LOCUS       NZ_GL985606            22709 bp    DNA     linear   CON 21-JUL-2024
DEFINITION  Actinomyces sp. oral taxon 448 str. F0400 SCAFFOLD1, whole genome
            shotgun sequence.
ACCESSION   NZ_GL985606
VERSION     NZ_GL985606.1
KEYWORDS    WGS; STANDARD_DRAFT; RefSeq.
SOURCE      Actinomyces sp. oral taxon 448 str. F0400
  ORGANISM  Actinomyces sp. oral taxon 448 str. F0400
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 2812018)
  AUTHORS   Muzny,D., Qin,X., Deng,J., Jiang,H., Liu,Y., Qu,J., Song,X.-Z.,
            Zhang,L., Thornton,R., Coyle,M., Francisco,L., Jackson,L.,
            Javaid,M., Korchina,V., Kovar,C., Mata,R., Mathew,T., Ngo,R.,
            Nguyen,L., Nguyen,N., Okwuonu,G., Ongeri,F., Pham,C., Simmons,D.,
            Wilczek-Boney,K., Hale,W., Jakkamsetti,A., Pham,P., Ruth,R., San
            Lucas,F., Warren,J., Zhang,J., Zhao,Z., Zhou,C., Zhu,D., Lee,S.,
            Bess,C., Blankenburg,K., Forbes,L., Fu,Q., Gubbala,S., Hirani,K.,
            Jayaseelan,J.C., Lara,F., Munidasa,M., Palculict,T., Patil,S.,
            Pu,L.-L., Saada,N., Tang,L., Weissenberger,G., Zhu,Y., Hemphill,L.,
            Shang,Y., Youmans,B., Ayvaz,T., Ross,M., Santibanez,J., Aqrawi,P.,
            Gross,S., Joshi,V., Fowler,G., Nazareth,L., Reid,J., Worley,K.,
            Petrosino,J., Highlander,S. and Gibbs,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2011) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Standard Draft
            Current Finishing Status          :: Standard Draft
            Assembly Method :: Newbler Assembler v. 2.3-04192010
            Genome Coverage                   :: 32.58x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220835.1-RS_2024_07_21
            Annotation Date                   :: 07/21/2024 00:51:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,460
            CDSs (total)                      :: 2,404
            Genes (coding)                    :: 2,339
            CDSs (with protein)               :: 2,339
            Genes (RNA)                       :: 56
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 20 of 65
            Pseudo Genes (incomplete)         :: 50 of 65
            Pseudo Genes (internal stop)      :: 5 of 65
            Pseudo Genes (multiple problems)  :: 9 of 65
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:02:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 140540
            Orig. end                         :: 163249
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GL985606.1.
            Actinomyces sp. oral taxon 448 strain F0400
            Strain source, body site: Oral
            Inquiries should be directed to microbe@hgsc.bcm.tmc.edu
            This is a reference genome for the Human Microbiome Project. This
            project is co-owned with the Human Microbiome Project DACC. This
            sequence is generated as a part of the Human Microbiome Project
            (HMP), funded by the National Institutes of Health (NIH), National
            Human Genome Research Institute (NHGRI) Large-Scale Sequencing
            Research Network and the National Institute of Allergy and
            Infectious Diseases (NIAID) Microbial Genome Sequencing Centers
            Program. The mission of the HMP is to generate resources to enable
            the characterization of the human microbiota, the microbial
            communities living within human bodies, and analyze the role of
            these organisms in human health and disease. See
            http://www.hmpdacc.org/ for more information.
            The sequenced strain was obtained from Dr. Jacques Izard (contact
            information: Forsyth Institute, Department of Molecular Genetics,
            140 The Fenway, Boston, MA, 02135). The genomic DNA was prepared
            from a single bacterial isolate. The sequence generated included at
            least 10 fold coverage of Roche/454 Lifesciences FLX fragment data
            and at least 8 fold clone coverage of Roche/454 Lifesciences
            paired-end data. The Roche/454 Lifesciences sequence was assembled
            using the Roche/454 Lifescience Newbler assembler. This draft
            assembly meets the HMP draft quality standards (more than 90% of
            the genome is included in contigs, more than 90% of a core set of
            bacterial genes are found with > 30% identity and > 30% length;
            more than 90% of the bases in the assembly have more than 5 fold
            sequence coverage, the contig N50 length is greater than 5kb, the
            scaffold N50 length is greater than 20kb, and there is less than 1
            gap per 5kb).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22709
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22709
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22709
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12709](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12709
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(431..445)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    1531..1542
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            1631..2611
                     /locus_tag="HMPREF9062_RS00655"
                     /old_locus_tag="HMPREF9062_0137"
     CDS             1631..2611
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008729505.1"
                     /locus_tag="HMPREF9062_RS00655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0137"
                     /product="metallophosphoesterase"
                     /protein_id="WP_009409667.1"
                     /transl_table=11
                     /translation="MPITHSTARTLARAAGGVTAAGICLLGYTLLEARRPVLRRIDVPV
                     LAPGERPLTVLHLADLHLTDRTEARVAWVRELARVRPDVVVNTGDNLSFASGLEPLARA
                     LEPLLGLPGAFVLGDHDYRTTLFRLPTRYLRTNPVSAYEGLDEAEIALPWEAVRDLQAS
                     GGWTDLTNTRSALITGGRRIDLVGVDDPHAERDAYPAPGHPAQESSGIAVRDRDGHRLR
                     IGLVHSPYRRVLDAMAADGVGLALAGHTHGGQLCLPGVGALVTNCDLDRGRASGLSQWP
                     GRTGTSEATGDMYLHVSAGLGTSPYTPVRLACPPEATLLTLRPAA"
     gene            complement(2661..3227)
                     /locus_tag="HMPREF9062_RS00660"
                     /old_locus_tag="HMPREF9062_0138"
     CDS             complement(2661..3227)
                     /EC_number="3.1.1.106"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003787954.1"
                     /locus_tag="HMPREF9062_RS00660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0138"
                     /product="O-acetyl-ADP-ribose deacetylase"
                     /protein_id="WP_034253427.1"
                     /transl_table=11
                     /translation="MRIEAVTGDITTQQVDAIVNAANRALLGGGGVDGAIHRAAGPELL
                     AACKALRRTELPGGLDVGHAIETPGFDLPARWVIHTVGPNRHAGQNDPRLLRDAFASSL
                     ELAVRLGCRSIALPAVSAGAFGWSMEDVARIAVDQARQLEARAAAPQAVVALELIRFVL
                     ASPRALTTFERELSRTAPSSNPQTR"
     tRNA            3453..3526
                     /anticodon=(pos:144027..144029,aa:Pro,seq:cgg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HMPREF9062_RS00665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HMPREF9062_t0003"
                     /product="tRNA-Pro"
     gene            3453..3526
                     /locus_tag="HMPREF9062_RS00665"
                     /old_locus_tag="HMPREF9062_t0003"
     gene            complement(3624..4256)
