LOCUS       NZ_CP023202            11911 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6911418
            Orig. end                         :: 6923329
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11911
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="26"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11911
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11911
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6911](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6911)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(20..35)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.44"
                     /tool="antismash"
     misc_feature    386..401
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    386..402
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 25.44"
                     /tool="antismash"
     misc_feature    complement(387..402)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 26.64"
                     /tool="antismash"
     gene            466..642
                     /locus_tag="SXIN_RS31665"
     CDS             466..642
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SXIN_RS31665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_185831325.1"
                     /transl_table=11
                     /translation="MCQRVTCRTCGKFTYSGCGGHVDQVLAGVPASKRCDCDSAAGKAK
                     AGGSGWKSLFGRG"
     gene            complement(833..1729)
                     /locus_tag="SXIN_RS29625"
     CDS             complement(833..1729)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016850.4"
                     /locus_tag="SXIN_RS29625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CmcI family methyltransferase"
                     /protein_id="WP_157916359.1"
                     /transl_table=11
                     /translation="MQDAPQAAGADGEFLPDADVASAIAGSRRVVRRKVAAQNGVPTFF
                     DNRMLLLAEIAHSALDGAPDSRRSGQFRAAVTELTDFLRRAEAPRFADPTERLRRSLRE
                     VHAAMAADQRTIHRSQGVVSTLTWAGLPLVKSVYDAAIIPMLISELRPASIIELGSGSG
                     ASAVWMADVAASAGLEPAVLSVDRNPVAARDARVTFRRGDLTEIGTVLGLAELSALEHP
                     WLVVEDAHVNVRGVLAHFDTVARPGDYLVIEDSIVKRAELLAFLESDGRRYALDTRYTD
                     AFGENVTSAVDSILVRR"
     gene            complement(1698..3137)
                     /locus_tag="SXIN_RS29630"
     CDS             complement(1698..3137)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SXIN_RS29630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="insulinase family protein"
                     /protein_id="WP_095757813.1"
                     /transl_table=11
                     /translation="MRASRARTPRTRLVPVHLPGRLTASASLLLRHGAGADPPGREGTG
                     STWAVLLRRDGGAGERGARECFETGLEELGTTLTLSLGWQAVRLTLDSTPDCLADALAL
                     LARVLGAFRPTPQEVRALARHRGRALAAARRAPGGSAGPLLDAALFPGSRYGRGMAGDA
                     GSAARVDADAVHAFHRGVLSAPRDLVVAADLARVDLRALVRACPSPAPETAAERLHRGS
                     SEPGRPSPADNFAARVRPLTLRRRTGGGGCVVMLGVRATARDDAPLILEIARRLLVATA
                     SSRLSRALRDASALAYSVHGELWQDGGVCSLRLRFEVAQALVAPAAVTALGELFGLAAG
                     EVDADDLRSTVEAYRRDSAATTGSPAAVAAAGAVSPAVPAEHPPEGLTPDRFRARAAEL
