg accgcaggct
    11341 cgaccgcgtc gtcggcctca aactcatgca cgcccattta gccgactccc ccgacttcgt
    11401 agcccgtttc cgcagggagg cgcgcgctgc ggcgcgcctg tcgaacccgg gcgtggtggc
    11461 ggtctacgac cagggcagcc tcgacggcgt cgcctacctg gtcatggagt acgtcgaggg
    11521 cccgaacctg cgcgacctca tcgccgccgg ccccctgtcg atacgagagg ccctgggcct
    11581 gacggcccag atcctgcgcc cgctgggagc cgcccaccgt gcgggcctgg tccaccgcga
    11641 catcaagcct gagaacgtcc tgctgcccgc ggacggctct gtcgccaaag tcgccgactt
    11701 cgggctggcc cgagcggtta ccgaagtgac gcagacaacc accggtaatg tgctgggcac
    11761 cgtggcctac ttagctcccg aactcatcac ctcgggcagt tccagccccc gtgcggacgt
    11821 attctccgtg ggagtcatca cctacgagct gctcaccggt gagcagccct tcaccgccga
    11881 ctcccccatc cagatcgcct tccgcaacgt ccacgaggac atccccctgc cctcgaccac
    11941 ggtcccggac ctacccggcg gagtcgacgg gctcgtgtcc gccatgacgc gccgcgaccc
    12001 cgagcagcgc ccgcaggacg ccgatgagac actgacccga ctgcgcgagg cagtcgccga
    12061 tctgagcgag tcggaacttg cggtcaagcg cggtggcggg cccggctcgg tgcgcacgca
    12121 ggaggtcctc gcagccaatg ccgagatcgc ccgcacggcc atgggcgcgc agtcgccgga
    12181 cgagaccgtc gatgaggagg attcgcaaac gacaccgggg gcgggcctgc gcacagtctc
    12241 gctgccgatc ggctcgatag gcccgcaggc acagggcggc ggcgacgggc gcacgcggca
    12301 gctggcgcgt gaggagttta tgcgcgccga cgatcaggat acggccgcgg tgccgcacaa
    12361 cgaccagcgc cggacgctcc ggcgccgcgc cgtcctggga gcggcggcga ccgccctcct
    12421 gacagtaaca ggcaccggca tcggagcctg gtacgccttt aaaggtccgg gacgctccgt
    12481 ccccgttccc gagatcgtcg gtcagacggc cgaggacgcc cagaagtcgg tcgagaccgc
    12541 gggcctgacc tgggccgctc ccaaccggga gtactcagat acgatcccgg ccggatcagt
    12601 ggtctcctgc gagccgggac cgggcgacgg cgcgcgcccg ggccaggcgg tcaccgccgt
    12661 cgtctcccgc ggcgtggagc agaagaaggt tcccgatgtc gtgggcgagg cccaggacga
    12721 ggccgtcaag gccattacgg acgccgggtt gagcccgggc gcgatcaccc aggactactc
    12781 cacctccgtg gcctccggcc tggtggtctc caccgacccg gcggcggggc agagcgtcaa
    12841 ccattcctcg gcggtggcga tcgtcgtctc caagggacgc cagcccgcca ccgtgcccga
    12901 cgtggccgga atgaacatcg agcaggccac aacgactctg gaggcggccg gtctcaggct
    12961 gggcgcgcaa acccgggtct tctccgactc cgtgactgcg gacctggtgg tctccaccga
    13021 cccggcggcg ggcgatacca gcgtccacca cggggacgcg atcggcgtgg aggtctcgaa
    13081 ggggccggag acggtcacgg tccccgacgt caagggcatg aaggaggacg aagccaccag
    13141 ggcgctcaag gacgtcgggc tggaggcgac ggtttccacg tcgtggggcg ggcttctggg
    13201 caaggtccga tccaccgacc ccgtcgccgg gacaaacgtc gcgaagggct cgacggtcac
    13261 cctccacatc atctgacgct gtccgaatgc tcagaccggg gacccccgaa ccagccgtct
