LOCUS       NZ_CP023202            11680 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1472101
            Orig. end                         :: 1483781
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11680
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11680
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11680
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6680](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6680
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    676..691
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     gene            761..1822
                     /gene="zapE"
                     /locus_tag="SXIN_RS06230"
     CDS             761..1822
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /gene="zapE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004923574.1"
                     /locus_tag="SXIN_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cell division protein ZapE"
                     /protein_id="WP_019706280.1"
                     /transl_table=11
                     /translation="MTDVTETPLSLCAREPQVPAERLVAEMVPPPRFRDARFETYLPDP
                     AQPSQAEAVEVLSGFAAGLGAGTAAGGGKRRWFTRKPAAPAGPRGVYLDGGYGVGKTHL
                     LASLWHATPAPPELKAFGTFVELTHLVGALGFQQTVRTLGDHRLLCIDEFELDDPGDTV
                     LVSTLLGKLVDAGVGLAATSNTLPGKLGEGRFAAQDFLREIQGLSAHFRPLRIDGEDYR
                     HRGLPEAPPPFAGEVVERAAHRTPGASLDAFPALLEHLSRIHPSRYGALTDGLRAVCLT
                     GVRPVPDQSTALRLVVLADRLYDREIPVLASGVPFDQLFGEDMLKGGYRKKYFRAISRL
                     TALARDAGPLAEA"
     gene            complement(1992..2666)
                     /locus_tag="SXIN_RS06235"
     CDS             complement(1992..2666)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471041.1"
                     /locus_tag="SXIN_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AIM24 family protein"
                     /protein_id="WP_019706226.1"
                     /transl_table=11
                     /translation="MRSDLFASENMVQPPTAPGMVLQNPKAVKYVVNGECYARQGSMIA
                     FRGNLRFEKQGQGVGNFLKRAVTGEGLALMAVRGQGEAWFAHEAANCFIIDFVPGDTLT
                     VNGRNVLCFDAGLGYEIKVVKGAGMAGGGLFNSVFTGQGRLAVICEGDPIVIPVSPQAP
                     VFVDTDAVVGWSAHLASSLHRSQSVGSMIRGGSGEAVQLRLEGDGFVIVRPSEAKPVPA
                     SN"
     gene            2749..3525
                     /locus_tag="SXIN_RS06240"
     CDS             2749..3525
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128420.1"
                     /locus_tag="SXIN_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_095757948.1"
                     /transl_table=11
                     /translation="MTSADTHTDTDTGTGTGSEAGHSHPDTAAFRPGAADRDAAPQFVL
                     PLVARIEKAAPPSRTDALETAARAVLVLLSDERAADPDGAWYRAVRDWQDARIRKVVRR