                     LAPERVAVVVDGALHGPEEIRRAVTAAARRDPPGRADALLAYARRVAASGTESSGDGIG
                     DDGDVGQEEEIDAGRTTSSRS"
     gene            complement(3134..4435)
                     /locus_tag="SXIN_RS29635"
     CDS             complement(3134..4435)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017044.4"
                     /locus_tag="SXIN_RS29635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pitrilysin family protein"
                     /protein_id="WP_019707903.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 7.2e-18, bitscore:
                     63.5, seeds: 24, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M16_C (E-value: 1e-11, bitscore:
                     43.7, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERYDAPHGPLSTTRLANGLTVVAQRDPALRGLHVHLRYDVGSRH
                     EAPGHHGLAHFLEHLMFLGTRRHPDFLETLRRAGARDVNASTNQDRSAFTMTVPSELLP
                     LALAMEADRMTNLAREFDERALAGHLALVRREERERCRGPFGDAARLLFEHAYPPGHPY
                     RHPSMGDTDALGRLSPEEVARFHRLHYRPERATLVVVGDLDPDTVAGTAATTLGAAPGG
                     GDVPPPPDRPSGPLRTSPAVARTTCPGGTPPRVYALLHTPPYGAREHPAYAVLAAVLGL
                     GRGSRLFRSAVRGARIARPAGELLASWELERGSSLLYGAVAATPGTTGARLLDGVRTAL
                     TSVSGGLAPRELQRAVRLVRWQRLAGLDDPARRAEAFAVHTRVTGGAHHAYTAAEAVAD
                     VTEQAVVHAAGRSTAAATFLVCDEAGTVAAETAR"
     gene            complement(4442..5008)
                     /locus_tag="SXIN_RS29640"
     CDS             complement(4442..5008)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.3"
                     /locus_tag="SXIN_RS29640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5825 family protein"
                     /protein_id="WP_095757814.1"
                     /transl_table=11
                     /translation="MSEPARTTTRSSLLVPCSPEEAPGRETLAAWARSGMRGLVINRPV
                     RLSTTDPAATVRFLHLLTEAAGTGLRVYWEGGTGDVPAELLHHLDPPRGDAGPAWPVPP
                     APLLTLRRGPGFVVVDDLRDARAPRRHTVPDRPYGHLLRRYAAPAAPDPGDRRALARLA
                     KERLVLALDPGHCLALPVRFAYARV"
     gene            complement(5001..6911)
                     /locus_tag="SXIN_RS29645"
     CDS             complement(5001..6911)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="SXIN_RS29645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_095757815.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.3e-169, bitscore:
                     563.9, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.3e-11, bitscore: 43.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTEFLGLPEAPERGPVRTLRVALVCMPWAALDMPSMAISTLAP
                     AARALEEVDAVDTVYANIRWADHVHERTGGAIGSADYGRIVDGYYVATGEWIFSPALYG
                     FEEPVGSAFHTAATGSGADLRAAVEMYRLSSGFVDALAGELAAGGYDLVGMTSTFDQNM
                     PSLALARALKERAPGVVTVMGGANCDDVQGEALHRNFSFLDYVVRGEGESVFPALLRLL
                     ARTEPGAAPAAARLAAVPGLCWRDAGGRARANEQPSAGLPIDAVPEADLSGYFATFRAA
                     RAVADVEPKIQLEGGRGCWWGEKHHCTFCGLNGSLMAFRAKSSDRVLAEIANAVRDHQV
                     LDVVFADNIMDMGYLRDLLPKLAEQPWDLRLFFEIKSNLGMGQLKVLADAGVTQVQPGI
                     ESLSTHVLRLMRKGVTGWQNVRLLRDSRTVAVFPGWNFLYGFPGETEADYEQIIEQLPG
                     LWHLTPPEGVYRAVLTRFSPFYNDPALGLENLGPSGLLQKVYRLPAEEVADIGYVFESR
