LOCUS       NZ_GL985606            23460 bp    DNA     linear   CON 21-JUL-2024
DEFINITION  Actinomyces sp. oral taxon 448 str. F0400 SCAFFOLD1, whole genome
            shotgun sequence.
ACCESSION   NZ_GL985606
VERSION     NZ_GL985606.1
KEYWORDS    WGS; STANDARD_DRAFT; RefSeq.
SOURCE      Actinomyces sp. oral taxon 448 str. F0400
  ORGANISM  Actinomyces sp. oral taxon 448 str. F0400
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 2812018)
  AUTHORS   Muzny,D., Qin,X., Deng,J., Jiang,H., Liu,Y., Qu,J., Song,X.-Z.,
            Zhang,L., Thornton,R., Coyle,M., Francisco,L., Jackson,L.,
            Javaid,M., Korchina,V., Kovar,C., Mata,R., Mathew,T., Ngo,R.,
            Nguyen,L., Nguyen,N., Okwuonu,G., Ongeri,F., Pham,C., Simmons,D.,
            Wilczek-Boney,K., Hale,W., Jakkamsetti,A., Pham,P., Ruth,R., San
            Lucas,F., Warren,J., Zhang,J., Zhao,Z., Zhou,C., Zhu,D., Lee,S.,
            Bess,C., Blankenburg,K., Forbes,L., Fu,Q., Gubbala,S., Hirani,K.,
            Jayaseelan,J.C., Lara,F., Munidasa,M., Palculict,T., Patil,S.,
            Pu,L.-L., Saada,N., Tang,L., Weissenberger,G., Zhu,Y., Hemphill,L.,
            Shang,Y., Youmans,B., Ayvaz,T., Ross,M., Santibanez,J., Aqrawi,P.,
            Gross,S., Joshi,V., Fowler,G., Nazareth,L., Reid,J., Worley,K.,
            Petrosino,J., Highlander,S. and Gibbs,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2011) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Standard Draft
            Current Finishing Status          :: Standard Draft
            Assembly Method :: Newbler Assembler v. 2.3-04192010
            Genome Coverage                   :: 32.58x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220835.1-RS_2024_07_21
            Annotation Date                   :: 07/21/2024 00:51:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,460
            CDSs (total)                      :: 2,404
            Genes (coding)                    :: 2,339
            CDSs (with protein)               :: 2,339
            Genes (RNA)                       :: 56
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 20 of 65
            Pseudo Genes (incomplete)         :: 50 of 65
            Pseudo Genes (internal stop)      :: 5 of 65
            Pseudo Genes (multiple problems)  :: 9 of 65
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:02:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 335567
            Orig. end                         :: 359027
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GL985606.1.
            Actinomyces sp. oral taxon 448 strain F0400
            Strain source, body site: Oral
            Inquiries should be directed to microbe@hgsc.bcm.tmc.edu
            This is a reference genome for the Human Microbiome Project. This
            project is co-owned with the Human Microbiome Project DACC. This
            sequence is generated as a part of the Human Microbiome Project
            (HMP), funded by the National Institutes of Health (NIH), National
            Human Genome Research Institute (NHGRI) Large-Scale Sequencing
            Research Network and the National Institute of Allergy and
            Infectious Diseases (NIAID) Microbial Genome Sequencing Centers
            Program. The mission of the HMP is to generate resources to enable
            the characterization of the human microbiota, the microbial
            communities living within human bodies, and analyze the role of
            these organisms in human health and disease. See
            http://www.hmpdacc.org/ for more information.
            The sequenced strain was obtained from Dr. Jacques Izard (contact
            information: Forsyth Institute, Department of Molecular Genetics,
            140 The Fenway, Boston, MA, 02135). The genomic DNA was prepared
            from a single bacterial isolate. The sequence generated included at
            least 10 fold coverage of Roche/454 Lifesciences FLX fragment data
            and at least 8 fold clone coverage of Roche/454 Lifesciences
            paired-end data. The Roche/454 Lifesciences sequence was assembled
            using the Roche/454 Lifescience Newbler assembler. This draft
            assembly meets the HMP draft quality standards (more than 90% of
            the genome is included in contigs, more than 90% of a core set of
            bacterial genes are found with > 30% identity and > 30% length;
            more than 90% of the bases in the assembly have more than 5 fold
            sequence coverage, the contig N50 length is greater than 5kb, the
            scaffold N50 length is greater than 20kb, and there is less than 1
            gap per 5kb).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23460
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23460
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23460
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13460](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13460)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    945..959
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    2777..2791
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(2815..3639)
                     /locus_tag="HMPREF9062_RS01515"
                     /old_locus_tag="HMPREF9062_0331"
     CDS             complement(2815..3639)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017177039.1"
                     /locus_tag="HMPREF9062_RS01515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0331"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_034253499.1"
                     /transl_table=11
                     /translation="MRSTTTRGEPADDADGLTVGRTARLVGVSVRTLHHWDEIGLVRPS
                     TRSWAGYRLYDTDDVARIHQVLVYRETGMSLAEIARILDSPDVDPRAHLARQRELLTDC
                     IAHLTRMLRAVDTMMEETMNETDLTAARRASIFGTDWGEQWREEAEERWGGTDEWAQSE
                     ARKAAMTQEDWARVAQESLQLITALVDAKREGVKPGSRRANELAEQHRASIDQWFDTTH
                     SKQVLIARGYVADPRFTEFYDGHEAGLTAWLKEVIDANAAAHGVDPANACWE"
     gene            complement(4073..5374)
                     /locus_tag="HMPREF9062_RS01520"
                     /old_locus_tag="HMPREF9062_0332"
     CDS             complement(4073..5374)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017177874.1"
                     /locus_tag="HMPREF9062_RS01520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0332"
                     /product="MFS transporter"
                     /protein_id="WP_009409862.1"
                     /transl_table=11
                     /translation="MRLTADLKDLATVPAFRALLGVRLVSQTGDGMVQAGLATLFFFRP
                     QNMTDAAGVAAALVVMLLPFSVVGPFTGPFIDRWRRRQTLLVGNLVRAGLIGATALCLS
                     TVGIGPPVYALVLIALGVNRFLLSVLSAGLPQIIDHERLLVANSIVPTLGGAASAMGAV
                     LGILMRLTLPEGAQDTASLVAAVALYTLAAGVVTRLGRDELGPERVDRSTGLAPALAAT
                     ADDLAAAVRYLIRRGTPGLALITMALHRFVYGMELITLILAARNLLAAPENADVGLALF
                     GTLMGAMVAGHGLAVVLTPLAHERVTPPTWVVMCLIGGTVGQIVLVVTHSVTAMTAGLF
                     VFGVGVQGAKIAVDTIVQADTADAFRGRAFSIYDVLFNSAECLAAGVSVLVLPDVGWSR
                     TVQAVLVVVVWMVAAGYRCAVRRLGGGPRDVPAV"
     misc_feature    5399..5408
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(5555..7066)
                     /locus_tag="HMPREF9062_RS01525"
                     /old_locus_tag="HMPREF9062_0333"
     CDS             complement(5555..7066)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0004557 - alpha-galactosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009402679.1"
                     /locus_tag="HMPREF9062_RS01525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0333"
                     /product="glycoside hydrolase family 36 protein"
                     /protein_id="WP_009409863.1"
                     /transl_table=11
                     /translation="MIHHLEFAGWRLAIACDGPVVSTTGAEAIVSAGRLTVLHDMPDAL
                     VYRTGQNSWSPAGWRRLGESPMRISDPARRRTADDDIWDDPVRHHSAWLTVLAEDDRSG
                     EEDGRALLVGCLEGDTPRVRADTAALEALTETGSRAEWMIRVGTVTEVLVAYARAAGRH
                     LGRRPIRPRSVWCSWYSYYEDVSQAALEDELDAIASLGVDTLQIDDGWEAAVGDWAPGE
                     RFPDGMAHIATRIRRAGMEPGLWLAPFIALSGSRLAATRPELFVTGPDGAPAVAGSNWG
                     TTYHALDLTRPEACDVVHETVARAVHEWGFGYLKLDFINAAAIPGRRHEEIDREHAYRR
                     GIGVVRRAAGEEAFLLGSGAPVMPSIGLLDAVRIGPDAAPMWDNYATDDPSDAMALNAL
                     RTSINRLWLGEVIGIDPDVVFFRHRRNLLSDEQMRWLQELAAACRFRCLSDRPAWLDAR
                     EKDAVRAFVAGHEDVDLTGRYRFRLDGRKVDLTDAVLGGGSRYPL"
     gene            complement(7147..8337)
                     /locus_tag="HMPREF9062_RS01530"
                     /old_locus_tag="HMPREF9062_0334"
     CDS             complement(7147..8337)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730785.1"
                     /locus_tag="HMPREF9062_RS01530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0334"
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="WP_009409864.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 8.3e-36, bitscore:
                     120.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTRKQFRVQTFNAISGAGLSRFPDDLYDVGASLADPDALLVRSA
                     KLHDTPIPDSVLAVARAGAGTNNIPVADMTERGVPVFNTPGANANAVKELVLAGLFIAS
                     RNLIPAARFAHTLEGDDAAIARAVEAGKKQFIGFELPGRTLGVIGLGAIGVQVANAALG
                     LGLSVVGFDPGISVEHAWHLSAEVERAESIEDVFRRADILTVHVPLIEATRGLVSTQRI
                     ALMKDSAVILNFARAEIVDEGAVISALDADALRGYVCDFPSTNVHKHPKCISLPHLGAS
                     TREAESNCAIMAVDELRGFLEDGQVHNSVNFPEAVMPREEGTHRVLIVNRNVPNMVGQV
                     STIVAQHGENIANLLNRSRGELAVTLVDVEGEVELPTLEELRGIDGVLSARLISAA"
     gene            complement(8488..9570)
                     /gene="serC"
                     /locus_tag="HMPREF9062_RS01535"
                     /old_locus_tag="HMPREF9062_0335"
     CDS             complement(8488..9570)
                     /EC_number="2.6.1.52"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0004648 -
                     O-phospho-L-serine:2-oxoglutarate aminotransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006564 - L-serine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (2-348). E-value: 1.1e-50.