    13321 cacgtcctcg tctcgccgag tcatccacct cgcgcgcgat gcggactgac gaacccgacc
    13381 ggccaacgct cagccgcgca gcatctcggc gacctcgaaa gccatctcca gggactgctg
    13441 gtggttcaga cgcgggtcca cgagcgtttc atagcgctcg ccgagggtgg cctcctcgat
    13501 gtgctcgccc ccgccgagga cctcggtgac gtcgtctccg gtcagctcga cgtggatgcc
    13561 gccgggcacg gtgcccaacg cccggtggac ctcgaagaag ccgcggacct cgtccatgac
    13621 cgtgtcgaag cgacgggtct tgtagccgtt gtccgaggtg atggtgttgc catgcatggg
    13681 gtcggtgacc caggtgacgg ggcggccgtc ggcacgcacg gcctcgatga gtgcgggcag
    13741 ggcctcgcgg atgcggtcgg cgcccatacg ggtgatgagc gtgagacggc cggcgtcgcc
    13801 gtgagggttg aggcgatcga tgagggcgac gagctcggcg ggcgcggtcg tcgggccgac
    13861 cttgacgccc accggattgc ggactcctct cagaagggcg acgtgggcgt gctcggcccc
    13921 gcgagtgcgc tcaccgaccc acaggaaatg agccgaggtg tcgtagaggc gtcccgatcg
    13981 ggagtcctca cggatcatgg cgtcctcgta ctccagaagc agggcctcgt gagcggcgta
    14041 gaaatcaacc tgcctcaggg cgtcgaagtc gaccccggcg gcctccatga agcgcatggc
    14101 gcggtcgatc tcctcggcga aggactcgaa gcgcgcgtaa gcggggttgg ccgtgaagcc
    14161 acggttccag gaatggactt cacgcagatc cgcgtaccct cccatggtga aggagcggat
    14221 gaggttgagg gtggtgccgg cacgcaggta ggcgttgagc atgcgagccg gatcagggac
    14281 gcgagcggcg agcgtgaagg cgtgatcgtt gacggagtcg ccccggtagg agggcagggt
    14341 gacgccatcg cgcgtctcgg tgtcggcact gcggggcttg gcgtactgcc cggctatccg
    14401 ccctatcttg accaccggtg tggaagcccc ataggtgagg accgcagcca tttgcaggat
    14461 ggtctgaagc ttgagacgga tgttatcggc cgtgttgtcg gcgaaggatt ccgcgcagtc
    14521 gccccccatg agcacgaagg cgcgcccccg gccggcagcg gccatctggg tgctcagggc
    14581 gtcgacctcg ccggcgaaga cgagtggagg gcggcttcgc aggtcgtcgc tcaccgcttt
    14641 cagggcatcc gcgtcagggt aggccggctg ctgggaggcg gggcaatcgc gccagccggc
    14701 cgcggtgcgt ggggcgttga gctcgttcat cacacgggca tcatatggcc gtctgcgtgc
    14761 gccccggcgc cctccatgaa gcagaatgcc gggcccgatg gtgaccggcg caccgccgac
    14821 ggcgcaccgt caacgctcag tgccccgaag cggcttcggc gggctcgacg atctggccga
    14881 gatcccccat gagggaagtg aaccagggcc gggagatatc gaagggcttg cccccggcga
    14941 tgcgtgggaa agcgatggcg ccgaggacgt cgtcattctc ctcatcctgg ccgatgacac
    15001 ccgactcgcc gcgctgggcg caatcgacgg ccacgtcgca catggacttg atgaggttga
    15061 gatcctcagc cttggcgttg gtggcgcgcg aatagtagcc ggacttctga accatgacct
    15121 tctcggcacc gatgaggccc gcgaactgcc ccgcgaacca ctggcccgga ttgatggtgt
    15181 cgagcttgac gtggccgaag ggatcgcgct cgacctcctc gccgcgagcc tccttctccg