                     PAGISEEVADRLRAAVDTWRAHHRGRRLVALPEGDTLRIVDERSPTPVQEVLRTPLAVA
                     AFRATLKGRSAAGVTREVTAQGIPGTEDRVTGLLEEWRERRWLFHEDGRYVALPTGLGH
                     E"
     gene            complement(6924..7610)
                     /locus_tag="SXIN_RS29650"
     CDS             complement(6924..7610)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327692.1"
                     /locus_tag="SXIN_RS29650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_238153893.1"
                     /transl_table=11
                     /translation="MHSLLDVVLAEVGDDAAGPGGCGLLPLDGRLRGPAGTDPVLASPL
                     PAAGVPLARTAAEVAAAGLGMRTLALVVKEETGLRTLALVDGWLLLRGHGAGTDLRGAD
                     LRGADLTGARLTGADLSGADLSGSRLESADLARAGLRSADLSGATLRRASLFGADLTEA
                     DLRRTDLRHSDLRESTCRRTAFRGADFWSAYVWDVSFDEAFTEGAGIERADYRGTHLPK
                     PVNARV"
     gene            complement(7603..8289)
                     /locus_tag="SXIN_RS29655"
     CDS             complement(7603..8289)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039455.3"
                     /locus_tag="SXIN_RS29655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6445 family protein"
                     /protein_id="WP_095757816.1"
                     /transl_table=11
                     /translation="MTAPRVERALGGDVLVVDGFYQDPDRVRELALAAEYRGFGEAANF
                     PGRESVKAYASEGHARRLAEIVGAPVFHDPRQLVFGKFRIATRSDAGQTRVHLDFVDWT
                     AVVYLSPAEHARGGLGFYRHLPTGLDRVPADGELARFGCRSREEFDERYVLRDTASEDR
                     WETLHEVELAYNRCVVFRGGRLFHGITELFGDAPGEGRLTQNFFFMEGEPVRAPRTGDE
                     RSRTRA"
     gene            complement(8286..8951)
                     /locus_tag="SXIN_RS29660"
     CDS             complement(8286..8951)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039455.3"
                     /locus_tag="SXIN_RS29660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6445 family protein"
                     /protein_id="WP_050930718.1"
                     /transl_table=11
                     /translation="MRSRLIVVDDFYADPDSVRAAALRSDFKSASRYNYPGWQSNKALS
                     TDALQRAIERIVGSAVHVDGDRLTWGGFRVITEETGRATKVHADTAVDWAGMVYLTPGA
                     PAAAGTGFFRHRETGFSRPPSDRVARSLGFADADAFEEGVARRDMADLGKWELTDWVAP
                     VYNRLVLFRGCELYHAPLGGLGDRPANARITHNFFFNEVRSVPGAVRRMPAPAEAAAR"
     gene            complement(8951..9556)
                     /locus_tag="SXIN_RS29665"
     CDS             complement(8951..9556)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039455.3"
                     /locus_tag="SXIN_RS29665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6445 family protein"
                     /protein_id="WP_019707900.1"
                     /transl_table=11
                     /translation="MVDDFYADPDRVRALALERGDWSPQKTDEGRTYDAETYNSFAGRG
                     VAEAFGEILGIRVRYDPAVMGFGVFAFTGESANVPLTTHYDDTDWAGIVYLVPPGRCDG
                     GLSFFRHRDSGLLGPPDDAKAVELGYDDREHWMKDVYFPDKVRPEAWEEMSRVSMVYNR
                     LVLLRGGTRFHRASSGFGTGPADGRLTQRFFFDEERAS"
     gene            complement(9546..10844)
                     /locus_tag="SXIN_RS29670"