                     /locus_tag="HMPREF9062_RS12005"
                     /old_locus_tag="HMPREF9062_0139"
     CDS             complement(3624..4256)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024701.4"
                     /locus_tag="HMPREF9062_RS12005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0139"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_216584396.1"
                     /transl_table=11
                     /translation="MSAQSSSAASGPGRSRRTRNRRGEGWRLREDLLNAADSLLDEVAS
                     PDTISLREVARRAGVSPMAPYRHFASSQELVGEVLTKRFAALAAALTEGVRLDDLFPER
                     ARAQLIVMAERYVEWGRTSSATYHGLFDSSRVPAEQMNMPGAELFDAVATLIGACSTHD
                     DLDAQTAARLFWCGLHGIVSLPERGVLVGWTSDQDMIADLVRLTTSG"
     misc_feature    complement(4246..4261)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.54"
                     /tool="antismash"
     CDS             complement(4253..4459)
                     /gene="allorf_0144793_0144999"
                     /locus_tag="allorf_0144793_0144999"
                     /protein_id="allorf_0144793_0144999"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPTPTIDARASGRDSGRGMKRPARRVRAGGREAVRSRPIEQTVVY
                     CNETMPFPSVAAGRCRVWHTRTM"
     CDS_motif       complement(4370..4459)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPTPTIDARASGRDSGRGMKRPARRVRAGG"
                     /locus_tag="allorf_0144793_0144999_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4253..4369)
                     /prepeptide="core"
                     /locus_tag="allorf_0144793_0144999_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="4328.0"
                     /monoisotopic_mass="4325.2"
                     /core_sequence="REAVRSRPIEQTVVYCNETMPFPSVAAGRCRVWHTRTM"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPTPTIDARASGRDSGRGMKRPARRVRAGG"
                     /leader_location="[4369:4459](-)"
                     /alternative_weights="4346.0"
                     /alternative_weights="4364.0"
                     /alternative_weights="4382.0"
                     /alternative_weights="4400.1"
     gene            complement(4499..5209)
                     /locus_tag="HMPREF9062_RS00675"
                     /old_locus_tag="HMPREF9062_0140"
     CDS             complement(4499..5209)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008731442.1"
                     /locus_tag="HMPREF9062_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0140"
                     /product="response regulator transcription factor"
                     /protein_id="WP_009409670.1"
                     /transl_table=11
                     /translation="MTTSSSSGASGSGGPITVMIVDDQKGARMGMSLMIRRAPDMQVLG
                     LAVDGRDALDQLARLSGAHRPLPHVILMDVRMPVLNGVDATARITQLYPSIRTLVLTTY
                     DQDDYAFGALSAGASGFLLKDSRMAQLHQAIRAVACGDAILTPRITRQLINRHMIRSAT
                     SPQQRAAQNQLGRLSPREREVAELVAQGLTNAEIAQRLIIAPGSVKKNVTRILSKLNLR
                     DRVQLVILMRDVQG"
     gene            complement(5206..6603)
                     /locus_tag="HMPREF9062_RS00680"
                     /old_locus_tag="HMPREF9062_0141"
     CDS             complement(5206..6603)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003789421.1"
                     /locus_tag="HMPREF9062_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0141"
                     /product="sensor histidine kinase"
                     /protein_id="WP_253270623.1"
                     /transl_table=11
                     /translation="MSATPQTMSPRPLLDRVVAAWRTMTRLGGSTPSTIPAPLGSSAEP
                     ARPEPTATEMRAPRTLLDRSVGWWRTSVVTLWGVVAAMALFELLVLNHSLSGNPDISIG
                     SWTLLCILAVLTLLGRRRWPLAAVIATGLASAVTDLWGPRSILALPPLVALYSLFVIAG
                     TLQRVIGLLVITACWILPAVLTGSSPLVEVVAPDVFFLAAAVTAASISRSRREALEHGD
                     AQFAAHTAEQRLTAQRDAARSQARVAAELHDSVGHDLTAILSLSEGLAGITGDAELDEA
                     ITAINALARDGLADTRHAVDALQPAAAEPGRRTPAEQPPAALGPAGALHGWDDLAGVLG
                     TTRRTGLAVALAETGPRPEDPVIADTVFTVVREALTNVMRHAAGATRIVLALDHDDSAT
                     RITVSDDGANTQDVGAQRRPVPPPGNGLTHLADMLRERGGVLSAGPIPGGWSLRAVIPL
                     QPFGKNL"
     gene            complement(6600..7424)
                     /locus_tag="HMPREF9062_RS00685"
                     /old_locus_tag="HMPREF9062_0142"
     CDS             complement(6600..7424)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF9062_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF9062_0142"
                     /product="ABC transporter permease"
                     /protein_id="WP_050795229.1"
                     /transl_table=11
                     /translation="MSVSTVSSLPASPEPFMSSSQRQGSRSGPSVRAAWVWENRKASSR
                     WYWVALVVLCTLGMASGSSQYVSYRDVFDAQGASWLAVWGQATLLPSMMFIPLLVGALI
                     AQIAAGEHAGRNWQRMNANRLQDAMILGKILHMAQVALLSALVLLVEFVITGLLLGFDP
                     AGLGPYAERIVPVAVSILAAELFFAWLGVIMTSFSSVMATVLVVVVAGSAITVMAPRAG
                     ALLPSSFITAACASRDPGSIDSMSSMIFVTLLGILWALVWALALRRAVNRAS"
     misc_feature    complement(6666..6668)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7421..8167)
                     /locus_tag="HMPREF9062_RS00690"
                     /old_locus_tag="HMPREF9062_0143"
     CDS             complement(7421..8167)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="HMPREF9062_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0143"
                     /product="ABC transporter permease"
                     /protein_id="WP_291455118.1"
                     /transl_table=11
                     /translation="MELHKIKRRRFWLMAAGAMGLQFAWVAAATARRASGPPEMRTLEL
                     SLNEVLSLATLMPPIIAAILASRLATVDTEERMGLLLTALGQRESTRFVGKLSLGSIVL
                     VLGQVLLVAYVALMGPGMGLKTTPAYQEALWPALIVVAAASVAAVAVQLTLAICVHKQG
                     VGLGVGALAAFLCSGLPPYHLAPLGWLIPWGVAGAASPIDYAPTLRAGTVLLVSRPWLN
                     SALAVIVAIVWVVLANLVIVYKESHR"
     misc_feature    complement(7544..7546)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8179..9399)
                     /locus_tag="HMPREF9062_RS00695"
                     /old_locus_tag="HMPREF9062_0144"
     CDS             complement(8179..9399)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003789427.1"
                     /locus_tag="HMPREF9062_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0144"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_009409674.1"
                     /transl_table=11
                     /translation="MSTAANSPAPATAPWSAPGRPPAQQSAPATLGPAGQPSSGPGRGA
                     HDLVVATDGLTKTYGDFHAVDHVDLRVPHGGIYGFLGPNGAGKSTTMKLLLGLTRPTSG
                     TMSVMGHPVSVRSPLPAGTIGSLIEGPSYYPRLTGPENLTMVADYLGLPRARVQHTLAT
                     VALTGQDKKLVKDYSLGMKQRLGLAMALLADPPLMLLDEPTNGLDPAGVAEIRQLIMAL
                     ARQEGMTVLVSSHILSEIEQMADIVGIICAGRLRYQGPLSGLQDDGVIDVTVSDPAGAA
                     ALLDEQRIAHQVRGRTVRIPMLPDEVVGDLVTSIVRSNNTVFRVQTVRKTLEQAFLELT
                     DPLGHRSGPAASAASPMPAPGVRPSMTAPDPTSFPAAASPSPVAVGTGYPTAAPTTRIP
                     TGRGVQR"
     misc_feature    9444..9456
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     CDS             complement(9564..9701)
                     /gene="allorf_0150104_0150241"
                     /locus_tag="allorf_0150104_0150241"
                     /protein_id="allorf_0150104_0150241"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPCGTGALVAEVVCHPGVTVVAELLSGAVCVTEQYLCRTFCFTVI
                     "
