LOCUS       NZ_CP023202            22393 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1123301
            Orig. end                         :: 1145694
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22393
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22393
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22393
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12393](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12393
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(93..107)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    94..108
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     gene            248..2503
                     /locus_tag="SXIN_RS04815"
     CDS             248..2503
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019520959.1"
                     /locus_tag="SXIN_RS04815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 9 protein"
                     /protein_id="WP_238153929.1"
                     /transl_table=11
                     /translation="MLGTALSGPAIGAEPGPELVTNGDFSNGTTGWWFTANLPGAVVDG
                     RLCAEVPAGTANPWDAIVGQNDIPLTAGESYTLRYTATSTVPVTIRTNVQMATDPYTAE
                     LNASDQIDETAEPVEHIFTANADNEEAQLAFQIGGSDEAYTFCVDDVSLTGGAEPPVYE
                     PETGSPVRVNQVGYLTHAAKSGTVVTDATDPLDWTVQDAGGKQVAAGKTKPAGTDPTSR
                     QNVHTFDFSKVMTAGEGYTVTIGEDTSEPFAIGDDLYSSLRSDALAYFYHNRSGIEIEA
                     DLVGEEYARPAGHIGVEPNQGDTDVPCQEGVCDYSLDVSGGWYDAGDHGKYVVNGGISA
                     AQVMSNFERTLHTEGADGAPLGDGKLRVPERGNGVPDILDEARWQMDFLMKMQVPEGEE
                     LAGMAHHKIHDAQWTGLPLLPSEDPQPRELHPPTTAATLNLAATGAQCARLFEPYDQEF
                     AAECLEAAETAWAAAKANPDVLADPNDGTGGGAYSDDNVSDEFYWAAAELFVTTGEDTY
                     RQAVFGSELHGDTEALFPRGGLSWGWTGGLGSLTMATVPSDLTAGQLADVRATVAEAAD
                     GYAEASRKSAYGVPYDPEGNQYVWGSNSQVLNNMIVLATAHELTGKAGYRDAVLHGMEY
                     LLGRNPLNQSYVTGYGERDSHNQHHRFWANQLDPSLPNPAPGSVAGGPNTGIEDPVAQD
                     KLVGCAPAMCYIDDIESWATNEITINWNAPLAWVASYLDDQGSGTVKYKEKKKHRKH"
     misc_feature    complement(2736..2751)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     misc_feature    complement(2796..2810)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.98"
                     /tool="antismash"
     misc_feature    2797..2811
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.67"
                     /tool="antismash"
     misc_feature    complement(2806..2820)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.85"
                     /tool="antismash"
     gene            2845..4032
                     /locus_tag="SXIN_RS04820"
     CDS             2845..4032
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004984539.1"
                     /locus_tag="SXIN_RS04820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endo-1,4-beta-xylanase"
                     /protein_id="WP_019710824.1"
                     /transl_table=11
                     /translation="MRPIRFATAALATAALSLPLAATSAAADAPSGHPAASHSKAKAKN
                     ERLRSAAPDGFYVGTAVAGGGHHLEQDYPDPFTSDREYRKILGQQFNSVSAENQMKWEF
                     IHPERDRYDFGAADAIADFADRHKQVVRGHTLLWHSQNPEWLEQGDFSKEELRSILKEH
                     ITTVVGRYAGRIQQWDVANEIFDEQGNLRTEENIWIRELGPEIIADAFRWAHEADPEAK
                     LFFNDYGVEDDNAKSDAYYALTQELLAEGVPVHGFSAQAHLSTRYGFPGGLEENLRRFD
                     ELGLETAITELDVRMDLPESGVPTEAQLEQQADYYQRTLSACLAVEDCNSFTIWGFTDK
                     YSWVPVFFEGEGSATVMTEDFARKPAFHALYNTLLDAKKKDCKKHWKGWKKDWRR"
     gene            complement(4341..4874)
                     /locus_tag="SXIN_RS04825"
     CDS             complement(4341..4874)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379994.1"
                     /locus_tag="SXIN_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_039823205.1"
                     /transl_table=11
                     /translation="MQWKIHGERLLYENEWVNLWLTDIETPDGNRWEHHVVKLRHLAVA
                     AVVNERREILMMWRHRFITNAWAWELPMGLVEEGETPADAAAREVLEETGWRPGRVTPL
                     IYAEPANGITDSQHYVFRADGATYEGPPTEKNESDRIEWIPLADVRGMIDRREIVSSGS
                     LVGLLYVLMDEAIR"
     gene            complement(4823..6478)
                     /locus_tag="SXIN_RS04830"
     CDS             complement(4823..6478)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009305657.1"
                     /locus_tag="SXIN_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="membrane-associated oxidoreductase"
                     /protein_id="WP_238153675.1"
                     /transl_table=11
                     /translation="MSETNDLTPAEARIWRAFPRGEPVDFRAAGEEDPALGGTWGAERI
                     VRASVLRTLLVKAPQEEGQIAALKIAGVRITGVLDLKYAVVEAPIRLSHCRFDDVPDLY
                     GARLRQLNLSNSVLPGLTSATVRVDGVLRMTDCRVRGPVRLGGAQISGALFMERAEFTA
                     PDDSEPVLQLNQAAIGDDVWAPEMRAHGQVRLTGASVTGRTNIQDAEFDNPGGTALDAQ
                     NLTVAAHVRARRLRTRGRIDLRGSRISDRLDLVQAHLSHPGDTALRASSCVFGELWLHG
                     GGRIEGALNLRRSRIEILALEPEMLPDQVFLSNLTYTVLAPHEPAERRLPMLERDGDRY
                     EPYVYEQLTAAYRHVGDDDAARLVQLAKQRRRRATLTWYGRLWGYVQDAAVGYGFRPLR
                     AAVWLLSLMTIGSIAYGLDHPRPVKADEAPDFNVVFYTLDLLLPVISFGQEAAFAPEGG
                     HQWLSYALIITGWILATAIVAGPAGHETAAHETLAEALRSSVKTTEPSTVSVTKIGNPI
                     PRSVCSATLEANREGPRRCSGRSTGNVCSTRTSG"
     misc_feature    complement(6482..6497)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(6646..8109)
                     /locus_tag="SXIN_RS04835"
     CDS             complement(6646..8109)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064280.1"