                     ARGAEWRRAAALPGITVTGGSAEVRVYPPVPVDGWPKELAKLQVSGTELEDPAPPAAPP
                     PGRPVLWLSPELEMSAGKAMAQAGHGAQLAWLRLPPAERSAWRAAGFPLAVRTAEPARW
                     ADLTGSGLPVVRDAGFTEIAPGSCTVVAEHPALTGR"
     misc_feature    complement(3790..3805)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            3906..4733
                     /locus_tag="SXIN_RS06245"
     CDS             3906..4733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018533917.1"
                     /locus_tag="SXIN_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_192883554.1"
                     /transl_table=11
                     /translation="MRRINGTAAILVAIAATIGALIYPIWSYEDRSGTGLANLQSQTVS
                     TKWGPLSALDRDFLVKVRLAGLWELPAGRQAMERAPNQAIRDAGDHLVVGHADLDRRAR
                     DIAAKLGVELPNEPTDQQKGWLREMTDAQGEDYQRKFANILRTAHGKVFGLIGQVRHTT
                     RNELIRDLADAANITVLDHITMLENTGMVDFDTIAAEEAAAATEKPAPPPPPPSTSSVI
                     GSPVPVVTPPGATSLPSAVPETTAPADDPGQPTATPTADQPAPGAGAPAGSAP"
     gene            5001..6680
                     /locus_tag="SXIN_RS06250"
     CDS             5001..6680
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010353179.1"
                     /locus_tag="SXIN_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_095756714.1"
                     /sec_met_domain="DUF692 (E-value: 1.9e-92, bitscore: 307.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARLGTGIGWRPEIARHVEELPGLDWVEVVAENICPGHLPDSLLR
                     LRERGTTIVPHGVSLGLGGPEPPDPARLAALAERAGALGAPLVTEHIAFVRAGGPLTAS
                     PRLEAGHLLPVPRTRDALDVLCANVRIAQDALPVPLALENIAALISWPGEELTEGQFLA
                     ELVERTGVGLLIDVANLHTNAVNRGEDPSAVLDALPCHALAYVHVAGGVERDGVWHDSH
                     AHPVTGPVLDVLAELCARADPPGVLLERDDDFPGPDRLAAELDAIRAVVTAARAARTAR
                     TAPARRGALSPPEAGPGRGAGRNPGSGTDGDGGAPAVPAETVTAAAEAAGLAASVAAGA
                     AAADARQRPACGAPPAAPGEPAATGTGAIGTGAIGTGAATGTGATAAPPDRSSAPPATE
                     AARLRLAVAQTALLSSLVAGTPAPDGFDRVRLAVQSRALVRKRTGVIAKVAPELPEILG
                     PRFRAEFEDYARNRPLTGGHRQDALDFAAHVLSPAGPRLEPAVRRRLGRWWRERSRPAP
                     PLRHRVAVLLRGGARRLSGRTGARRAQASPATSSETAFRRPV"
     gene            complement(6629..7342)
                     /gene="hemQ"
                     /locus_tag="SXIN_RS06255"
     CDS             complement(6629..7342)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358855.1"
                     /locus_tag="SXIN_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_019706350.1"
                     /transl_table=11
                     /translation="MTAPDKTPNAGKKAKDLNEVIRYTLWSVFRLRDVLPEDRGGYAEE
                     VDELFAQLAAKDVVVRGTYDVSGLRADADLMIWWHSETADALQEAYNLFRRTKLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADEEPRQYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGFPDVRANTVPSFSLGDYEWLLAFEADELYRIVDLMRHLRGSEARMHVREEVPFY