    15241 caatgatctc agggacgccg gcgccctcgg acaggaagat gttgacgttg ccctgctcat
    15301 ccatgagggc cttgagacgc ttggcctcgg ctgccaggtc gagcttcatc tcgggcagga
    15361 agacggcgtg aacgtcccag cgctcgcggg tgagccccag cgagggcgcc cacttcctgg
    15421 atttgagcag ctcatggtag cgacgggcgg tctcggcggt caggtagccg cagttgcggc
    15481 ccatgcactc gtgaatgatg agcatgcgcg ggttggagcg gtgctccccg atgacgttga
    15541 aggcgaagcc ggcgccctcc tcggcggccg accaggcgcc cagcgactgg cggatcggaa
    15601 cgatgtcgtt atcaatggtc ttgggcaggc cgacgacagt gagctcgtag tcgtgctcgt
    15661 gaaggtaggc ggccagatct gcagcggtgg tgttggtatc gtccccgccg atggtgtgca
    15721 ggacgtcaac gccgtccttg cgcagctgct ccgcggcgaa ctccagcggg tcgatgccct
    15781 cggccaccag gccgcgctcg acgaggttct tggcgttggt gagcttgacg cgggagttgc
    15841 cgatcggaga accgccgtac tcgcgcagaa cgccggcgtc cttgcgtccc tgcgcgtcga
    15901 cgacgatgta gttgccggtg agcaggccgt ggtaaccgta ctggtaggcg atgatctcga
    15961 cgccgggggc aacctcggtg tagcgctcga tgaggtcgcc gacggcggcg gacagacagg
    16021 gggcgaagcc gcccgcggtg agcagagcga cgcgacggat cgacatcgat ggcctttcgt
    16081 tgggaccggt tttgacgggc ccatcctagc ggggcggacg cgccgaggga caagaagatc
    16141 ctgcagcagc gcgattgagc gacgggactc ccgctcccga tacacgcccg cccatgaccg
    16201 acggcgatgc cgccaaccgc cgcggggtcg ctgaggcgcc gactgtccgt ccccgggcta
    16261 ctgtctgccc tcggtcggat cccggggctc gtcgtcagag gcatgcgacg ccccgccctc
    16321 cgtctcatcg ggcggctcgg gcacttcgac gtcgggggcg ggacgaccgc cgggcgcgga
    16381 caccggcgcg gcggccggcc gcttgagcgc ttgagcccga agcatctcgg agacgacctc
    16441 gtcagcggac atcttctcgg cgtccatcgc cttcttgaca tcggcggcgt acaggtcgac
    16501 gtattcctga ccggacagcg ccatgagtga gtacatgatc tcgtcagtga tcgagcgcag
    16561 cacgaaacga tcgttctcca gccccttgta ccgggagaaa tccaacggct caccgacgac
    16621 gatccccacc cgatgccggg tcgaggggat cgcctggccg atcggctgag caagatccga
    16681 gccgatcatg gccaccggga tcacaggggc ccccgtggcc agggcgatgc gcgccacccc
    16741 cgtcttcccc cggtagagac ggccgtcggg actgcgtgtg ccctcggggt agatgccgaa
    16801 gagctcaccg gatctcacac ggtcgatgcc agcctgcagg gccgcctgcg aggcccggcc
    16861 gcccgaacgg tccacgggaa tggtgccgac ggctgtcatg aagttcttga cggcccatcc
    16921 tttgagccct ctgccggtga agtagtcgga cttgccgatg aaggcgacct cgcggtccac
    16981 cagcagcggc aggaagaagg agtcgatgac ggccaggtgg ttggaggcca ggatcgcggc
    17041 cccctcgatc gggatgctct cctcccctcg gatccacggt tgatagagca tctccagggc
    17101 gggaccgaca gcggtcttga tgcctcggta ccccacggga cctcctgtgc tcggcggctg
    17161 actggcgctc ttcaccgggt ccgtgggccc gcacggacgg gcgcgggcgc ggttggatcg