                     /locus_tag="SXIN_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_019710827.1"
                     /transl_table=11
                     /translation="MNHKAAGTAEPAYVPDPNRWKALAVCLLSGFITLLDISIVNVGLP
                     SIREGLDAPESDIQWVLSGYALALGLLLVPAGRIGDARGRRRMFMIGMSLFTVASALCG
                     AAQSSTWLVLARFLQGLAGGILTPQVSALIQQMFRGAERGRAFGYFGTVIGLSTAVGPV
                     LGGVIIQIFGPEQGWRWIFYVNLPVCLLALVLARFLLPGPENATKPCARDLDPVGILLL
                     GAGVALLLLPLVEAQQWRGAGKWLLIPAALVFLAVFVRWELRQARHAQPLVDMGLFGLR
                     SYALGSLIMLFYFAGFTSIFFVFTLYLQSGLGYSALQAGLSITPFALGSALAAAFSGRF
                     VHRYGRALVVAGLLAVAAGLGGVMLAVYQVPGHQAGLAMALPLLLAGLGGGSVISPNQT
                     LTLAEVPPAQGGSAGGVLQTGQRIGSATGIAVAGSVFFASLGAGGNGDGDWAAAFRHSL
                     GVSVALVTLALAVAVLDLRARRAAAWPGS"
     misc_feature    complement(8306..8320)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.67"
                     /tool="antismash"
     misc_feature    8307..8321
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     gene            8607..10004
                     /locus_tag="SXIN_RS04840"
     CDS             8607..10004
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="SXIN_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_019710828.1"
                     /sec_met_domain="p450 (E-value: 4.4e-92, bitscore: 307.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDLSPDSGARDAGPPVPVPAVGLAERLRGGVSFRRDQLGFLQW
                     AARTHGDIVRFRLFGIPMIMLNHPDHIYRVLVEQRTKYDKDALLYRLVRPVLRDGLIGN
                     PGGELWQRQRRLMQPSFRPVIVARFAENMTDETTAMLERWERQYAPGAVVNVHEEFGEL
                     ALRIVNRSLFSARVGRAARDFAEAFTEANALLGRFFKFPFPPLTVPTPAHRRLRRAIDR
                     MDAFVASFVQRRTAEPGDEVDLLTLLMNAVDEDGDGRGMEPEQLHHEVLNLVVGAYETT
                     TNALSWIFYLLAAHPEVERKLHEEADAVLGGRVPRFEDMARTPYARSVVEETLRLYSPA
                     WQFMRRARTEDRIGGFHIPARSNIYLNSYVLHRHPQLWDDPESFDPGRFSPERSAGRPR
                     HAYMPFGGGERICIGQHFALTELHLVLLTLVRRHRFRLPPGQPPVRPQPLITLHPEGGV
                     PLEVHPR"
     misc_feature    9606..9608
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11158
                     /locus_tag="SXIN_RS04845"
     CDS             10001..11158
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970379.1"
                     /locus_tag="SXIN_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene cyclase"
                     /protein_id="WP_272951793.1"
                     /sec_met_domain="T1TS (E-value: 1.6e-85, bitscore: 286.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSPQQETRAGTGAEASAEAGVDAVHGPEDGSGPGSESGSASRP
                     GAAQPPEIHCPFPSEMSPHAEHAEAHLDAWVARFEVVRGTVARERFGRAGFAQFAARTY
                     PTADRACLDLVADWFGWLFLVDDQLDDGRVGRDIDSARRAMDGLLRVLDREGPAEGERP
                     PGEPPLAWALRDLWHRTASRATPAWRRRFTGHLAACLEAACWEAENRIAGVVPGEAEYI
                     EQRRHTGAIYVCMDLIDIVGDLDLPEAVHAGEPFQAVLRASSDVVVWTNDWYSLGKEMA
                     LGEYHNLVRVVAHARRLTLREALEHTAAAISAETRRYLGHRERLLAAHPEHRAALTTCL
                     AGMESWMRGNLDWSRATLRYRERERGGLPAYLEATLAPAGTEGGT"
     gene            11158..12393
                     /locus_tag="SXIN_RS04850"
     CDS             11158..12393
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="SXIN_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_095756630.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-56, bitscore:
                     190.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGRTGARTETRGTPPAEPGPGGTAPPPPPAPPVAVALAHEIVPP
                     ALLDWIARLGPDLATLCGYQMGLCDAEGAPGRPGPAAGPDRRTPEGTDASGRPGGGKLV
                     RPALALATAAAAGAEPKEALPAALAAELVHNFTLLHDDVMDGDRVRRHRPAAWVRFGTP
                     LAILAGDGLLALAFEVLSSHPAPGGAEVTGDLARALRQLCLGQGRDLLAAAVPPTAGSA
                     PPGSPGAAPGTEDTAAGTVPEISPEDCLRTLEAKTGALLGFACRAGAAYAGAPLAAQEA
                     FERFGSRLGLAFQLQDDVLGIWGRPGRTGKPALSDLRARKRSAPVVAALASGTAPGRRL
                     AKLYARPDPLGEDELALAADLVEAAGGRDWTLAEAERWREAGWESLRPLELSATGLAGL
                     RELTGRLTDRSS"
     misc_feature    11527..11529
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12415..12429
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            12591..14198
                     /locus_tag="SXIN_RS04855"
     CDS             12591..14198
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="SXIN_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_095756631.1"
                     /sec_met_domain="p450 (E-value: 1.5e-92, bitscore: 309.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPRPSPQSAPDPAAASGPQPSRAPGTAAADERGAPRAIPVARPV
                     KGPDGSRPRFSSDQIGFLERAAAEYGDIFRFRLFGMPVIVLNNPDHIHRVLVGNRHKYD
                     KEVLLYKLVRPVLRNGLITNPGGELYMRQRRMMQPAFRPAVVARFADGMTDETNSMLER
                     WRDRYRPGQVADLSAEFSELTLHIVTRTLFSAQVGETARRFAEAFTETNDILGRFFRFP
                     FPPLSVPTPAHRRLRRAIRRMDDCVSAFIERSSTPANAPDTTGPDAGAGKKPGHGIDLL
                     HLLMNAVDEEDGGGMDFEQLHHEVLNIVVGAYETTTNAMAWAFQVLAERPDVEARLHEE
                     IDTVLDGRPPGMDDLRRTPYARRVVEETLRMYSPAWQFMRRAREEDVLGGHRIPAGSNI
                     YINSYLLHRRPEYWEDPEVFDPDRFTPERSKDRNRHAYMPFGAGERICIGQHFALVELQ
                     LVLLAIAQRYRFTLPPGQPPVRPKPLTTLHPGGGVHLEVRPRSGGDGGTPPAHDGGDGG
                     GEAQDGRPGPAADPRSAS"
     gene            14195..16945
                     /locus_tag="SXIN_RS04860"
     CDS             14195..16945
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (507-839). E-value: 8.2e-49.