                     Score: 164.6. Matches aSDomain:
                     nrpspksdomains_HMPREF9062_RS01535_Aminotran_5.1"
                     /codon_start=1
                     /gene="serC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009409865.1"
                     /locus_tag="HMPREF9062_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0335"
                     /product="3-phosphoserine/phosphohydroxythreonine
                     transaminase"
                     /protein_id="WP_009409865.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.6e-51, bitscore:
                     171.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVYNFSAGPAQLPLPVLEQAASELTDWRGSGMSVLEVSHRGKDF
                     VECAADAEAALRSVASIPDNYKILFLAGGATGQFTAVPANLAARGERVAFLNTGQWSAK
                     AIKEARRQGVAVDVIADEAASSYTTTPGPGSFVVPADAVYLHYTPNETIGGVEYPDIPD
                     AGDVPLVADMSSAYFSRPIDISRFGVVYGGAQKNLGPAGLAVVLVREDLLDRARPDVPA
                     IWDWKVMANKDSMLNTPPTFSVYLLDLIAHWIESTGGLAAMGERNRAKAARLYRAIDAS
                     DFYTNPVEERSRSRMNIPFTLADSSLDADFLAGAESAGLTNLQGHRSVGGMRASIYNAM
                     PIEGVQALIDYMVEFERTRA"
     aSDomain        complement(8527..9564)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HMPREF9062_RS01535_Aminotran_5.1
                     "
                     /evalue="1.10E-50"
                     /label="HMPREF9062_RS01535_Aminotran_5.1"
                     /locus_tag="HMPREF9062_RS01535"
                     /protein_end="348"
                     /protein_start="2"
                     /score="164.6"
                     /tool="antismash"
                     /translation="VYNFSAGPAQLPLPVLEQAASELTDWRGSGMSVLEVSHRGKDFVE
                     CAADAEAALRSVASIPDNYKILFLAGGATGQFTAVPANLAARGERVAFLNTGQWSAKAI
                     KEARRQGVAVDVIADEAASSYTTTPGPGSFVVPADAVYLHYTPNETIGGVEYPDIPDAG
                     DVPLVADMSSAYFSRPIDISRFGVVYGGAQKNLGPAGLAVVLVREDLLDRARPDVPAIW
                     DWKVMANKDSMLNTPPTFSVYLLDLIAHWIESTGGLAAMGERNRAKAARLYRAIDASDF
                     YTNPVEERSRSRMNIPFTLADSSLDADFLAGAESAGLTNLQGHRSVGGMRASIYNAMPI
                     EGVQAL"
     gene            complement(10001..11263)
                     /locus_tag="HMPREF9062_RS01540"
                     /old_locus_tag="HMPREF9062_0336"
     CDS             complement(10001..11263)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="HMPREF9062_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0336"
                     /product="nitroreductase family protein"
                     /protein_id="WP_172634819.1"
                     /sec_met_domain="PF00881 (E-value: 5e-09, bitscore: 33.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQCSSDPDVALEVENPDGGEWLDLRTLGEGLTPAEYSMRYGRLTR
                     LAGTGRVRSRISVGDDVIATVTGPHALLDSAPDIDASGLEASPDVYMRPRHGAFIVACL
                     STRAVVHMSSPGASYLMAPDSAPEGVLSAFTALRLLAHAGASTALTDPADDWWSFDEAL
                     PLIRSRAGTHVGAYGGTYRRSKTHGGMPTVRRPVVRAGTREETVNVEYPDDGLSLSAAL
                     GERRSRREHAGDPAELSDVVQVLARSAIGARIGTGPQGEHLFRFPYPCGGSLGELDFVI
                     IANRGSHHGEPLSGRAFEYSPLRSTLSELTTDPVGVRETVRTYSQIAGVAADELQYVVV
                     VLADAARVLAKYESVGPALILKHVGAWMQTMYLCAEDSDLGVCALGGGPGDVLPRLCGA
                     DIDDPTRAVAVGEMIVAGRAE"
     gene            complement(11247..13460)
                     /locus_tag="HMPREF9062_RS12025"
                     /old_locus_tag="HMPREF9062_0337"
     CDS             complement(11247..13460)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR00702.1"
                     /locus_tag="HMPREF9062_RS12025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0337"
                     /product="YcaO-like family protein"
                     /protein_id="WP_009409867.1"
                     /sec_met_domain="YcaO (E-value: 5.9e-68, bitscore: 227.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNAVASTEAFSESDDFAVMPNPRYRYVERNSERSIAVLADHDLR
                     EIKGDAARILRACLTGEMHDLISGDTMPLAAAYGAVELLRRLGILVDEYPVARLGDRFP
                     DASSFPRRTHVIDLLGSQDLVAALSRALVGLQPGINVDIVLVDDYKARACRRALDEAGA
                     RGDAVAFGALVDNRLFVGPFAPAGSGVLDDLIFALRFNDRAAQIGGSVLRSPLPLDRIR
                     KTATPFALTMREQLDEWFTRGHCRAEEAIIELVEIGSGRRVHPIRRQPHSQDVAPATEA
                     IPLDLRTRGTDAIGRSVSTADFLERNAHLLSDVTGVVRELERLDDPNDPDSPAHVYVAG
                     HNWALRTDDPAVLRRSLRGQSGGKGRTDAQARAGGLAEAVERHSAIAVGRERRRRARFT
                     DLPSAVHPNAVQLFSDRQFASREERNRANDLYNYIPEPFEENALVDFTPVWNPVDGSTA
                     WMLTALCYFMFPNAAASPGSVDGVGRRFARADSNGYAAGATRADAAFQGLAELIERDAV
                     ALWWYNRVRRPAVDLESLDDDYLRSTKRWLDTLERDLWLLDLTTDIGVPVVGAVSPARD
                     GGACDQILLGFGAHTDVRQAAVRAVAEVLQFRASIPPEVWHRPDAGRPSGGEAIEWLTR
                     ARLAQNPHLVPDSSAARTPACSGSSPTVEYLIERVTSTGTPVYLLDATRDDVGVPVVRA
                     IAPGLRPWWSRLADGRLYEVPVALGWRETRMEEQEANPIAMFF"
     gene            complement(13465..14289)
                     /locus_tag="HMPREF9062_RS01550"
                     /old_locus_tag="HMPREF9062_0338"
     CDS             complement(13465..14289)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="HMPREF9062_RS01550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0338"
                     /product="ABC transporter permease"
                     /protein_id="WP_009409868.1"
                     /transl_table=11
                     /translation="MITISAQFRLQCLGFFRNSRSLFFTVAFPIALALLFGIANEHESM
                     PFQGTSTTVEYASWTALGLSAYVLLMGGFVKVAGDIASQRESGLLKRIRLRGSSDAAVL
                     AGYVLAGLLVSIVCLVLLLAASVLFLKLPAPVHPGGVILVGVGGAILCTTIGLAYSAFI
                     PSAEASQMLLLVPTLILMFLSGVFEPDWLVPDTLRDIGSFFPVQYLADAARSQWLGVDL
                     IHSTINGDSVTVGSAQGLSILVGHGLWVCLAWFVVSLVAAARFFRWDARVSR"
     gene            complement(14346..15335)
                     /locus_tag="HMPREF9062_RS01555"
                     /old_locus_tag="HMPREF9062_0339"
     CDS             complement(14346..15335)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="HMPREF9062_RS01555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0339"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_009409869.1"
                     /transl_table=11
                     /translation="MSELALDVHDLAVHYGKFEALKSVDLSVAYGQIVGILGPNGAGKS
                     TLVDALVGAHRKSAGTIRTLGCDPVKEAAALRPRLGVVLQSAGFPPGLRVKDIVRSWRR