                     TGRRKAVSELVAGLA"
     gene            complement(7348..8889)
                     /gene="hemG"
                     /locus_tag="SXIN_RS06260"
     CDS             complement(7348..8889)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950064.1"
                     /locus_tag="SXIN_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_095757949.1"
                     /transl_table=11
                     /translation="MSETHASAGHVVVVGGGVSGLAAAHRLLAGGARVTVLEGSPRVGG
                     KLLAGELAGVPVDFGAESMLARRPEAVDLARAAGLSGRLQPPATASATLWTRGALRPMP
                     KGHVMGVPGDAEALAASGVISAEGLARIAREPELPPAVIGEGEDVAVGAYLADRLGREV
                     VDRLVEPLLGGVYAGDAYRISLRAAVPQLYRLAREGRSLTEGVRELQRRAAGQPDPGPV
                     FMGIDGGVGTLPPAVADACRAAGAEVATGASVTELRRTGAGWRLVVEGPGAEKAAAAAG
                     RSGASGASGGPRPSTGGGGTGPGRAVIEADGVVLAVPAPVAGRLLAAEAPAAAAALAAV
                     EYASMALVSMVFRRADLTPVPEGSGFLVPPVDGHTIKAATFASRKWGWIGAAAPDLFVI
                     RTSVGRFGEEAELKRDDEGLVEVSLRALGEAVGLRARPVATRVTRWTGGLPQYPVGHPD
                     RVARVREGLAGMPSLRLCGAAYDGVGIPACIASAHGAAGAVLDTLARSAGKDGGQ"
     gene            9152..10291
                     /locus_tag="SXIN_RS06265"
     CDS             9152..10291
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972881.1"
                     /locus_tag="SXIN_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_095756715.1"
                     /transl_table=11
                     /translation="MTDPIRPIPERPERPESPGSRAGGGRRGRSRRRRPARAAVAAAVL
                     LTALLGAAGCGSGGGADGKSAADAPAEQRDGGAGSAADGPAAGEAGAGDRAAQPGGTED
                     AAGPASPGDTRRTPASVPAHVIRTATLTVRVEDVPSALDTARTAAENAGGYVSDETTDR
                     DSDGRERSRLVLRVPQEKYTDVLEKLAGTGKLLERKVDAQDVTDQVVDVESRVKSQRAS
                     VARVRELMDRADKLSDIVTLEGELSTRQTELEALLAQRASLENRTAMATVTLRLTETER
                     AEKSGDELSFPDALAGGWHAFTTGLRWLAVAVGAVLPFVAALALILLLVRLAGRLLPDR
                     ATGRPRGPAESAESAEPAAEAASPAPGTGPAPSGRAAEE"
     misc_feature    11552..11572
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.28"
                     /tool="antismash"
ORIGIN
        1 ccgcaccgcc gtcgccggct cgacgccctc gccgggcccc gcggtgagca cctccgcgcc
       61 cgcgtcacgg gcacgccgga cccgttcggg gcgctccgcg acggcggcct cgccggtgag
      121 gacgagcgtg ggcacggccg gctccgtgaa cagcggcagg gagtagtcca ggtccaggct
      181 cgcgctcacc acggcgatca ccggggccgg cggctgtccc agggcggccc ggcgggccgc
      241 gaacgcctcg cgggcgcggg ccgggcggta cccctccttg cgcacggtct ccgctccggc
      301 gatcacaacg tccgccaggc cgcgcagcac tccgaagagg cgcatgtcgg ccgggcagga
      361 gagcggctgg gaccggccgt cgtggtacgc ggcgccgtcg agggaggcga ccatgttgcc
      421 ccgcagccag ggccgcgcgc cgtcctccgg ataggcgtag gcgtcggcca gttcgccgag
      481 gtcccactcg cgctcgacga gcaggtccgg ggccgcggac tcggcggtca gggggaacag