                     Score: 158.3. Matches aSDomain:
                     nrpspksdomains_SXIN_RS04860_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012428.4"
                     /locus_tag="SXIN_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_095756632.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.4e-48, bitscore:
                     162.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTERGSAPGPGSDTGSDTGTHSSTGTAAAPAAEGRRLGRRLRR
                     LCTVLGPMYVKFGQILSTRSDLLPPGAVAELRVLQDHGRAMSPRRVVRALEKEYGKPLG
                     QVFASFDPVPVASASIAQVHHATLRDGGTETRKTGSGAGTEEGDGTGTRVAVKVVKRGV
                     PASMRLHLALLRGLVRTAHALLPPIRTLRMPQRVAEIGRLLAEQLSMETERANMTAVAE
                     NFAGHPFVRVPRSHPELSTDRVLVMEYVEGIRGSEFAQVDVPPRELARRLQDILLTMLY
                     LDGTCHGDMHPGNILLTRDGRFTLIDFGITAYYTEAEKWGLVSFNNAAIHHRWDLAVRR
                     FTEYFVETDTRPKRRRSRGKKGTGAAAPAEALLADESYTTALKEVFVHHFETASDRWSG
                     TDFFRDVSEVLRRHGVSYTAAYTKGELAMLSCEGFMAQIDPELDIWENTRRFADRYSTS
                     LSGAVKERFDAYFAAATPKSLAMRDRARRSLVAPAHLDRYFFPSAYPLFIAGGSGARLT
                     DLDGNEYIDLAGGGGPAVLGRGHPVVQEALRSAAATCNINALGHEPEVALAELLTDAFP
                     GADRAVFSNSGTESALHAIRLCRVRRPGARRIAKFEGHFHGFSDQAMVSSWFRVAGPRD
                     APEAVAGCPGTPAGTVRDTLVLQFGHPRSLDVLRRNASDVAGVLVEPLPTTAGGIDRDY
                     LAALRALCTELDIPLVFDEVVSGFRVAYGGVQTLTGITPDLTVLGKIIGGGLPCGALVG
                     TAEMLEYGRTTGDPFRDAEERGFLGGTMSGNHLSCSTGLAALTHLRDNPDVYADLERRT
                     ELLADGMRAVAEEHGVPMRLRARHSVFSLAFTHKDLPYFRDSLHGVNFRATTALAYWMR
                     MYGVYLPELHAFLISAAHTDEDVASVLRSFDRSVGEMKAADLFVT"
     aSDomain        15716..16711
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SXIN_RS04860_Aminotran_3.1"
                     /evalue="8.20E-49"
                     /label="SXIN_RS04860_Aminotran_3.1"
                     /locus_tag="SXIN_RS04860"
                     /protein_end="839"
                     /protein_start="507"
                     /score="158.3"
                     /tool="antismash"
                     /translation="IAGGSGARLTDLDGNEYIDLAGGGGPAVLGRGHPVVQEALRSAAA
                     TCNINALGHEPEVALAELLTDAFPGADRAVFSNSGTESALHAIRLCRVRRPGARRIAKF
                     EGHFHGFSDQAMVSSWFRVAGPRDAPEAVAGCPGTPAGTVRDTLVLQFGHPRSLDVLRR
                     NASDVAGVLVEPLPTTAGGIDRDYLAALRALCTELDIPLVFDEVVSGFRVAYGGVQTLT
                     GITPDLTVLGKIIGGGLPCGALVGTAEMLEYGRTTGDPFRDAEERGFLGGTMSGNHLSC
                     STGLAALTHLRDNPDVYADLERRTELLADGMRAVAEEHGVPMRLRARHSVF"
     gene            complement(17051..17959)
                     /locus_tag="SXIN_RS04865"
     CDS             complement(17051..17959)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (35-233). E-value: 4.5e-42. Score:
                     135.6. Matches aSDomain: nrpspksdomains_SXIN_RS04865_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957335.1"
                     /locus_tag="SXIN_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_019710832.1"
                     /sec_met_domain="PCMT (E-value: 5.5e-05, bitscore: 21.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHEESPAGKAVPSSEDVGRLYDENTDVVDGAAGGNIHSGYWESED
                     DHSSLDEATDRLTDLVTGRLAVEPGQRLLDIGCGTGNPALRVAARHEAKVVGISVSQEE
                     IALARARAAESGLTGRVSFQYADAMALPAGTEPFAAESFDGAWAIESLMHMSDRAGALA
                     GAARTLRPGGRLVVADVLLRRPVHGETAEFVEQMCQAFQAPGLPGPEEYQDAVRRAGLE
                     LLEFTDIGENVRRTYRAFARILAEADGHGGHGGHGGDGGNGGEAAEDDGNEFLGSADAL
                     PRFGDLPEIGYVLLVARRPPA"
     aSDomain        complement(17261..17854)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SXIN_RS04865_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="4.50E-42"
                     /label="SXIN_RS04865_oMT.1"
                     /locus_tag="SXIN_RS04865"
                     /protein_end="233"
                     /protein_start="35"
                     /score="135.6"
                     /tool="antismash"
                     /translation="IHSGYWESEDDHSSLDEATDRLTDLVTGRLAVEPGQRLLDIGCGT
                     GNPALRVAARHEAKVVGISVSQEEIALARARAAESGLTGRVSFQYADAMALPAGTEPFA
                     AESFDGAWAIESLMHMSDRAGALAGAARTLRPGGRLVVADVLLRRPVHGETAEFVEQMC
                     QAFQAPGLPGPEEYQDAVRRAGLELLEFTDIGENV"
     misc_feature    complement(17705..17707)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18498..21584
                     /locus_tag="SXIN_RS04870"
     CDS             18498..21584
