LOCUS       NZ_CP023202            24199 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5336559
            Orig. end                         :: 5360758
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24199
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="20"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24199
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24199
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14199](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14199)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(26..697)
                     /gene="ribA"
                     /locus_tag="SXIN_RS22765"
     CDS             complement(26..697)
                     /EC_number="3.5.4.25"
                     /GO_function="GO:0003935 - GTP cyclohydrolase II activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ribA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191545.1"
                     /locus_tag="SXIN_RS22765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP cyclohydrolase II"
                     /protein_id="WP_019709266.1"
                     /transl_table=11
                     /translation="MTDSDVALRDSALAPGVERVAHVRLSTEHGEFLAVGYLDRIRGDE
                     QIALVYGDIEGEGALTRLHSECLTGDAFGSKHCECGDQLSAALRAIVAEGRGVLIYLQG
                     HEGRGIGLLAKLKAMALQAEGLDTVEANLALGLPADARDYRVAAEMLHDLGVRSVRLMS
                     NNPLKRDALLRHGIRIAEQVPLLIPPREENLAYLVTKRERFGHHLPHLDLDLDRAAAPQ
                     P"
     misc_feature    complement(740..756)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.9"
                     /tool="antismash"
     gene            921..1742
                     /locus_tag="SXIN_RS22770"
     CDS             921..1742
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059569.1"
                     /locus_tag="SXIN_RS22770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="creatininase family protein"
                     /protein_id="WP_095757440.1"
                     /transl_table=11
                     /translation="MSGSGTGLPASGLLPLDTTEDVGSRGAAVAVLPIGSFEQHGRFLP
                     LVTDTVVACAVAGEIAAAHPVRLLPPVTVSCSHEHADWPGTVSISAATLYAVVKDIAES
                     LRRSGVTNLVLVNGHGGNYVLRNVVQESAGSGTRMALFPGSGDWDAARERAGVVTSSRS
                     DMHAGEVETSILLHAHPELVRPGYETSDWLSDDRQHLLTLGMRPYTGSGVIGRPSMASA
                     EKGKQLLAGLVDSFGEYLSVLGAAERVPEPARPEPDRSGPRSGDGAGRGAL"
     gene            1802..>2473
                     /locus_tag="SXIN_RS32450"
                     /pseudo=""
     CDS             1802..>2473
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013989.4"
                     /locus_tag="SXIN_RS32450"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="RibD family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLGASEAWERLCGVRSEADAEAAGLVADADGRRRWPHASPGAALL
                     AERYLSLCLAGPRFTFAQLGQSLDGFIASRTGDADYVTGEEDREHLHRLRALADAVVVG
                     SGTAAADDPRLTVRACAGTNPVRVVLDPHRRVPPGLRVFQDGEAPTLWVVGAGDGEHGR
                     HGGHGRHGGPGGAGGGGRVDVLVLPDSAAFAPRRLVHELARRGLGRVLVEGGGVTVSRF
                     LH"
     gene            complement(<2651..3604)
                     /locus_tag="SXIN_RS32455"
                     /pseudo=""
     CDS             complement(<2651..3604)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527376.1"
                     /locus_tag="SXIN_RS32455"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lysylphosphatidylglycerol synthase
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIGGLAILAVLLWQLGTGAFLDGVRRLDAVTLLAALGLGLLTTVF
                     SAWRWCLVARGLGIRLKLGRAVADYYRSLFLNAALPGGVLGDVHRAVRHGRSSGDVGRG
                     VRAVVLERCAGQGVLVAVGVALLIAQPSAALAEAGRSVWRLVTAPGVPPALSAAGAAVL
                     LLVLRRRLRPGRAPEGNPDGASPAGPHGSRWARALRTTLAEARLGLLARRSWPGVVVSS
                     AVVLAGYLGMFLLAARAAGATAPAAELLPLMVLALLAMALPLNVAGWGPREGVTAWAFG
                     AAGLGAAQGLTVAVVYGLLSFAASLPGVGVLLAQWCA"
     gene            complement(3634..4695)
                     /locus_tag="SXIN_RS22780"
     CDS             complement(3634..4695)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983233.1"
                     /locus_tag="SXIN_RS22780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_107501172.1"
                     /transl_table=11
                     /translation="MPAETEPVTVRDTPAGGPATGGDPSGNPAVASPAGTGSLDGAGPG
                     TAAGDGAPRYAPEWLALRESADAAARAPRLLGPLVRHWAGGRDGEEGQPRQAGRPERRG
                     PLVIRDLGCGTGSMSRWLAPRLSGPQHWILHDHDPELLELAAERMPRTAADGSPVTVGT
                     EQGDATLLTAGVLAGTSLVTASALLDLLTREEVDALAASCAAAGCPALLVLSVAGRVEF
                     SPADPLDGEIADAFNAHQRRAVDGRRLLGPDAVTEAAEAFTRHGLTVRTEASPWRLGPG
                     DPAGPAGGGPALAAEWLRGWVGAAVAQRPELTEPAETYLRRRLESCAAGELRAVVHHSD
                     LLALPVPPAGGTP"
     gene            complement(4685..5827)
                     /locus_tag="SXIN_RS22785"
     CDS             complement(4685..5827)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174232.1"
                     /locus_tag="SXIN_RS22785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_095758157.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.4e-30,
                     bitscore: 104.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGDVADPSAPSGGNVYDLRVCRDLPRLGWQVHPHAVDGGWPRPG
                     PGARAELARVLREPADGSLVLLDGLVACAVPEIVVPEAERLRLAVLLHLPLGDETGLDP
                     ATAAELDAAERETLRAVPAVVATSQWAAGRLVEQHGLAPARVHAAAPGADIAPLAPGTD
                     DGPRGHGARGPDGAGSGADTGAPRLLCVASVTPRKGQHRLVEALAGVTDLPWSCHLVGG
                     LDHDPAYVTRLRKLIAELGLGDRVRLTGPRTGAALDASYAAADLFVLTSYAETYGMAVT
                     EALGRGVPVLATAVGGVPEAVGHTPDGCRPGALVPPDEPAVLTAALRRWLSEPGVRDRW
                     RTAARRRRDALAGWETTARNLAAVLEELRLRTELRRTHAC"
     gene            complement(5875..6273)
                     /locus_tag="SXIN_RS22790"
     CDS             complement(5875..6273)
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070497 -
                     6-carboxy-5,6,7,8-tetrahydropterin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTPS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431583.1"
                     /locus_tag="SXIN_RS22790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-carboxytetrahydropterin synthase"
                     /protein_id="WP_019709268.1"
                     /sec_met_domain="PTPS (E-value: 3e-23, bitscore: 80.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSVTVREHLMVAHSFRGEVFGPAQRLHGATFLVDATFRRTDLDA
                     DNIVVDIGLATSELGAVVGEFNYRNLDEVPEFAGVNTSTEYLAKVIADRLADKVHAGAL
                     GEGARGLSGISVTLHESHIAWASYERTL"