     CDS_motif       complement(9618..9701)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPCGTGALVAEVVCHPGVTVVAELLSGA"
                     /locus_tag="allorf_0150104_0150241_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9564..9617)
                     /prepeptide="core"
                     /locus_tag="allorf_0150104_0150241_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.30"
                     /molecular_weight="1971.4"
                     /monoisotopic_mass="1970.0"
                     /core_sequence="VCVTEQYLCRTFCFTVI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPCGTGALVAEVVCHPGVTVVAELLSGA"
                     /leader_location="[9617:9701](-)"
     misc_feature    9594..9611
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    complement(9626..9643)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.08"
                     /tool="antismash"
     misc_feature    complement(9712..9727)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            9787..9921
                     /locus_tag="HMPREF9062_RS00700"
                     /old_locus_tag="HMPREF9062_0146"
     CDS             9787..9921
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009402788.1"
                     /locus_tag="HMPREF9062_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0146"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_009409676.1"
                     /sec_met_domain="L_biotic_A (E-value: 8.9e-21, bitscore:
                     70.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADILVEMTDAELDATLGAGNGVFHTISHECYYNSWAFIFTCC"
     CDS_motif       9787..9846
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTADILVEMTDAELDATLGA"
                     /locus_tag="HMPREF9062_RS00700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9847..9921
                     /prepeptide="core"
                     /locus_tag="HMPREF9062_RS00700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.50"
                     /molecular_weight="2728.0"
                     /monoisotopic_mass="2726.2"
                     /core_sequence="GNGVFHTISHECYYNSWAFIFTCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTADILVEMTDAELDATLGA"
                     /leader_location="[9786:9846](+)"
                     /alternative_weights="2746.0"
     gene            10001..12709
                     /locus_tag="HMPREF9062_RS00705"
                     /old_locus_tag="HMPREF9062_0147"
     CDS             10001..12709
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024964.4"
                     /locus_tag="HMPREF9062_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0147"
                     /product="DUF4135 domain-containing protein"
                     /protein_id="WP_009409677.1"
                     /sec_met_domain="DUF4135 (E-value: 2.6e-49, bitscore:
                     165.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-34, bitscore:
                     116.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQSHLVEPTTAVFTQFTDNLRTDLGLNADDWSNERILFYTISPL
                     LLNLHRAKHLGRLHADTSEQRFEEFQTDSGTHDFLEGFKRDNKDIIDRILADNNRDLAF
                     TRSAAAALSRDWSALFEHGYVPTVEPARPIEVTAMGDWHDQEPAARLTAAGVRLFRKGH
                     PSANAAMMTSVWAAIMDGSDDSLLPLTWEESFRSGGYTWSKEVSRLPLTSPEEASAYYA
                     RLGQLLFLAYLLQTSDLHYENIIPHGDCPVLVDSETVGSVRLLPARAPTAAALHIVDRL
                     ADSVLLTGMLPLGAADSGAPDVSAIAANELRREIRVLKDVATDNMRFERRMNITKVTDH
                     LPFTRAQSNGKETRIRYDHYVPSLLTGFREAYNAYLRSTDGVAAAVSQWAEACVTRVLA
                     RNTSEYVAVRQALGSQRFKGRADDVLDHLRRSNTALAGPLIDSECESLRAGLIPSFRCD
                     LTSRNVVDESGRTVCVLDSSPYSTVLDHMAGLSAADRDFQMNIITFALVGAQQMQAHRW
                     SDPSRRAEAIRPARTSPVATAIDTLREQIGDAMVTGPDDSVSWESVTVDDRDNLVISPL
                     SDGIYNGIQGVQHALGQDVTPVSPQILAQDASRSVYLGPSSPLLTQHSPDIDPRESVKD
                     DSVYDVIGGSAGIILSWRHARDLAEIDVIDALAQHLVDSRDTSADVLQWPLERKNRLNN
                     ASFAHGNAGIGTALLVAGVTTGRREYVEVGLAALQTDERLRTADGMWQDLRIEEAPASS
                     SHWCHGATGLAVARITALELDKRTGGDLLPATVRERFTDDLRRVADYLITAIHDTESFS
                     LCHGVAGSLLTLDYLDRTSAVSGYHARIAQAFAEVAAFGLGGDWRCGTDTHQSYALMTG
                     LAGVLHALHVHAGPRPTLEPLLPITPEGMTS"
     gene            12706..14835
                     /locus_tag="HMPREF9062_RS00710"
                     /old_locus_tag="HMPREF9062_0148"
     CDS             12706..14835
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="HMPREF9062_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0148"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_009409678.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.2e-18, bitscore:
                     63.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTILQQSERDCLLACFAMTLSTYGINRQPWQLIRQTTAFESEGI
                     SAAELRALTAGYGLRLRARRGSPSEVWRALTASRETSIVHFTPHHYVVVRAARSRRKMR
                     VHDPAIGRYDLREEDFEERASGAIFSFYPQDTALLAKQAARTPGRYALRRVVNALGQRS
                     HLMMLLAYLLTQVSALGLSWALRDLVDQHRSAAVSALLVTGILLASVLSVVTKVHGTAA
                     GARSFDARYSNRLFSSLLAKPLAYFERNSRGSLMERLSFRFAIRDAIIVSALPQIASTI
                     TSAVIIAYLALLDPWLACGILVCSAAFLAINQVLIGEQNSANVSYILRQQEFGQLVQRD
                     LASIADMITLGVTDSTATAWGESNSRLTDSYIKVVRTTGYSQGLSSIFTFLISAGLALY
                     SAARFQSGAMSLGTLLMIQVAGGLVASGLKDTLTLVVTLNQVRQNTDRHTEIFDSTDAQ
                     HFVDRTVASQDLIEADALTIGFGRNRVIDDVSLRIAPASRTFIVGPSGSGKSTLLKGLV
                     GLLPHTGTIALSPGLRDHLGVAFAETRPGGESVRQALDPRGVGLTDDDGRAALEAVSLR
                     GRVTRLPLGLDSYVSEDGTNLSNGERRRLAIAKALAAGDSLVLLDEPFIGLDEQTVRTV
                     FRQTIGEDRSRAFLIVTHDLELIDDDDAVIFVSGSGTITGSTHASLIRRCPEYADFVGA
                     GSVTARLRGGAGGDS"
     gene            14878..16470
                     /locus_tag="HMPREF9062_RS00715"
                     /old_locus_tag="HMPREF9062_0149"
     CDS             14878..16470
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730647.1"
                     /locus_tag="HMPREF9062_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0149"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_009409679.1"
                     /transl_table=11
                     /translation="MTPWVPAVRRTVPHLPEVVLSALFVALFLVWSWLVLTGCTAAVDR
                     IRPLFLPPRSYAGQIAEAFSLVTHPLVIVIAIAGVTVFSFRRRMRRLALALTVAAAGIP
                     LQTILALTTHRARPHTAFADSISHFGGAYPASHVTAMTLGAWVLVTLTRAHRRPTSSVA
                     QWVGVGVGAVALTAACQWIMGLAHLSDIVGGLLLGAAVANLALSAGGVDSILSAWARLG
                     LPRESTDKRAAVIFNPAKFDDLSLLRRRVEAEVLAAGWSPTLWLETTVDDPGHEPAGRA
                     LDAGVDLVLVAGGDGTVRAVSTELAGTGVPMALLPSGTGNLLARNLGVPMDTDAALRLA
                     LHGRARAIDVVRCETDAPGGESAMTQRFVVMAGLGLDAQIMEDTSDDLKRVIRAGAYAV
                     AAVQNAAPVPFTATVALDDGEPVEQQVVMALLGNVGTITGGVTLFPHASPSDGKVDLML
                     ASPGKVADWARLGAQILTGRDQKGFSTTSASRMRIATDRPVPFELDGDTTGTTRSLTVE
                     IEPEALLVVAPEA"
     gene            complement(16608..17141)
                     /locus_tag="HMPREF9062_RS00720"
                     /old_locus_tag="HMPREF9062_0150"
     CDS             complement(16608..17141)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730639.1"
                     /locus_tag="HMPREF9062_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0150"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_050795231.1"
                     /transl_table=11
                     /translation="MFVEEEADEASTSGGEGGEAILSAACFRLGVLGARVTRSFSERMD