     CDS             complement(9546..10844)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="SXIN_RS29670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_019707899.1"
                     /transl_table=11
                     /translation="MSAPAPPRKSSLPSRFWLFWSCLTAGSLADGMTLIALTWAAATVT
                     DNAFSIALVAMAERLPWLLFALPMGALVDRLPRVGLMAVTGAARAAAMLVLGVLLLATD
                     VPVAVLALFALFFGATEVAYGVAADTAVPLLVPGQGLARANGHVRASQILSNDFVGRPL
                     GGLLLKSGLAVPFLGNALLNGASAGALLLMRRRVNDPPPPAPAGSGSVRAELGAGLHLV
                     WRDPLLRVLAASAVVLNSFYATMLAGQVLFVRETLGLDALGYALLLSCAALGGVAGSQY
                     ARRLLDRWGVERSLTAALWAMALCFLGVGLIPAVPVVVGLYALASAGVALWSVTTLTVR
                     QLAVPDAKLGRVNATFRTVTFGMSAVGMLLGGLLVEAAAGPLGLRDALRVPYLASGAAY
                     LLLAGFLRLRLGDGRIVTGKRGESDRQDTAGGR"
ORIGIN
        1 aagcgcctgg ccgcactgac cgaacgcgaa ctcgacaccg cccacgccat cgcggacggt
       61 cagggcaacc cggagatcgc cgagcgcctg cacatcagcg tcgccaccgt gaaagcgcac
      121 accagcagcc tgttcgccaa gctggcggtc gagaacaggg tgcagatcgc cctggtggtg
      181 cgcgacgagg cggaatgacc tccgcaccgt ccgggagccg ggctcctcgg acaagaactc
      241 ccctggcatg ggcctcacgc catgggcgtc cgccggcacc ccgggatctt ccgccgaacc
      301 ccgtcaccgg gcccggccgt ggtgccggac gctcaggatc acagccttgg cgttcaccgc
      361 cgtaacgatg ttccccgagg ccgggatacc cccttggggt tttgtctttg ataccccagg
      421 gggtatagtc ggccgcaggg aagagaccaa cgaagggaaa gtgccatgtg ccagcgtgtt
      481 acctgccgta cctgcggaaa gttcacctac tcgggatgcg gtggacatgt cgaccaggtg
      541 ctggcgggcg tcccggcctc caagcgctgc gactgcgact cggcggcggg caaggccaag
      601 gccggcggct ccggctggaa gtcgctcttc ggccggggct gacgcgcggc gccccaccgc
      661 gcacgcccgt gcgcggtggg gcgctcgcat gccgtgggcc ggcacacggg gtccggccgc
      721 agccggcgcc gcggcggaag accgggaccg gcgccgggcc gctccggcct ccgggccggt
      781 gacgtggctc acggggaacc cccgacggtc gtccccgccc gcgggaggcg tcctaccggc
      841 gcacgaggat cgagtccacg gcgctggtga cattctcccc gaaggcgtcc gtgtagcgcg
      901 tgtccagggc gtaccgccgc ccgtccgact cgaggaaggc cagcagttcg gcccgcttga
      961 cgatgctgtc ctcgatgacg aggtagtcgc ccggccgcgc aacggtgtcg aagtgcgcga
     1021 ggacgccccg gacgttgacg tgggcgtcct cgacgaccag ccacgggtgt tccagggccg
     1081 acagctcggc caggcccagc accgtcccga tctcggtgag gtcgccccgg cggaaggtga
     1141 cgcgcgcgtc ccgcgcggcc accgggttcc ggtcgacgga gaggacggcc ggctccagcc
     1201 ccgccgaagc ggcgacgtcc gccatccaga cggcgctcgc ccccgagccg gagccgagtt
     1261 cgatgatgct cgccggccgc agctcggaga tcagcatggg gatgatcgcg gcatcgtaga
     1321 cggacttgac gagcggcaga cccgcccagg tcagggtcga cacgacgccc tgactccgat
     1381 ggatggtgcg ctggtcggcg gccatcgccg cgtgcacctc ccgcagcgat ctgcggagtc
     1441 tctccgtggg atcggcgaac cggggcgcct ccgcccggcg gagaaagtcg gtcaactccg
     1501 tcaccgcggc gcggaattgc cccgaccggc gggaatccgg cgcgccgtcg agggcggagt
     1561 gcgcgatctc ggcgagcagc agcatcctgt tgtcgaagaa cgtgggaacg ccgttctgcg
     1621 ccgccacctt cctccgtacc accctgcggg accccgcgat ggccgacgcc acatcggcgt
     1681 ccgggaggaa ctccccgtca gctccggctg cttgtggtgc gtcctgcatc gatttcctct
     1741 tcctgtccga catccccgtc gtcaccgatg ccgtcgcccg aggactccgt gccggaggcg
     1801 gcgacgcggc gggcgtaggc gaggagcgcg tccgcgcggc ccggcgggtc ccgccgggcg