     misc_feature    6227..6242
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.43"
                     /tool="antismash"
     misc_feature    complement(6251..6264)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.56"
                     /tool="antismash"
     gene            complement(6485..7468)
                     /locus_tag="SXIN_RS22795"
     CDS             complement(6485..7468)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994224.1"
                     /locus_tag="SXIN_RS22795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding alcohol dehydrogenase"
                     /protein_id="WP_019709269.1"
                     /transl_table=11
                     /translation="MPRTARAFWLNSPGHGEIRDVTLPEPADGDVVVRALYSGVSRGTE
                     SLVFRGGVPESQHTAMRAPFQEGAFPAPVKYGYLSVGLVEEGPEHLLGRTVFCLYPHQS
                     RYVVPASAVTPVPDTVPAARAVLAGTVETAVNALWDAAPLVGDRIAVIGAGMVGCSVAA
                     LLARFPGVRVQLVDADSSRAAVAEALGTGFALPGDALGDCDLVVHASASEAGLARALEL
                     LAPEGTVLELSWYGDRRVALPLGEAFHSRRLTVRASQVGTVSPARASRRGYADRLALSL
                     GLLADPALDALVSGECAFEELPATLARIASGELPGLCHRVRYDPPA"
     misc_feature    complement(7551..7563)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.18"
                     /tool="antismash"
     gene            7729..8571
                     /locus_tag="SXIN_RS22800"
     CDS             7729..8571
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999462.1"
                     /locus_tag="SXIN_RS22800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_019709270.1"
                     /transl_table=11
                     /translation="MALSDLCETRLLRQETTAGAGAQILLLVLLDTVAGLGLAGWLTGL
                     AFTVGTWALLTRALHRSWPPRPFGPANAVTLARTTLVGGVTALVADSFTGPVPVGTLVA
                     LTAVALSLDAVDGQVARRTGTASPLGARFDMEADAFLILVLSLYDAMALGGWVLLIGAM
                     RYGFVAAARVMPWLNGPLPPSMARKTVAALQGVALLAAGSGLLPYAVAFGTVLGALALL
                     VWSFGRDIGTLWRFRVRDDDVPAGDNGGGVTERGTAARGRARRGAGAVVVRGTAAESV"
     gene            complement(8689..9909)
                     /gene="fxlM"
                     /locus_tag="SXIN_RS22805"
     CDS             complement(8689..9909)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676473.1"
                     /locus_tag="SXIN_RS22805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_019709271.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-37, bitscore: 128.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQHSTPQELRNRLVDQIVKAGLPGLYDARVEDAMRTVPRHDFIP
                     QASLELAYANQAVTIKDNPDPDALPLSCASQPDVVFFMLAQLDIQPGNNILEAGAGTGY
                     NAALMRHLTGPTGNVTTLDYHEDVAAHARQRLDATGFSDVRVLTRDGALGAPEYAPFDR
                     LIATVGVWDLPAAWWDQLAIGGRLVLPLRWRGLTRSIAFLREADSLRSESLATCGFLPM
                     IGQDGEREGYVDEDHLVKLYWDADQPIHALSLRKGLAEAKEHLLWTNVAVAPDEPLDGI
                     WLRLSAVDPATCRITVRPEAFAGAAGLRRPAIPALSPALVEGDSLAYLVLEPVDVQGSE
                     RYRLGAAGYGPAGQELAERLGVQLRAWDDDRTLPPSITAYPAGTPDEKMPGGHVIDKPS
                     VRLAITY"
     gene            complement(10001..11176)
                     /locus_tag="SXIN_RS22810"
     CDS             complement(10001..11176)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="SXIN_RS22810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_095757442.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-44, bitscore:
                     151.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGGTPVNPTAQAAPGWPQSLYAGAAGTTLLQAIKELVGVGDTEA
                     MRACAESMFRLPIMAGPEGFGLYEGAPAVAYVLTFTDTPSTERLLSVLDDHVRRMTTSR
                     LEAARARLESGRTAKTAEFDLISGLAGFGVYHLRRGNAGELHGILSHLVQLTEPIIVDG
                     QTLPGWWSISEARTAWPAGGHANFGLAHGITGPLALLATSSLRGYTVPGQERAMTRICQ
                     WLDDWKTGDGRSSHWPEWIDLQEQRRGSTAGTGPKRPSWCYGTPGIARALQLAGRALGD
                     TALQEHAEQALAGCLLDPQQLALLTDASLCHGWSGLIQATRRAAEDEKDGQLSDLLPRL
                     WAGLTTHIEEHGPPARSTLMEGTAGLDLVHLNDSKLATPERSWDLCLLLSG"
     misc_feature    complement(11084..11086)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11155..14199)
                     /locus_tag="SXIN_RS22815"
     CDS             complement(11155..14199)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676475.1"
                     /locus_tag="SXIN_RS22815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_039821486.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.4e-192,
                     bitscore: 639.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.3e-13,
                     bitscore: 47.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-26, bitscore:
                     91.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKHTRVYQHTGAALLRAAAAPLTALPSSWPDPHDTDAVSDWLRD
                     VCRQRVFADAIRQASGDLAARLNDIVSGRPVHPRQIRRAYLATVSYVLRATGRPTPFGL
                     FAGVAAAGIDRQPHVRWGDAHRAVIRADTEWLDDVCTRLESIPELLDRLSVILNSLAMP
                     RGDRLHVQHGGPRGASVRRSRVVRLIEKHTTRPVRVTTLLAELDRVFPEADPTRARALI
                     ASLMAQKFLLTNLRAPMTETDPLGHLAGELKAIDADSVPSAAGILDGLLAVQEAFREHN
                     TAPARDQHIAREAAVRNCRNVSAAARSPIAADLVLDADVRIPRSVVGQMERAADALLRL
                     TRQPAGQGVWRDYHAAFWERYGTGTLVPVKDVIDPVAGLGYPAGYPGSRRLAARPVVSE
                     RDGRLLAVAWEAATAGSREIVLTEELVDRIAGAPAVSDAAPSSVEMCARVHARDLQALQ
                     DGHFTVTVTPARSAGTLTSRFTPVATGSGLEEVYRQVPPTIEGALTAQLSFPGLYAHIE
                     NVARIPAYLPRAISLGEHRPAGEKVEVIDVDDLAVTATANRLYLVSRSRRRVIDPQVFH
                     AMALEKQPPLLARFLAHLTRAFGPAWTGFDWGPQAERLPFLPRVRYDKTILSPARWYLS
                     ADSLPPAKEDSGQWMDALTSWRKMWQCQGPVELRDDDRALRLMLDVPAHAAILREHLDR
                     NGQAVLTETPPEDGFGWIGGRVHEVAVPMTSTRPPSPNPLTGRLPVQRNSTLGPLPAAP
                     AAPWVNVQLYAHPDLHDELIAQDVATFAPRLQDHPDWWFIRYRTPHGADHIRLRVRAAS
                     AGQRSAHTEAIGTWAATLHNRGMISDLAFTTYTPEIGRYGSGRTLARAEAVFVADSYLA
                     ATALAGTTAPGAHGHALTAVGMVDIACGLLGDDEGLRRLAKRPVSAAAGRAATNQAIDL
                     IRAGNPAARGWSAALADAWHHRGEALARYRELLEDGMDVDTVLESLLHMHHNRMRGVNR
                     DDEKTCRRIARQTAIACLAWPEAHQ"
     misc_feature    complement(12349..12351)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(13486..13737)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SXIN_RS22815_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="4.30E-15"
                     /identifier="RREFam001.1"
                     /label="SXIN_RS22815"
                     /locus_tag="SXIN_RS22815"
                     /protein_end="238"
                     /protein_start="154"
                     /score="47.2"
                     /tool="antismash"