    17221 gcgccttggt gaagtctagc ctcgcactgt ggtcgatcat gcgcctgtcg gaccctcgat
    17281 cggaggactc gcgggacccg atgcccctgt cgacgctcgg gcgcagttcc cggaccgctg
    17341 cccgagcagc agccgcaccg ccggcctgca ggcctctttc gaggatatgg gcacgcctct
    17401 gcgagaggtg gccttcgtcg tggtcgacct ggagaccacg ggcggagcgg cgggcgccca
    17461 cgccatcacc gagatcgggg cggtgcgggt gcgcggcggc accgtcgagg aagagttctc
    17521 cacactggtc gacccgggca gggccatccc ggcgcagatc acggtgctga ccggcatcac
    17581 caatgcgatg gtggccgggg ccccgtcggt aggcgaggcg ctggtctcct tcctggaatg
    17641 ggctcgctgg tccgaggcgg acacggttct ggtggcgcac aacgcgcgct tcgatgtcgg
    17701 tcatctgcgc cgggcgtccc gagaactggc attgccctgg cgggagccga cagtgctgga
    17761 caccctcgcc ctggcccgcc ggacctgggg gcgctcggat gtgcccaacc accgtctggg
    17821 aactctggcc tccttcgtcg gctcccctac caggccgact caccgtgccc tggacgacgc
    17881 gcgggccacc gtcgacgtcc tccacgccgc ccttcaggtc ctggctccgc agggcgtcac
    17941 ccatctggag gatcttgcca cggctaccga tccggtaccc gcgcggcgcc ggatcaagag
    18001 ccgcatggcc gacggactgc ccaccgggcc gggcgtctac cgtttcctct cccgaaccga
    18061 gcaggtcctg tacgtcggct cggcggtcaa cctgcgccga cgagtgcgct cgtacttcac
    18121 cgctgcggag aagcggccga cgatcgcccg gatgctggag acggccgtcg gggtgcgggt
    18181 tatcgagacg gccaccgaga tcgaggcgcg agtgcgcgag ctgcggctca tcgccgagct
    18241 caaccctccg gcgaaccgac gctcccggac accgcagcac cggccctggg tccgcctggc
    18301 ggacgccccc gagccgcacc tggtgacgac gacggcgctg gcgagcgacg acgtgctcag
    18361 cgccgtcggt cccttcccct cgcgttcggc ggcccgggag gcgatccgcg cggccgagtc
    18421 ggtgctgcgg ctgcgagcct gggacgggcg ggcgctgaag tcgccgatcg ccggcggcac
    18481 ctcggcggat accggcaccg cgatgcgcgc actgtcgggc gaggtggatc tggtggccgt
    18541 ccccgtccta agacgcgtgg aggagctggc cgctcgggag cgttacgagg aggccggagc
    18601 gtggaccgcc cgcctgcgct ccctgctgct gggggcgagt cgggcggagc gggtcaggcc
    18661 gctcctgacg tgcccgcatc tgatcgcggc gcggcgacgc gatggcggcg gctgggagct
    18721 ggtcgctgta cgctgggggc ggctggcagg aagcatgacc acaccagcgg gggcggaccc
    18781 gcggcccgcc gtcgatgccc tgcgggcgac ggcgcaggtg gtcgagcgcc cgcagcgcgt
    18841 gggaatgggc gccggtgttg acgagaccct gctgctggcg gactgggtgc tcgacgccgg
    18901 agcgcgcctg gtggaggtcg cggactgcgg gaatgaggac gggagcggct gcgccgtcct
    18961 gagctggccg atcggagccg ctgcgcgcca tcgccgggtc ctcgactcgg gaccctagcc
    19021 ggtcggaatc cgagtccccc acgaaagtcg aattgcgcgg gcggggacga aacgccgggg
    19081 atgcgggaat tccgccgaga accccgcctt cacccggatc ggccggaacc gaccccgatc
    19141 cagagggggc gccgggcctc gccccggacg aaaacgaatc ggtcagccgg ccgggacgac