     1861 gcggccgtga cggctcgccg tatctcctcc ggcccgtgga gagcgccgtc caccaccacc
     1921 gccacccgct ccggcgcgag caactccgct gcccgggcgc gaaaccggtc cggggtgagg
     1981 ccctccggcg ggtgctccgc cggtacggcc ggcgacacgg cgccggctgc tgccacggcc
     2041 gcggggctgc cggtggtggc ggcgctgtcc cgccggtacg cctcgaccgt gctgcgcagg
     2101 tcgtccgcgt ccacctcccc ggccgcgagg ccgaacagct cgccgagcgc ggtcactgcg
     2161 gccggggcca ccagggcctg ggccacctcg aagcggagcc ggagcgagca gaccccgccg
     2221 tcctgccaca gctcgccgtg cacggagtag gccagggcgg aagcgtcccg cagggcccgg
     2281 gagagccggg acgaggcggt tgccacgagg aggcggcggg cgatctccag gatcaggggg
     2341 gcgtcgtccc gggccgtggc ccggaccccg agcatcacca cgcacccccc gcccccggtg
     2401 cgtcgccgca gggtcagggg ccgcacccgg gcagcgaagt tgtccgccgg gctcggccgg
     2461 ccgggctccg aagacccccg gtgcagcctc tccgccgccg tctccggcgc cggagacggg
     2521 caggcccgga cgagggcgcg caggtccacc cgcgcgaggt cggcggcgac cacgaggtcg
     2581 cggggcgcgc tcagcacgcc ccggtgaaag gcgtgcacgg cgtcggcgtc gacgcgcgcg
     2641 gcggagccgg cgtcaccggc catgccgcgt ccgtaccggc tgcccgggaa cagtgccgcg
     2701 tcgagcagcg gtcccgcgga tccgccgggt gcccggcggg ccgcggcgag ggcccggccg
     2761 cggtgccgcg cgagtgcccg cacctcctga ggcgtggggc ggaacgcgcc gaggacccgg
     2821 gccagcaggg cgagggcgtc cgccaggcag tccggagtcg agtcgagcgt gagccggacc
     2881 gcctgccacc ccaggctgag agtgagggtc gtgcccagct cctccagccc ggtctcgaag
     2941 cactcccgcg ctccccgctc cccggctccg ccgtcgcggc gcaggagcac cgcccaggtg
     3001 gacccggtgc cctcccggcc cggggggtcc gctcccgcac cgtgccgcag cagcagggac
     3061 gcggaggccg tcagcctgcc gggcaggtgg acggggacca gccgggtccg gggcgtccgt
     3121 gcgcgggacg ccctcaccgc gcggtctccg cggccacggt gcccgcctcg tcgcagacga
     3181 ggaaggtcgc ggcggccgtg ctgcgcccgg cggcgtgcac gacggcctgc tcggtgacgt
     3241 cggcgaccgc ctcggccgcg gtgtacgcgt ggtgcgcccc gccggtgacg cgggtgtgga
     3301 cggcgaacgc ctccgcccgc cgggcggggt cgtccagccc ggcgagccgc tgccaccgga
     3361 cgagccggac ggcccgctgg agttcccggg gcgcgaggcc gccggagacc gaggtgagag
     3421 cggtccgcac gccgtccagc aggcgtgccc cggtggtgcc cggtgtggcg gccaccgcgc
     3481 cgtagagcag cgagctgccc cgctccagtt cccacgaggc cagcagctcc ccggccgggc
     3541 gggcgatgcg ggcgccgcgt acggccgagc ggaacagccg gctgcccctg cccaggccga
     3601 gaaccgccgc cagcacggcg tacgcggggt gttcccgggc gccgtacggc ggagtgtgca
     3661 gcagggcgta cacccggggc ggggtgcctc cggggcaggt ggtccgggcg acggcgggtg
     3721 aggtgcggag cgggccggag ggccggtccg ggggtggcgg gacgtcgccg cccccggggg
     3781 cggcgccgag ggtggtggcg gccgtgccgg ccaccgtgtc cgggtccagg tcgccgacca
     3841 cgaccagggt ggcccgctcg ggccggtagt gcaggcggtg gaagcgggcg acctcctccg
     3901 gggagaggcg gcccagcgcg tccgtgtcgc ccatcgacgg gtggcggtac gggtggccgg
     3961 gagggtacgc gtgctcgaag agcagccgcg ccgcgtcgcc gaagggcccg cggcagcgct
     4021 cccgttcctc ccgccggacc agcgccagat ggccggcgag ggcccgctcg tcgaactccc
     4081 gcgccaggtt ggtcatccgg tcggcctcca tggccagggc cagcggcagc agttcggacg
     4141 ggacggtcat ggtgaaggcc gaacggtcct ggttggtgga cgcgttgacg tcccgggcgc
     4201 cggcgcgccg gagggtctcc aggaagtcgg ggtgtctgcg ggtgcccagg aacatcaggt
     4261 gctccaggaa gtgcgcgaga ccgtggtggc cgggtgcctc gtgccgggaa ccgacgtcgt
     4321 accgcaggtg gacgtggagc ccgcgcaggg ccgggtcccg ctgggcgacc acggtcagcc