                     /translation="VILNSLAMPRGDRLHVQHGGPRGASVRRSRVVRLIEKHTTRPVRV
                     TTLLAELDRVFPEADPTRARALIASLMAQKFLLTNLRAP"
     gene            complement(14275..14457)
                     /locus_tag="SXIN_RS22820"
     CDS             complement(14275..14457)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676476.1"
                     /locus_tag="SXIN_RS22820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_019709274.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 6.8e-14, bitscore:
                     50.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPAAVLTKPIAETTTAPAEDPFDVQVEVVTEIDAEQLPQACGTG
                     DGCKSTCASSCASAV"
     CDS_motif       complement(14338..14457)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAPAAVLTKPIAETTTAPAEDPFDVQVEVVTEIDAEQLPQ"
                     /locus_tag="SXIN_RS22820_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14275..14337)
                     /prepeptide="core"
                     /locus_tag="SXIN_RS22820_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-2.10"
                     /molecular_weight="1670.8"
                     /monoisotopic_mass="1669.7"
                     /core_sequence="ACGTGDGCKSTCASSCASAV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAPAAVLTKPIAETTTAPAEDPFDVQVEVVTEIDAEQLPQ"
                     /leader_location="[14337:14457](-)"
                     /alternative_weights="1688.9"
                     /alternative_weights="1706.9"
     misc_feature    14539..14552
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(14574..14587)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.28"
                     /tool="antismash"
     gene            complement(14593..14772)
                     /locus_tag="SXIN_RS22825"
     CDS             complement(14593..14772)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676477.1"
                     /locus_tag="SXIN_RS22825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_039821488.1"
                     /transl_table=11
                     /translation="MSPEKPAAASLTTLARLWHVLRHPRWYARRCGFGTFQILVLPAVT
                     TGSLLTALYLGHPR"
     gene            complement(14904..15311)
                     /locus_tag="SXIN_RS22830"
     CDS             complement(14904..15311)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378927.1"
                     /locus_tag="SXIN_RS22830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_019709276.1"
                     /transl_table=11
                     /translation="MLEMDYDVTPLSVRIARVLVSAHLRLWGMEKLVDTGALVVSELLA
                     NVLHHARPDRDGRRSALITVTRTPDGVALCVHDDDPSLPQRRCAGDEDEDGRGLQLVSV
                     IADQFGVFRTPSGGKDVWLTLLSPREPKAAP"
     misc_feature    15510..15524
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.26"
                     /tool="antismash"
     gene            15545..16939
                     /locus_tag="SXIN_RS22835"
     CDS             15545..16939
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031332.1"
                     /locus_tag="SXIN_RS22835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_019709277.1"
                     /transl_table=11
                     /translation="MPRPEKQLTPDASPRDWFGHEVRYWRKKRGHSASSLGPLVQASPS
                     LIEKVEKGRASCRRDLAERLDEVLTTGGVLTRAWGMVSGESEKRRRETEKNAGPSMEGT
                     VQAHQGRILGRETSSPLGSTEPVDRRAFLANSSLAAIASIDLAALVASTTPHEPPTKIR
                     PKDITAVLSVAEDIHRRDNAHGGGGLVGVLAGRAMEWAVRLLTVPCPEQLRAPLYTAVA
                     RLGVVVGASRFDAYAHDDARIAFKISADCAEEANDWHLRAKVFSFLARQAVWIGDPDTG
                     LTYAEKGLVRADRLTPTIQAMLHTARARAFGKMGDIGGATAAVGAADDAFARSNPQDDP
                     PWMAYYNEAQHDGDTAHALYDLVLLKDQNPGQASRRFETAIEGHDDAYARSRAISGTKL
                     ASLLMAKGDPQQATAIGHQALTDAGHLTSRRAADDLKELNRFAARHRRTPEVAYLRERI
                     AATLQA"
     misc_feature    15650..15652
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16936..17820
                     /locus_tag="SXIN_RS22840"
     CDS             16936..17820
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031333.1"
                     /locus_tag="SXIN_RS22840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_019709278.1"
                     /sec_met_domain="APH (E-value: 7.9e-23, bitscore: 80.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTISAHASSAVLAAACSAAGLDPSAAEPIRIAENEIWRLPGQRAI
                     VRIARPGQWAAAVREVSVAQWLADNDVPAVRALPVDQPVEVSGRPVTFWEELPAHTNGT
                     VRDVVQLLKRLHPLPVPDFPLGDLDPFVRVSERIDAATSLTEYDRSWLRQRREELQRQW
                     IRRPSGLPDCVVHGDAWVGNVARTARGPILLDFERVSVGPPEWDLVSTAVKLTTTGAVS
                     PPEYAEFCALYGVDVTEREGYELLSSARELRMATYAAQHAATRPEWTKEAQYRVDCLRG
                     RRGPRPWKWTGIM"
     gene            <17824..18888
                     /locus_tag="SXIN_RS22845"
                     /pseudo=""
     CDS             <17824..18888
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016051853.1"
                     /locus_tag="SXIN_RS22845"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="YAATVEVVADLGRADVDRRNFLAGVPFAALAGVGPSRDWLMSTLD
                     HSREPGPRVRLEDVTAVKNMFSEFQRMDVLQGGGSGRLILAEYMNHHVYPLLRRTYSED
                     VRRALCEAAAEQTYLLGWMAYDNGEHGVAQRYLIQSLRLAEESGNAALGSHVLAGMADQ
                     ATLHGDPIEGRRLAQAGRLGLSHVDSPACLADLWCLEARALASLNDKAAAVRAVVESER
                     AYDRAGSGDQPEWAAFIDPAYLHGEHANTFRDLGDAKSAEEHARKSIGHARSQRRARRG
                     AMSQAALAVSHLQRKDLEAAHAAGVRTLNLTRQVKSSRAVEAVYDIQRRMRPFGGHRLV
                     ADFNERVRELTAAA"
     gene            complement(18967..21282)
                     /locus_tag="SXIN_RS22850"
     CDS             complement(18967..21282)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999808.1"
                     /locus_tag="SXIN_RS22850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfatase"
                     /protein_id="WP_192883621.1"
                     /transl_table=11
                     /translation="MPLSRQLPTTDNATKEDGPAPDDSRERTPDDTTTADPDRAAATDT
                     DRGTATGHGDTAAGGTDGRDAAGPGADDAPAAAGTDPGGTGAGDQRPGGDTAPAGDRAR
                     AGDEADHGPEQPSAAEESTAEESAPAGRPAGTENPAVGPGTVNPADEPAPARTPDGPAG
                     GASEGSRPAGTPRRPWRRGPHGRWRAGHPAAARVLTYGTTALAVLLVFTALVMPNGLSR
                     FTPFAFTRLPGEAVVAAAVLLFLPPRPRRWVAALSGAGLGLLLVLKFVDIGFYSVLSRP
                     FDLVLDWILFEDGHSFLESTVGGTAATAAVIGAVTLAAAVPVLMTLAVIRLSEILVRHR
                     ATATRTTFVVAIVWITCSAIGLQIGSTPVASSAAAKLVKDRVKRVEAGIEDERKFARVA
                     AVDDFGDTPPDELLTALRGKDVLFAFIESYGRVAIDENPEMSRLMSAALAEDTDRLDKA
                     GFSSRSGFLRSPTTGAGSWLAHSTLWSGLWVDNQRRYRTVTASDRLTLTGAFQRSGAWR