      541 acgtcgcatg gtcagcagtc tgtcacgcac cccggcggag cattccgggg cgcgcgaagc
      601 gcggccgccg gcgccggaag ccccgccccg gggccgcgcc ggaccggccc gccggacggc
      661 tgccccggcg gccggtgtgc gcgggatcac ggtccgcgac cggacggatg tccggatagg
      721 ctggggtgct gtgcactctt cctccgccgc cccgagcccg atgaccgacg tcacggagac
      781 tccgctgtcg ctctgcgccc gcgagccgca ggtgcccgcc gagcgtctgg tcgcggagat
      841 ggtgccgccg ccccgcttcc gggacgcccg cttcgagacc tacctcccgg acccggcgca
      901 gcccagccag gcggaggccg tcgaggtgct gagcggcttc gccgccggac tcggcgccgg
      961 caccgccgcg ggcggcggga agcgccgctg gttcacccgg aagccggccg cgccggcggg
     1021 cccgcgcggg gtgtatctcg acggcggcta cggcgtcggc aagacccacc tgctcgcctc
     1081 gctgtggcac gccacgcccg ccccgccgga gctgaaggcg ttcggcacct tcgtggagct
     1141 gacccatctg gtcggcgcgc tgggcttcca gcagaccgtg cggacgctcg gcgaccaccg
     1201 gctgctgtgc atcgacgagt tcgagctgga cgacccgggc gacaccgtgc tcgtgtccac
     1261 gctgctcggc aagctggtgg acgccggcgt cgggctcgcc gccacctcga acaccctgcc
     1321 gggcaagctc ggcgagggcc ggttcgccgc ccaggacttc ctccgcgaga tccagggcct
     1381 ctcggcgcac ttccggccgc tgcggatcga cggcgaggac taccgtcacc gcggcctgcc
     1441 cgaggcgccg ccgcccttcg cgggcgaagt ggtcgaacgg gccgcccacc gcaccccggg
     1501 cgcctcgctc gacgccttcc ccgctctgct ggagcacctc tcccggatcc accccagccg
     1561 ttacggcgcg ctcaccgacg ggctccgcgc cgtctgcctg accggggtgc ggccggtgcc
     1621 ggaccagtcc acggccctgc gcctggtcgt tctggcggac cggctgtacg accgcgagat
     1681 accggtgctg gcctcgggcg tgcccttcga ccagctgttc ggcgaggaca tgctcaaggg
     1741 cggctaccgc aagaagtact tccgggcgat ctcccggctc acggcgctcg cccgggacgc
     1801 cgggccgctg gcggaggcgt agaccggacc ccttccggcg gcagccggcg gcggcacggg
     1861 cccggccccg gaaccgccgc ggccgccccc gccgtccggg agttcccccg acctgacgcc
     1921 cgccccctcc gggccgcggc ccgcacgggc gtccggcctt acgcggcccg ctccctcccg
     1981 gccgccgcgc gtcagttcga cgcgggcacc ggcttcgcct cgctcggccg gacgatgacg
     2041 aacccgtcgc cctccagccg gagctgcacc gcctcgcccg agccgccgcg gatcatcgag
     2101 ccgacgctct gcgagcggtg cagggaggac gcgaggtgcg cgctccagcc gacgaccgcg
     2161 tcggtgtcca cgaagaccgg ggcctgcggt gagacgggga tgacgatcgg atcgccctcg
     2221 cagatcaccg cgagccggcc ctggccggtg aagacgctgt tgaacagccc gcccccggcc
     2281 atccccgcgc ccttgacgac cttgatctcg tagcccagtc cggcgtcgaa gcagaggacg
     2341 ttgcggccgt tgacggtgag ggtgtcgccg gggacgaagt cgatgatgaa gcagttggcc
     2401 gcctcgtggg cgaaccacgc ctcgccctgg ccgcggacgg ccatcagggc gagcccctcc
     2461 cctgtgacgg cgcgtttgag gaagttcccc acgccctgtc cctgcttctc gaaccggaga
     2521 ttgccgcgga aggcgatcat cgagccctgg cgggcgtagc actcgccgtt caccacatat
     2581 ttgaccgcct tggggttctg gagcaccatg cccggcgcgg tgggtggctg aaccatgttc
     2641 tcggaggcga agagatcgct gcgcatgggg caatgctgtc ccggaatgca tcattccgcc
     2701 aaggaggcgc ccgcgggcac gtaccgtgcg ggctggcaga ctggccggat gacctccgcc