     4381 cgttcgccag gcgcgtggtg gacagcgggc cgtgcggggc gtcgtaccgt tccaccgctg
     4441 ctcagaccct ggcgtaggcg aagcgcacgg gcagggccag gcagtggccg ggatccagcg
     4501 cgagcaccag gcgctccttc gcgaggcggg ccagcgcacg ccggtcgccg gggtccgggg
     4561 cggccggggc cgcgtatctg cgcagcaggt gcccgtaggg ccggtccggg acggtgtggc
     4621 ggcgcggtgc ccgtgcgtcg cgcaggtcgt cgacgacgac gaagcccggt ccgcgccgca
     4681 gggtcagcag gggcgcgggc gggacgggcc aggccggtcc ggcgtcgccc cgcggcgggt
     4741 ccagatggtg cagcagctct gccggtacgt ccccggtgcc gccctcccag tagacccgca
     4801 ggccggtccc cgcggcctcg gtgagcaggt gcaggaaacg cacggtcgcg gcagggtcgg
     4861 tggtggagag gcggacggga cggttgatca ccaggccgcg catgcccgag cgcgcccagg
     4921 ccgccagcgt ctccctgccg ggggcttcct cgggcgagca gggcaccagg agggaggacc
     4981 gggtggtggt ccgggccggt tcactcatgg ccgagtccgg tgggcagggc cacgtaccgg
     5041 ccgtcctcgt ggaagagcca gcgccgctcc cgccactcct ccagcagtcc ggtcacccgg
     5101 tcctcggtcc ccgggatgcc ctgtgcggtc acctcgcggg tgacgcccgc ggcggagcgg
     5161 cccttcaggg tggcgcggaa ggccgcgacg gcgagcgggg tgcggagcac ctcctggacc
     5221 ggggtggggc tgcgctcgtc gacgatccgc agtgtgtccc cctcggggag cgccaccagc
     5281 cggcggcccc ggtggtgggc gcgccaggtg tccacggcgg cccgcaggcg gtccgcgacc
     5341 tcctcggaga tgccggcggg tctgctctcg aacacgtagc cgatgtcggc cacctcctcg
     5401 gcgggcagcc ggtagacctt ctgcagcagc ccggaggggc cgaggttctc caggcccagc
     5461 gcggggtcgt tgtagaaggg gctgaagcgg gtgaggacgg cccggtagac accctcgggc
     5521 ggggtgaggt gccagagccc cggcaactgc tcgatgatct gctcgtagtc ggcctccgtc
     5581 tccccgggga agccgtagag gaagttccag ccggggaaga cggcgacggt gcggctgtcc
     5641 cgcagcaggc gtacgttctg ccagccggtg acgcccttgc gcatcagccg gagcacatgg
     5701 gtgctcaggc tctcgatgcc cggctggacc tgggtgaccc cggcgtcggc cagcaccttg
     5761 agctggccca tcccgaggtt cgacttgatc tcgaagaaga gccgcaggtc ccagggctgc
     5821 tcggcgagct tcggcagcag gtcgcggagg tagcccatgt ccatgatgtt gtccgcgaag
     5881 acgacgtcga ggacctggtg gtcgcggacc gcgttggcga tctcggccag gacgcggtcg
     5941 gaggacttcg cccggaaggc catcagggag ccgttcaggc cgcagaaggt gcagtggtgc
     6001 ttctcgcccc accagcagcc ccgtcctccc tcgagctgga tcttcggctc cacgtccgcc
     6061 accgcccggg cggcccggaa ggtggcgaag tagccgctga ggtccgcctc gggaacggcg
     6121 tcgatgggaa gccccgccga cggctgctcg ttggcccgcg cccggccccc ggcgtcccgc
     6181 cagcacaggc cggggaccgc ggcgagccgt gccgccgccg gggcagcgcc cggctccgta
     6241 cgggccagca gccgcagcag cgcggggaag accgactccc cctcgccgcg caccacatag
     6301 tccaggaagg agaagttccg gtgcagcgcc tcgccctgca cgtcgtcgca gttggcgccg
     6361 cccatgaccg tgaccacccc gggagcccgt tccttgaggg cgcgggccag ggccagactc
     6421 ggcatgttct ggtcgaaggt gctggtcatc ccgaccaggt cgtacccgcc cgcggccagt
     6481 tcgccggcga gcgcgtcgac gaagccggag ctgagccggt acatctccac cgctgcccgc
     6541 agatcggccc cgctgccggt cgccgcggtg tggaaggccg acccgaccgg ttcctcgaag
     6601 ccgtacaggg cgggcgagaa gatccactca ccggtcgcca cgtagtagcc gtcgacgatg
     6661 cgcccgtagt cggcgctgcc gatggcgccc ccggtgcgct cgtggacgtg gtcggcccag
     6721 cggatgttgg cgtagacggt gtcgaccgcg tcgacctcct ccagcgcgcg ggcggccggc
     6781 gcgagggtgc tgatggccat cgagggcatg tcgagcgccg cccagggcat gcacaccagc
     6841 gccacccgca gcgtgcggac gggcccccgc tccggggctt cgggaaggcc gaggaactcc