                     TVGMMPGVTRAWPEGKFYDFDAIYDSKELGYQGPKFSWTPVPDQYTLSAFERLERAKKD
                     RDPLMAGIILATSHNPWAPIPRMIGWDEVGNGSVYHAMKEEGKDPEEVWKDPEQVRTEY
                     RRAVEYSMDSLVSYLEEYGDEDTVLVVLGDHQPVPTVAGEGASRDVPISIVARDEAVLD
                     RISDWEWDEGLKPGPDAPVWRMDTFRDRFLTAYGPEAGALSASQPESDADADADTEADA
                     DTEADTDKNADPDKAAKR"
     gene            21625..22083
                     /locus_tag="SXIN_RS22855"
     CDS             21625..22083
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538338.1"
                     /locus_tag="SXIN_RS22855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="archease"
                     /protein_id="WP_019709281.1"
                     /transl_table=11
                     /translation="MDRTEARGRPRASGHRTVPHTADLRVEAWAETAERCIAEAVRAAV
                     ESFADVSGAVAVAERTFEVTAATDEDLLVSVLDEAVYRLDADGEIPLETVVGPIRGGEG
                     GRAATVRCRMADASRTPLVGAVPKAVSLHDLRLRGDSGEWACAVTLDV"
     gene            22194..23621
                     /locus_tag="SXIN_RS22860"
     CDS             22194..23621
                     /GO_function="GO:0008452 - RNA ligase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557724.1"
                     /locus_tag="SXIN_RS22860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RtcB family protein"
                     /protein_id="WP_019709282.1"
                     /transl_table=11
                     /translation="MEIVLTEETPYRFRIEEREAMRVPGVVFASRELLPQAAGDKALEQ
                     VANVATLPGVVRASYAMPDVHWGYGFPIGGVAATDIDEGGVVSPGGVGFDISCGVRLLA
                     AGTTRAELDPGGFERLMDILGRTVPRGMGRGGLWELPGPDAMDDLLVDGARYAVEHGHG
                     VPRDLERCEDSGALEGAAPGEVSRRAVERGLGQVGSLGSGNHFLEVQAVGHLYDPEAAA
                     VFGLRPDQVCVMIHCGSRGLGHQVCTDHVKVMDRALHRYGIRLPDRQLACAPVDSAPGR
                     NYLGAMAAAANYGRANRQLLSEAARRAFTTALGTGLDLVYDISHNMAKVETHEVDGRPR
                     RLCVHRKGATRALPPGDPDLPEDLAEAGQPVLVPGTMGTASYVMTGLPGNDAFHSACHG
                     AGRVMSRHQALRAVRGERLRADLESKGVAVRPSSWRGLAEETPEAYKDVDVVADVTEGA
                     GLARLVARLVPLGVVKG"
     gene            complement(23834..24154)
                     /locus_tag="SXIN_RS22865"
     CDS             complement(23834..24154)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SXIN_RS22865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019709283.1"
                     /transl_table=11
                     /translation="MRKLQKAAIVMAMLGTVGIFGTGTAAAQSDIQSDRGQIRYEQSYD
                     QERYTEHRGRGRGHGHGRGHGRWGHGRGHGHGHWDRGRGHHRGHWGHGRGHHRGHWGHG
                     RR"
ORIGIN
        1 acggaccggg gagcggggcc ggcggtcagg gctggggagc ggccgcgcgg tccaggtcca
       61 ggtccaggtg ggggaggtgg tgcccgaagc gttcgcgctt ggtgaccagg tacgccaggt
      121 tctcctcgcg cggcgggatc agcagcggga cctgttcggc gatcctgatg ccgtggcgga
      181 gcagggcgtc gcgcttgagg gggttgttgg acatcaggcg gacggagcgc acccccagat
      241 cgtgcagcat ctccgccgcc acccggtagt cgcgggcgtc ggccgggaga ccgagggcga
      301 ggttcgcctc cacggtgtcg aggccctccg cttgcagggc catcgccttg agcttggcca
      361 gcaggccgat gccgcgcccc tcgtggccct ggaggtagat gagaacgccc ctgccctcgg
      421 ccacgatggc gcggagcgcg gcggagagct ggtctccgca ctcgcagtgc ttcgaaccga
      481 aggcgtctcc ggtcaggcac tccgaatgca ggcgggtgag ggcgccctcg ccctcgatat
      541 cgccgtatac cagcgctatt tgttcgtcgc cgcgaatgcg gtccaggtag ccgacggcga
      601 ggaattcgcc gtgctcggtg gaaagccgga cgtgtgccac gcgttcgaca cccggagcga
      661 gagcactgtc gcggagcgcg acatcactgt ctgtcatggc tcgatcctat cggtaagacc
      721 ctggcggtgg aatcggaaac ggtgagaaag tatcaactgg ttttgttgtt cgtcacgttc
      781 ggtcgttggg ttcgtgattt ccgcgtaggc tgctcgggtt gacggcgtgc ggtgggtgtt
      841 ccgtgtgctc cgggtccgtc ccggacggcg gttccgccgc ggccgtgtgt gtcggagaaa
      901 tactgaaagg gccgggaaac atgagtggtt cggggacggg gctgccggct tcggggctgt
      961 tgccgctgga cacgacggag gacgtgggga gccgcggagc cgccgtcgcc gtgctcccca
     1021 tcgggagttt cgagcagcac ggccgctttc ttccgctggt cacggacacg gtggtggcct
     1081 gtgccgtcgc cggggagatc gcggcagcgc acccggtacg gctgctgccg ccggtgacgg
     1141 tctcctgctc gcacgagcac gccgactggc ccgggacggt gagcatttcc gccgccacgc
     1201 tctacgccgt cgtgaaggac atcgcggaat ccctccgccg ttccggggtc acgaatctcg
     1261 tcctggtgaa tgggcacggc ggaaactatg tgctgcgcaa cgtcgttcag gagtccgccg
     1321 gcagcggaac ccgcatggcg cttttcccgg ggtcgggcga ctgggacgcc gcacgcgagc
     1381 gggcgggtgt ggtgacctcc tcgcgcagcg atatgcacgc gggcgaagtg gagacctcca
     1441 tcctgctgca tgcgcatccg gagctcgtgc gccccggata tgagacctct gattggctct
     1501 ccgacgaccg tcagcatttg ctcactctcg gtatgcggcc ttacaccggt tccggtgtga
     1561 tcggccggcc ctcaatggct tcggcggaga aagggaagca attgctggcc ggactggtgg
     1621 attccttcgg ggaatacctt tccgtgctgg gcgcggcgga acgggttccg gagcccgcgc
     1681 ggccggagcc ggaccggtcc gggccccggt ccggtgacgg cgccgggcgg ggggcgctgt
     1741 gaacgcgggg gacgcgggcc gcggcgcgga gcgcggcgga gagccgggtg cgggtgcggg
     1801 tgtgctcggc gcatcagaag cctgggagcg gttgtgcggg gtccggagcg aggcggacgc
     1861 cgaagccgcc ggactggtcg cggacgcgga cggccggcgc cgctggccgc acgcctcgcc
     1921 cggggcggcc ctcctcgccg agcgctatct gtccctctgc ctcgccggcc cccgcttcac
     1981 cttcgcgcaa ctggggcaga gcctggacgg gttcatcgcc agccgcaccg gcgacgccga
     2041 ctacgtcacc ggcgaggagg accgggagca tctgcaccgc ctgcgcgcgc tcgccgacgc
     2101 ggtggtcgtc ggctccggca ccgccgccgc ggacgatccc cggctgacgg tccgcgcctg
     2161 cgcgggcacc aacccggtac gggtcgtcct cgatccgcac cgccgtgtgc cgccgggact
     2221 ccgggtgttc caggacggcg aggcgccgac cctgtgggtg gtgggcgccg gcgacggcga
     2281 gcacgggcgg cacggcgggc acgggcggca cggcgggccc ggcggcgcgg gcggcggcgg
     2341 ccgggtggac gtgctcgtcc tcccggacag cgccgcgttc gccccccgcc gcctggtgca
     2401 cgagctcgcg cggcgcgggc tcggccgcgt cctggtcgag ggcggcgggg tcaccgtgtc
     2461 gcgcttcctc cacgaggagg cgctgcaccg gctctacgtc accgtggcgc cggtcctcct
     2521 cggggacggc gtcccggggc tccggttcac cggcccggag ctgatgcgcg acgcgctccg
     2581 cccgccggtc cggcgagccg tcctcggcga ggacaccctc ttcgaactcg acctgcgggc
     2641 gccgcagccc ggcgcaccac tgggccagca gcacaccgac accgggcagg ctcgcggcga
     2701 aggacagcag tccgtagacg acggcgacgg tcaggccctg ggcggcgccc aggcccgcgg
     2761 caccgaacgc ccacgcggtg acgccctccc ggggacccca gccggcgacg ttcagcggta
     2821 gcgccatcgc gagcagcgcc agcaccatca ggggcagcag ctcggccgcc ggggccgtcg
     2881 ctccggcggc ccgggccgcc agcaggaaca tgcccagata gccggccagg acgacggccg
     2941 acgagaccac cacgcccggc cagctgcggc gggccagcag cccgaggcgc gcctcggcca
     3001 gcgtggtgcg cagggcgcgg gcccagcgtg agccgtgcgg ccccgcgggg gaagctccgt
     3061 ccgggtttcc ctccggggcg cggcccggcc gcaggcggcg ccggaggacg agcagcagga
     3121 ccgccgcacc ggccgcggag agcgccggcg ggacgcccgg tgccgtgacc aggcgccaga