    19201 cgcgccgcgc cgagcccgaa aggccttggt cacgccttcc tggagagcca tcgggtcgag
    19261 aggacggggc acaacggcct cggccttgga ccaggcggcg agccagtcgt cctgcggacg
    19321 ggcagtgagc agcaccaccg ggggacgact gtcgagctcg gtgaacagct cgtgggccag
    19381 acccatgccg ccgaacttct tggtctcggc gtccagcaca aggacgtcaa aaggcgcctt
    19441 cccctctttg gcccgatccc tgatggccag cctcacgcct tcggccgtgg cggctctggt
    19501 ccaggacacc agcggcagtc ccctggcggg gcgccggccg acgccctcga tcacctcctg
    19561 acgcaccgag gcgtcgtcgg agaagacgag gagctcgaga cggtcggtcg cggcctggtc
    19621 ggtcatgctg tcctccaaga cggggcgggg ctcttccgca gtcagtgtaa tcgcccacgc
    19681 ggtcccgtcc gactcaccaa tcagcgtata ccatgaatgc tgtccgatac ggcgggtcct
    19741 aactatggaa ccgcttatgg aaccgatcgc atccgacccg cgaacccacc gatgaaaggc
    19801 acgcaccatg gccctgtaca cacttcccga gcttccctac gactacgcag ccctcgagcc
    19861 ccacatctcc gggcggatca tggagctcca ccacgacaag caccacgccg cctacgtcgc
    19921 cggcgccaac accgccctgg acaagctccg ggccgcccgc gccgccgatg acttcgccgc
    19981 ggtgaacctg tgggagaaga acctcgcctt caacctcggc ggtcacatca accactcgat
    20041 cttctggaag aacctctccc cgaacggcgg cggcgaaccc gagggcgagc tggcggaggc
    20101 gatcagggac tccttcggct ccttcgaggc gttcaagaag catttcaccg ccacagcgct
    20161 gggcatccag ggctcgggct gggcggtgct cgcctacgac tccgtggccg gcgggctcgt
    20221 catcttccag ctcttcgacc agcagggcaa cgttccggtc ggcactatcc cgctcttcca
    20281 ggtcgacatg tgggagcacg ccttctacct cgactacctc aatgtcaagg ccgactacgt
    20341 caaggccatc tggaacatcg tcaattggca ggacgtgtcc gagcgtctgg ccgcagcggt
    20401 cgctcgtacc gagtcactca tcgtgcgctg agggtcggac acgcagaggg ccggccggac
    20461 ccaggtcaac gactcctggg ctccggccgg cgtgaggacc cttaacgggt ccgccgtgcc
    20521 cgctgagagc tcgcggaccc agagcttggt cagagcttgg tctcgatatc catgacgtag
    20581 gccgcagcgg gtgcgggtgc ggtggatccc ctcctcgtgg cggtcccggc cgcctgaagc
    20641 agaaccacgc gcgaacccac cggaactccg atgagatccg ccagccccgg agcctgggcc
    20701 atggtgatcg tctgaggcag gcctgtgtcc caggtggact cggaggcgga atcgtcccac
    20761 gtggtcatgg ccgtgttgac gcctatgacg tcctgatcgg tgatcggatc gcccgtaccg
    20821 cgtgccagga cgatgacctt ggtctcggtg ggctccgtcg ccccctcggc caccgagacc
    20881 gttgcggggg caccgaggtc accagagacc gacacacccc aggacgccgc atccgcctca
    20941 ccctccatgg tggctccggc ggtggagggt gcggccacga cgtcgacgac gaagacgagc
    21001 gggccggtcg gtcggccctg actctgatcg tcgccgtaag cgagatcaga ggggacgccc
    21061 accaggagcc gatcacccac ccggtgcccc accaggccgc aacgccagcc gtcgacgact
    21121 ccccgcaggg agaagctcga cggctctccg cggtcgaa
//