     2761 gacacccaca ccgacaccga caccggcacc ggcaccggga gcgaggccgg ccacagccac
     2821 ccggacaccg ccgcgttccg gcccggggcc gcggaccgcg acgccgcgcc ccagttcgta
     2881 ctgcccctgg tggcccgcat cgagaaggcc gccccgccgt cccgcacgga cgcgctggag
     2941 accgcggccc gggcggtgct cgtgctgctg tcggacgagc gggcggcgga tccggacggc
     3001 gcgtggtacc gggccgtgcg cgactggcag gacgcccgga tccgcaaggt ggtgcgcagg
     3061 gcgcgcggcg cggagtggcg gcgcgcggcg gccctgccgg gcatcaccgt caccggcggc
     3121 tcggccgagg tgcgggtgta cccgccggtc ccggtcgacg gctggccgaa ggagctggcg
     3181 aagctccagg tgtccggcac ggagctggag gacccggcac cgccggccgc cccgccgccc
     3241 gggcggcccg tgctgtggct cagcccggag ctggagatgt cggcgggcaa ggcgatggca
     3301 caggcgggac acggcgccca gctggcctgg ctgcgcctgc cgcccgccga gcggtcggcg
     3361 tggcgcgcgg ccggtttccc gctcgccgta cggaccgcgg agcccgcgcg ctgggcggac
     3421 ctcacgggga gcggactgcc ggtggtgcgg gacgcgggct tcacggagat cgccccgggt
     3481 tcctgcacgg tcgtcgcgga acacccggcg ctcacggggc gctgagcgga gcccgcgcgc
     3541 cggagcgcac gcgggccgta cggatcccgg ggcggggtcc cggagccggt ggcacgccgg
     3601 ccgtcgcccg tgtccgggag cacctccggg cgggcgttgc ccggaccggg acaaccggag
     3661 cggcggggcc ccggtcgtga acatccggag cggatcgatc acgcctttga acacccgccg
     3721 cctcccgtac gtatcgatcc ccgacgccac cggaccgggc cccgcccggc cggcggcaga
     3781 ccaaccggct tgaccaaccg ctcagtccac gctggtccgg cacgccacgc cgctcctcac
     3841 gacggcacgg cgggccggcc ccgctcctcg ctccctgcga gtgcgccgcc atggcaggag
     3901 atactttgcg acgcatcaac ggaaccgccg ccatcctcgt ggcgatcgcc gcgaccatcg
     3961 gtgcgctgat ctatcccatc tggagttacg aggaccggtc cggcaccggt ctcgcgaacc
     4021 tccagtcaca gaccgtgtcc accaagtggg ggccgctgtc ggccctcgac cgggacttcc
     4081 tggtgaaggt gaggctcgcc ggtctgtggg agctgcccgc cggccggcag gccatggagc
     4141 gggcacccaa ccaggccatc cgcgacgccg gcgaccatct cgtcgtcggc cacgcggacc
     4201 tggaccggcg ggcccgggac atcgccgcca agctcggcgt ggagctgccg aacgaaccga
     4261 ccgaccagca aaagggctgg ctccgggaga tgaccgacgc ccagggcgag gactaccagc
     4321 ggaagttcgc caacatcctg cggacggccc acggcaaggt cttcgggctc atcggccagg
     4381 tgcggcacac cacccgcaac gagctgatcc gcgacctggc ggacgcggcc aacatcaccg
     4441 tgctcgacca catcaccatg ctggagaaca ccggcatggt cgacttcgac accatcgccg
     4501 ccgaggaggc cgcggccgcc acggagaagc cggctccccc gccgccgccc ccgtcgacct
     4561 cgtcggtcat cggctcgccg gtgccggtcg tcacgcctcc cggcgccacg tccctgccgt
     4621 ccgccgtgcc ggagaccacc gcgccggcgg acgacccggg gcagcccacc gcgacgccca
     4681 cggccgacca gcccgccccc ggcgccggcg caccggccgg ctccgccccg taacgggccg
     4741 acgggccacg acgggcaccg cggtccgccg gggcggccga ccgcggtgcc ggggcggagg
     4801 ggtggtccca ccccccacca gaccactcct ccgcccaccc ccggcctccc gcctcccgcg
     4861 ccccgccccg cggcggtagc tcaaatcaac ctctggaacc ggccctcgca cggttcggcg
     4921 gcccccgcgg aggccatgtc tcccggagag gaccggtaca cggagaaacc ggtacccgga