     3181 cggaccgccc cgcctccgcc agtgccgcgg acggctgcgc gatcagcagc gccacgccca
     3241 ccgccaccag cacgccctgc ccggcgcacc gttcgaggac gaccgcgcgg acgccccggc
     3301 cgacgtcgcc ggagctgcgc ccgtgccgca ccgcgcggtg cacatcgccc aggacaccgc
     3361 cgggcagcgc cgcgttgagg aacagcgagc ggtagtagtc ggcgaccgcg cggcccagct
     3421 tgagccggat gcccaggccc ctggccacca ggcaccagcg ccaggcgctg aacacggtgg
     3481 tcagcaggcc caggccgagc gcggccagca gcgtgacggc gtcgagccgc cgcacgccgt
     3541 ccaggaaggc gccggtcccc agctgccaca gcaggacggc gaggatggcg agaccgccga
     3601 tcatgccgag gcggttccgg agcgcgtgcg ggatcacggc gtaccgcccg ccggggggac
     3661 gggaagggcc agcaggtcgc tgtggtggac gaccgcccgc agctcgccgg ccgcgcacga
     3721 ctccagccgg cgccgcagat acgtctccgc gggctccgtc agctccggcc gctgtgcgac
     3781 ggcggcaccc acccagcccc gcagccactc ggcggccagc gccggcccac caccggcggg
     3841 gccggcgggg tcgccggggc ccagccgcca cgggctggcc tcggtccgca cggtcagacc
     3901 gtggcgcgtg aacgcttcgg cggcctccgt gacggcgtcg gggccgagga gccggcggcc
     3961 gtccacggcc cggcgctggt gggcgttgaa ggcgtcggcg atctcaccgt ccagcgggtc
     4021 ggccggggag aactcgaccc gtccggcgac cgacagcacc agcagcgccg ggcagccggc
     4081 ggcggcgcag gacgcggcga gcgcgtccac ctcctcgcgg gtcagcaggt cgagcagggc
     4141 ggaagcggtg acgagcgagg tgccggcgag gacgccggcg gtcaggagtg tcgcgtcccc
     4201 ctgttcggtc ccgaccgtga cggggctgcc gtcggcggcc gtgcggggca tccgctcggc
     4261 ggccagctcc agcagctccg ggtcgtggtc gtggaggatc cagtgctgcg gcccggacag
     4321 ccggggcgcg agccagcggc tcatggagcc ggtgccgcag ccgaggtcgc ggatcaccag
     4381 cgggccccgc cgctccggac ggccggcttg ccgcggctgt ccctcctccc cgtcccgtcc
     4441 gcccgcccag tgccggacca gcgggccgag cagccgcggc gcgcgggcgg cggcgtcggc
     4501 gctctcccgc agggccagcc actcgggggc gtagcggggc gccccgtccc cggccgcggt
     4561 gccgggaccg gcgccgtcga ggctcccggt accggccggg ctcgccacgg ccgggttccc
     4621 ggacgggtct ccgcccgtgg ccgggccgcc ggccggggtg tcgcgcacgg tcacgggctc
     4681 ggtctcagca ggcatgggtc ctccggagtt ccgtacggag ccggagctcc tccagcaccg
     4741 cggccaggtt ccgcgcggtc gtctcccagc cggccagggc atcgcgccgg cgccgcgcgg
     4801 cggtccgcca ccggtcgcgc acgccgggct cggagagcca gcgccgcagg gcggcggtga
     4861 gcaccgcggg ttcgtccggc ggtacgaggg cgccgggccg gcagccgtcg ggtgtgtggc
     4921 cgacggcctc cgggacgccg ccgacggccg tcgccaggac ggggacgccg cgtccgagcg
     4981 cctcggtcac cgccatgccg tacgtctcgg cgtacgaggt cagcacgaac aggtcggcgg
     5041 cggcgtaact cgcgtccagg gcggcgccgg tgcgggggcc ggtgagccgg acccggtcgc
     5101 cgaggccgag ttcggcgatc agcttccgca gccgggtgac gtaggcgggg tcgtggtcca
     5161 ggccgccgac gagatggcag ctccacggca ggtcggtgac gccggccagg gcctcgacca
     5221 gccggtgctg gcccttgcgc ggggtcaccg aggcgacgca cagcagacgc ggggcgcccg
     5281 tgtccgcgcc gctcccggca ccgtccggtc ctctggcgcc gtgtccgcgc gggccgtcgt
     5341 ccgtgcccgg cgccagcggg gcgatgtccg ccccgggcgc ggcggcgtgg acccgggcgg
     5401 gcgcgagccc gtgctgctcc accagccggc cggcggccca ctggctggtg gcgacgacgg
     5461 ccggcacggc ccggagggtc tcccgctcgg cggcgtccag ctcggcggcc gtcgccgggt
     5521 cgagcccggt ctcgtcgccc agcggcaggt gcagcagcac ggcgaggcgc agccgttcgg
     5581 cctccgggac gacgatctcg ggcacggcgc aggcgaccag cccgtcgagc aggacgaggc
     5641 tgccgtccgc cggttcccgc aggacgcggg ccagttcggc gcgcgcgccg gggcccggcc
     5701 gcggccagcc gccgtcgacg gcgtgcgggt ggacctgcca gccgaggcgg ggcaggtcgc
     5761 ggcagacgcg gaggtcgtag acgttgccgc cgctcggcgc ggacgggtcg gccacgtctc
     5821 ccggcatcac cacgtgcacc gagcgcgcgg gcggggtggt ggtggcggcc ccgttcacag
     5881 cgtccgctcg taactcgccc aggcgatgtg ggattcgtgc agggtgacgg agatgccgct
     5941 caggccgcgg gcgccctcgc ccagggcccc ggcgtgcacc ttgtcggcca gccggtcggc
     6001 gatgaccttg gccaggtact ccgtcgaggt gttgacgccg gcgaactcgg gcacctcgtc
     6061 gagattgcgg tagttgaact ccccgaccac ggcgcccagt tcactggtgg ccaggccgat
     6121 gtcgacgacg atgttgtcgg cgtccaggtc cgtacggcgg aaggtggcgt ccacgaggaa
     6181 cgtcgcgccg tgcagacgct gcgcgggtcc gaagacctcg ccgcggaagc tgtgagcgac
     6241 catcaggtgc tcacggacgg tgacgctgaa caacgaccga cctccaggtc tctgggctgt
     6301 gcggcccgct gccgggccgt gccatgcagt acggccggag cgtaactcct gttcaaagcc
     6361 cgggccgcgg agaattccgg cgcgctgcgg cggcggtggt gccgcgtgcg gccggtgacg
     6421 cgggggacgg cgcacgcggg cggctcacgc ggggcggctc atcccggccg gcgcgcggga
     6481 cggctcacgc gggtgggtcg taccggacgc ggtggcacag cccggggagt tcgcccgagg
     6541 cgatccgggc gagcgtggcc ggcagttcct cgaaggcgca ttcgccggag acgagggcgt
     6601 cgagggcggg gtcggcgagc aggccgaggg agagcgcgag ccggtcggcg tagccgcggc
     6661 gggaggcgcg ggcgggggag accgtgccca cctggctggc gcgcacggtc agccggcggg
     6721 agtggaaggc ctcgccgagc ggcagggcga cccgccggtc gccgtaccag ctcagctcca
     6781 ggaccgtgcc ctccggggcg agcagttcca gcgcccgcgc gagcccggcc tcgctggcgc
     6841 tggcgtggac gacgagatcg cagtcgccca gggcgtcccc cgggagggcg aacccggtgc
     6901 ccagcgcctc ggcgacggcg gcgcgggacg aatcggcgtc gacgagctgg acgcggacgc
     6961 ccgggaagcg ggcgagcagg gcggcgacgg agcagccgac catgccggcc ccgatgacgg
     7021 cgatccggtc gccgaccagc ggcgccgcgt cccacagggc gttcaccgcc gtctccaccg
     7081 tgccggcgag cacggcccgg gcggcgggga ccgtgtccgg caccggggtc acggcgctcg
     7141 ccgggacgac gtaccggctc tggtgcgggt agaggcagaa gaccgtacgg ccgagcaggt
     7201 gttccggccc ctcctcgacg aggccgacgc tgagatagcc gtacttgacg ggagcgggga
     7261 acgcgccctc ctggaagggc gcccgcatgg cggtgtgctg gctctccggc acaccgccgc
     7321 ggaagacgag gctctccgtg ccgcggctga cgcccgagta gagcgcgcgc acgacgacgt
     7381 cgccgtcggc cggctcgggc agggtgacgt cccgtatctc cccgtggccg ggcgagttga
     7441 gccagaaggc gcgggcggtg cgcggcatcg gcgtcctcct ggtgaacgct gggctgctgg
     7501 ctcacgttat tgaacgcgag gccgcacacg gtacgcggcg gtccgactct gtcacagcgt
     7561 cacctcccgg ccggacccgg ccgggaccgg ttcgcacctc cgcaccggca cggcgccggg
     7621 agcggaacgc ggaccggcgg cggacacgga acacagcaca agcacacagc cgacaagcac
     7681 acagcacaag cacacagccg acaagcacac acagcgggag gatgcgcggt ggccctgagc
     7741 gacctatgcg aaacgaggct cctgcgccag gagacgaccg cgggggcggg cgcgcagatc
     7801 cttctgctgg tccttctcga cacggtggcc ggactggggc tcgcggggtg gctgacgggc
     7861 ctggcgttca cggtcggcac ctgggccctg ctcacccgcg ccctgcaccg gtcctggccc
     7921 cccaggccgt tcgggccggc caacgccgtc accctggccc gtacgacgct cgtcggaggg
     7981 gtgaccgcgc tcgtcgcgga ctccttcacc ggaccggtgc cggtggggac gctcgtcgcg
     8041 ctcaccgcgg tggcgctgag cctggacgcg gtggacgggc aggtggcccg gcgcaccgga
     8101 acggcctccc ccctcggagc ccgcttcgac atggaggccg acgccttcct gatcctggtg
     8161 ctcagcctct acgacgccat ggccctgggc ggctgggtgc tgctgatcgg cgccatgcgc
     8221 tacggcttcg tcgcggcggc ccgggtgatg ccgtggctga acgggccgct cccgccgagc
     8281 atggcgcgga agacggtggc cgcgctgcag ggcgtggcgc tgctcgcggc cggctccgga
     8341 ctcctcccgt acgcggtcgc gttcggcacg gtgctgggag cgctggcgct gctggtgtgg
     8401 tcgttcggcc gggacatcgg gacgctgtgg cggttccggg tccgggacga tgacgtcccg