                     /GO_function="GO:2001070 - starch binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575950.1"
                     /locus_tag="SXIN_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate binding domain-containing protein"
                     /protein_id="WP_095756633.1"
                     /sec_met_domain="Alpha-amylase (E-value: 3.6e-34, bitscore:
                     117.3, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPTPHRPLARALAAVAAASVLPALLAATPATGNTPARAPSSATS
                     TATGATTTTKENTATVFYSTRTRNWQAYHLHYAPDGGSWTTAPGEPMEEACTDWVKKTV
                     DLGSASGLRAAFTDGSGTWDNNAGEDYDLGTGAITVKDGTVAHSDPCAGTDPDPAPGDD
                     SDGDGDDDGEAGGTAGTATVYYATSTVGWTTANLHYRPDGGAWTSVPGVGMEPACTGWM
                     RKSVDLGGATKLRAAFNNGNGVWDNNDGTDYTIPSGRSTVENGTVTGGAGDPCAAEAPD
                     TEAPSVPSGVTAEADGTSVVLTWEPSTDDRAVTRYQVTRTGGGRGTLVADTGSTVFSDT
                     DLEEQTAYSYTVRAVDAAGNVSAASSPAAVTTGAKPATPAAGKPLGTDPRKDPIYFVLT
                     ARFNDGDPANNRGGSQHEKSGNAAHDDPMFRGDFKGLVDKLDYIKGLGFSAVWITPVVL
                     NRSDYDYHGYHGWDFYRVDPRLESAGASYQDLIDAAHAKGMKIYQDVVYNHSSRWGAKG
                     LFTPTVYGVRDTDWSWYYDEPNDGFAYDGLTVEPKSGKSYYNGDLWSTAEPSGNTCLDW
                     GKPTGGTSPEGYRLYNCQWPNPTSGMFPKTYYHNCWIGNWEGEDSRSCWLHDDLADFNT
                     ENAQVQNYLIGAYDKYIDMGVDGFRVDTAVHIPRTTWNRRFLPAIQERVTAKHGAAAAR
                     NFFVFGEVAAFVNDKWNRGSVNHSAQFYTWKERKEYSADDAAAALEMYDWEQARGPSDQ
                     PMSQNAFLDGNTYRTPDHSRFSGMNVIDMRMHMNFGDARNAFHNGKDSDDSYNDATYNV
                     VYVDSHDYGPNKSSDRYAGGTDAWAENMSLMWTFRGIPTLYYGSEIEFRKGQKIDCGPS
                     CPLADTGRAYFGGHLAGEVKASGFGTVESASGEVADTLAQPLARHVQRLNLIRRAVPAL
                     QTGQYSTEGVSGDMAYKRRYTGGGTDSFALVTVTDGATFSGIPNGTYTDAVTGDTRQVT
                     DGELTVGAPGKGNLRVYVLDLGGTNAAPGKVGTDGPYLK"
     gene            21743..22246
                     /locus_tag="SXIN_RS04875"
     CDS             21743..22246
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SXIN_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019710834.1"
                     /transl_table=11
                     /translation="MYRTHGMCHGTGLRRAALTGAAVLTALALTAGTASALPAAPEDSR
                     SPRDAQGTGATQNPHGAEAPRNPQNARTAQGRTVSFRTHRAGAYFYHFREKLVVSDYKA
                     DGYGARAYLTWGSRRASVYAGGGRNSTDEKDLSIKEGTPVWLQLCTTKRGKNIRCTKTR
                     KGYA"
ORIGIN
        1 gccccgcaga ggccgcccca acgggcttgt cttgccgccg agttcggccg gccatacatc
       61 ttgacggcgc aacctcccgc ccccaagatg ccgtgggagc gctcccatac atctcctcgc
      121 ttcctgccca ccccacatcg cgcggaagga ccgagccgtg acacagcatc cgccccttga
      181 cccccctcag aggggccgcc cccaccgcgg caggcgccgc atcctcggcg ccgtcgccgt
      241 cgccggtctg ctgggcaccg ccctgtcggg gcccgccatc ggagccgagc cgggcccgga
      301 gctggtcacg aacggtgact tctccaacgg caccaccggc tggtggttca ccgccaatct
      361 cccgggcgcg gtcgtcgacg gccggctctg cgccgaggtc ccggccggca ccgccaaccc
      421 ctgggacgcc atcgtcggcc agaacgacat cccgctgacc gccggtgaga gctacaccct
      481 ccgctacacg gcgacctcca cggtgcccgt gaccatccgc accaatgtgc agatggcgac
      541 cgacccgtac accgccgagc tcaacgcctc cgaccagatc gacgagaccg cggagcccgt
      601 cgagcacatc ttcaccgcga acgccgacaa cgaggaggcc cagctcgcct tccagatcgg
      661 cggcagcgac gaggcgtaca ccttctgcgt cgacgacgtc tcgctgaccg gcggcgccga
      721 gccgcccgtc tacgagccgg agaccggcag cccggtgcgg gtcaaccagg tcggctatct
      781 cacccacgcg gcgaagagcg gcaccgtcgt cacggacgcc accgatcccc tcgactggac
      841 cgtccaggac gccggcggca agcaggtggc ggccgggaag accaagccgg ccggcaccga
      901 cccgacctcg cgccagaacg tccacacctt cgacttcagc aaggtgatga cggcgggcga
      961 gggctacacc gtcaccatcg gcgaggacac cagcgagccg ttcgccatcg gcgacgacct
     1021 ctactcctcg ctgcgctccg acgcgctggc gtacttctac cacaaccgca gcggcatcga
     1081 gatcgaggcg gacctggtcg gcgaggagta cgcgcgcccg gccggccaca tcggcgtcga
     1141 gcccaaccag ggcgacaccg acgtgccgtg ccaggagggc gtgtgcgact acagcctcga
     1201 cgtctccggc ggctggtacg acgccggtga ccacggcaag tacgtcgtca acggcggtat
     1261 ctccgccgcc caggtgatgt ccaacttcga gcgcaccctg cacaccgagg gcgcggacgg
     1321 cgcgccgctc ggcgacggca agctgcgggt gcccgagcgg ggcaacggcg ttccggacat
     1381 cctggacgag gcccgctggc agatggactt cctgatgaag atgcaggtgc ccgagggcga
     1441 ggagctcgcg ggcatggcgc accacaagat ccacgacgcg cagtggaccg gtctgccgct
     1501 gctgcccagc gaggacccgc agccgcgcga gctgcacccg ccgacgaccg ccgccacgct
     1561 caacctggcc gcgaccggcg cgcagtgcgc acgcctcttc gaaccgtacg accaggagtt
     1621 cgccgccgag tgcctggagg cggccgagac cgcctgggcc gcggcgaagg ccaacccgga