                     GTGLTPKQVGLLAVVDAGTARSQREIAFRMHVAPSLVVSLVDRLVDLGAVRRVRSPTDR
                     RARTIEITAEGRRLLARGIDAAREVDDELRAGLSPVGRSALETFLIESAELIVPTQPVD
                     SARAVGSADPSSGS"
     gene            17195..17542
                     /locus_tag="HMPREF9062_RS00725"
                     /old_locus_tag="HMPREF9062_0151"
     CDS             17195..17542
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017193976.1"
                     /locus_tag="HMPREF9062_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0151"
                     /product="hypothetical protein"
                     /protein_id="WP_034254401.1"
                     /transl_table=11
                     /translation="MPWWLTLLNSVAGAGSAGIAAAAAARPELIAPPGTDPSARFYPTM
                     YAARAVPFGLLVTAVCWLASAYPLTPFILAVAALAQFGDAVIGGLRRLPGMAAGAALAG
                     VCHAVGAIVLF"
     gene            17611..18831
                     /locus_tag="HMPREF9062_RS00730"
                     /old_locus_tag="HMPREF9062_0152"
     CDS             17611..18831
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008731601.1"
                     /locus_tag="HMPREF9062_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0152"
                     /product="carbamoyl-phosphate-synthetase"
                     /protein_id="WP_034253433.1"
                     /transl_table=11
                     /translation="MGRERVLLTEGSSLTAREFVTVLGIRGFEVEVASPSRFPLASFSR
                     WCRAVHRLPPAGTDPVGYLRALDALLATGRYEALLATHEQAWLLAAGQRHLPHATGRLA
                     VASAEAFARVQSKIAFASLCDQLAIPQPTWSEVREEEDLDRIEYPVWVKAAHSTAGRGV
                     RRARTRAEAVSAWRGLAHAGAEGAGVMVQAPAAGAYRQVAGLFEGGRLVAAACSQRIGT
                     GAGGSAAARLSVSDPDAVGVVTRLGAELGWHGGLTCDYFRDDAGRNLFIECNPRTTEPA
                     NAAAAGVDLPALSIALATGRPLPRRPLIARAGARTRSTMALALGAAEAQGTRRAVAGAL
                     KRALTARPPLQGSREVLTPVLRDPPSAVAALAGVGTVLVRPGAVTALAGGAVDAYAITP
                     RTIARLA"
     CDS             19035..19232
                     /gene="allorf_0159575_0159772"
                     /locus_tag="allorf_0159575_0159772"
                     /protein_id="allorf_0159575_0159772"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPFRDDSLCHGNLGNWTALRPVATRTEAHEPLVPCLAESVIATTN
                     RSKAARRIRPGSPPTASRSP"
     CDS_motif       19035..19067
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPFRDDSLCHG"
                     /locus_tag="allorf_0159575_0159772_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       19068..19232
                     /prepeptide="core"
                     /locus_tag="allorf_0159575_0159772_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="5578.3"
                     /monoisotopic_mass="5575.1"
                     /core_sequence="NLGNWTALRPVATRTEAHEPLVPCLAESVIATTNRSKAARRIR
                     PGSPPTASRSP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPFRDDSLCHG"
                     /leader_location="[19034:19067](+)"
                     /alternative_weights="5596.3"
                     /alternative_weights="5614.3"
                     /alternative_weights="5632.4"
                     /alternative_weights="5650.4"
                     /alternative_weights="5668.4"
                     /alternative_weights="5686.4"
                     /alternative_weights="5704.4"
                     /alternative_weights="5722.5"
                     /alternative_weights="5740.5"
                     /alternative_weights="5758.5"
     CDS             complement(19238..19300)
                     /gene="allorf_0159778_0159840"
                     /locus_tag="allorf_0159778_0159840"
                     /protein_id="allorf_0159778_0159840"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MDVRVRRSQSIGSASGCSVL"
     CDS_motif       complement(19262..19300)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDVRVRRSQSIGS"
                     /locus_tag="allorf_0159778_0159840_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19238..19261)
                     /prepeptide="core"
                     /locus_tag="allorf_0159778_0159840_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.50"
                     /molecular_weight="599.7"
                     /monoisotopic_mass="599.3"
                     /core_sequence="ASGCSVL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDVRVRRSQSIGS"
                     /leader_location="[19261:19300](-)"
                     /alternative_weights="617.7"
     gene            complement(19339..19725)
                     /locus_tag="HMPREF9062_RS00735"
                     /old_locus_tag="HMPREF9062_0153"
     CDS             complement(19339..19725)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003785149.1"
                     /locus_tag="HMPREF9062_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0153"
                     /product="VOC family protein"
                     /protein_id="WP_009409683.1"
                     /transl_table=11
                     /translation="MPDFCPNSIILYVADVELSTAFYSRILGRGPQETFEGFAVFALSR
                     AVTLCLQEAAAIEPAAEPHVGGSELSLSDVGRDDVDRIYARWRELGVPMMLEPTELDFG
                     YTFVAVDPDGHRLRVCATDTSGLS"
     misc_feature    19933..19944
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            20110..20370
                     /locus_tag="HMPREF9062_RS13335"
                     /old_locus_tag="HMPREF9062_0155"
     CDS             20110..20370
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF9062_RS13335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF9062_0155"
                     /product="hypothetical protein"
                     /protein_id="WP_009409685.1"
                     /transl_table=11
                     /translation="MLAQSVIVPRSRWAPPTLLRVGTCLGAMGFALLAVDGGLVLIVIS
                     VTMIGMGIGIATPGYTAGPTLLMSRTAPTAARAGRRRPGRG"
     gene            complement(20432..20845)
                     /locus_tag="HMPREF9062_RS00745"
                     /old_locus_tag="HMPREF9062_0156"
     CDS             complement(20432..20845)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003786215.1"
                     /locus_tag="HMPREF9062_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0156"
                     /product="type II toxin-antitoxin system VapC family toxin"
                     /protein_id="WP_009409686.1"
                     /transl_table=11
                     /translation="MTIYYLDTSAALKLLIEEDESEPLAQWLNQTVSHSPDSAGDIALC
                     SSFLLSTELHCAARRRRELDEEAVATLLSGVELVDVSREHLLNAAGDSAGLRSADAIHL
                     TVALDIRSDALLTYDREMRIAARRRGLGVVAPA"
     gene            complement(20842..21102)
                     /locus_tag="HMPREF9062_RS00750"
                     /old_locus_tag="HMPREF9062_0157"
     CDS             complement(20842..21102)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075617.1"
                     /locus_tag="HMPREF9062_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0157"
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_216584397.1"
                     /transl_table=11
                     /translation="MSTTITHRELRNSSASILRRVQAGETFEVTNNGEPVALLSPMGGE
                     RLALLRRRGAVTPRARVDFARLKRATGIASRDALDDLRGER"
     gene            21266..21400
                     /locus_tag="HMPREF9062_RS13740"
                     /old_locus_tag="HMPREF9062_0158"
     CDS             21266..21400