     8461 gccggggata acggcggcgg cgtgacggag cggggtacgg cggcacgggg cagggcccgc
     8521 cggggtgccg gggccgtggt cgtacggggc acagcggcgg agagcgtctg agaccggatt
     8581 caccgggttg tgatcttccg aggtcagggc atgtagcggt ggatgtccgc cacgacgcgg
     8641 cagtggccgc attgttgcgc cgactgcccc gccaggtgga ggggagaatc agtacgtgat
     8701 ggccaagcgg acggatggct tgtcgatgac gtgtccgccg ggcatcttct cgtcgggggt
     8761 tcccgccggg taggcggtga tcgacggtgg cagggtgcgg tcgtcatccc aggcgcgcag
     8821 ctgcacgccc agtcgctcgg ccagttcctg gccggccggc ccgtacccgg cggcgcccag
     8881 ccgataccgc tcgctgccct gaacgtccac cggttcgaga accaggtagg ccagggagtc
     8941 gccttcgacc agggcagggc tcagtgcggg gatggccggg cgacggaggc cggcggcgcc
     9001 ggcgaaggcc tcggggcgga cggtgatgcg gcaggtcgcc ggatccactg cgctgaggcg
     9061 gagccagata ccgtcgaggg gttcgtccgg tgcgacggct acgttggtcc acaagaggtg
     9121 ttccttcgcc tcggccaggc ccttgcgcag gctgagcgcg tggatgggct ggtcggcgtc
     9181 ccagtacagc ttgaccaggt ggtcctcgtc gacgtagccc tcacgttcgc cgtcctggcc
     9241 gatcatcggc aggaagccgc aggtggccag ggactccgag cgcagggagt cggcttcgcg
     9301 gaggaaggcg atgctgcggg tcaggccgcg ccagcgcagc ggaagtacca ggcggccacc
     9361 gatggccagc tgatcccacc atgctgcggg caggtcccat acgccgacgg tggcgatcag
     9421 ccggtcgaac ggcgcgtatt cgggggctcc gagggcgccg tcgcgcgtga ggacccgcac
     9481 gtcgctgaag ccggtcgcgt cgagccgctg ccgcgcgtgg gcggcgacgt cctcgtggta
     9541 gtccagcgtg gtgacgttcc cggtggggcc ggtgaggtgt cgcatgagcg cggcgttgta
     9601 gccggtgccc gcgccggctt ccaggatgtt gttgcccggc tggatgtcca gctgggcgag
     9661 catgaagaac accacgtcgg gctgtgaggc gcagctgagg ggcagggcgt cggggtccgg
     9721 gttgtccttg atcgttacgg cctggttggc gtaggccagt tccagagacg cctggggaat
     9781 gaagtcgtgc cgggggaccg tgcgcatcgc gtcctcgacc cgggcgtcgt agaggcccgg
     9841 gaggccggcc ttcacgatct ggtcgaccag gcggttgcgc agttcctggg gagtgctgtg
     9901 ctgagtcata catgtccttc cgggagcgcc cggctcgtcc tggcggagtg cgggcagagc
     9961 ttagctgcgt cgtggtggtg ggaagtggtg gtgaatcggg tcagccgctc aacagcaaac
    10021 agagatccca actcctctcg ggggtggcga gcttggagtc gttgaggtgg accaggtcca
    10081 gtcccgcggt gccctccatg agcgtggagc gggccggtgg gccgtgctct tcgatgtgcg
    10141 tcgtgagccc ggcccagagt cttgggagca ggtcggagag ctgtccgtcc ttctcgtcct
    10201 cggcagcgcg tcgggtcgcc tgtatgagcc cggaccaccc gtggcacaag gaggcatcgg
    10261 taagcagggc gagctgttgc gggtccagca ggcatccggc gagtgcctgc tccgcgtgct
    10321 cttggagcgc ggtgtcgccg agcgcgcgcc cggcgagctg cagcgcacgg gcgatccccg
    10381 gagtgccgta gcaccacgac ggtcgcttcg ggcccgtgcc cgcggtactg ccgcgtcgct
    10441 gctcctgcaa gtcgatccac tccggccaat gggaggagcg cccgtcgccg gtcttccagt
    10501 cgtccagcca ctggcagatg cgagtcatgg cgcgttcctg gccgggcacg gtgtaaccgc
    10561 gcaaagagga ggtggcgaga agcgcaagag gcccggtgat gccgtgggcg agaccgaagt
    10621 tggcgtgccc gccggccggc cacgcggtcc gcgcttcgct gatgctccac cagccgggca
    10681 gtgtctgccc gtcgacgatg atgggctcgg tcaactggac gaggtgggac aggatgccgt
    10741 gcagctcacc ggcgttgccc cggcgcaggt ggtagacgcc gaagccggcc agtccgctga
    10801 tcaggtcgaa ctcggccgtc ttcgcggtcc tcccgctctc cagccgggcg cgggcggctt
    10861 ccagccgcga ggtcgtcatg cgccgtacat ggtcgtcgag gacagacagg agccgctcgg
    10921 tggagggggt gtccgtgaag gtgaggacgt aggcgactgc tggggcgccc tcgtacagcc
    10981 cgaatccctc ggggcccgcc atgatcggca aacggaacat ggactcggcg catgctcgca
    11041 tcgcttccgt atcgcccacg cccacaagct ctttgatcgc ttgtaagagg gtggtgccgg
    11101 cggctcctgc gtagagggac tgcggccagc cgggcgctgc ctgggccgtg gggttcactg
    11161 gtgtgcctcc ggccatgcga ggcacgcgat ggcagtctgg cgggcgatgc ggcggcaggt
    11221 cttctcgtcg tcgcggttga cgccgcgcat ccggttgtgg tgcatgtgca gcagcgactc
    11281 cagcaccgta tcaacgtcca taccgtcctc cagaagctcg cggtagcggg cgagggcctc
    11341 accgcggtgg tgccacgcgt cggcgagggc ggcggaccag ccgcgtgcgg ctgggtttcc
    11401 ggctcggatg agatcgatgg cctggttggt cgcagcgcgt ccagcggcgg ctgataccgg
    11461 gcgtttggcc agccggcgca ggccctcgtc atcaccgagc aggccgcaag cgatgtcgac
    11521 catgccgacg gccgtgagcg cgtgaccgtg ggcgcctggg gctgtggtgc ctgcgagggc
    11581 cgtggctgcg aggtacgagt cggcgacgaa cacggcttcc gcgcgggcca aggtgcgacc
    11641 gctgccgtaa cggccgattt cgggggtgta ggtggtgaac gccaggtcac tgatcatgcc
    11701 gcggttgtgc agtgtcgccg cccaggtgcc gatggcttcg gtgtgggcgc tgcgctggcc
    11761 ggcgctcgcg gcacgaacgc ggaggcggat gtggtccgca ccgtgtgggg tccggtatcg
    11821 gatgaaccac cagtcagggt gatcctgcag acgtggggcg aaggtggcca cgtcctgggc
    11881 gatcagctcg tcatggagat cggggtgtgc gtacagctgc acgttcaccc agggcgcggc
    11941 gggtgcggcg gggagggggc cgagcgtgct gttgcgctgc acgggcaggc gaccggtgag
    12001 gggattgggt gagggtggcc gggtgctggt catgggcacg gccacctcgt ggacacggcc
    12061 gccgatccag ccgaatccgt cctccggcgg tgtctcggtg agtacggcct ggccgttacg
    12121 gtcgaggtgc tcccgaagga ttgcggcatg tgcgggcacg tcgagcatca gtcggagggc
    12181 acggtcgtcg tcgcgtagct cgacgggccc ctggcactgc cacatcttcc gccaggaggt
    12241 gagggcgtcc atccactggc cgctgtcctc cttggcaggg ggaaggctgt cggcggacag
    12301 gtaccagcgg gccggcgaca ggatggtctt gtcgtagcgc acgcgcggta agaacggtag
    12361 ccgctcggct tgcgggcccc agtcgaaccc ggtccaggcg gggccgaagg cccgggtcag
    12421 gtgggcgagg aagcgggcaa ggagcggcgg ctgcttctcc agcgccatcg cgtggaagac
    12481 ctgcgggtcg atgacccggc ggcgcgaacg gctcacgagg tacaggcggt tggcagtggc
    12541 ggtgacggcg aggtcgtcga cgtcgatgac ctcgaccttc tcaccggcgg ggcgatgttc
    12601 tcccagggag atcgcgcgag gcaggtaggc agggatacgc gcgacgttct cgatgtgggc
    12661 gtacaggccc gggaaggaga gctgggcagt gagcgcgcct tcaatagtgg gcgggacttg
    12721 gcggtacacc tcttcgaggc cggagccggt ggcgaccggg gtgaaccggg aggtgagcgt
    12781 ccctgcgctt cgtgccggtg tgaccgtgac cgtgaagtgg ccgtcttgca gggcctgcag
    12841 gtcgcgggcg tggacgcggg cgcacatctc gacggaggag ggtgctgcat cgctcaccgc
    12901 aggcgccccc gcgatccggt cgaccagctc ctcggtgagc acgatctcgc ggctgccggc
    12961 agtggctgcc tcccatgcca cggcgagcag gcgcccgtcc cgctcggaca ccaccggcct
    13021 cgcggcgagt ctccggctgc ccgggtaccc ggccgggtag ccgagcccgg ccaccgggtc
    13081 gatgacgtcc ttgaccggca cgagggtgcc ggtgccgtaa cgctcccaga acgcggcgtg
    13141 atagtcccgc cacacgcctt ggccggccgg ctgtcgcgtg aggcgcagca gcgcgtcggc
    13201 agcccgttcc atctgcccta cgacgctgcg ggggatccgc acgtcggcgt ccaggaccag
    13261 gtcggcggcg atcgggctgc gtgccgccgc cgagacgttg cggcagttcc tcacggctgc
    13321 ctcgcgcgcg atgtgctggt cgcgggcggg ggccgtgttg tgctcccgga aggcttcttg
    13381 cacggccagg agaccatcga ggatgccggc cgcggagggc acactgtccg cgtcgatggc
    13441 cttgagctcg ccggcgaggt ggcccagcgg atcggtctcg gtcatcgggg cccgcaggtt
    13501 cgtcaggagg aacttctgtg ccatgaggga ggcgatcagc gcccgcgcac gtgtgggatc
    13561 ggcttccggg aacaccctgt cgagctcggc gagcagcgtg gtgacgcgaa cagggcgagt
    13621 ggtgtgcttc tcgatgagtc gtacgacgcg gctgcgccgg acggaggcgc ccctcggacc