                     YTPTVTVDEVNNLVRDVEITRLMNRPLSSLSGGELRRVDITLALVGSPELLILDEPTTG
                     LDPTSRQRVWDVIVRQRDRGATVLLTSHYLEEIEALCDRVFVLRGGVISTSGTPGELAR
                     SIPSPRRCSFRPASGRNVSQLGLSFGEGLESQSDGYWAWSTPTPAADVRELMERAQRTG
                     FEIEDLTVAPATLQAVYSALVGTDADSHQAAPARHHAEHSRQTEEKLS"
     gene            complement(15332..16336)
                     /locus_tag="HMPREF9062_RS01560"
                     /old_locus_tag="HMPREF9062_0340"
     CDS             complement(15332..16336)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022623.4"
                     /locus_tag="HMPREF9062_RS01560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0340"
                     /product="DUF2961 domain-containing protein"
                     /protein_id="WP_009409870.1"
                     /transl_table=11
                     /translation="MTTTVYPHRETRTIIFSDNLPAGRTATIFDVTGPVTTSSINLSVA
                     PYGPVSVRAQRLLVYSDDLTEPAMDVPIADLAGLTHGRVSPMRSRYAESSGSTVTLMWP
                     ISAREHLRMNVVNEFSAPVPFGASIDYRRVCETPYLAAAFTVSKPPFGQPVEISLPKGA
                     RELVGLVVGVQPSDNTSWCGEGRIMLDDQVLADGLDMLAGTSLDVTQWFGSDRGASVAV
                     RMEGSGSGHDLLGIYRWFPHGVVVEEPGRLMIEQLGRIVRVHDGTYTSARAPRSDRWEI
                     VTITTHDAPANVERFEYSAAEAEKLVARRDYEELTAREHLWGRMQQHRAQEPQ"
     gene            complement(16333..17487)
                     /locus_tag="HMPREF9062_RS01565"
                     /old_locus_tag="HMPREF9062_0341"
     CDS             complement(16333..17487)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="HMPREF9062_RS01565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0341"
                     /product="cytochrome P450"
                     /protein_id="WP_172634820.1"
                     /sec_met_domain="p450 (E-value: 1.5e-14, bitscore: 50.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAHNWDIKSPEWYADAPRMWDDLAGVGSAVITVEGTQWTLVGAY
                     EQARSILQDGVSFTSSGERILLETVRGRGGASTKGGGSALPPSLLSFREDKESRGIRKS
                     LRQGLDELPAAFEEDASLFQELETRLAVTECVDLSETALSLSTTSMSLLLGVPAGVTAV
                     YEAWIRDGGRRITDTVLHQRVTAALTDAQSGLMAGLLSRGWSAPDAAWALVWLSRASVR
                     TLARALCNTFQTFSSEPGLPQFLDAGGDVNAAVNEILRLNPPTSALGRLAVGEQEVGGR
                     IVPDGSLVVPVLAAAQRDRSVFPAGAVFRPENDGRPLLAFGWGRHSCLGETVARSLLAV
                     VVAFIRDRRLAFESAGPAVRHPSFCFSSWDRLPTRITRLSRSAG"
     gene            complement(17499..17639)
                     /locus_tag="HMPREF9062_RS12755"
                     /old_locus_tag="HMPREF9062_0342"
     CDS             complement(17499..17639)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF9062_RS12755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF9062_0342"
                     /product="hypothetical protein"
                     /protein_id="WP_009409872.1"
                     /transl_table=11
                     /translation="MTDQELEEDRRYERKRRLKLIRRIVLIGGGIIVFIAFNWTWLVSQ
                     F"
     gene            complement(17686..18012)
                     /locus_tag="HMPREF9062_RS01570"
                     /old_locus_tag="HMPREF9062_0343"
     CDS             complement(17686..18012)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF9062_RS01570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF9062_0343"
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="WP_009409873.1"
                     /transl_table=11
                     /translation="MVDHESQGDVQFDEKALARVMGRAYADDAYREVLTSSPSETLEQA
                     GALASGSIATAALDAELEDWDYAVHHDENGAHLRIGLPDLEEELDTSVPEDGLTVACCC
                     CCPC"
     CDS_motif       complement(17734..18012)
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MVDHESQGDVQFDEKALARVMGRAYADDAYREVLTSSPSETLEQAGALASGSIATAALD
                     AELEDWDYAVHHDENGAHLRIGLPDLEEELDTSV"
                     /locus_tag="HMPREF9062_RS01570_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       complement(17686..17733)
                     /prepeptide="core"
                     /locus_tag="HMPREF9062_RS01570_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type III"
                     /score="-2.90"
                     /molecular_weight="1516.8"
                     /monoisotopic_mass="1515.5"
                     /core_sequence="PEDGLTVACCCCCPC"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MVDHESQGDVQFDEKALARVMGRAYADDAYREVLTSSPSET
                     LEQAGALASGSIATAALDAELEDWDYAVHHDENGAHLRIGLPDLEEELDTSV"
                     /leader_location="[17733:18012](-)"
                     /alternative_weights="1534.8"
     misc_feature    complement(18183..18201)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.11"
                     /tool="antismash"
     gene            complement(18234..19787)
                     /locus_tag="HMPREF9062_RS01575"
                     /old_locus_tag="HMPREF9062_0344"
     CDS             complement(18234..19787)
                     /EC_number="2.7.7.72"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730811.1"
                     /locus_tag="HMPREF9062_RS01575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0344"
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="WP_009748247.1"
                     /transl_table=11
                     /translation="MTDPAASSAPASSSGSSAAPDRAPAPDVVERALLDDPPDAGGLTP
                     AARHALRELPPSLATLGNLFIRAGHELSLVGGPVRDAFLGVMPHDLDCTTSARPEQTEE
                     ILSAWGDACWDVGRNFGTIGARRGGVVVEVTTYRTEEYEVDSRKPAVAYGDTLSGDLTR
                     RDFTVNAMALRLPDLVLVDPHGGLADLRAGVLRTPVSAVQSFDDDPLRMMRAARFSAQL
                     GFDVEMDVMNAMTRMAPRLEIVSVERVRAELERLLVSPWPRRGLELLVHTGLADVVLPE
                     LAALRETVDEHHRHKDVYEHTLTVLDQAMGLETRADGPVPAPDLVLRLAAIMHDVGKPV
                     TRRFLPNGTVTFHGHDHVGARMTKKRLRALRFDKQTIKDVSRLVELHLRFHGYADAGWS
                     DSAVRRYVTDAGELLERLHRLTRADVTTRNKRKARMLDAAYDDLEARIAALRQAEELAA
                     IRPDLDGRQIMDELGIEPGPVVGEAYRFLMDLRMEKGPMGEELARQALRSWWAARDDEG
                     "
     misc_feature    complement(19614..19616)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19856..20365
                     /locus_tag="HMPREF9062_RS01580"
                     /old_locus_tag="HMPREF9062_0345"
     CDS             19856..20365
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009232692.1"