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF9062_RS13740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF9062_0158"
                     /product="hypothetical protein"
                     /protein_id="WP_009409688.1"
                     /transl_table=11
                     /translation="MAGPEGRGGSGKDWRARNRERRSALADGAVDAYAITPRSIARLS"
     gene            21459..22124
                     /locus_tag="HMPREF9062_RS00755"
                     /old_locus_tag="HMPREF9062_0159"
     CDS             21459..22124
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008729545.1"
                     /locus_tag="HMPREF9062_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF9062_0159"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_009409689.1"
                     /transl_table=11
                     /translation="MPVPIRMTKIHHACLTIDDGSTRILLDPGKFGPRPGLDGVDAVLI
                     THRHVDHLDPDLVAEALRRGIPVWAPGDALGDIGVPDGIEDGGLHEAVPGTTLRIGSLP
                     VQVAGERHAELHPALPGPENRAYLIDQRLFVTGDEHPVPPGRLTTLVTPADAPWLRATD
                     LIRYVRDVRPELVVGVHDGLLNADGLSVARHVIDALRNEGATGATMLADGESIDIPRG"
ORIGIN
        1 ccgctcggcc gcccgcaaga tccgtgagat caagtacgca ctgaccctgg agcagaggta
       61 ctccaagcag cagatcctcg aggggtacct caatatcgct gccttcggcc cgtcgaccta
      121 cggggtcgag gcctccgcgc ggcactactt ctcgcactcc gccaaggacc tgtcgatcac
      181 cgagtcggcg ctcctggcgg gcctgaccaa cgcaccgggc gcgtacgatc cgatcgccta
      241 cccggacaag gcgaaggacc gtatgaactg ggtcctggac aagatgcaca aggaggagtt
      301 catcaccgat gaggaatggc aggccggtta caacactcag atctccgaca ttctgaacgt
      361 gtcggacacc gtcggaggct gcggcacggc cggatcggcg gcctacttct gcgagtacgt
      421 ggtctccgag atcgagaact ccgatctcta cggagccacg gaggccgagc gcaagcagct
      481 gctcctgcga ggaggactga cgatcaccac cacgctcgat cagagcaagc agcaggcggc
      541 ggacgacgcc gtgcagcact acgtgccgac acgagacccc tccaacgtca aagccgcact
      601 ggcctccgtc gaaccgggca cgggccgcat catggccatg agtcagaaca cggactacgg
      661 cgtgacgacc gacagcgatt cctcagtgac gcagatctcc ttcagtgcgg acgcctccca
      721 cggcggtctg gagaccggcg gcggcagctc cggattccag ccgggctcga ccttcaaggc
      781 cttcgtcctg gcggagtggt accaggaggg ccgctccggc tacacatcca tgaacacctc
      841 gccgcggacc ttcggacgct cgacgtggaa catctcctgc gatccctcca aggccgacac
      901 atgggacgtc aggaacgcca atgactccga gagcggagcg cacaacgtga ttcagagtac
      961 tgctcagtcc atcaacgtcg gcttcgccca gatgacctcc gaaatggaca tctgcaacat
     1021 cacgaacctg gccgccaagc tcggggtcac caataactcc ggcgatcccc tgactccaac
     1081 gccctcgatc gcactgggct cgcaggaggt cacgccgctg cagatggcca acgcctacgc
     1141 gtcattcgca gcccacggcg tgtactgccg tccgatcgcc atcgactcca tcgaggacgc
     1201 cgacggcagt ccgatggacg tgccctccgc caactgctgg caggcgatgg acgccaccgc
     1261 cgcggatcag acagcgctga ccctcaccca cgtattcgat aaggacggca ccggaaagga
     1321 cattcctctc agcggccgga cggcggccgg caagaccggt acgaccgagg acatggacaa
     1381 cgcctggttc acaggcttca caccgcagct ggcggcgtcc gtgtggctgg gccactcgga
     1441 gggctactcc cggatggacc accagaccat cggcggtcac tactacacga ccatgtacgg
     1501 ttcggacgcc ccggcgccgc tgtggcagca gtacatgaac gaggcgctgg cgggacaacc
     1561 cgatccgggc ttcagtcagc cgagcctcgg ggctcatgcc tccggaaccc cgggcgggaa
     1621 ctgacacgca atgcccatca cgcacagcac ggcgcgcacg ctcgcccgtg ccgcgggagg
     1681 tgtgaccgcc gcggggatct gcctgctcgg ctatacgctc ctggaggcgc gccgccccgt
     1741 cctgcgtcgt atcgatgtcc ccgtcctcgc ccccggcgag cggcccctga cagtcctgca
     1801 cctggcggat ctgcacctga ccgaccgcac tgaggctcga gtggcctggg tgcgggagtt
     1861 ggctcgagta cgcccggacg tcgtcgtcaa caccggggac aacctgtcct tcgccagcgg
     1921 cctggaacca ctcgcgcgcg cgctcgaacc cctcctcggc ctgcccggag ccttcgtcct
     1981 gggagaccac gactatcgca cgacgctttt cagactcccc acgcgctatc tgcgtacgaa
     2041 cccggtgtcg gcctacgagg gactcgacga ggccgagatt gcgctgccgt gggaggcggt
     2101 gcgcgatctg caggcctcgg gcgggtggac cgatctgacc aacacccgca gcgcactcat
     2161 cacgggcggc agacgcatcg acctggtagg cgtggatgat ccgcacgccg aacgcgacgc
     2221 ctatcctgcg ccggggcacc cggcgcagga aagctcggga atcgcggtgc gcgaccgcga
     2281 cggccatcgg ttgcggatcg ggctggtcca ctccccctat cggcgcgtgc tcgacgccat
     2341 ggcggccgac ggcgtcgggc tggcactggc aggccacacg cacgggggtc agctgtgcct
     2401 gcccggtgtc ggagcgctgg tgaccaactg cgacctcgat cgggggcggg cctcaggcct
     2461 gtcgcaatgg ccggggcgca ccggcacgtc ggaagcgact ggtgacatgt acctgcacgt
     2521 ctcagcgggg ttgggcacga gcccgtacac gcccgtgcgt ctggcctgtc ctcccgaagc
     2581 gaccctactc acgctgcggc cggcggcctg aacgcgattc cacttcccat ccgcatctcg
     2641 acgccggatc agcggcgacc ctatcgggtc tgcggattgc tcgacggcgc cgtgcgcgag
     2701 agttcgcgct cgaaggtcgt cagggcccgt ggtgaggcga ggacgaaacg gatgagttcc
     2761 agggcgacca cggcctgcgg ggcggcggcg cgggcctcca gctgccgtgc ctggtcgacg
     2821 gcgatccggg cgacatcctc catcgaccat ccgaaggcgc cggcgctcac ggccggcagg
     2881 gcgatggaac ggcagcccag ccgaacggcg agctccagac tgctcgcgaa ggcgtcgcgc
     2941 aggagtcggg ggtcgttctg cccggcgtga cggttcgggc cgacggtgtg gatgacccac
     3001 cgggcgggca agtcgaagcc tggagtctcg atggcgtgcc cgacgtccag gccgccgggc
     3061 agctcggtgc ggcgcagcgc cttgcaggcg gcgagcagct ccgggccggc ggcacggtgg
     3121 atggcgccat cgactcctcc tccgcccaga agcgcgcggt tggcggcgtt gacgatggcg
     3181 tcgacctgct gcgtggtgat gtcaccggtg acggcttcga ttctcatcct gatctccctc
     3241 ccggtctccc cggacccgca cgcaccgtcg gcctggagtc ggcgggcgac gactccgggc
     3301 cgggatcgat agcggcgggg cgagagcacg tgcgacgtca gtgaacccgc ttcccgacgc
     3361 aggatgcaag accgagcggc gcgtgaccga cgcctcctca gccgaatttc cttccattgt
     3421 gacgatccga ctatgctgtt ccctgctgca cgcggggtgt ggcgcagctt ggtagcgcgc
     3481 ttcgttcggg acgaagaggc cgtgggttca aatcccgcca ccccgacgac gagcacgtcg
     3541 acgagctcgc tcgtatgacg tgcgaggagg gcggtgctgc aggccaccga gctgaatggc
     3601 taccgaactt cgccgcgacg ccctcagccg gaggtcgtca gacgcacgag atccgcgatc
     3661 atgtcctggt ccgatgtcca accgacaagg acgccgcgtt cgggcaacga cacgatcccg
     3721 tgtagcccgc accagaacag gcgcgccgcc gtctgcgcgt ccaggtcgtc atgcgtcgag
     3781 caggcaccga tcagcgtggc aacggcgtcg aacagctcag cgccgggcat attcatctgc
     3841 tcggcgggca ccctggaact gtcgaacaga ccgtgatagg tggcggagct ggttctcccc
     3901 cattccacgt agcgctcggc catgacgatc aactgggcac gggcccgttc ggggaacagg
     3961 tcatcgagcc tcaccccctc agtcaaggcc gccgcgagcg ccgcgaagcg cttggtgagc
     4021 acctcgccga ccagctcctg gctgctggcg aagtgacggt agggcgccat cggcgagaca
     4081 ccggcgcgtc gtgccacctc gcgcagggag atcgtgtccg gggacgcgac ctcgtccagc
     4141 aggctgtcgg ccgcgttgag caagtcctcg cgcaggcgcc atccttcgcc tcgacgattg
     4201 cgtgtacgcc ggctccggcc ggggccggac gcggctgatg aggactgtgc gctcacatcg
     4261 tgcgagtatg ccagacccga catcggcctg cggcgactga cgggaacggc atggtctcgt
     4321 tacagtaaac gactgtctgc tcaatcgggc gggaccttac tgcctcgcgt cctccggcac
     4381 ggacgcggcg ggcggggcgc ttcatgcccc gccccgagtc ccggcctgaa gcccgggcgt
     4441 cgatcgtcgg cgtcggcacg tgagccggtc catccgggcc cgtagacgcc agcgggtttc
     4501 atccctggac gtcgcgcatg aggatgacga gctgcacccg gtcgcgcagg ttcagcttgg
     4561 acaggatgcg ggtgacgttc ttcttcaccg agccgggggc gatgatcagg cgctgcgcga
     4621 tctcggcgtt ggtcagtccc tgggcgacga gttcggccac ctcgcgctca cgcgggctca
     4681 gcctccccag ctggttctgg gcggcgcgct gctggggcga ggtcgccgag cggatcatgt
     4741 gccggttgat cagctggcgg gtgatgcgcg gggtgagaat ggcgtcgccg caggcaacgg
     4801 ctcggatcgc ctggtggagc tgcgccattc gactgtcctt gagcaggaag cccgaggctc
     4861 cggcggacag cgcgccgaag gcgtaatcgt cctggtcgta ggtggtcagc accagcgttc
     4921 tgatggacgg gtagagctgg gtgatgcgcg cggtggcgtc gaccccgttg aggacgggca
     4981 tgcgaacgtc catgagtatg acgtggggca gcggccggtg ggcgccgctc aggcgggcga