    13681 cccatgctgg acgtgcagtc ggtccccgcg gggcatggcc agggagttca gaatgacgct
    13741 caggcggtcc aggagctccg ggatggactc caggcgggta cagacgtcgt ccagccattc
    13801 ggtgtctgcc cggatgacgg cacggtgagc gtcgccccac cgcacgtgcg gctgcctgtc
    13861 gattccggcg gccgctaccc cagcgaagag gccgaagggc gtcgggcgcc cggtggcgcg
    13921 cagaacgtag gagacggtgg cgaggtaggc acgccgtatc tgcctggggt gcacggggcg
    13981 tccgctgacg atgtcgttca gccgcgcggc cagatcgccg ctcgcttgcc ggatcgcgtc
    14041 ggcgaacacc cgttggcggc agacgtctcg cagccaatcg cttaccgcgt ctgtgtcgtg
    14101 tgggtccggc catgacgagg ggagtgccgt cagcggtgcc gcggcggcgc gcagcagcgc
    14161 tgcccctgtg tgctggtaga ccctggtgtg cttgcccatc ggtgtctccg ccgttgtgtt
    14221 cggaaggggg tggggccggg ggagtgcccc cggccccacg tcagcggccg tacgtcacac
    14281 ggcgctggcg cacgaggacg cgcaggtgga cttgcagccg tcgccggtgc cgcaggcctg
    14341 cggcagctgc tcggcgtcga tctcggtgac gacctccacc tggacgtcga acgggtcctc
    14401 cgccggagcc gtggtggtct ccgcgatcgg cttggtcagg acagcagcag gagccatgcc
    14461 tacatccctt ctgggtgatg attgctgtcg gccggctggc cggtgtgcag cccttccccg
    14521 gccggcccgg gccccgtggg gaacgagtcg aatcgatggc cgaggagggg gacttgatgc
    14581 ccgtcgagtg ggctaccgcg ggtggccgag atacagagcc gtgagcaggc tcccggtcgt
    14641 caccgcgggc agaacgagga tctggaacgt gccgaagccg caccggcggg cgtaccagcg
    14701 ggggtgacgc agcacatgcc agaggcgggc caatgtggtc agtgaggcag ccgccggttt
    14761 ctccgggctc acgctgctcc ctgtgtgagt aagccgttcg cctccggcct gtatcgcgct
    14821 gcgggtcatt cggtgctgcc tccgcccggc gtgggctgtc gtgtggttga gagcggggtt
    14881 gcggcggggc gccgtcggca tgctcacggg gcggccttcg gctcgcgagg gctcagcagg
    14941 gtgagccaga cgtccttgcc gccactggga gtgcggaaca cgccgaactg gtccgcgatg
    15001 acgctgacga gctggagacc gcggccgtcc tcgtcctcat cgccggcgca acggcgttgc
    15061 ggcagcgatg ggtcgtcgtc gtgcacgcag agcgccaccc catcaggagt gcgggtgacg
    15121 gtgatgagag cgctgcgtcg cccatcgcgg tccggccgag cgtggtgcag gacattggcc
    15181 agcagctcgg agacgacaag agccccggtg tcgaccagct tctccatgcc ccacaggcgc
    15241 aagtgcgcgc tcactaggac ccgcgcgatc cgcaccgaca gcggcgtcac gtcgtagtcc
    15301 atctccagca tgcccgcagt agcgcgcgtc gttccgcgca cgccggttgc agcggtgggg
    15361 tgagcaagga gactggccat tccagatcca cttcgttctg ggcgaacctc acgcgagagg
    15421 cccgactgcg gtgtgtactg gtgcgtgatc ggtcagcaac cattgagtca gaccgaagcc
    15481 cgaacgtgca gatgcagaaa cggaaagctc gactttccgt ttcaggaccc agggaacccc
    15541 cgtcatgccg cgacccgaaa agcagctgac tcccgacgcc tcgccgcgag actggttcgg
    15601 ccacgaggtg cggtactgga ggaagaagcg tggccactcg gcgtcctcgt taggcccgtt
    15661 ggtgcaggcc agcccctccc tcatcgagaa ggtggagaag ggccgggcct cgtgccgccg
    15721 cgacctggcg gagcgtttgg acgaggtgtt gacgaccggc ggcgtgctca cccgcgcctg
    15781 ggggatggtg tccggcgaat cggaaaagcg ccgtcgtgaa acggaaaaga atgccggccc
    15841 ctcgatggag ggcaccgttc aggcacacca aggccgcatc ctgggcagag agacttcgtc
    15901 gccgctgggg agcactgagc ctgtggaccg tcgcgccttc ctggccaaca gcagtctggc
    15961 cgccatcgca tcgatagacc ttgccgcgct cgtcgcctcc accaccccgc acgagccacc
    16021 caccaaaatt cgccccaagg acatcacggc agtcctcagc gtggctgaag acatccaccg
    16081 ccgggacaac gctcacggcg gcggagggct cgttggcgtt ctcgccggcc gagccatgga
    16141 gtgggcagtc cgtctgctca ccgtcccctg ccccgagcag ctccgcgccc cgctctacac
    16201 cgctgtcgca cgcctgggcg tcgtggtcgg cgcatcccgt ttcgacgcct acgcacacga
    16261 cgacgcccgc atcgctttca agatctccgc agactgtgcc gaggaggcca acgactggca
    16321 cctgcgcgcc aaggtgttct ccttcctcgc ccgacaggcc gtctggatcg gcgacccgga
    16381 cacaggcctc acctacgcgg agaagggcct cgtccgagcc gaccggctca caccgaccat
    16441 ccaggccatg ctgcacacgg cccgcgctcg cgccttcgga aagatgggcg acatcggcgg
    16501 cgccacggcg gccgtcggcg ccgccgacga cgccttcgcg aggtccaacc cgcaggacga
    16561 tccaccctgg atggcgtact acaacgaagc ccagcacgat ggggacaccg cacacgcgtt
    16621 gtacgacctg gtcctgttga aggaccagaa ccccggacag gccagtcggc gcttcgagac
    16681 cgccatcgaa ggccacgacg acgcatacgc ccgctcgcgc gcaatctccg gtacgaagct
    16741 ggcgagcctt ctgatggcca aaggcgaccc gcaacaggcc acagccatcg gccaccaggc
    16801 cctcacggac gccggccacc tgacctcccg gcgggccgcg gatgacctga aggaactcaa
    16861 ccggttcgcc gcccggcacc gtcgcacccc cgaagtggcg tacctgcgcg aacgaatcgc
    16921 cgctacgttg caggcatgac gatctcggcc cacgcttcat ccgcggtcct ggccgcagcc
    16981 tgctccgcgg ccgggctcga tccttctgcc gccgagccga tccgcatcgc ggagaacgag
    17041 atatggcgtc tgccgggtca gcgcgccatc gtacgcatcg cgcgccccgg tcagtgggca
    17101 gcagctgtcc gagaggtgag cgtcgcacag tggctggccg acaacgacgt gccagccgtt
    17161 cgcgcgctgc cggtcgacca gccggtcgag gtcagcgggc gcccggtgac cttctgggag
    17221 gaactaccag cgcacacaaa cggcaccgtc cgcgacgtgg tgcagctcct caaaaggctt
    17281 catccgctac cggttcccga cttcccactg ggcgacctcg acccattcgt ccgtgtgtcg
    17341 gagaggatcg acgccgccac gtccctgacc gagtatgacc ggtcatggct ccggcaacgg
    17401 cgtgaggagc tgcaacgcca gtggatccgg cgtccctccg gacttcccga ctgcgtcgtg
    17461 cacggtgacg cgtgggtggg caacgtcgcc cggacggccc gcggtccgat cctgttggac
    17521 ttcgagcggg tgtccgtggg cccaccggag tgggacctgg tctccaccgc ggtgaagctc
    17581 accacgaccg gcgccgtgag cccccccgag tacgcagagt tctgcgcctt gtacggcgta
    17641 gatgtgacgg agcgggaggg gtacgaactg ctttccagtg cccgcgagtt gcgcatggcc
    17701 acctacgcgg cccagcacgc cgccacccgg ccggagtgga cgaaggaagc gcagtatcgc
    17761 gtggactgcc tccgtggtcg gcgtgggccg cgcccctgga agtggacggg gattatgtag
    17821 tgctacgcgg ctaccgtgga ggttgtcgcg gatctcggga gggctgacgt ggatcgacgt
    17881 aacttcctcg caggtgtgcc gttcgcagcc ctcgccggcg tgggcccgtc gcgcgactgg
    17941 ctgatgagca cccttgacca cagccgtgag ccgggccccc gcgtgcgtct tgaggacgtg
    18001 acagcggtga agaacatgtt cagcgagttt caaaggatgg acgtgctcca aggaggcggc
    18061 tccggtcgcc tgatcctcgc cgagtacatg aatcaccacg tctatccgct gcttcgtcgc
    18121 acctacagcg aagacgtccg acgtgccctc tgcgaagccg cggccgagca gacgtacctt
    18181 ctcgggtgga tggcctatga caatggcgag catggcgtag cccagaggta cttgatccag
    18241 tccctgcgtc tcgccgagga atccggaaac gccgctctgg gctcccatgt gttggccggc
    18301 atggcagatc aggccacgct gcacggggac ccgatcgaag ggcgtcgcct ggcccaggcc
    18361 gggcgcctcg ggctgtccca cgtggactca cctgcctgcc tggcggacct ctggtgcctg
    18421 gaagcacgag cgctcgcatc gctcaacgac aaggcagcgg cggttcgagc cgtggtcgag
    18481 tcggagcggg catacgacag ggccggatcg ggggaccagc cggagtgggc ggcgttcatc
    18541 gaccccgcgt acctgcatgg cgagcacgcc aacacgttcc gggaccttgg tgatgccaag
    18601 tccgcggaag agcatgcccg gaagtccatc ggccatgcca ggagccagag acgtgctcgg
    18661 cggggagcca tgtcccaggc agctctcgcg gtctctcacc tgcagcggaa ggacttggag
    18721 gccgcccacg cggctggcgt tcggactctg aacctcacca ggcaggtcaa gtcctcgcgt
    18781 gcagtggaag ccgtgtacga cattcagcgg cgaatgcggc ctttcggtgg ccaccggctg
    18841 gtggcggact tcaacgagcg agtgagggaa ctcaccgcag cggcgtagcc gcgaacgcgg
    18901 gagccccggg ccctcgggcc cggggctcac ccctgccggt gcgggccggt ggtcaccggc