     4981 cgagggggga cggccggacc atggcacgac tggggacggg catcggctgg cggcccgaga
     5041 tcgcccgcca cgtcgaggag ttgccgggcc tggactgggt cgaggtggtg gcggagaaca
     5101 tctgccccgg ccatctcccc gactcgctgc tccggctgcg cgagcgcggt acgacgatcg
     5161 tcccgcacgg cgtctcactc ggcctcggcg gccccgaacc gcccgacccg gcccggctcg
     5221 ccgcactcgc cgaacgcgcc ggggccctgg gcgccccact cgtcacggag cacatcgcct
     5281 tcgtccgcgc gggcggcccg ctcaccgcct cgccccggct ggaggccggc cacctgctgc
     5341 cggtgccgcg cacccgggac gccctggacg tcctctgtgc gaacgtccgg atcgcgcagg
     5401 acgcgctgcc ggtgccactg gcgctggaga acatcgccgc gctgatctcc tggcccggcg
     5461 aggagctgac ggaggggcag ttcctcgccg aactggtgga gcgcacgggg gtggggctgc
     5521 tgatcgacgt cgccaatctg cacaccaacg ccgtgaaccg gggcgaggac ccgtccgcgg
     5581 tcctcgacgc cctgccgtgc cacgcgctgg cctacgtcca tgtggcgggc ggtgtcgaac
     5641 gggacggcgt ctggcacgac agccacgccc accccgtcac cggccccgtg ctggacgtcc
     5701 tggccgagct gtgcgcccgg gcggacccgc cgggcgtcct gctggaacgg gacgacgact
     5761 ttcccggccc ggaccggctg gcggccgaac tggacgccat ccgggccgtg gtgacggccg
     5821 cacgcgcggc ccgcaccgcc cgcaccgccc cggcgcgaag gggcgcgctc tccccgccgg
     5881 aggccggtcc gggcaggggc gcgggcagga acccgggcag cggcacggac ggggacgggg
     5941 gcgccccggc ggtgcccgcc gagaccgtca ccgcggcggc ggaggcggcc ggcctcgccg
     6001 cgtccgtggc ggccggcgcg gcggccgccg acgcacgcca acggccggcc tgcggagccc
     6061 cgccggccgc gcccggagag cccgccgcca ccggaacggg cgccatcggg acgggcgcca
     6121 tcgggacggg cgccgccacc ggaacgggcg ccaccgcggc tccaccggac cggagcagcg
     6181 ccccgccggc gacggaggcc gcgcggctgc ggctggcggt ggcgcagacg gcgctgctgt
     6241 cctccctggt cgccggtacc ccggcgcccg acggcttcga ccgggtccgg ctggccgtgc
     6301 agagccgggc gctggtccgg aagcggaccg gtgtgatcgc caaggtggcg cccgagctgc
     6361 cggagatcct gggcccccgg ttccgcgcgg agttcgagga ctacgcccgg aaccggccgc
     6421 tgaccggcgg ccaccgccag gacgcgctgg acttcgcggc gcacgtgctg agcccggccg
     6481 ggccccgcct ggaaccggcg gtgcggcggc ggctcggccg ctggtggcgc gagcgctccc
     6541 gcccggcccc gccgctgcgc caccgggtcg ccgtcctgct ccgcggcgga gcccgccggc
     6601 tgtccgggcg cacgggagcc cggcgggctc aggccagccc ggccaccagt tcggagaccg
     6661 ccttccgccg cccggtgtag aaggggacct cctcccggac gtgcatccgc gcctcggagc
     6721 cgcgcagatg acgcatgagg tcgacgatcc ggtacagctc gtcggcctcg aaggcgagga
     6781 gccactcgta gtcgccgagc gagaacgagg gcacggtgtt ggcccggacg tccgggaagc
     6841 cgcgcgccat cttgccgtgg tcggcgagca tcctgcggcg gtcctcgtcc ggcagcaggt
     6901 accagtcgta gctgcgcacg aaggggtaca cgctgacgta ctggcgcggc tcctcgtcgg
     6961 ccaggaacgc cgggatgtgc gacttgttga actcggcggg gcggtgcagc gccatgttcg
     7021 accacacggg ctccagcgca cggccgagct tcgtccggcg gaagaggttg tacgcctcct
     7081 ggagggcgtc ggccgtctcc gagtgccacc agatcatcag atcggcgtcg gcccgcaggc
     7141 cggacacgtc gtaggtgccg cgtacgacga cgtccttggc ggcgagctgc gcgaagagct