     6901 gtcgtgggca tgggcctgct ccttcacacg cgggcgttga cgggcttggg caggtgcgtc
     6961 ccccggtagt ccgcgcgctc gatgccggca ccctcggtga acgcctcgtc gaaggacacg
     7021 tcccagacgt acgcggacca gaagtccgct ccgcggaagg ccgttcgccg gcaggtggac
     7081 tcgcgcaggt cggagtggcg gaggtcggtg cgccgcaggt cggcctcggt gaggtccgcg
     7141 ccgaagaggc tggcacggcg cagcgtcgct cccgagaggt cggcggagcg caggccggcg
     7201 cgggccaggt cggcgctctc cagccggctg cccgagaggt cggcgccgga gaggtccgcg
     7261 ccggtcagcc gggcccccgt caggtccgcg ccccgcaggt ccgcgccgcg caggtcggtt
     7321 ccggcgccgt ggccgcggag caggagccag ccgtcgacga gcgccagcgt gcgcaggccg
     7381 gtctcctcct tgacgacgag ggccagggtc cgcatgccca ggccggccgc ggcgacctcg
     7441 gccgcggtcc gcgccagggg cactccggcg gcgggcaggg gggaggcgag gaccgggtcg
     7501 gtgccggcgg gcccccgcag ccggccgtcc agcggcagca ggccgcagcc gccggggccg
     7561 gccgcgtcgt cgccgacctc ggccagcacc acatccagca ggctatgcac gggttctgct
     7621 cctctcgtca cccgtccggg gggcccggac gggttcgcct tccatgaaga agaagttctg
     7681 ggtgagccgg ccttccccgg gggcgtcgcc gaacagttcg gtgatgccgt ggaagaggcg
     7741 gccccctcgg aagacgacgc accggttgta ggccagctcc acctcgtgga gggtttccca
     7801 ccggtcctcc gaggcggtgt cccgcaggac gtaccgctcg tcgaactcct ccctgctccg
     7861 gcagccgaag cgggccagct caccgtccgc cgggacccgg tccaggccgg tggggaggtg
     7921 gcggtagaac cccagccctc cccgggcgtg ttcggccggc gagaggtaga ccacggccgt
     7981 ccagtcgacg aagtcgaggt gcacgcgggt ctgcccggcg tcggaccggg tcgcgatccg
     8041 gaacttgccg aacaccagct gccgggggtc gtggaagacg ggggcgccga cgatctccgc
     8101 caggcgccgg gcgtgcccct cggaggcgta ggccttgacg ctctcccggc cggggaagtt
     8161 cgccgcctcg ccgaagccgc ggtactcggc cgcgagggcc agctccctga cgcggtccgg
     8221 gtcctggtag aagccgtcga cgaccaggac gtcgccgccg agcgcgcgct cgacgcgggg
     8281 ggcggtcacc gcgccgccgc ttccgccggg gccggcatcc ggcgcaccgc gccggggacg
     8341 gaacggacct cgttgaagaa gaagttgtgg gtgatccgcg cgttggccgg acggtccccc
     8401 agcccgccga gcggcgcgtg gtagagctcg cagccgcgga agagcaccag ccggttgtag
     8461 accggggcga cccagtccgt cagctcccac ttgccgaggt cggccatgtc gcgccgggcg
     8521 acgccctcct cgaaggcgtc ggcgtcggcg aacccgagcg acctcgccac ccggtcgctg
     8581 ggcggccggc tgaaccccgt ctcccggtgc cggaagaacc cggtgcccgc ggcggcgggc
     8641 gcgccggggg tgaggtagac catgccggcc cagtcgaccg cggtgtcggc gtgcaccttg
     8701 gtggcccgcc cggtctcctc ggtgatcacc cggaagccgc cccaggtgag ccggtccccg
     8761 tccacgtgga ccgccgaccc cacgatccgc tcgatcgccc gctggagcgc gtccgtgctg
     8821 agcgccttgt tgctctgcca gcccgggtag ttgtaccggc tcgcgctctt gaagtcggag
     8881 cggagcgcgg cggcccgcac gctgtccggg tcggcgtaga agtcgtcgac gacgatcagt
     8941 ctgctgcgca tcacgaggcc ctctcttcat cgaagaagaa gcgctgggtc agacgtccgt
     9001 cggccgggcc ggtgccgaag cccgaactcg cccggtggaa gcgggtgccg ccgcgcagca
     9061 ggaccaggcg gttgtagacc atgctgacgc gggacatctc ctcccatgcc tccggccgta
     9121 ccttgtccgg gaaatagacg tccttcatcc agtgctcgcg gtcgtcgtag ccgagctcca
     9181 cggccttcgc gtcgtccggc gggcccagga ggccgctgtc gcggtgccgg aagaaggaca
     9241 ggccgccgtc gcaccggccg ggcgggacca ggtagacgat gcccgcccag tcggtgtcgt
     9301 cgtagtgggt ggtcagcggg acgttcgcgg actccccggt gaaggcgaac acgccgaaac
     9361 ccatcaccgc cgggtcgtac cgcacgcgga tgccgaggat ctcgccgaag gcttcggcga