     5041 gctggtcgag ggcgtcccgg ccgtcgacgg cgaggccgag gacctgcatg tcgggggccc
     5101 gtctgatcat gagggacatg cccatgcggg cgcccttctg gtcatcgacg atcatgacgg
     5161 tgatcggccc gccggacccg cttgcgccgc tggaggatga ggtcgtcata ggttcttccc
     5221 aaagggctga agggggatga cggcgcgcag gctccatccg ccggggatgg ggccggcgct
     5281 caggacgcca ccgcgctcgc ggagcatatc ggccaggtgg gtcagcccgt tgccgggcgg
     5341 gggcacgggt cgtcgctggg ctccgacatc ctgggtattg gcgccgtcgt cggacaccgt
     5401 gatccgggtg gcggagtcgt cgtggtccag agcgaggacg atgcgggtgg cgcctgcggc
     5461 gtggcgcatg acgttggtta gggcctcgcg cacgacggtg aagacggtgt ccgcgatgac
     5521 gggatcctcg gggcgcggtc cggtctcggc cagggcgacg gcgaggccgg tgcggcgcgt
     5581 ggtgcccagg acgccggcga ggtcgtccca tccgtggagg gcgccggccg gtccgagggc
     5641 ggcggggggc tgctcagcag gcgttctcct gcccggttcg gcggcggcgg gctggagggc
     5701 gtcgacggcg tgacgcgtgt cagcgagtcc gtcgcgggcg agggcgttga tggcggtgat
     5761 ggcctcgtcg agctcggcgt cccccgtgat gcccgccagg ccctcggata gggagaggat
     5821 ggcggtcagg tcgtgcccta cggagtcgtg gagctcggcg gccacgcgcg cctggctgcg
     5881 ggcggcgtcg cgctgtgcgg tgagccgctg ctcggcggta tgggcggcga actgggcgtc
     5941 gccgtgctcg agggcctctc tgcgggaccg ggagatcgat gccgcagtga cggcggcggc
     6001 gaggaagaag acatcggggg caaccacctc gaccagggga gaggaaccgg tcagaacggc
     6061 ggggaggatc cagcaggcgg tgatgacgag caggccgatc acgcgctgaa gggtcccggc
     6121 gatgacgaac agggagtaga gggccaccag cggaggcaga gccaggatcg acctcggtcc
     6181 ccacaggtcg gtgaccgctg aggccaggcc ggtggcgatg acggccgcga gcggccagcg
     6241 gcgtcggccg agcagggtca gcacggcgag gatgcacagg agcgtccatg agccgatgct
     6301 gatgtcgggg ttcccggaca gagagtggtt caggacgagc agctcgaaca gggccatggc
     6361 ggccacgacg ccccacagcg tcacgacgct ggtgcgccac cagccgacac tacggtccag
     6421 gagggtccgc ggggccctca tttccgtcgc ggtcggctcg ggccgagcgg gctccgcgga
     6481 tgatccgagg ggtgcgggaa ttgtcgacgg agtcgagccc ccgagccggg tcatggtgcg
     6541 ccatgcggcc acgacccggt ccaggagggg gcgcggggac attgtctgcg gggtcgcgct
     6601 catgaggccc ggttgacggc acgccgcagc gccagtgccc atacgagcgc ccacaggatg
     6661 ccgagtaaag tgacgaagat catagaactc atggagtcga tactaccagg atcacgagaa
     6721 gcacaggctg cggttatgaa cgacgacggg agaagagcac cggcccgagg agccatcacc
     6781 gtgatagcgg acccagccac aaccaccacc agcacggtag ccatgaccga ggagaatgat
     6841 gtcatgataa cgccgagcca ggcgaagaac agctcagcgg caaggatcga cacggcaaca
     6901 ggaacaatgc gctctgcgta cggcccgagc cctgccgggt cgaatccgag cagcagcccc
     6961 gttatgacga actccaccag gagtaccaac gcactgagca gtgcgacctg ggccatatgg
     7021 aggattttac cgaggatcat agcgtcctgc agacggttcg cgttcatacg ctgccagttt
     7081 cgtcccgcat gctcgccggc ggcgatctgc gcgatgagcg cccccacgag tagagggatg
     7141 aacatcatgg acggcagaag cgttgcctgt ccccacacgg ccagccagct cgccccctga
     7201 gcatcgaata cgtcccgata actgacatac tggctcgatc cggacgccat cccaagagtg
     7261 cacaagacca ccagcgccac ccagtaccaa cgactggagg ccttacggtt ctcccacacc
     7321 caggccgccc gcaccgacgg accagatcga gatccctgac gctgcgaaga actcatgaag
     7381 ggctccggcg aggccgggag cgaagagact gttgagacgc tcatcggtga ctctccttgt
     7441 aaacgataac gaggttggcc agtacgaccc agacaatggc gacgatgacg gcgagtgcag
     7501 aattgagcca tgggcgagac accagcaaga ccgtgccggc gcgtaatgtg ggagcgtaat
     7561 caatcgggct ggcggcacca gcgacccccc acggaatcag ccagcccagc ggtgccagat
     7621 gatagggcgg cagaccggag cagaggaagg ccgccagagc gccgaccccc agtccgacgc
     7681 cctgtttgtg aacgcagatc gccaatgtca gctgaaccgc caccgccgcc accgaggcgg
     7741 ccgccacgac gatcagggcg ggccacagcg cctcctgata ggccggtgtt gttttcagcc
     7801 ccatccctgg acccatcagg gcgacatacg ccacaagcag aacctggccg agcacaagga
     7861 caatggaccc cagagagagc ttcccgacaa aacgggtgct ctcacgctgc cccagagcgg
     7921 tgagcagcaa ccccatccgc tcttcggtgt ccaccgtcgc cagacgggag gccagtattg
     7981 ctgcaataat cggcggcatc aacgtagcca gagagaggac ctcattaaga gacaactcca
     8041 gcgtacgcat ctcaggaggt ccgctagccc gcctggctgt agcggcagcc acccatgcga
     8101 actggagacc catagcccct gcagccataa gccagaagcg gcgccgcttg atcttgtgta
     8161 gctccatgcc gatggtgctc accgctgcac cccccgcccg gtcggaatac gggtggtggg
     8221 agcggccgtc ggataaccgg tgcccacggc caccggcgag gggcttgcgg ccgccgggaa
     8281 cgaggtgggg tcgggcgcgg tcatcgacgg gcggacgccg ggggcaggca tcggcgaggc
     8341 ggcgctcgcg gccgggccgg atcggtggcc gagcgggtcg gtgagttcga ggaaggcctg
     8401 ctccagggtc ttacggaccg tctgcacacg gaacacggta ttgttcgagc gcacgatgct
     8461 ggtcaccagg tcgccgacca cctcgtcggg aagcatgggg atgcgcaccg tccggccgcg
     8521 gacctggtgg gcgatgcgct gctcgtcgag cagggcggcc gcacccgccg gatcggagac
     8581 ggtgacgtcg atgacgccgt cgtcctggag cccggacagc gggccctgat agcgcaaccg
     8641 cccggcgcag atgatgccga cgatatccgc catctgctcg atctcgctga ggatgtggga
     8701 ggagacgagg acggtcatgc cctcctggcg ggccagagcc atgatgagct ggcggatctc
     8761 ggcgacgccg gcggggtcca gtccgttggt cggttcgtcc agaagcatga gcggagggtc
     8821 ggccaggagg gccatggcca gccccagacg ctgcttcata cccagggagt agtccttgac
     8881 gagcttcttg tcctggccgg tcagtgcgac ggtggccagg gtgtgctgga cgcgcgcccg
     8941 cggcaggccg agatagtcgg cgaccatggt gagattctcc gggccggtga gcctcgggta
     9001 gtaggagggc ccctcgatga gggagccgat ggtaccggcc ggcaagggcg agcggacgct
     9061 caccgggtgg cccatgacgc tcatggtccc cgaggtgggg cgggtcaacc ccaggaggag
     9121 cttcatggtg gtggacttcc cggcgccgtt ggggccgagg aacccgtaga tgccgccgtg
     9181 ggggacccgc aggtccacgt ggtcgacggc gtggaagtcg ccgtaggtct tcgtcaggcc
     9241 gtcggtggcg acgaccaggt cgtgcgcgcc gcgtccgggg ccggaggacg gctgtcccgc
     9301 cgggccgagc gtcgcgggag ccgactgctg cgcgggcggc cggcctggag ccgaccaggg
     9361 cgcggtcgcg ggtgcggggg agttcgctgc tgtgctcatg gagccatgag acctcgaggc
     9421 cgtgcccgcc cgcaccgctg gagctgaagc tgtcacccat ggggtactgc cgcgggccgg
     9481 cgacccggca ggtcggagta ttccccggaa tcatgaggtt tcactctatc gacatcaccg
     9541 ccgtcagcgg caccacgatc aaatcagata acagtgaaac aaaaagtgcg acaaagatat
     9601 tgttctgtta cgcaaaccgc cccggataac aattccgcaa ccactgtcac cccagggtga
     9661 caaacgactt cagccactag cgctcccgtc ccacaaggca aagactcgtc ccgtgaccgc
     9721 gatcaccgtc gggtggcttt cggatctcac cctcacacct cactcagaac cacgaaagga
     9781 catattatga ctgctgacat tctcgttgag atgaccgacg ccgaactcga cgccaccctc
     9841 ggcgcaggga acggggtgtt ccacaccatc tcccacgagt gctactacaa ctcctgggca
     9901 ttcatcttca cctgctgctg accattgacc gtccaatagg ccggtagaca cgtaaaccag
     9961 cacgagaccc gaaagtcacc cgacccccgg aagaatcccc atgatccagt cacacctcgt
    10021 tgagcccaca accgccgtct tcacacagtt caccgacaat ctacggaccg atctcggcct
    10081 caacgccgac gactggtcca acgagcgtat ccttttctac accatttctc ccctgctcct
    10141 caacctgcac agggccaagc acctcggccg tcttcacgcg gacacctccg agcaacggtt
    10201 cgaggagttc cagaccgact cgggaacgca tgatttcctc gagggcttca aacgagacaa
    10261 taaagacatt atcgaccgga tcctggccga caacaaccgc gacctggcct tcacccgctc
    10321 cgccgccgcg gcactctccc gggactggtc ggccctgttc gagcacggct acgtccccac
    10381 cgtcgaaccg gcccggccga tcgaggtcac cgccatgggc gactggcacg accaggagcc
    10441 cgccgcacgt ctgaccgccg ccggcgtccg cctgttccgc aagggccatc ccagtgcgaa
    10501 tgccgccatg atgacgtcgg tctgggcggc gatcatggac ggctctgacg actcgctcct
    10561 gcccctgacg tgggaggagt cattcagatc ggggggctac acctggtcca aggaggtcag
    10621 tcgactgccg ctcaccagcc ccgaggaggc cagcgcctac tacgcgcgcc tcggtcaact
    10681 gctgtttctg gcctatttgc tgcagaccag cgacctccac tatgagaaca ttattccgca
    10741 cggggactgc cccgtcctcg tcgattccga gaccgtgggc tccgtgcggc tcctccccgc
    10801 cagagcgccc accgcggccg cgctgcatat cgtcgaccgg ctggcggaca gcgtgctctt
    10861 gaccggcatg ctgccgctgg gcgcggcgga cagcggcgcc cccgacgtct cggccatcgc