     7201 cgtccacctc ctccgcgtag ccgccgcggt cctccgggag cacgtcccgc agccggaaga
     7261 ccgaccagag ggtgtagcgg atgacctcgt tgaggtcctt ggccttcttg ccggcgttcg
     7321 gggtcttgtc aggagcagtc atggccctta ttgtcctccg tctttcccgg cgctccgcgc
     7381 cagggtgtcc agtacggcgc cggccgcgcc gtgcgcgctc gcaatgcagg ccgggatgcc
     7441 cacaccgtcg taggccgccc cgcagagccg cagcgacggc atccccgcca gcccctcgcg
     7501 gacgcgggcg acccggtccg gatggcccac cgggtactgc ggcaggccgc ccgtccagcg
     7561 ggtgacacgg gtggcgacgg ggcgggcgcg gagcccgacg gcctcgccca gggcccggag
     7621 cgacacctcg accaggccct cgtcgtcccg tttcagctcc gcctcctcgc cgaagcggcc
     7681 gaccgaggtg cggatcacga agaggtcggg ggcggctgcg ccgatccagc cccacttccg
     7741 gctggcgaag gtggccgcct tgatggtgtg tccgtccacg ggcggcacca ggaaaccgct
     7801 gccctcgggg accggcgtca ggtcggcgcg gcggaacacc atgctcacca gggccatgga
     7861 cgcgtactcg acggccgcca gcgcggcggc cgcggccggg gcctcggcgg cgagcagccg
     7921 cccggcgacg ggggcgggca cggccagcac cacgccgtcg gcctcgatca ccgcccgccc
     7981 ggggccggtc ccgccgcccc cggtggacgg ccgcggaccg ccggacgcgc cgctcgcgcc
     8041 ggaccggccc gccgcggccg ccgccttctc ggcacccggc ccctcgacga ccagccgcca
     8101 gccggcgccc gtgcgccgca gctccgtcac ggacgccccg gtcgcgacct ccgcgcccgc
     8161 cgcacggcag gcgtcggcga cggccggggg cagcgtgccg acgccgccgt cgatgcccat
     8221 gaagaccggc ccggggtccg gctgcccggc ggcgcgccgc tggagctccc gcaccccctc
     8281 ggtcagcgaa cggccctcgc gcgccagccg gtacagctgc ggtaccgccg cgcgcagcga
     8341 gatgcggtag gcgtcgccgg cgtagacgcc gccgagcagg ggttcgacca gccggtcgac
     8401 gacctcgcgg ccgagccggt ccgcgaggta tgcgccgacg gccacgtcct cgccctcgcc
     8461 gatgacggcg ggcggcagtt ccggctcccg cgcgatccgg gccaggccct ccgccgagat
     8521 caccccggag gccgccagcg cctccgcgtc acccggtacg cccatgacgt gccccttggg
     8581 catcgggcgc agcgcgcccc gcgtccagag cgtggccgag gcggtggcgg gcggctggag
     8641 ccggccggac aggcccgcgg cgcgggccag gtcgacggct tccgggcgcc gggcgagcat
     8701 cgactccgca ccgaagtcca cggggacgcc cgcgagttca ccggcgagca gctttccgcc
     8761 gacccgcggg gacccttcga gcaccgtcac ccgggcgccg cccgcgagca gccggtgcgc
     8821 ggccgccaga ccggagacac cgcctccgac gacaacgaca tggcctgcgg atgcgtgcgt
     8881 ctcactcatg ccgcccactc tctcagagcc cggcccgacc ggcgccaggg tccaatggcc
     8941 cctccggggg gttccggacc ggccgtgatc tccgccgggc cccgcccggc cgtccccttc
     9001 tcccccgcgt cccgcccggc cgcgcgccgc ttgccgccgg tatctccccg gtatcccacc
     9061 gtgaccgcat cggaaccgcg gaccggcaac ccggcccccg cccaccccgt cagaagggcg
     9121 acatcatcga acactcctgg ggggaccagc gatgacagac ccgatacggc ccataccgga
     9181 gcgcccggag cgcccggaga gcccgggaag ccgcgccgga ggcggccggc gcggcaggag
     9241 ccggcggcgc cggccggccc gcgccgcggt ggcggcggcc gttctgctca cggccctgct
     9301 cggcgccgcg ggctgcggca gcggtggcgg tgccgacggc aagtcggccg cggacgcccc
     9361 cgcggagcag cgggacgggg gcgccggcag cgcggcggac ggcccggccg ccggggaggc
     9421 cggagccggg gaccgcgccg cacagccggg cggtacggag gacgccgccg gcccggcctc