                     /locus_tag="HMPREF9062_RS01580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0345"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_034253505.1"
                     /transl_table=11
                     /translation="MPSHRTRKPRAGAPARRASARPLPVIDETSAGGLVIAVRGGRAVT
                     AVIARRNRGGRLEWCLPKGHLEGSETAEEAAVREIAEETGISGRVLRHLATIDYWFAGD
                     DHRVHKIVHHFLLEALGGWLTTDNDPDHEAEEVEWVDLDDVSRRLAYPNERRIVAAARE
                     ILVGDG"
     gene            20362..22680
                     /locus_tag="HMPREF9062_RS01585"
                     /old_locus_tag="HMPREF9062_0346"
     CDS             20362..22680
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730813.1"
                     /locus_tag="HMPREF9062_RS01585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0346"
                     /product="DUF6049 family protein"
                     /protein_id="WP_253270629.1"
                     /transl_table=11
                     /translation="MNPLRFRSRPRRSPVRLLATVVAAVALLACITGLGTTTAAWAVPA
                     PSTAQDSAEPAAAQMIDGRVTLSIDSLSPEVVGSGQDVTVSGTIANGTDRTLERMSATV
                     QAQNGTEITVTGLKSWLADETDTAMSKVHTGDLGVRVAPGEVQTFSIDLAADDLPFGEA
                     DQWGPRGLQLTLSQGGDLIAQDRTILVWDAGAQASRSHTTTIIPVTASPADMSLLTTGA
                     DPPSRDALADLRTRIASLLALAGDGVVLAVDPALLHALGVTEETLTATTSSASASPSAS
                     GGAGDGGTSSASAPSAQPSQSAQAPPSPSSSSSADPTAAASPSGSTPSAQRSPGQTIAN
                     ALTRALAAGDVVALPWADVDVSALAHLDETDLLSDAATRTGTSEVVEAGAPTSLTWLAG
                     DLDATTLSTLPDSTTTIVTSPGDLPVTADLTYTPSEVTSIGSRTVLTPDEDLSDALGGT
                     LRTGESSTALSDLDATQLLRGETAILTRQAPAISRSVVVTLDRTAAASIDADRLARRLK
                     ALQDSSWTSPQGLKALTAEARAQQDGGTRASREDVPDQIDGDDEVPASDLAAARTSKEY
                     LDSVTSILTDPQTVIGSASEVVERTASAVWRSDPAGRTTMAGSARERGTAVTTRLTAVP
                     SRTINLIAAEANLPVRITSSLDQDATVMVRLRSSSARLQTVEDVTLTVPADGQATATVP
                     VKAVGSGDVDLTIMLLAADGTAVGAPQNVHMRVHADWETRGTRVMGAGLVILLIGGIVR
                     TVRRGRRTATPTPSIEEKT"
     misc_feature    22687..22700
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.27"
                     /tool="antismash"
ORIGIN
        1 catcctcgcc ccgcacctga ccaccctgac caagaaggag ctggggctgc cgcgcttcga
       61 ggacgccacc gagcgccagc gccgcgacgg catgtgcttc aaggatgagg ccgagctcta
      121 caacgacggc aaggccttca aactcgtggc tcgcgacgag cggggcgtca tcgtcaccat
      181 catcgcggac aactactacg gctactgcaa gaaggaggtc aagacccaga tcggctactc
      241 ggccaacctc ttcggctgcg tggaggagga gcactccggc ggcgccctgg cctacccgcg
      301 ctacaacctc ggccaggagt acacagacgc gcacaccccc gcgaacgcca cggtcgagcg
      361 ggtgctggag cgcaaccagg gacgcttcca ggcgcgcgcg gacggttcgg cggtcaagac
      421 cgacgacgac acgatcgtcc tggtgcccgg cggcgcccat ttctcgatgc gcacccagac
      481 gatcacctgg gcccgcgccg acggcggcga ggcctccatc ccgctgctgg tcggcgaggt
      541 ctacgtcacc ccgagcgggt accggatcca cgccaagcac cgtgagggcg acgccaccca
      601 gtggcatctg gtgggcaccg ctccgtgggc cacccaggcg cacaagccgg ccaccgtctc
      661 gggcgggggc aagtcggaga tctccaagtc gctcctggac gccttcgtct tcggcgaggc
      721 ctacgtcggc gacgtggacg ccgatttcga cgccgttcag aagatcctcg acggcgacta
      781 cactcaccgc ttcgtcgaca aggccaatga gagcgcgcac caccgctcca tcctctccga
      841 gcggcgctca ctggggagcg tcatcaagct gttgacgccc tcgagcatgt acacggccga
      901 gtacaacgac ttcctcgcct ccatcccggc ccatgtcaag gagctcatct tcattatcaa
      961 gcgctactac cagccgagct ggggctccga ctggcgcagc catttctcgg tgggcgtggt
     1021 caatggccgc aagtccaacc agctccggct ggacggggag accgtgaagg tcaacatgct
     1081 gcgggtggga ttcgaggatg acggcgcctg gcgtctgctg tccctgcgcc cggatttctc
     1141 accggccgcc aaggtccaga ccgaggacga catcaccgcc tcgatcgtgg cgcccggcgg
     1201 ttcggccgcg acggccgggg cgagtgcatc gcgcaagttc gtcaccaact gcgagtccct
     1261 gctcttccag cgtcccgacg acgccatcgt gcgcggctac gacaagcaga ccgagaagga
     1321 catgtccggt gagtcggaca cggacctgtt catctccaac tttcagccgt tgactcccga
     1381 cgacgcccgc gccatggtcg ccgacgcccc cggtctgtcc cgcttcaccg agcccatgca
     1441 gaacctcgtg cgccgcgcgg ccgccctccc cgaggccgac gacccgcgcc aggagatcta
     1501 ctggacctcg acggccaacc cgcgcctggt cggcggcgcg ccgactaaga acccgcgcta
     1561 cctgcagatc cgcccggata tcgctcaccc cgaggacgtc gcgctggccg acctgtcctc
     1621 ccacctgtac cgcaacacgc cgctgaccga gccggcgcgc cacagcgtcg acgtcgtcgc
     1681 cgcggggcgc cgcaacaatc cgcccgaacc gggcgtgccc gcactgtgcg cctacaaccc
     1741 cctgcactac atggagccgc ccgagctgtt catggagttc atctcctcca tgaccggcaa
     1801 atcgccctcg acgacgggcg ccggcagcga gggggcgctg accaagtcgc cgttcaacgc
     1861 gctgccgccc gtctacgatc tcaacgcctc gctgctgtcc tacgcgctgg ggggctacga
     1921 cggctggctg tcctcggccg gttacatcgg cccgaaggtc aaggtcgccc atgacatctc
     1981 gctgctcgtg ccggagatct tctcgcgtat gacacctcgg gagcgcgacg cgcgcaccct
     2041 tatcgaggcc ggtttcctcc agcgcctgga ggacttcgat tacgagggcc gccgcatcga
     2101 ggcctcgcgg ctgggctacc gcatgaacga ggccttcgca gcgacgtact tcgggcgcat
     2161 cttcctgcac cccgacgtcg tgttcaccga ggagatgctg agacccgagc tgcaggatcc
     2221 ggggatcttc gccgactccg tggaggtcat cgtggccacc caccagaccg tggcgaagca
     2281 ctacgtcgac gacggttcca tccagtgggc cgtcccgccg ctgcgggcgc tgctggagat
     2341 catgtactcg gggcgctcgg cggagggctg gacgctggcg agtccggagt tccgcgccct
     2401 gttcgaacgg gagaacattc tggcctccga ctggtacgcg gcgcgcgtgg atgccaaggt
     2461 ggagcgggac cgcaagcagg ccgaggcctc gatccgggcg ctcactcgct tcaccaccac
     2521 ccagggcaat gacgaggtca ccacccgcct ggacatcgag ggacgtctga gcgcggcgcg
     2581 cgcttggctc gatagggtcg cctcaccggc ctaccgcgcg catctggtcg gcacgctcgg
     2641 cctccagccc gccctggccg agggcgcgcc gatcgacgtc gcctgacgcc gcccggccgg
     2701 tctccccgcc gagatcggct tttcgggctg agggtgacga cggcgtcgtc accctcagcc
     2761 cgaaaagccg acttcgatcc gaaatgtcga tttcgattcg aggctccgcg ccggtcactc
     2821 ccaacacgca ttcgccgggt ccaccccatg agccgcggcg ttggcgtcga tgacctcctt
     2881 gagccaggcg gtcaggcctg cctcgtgacc gtcgtagaac tcggtgaagc gcgggtccgc
     2941 cacgtagccg cgggcgatga gcacctgctt ggagtgggtc gtgtcgaacc actgatcgat
     3001 gctggcccgg tgctgctcgg cgagctcgtt ggcgcgcctt gagccgggct tcacgccctc
     3061 gcgcttggca tcgaccagag cggtgatgag ctggaggctc tcctgtgcga cgcgtgccca
     3121 gtcctcctgc gtcatggccg ccttgcgagc ctcggactgg gcccactcat cggtgccgcc
     3181 ccagcgctcc tccgcctcct cgcgccactg ctcgccccag tcggtaccga agatcgacgc
     3241 ccgccgcgcg gcagtcaggt cggtctcatt catggtttcc tccatcatcg tgtccacagc
     3301 ccggagcatc cgggtcaggt gggcgatgca atccgtcaga agctcgcgct ggcgtgccag