     1681 cgtgctcgcc gacccgaacg acggcaccgg cggcggcgcc tacagcgacg acaacgtctc
     1741 ggacgagttc tactgggcgg cggccgagct cttcgtcacc accggtgagg acacctaccg
     1801 ccaggccgtg ttcggctccg agctgcacgg cgacaccgag gcgctcttcc cgcgcggcgg
     1861 cctgtcctgg ggctggaccg gcggactcgg ctcgctgacc atggcgaccg tcccgagcga
     1921 cctgaccgcg ggccagctgg cggacgtccg cgccacggtg gccgaggcgg ccgacggcta
     1981 cgccgaggcc tcccgcaagt ccgcgtacgg cgtgccgtac gacccggagg gcaaccagta
     2041 cgtctggggc tccaacagcc aggtcctcaa caacatgatc gtgctggcca ccgcccacga
     2101 gctgacgggc aaggccgggt accgggacgc ggtgctgcac ggcatggagt acctgctggg
     2161 ccgcaacccg ctcaaccagt cctacgtcac cgggtacggc gagcgggact cccacaacca
     2221 gcaccaccgg ttctgggcca accagctcga cccctcgctg ccgaacccgg cccccggctc
     2281 cgtcgccggc ggcccgaaca ccggcatcga ggacccggtg gcccaggaca agctggtggg
     2341 ctgcgccccg gcgatgtgct acatcgacga catcgagtcc tgggcgacca acgagatcac
     2401 catcaactgg aacgcgcccc tggcgtgggt ggcctcgtac ctggacgacc agggcagcgg
     2461 caccgtcaag tacaaggaga agaagaagca ccgcaagcac tgatccggac ctgcccggtt
     2521 gagccgcggc gggcgctccg cggggagccg cccgccggcg gaccgggaca gcggtgagcg
     2581 atgcggcgcg gcggccgggg acaccaactg gtgttcccgg ccgcttagtt gcggaacgcc
     2641 gccgtccgcc ggagcacggc ccgaagggcg gggcgggccc gtccggccgt cgggccgcgg
     2701 aaggcgccga ccgaaccggc cgggcactcc tgcccgttca catctcttga ctccccgctc
     2761 ggcgagcctt taacgtccgg gagccacctt ccggaaactt tccggaaact tctgaaacgg
     2821 ttgacccgac acgggagtgc tccgatgaga cccatccgct tcgccaccgc cgcgctcgcc
     2881 acggccgccc tgtccctgcc gctggcggcg acgtcggccg ccgccgacgc gccctccggc
     2941 cacccggccg cgtcccactc caaggccaaa gccaagaacg agcgcctgcg ctcggccgct
     3001 cccgacggct tctacgtggg caccgccgtg gcgggcggcg gccaccacct cgagcaggac
     3061 tacccggacc ccttcacctc ggaccgggag taccggaaga ttctcggaca gcagttcaac
     3121 tcggtctccg ccgagaacca gatgaagtgg gagttcatcc accccgagcg cgaccgctac
     3181 gacttcggcg cggccgacgc catcgccgac ttcgcggacc gccacaagca ggtcgtgcgc
     3241 ggccacaccc tgctgtggca cagccagaac ccggagtggc tggagcaggg cgacttctcg
     3301 aaggaggagc tgcgctccat cctcaaggag cacatcacca ccgtcgtcgg ccgctacgcc
     3361 ggccggatcc agcagtggga cgtggccaac gagatcttcg acgagcaggg caacctgcgc
     3421 accgaggaga acatctggat ccgcgagctg gggccggaga tcatcgccga cgccttccgc
     3481 tgggcgcacg aggccgaccc cgaggccaag ctgttcttca acgactacgg cgtggaggac
     3541 gacaacgcca agagcgacgc ctactacgcg ctcacccagg agctgctcgc cgagggcgtg
     3601 cccgtgcacg gcttctccgc gcaggcccac ctgagcaccc gttacggctt cccgggcggc
     3661 ctggaggaga acctgcgccg cttcgacgag ctcggcctgg agaccgccat caccgagctg
     3721 gacgtccgca tggacctgcc ggagagcggt gtccccaccg aggcgcagct ggaacagcag
     3781 gccgactact accagcggac cctgtcggcc tgtctggccg tcgaggactg caactccttc
     3841 accatctggg gcttcaccga caagtactcc tgggtcccgg tgttcttcga gggcgagggc
     3901 tctgcgacgg tcatgacgga ggacttcgcc cgcaagccgg ccttccacgc cctctacaac
     3961 accctgctgg acgccaagaa gaaggactgc aagaagcact ggaagggctg gaagaaggac
     4021 tggcggcgct gagggaacgc ccctccgccc accacccgcc cgccgggtga cccgccgcga
     4081 tcacggtccg cggcgggtca ccggattcca cggaatccac cccggggccg tcctcgccgc
     4141 ctcgtccccg gcggcgacgg gcccgccgca cgcggagccc gcaccgggcg cccgcacggt
     4201 gcgacagggg cagcggcgcc gccccatacg ggccgtgccg ccgcgctctc cgtacccggg
     4261 gccacacagg gatgcctgct ccgggggcac cgcagagaac tagaaccggt ctctacccgg
     4321 gaacggcctg ccacgccaag tcagcggatc gcctcgtcca taaggacgta cagcagcccg
     4381 accagagaac cgctgctgac aatctcacgc cggtcgatca tgccccgcac gtccgccagc
     4441 gggatccact cgatccggtc ggactcgttc ttttcggtcg gcggaccttc gtacgtcgcc
     4501 ccatcggccc ggaagacgta gtgctgggag tcggtgatcc cattggcggg ctcggcgtag
     4561 atcagtgggg taacccggcc gggcctccag ccggtctcct caaggacctc acgggctgct
     4621 gcgtcggccg gcgtctcacc ctcttcgacc aggcccatcg gcaattccca ggcccaagcg
     4681 ttcgtgatga agcggtgccg ccacatcatg agaatttcgc gcctctcatt gacaacggca
     4741 gccacggcaa ggtggcggag cttgacgacg tggtgctccc agcggtttcc gtccggtgtc
     4801 tcgatgtcgg tgagccagag gttcacccac tcgttctcgt agagcagacg ttccccgtgg
     4861 atcttccact gcatcgccgc ggcccctctc gattggcctc cagcgtcgca gaacagacag
     4921 aacgaggtat cgggttcccg attttcgtca cactgacggt tgatggttca gtggtcttta
     4981 cggaagatcg gagggcctct gcaagggttt cgtgcgcagc ggtctcatgg ccggctgggc
     5041 ccgcgacgat cgccgtggcc aggatccagc cggtgatgat cagggcgtac gacagccact
     5101 gatgtccgcc ctcgggggcg aaggccgcct cttggccgaa gctgatgacc ggcaggagta
     5161 gatcgagagt gtaaaagacg acgttgaagt cgggggcctc gtccgccttg acggggcgtg
     5221 ggtggtccag gccatacgcg atcgagccga tggtcatgag ggacagcagc cagacggccg