     9421 ccccgcgccc ggcgaaggag ttgtaggtct cggcgtcgta ggtacggccc tcgtcggtct
     9481 tctgcggtga ccagtccccc ctttccaggg ccagggcgcg cacccggtcc gggtccgcgt
     9541 agaagtcatc gaccacctgc agtgtcttgt cgatcggact ctcctctctt ccctgtgacg
     9601 atgcggccgt ccccgaggcg gagccggagg aatccggcca gcagcagata cgccgcgccg
     9661 cttgccaggt aggggacccg cagggcgtcc cgcaacccga gtggtccggc ggcggcctcg
     9721 acgaggagtc cgcccaggag catgccgacg gcgctcattc cgaacgtcac cgtgcggaag
     9781 gtggcgttga cccggccgag cttggcgtcg ggcaccgcca gctgccgtac ggtcagcgtg
     9841 gtgacgctcc agagcgccac gccggcggag gcgagtgcgt acagcccgac gacgaccggc
     9901 acggccggta tcagaccgac gccgaggaag cacagcgcca tcgcccacag cgccgccgtc
     9961 agcgaacgct cgacgcccca ccggtccagc agccggcgcg cgtactgact gccggcgacg
    10021 cccccgaggg ccgcgcacga gagcagcagc gcgtagccga gggcgtcgag gccgagggtc
    10081 tcgcggacga agagcacctg gcccgcgagc atggtcgcgt agaagctgtt gaggaccacg
    10141 gcactggccg ccaggacgcg caggagcggg tcccgccaca ccaggtgcag gccggcgccc
    10201 agctccgccc ggaccgagcc gctcccggcg ggcgcgggcg gcggcgggtc gttcacgcgg
    10261 cgccgcatca gcaggagcgc cccggcggag gcaccgttga gcagggcgtt gcccaggaac
    10321 ggtacggcca gccccgattt gaggagcagg ccgccgagcg gccggcccac gaagtcgttc
    10381 gagaggatct ggctggcccg gacgtggccg ttggcccgtg ccaggccctg cccggggacg
    10441 agcagcggaa ccgcggtgtc ggcggcgacg ccgtaggcca cctcggtcgc tccgaagaac
    10501 agggcgaaga gcgccagcac ggccaccggt acgtcggtgg ccaggagcag cacccccagc
    10561 accagcatgg cggcggcccg cgcggcgccg gtgacggcca tcagcccgac cctgggcagc
    10621 cggtccacga gggcgcccat ggggagcgcg aacagcagcc acggcaggcg ctccgccatc
    10681 gcgaccagcg cgatggagaa ggcgttgtcg gtgaccgtgg ccgccgccca ggtcagcgcg
    10741 atgagcgtca tgccgtccgc gaggctgccc gccgtcagac aggaccagaa gagccagaac
    10801 cgtgacggca gcgacgactt ccggggagga gccggtgcgc tcatgaggcg gccgtcacgg
    10861 cactcgtccg cttcagcagg cggttcgtcc agggccactc gggcaccagc gggttggcgg
    10921 ccatggcgag ggcctggggg agagcggtcc tggtcagcca gtccggatgc tccacggcca
    10981 gcgactccgc ctcctcggcg atccagtcgc cgtaccaccc gagcgaggtg tccccgccga
    11041 acgtgagcgc ggccgcgacg gtgggcagca gggccgcggc ggggtgtccg cgccgggcga
    11101 gctccagggt cgtcgggacc gccacctccc ggcgcaggta gaactcccgg gtccccacgg
    11161 cggaggcgtc ggcaccggcg gcctcggcgt gggcccggac ctcggcgagc atctccggcc
    11221 agcgccgggc catttcggcg tccagctgct ccggggtgcg ggggaccgac ccgccggcgt
    11281 cgtcgtcctc gggcgggtcc gcggccacgc ggaagtccgc cgcgcgggcc agccgcagcc
    11341 gttgcagcgc cagcacggcc tcgtccgtgg gggagagccg ggcgccgcgg cccgcctccg
    11401 cgccgcggac cgttccggcg gggacgtcct cccgggtgtc ccggaggacg accgtcatgt
    11461 tgcggcggca ggagaggtag gcggcgtgcg gccagagggg ggccagcagg ccggcgagca
    11521 cgtgctgggg ggacggcggg gcgaggggcc gcaggtgttc gggcagtccc caggcgttca
    11581 gcagcgccgt gccgcccggc gcgacggcgc cgcgcacccg gcgccagaag ggctcggtga
    11641 gcaggaagtc cgggtacgac tcgccggcgt agatgtcgat cacgacgagg tcgtagcgct
    11701 cgctgccgtc gaggaaggcg gacgcgtcgg ccaccacggt gcggaagtcc gtcccgggga
    11761 agtgctgccg gaagagcgcg cgcgtcaccg tcaccatgtc cgggtcgagg tccacggcgg
    11821 tgacgcggct cccgggtgac gccgcgagca ggggacgcag cgatccgccg taccccaggc
    11881 ccagcacaca gaccgtgtcc gccgggccgg c
//