     3361 gtgggcacga gggtcgacgt cggggctatc gaggatccgg gcgatctcgg ccaggctcat
     3421 cccggtctcc cggtagacga gcacttgatg gatccgggcg acgtcgtcgg tgtcgtagag
     3481 ccgataaccg gcccaggacc gggtcgacgg tctcaccagg ccgatctcgt cccagtgatg
     3541 cagggtgcgc acgctgacgc cgaccagtct cgcggtccgg ccgaccgtca gcccatcggc
     3601 atcgtccgcg ggctcgcccc gcgtcgtcgt gctcctcacc gtcccagcat cgctcacgac
     3661 gatcagattt gtccctcacg ccgcgtgagg gtcaaacgat cgcggcgccg ccacgcacga
     3721 gcccgcgccg ctccacgcga gtgcgccccg gccccgaccg accggtccga cgttcacagg
     3781 aacttgccag gtcgtacagg ggcgagctcc cagccgaacc gggttacatg attcctgccg
     3841 ccggacggag ccggccgcga gggttgggga acccgacgac cggctggtgt ccgagacgga
     3901 ccgggtctta gggagcccgg ttcggtcgct ccggcgaagg aggagcactc ccccgggact
     3961 gggaacccgg cggcgagtcc ctcgacgacg aaggcccgcg ggccgggaga gacaacccgg
     4021 tgccgcgggc cgcagtcgtg cccgggccct cgctgcacgg tctcggccat cgtcacaccg
     4081 caggaacgtc gcgcggcccc ccgccgagcc ggcgcacggc gcaccggtag ccggccgcca
     4141 ccatccatac gacgaccacc agcaccgcct gaaccgtccg cgaccagccg acgtcgggga
     4201 gcacgagcac ggatacgccc gcggccaggc attcggccga gttgaacagg acgtcgtaga
     4261 tggagaaggc gcggccgcgg aaggcgtcgg cggtgtcggc ctgcacaatc gtgtcaacgg
     4321 cgatcttggc gccctgcaca ccgacgccga acacgaagag tcccgccgtc atcgcggtga
     4381 ccgagtgcgt caccaccagg acgatctgac ccacggttcc gccgatcagg cacatgacga
     4441 cccaggtcgg gggcgtcacc cgctcatgag ccagcggggt gagcacgacc gccagcccgt
     4501 ggccggccac catcgccccc atgagggtgc cgaagagggc cagaccgacg tcggcgttct
     4561 cgggtgccgc gagcagattc ctcgccgcca gaatgagcgt gatgagctcc atgccgtaga
     4621 cgaagcggtg cagggccatg gtgatcaggg ccaggccggg tgtgccgcgg cgtatgagat
     4681 agcggacggc ggcggcaagg tcgtcggcgg tcgcggccag cgcgggggcc aggcccgtgc
     4741 tgcggtcaac ccgctcgggc cccagctcgt cccggcccag gcgcgtgacg accccggccg
     4801 cgagcgtgta cagcgcgacg gcggcgacga ggctcgccgt gtcctgggct ccctcgggca
     4861 gtgtcaggcg catgagaatg ccgagcacgg cacccattgc gctggccgcg ccgcccagag
     4921 tcggcacgat ggaattggcc accagcaggc gctcgtggtc gatgatctgc ggcagcccgg
     4981 ccgataggac ggacagcagg aaacggttga cgcccagggc gatgagaacg agggcgtaga
     5041 cgggcggtcc gattcccacg gtactcaggc acagcgcggt ggctccgatg aggccggccc
     5101 gtacgaggtt gccgaccagg agggtctggc gccgccgcca gcggtcgatg aaagggccgg
     5161 tgaaggggcc gacgacggag aagggaagca gcatgacgac cagcgcggca gcgaccccgg
     5221 ccgcgtcggt catgttctgc ggccggaaga agaagagcgt cgccagcccc gcctggacca
     5281 tgccgtcgcc ggtctgggag acgaggcgga cgccgagcag ggcgcggaag gccgggacag
     5341 tggcgagatc cttgaggtca gcggtcaggc gcatggtgca agactgacgc acctgttcga
     5401 aggcggccta agcggcgccg tgtgacatcg ggcgacggcg gtgtccgcgg ccgctcggtg
     5461 ccccgccgtg aggtcggccc cgctcgccct cgagcacgac cgcgccccgg tcgggcccga
     5521 tgacggggcg gctcggccgg tcgccccgac ccgctcacag cgggtagcgg gagccgccgc
     5581 cgagcaccgc gtcggtcagg tcgaccttgc gcccgtcgag tcggaaccgg tagcgaccgg
     5641 tcaggtcgac gtcctcgtga ccggcgacga aggcgcgcac agcgtccttc tcccgcgcat
     5701 ccagccacgc ggggcggtcg gacaggcagc ggaagcggca tgccgcggcg agttcctgga
     5761 gccagcgcat ctgctcgtcg ctgagcaggt tgcgccggtg ccggaagaag acgacgtcgg
     5821 ggtcgatgcc gatgacctcg cccagccaca atcggttgat gctggtgcgc agggcgttga
     5881 gggccatggc atcggacggg tcgtcggtgg cgtagttgtc ccacatgggg gcggcgtcgg
     5941 ggccgatccg gacggcgtcg aggagcccga tcgagggcat cacaggggcg ccggaaccga
     6001 ggaggaaggc ctcctcgccc gcggctcggc ggacgacccc gataccgcgc cggtaggcgt
     6061 gctcccggtc gatctcctcg tggcggcgac cgggaatcgc cgcggcgttg atgaagtcca
     6121 acttgaggta gccgaagccc cactcgtgaa cggcccgcgc gaccgtctca tgcacgacgt
     6181 cgcacgcctc gggccgggtc aggtccaggg catggtaggt ggtgccccag ttggagccgg
     6241 ccacagccgg ggcgccgtcg ggaccggtca cgaagagctc gggccgggtg gccgcaaggc
     6301 gagaacccga cagggcgatg aagggcgcca gccacaaccc gggctccatg cccgcccggc
     6361 ggatgcgggt ggcgatatgg gccatgccgt cggggaagcg ctcgccgggc gcccagtccc
     6421 cgacggcggc ctcccagccg tcgtcgatct gcagggtgtc gacccccagg gaggcgatgg
     6481 cgtccagctc gtcctccagg gccgcctgcg agacgtcctc gtagtaggag taccaggagc
     6541 accacacgct gcgcggccta atcgggcggc gtcccaggtg ccggcccgcg gcgcgggcgt
     6601 aggcgaccag gacctcggtg acggtcccga cccggatcat ccactcggcc cggcttcccg
     6661 tctcggtcag ggcctcgagg gcggcggtgt cggcgcgtac gcgcggtgtg tctccctcga
     6721 ggcagccgac cagaagggcc cgtccgtcct cctcgccgct cctgtcgtcc tcggcgagaa
     6781 cggtcagcca ggcgctgtga tggcggacag ggtcgtccca gatatcgtcg tcggcggtgc
     6841 gccggcgcgc cggatcggag atcctcatgg ggctctcgcc gaggcggcgc catcccgcgg
     6901 gggaccagga gttctggccg gtgcggtaga ccagcgcatc gggcatgtcg tgcaggacgg
     6961 tcaggcggcc ggcggacacg atcgcttccg cgccggtcgt gctcacgacc ggaccatcgc
     7021 aggcgatggc cagacgccac cctgcgaact cgaggtgatg aatcataccg gcatccttcc
     7081 agcccggcga tgcggtgtca gcccggactc ggagcgggcg ggccggcctc gaccggcgag
     7141 tccggctcag gcggcggata tgagacgcgc cgacagaacg ccgtcgatac cgcgcagctc
     7201 ctccagggtc gggagctcga cctcaccctc gacgtcgacc agggtgacgg cgagttcgcc
     7261 gcgagagcgg ttgagcaggt tggcgatgtt ctcaccgtgc tgggcgacga tcgtggagac
     7321 ctggccgacc atgttgggca cgttgcggtt gacgatgagc acgcggtgcg tgccctcctc
     7381 ccggggcatg acagcctcgg ggaagttgac ggagttgtgg acctgtccgt cctcgaggaa
     7441 gccgcgcagc tcgtcgacgg ccatgatcgc gcaattgctc tcggcctccc tggtggaggc
     7501 gcccaagtgc ggtagggaga tgcactttgg gtgcttgtgc acgttcgtgg aggggaagtc
     7561 gcagacgtag ccgcgcaggg catcggcgtc gagggcggag atgacggcgc cctcgtcgac
     7621 gatctcggcg cgcgcgaaat tgaggatgac ggctgagtcc ttcatgagcg cgatgcgctg
     7681 ggtggatacc aggccgcgag tcgcctcgat gagggggacg tgaacggtga ggatgtcagc
     7741 ccgcctgaag acatcctcga tggactcggc gcgctcgacc tcggcgctca gatgccaggc
     7801 gtgctcgacg ctgatgcccg ggtcgaaacc gacgacgctc agccccaggc cgagggcggc
     7861 gttggcgacc tggacgccga tggcccccag gccgatgacg cccagggtgc ggccgggcag
     7921 ctcgaaaccg atgaactgct tcttaccggc ctcgacggcc ctggcgatgg cggcgtcgtc
     7981 gccctcgagg gtatgggcga aacgcgcggc ggggatgagg ttgcgcgagg cgatgaacag
     8041 gcccgccagc acaagctctt tgacggcgtt ggcgttagcg ccgggcgtgt tgaacacggg
     8101 cacgccgcgc tcggtcatgt cagccaccgg gatgttgttg gtgccggcgc cggcgcgggc
     8161 gacggccagg acggagtcgg ggatcggggt gtcgtggagc ttggccgagc gcacgaggag
     8221 ggcgtcgggg tcggccaagg aggcgccgac gtcgtagaga tcgtcgggga agcgggacag
     8281 gccggcgcct gagatggcgt tgaaggtctg gacgcggaac tgcttacggg tcgtcatgag
     8341 ggtccttcgc tgaggtgcgc ggtggttggc tcgtgctcgt aggggcgatg ggatcggtcg