     5281 cgcgcaacgg gcggaagccg tagccgacgg cggcatcctg cacgtatccc cacagccgtc
     5341 cgtaccaagt gagggtggcg cgccggcggc gctgcttcgc gagctggacg agccgggccg
     5401 cgtcgtcatc accgacgtgg cggtaggccg ccgtcaactg ctcgtagacg tacggctcat
     5461 agcggtcgcc gtcccgctcc agcatcggaa gacggcgctc ggcgggctcg tgcggggcga
     5521 gcacggtgta ggtgagattg ctgagaaaca cctggtccgg cagcatctct ggttcgaggg
     5581 ccaggatctc gatgcgggac cgcctgaggt tcagggcgcc ctcgatacga ccgccgccgt
     5641 gcagccagag ttcaccgaag acacaactgc tcgcccgcag tgccgtgtcg cccggatgcg
     5701 acaggtgcgc ttggaccagg tcgagacggt ccgatatgcg cgagccccgg agatcgatcc
     5761 ggccccgcgt gcgcaggcgc cgcgcccgta cgtgggctgc cacggtgagg ttctgcgcgt
     5821 cgagcgcggt gccgccgggg ttgtcgaact cggcgtcctg aatgttcgtc cgcccggtta
     5881 cggaggcgcc ggtaagccgc acctggccgt gggcgcgcat ctccggcgcc cacacgtcgt
     5941 ctccgatcgc ggcttggttg agttgcagca ccggctcgga gtcgtccggc gcggtgaact
     6001 ccgcccgctc catgaacagc gccccggaga tctgggcccc gccgagccgt accggccccc
     6061 gcacacgaca gtccgtcatc cgcagcactc cgtcgacccg cacggtcgcc gaggtcagac
     6121 ccggaagaac ggaattgctc agattgagct ggcgcagccg ggcaccgtag aggtcgggaa
     6181 cgtcgtcgaa cctgcagtgg ctcagccgga taggggcttc gaccaccgcg tacttgagat
     6241 ccaatacgcc ggtgatccgc acacccgcga tcttgagcgc ggcgatctgc ccctcctcct
     6301 gcggcgcctt gaccagaagc gtccgcagga cactcgcccg tacgatccgc tccgcgcccc
     6361 aggtaccgcc gagcgccgga tcctcttccc cggcggcgcg gaaatccacg ggctcgccgc
     6421 gcgggaaagc cctccatatg cgtgcctcgg ccggtgtcag atcgttggtc tcgctcacgc
     6481 cgggactctg gcgtgaccgc atgcgggccg tcaacttcct tacggcgcgg ccgtgctgcg
     6541 cgggttccac ctccagtgac agcggtggac gagccgcagg gccggaaagt gggcgacctg
     6601 cggtccggca tcgcgagaac cgccctcgac tcgcagaacg caccctcagg accccggcca
     6661 cgccgccgcc cggcgggccc gcaggtcgag caccgcgacc gccagtgcca gggtcaccag
     6721 cgccacggag acaccgaggc tgtggcggaa ggcggccgcc cagtccccgt ccccgttccc
     6781 tcccgcgccc aggctcgcga agaagacact tcccgcgacg gcgatgcccg tggccgaccc
     6841 gatccgctgg cccgtctgca gcaccccgcc ggcgcttccg ccctgcgcgg gcgggacctc
     6901 ggcgagcgtc agcgtctggt tgggcgagat gaccgagccg ccgcccagcc ccgcgaggag
     6961 cagcggcagc gccatggcca agcccgcctg gtggcccggc acctggtaca ccgccagcat
     7021 cacaccgccc agcccggccg ccaccgccag cagcccggcg acgaccagcg cccgcccgta
     7081 ccggtggacg aagcgcccgc tgaacgccgc cgcgagcgcc gatccgaggg cgaagggcgt
     7141 gatggacagc ccggcctgca gggcgctgta gcccagcccc gactggaggt agagcgtgaa
     7201 gacgaagaag atcgaggtga acccggcgaa gtagaacagc atgatgagcg accccagcgc
     7261 gtaggagcgc agcccgaaca gccccatgtc gaccagcggt tgggcgtgcc gcgcctgccg
     7321 cagctcccac cggacgaaga ccgcgaggaa caccagcgcg gccgggatca gcagccattt
     7381 gcccgcgccc cgccactgct gcgcctcgac cagggggagc agcagcagcg ccacgccggc
     7441 gccgaggagc aggatgccga ccgggtccag gtcgcgcgcg cagggcttgg tcgcgttctc
     7501 cggaccgggc agcaggaagc gcgccagcac cagggcgagc aggcagaccg gcaggttgac
     7561 gtagaagatc caccgccagc cctgctccgg cccgaagatc tggatgatga ccccgccgag
     7621 caccggaccg acagccgtgg agagcccgat gacggtgccg aagtagccga aggcgcggcc
     7681 gcgttcggcc ccgcggaaca tctgctggat gagcgccgag acctgcgggg tgaggatgcc
     7741 gcccgcgagc ccctgcagga accgggcgag caccagccag gtggaggact gcgccgcccc
     7801 gcacaaggcg ctggccacgg tgaacaggct catcccgatc atgaacatcc ggcgccggcc
     7861 ccgggcgtcc ccgatccgtc cggcgggcac cagcagcagg cccagcgcga gggcgtagcc
     7921 ggagagcacc cactggatgt cgctctcggg cgcatccagt ccctcgcgga tggagggcag
     7981 cccgacgttg acgatcgaga tgtcgagcag cgtgatgaac cccgagagca ggcagacggc
     8041 gagcgccttc cagcggttgg ggtcggggac gtacgcgggc tcggccgtgc cggcagcctt
     8101 gtggttcaca tgcggcctct cgtgtgatcg cctcgtccga ggatgacgca cccgggcggt
     8161 gccgtgcggt atccccggcg taccgcggac gtcgccggcc ccgggtgccc ccgggccccg
     8221 cctccgccgt gctcctcgtc cccggccgcg cacccgtccc cggcggtgcg ccggagctgc
     8281 cgccccgtca caccttccgg acggcctgag agcgctctcc cggtgtctcg gcggtgtgtc
     8341 cccaccgggc cgctccgcct gcccgcacgt ctgcctcttc gtcctctctt gggccggtcc
     8401 gctgtcatcg gcgtgcgcgg aagcggcagg gtgtggccca ttccgcggcg tgcttccgcg
     8461 gtgccgcgac ggccccgccg ggcgcccgcc ggcccggcgc accggcccac ctcgtacccc
     8521 tcgacccctc gacccatcga cccccaccac ctcacgctca ccgcacagtc ccgaagacgc
     8581 gcacagcacg tgaaggcgag gatcgtatga ccttggatct gtcaccggac agcggggccc
     8641 gggacgccgg tccccccgtc ccggtcccgg ccgtggggct cgcggagcgg ctgcggggag
     8701 gcgtcagctt ccgccgcgac cagctcggct tcctgcagtg ggcggcccgg acccacggcg
     8761 acatcgtgcg gttccgcctc ttcggcatcc ccatgatcat gctgaaccac ccggaccaca