    10921 cgcgaacgag ctgcgccgcg agatccgggt tctcaaagac gtggcgaccg acaatatgcg
    10981 cttcgagcgc cgcatgaaca tcacgaaggt cacggaccac cttcccttca cgcgcgcaca
    11041 gtccaacggg aaggagaccc gtatccggta cgatcactat gttccgtcac tcctcaccgg
    11101 cttccgcgag gcctacaacg cctacctgag gagcaccgac ggtgtggcgg cggccgtctc
    11161 tcagtgggcc gaagcgtgcg tgacgcgcgt cctggccagg aacaccagtg agtacgtcgc
    11221 cgtccgtcag gccctcggca gccagcgatt caagggccgt gccgacgatg tactcgacca
    11281 cctgcgccgt tcgaacaccg cgctcgccgg gcccctcatc gactcggagt gcgagagtct
    11341 gcgcgcgggc ctcatcccct ccttccgctg cgacctcacg tcgaggaacg tcgtcgacga
    11401 gagcggccgc acggtctgcg tcctcgactc aagcccctac agcacggtgc tcgaccacat
    11461 ggcgggactg tctgccgcgg accgggactt ccagatgaac atcatcacct tcgccctggt
    11521 cggtgcccag cagatgcagg cccatcgctg gagcgacccc tcccgccggg ccgaagcgat
    11581 ccggcccgcc cgcacctcac cggtcgcgac ggccatcgac accctgcgcg agcagatcgg
    11641 cgatgctatg gtcaccggcc cggacgactc cgtgagctgg gagagcgtaa cggtcgacga
    11701 cagggacaat ctcgtcatca gtcccctctc cgacgggatc tacaacggca tccagggcgt
    11761 ccagcacgcc ctcggacaag atgtcacccc ggtcagcccc cagatcctgg cccaggacgc
    11821 gtcacgctcg gtctacctcg gcccgtcgag ccccctcctc acccagcact cgcccgacat
    11881 cgacccgcgg gagtccgtca aagacgactc cgtgtacgac gtcatagggg gcagcgccgg
    11941 aatcatcctc tcatggcgcc acgcccggga cctcgcggag atcgacgtga tagacgcgct
    12001 ggcgcagcac ctggtcgact cccgggacac ctcagccgac gtcctccagt ggccgctgga
    12061 gcgaaagaac cggctcaata acgccagctt cgcccacgga aacgctggaa tcggcaccgc
    12121 cctgctcgtg gccggggtga caaccggacg ccgggagtac gtcgaggtgg ggctggccgc
    12181 cctgcagacc gacgagcgcc tgcgcaccgc cgacggcatg tggcaggacc tgcgcataga
    12241 ggaggcgccg gcatcgagct cccactggtg ccacggggcg accggactgg cggtcgccag
    12301 gatcaccgcc ctcgagctcg acaagcgcac cggaggcgat ctgctccccg caaccgtccg
    12361 cgagcgcttc acggacgacc tgcgccgcgt ggccgactac ctgatcaccg caatccacga
    12421 caccgagagc ttctcgctgt gccacggcgt cgccggcagc ctgttgacac tggactacct
    12481 cgacaggaca tcagccgtca gcggctacca cgcccggatc gcacaggcct tcgccgaggt
    12541 cgcggcgttc ggcctgggcg gggactggcg ctgcgggacg gatacccacc agtcctacgc
    12601 gctgatgacc ggcctggcgg gcgtcctgca cgccctgcac gtccacgcgg gtccccgccc
    12661 cacgctggag ccgctgctcc ccatcacgcc cgagggcatg acctcatgag gacaatactt
    12721 cagcagtccg agcgcgactg cctgctggcc tgcttcgcca tgacgctcag cacgtacggc
    12781 atcaacaggc agccgtggca gctgatcagg cagaccaccg ccttcgagtc ggagggcatc
    12841 tccgcggcgg agctgcgcgc cctcaccgcg ggctacggcc tgcggctgcg ggccagacgc
    12901 gggagcccgt cggaggtctg gagagctctc acggcgtccc gggagacttc gatcgtgcac
    12961 ttcacgcccc accactatgt cgtggtcaga gcggcgcgga gccggcggaa gatgcgggtt
    13021 catgacccgg ccatcggccg ctacgacctc cgtgaggagg acttcgagga gcgtgcgagc
    13081 ggcgctatct tctcctttta cccccaggat accgcgctgc tggcgaagca ggcagcgcgg
    13141 actccgggga ggtatgccct gcgccgcgtc gtcaacgccc tgggccagcg cagccacctc
    13201 atgatgctcc tggcctacct cctgacgcag gtcagcgcac tcggcctgtc ctgggcgctg
    13261 cgcgacctgg tcgaccagca ccggagcgcg gcagtatccg ccctcttggt gaccggcatc
    13321 ctgctggcgt ccgtcctgtc cgtcgtcaca aaggtgcacg ggactgccgc cggggcgcgc
    13381 tccttcgatg cgaggtactc caaccgactc ttctcgagcc tgctcgccaa gccgctggcc
    13441 tacttcgagc gcaacagccg cggaagcctc atggaaaggc tcagcttccg cttcgccatc
    13501 cgtgacgcga tcatcgtctc ggccctgccg cagatcgcat ccacgatcac gtccgcggtc
    13561 atcatcgcct acctcgctct cctcgacccc tggctcgcct gcggcatcct cgtctgctcg
    13621 gcggcgttcc tggccatcaa ccaggtcctc ataggcgagc agaactcggc gaacgtctca
    13681 tacatcctca ggcagcagga gttcggccag ctcgttcagc gcgacctggc gagcatcgcc
    13741 gacatgatca ccctgggggt gacggactcg accgcgacgg cgtgggggga gtccaacagc
    13801 aggctgaccg actcctacat caaggtcgtg cggacgaccg gctactcgca ggggctgtcg
    13861 agcatcttca cgttcctgat cagcgccggc ctggcgctct actccgccgc acggttccag
    13921 tcgggcgcca tgtccctggg caccctcctt atgatccagg tcgcgggcgg cttggtcgcc
    13981 agcggtctga aggacacgct caccctcgtg gtgactctga accaggtccg tcagaatacc
    14041 gaccgacaca cggagatatt cgacagcacc gatgctcagc acttcgtgga ccgcactgtc
    14101 gcgtcccagg acctgatcga ggcggatgcg ctgaccatcg ggttcgggcg gaaccgggtc
    14161 atcgacgacg tcagcctgag gatcgccccg gcgtccagga cattcatcgt cgggccgtcg
    14221 ggaagcggga agtccacgct cctcaagggg ctcgtcggcc tcctcccgca cacgggtacc
    14281 atcgccctgt cccccggcct cagggaccat ctgggggtcg ccttcgcgga gacgcgaccg
    14341 ggaggggagt ccgtccggca ggccctcgac ccgcgcgggg tcggcctgac ggacgacgat
    14401 ggccgggcgg ctcttgaggc ggtgtccctg aggggacggg tgacccggct cccgctgggg
    14461 ctcgactcct acgtctccga ggacgggacc aacttgtcga acggggagag gaggaggctc
    14521 gccatcgcca aggcgctcgc ggccggtgac agcctcgtcc tgctggacga gccgttcatc
    14581 ggcctcgacg agcagaccgt ccgtacggtc ttccgccaga cgatcggcga ggaccggtct
    14641 cgggccttcc tcatcgtcac gcacgacctc gagctgatcg atgatgacga cgccgtcata
    14701 ttcgtctcgg gatcggggac gatcacgggt tcgacgcacg cctccctgat ccgccgatgc
    14761 ccggagtacg ccgacttcgt cggcgcgggg tctgtcacgg cacgccttcg gggcggggcg
    14821 ggaggagact cgtagcatgg gcgcggcgat tctcgcactg ctggtaagga ggttgcgatg
    14881 acgccctggg tcccagcggt gcgacggacg gtcccgcacc tgcctgaggt cgtcctgtcc
    14941 gcgctgttcg tcgcactgtt cctcgtctgg agctggctgg tcctgaccgg gtgcaccgcc
    15001 gctgtcgacc gcatccgccc actcttcctc ccgccgcgct cctacgcggg tcagatcgcc
    15061 gaggccttct ccctggtcac ccaccccctc gtcattgtca tcgccatcgc gggtgtcacc
    15121 gtcttctcct tcaggcgacg catgcggcgc ctggccctgg ccctgaccgt cgccgccgca
    15181 ggcatccccc tgcagacgat cctcgccctg accacccacc gcgcccggcc gcacaccgct
    15241 ttcgccgact cgatctctca cttcgggggc gcctacccgg ccagccatgt caccgccatg
    15301 accctgggcg cctgggtcct cgtcactctc acccgtgctc accggcgccc cacctcctcg
    15361 gtcgcccaat gggtcggggt cggcgtcggc gccgtcgcac tgaccgccgc gtgccagtgg
    15421 atcatgggcc tggcccacct gtccgacatc gtgggcgggc tgctgctggg ggccgcggtg
    15481 gccaacctgg cactgagcgc cggcggtgtc gactcgatcc tgtccgcctg ggcgcggctg
    15541 ggcctaccgc gcgagagcac cgataagcga gccgccgtca ttttcaaccc ggccaaattc
    15601 gacgacctgt cgctgctgcg gcgccgcgtc gaggccgagg tgctcgccgc ggggtggagc
    15661 ccgaccctct ggctggagac cacagtcgac gatcccggtc acgagccggc cgggcgggcg
    15721 ctcgacgccg gcgtcgacct cgtcctggtg gccggcgggg acggaacggt acgggccgtc
    15781 tccaccgagc tggccggcac cggcgtgccc atggcgctgc tgccctcggg caccggcaac
    15841 ctgttggccc gcaatctcgg cgtgcctatg gacaccgacg ccgccctgcg cctggcgctg
    15901 cacgggcgcg cccgggcgat cgacgtcgtg cgctgcgaga ccgacgcccc aggcggtgaa
    15961 agcgcgatga cccagcgctt cgtcgtcatg gcgggcctgg ggctggacgc ccagatcatg
    16021 gaggacacga gcgacgacct caaaagggtc atccgcgccg gcgcctacgc ggtggccgcg
    16081 gtgcagaacg cggcgccggt ccctttcact gcgacagtcg ccctcgacga cggcgagccc
    16141 gtcgagcagc aggtggtgat ggcgctgctg ggcaacgtcg gcacgatcac cggcggggtg
    16201 acgctgttcc cgcacgcctc gccgtcggac ggcaaggtgg acctcatgct cgccagcccc
    16261 ggaaaggtgg ccgactgggc gcggctgggg gcgcagatcc tcaccggccg ggaccagaag
    16321 ggcttctcga cgacctcggc gtcccggatg cgcatcgcga ctgataggcc ggtccccttc
    16381 gagctcgacg gcgacaccac cggcaccacc cgctcgctca cggtcgagat cgagcccgaa
    16441 gcgctcctgg ttgtcgctcc cgaggcgtga gcgaggatcg gagggcccag cggtggcgtt
    16501 cccggtccgg cgcacctgat cgagcgggcg agacggcgcc gcgtcgtcgc agcaggtcga
    16561 gtcggtccat gtccgttcgg catgtctccc tcccatgcgg ctcgcgctca ggaacctgag
    16621 gagggatcgg ctgacccgac ggctcgggca gaatcaacgg gctgagtcgg cacgatcagc
    16681 tcagccgact caatcaggaa ggtctccagg gccgagcgcc cgaccgggga caggccggcg
    16741 cgcagctcgt cgtcgacctc ccgtgcggca tcgatgccgc gggcgagaag ccggcgtccc