     8401 gcggctgtcg acggggcgac ggcgtaacgg catcggcggt caagcggagg ccgccgcgca
     8461 ccggccggcg ccggacgtcg ggcatcctca agcgcgggtg cgctcgaact cgaccatgta
     8521 gtcgataagg gcctggacgc cctcgatggg catggcgttg tagatggagg cgcgcatgcc
     8581 gccgacgctg cggtgcccct ggaggttggt caggcccgcg gactcggcgc cggcgaggaa
     8641 gtcggcatcg agtgacgagt cggccagggt gaagggaatg ttcatccggg aacgggagcg
     8701 ctcctcgacc ggattggtgt agaagtccga ggcatcgatg gcccgataca gacgcgcggc
     8761 cttcgcccgg ttgcgctcgc ccatggcggc caggccgccg gtggactcga tccagtgggc
     8821 gatcaggtcg agcaagtaga cggagaaggt ggggggcgtg ttgagcatgg agtccttgtt
     8881 cgccatgacc ttccagtccc agatggcggg gacgtccggg cgggcccggt cgaggaggtc
     8941 ctcgcggacg aggacgacgg ccagccccgc cgggcccagg ttcttctgag cgccgccgta
     9001 gacgacgccg aacctggaga tgtcgatggg gcgcgagaag taggcggagg acatgtcggc
     9061 gacgagcggg acgtcgccgg cgtcgggaat gtcggggtac tcgacgccgc cgatggtctc
     9121 gttgggggtg tagtggaggt agacggcgtc ggcggggacg acgaaggagc ccggaccggg
     9181 agtggtggtg taggaggagg ccgcttcgtc ggcgatcacg tcgacggcga cgccctgacg
     9241 ccgagcctcc ttgatggctt tggccgacca ctggccggta ttgaggaagg cgaccctctc
     9301 accgcgggcg gcgaggttgg cggggacggc ggtgaactgg ccggtggcgc caccggccag
     9361 gaagaggatc ttgtagttgt cgggaatgct cgcaaccgag cgcagggcgg cctcggcgtc
     9421 ggcggcgcac tcgacgaagt ccttcccgcg gtgggagacc tcgagcacac tcatcccgga
     9481 tcctcgccag tccgtgagct cggaggcagc ctgctccagg acgggcaggg ggagctgagc
     9541 gggtccggcg gagaagttgt acacgcgcat ggcgacacga taccgggacg atcgggatct
     9601 catccacggg tgagtgccac gggccacccg cgtctgctcc gcaccttcgc ctcccgctgg
     9661 acgcctccag ggaacgaggt aagaaggcat gaagcgagtg tggatgcggc tacccggctc
     9721 cggaccgccc ctgcagccgc agatcccgac gtcgtcggct cgctcgcacc acctgggcgg
     9781 gaagagtccc tcatccgaac ccactcacga tgcgcacctc atcctcggtg gactccggcg
     9841 cctcaagcac gccatgttcc tgtccgcctt cgcctccctg taccccgatc ctctctcacg
     9901 gccgcggcac cgtcctcaac cgccctgctg cgcgctgcgc agcggaaagg agcggatcct
     9961 gttcatgtca cgatgcactc gcgcggcggt catgctccgc tcattccgcg cggccggcca
    10021 cgatcatctc gccgaccgcc accgcgcgcg tcgggtcgtc gatgtcggca ccgcacaggc
    10081 gcggcagaac gtctccggga cctcctccca aggcgcacac gccgagatcg gagtcctccg
    10141 cgcacaagta catggtctgc atccaggcac cgacgtgctt gaggatcagc gctggaccga
    10201 ccgactcgta cttcgccagc actcgggcgg cgtcggcgag gaccacgacc acgtactgca
    10261 gctcatcggc cgccactccg gcgatttgcg agtatgtgcg caccgtctcc cgcacgccga
    10321 ccggatccgt ggtcagctcg ctgagggtcg agcggagcgg ggagtattcg aaggcgcggc
    10381 cggacagggg ctcgccatgg tgcgagccgc gattggcgat gatgacgaag tccagctcac
    10441 cgagcgaccc gccgcagggg tacgggaagc ggaacaggtg ttcgccctgg ggtcccgtgc
    10501 cgattcttgc tccgatggcc gagcgggcca gaacctgtac gacgtcggac agttcagcgg
    10561 ggtcacccgc gtgctcccgt ctgctccggc gttcgccgag tgccgctgac aggctcaacc
    10621 cgtcgtcggg gtactcgacg ttcaccgtct cctcccgggt gcccgcgcgc acgacgggcc
    10681 tgcgaacggt cggcatgccc ccgtgcgttt tagaccggcg gtaggttcct ccgtacgcgc
    10741 ccacgtgggt gccggcccga gaacggatca gcggcagggc ctcgtcgaaa gaccaccagt
    10801 cgtccgcggg gtcggtgagg gcggtggacg cgcccgcatg tgccagcagt ctcagcgctg
    10861 tgaaggcgga cagcacaccc tcgggagcgg agtccggggc catgagatac gacgccccgg
    10921 gagaactcat atgaacgacg gcgcgcgtcg acaggcatgc cacgatgaac gcgccatggc
    10981 gggggcgcat gtagacgtcc gggctggctt ccagtccgga ggcgtcgatg tccggcgcgc
    11041 tgtcgagcag ggcgtgcgga cccgtgaccg tggcaatgac atcgtctcca accgatatac
    11101 gggagcggac ccgccccgtc ccggccaggc gcgtcaaccg accgtagcgc atggagtact
    11161 cggcgggagt caggccttca cccagagttc tgaggtccag ccattctccc ccatcgggat
    11221 tctccacctc aagggcgaca tccgggtcag aagaacattg caatcggatt cgcctcctgc
    11281 tcctccatcc tcgtctcccg ccagccgagt gcgaccggca cctcgtagag gcggccatcg
    11341 gcgagcctgg accaccaggg acgcagtcct ggcgcgatcg cgcggacgac gggtactccg
    11401 acgtcgtccc gcgtcgcgtc gaggaggtag acgggggtac cggtgctggt gacccgctct
    11461 atcaggtact cgacagtggg cgatgaacca ctgcacgcgg gggtgcgcgc agcggaggag
    11521 tcgggcacca ggtgcgggtt ctgcgcgagt ctcgcacggg tgagccactc gatggcctcg
    11581 cctcccgacg gccggccggc gtcgggccga tgccagacct ccggcggtat tgacgcgcgg
    11641 aactgcagca cctcggcgac ggccctgacc gcggcctggc ggacgtcggt atgcgctccg
    11701 aatccgagga ggatctggtc gcaggctccc ccgtcccggg cggggctgac cgctcccacc
    11761 acggggaccc cgatatccgt cgtcagatcc agaagccaca ggtcccgctc cagagtatcg
    11821 agccatcgct tagtggaacg gaggtagtcg tcgtccaggg attcgaggtc gacggcgggc
    11881 ctgcgaacgc ggttgtacca ccacagcgcg acggcgtccc gctcgatcag ctcggcgagg
    11941 ccctggaagg cggcgtccgc cctggtggcc ccggccgcgt acccgttcga gtcggccctg
    12001 gcgaatcgcc ggcctacgcc atccacggag cccggggagg ccgcggcgtt cgggaacatg
    12061 aaatagcaca gtgcggtcag catccaggcc gtggatccgt ccaccgggtt ccacacgggc
    12121 gtgaagtcga ccagtgcatt ctcctcgaag ggctcgggga tgtagttgta gaggtcgttg
    12181 gccctgttcc gctcctcccg actcgcgaac tgtcgatcgg agaacagctg gacggcgttc
    12241 gggtgcacag cggaaggcag atcggtgaag cgggcgcgcc ttcggcgctc tcggcccact
    12301 gcgatggcgc tgtgccgctc gacggcttcc gccagtccac cggcccgggc ctgcgcatca
    12361 gttctgccct tgccccccga ctggcctcgc aggctccttc gcaggacggc cggatcatct
    12421 gtgcgcagtg cccagttatg ccccgctacg tagacgtgag ctggactgtc cggatcgttc
    12481 ggatcatcga ggcgctccag ttcgcggact acaccggtga cgtcggacag gaggtgcgca
    12541 ttgcgctcga ggaagtccgc ggtggacacg gagcgtccga tggcatcggt tcctctcgtg
    12601 cgcaggtcga gtggaatcgc ctctgtcgcg ggcgcgacat cctgggagtg cggctgacga
    12661 cgaatagggt ggaccctgcg acccgatccg atctcgacca actcaataat ggcttcttcg
    12721 gctcggcagt gtcctctcgt gaaccactcg tccagctgct cgcgcatggt gagagcgaag
    12781 ggggtggcgg tctttcggat gcgatccagc ggcaggggag agcgcaggac gcttccgccg
    12841 atctgcgccg ccctgtcgtt gaaacgcaac gcgaagatca ggtcgtcgag gacgcccgac
    12901 cccgcgggcg cgaacggtcc gacgaagagt cggttgtcga cgagtgcgcc gaatgcgacg
    12961 gcatcgccgc gtgctcccgc ctcatcgagg gcgcgccggc aggcccgtgc cttgtagtcg
    13021 tcgaccagga cgatgtcgac attgattccc ggttggagac cgacgagcgc gcgggagagc
    13081 gctgcgacaa ggtcctgcga tccgagcagg tcgatgacgt gagttcgtcg ggggaacgac
    13141 gatgcgtccg ggaagcggtc gcccaaccgg gcgaccgggt attcgtcgac gagaataccg
    13201 aggcgcctga ggagttccac cgcaccgtag gcggcggcca ggggcattgt gtcaccactg
    13261 atcaggtcgt gcatttcgcc ggtgagacag gcccgcagaa tccgggcggc gtctcccttg
    13321 atctcacgaa gatcatgatc ggccaggacg gcgatactgc gctccgagtt ccgttcgacg