     8821 tctaccgggt gctcgtcgaa cagcgcacga agtacgacaa ggacgcgctg ctctaccgcc
     8881 tggtccgccc ggtgctgcgg gacggtctga tcggcaaccc gggcggtgag ctgtggcagc
     8941 gccagcgccg gctgatgcag ccctcgttcc ggccggtgat cgtcgccagg ttcgccgaga
     9001 acatgaccga cgagacgacc gcgatgctgg agcgctggga gcggcagtac gcgccgggcg
     9061 cggtggtgaa cgtccacgag gagttcggcg agctggcgct gcggatcgtc aaccgttcgc
     9121 tgttcagcgc ccgggtcggc cgcgcggcgc gggacttcgc ggaggcgttc accgaggcga
     9181 acgcgctgct gggccgcttc ttcaagttcc ccttcccgcc gctgaccgtg cccaccccgg
     9241 cccaccggcg gctgcgccgg gccatcgacc ggatggacgc cttcgtcgcc tccttcgtcc
     9301 agcggcgcac ggccgagccg ggcgacgagg tggatctgct cacgctgctg atgaacgcgg
     9361 tggacgagga cggtgacggc cgggggatgg agccggagca gctccaccac gaggtgctga
     9421 atctggtcgt cggcgcctac gagaccacca ccaacgcgct ctcctggatc ttctatctgc
     9481 tcgccgcgca cccggaggtc gagcggaagc tgcacgagga ggcggacgcc gtgctcggcg
     9541 gccgggtgcc gcgcttcgag gacatggccc gcaccccgta cgcgcgttcg gtcgtggagg
     9601 agacgttacg gctgtactcg cccgcctggc agttcatgcg ccgggcgcgg acggaggacc
     9661 gcatcggcgg cttccacatc cccgcccggt cgaacatcta tctcaacagc tatgtgctgc
     9721 accggcatcc gcagctgtgg gacgacccgg agtccttcga ccccggccgg ttcagccccg
     9781 agcggtccgc cggccgtccc cggcacgcct acatgccgtt cggcggcggt gaacgcattt
     9841 gcatcggcca gcacttcgcc ctgacggagc tccacctggt gctgctcacc ctcgtccggc
     9901 ggcaccgttt ccggctgccg cccggacagc cgccggtgcg cccgcagccg ctgatcaccc
     9961 tgcatcccga gggtggcgtc cccctggagg tgcacccccg gtgaacggat ccccacagca
    10021 ggagacacgg gcggggacgg gcgcggaggc gagcgcggag gccggggtgg acgccgtcca
    10081 cgggccggag gacgggtccg ggcccgggtc cgagtccggg tccgcatccc ggcccggagc
    10141 ggctcagccc ccggagatcc actgcccgtt cccctcggag atgagcccgc acgcggagca
    10201 cgccgaggcc catctggacg cgtgggtggc ccggttcgag gtggtccggg gcaccgtggc
    10261 gcgcgaacgc ttcggccgtg ccgggttcgc gcagttcgcc gcccgcacgt acccgacggc
    10321 cgaccgggcc tgcctggatc tggtcgccga ctggttcggg tggctcttcc tcgtcgacga
    10381 ccagctggac gacgggcggg tcggccgcga catcgacagc gcccgccggg cgatggacgg
    10441 cctgctccgg gtcctggacc gggagggccc cgccgagggc gaacggccgc cgggcgagcc
    10501 gccgctggcg tgggcgctgc gcgatctgtg gcaccgcacc gcgagccgcg ccacccccgc
    10561 ctggcggcgc cgtttcaccg gccatctcgc ggcctgtctg gaggccgcct gctgggaggc
    10621 ggagaaccgc atcgcggggg tcgtgccggg cgaggccgag tacatcgagc agcggcgcca
    10681 caccggggcg atctacgtat gcatggacct catcgacatc gtcggggacc tcgacctccc
    10741 cgaggccgtc cacgccggtg agcccttcca ggcggtcctg cgggcctcca gtgacgtggt
    10801 cgtgtggacg aacgactggt actcgctggg caaggagatg gcgctgggcg agtaccacaa
    10861 cctggtacgg gtcgtggcgc atgcccggcg cctgaccctg cgggaggcgc tggagcacac
    10921 ggccgccgcc atctccgccg agacccggcg ctatctgggc caccgggaac ggctgctggc
    10981 ggcccacccg gagcaccggg ccgccctcac cacctgcctg gcgggcatgg agtcgtggat
    11041 gcgcggcaat ctggactggt cacgggcgac cctgcgctac cgggagcggg aacggggcgg
    11101 cctcccggcc tatctggagg cgaccctcgc gccggcgggc accgaaggag ggacgtgatg
    11161 accggccgga ccggcgcccg gacggagacc cgggggacac cgcccgcgga gccgggcccg
    11221 ggcgggaccg ctcccccgcc ccctccggcc ccgccggtgg ccgtcgccct cgcccatgag
    11281 atcgttccgc ccgccctcct ggactggatc gcccggctcg gcccggacct ggccacgctg
    11341 tgcgggtacc agatgggact gtgcgacgcg gagggcgcgc cgggccggcc cgggccggca
    11401 gcgggcccgg accgtcgtac tcccgagggc acggacgcct ccgggcgtcc ggggggcggc
    11461 aagctcgtgc gtcccgctct cgcgctggcc accgccgccg ctgccggggc ggagcccaaa
    11521 gaggcgttac cggccgcgct cgccgccgaa ctcgtccaca acttcacgct gttgcacgac
    11581 gacgtgatgg acggcgaccg cgtacggcgc caccggcccg ccgcctgggt gcgcttcggc
    11641 accccgctgg ccatcctcgc cggtgacggt ctgctggccc tcgccttcga ggtgctctcc
    11701 tcgcacccgg cgcccggcgg cgccgaagtg accggcgatc tcgcccgcgc cctgcggcag
    11761 ttgtgtctcg gccagggccg cgacctgctg gccgcggcgg tcccgcccac ggcgggaagc
    11821 gcgccgcccg gctcccccgg ggcggccccg gggacggagg acacggcggc cgggaccgtt
    11881 ccggagatca gccccgagga ctgcctgcgc acgctggagg ccaagacggg tgcgctgctg
    11941 ggcttcgcct gccgggcggg cgcggcctac gcgggcgcgc cgcttgccgc gcaggaggcg
    12001 ttcgagcggt tcgggtcccg gctcggactg gcgttccagc tccaggacga cgtcctcggc
    12061 atctgggggc gccccggccg caccggcaaa ccggctctct ccgatctgcg ggcgcgcaag
    12121 cggagcgcgc cggtggtcgc cgccctcgct tccggcacgg ctccgggccg ccggctggcg
    12181 aagctctacg cgcgcccgga tccgctcggc gaggacgaac tcgcgctcgc cgccgacctg
    12241 gtggaggcgg ccggaggccg cgactggacc ctggccgagg cggaacggtg gcgggaggcg
    12301 ggctgggaga gcctgcgccc gctggagctg tccgcgacgg gcctcgccgg tctgcgggaa