    16801 tccgcggtga tctcgatcgt gcgcgctctg cggtcggtgg gtgagcggac ccggcgaaca
    16861 gctccgaggt cgacgagccg gtccacgagc gagacgacca ggctcggggc cacatgcatc
    16921 cggaatgcga tctcccgctg agaccgggcg gtccccgcgt cgacaacggc gagcagcccc
    16981 acctgcttgg gggtcagccc ggtgccgtcc atccgctcgg agaaggacct cgtgacccgc
    17041 gcgcccagga ctcccagccg gaagcacgcc gccgacagga tcgcctcgcc gccttctccc
    17101 ccactcgtac tcgcttcatc cgcttcctcc tccacgaaca taatgttaca gtacagaatc
    17161 attcattatt gaacgatctg aggttgtgat cctgatgccc tggtggctca ccctgctgaa
    17221 ctcggtcgca ggtgccggct ccgccggcat cgcggccgca gccgcggcac ggccggagct
    17281 catcgcgccg cccgggaccg accccagcgc ccgcttctac ccgaccatgt acgcggcacg
    17341 agccgtgccc ttcgggttgc tggtcaccgc ggtctgctgg ctcgcgtccg cgtacccgct
    17401 gactccgttc atcctggccg tcgccgcgct cgctcaattc ggagacgccg tcatcggcgg
    17461 cctacggcgt cttccgggca tggcggcggg ggcggcgctc gccggcgtct gccacgccgt
    17521 cggcgctatc gtcctcttct gatcggccgt gccgggtcgg ccactatccg ccgcctaaat
    17581 gagccgagga gattccatta agctctgtcc gtgggccgag agcgcgtgct gctgacagag
    17641 gggtcgagtc tgacggcccg cgagttcgtt accgtcctgg gcatccgcgg attcgaggtg
    17701 gaggtcgcct ccccgagccg attcccgctg gcgtcgttca gcagatggtg tcgagccgtg
    17761 caccgcctgc cacctgccgg gaccgaccct gtcggctacc tgcgcgctct cgacgccctg
    17821 ctggccaccg ggcgctacga ggcactgctg gccacccatg agcaggcgtg gctactcgcg
    17881 gcaggacaac ggcacctgcc gcacgccacc gggcgcctgg ccgtcgccag cgcagaggcc
    17941 ttcgcacggg tgcagtcgaa gatcgccttc gcttccctgt gcgatcagct cgccatcccc
    18001 cagccgacct ggagcgaggt gcgcgaggag gaggacctgg accgtatcga atatccggtg
    18061 tgggtcaagg ccgcccactc gaccgctgga cgcggtgtgc gtcgagcccg aacgcgtgca
    18121 gaggcggtct cggcgtggcg gggtctcgct cacgccgggg ccgagggggc gggcgtcatg
    18181 gtgcaggctc cggccgcggg ggcctaccgg caggttgccg ggctcttcga aggcggccgg
    18241 ctggtcgcgg ccgcctgctc ccagcgcatc gggaccggtg cgggcggctc cgcggcggcc
    18301 cgcctatcgg tatcagaccc ggatgcggtc ggagtcgtca cgcgtctggg ggcggagctg
    18361 ggctggcacg gcggtctcac gtgcgactac ttccgcgacg acgctggacg taacctgttc
    18421 atcgagtgca atccccgcac caccgagccc gccaacgccg ctgcggcggg tgtcgacctg
    18481 ccggcgctct ccatcgccct ggccaccggt cgtccactgc cccggcgtcc gctcatcgcc
    18541 agggccggag cgcgcacacg ctcgaccatg gcgctcgctc tgggcgcggc cgaggcccag
    18601 gggacccgcc gagcggtcgc cggcgcgctc aagcgggccc tgaccgctcg tccgcccctt
    18661 caaggtagtc gcgaggtcct gacccccgtc ctgcgggacc cgcccagtgc ggtcgctgcc
    18721 ctggccggcg tcggcaccgt cctcgtgcgg cccggcgccg tcacggctct ggcgggcggc
    18781 gccgtcgacg cctacgccat cacgccgcgc accatcgccc ggctggcctg agcaccggca
    18841 cccgctccaa gccgagcccc gcatcccgtc atcgatcacg atccgaaata gcaggacacc
    18901 cacgtagacc gcgtcgaccg cgtccgtcac gaggccgcca tgacagcgcc cgcgaaggcc
    18961 cacggcaacg tgcgacggac caccagtacc gctagtaccg ccgccaccgg cgcccaagag
    19021 caccacacac aagcatgcct ttccgggacg attcgctctg ccacggcaac cttggaaact
    19081 ggacggccct ccgcccggtc gcaacccgga ccgaggccca cgaacccctg gtcccctgcc
    19141 tggctgaatc agtcatcgcc actacgaacc ggtcgaaggc cgctcggaga atcagacccg
    19201 gatccccgcc gactgcctct cgaagtccgt gacacgctca cagcactgag cagccggacg
    19261 ctgaacctat ggactgagat cgtcggacac gcacatccac gaggcgatgc gcgaagtgaa
    19321 gaacgccgag caggacgatc agctcaggcc cgaggtgtca gtcgcgcaca cgcgcaggcg
    19381 atggccatca ggatcgacgg caacgaaggt gtagccgaaa tcgagctcgg tcggctccag
    19441 catcatgggc acgcccagct cccgccaccg ggcatagatg cggtcgacat catcgcgacc
    19501 gacatcgctc agcgacagct cgctgccacc cacgtgaggc tcggccgcag gctcaatcgc
    19561 cgccgcctcc tgcagacaga gggtcacggc ccgcgacaag gcgaagacgg cgaacccctc
    19621 aaaggtctcc tgcggcccgc gtccgaggat cctggagtag aaggcggtgc tgagttcgac
    19681 gtcggcgacg tagaggatga tgctgttcgg gcagaagtcc ggcatagcca gtccttatct
    19741 cacgacggcc ggggcggcgc cccgaagaac aaagccgacg ctaacagcgg tcggcgacac
    19801 cgtgcggggc acgcagacgc tcggcccggg cgacgctcac gcctcgacca cgcgggagct
    19861 gctcgcgggc ctgccggtgg tcatggtcgc cctgcgccga gagactcgga ccgagccggc
    19921 cgccgagccc gcgtacatga accccttcgg cccggcctgg cacttcctcg tcgcggggtt
    19981 cggcatgctc accgcactgg ggatcatcag agtcgtcacc ggcttcctcg tacacgacct
    20041 cctcgctctg gacgcggaca tgacggcctc gtcaccggcg gggcgctgct ggcggccggc
    20101 atcgggctgg tgctcgccca gagcgtcatc gtgccgcgct cgaggtgggc accccccacc
    20161 ctgctgcgcg tcggcacctg cctgggggcc atgggcttcg ccctgctcgc ggttgacggc
    20221 ggactcgtgc tcatcgtcat ctcggtgacg atgatcggca tgggcatcgg catcgccacg
    20281 cccggctaca cggcgggtcc cacgctgctc atgagccgta cggcgccgac ggcggccagg
    20341 gcggggagac ggcggccagg gcggggatga ggctgggcgg gtcccggtga atcggagcga
    20401 ggacctcgcg gctcccccgc agggtccgcg atcaggccgg cgcgaccacc cccagcccac
    20461 ggcgacgcgc ggcgatccgc atctcacggt cgtacgtgag aagggcatcg gagcggatgt
    20521 ccagggcgac cgtcaaatga atggcgtctg cggagcgcag ccccgccgag tctccggcgg
    20581 cattcagcag atgctccctg gagacgtcca cgagctcgac ccccgacagc agcgtcgcga
    20641 ccgcctcctc gtccagttcg cgacggcgcc tggcggcgca gtggagttcc gtggagagaa
    20701 gaaaggacga gcacagggcg atatcgcccg cactgtcagg actgtgcgac acggtttgat
    20761 tgagccattg tgccaacggc tccgactcat cctcctcgat gaggagcttg agcgccgcgg
    20821 acgtatccag gtagtagatc gtcaccgttc gccgcgcaga tcatccagcg catcccgaga
    20881 tgcgatgccg gttgcgcgct tcaaccgggc gaagtccaca cgggccctcg gagtgacggc
    20941 cccgcgccgc ctgagaagag caagacgctc gccgcccatg ggagagagca aagccaccgg
    21001 ctccccgttg ttggtgactt cgaaggtctc ccctgcttga acacgacgaa ggatcgacgc
    21061 actgctattg cgcaactcgc gatgcgtaat cgtggtcgac acggccatca cctcgtcgca
    21121 accgtagcac acgagtcctc ggagtgacgc tcccgcgccg caccacttcg aagcgatcga
    21181 ctccagcctc ggcctgctcg aactgcaggg tcaccgcggg cagaggcgtc cgtcgggccc
    21241 gaacgcgcac cgaggcggcc tcggcgtggc gggccctgag ggccgcggag gctccgggaa
    21301 ggactggaga gcgcggaacc gcgagcgccg ttcagctctg gcggacggcg ccgtcgacgc
    21361 ctacgcgatc acgccgcgct ccatcgcccg gctgtcctga gcgcggcctc cgctcccggc
    21421 cgggccccgc tccggcggcg gcgcggtagc ctgtcgtcat gccggtcccg atccgaatga
    21481 cgaagatcca ccacgcctgc ctgacgatcg acgacgggag cacgaggatc ctgctcgatc
    21541 ccgggaagtt cgggccccgc ccgggcctgg acggagtcga cgccgtgctc atcacccacc
    21601 ggcacgtcga ccacctcgac ccggacctcg tcgcggaggc gctgcgtcgc ggaatccccg
    21661 tctgggcgcc gggggacgcg ctcggggaca tcggcgttcc cgacgggatc gaggacggcg
    21721 gcctgcacga ggcggttccg ggcacgacgc tgcgcatcgg ctccctgccc gtccaggtgg
    21781 ccggcgagcg tcacgccgag ctgcacccgg ctctcccggg tccggagaat cgcgcctacc
    21841 tgatcgacca gcggctgttc gtcaccggcg atgagcaccc ggtcccgccg ggccgtctca
    21901 ccaccctggt cacgcccgct gacgcgccct ggctgcgcgc caccgacctg atccgctacg
    21961 tgcgcgacgt gcgccccgag ctcgtcgtcg gtgtccacga cggcctgctc aacgcggacg
    22021 ggctctcggt cgcccgccac gtgatcgacg cgctgcggaa cgagggcgcg accggggcca
    22081 ccatgctcgc cgacggcgag tcgatcgaca tcccccgggg ctgagaacca tcgcgcgtcg
    22141 gggccgttca ggggcgggag gcaacggcgc agcccgcggt agaggggcct cgggccgggg
    22201 gtcatgtcca ccggatcgca gtccggctcc tcgagccgat cgctcttctc ccaccaggtg
    22261 gggaagtcgt cgtcggtcac gacgtgcctc gccgatgagg atctcctggg gtggagccgc
    22321 gcgatgcagg ctgatccgcc gccgacgtgg gcgccccggg cgccatcgcg tcccggtggc
    22381 cctagactgg cgccgcccag tcctcgaccc gcaggagccg cacccatgga cctctccccc
    22441 gcagcgtccc tgcgctcgcg catcaccgtg gctctgggcc gcacggcccg tctggtctcc
    22501 cgtctgcgcg gcggcggctc gggcgggacc gcgctgccgg gcctggtcgt cgagaagacc
    22561 gatcccggct ttctggcccg caccctgggc cagctgccca tgggcgtgat cgtcgtctcg
    22621 ggcaccaacg gcaagacgac gacgaccaag atggtcgttc agctcctgcg cgagcagggt
    22681 ctaacggtgc tgaccaaccg ctccgggtc
//