    18961 cggcggtcac cgcttcgccg ccttgtccgg gtccgcgttc ttgtccgtgt ccgcttccgt
    19021 gtccgcgtcc gcttccgtgt ccgcgtccgc gtccgcgtcc gattccggct gcgacgcgga
    19081 cagggccccg gcctccgggc cgtacgccgt caggaagcgg tcgcggaagg tgtccatccg
    19141 ccagaccggg gcgtccgggc cgggcttcag gccctcgtcc cactcccagt cggagatccg
    19201 gtccagcacg gcctcgtccc gggcgacgat cgagatcggt acgtcccggc tggccccctc
    19261 accggcgacg gtcgggacgg gctggtggtc gccgaggacg acgagcacgg tgtcctcgtc
    19321 gccgtactcc tccaggtacg agaccaggct gtccatcgag tactcgacgg cgcgccggta
    19381 ctcggtgcgc acctgctcgg ggtccttcca gacctcctcc gggtccttcc cctcctcctt
    19441 catggcgtgg tagacggagc cgttgccgac ctcgtcccag ccgatcatcc gcgggatggg
    19501 cgcccacggg ttgtggctgg tggcgaggat gatccccgcc atcagcgggt cacggtcctt
    19561 cttggcgcgc tccagccgct cgaaggcgga cagggtgtac tggtcgggta ccggcgtcca
    19621 gctgaacttc ggcccctggt aaccgagttc cttggagtcg tagatggcgt cgaagtcgta
    19681 gaacttgccc tccggccagg cccgggtgac gcccggcatc atgccgaccg tccgccaggc
    19741 gccggagcgc tggaaggcgc cggtgagggt gaggcggtcg ctcgccgtca cggtgcggta
    19801 ccgccgctgg ttgtcgaccc agaggcccga ccagagggtg gagtgggcca gccagctgcc
    19861 ggcgccggtc gtgggggagc ggaggaagcc gctccgggag gagaacccgg ccttgtccag
    19921 ccggtcggtg tcctccgcga gggccgcgct catgagccgc gacatctccg ggttctcgtc
    19981 gatcgccacc cggccgtagc tctcgatgaa ggcgaagagg acgtccttgc cgcgcagggc
    20041 ggtcagcagc tcgtcgggcg gggtgtcgcc gaagtcgtcg acggcggcca cccgggcgaa
    20101 cttgcgttcg tcctcgatgc ccgcctcgac ccgcttcacc cggtccttga cgagcttcgc
    20161 cgcggcgctg gaggccaccg gcgtgctgcc gatctggagg ccgatcgcgg agcaggtgat
    20221 ccagacgatg gcgacgacga aggtggtccg ggtggccgtc gcgcggtgcc ggaccaggat
    20281 ctcgctcagc cggatcaccg ccagtgtcat cagcacgggc acggcggcgg ccagggtcac
    20341 cgcgccgatc acggccgcgg tcgcggcggt cccgccgacc gtggactcca ggaaggagtg
    20401 gccgtcctcg aagaggatcc agtcgagcac caggtcgaac ggccggctca gcaccgagta
    20461 gaagccgatg tcgacgaact tcaggacgag cagcagcccg aggcccgccc cggagagcgc
    20521 cgcgacccac cgccggggcc tgggcggcag gaagagcagg acggctgcgg cgacgaccgc
    20581 ctcaccgggg aggcgcgtga aggcgaaggg cgtgaaccgg ctgagcccgt tcggcatgac
    20641 gagcgcggtg aagacgagca ggacggccag ggccgtcgtc ccgtacgtca ggaccctcgc
    20701 cgcggcgggg tgtccggccc gccaccggcc gtgcgggccg cggcgccagg ggcgccgggg
    20761 ggttccggcg gggcggctgc cctcggaggc gccgcctgcg gggccgtccg gggtgcgggc
    20821 cggggcgggc tcgtccgcgg gattgacggt tccggggccg acggcggggt tttcggtccc
    20881 ggcgggccgc ccggccggag cggactcctc tgcggtggac tcctctgcgg cggacggctg
    20941 ttcggggccg tggtccgctt cgtcgcctgc gcgggcgcgg tcgcctgcgg gggcggtgtc
    21001 gcctccgggg cgctggtccc cggctccggt gccgcccggg tccgtaccgg cggctgccgg
    21061 ggcgtcatcc gcgccggggc cggcggcgtc ccgcccgtcc gtaccgccgg cggcggtgtc
    21121 cccgtggccc gtcgcggtgc cccggtccgt gtccgtggcg gcggcccggt ccgggtccgc
    21181 ggtcgtggtg tcgtccggtg tgcgctcccg ggagtcgtcc ggcgccgggc cgtcctcctt
    21241 ggtggcgttg tccgttgtcg gaagctgacg agagagcggc aacccgaggg tccttccatg
    21301 cgaagcccgg tagtggcacg gcgggccggg cccgggagcg gggcccgccg ttaggggtac
    21361 ggccggtcgg cggtaaccac tcaatcaacc gggcgggcca cgcgagggaa actgccggtc
    21421 gtgacggcac ggtggccgtc cgcacccccc gggccggccg cctgctgtcc cggcggtcgc
    21481 cgggcccggg gagccctccg cgcttccgtg cccggccctc ccgccccggt tgccgccggc
    21541 gcggcgccgg gtgagcctgg acggaagggc gcggtggcgc gccggcgccc ggccgtgtgc
    21601 gggacgtcgc ggagaggtgg tggcgtggac cggacggagg ctcgcggacg gccgcgcgcc
    21661 agcggccacc ggaccgtgcc gcacaccgcc gacctgcggg tggaggcgtg ggcggagacg
    21721 gccgagcggt gcatcgccga ggcggtgcgt gccgccgtcg agagcttcgc ggacgtctcc
    21781 ggggccgtgg cggtggccga gcgcacgttc gaggtcacgg cggcgaccga cgaggacctg
    21841 ctggtctccg tcctcgatga ggccgtctac cgcctggacg ccgacggcga gatccccctg
    21901 gagaccgtgg tgggcccgat ccggggcggg gagggcggcc gggccgccac cgtccgctgc
    21961 cggatggccg acgcctcccg cactccgctg gtcggtgccg tgcccaaggc cgtctcgctg
    22021 catgacctcc ggctgcgcgg tgactccggg gaatgggcct gtgcggtgac cctcgacgtc
    22081 tgagacccgc ccggagccgg gcccggaccc gcccggaccc gggacggccg cggtggcggg
    22141 agaagggggc cggccgaatg gcggcgcggc cccggcggac cggaggtgga gatgtggaga
    22201 tcgtactgac ggaggagacc ccgtaccgct tccggatcga ggagcgggag gcgatgcgcg
    22261 tgccgggggt ggtcttcgcc tcgcgcgagc tgctgccgca ggcggccggg gacaaggccc
    22321 tggagcaggt cgcgaacgtg gcgaccctgc ccggcgtcgt ccgcgcctcg tacgcgatgc
    22381 ccgatgtgca ctggggatac ggcttcccga tcggcggggt cgccgccacc gacatcgatg
    22441 agggcggtgt cgtctcgccc ggcggcgtcg gcttcgacat ctcctgcggg gtgcggctgc
    22501 tggccgccgg gacgacccgt gcggaactgg accccggtgg tttcgagcgg ctgatggaca
    22561 tcctcggccg caccgtcccg cgtggcatgg gacgcggcgg cctgtgggag ctgcccggcc
    22621 cggacgcgat ggacgacctg ctggtggacg gcgcccggta cgccgtcgag cacggccacg
    22681 gggtgccccg cgatctggaa cgctgcgagg actccggggc gctggagggc gccgcgcccg
    22741 gcgaggtcag ccggcgggcg gtggagcggg gactggggca ggtgggcagt ctggggtccg
    22801 gcaaccactt cctggaggtc caggcggtcg gccacctcta cgatccggag gcggcggcgg
    22861 tcttcgggct gcggccggac caggtctgcg tcatgatcca ctgcggctcg cgcggactgg
    22921 gccatcaggt gtgcaccgac catgtgaagg tgatggaccg ggcgctgcac cgctacggca
    22981 tccgcctgcc ggaccgtcag ctcgcctgcg ccccggtcga ctcggccccg ggccgcaact
    23041 atctgggcgc catggcggcc gccgccaact acgggcgcgc caaccggcag ttgctctccg
    23101 aggcggcccg ccgggccttc accaccgcac tcgggaccgg tctcgacctg gtgtacgaca
    23161 tctcgcacaa catggccaag gtcgagacgc acgaggtgga cggccggcca cgccggctct
    23221 gcgtccaccg caagggcgcg accagggccc tgccgccggg tgacccggac ctgccggagg
    23281 acctcgcgga ggcgggacag ccggtgctcg tccccggcac catgggcacc gcctcgtacg
    23341 tcatgaccgg cctgcccggc aacgacgcct tccactccgc ctgccacggc gcgggccggg
    23401 tgatgagccg ccatcaggcg ctgcgcgcgg tccgcggcga gcggttgcgc gccgacctgg
    23461 agtcgaaggg cgtggccgtc cggccgtcct cctggcgggg gctggccgag gagaccccgg
    23521 aggcgtacaa ggacgtggac gtggtcgcgg acgtcacgga gggcgccggc ctcgcccggc
    23581 tcgtcgcccg tctggtgccg ctgggcgtcg tcaagggctg acggagcgtc ggcgcggcac
    23641 acgaagaccc cctgccaacg ggagcggcag ggggtctccg gcgcggtccg acgacggtgg
    23701 aggtgatcag ccgggggctt tcagggccgc cggccggagg acgtcggacc ggtgcgggtg
    23761 gagcgagtgg agcgggtgga gcgggacggg tgccgggcgc ggagtcgggg ccgggtccgg
    23821 cgtccgtccg tggtcaccgg cggccgtggc cccagtggcc gcggtggtgc ccgcgtccgt
    23881 ggccccagtg gccgcggtgg tgaccgcgtc cgcggtccca gtggccgtgg ccgtgaccgc
    23941 gtccgtggcc ccagcggccg tgtccgcggc cgtggccgtg accccggccc cggccgcggt
    24001 gctcggtgta cctctcctgg tcgtagctct gctcgtagcg gatctggccg cggtcggact
    24061 ggatgtccga ctgggccgcg gcggtgccgg tcccgaagat cccgaccgtc cccagcatgg
    24121 ccatgacgat ggcggccttc tgcagtttgc gcatgaggtc tcctcttcct ccagtgatgt
    24181 catccggcga accggatgg
//