     9481 cccgggggac acgcgccgga cgcccgcgtc cgtgcccgcg cacgtcatcc gcacggcgac
     9541 cctcaccgtc cgcgtcgagg acgtgccgtc cgcgctcgac acggcccgta cggcggcgga
     9601 gaacgcgggc ggctacgtca gcgacgagac gacggaccgc gactccgacg gccgcgaacg
     9661 gtcgcgtctc gtgctgcggg tcccccagga gaagtacacg gacgtgctgg agaagctggc
     9721 cggcacgggc aagctcctcg aacggaaggt cgacgcgcag gacgtcaccg accaggtcgt
     9781 cgacgtcgag agccgcgtca agtcgcagcg cgcgagcgtc gcacgggtgc gcgagctgat
     9841 ggaccgggcg gacaaactca gcgacatcgt cacgctggag ggcgaactga gcacacggca
     9901 gacggagttg gaggctctgc tcgcccagcg ggcgtcgctg gagaaccgta cggcgatggc
     9961 caccgtcacg ctgaggctga ccgagacgga gcgggcggag aagtccgggg acgagctctc
    10021 cttccccgac gccctggcgg gcggctggca cgccttcacc acggggctgc ggtggctggc
    10081 ggtggcggtg ggcgccgtcc tgccgttcgt ggcggccctg gcgctgatcc tgctgctcgt
    10141 ccggctggcc gggcggctgc tcccggaccg cgccaccggc cggccgcgcg gcccggccga
    10201 gtcggcggag tccgctgagc cggcggccga ggccgcgtcg ccggcaccgg gcacgggacc
    10261 ggcgccctcg ggccgggccg cggaggagta gaccgccgcg ggggggcgcc gtgcacggcg
    10321 aactgcgggc cggccggcgc ccccgaatcc ccgcacgcgc gacgcgcgga gccggagccg
    10381 gggacccgcg ggcgggcgca tccatccccc gcccgccggg cagccgccct accgtggggg
    10441 cgaacagacg aagcccgggc gaaaggacac cgcatggcgg cgcggcggat gctcatcatc
    10501 ggcggagacg cggccggcat gtccgccgcg tcccaggcac gccggctgaa gggcccggac
    10561 gaactggaga tcctcgcctt cgagcggtcc gccttcacct cgtactccgc ctgcggcatc
    10621 ccgtactggg tcggcggcgt ggtcgacggc ccggaggccc tggtggcccg gaccgccgcc
    10681 gagcaccggg cccgcggcat cgacctccgg atgcacaccg aggtgaccgc ggtcgacacc
    10741 gcggcgcagc gggtgcgggt gcgcgaccgg gagggcggcg agcgctggga agggttcgac
    10801 gagctggtcg tcgccaccgg tgcccgcccc ctgcggccgg acatccccgg catcgacgcg
    10861 cccggcgtgc acggggtgca gaacctcgac gacggccggg cgctgcacga ggccctcggc
    10921 aaggacgccg aggggctgcg cgccgtggtc gtcggcgcgg gctacatcgg cgtggagatg
    10981 gccgaggccc tggtgaaccg gggctgccgg gtcaccgtgc tggagcaggc cgaacagccc
    11041 atgtcgacgc tcgacccgga catggggcgg atcgtccacg aggcgatgtg cgggctcggc
    11101 atccacaccg tgaccggcgc cgaggtgacg gaggtgctca ccggggacga cggccgggtc
    11161 gccggcgtcc gcacccggga ggagcagtac ccggccgatc tcgtggtcct gggcctcggc
    11221 gtccggcccg agacgcggct ggcccgggag gcggggctgc cgctcggcac gtccggcggg
    11281 ctcctgacgg acctcgcgat gcgggtgcgc ggcgaggaga acatctgggc gggcggggac
    11341 tgcgtggaag tcctcgatct ggtgtccggc cggacccggc acatcgccct cggcacccac
    11401 gccaacaagc acgggcaggt catcggcagc aacgtcggcg gcggctacgc caccttcccc
    11461 ggtgtggtcg gcacggcggt cagcaaggtc tgcgatctgg agatcgcccg gaccggactg
    11521 ctggaggcgc aggcccggca ggccgggctg gacttcgtca cggtgaccat cgagtcgacc
    11581 agccgggcgg gctattaccc cggcgcccgc cccatgacgg tgaagatgct cgccgagcgg
    11641 cgcacggggc ggctgctcgg cgtgcagatc gtcgggcgcg
//