    13381 tatctgtaac gcggattcgg catcaccgcg aagtcgtcgc tctcggagaa cgcctcggtg
    13441 ctcgctacgg cgttcgtcat ggcatcaacg gctcacacgg gcgtcccagc ggaagaaacg
    13501 agccgctgca acaagcgaga cgacgaacca ggcgaggcag acccacaagc cgtgtccgac
    13561 gaggatcgat agcccctgag cgctgccgac ggtcaccgag tccccattga tggtggaatg
    13621 aatgagatcg acccccagcc actgcgaacg ggcggcgtcg gccaggtact gcaccgggaa
    13681 gaagctgccg atgtcccgca gcgtatcggg taccagccag tcgggctcga agacgccgga
    13741 taggaacatg aggatcagcg tgggtacgag gagaagcatc tgggacgcct ctgccgaagg
    13801 gatgaacgcg gagtaggcga gcccgatggt ggtgcatagg atcgcacctc ccactccgac
    13861 caggatcacg ccgccgggat gcacgggtgc gggaagtttc aggaagagga ccgaggccgc
    13921 caggaggagg acgagacaca cgatcgagac cagcagaccc gcgagtacgt agcccgccag
    13981 cacagcagca tccgaggagc cgcgcagacg gatgcgcttg agcagtccgg actcgcgctg
    14041 cgaggcgata tcgccggcga ccttgacgaa accgcccatg agcaggacgt aggcactgag
    14101 ccccagggcg gtccaactgg cgtactcgac cgtcgtgctc gtcccctgga acggcatgga
    14161 ctcgtgctca ttggcaatac cgaagagtag agccagcgcg atggggaaag ccactgtgaa
    14221 gaacagcgaa cgggagttcc tgaagaatcc caggcattga agtctgaatt gggctgatat
    14281 ggtgatcatg aatgatcgcg gcgacgaatg cgctggagcc ggacggcgat gctgcgtcgt
    14341 tgtcgtcatg agagcttctc ctcggtctgc cgagagtgtt ccgcatggtg ccgcgcgggg
    14401 gcggcctggt gggagtccgc gtccgtaccc acgagtgcgc tgtacacggc ctggagggtc
    14461 gccggcgcca ctgtgaggtc ctcgatctcg aatccggtcc gttgcgcacg ctccatgagc
    14521 tcacgcacgt ccgccgccgg cgtcggggtg ctccaggccc agtagccgtc gctctgcgac
    14581 tcgaggccct ccccgaagga aagtccgagt tgcgagacat tccgtccgga agccggccgg
    14641 aaggagcagc gacgaggcga cgggatcgat cgagccaact ctccgggagt tcccgaggtg
    14701 ctgatcaccc ctccgcgaag aacgaagacc cgatcgcaca gcgcctcgat ctcttccaga
    14761 tagtgactgg tcaggaggac agtcgcgccg cggtcccgct gacgcacgat cacgtcccac
    14821 acgcgctgac gtgacgtcgg gtccaatccc gtggtcggct cgtcgaggat caagagctca
    14881 ggactcccga ccagcgccag ggtgatgtcc acacggcgca gctcaccgcc ggacagcgag
    14941 gacagcggtc gattcatcag ccgagtgatc tccacatccc gcacgaggtt attcacctcg
    15001 tcgaccgtca cggtcggcgt atagcgcctc catgaacgca cgatgtcctt gaccctgagg
    15061 cccggcggga atcccgcgct ctgcagcacc acgcccagac gagggcgcag cgccgccgcc
    15121 tccttcacgg ggtcgcagcc cagcgtccga atcgttcccg cggacttgcg gtgcgcaccc
    15181 acaagcgcgt cgaccagcgt cgatttaccc gcaccgttcg gcccgagaat accgacgatc
    15241 tgtccatagg cgacactgag atcgacgctt ttaagcgcct cgaacttgcc gtaatgcacg
    15301 gccaggtcgt ggacgtccag tgccaattca ctcattgagg ctcctgagct cggtgttgtt
    15361 gcatacggcc ccacaggtgc tcgcgggcgg tcagctcctc gtagtccctc cgcgccacca
    15421 gtttctcggc ctcggcggcg gagtattcga agcgttcgac gttcgcaggg gcgtcgtgag
    15481 tcgtgatcgt gacgatctcc caacggtctg agcgcggagc cctcgctgac gtataggtcc
    15541 cgtcgtgcac ccggacgatg cggccgagct gttcgatcat cagtcgcccc ggctcctcca
    15601 ccacgacacc gtgggggaac cagcggtaaa tcccgaggag gtcgtgcccg ctcccggacc
    15661 cctccatccg gacggcgacc gacgcccccc tgtccgatcc gaaccactgc gtcacgtcca
    15721 acgacgttcc ggccagcata tcgaggccat cggcgagcac ctgatcatcc agcatgatgc
    15781 ggccctcccc gcaccagctc gtattgtcgg agggctgtac gccgacgacg agtcccacga
    15841 gttctcgggc ccccttgggc agggagatct caacgggttg gccgaagggg ggcttggaga
    15901 cggtgaacgc cgctgcgaga tagggagtct cgcacacgcg acggtagtcg atggaggctc
    15961 cgaagggaac gggagccgag aactcgttga cgacattcat ccgcaggtgc tcccgagcgg
    16021 agatcggcca catgagcgtc acggttgacc ccgagctctc cgcatatcgg gaccgcatcg
    16081 gggacactcg gccatgggtg agaccggcga gatcggcaat gggtacgtcc atcgccggct
    16141 cagtaagatc gtcggagtac acgaggagcc tttgcgcgcg caccgatacg ggtccgtacg
    16201 gcgccaccga cagattgata ctgctggtcg tgacggggcc ggtgacatcg aagatggtcg
    16261 cggttcgccc tgccggcagg ttgtccgaga aaatgatcgt acgcgtttcc cgatgcggat
    16321 aaacggtggt ggtcaacctg cactccgaga aaggcgggtg attctcgtcg gaagccgatc
    16381 ccacgacgag aagcagaacg aggggtggcg caccgccgga cccgctgact cgaatgcgag
    16441 acgacgatcg cgtatgaagg ccacgacgac tgccagaaga ctgcgcgcaa cagtctcacc
    16501 aaggcagctg tgccgacccc agccgaaggc gagcagcggc cggccgtcgt tctcgggtcg
    16561 gaacacggct cccgcgggga agaccgagcg atctcgctga gccgccgcga ggactggtac
    16621 gacgagactc ccgtcgggga cgatgcgacc gccgacctcc tgctcaccga cggcaagacg
    16681 accgagagcc gacgtcggcg gattcaggcg cagaatctca ttcacagcgg cgttcacgtc
    16741 gccgcccgca tccaggaact gcggcaggcc gggctcggag gagaacgtct ggaaggtatt
    16801 gcacagggct cgcgccaatg ttcgcacgga ggcgcgagag agccacacga gagcccacgc
    16861 cgcgtcgggg gccgaccatc cgcgggagag gagacccgcc atcaatccgg actgcgcatc
    16921 ggtcagagcg gcagtcacac gctgatggag cacggtgtcg gtgatacgac gaccgccgtc
    16981 acgaatccac gcctcgtaca cggcggtcac acccgcggga acgccgagga gcaacgacat
    17041 cgacgtcgtc gacaacgaca gggccgtctc ggacagatcg acgcactccg tcacagcgag
    17101 ccgggtctcg agctcttgga agagggaggc gtcctcctcg aaggccgcag ggagctcgtc
    17161 cagaccctga cgaagggact tacggatgcc gcgggactcc ttgtcctctc ggaatgagag
    17221 aagggacggc ggaagggcgc tgccgcctcc cttggtgctg gcgccgcccc gaccgcgcac
    17281 agtttcgaga aggatgcgtt caccactgga ggtgaaactc acgccgtcct gaagtatgga
    17341 acgtgcttgc tcataagcgc ccaccagcgt ccattgagtg ccctccacag tgatgacagc
    17401 actgccgaca cctgcgagat cgtcccacat cctcggtgcg tccgcgtacc attcgggact
    17461 cttaatatcc cagttatgtg caaccacgga tgcgttcgtc aaaattggct caccaaccac
    17521 gtccagttga aggcgatgaa cacgatgatt ccgcctccga tcaggacgat ccgtctgatc
    17581 agcttcagtc gtcgcttacg ttcgtaacgc cggtcctctt ccagttcctg atcggtcaca
    17641 gggctgtcct atcgagaaat tgcgggctga aacggcacaa tcgtgtcagc aggggcagca
    17701 gcaacagcag gcgacggtca aaccatcctc cggaacggag gtgtcgagct cctcctccag
    17761 atcgggcaga ccgatgcgca gatgcgcacc gttctcatcg tgatgcacgg cgtagtccca
    17821 atcctcgagt tcggcatcca gggccgccgt cgcaatagag ccactcgcga gtgcacccgc
    17881 ctgctcgagt gtctccgagg gagaggaggt cagaacctcg cggtacgcat cgtccgcata
    17941 agcccggccc atgacgcgag ccagggcctt ctcatcgaac tgaacatcgc cctgggactc
    18001 atgatcgacc attgttcttc cttacgcact aggggtcagg gtctaagaag cgtcgacgcg
    18061 atcaacgggt gcagtgtatg tgaaaaaccg acgtgcgtca acgcctcgtc cgcacgtgat
    18121 cgcttcggct cgtcctgcat cgcgaaagaa gcaggatact gacctcaagg tcgaaaagcg
    18181 cagctgcaag ccgctcgcat cttggccttc cgggcgcacg gccgctcgca ccctcacccc
    18241 tcgtcgtcgc gcgccgccca ccacgagcgc agcgcctgac gcgccagctc ctcgcccatc
    18301 ggccccttct ccatgcgcag atccatgagg aagcggtagg cctcgcccac caccggcccc
    18361 ggctcgatgc cgagctcatc catgatttgc cggccgtcca gatccgggcg gatggccgcc
    18421 agttcctcgg cttgacgcag cgccgcgatc cgcgcttcga gatcgtcgta ggcggcgtcg
    18481 agcatgcggg ctttgcgctt gttgcgcgtg gtcacatccg cgcgggtgag ccgatggagc
    18541 cgctcaagca gctctccggc gtcggtcacg tagcgccgta ccgctgagtc cgaccagccc
    18601 gcatcggcgt acccgtggaa gcgcagatgc agctcgacca gtcgagagac gtctttgatg
    18661 gtctgcttgt cgaagcgcag cgcgcgcaac cgcttcttcg tcatgcgcgc ccccacatgg
    18721 tcgtgaccgt ggaaggtcac ggtgccgttg ggcaggaatc gccgcgtgac cggcttgcca
    18781 acgtcgtgca tgatcgcggc cagacgcagc acgaggtcgg gggcgggcac cgggccgtcg
    18841 gccctcgtct ccaggcccat ggcctggtcg aggacggtca gggtgtgctc atagacgtcc
    18901 ttatggcgat ggtgctcatc gaccgtctcc cgcagggcgg ccagctcggg cagaacgacg
    18961 tcggccagcc cggtgtgcac caggagctcg agcccgcgcc gcggccacgg cgagaccagc
    19021 aggcgctcca gctcggcgcg cacgcgctcg accgaaacga tctccaggcg cggagccatc
    19081 cgagtcatgg cattcataac gtccatctcg acgtcgaaac ccagctgagc ggagaagcgc
    19141 gcggcccgca tcatgcgcag cggatcgtcg tcgaaggact gcacggcgct cacgggcgtg
    19201 cgcagcaccc cggcgcgcag atcggccagg cccccgtggg ggtcgacgag cacgaggtcg
    19261 ggcagccgca gcgccatcgc gttgacggtg aagtcgcggc gggtgagatc accggacaga
    19321 gtgtccccgt aggccacagc cggcttgcgc gagtcgacct cgtactcctc agtgcggtaa
    19381 gtcgtgacct cgacgacgac accgcctctg cgtgccccga tcgtgccgaa gttcctgccg
    19441 acgtcccagc aggcgtcgcc ccacgcgctc aggatctcct cggtctgctc cggtcgggcc
    19501 gaggtcgtgc agtccagatc gtggggcatg acacccaaga acgcgtcacg tacgggtccg
    19561 cccacgaggg agagctcgtg cccggcgcga atgaacagat tccccagggt cgctaacgac
    19621 ggcggcagct cacgcagcgc atgacgggcg gccggcgtca gaccgccggc gtcgggagga
    19681 tcgtcgagga gcgcgcgctc cacgacatcg ggggcgggag cccggtccgg cgcggcggac
    19741 gaaccggaag aggaggcagg ggcggaggag gcggcggggt cagtcatcgg tccaagcctg
    19801 ccacgcggaa ccttcgacgg ccgacccact cagccgaacc gcctagagtg tccctatgcc
    19861 gtctcaccgc actcgcaagc cccgcgccgg cgcgccggcg cggcgcgcga gtgcgcgtcc
    19921 gctaccggtc atcgacgaga ccagtgcggg cggactggtg atcgccgttc gggggggccg
    19981 cgcggtcacc gcggtcatcg cgcgccgcaa tcgcggcggc cgtctcgagt ggtgcctgcc
    20041 caagggccac ctcgagggat cggaaaccgc tgaggaggcg gccgtgcgcg agatcgccga
    20101 ggagacgggc atctccggtc gggttctgcg tcacctggcc accatcgact actggttcgc
    20161 gggggacgac caccgcgttc acaagatcgt ccaccacttc ctgctcgaag cgctcggagg
    20221 ttggctcacc acggacaacg accccgacca tgaggccgag gaggtcgaat gggtggacct
    20281 cgacgacgtc tcccgccgtc tggcctaccc caatgagcgg cgcatcgtgg ccgccgcccg
    20341 tgagattctc gtgggggacg ggtgaacccg ctcaggttcc gctctcgtcc tcgtcgctcc
    20401 ccggtgcgcc tgctggccac cgtggtcgca gcggtcgccc tgctcgcctg catcaccggg
    20461 ctcggcacca ccaccgcggc atgggccgtt cccgctcctt cgaccgcgca ggactcggcc
    20521 gagccggccg cagcccagat gatcgacggc cgggtgacgc tctcgatcga ctcgctgtcc
    20581 cccgaggtcg tcggttccgg gcaggacgtg acggtctcag gaaccatcgc caacggcacc
    20641 gaccggactc tggagcgcat gtccgcgacc gtacaggcgc agaacggcac cgagatcacc
    20701 gtgaccggcc tgaaatcatg gctggccgat gagaccgata cggccatgag caaggtccac
    20761 accggcgacc tcggcgtccg agtggcccct ggcgaggtgc agaccttctc catcgacctc
    20821 gccgcggacg acctgccctt cggagaagcg gatcagtggg gccctcgcgg ccttcagctg
    20881 acgctgtccc aaggagggga cctcattgcc caggaccgca cgatcctggt gtgggacgcg
    20941 ggcgctcagg ccagccggtc gcatacgacg accatcattc cggtgaccgc ctcccccgcg
    21001 gatatgtccc tcctgaccac cggtgcggat ccgccctccc gggacgcgct ggccgacctg
    21061 cgcactcgaa tcgcctctct gctcgcactc gccggcgacg gcgtcgttct cgccgtggac
    21121 ccggccctgc tccacgccct cggagtgacc gaggaaacgc tgaccgctac gacatcctca
    21181 gcgagcgcca gcccctccgc ctccggcggt gccggggacg gagggacaag ctccgcctca
    21241 gctccatcgg cccagccgtc ccaatcggct caggcaccac cctcgccatc gtcatcatcg
    21301 tcagcggatc cgacggccgc tgcctcccct tcaggatcca ctccgagcgc ccagcgcagt
    21361 cccgggcaga ccatcgccaa cgctctcacg cgggccctcg cggccggtga cgtcgtcgcc
    21421 ctgccgtggg cggatgtcga cgtcagcgct ctagcccacc tggatgaaac cgatctgctc
    21481 tccgatgccg cgacccgcac gggaacctcg gaggtcgtgg aggcgggcgc cccgacatcg
    21541 ctgacctggc tcgccggcga cctggacgcc acgacgctgt ccaccctgcc ggactcgacg
    21601 acgaccatcg tcacctcccc gggcgacctg ccggtgacgg cggatctgac gtacacgcct
    21661 tcggaggtga cgagtatcgg ctcgcgtact gtcttgacac ccgatgagga cctgtcggac
    21721 gcgctcggcg gcacactgag gaccggcgaa tcctcgaccg ccctttccga cctggacgcc
    21781 acccagctgc tgcgcggcga gacggcgatc ctcacgcgtc aggcccccgc gataagtcgc
    21841 tccgtcgtgg tgaccctgga ccgcaccgcg gctgcaagca tcgatgccga taggctcgcc
    21901 aggcgcctga aagcgctgca ggactcctcc tggacctcgc cccagggtct gaaggcgctg
    21961 accgccgagg cccgcgccca gcaggacggc ggaacgcggg cgtcgcgcga ggacgtgccc
    22021 gatcaaatcg acggcgacga cgaggtgccg gcctccgatc tcgccgccgc gcgcacgagc
    22081 aaggagtacc tcgattcggt gacctcgatc ctcaccgacc ctcagacggt gatcggctcc
    22141 gcctccgagg tggtggagcg caccgcctcg gccgtgtggc gctcggatcc ggccggtcgc
    22201 acgaccatgg ccggctccgc ccgggagcgg ggcaccgccg tgaccacgag gctcacggcg
    22261 gtgccgtcac ggacgatcaa tctgatcgcc gccgaggcca acctgccggt gcgcatcacc
    22321 tcgtccctgg accaggacgc caccgtcatg gtccgtctgc ggtcgagctc cgctcgactg
    22381 cagacggtcg aagacgtcac actgaccgtt ccggcggacg gtcaggcgac cgccaccgta
    22441 ccggtcaaag cggtgggcag cggagacgtc gacctgacca tcatgctgct ggcggccgac
    22501 ggcaccgccg tcggcgcacc gcagaacgtt catatgcgcg tgcacgccga ctgggagacc
    22561 aggggcaccc gagtcatggg cgccggactc gtcatcctgc tcatcggggg catcgtgcga
    22621 accgtgcgcc gcgggcgacg caccgcgacg cccaccccca gcatcgagga gaagacatga
    22681 gcgccgcgaa caagggttcg tcgatcgccc gctcgagcgc catcatggca gccggaacac
    22741 tggccagccg cattctgggc ctggtgcgca acagcctgct catcgccgcc gtgggagcga
    22801 cggcctcggg cgcgggcgag gccttcaacg acgccaacaa tctgcccacc cagttgtacg
    22861 gcctcatgat cggcggcgtg ctcaacgcca tccttgttcc gcagatcgtg caggcgctgc
    22921 ggcagcgcaa cggcgaggag ctcgtcaacc gtctgctgac ggccgccatc accgccatgg
    22981 tgacagtgac ggccgtcgtc acggtggcgg cgccactggt catcaccttg tacgcctcgg
    23041 gcttgggaaa atggcagcca ctcgccttcg ccttcgccta ctggtgcatg ccccagatct
    23101 tcttctacgg tttgggcgcc ctgtgggggc aggtactcaa cgctcgctcg agcttcgggc
    23161 cctacatgtg gtcaccggtg ctcaacaaca tcatctcgat cgcctcgatc atcgcctacc
    23221 tgcacatcta cggccgctac accactggtc aggatccggc ggtctggaac gcgagtcgca
    23281 tcaccctcat cgcgggcacg acgacggcgg gcatcgcggc ccaggccctc atcctctata
    23341 tccccctggt gcgctcggga ttccgtccgc gcctcgtatg gggggtgcgg ggcatgggtc
    23401 tggggcacat gtcgaaggtg gccctgtggg ccctggcggg cacgggggtc gtcttcctcg
//