    12361 ctcaccggcc gcctcaccga ccgctcctcc tagcccgggc aggcgggccg ccccgggccc
    12421 tccgcccctc ccccaagcac cccgccctgg tgcccccgcc ccggccctgc cgccgactgc
    12481 gccgtcccct ccctccgggg cctgccgtca ccgccccgtc cagcccttct ccgccgttcc
    12541 caccaccccg caccccgccc cgcctcccac cgacagaaag ggtgagtggc ttgcccccac
    12601 gtccctcccc gcagtccgcc cccgaccccg ccgcggcctc cggcccgcaa ccgtcccggg
    12661 caccgggcac cgccgccgcg gacgaacggg gcgctccccg cgccataccc gtcgcccgcc
    12721 cggtgaaggg ccccgacggc agccgccccc gcttcagcag cgaccagatc ggcttcctgg
    12781 agcgggccgc ggcggagtac ggggacatct tccggttccg gctgttcggg atgcccgtca
    12841 tcgtcctgaa caaccccgac cacatccacc gggtactcgt cggcaaccgg cacaagtacg
    12901 acaaagaggt gctgctctac aagctggtcc gcccggtgct gcgcaacggg ctcatcacca
    12961 accccggcgg tgagctctac atgcgccagc gccgcatgat gcagcccgcg ttccgcccgg
    13021 ccgtggtggc ccggttcgcc gacggcatga cggacgagac gaacagcatg ctcgagcgct
    13081 ggcgggaccg gtaccgcccg ggtcaagtgg cggacctcag cgcggagttc agcgagctga
    13141 ccctgcacat cgtcacgcgc acgctgttca gcgcccaggt cggcgagacg gcacgccgct
    13201 tcgccgaggc cttcacggag accaacgaca tcctgggccg cttcttccgc ttcccgttcc
    13261 ccccgctctc cgtgccgacc ccggcgcacc ggcggctgcg ccgggcgatc cggcgcatgg
    13321 acgactgcgt gtccgcgttc atcgaacgca gcagcacccc cgcgaacgcc ccggacacca
    13381 ccggcccgga cgccggcgcc gggaagaagc ccggccacgg catcgatctg ctgcacctgc
    13441 tgatgaacgc cgtcgacgaa gaggacggcg gcggcatgga cttcgaacag ctgcaccacg
    13501 aggtgctcaa catcgtcgtc ggcgcctacg agacgaccac caacgccatg gcctgggcct
    13561 tccaggtcct cgcggagcgc ccggacgtcg aggcccggct gcacgaggag atcgacacgg
    13621 tgctggacgg acggccgccc ggcatggacg atctgcgccg caccccgtat gcccgcaggg
    13681 tcgtcgagga gacgctgcgc atgtactcgc ccgcctggca gttcatgcgg cgggcccgcg
    13741 aggaggacgt gctcggcggc caccgcatcc ccgccgggtc gaacatctac atcaacagct
    13801 acctcctgca ccgccgcccg gagtactggg aggacccgga ggtcttcgac ccggaccgct
    13861 tcacccccga gcggtcgaag gaccggaacc ggcacgcgta catgccgttc ggcgcggggg
    13921 aacgcatctg catcgggcag cacttcgcgc tggtggagct gcagctcgtg ctgctggcca
    13981 tcgcccagcg ctaccgcttc acgctgccgc cgggccagcc accggtacgg ccaaagccgc
    14041 tgaccactct gcaccccggc ggcggcgtcc atctggaggt ccggccgcgg tccggcggcg
    14101 acggcggcac tcccccggcg cacgacggcg gcgacggcgg cggcgaggca caggacggcc
    14161 ggcccggccc ggccgcggac ccgcggagcg cctcatgacc accaccgaaa ggggctccgc
    14221 ccccggcccg ggcagcgaca ccggcagcga caccggcacg cactcgtcca ccggcaccgc
    14281 cgcggcaccc gccgccgagg gccgccggct cggccgccgc ctccgccgcc tctgcaccgt
    14341 cctcggcccg atgtacgtga agttcgggca gatcctttcc acccgctccg acctcctccc
    14401 gcccggcgcc gtcgcggagt tgcgcgtcct gcaggaccac gggcgcgcga tgagcccgcg
    14461 gcgcgtcgta cgggccctgg agaaggagta cggcaaaccg ctcggccagg tcttcgcctc
    14521 cttcgacccc gtcccggtcg cgagcgcctc catcgcccag gtgcaccacg cgacgctcag
    14581 ggacggcggg acggagacgc ggaagaccgg aagcggggcc ggaaccgaag agggggacgg
    14641 taccgggacc cgcgtcgcgg tcaaggtggt caagcgcggc gtgcccgcct ccatgcggct
    14701 gcacctggcg ctgctccgcg gcctcgtccg gaccgcccac gccctgctgc cgccgatccg
    14761 cacgctgcgg atgccacagc gcgtcgccga gatcggccgg ctgctcgccg agcagctcag
    14821 catggagacc gaacgcgcca acatgacggc cgtcgccgag aacttcgcgg gccatccctt
    14881 cgtccgcgtc ccccgctccc acccggagct ctccaccgac cgggtgctgg tcatggagta
    14941 cgtggagggg atcaggggca gcgagttcgc ccaggtggac gtcccgccga gggagctcgc
    15001 ccgccggctc caggacatcc tgctgacgat gctgtacctc gacggcacct gccacgggga
    15061 catgcacccg ggcaacatcc tcctcacccg cgacggccgc ttcaccctga tcgacttcgg
    15121 catcaccgcc tactacaccg aggccgagaa gtgggggctg gtctccttca acaacgcggc
    15181 gatccaccac cgctgggatc tggcggtccg ccgcttcacg gagtacttcg tggagacgga
    15241 cacccgtccg aagcggagaa ggtcaagagg gaagaaaggg accggggcgg cggcccccgc
    15301 ggaggccctg ctggccgacg agtcctacac caccgccctc aaggaggtct tcgtccacca
    15361 cttcgagacg gcctccgacc gctggtcggg cacggacttc ttccgcgacg tcagcgaggt
    15421 gctgcgccgc cacggcgtct cgtacacggc cgcctacacc aagggcgagc tggcgatgct
    15481 ctcctgcgag ggcttcatgg cccagatcga cccggagctc gacatctggg agaacacgcg
    15541 ccgcttcgcc gaccgctact cgacctccct cagcggcgcg gtcaaggagc gcttcgacgc
    15601 gtacttcgcg gcggccacgc ccaagtcgct cgcgatgcgg gaccgcgccc ggcggtccct
    15661 ggtcgccccg gcccacctcg accgctactt cttccccagc gcctaccccc tgttcatcgc
    15721 cgggggcagc ggggcgcggc tgaccgacct cgacggcaac gagtacatcg acctggcggg
    15781 cggtggcggt cccgctgtcc tgggacgcgg ccaccccgtc gtgcaggagg cgctgcgctc
    15841 ggcggccgcc acctgcaaca tcaacgcgct gggccacgag cccgaggtgg ccctggccga
    15901 actcctgacc gacgccttcc cgggcgcgga ccgggcggtg ttctcgaact ccggtacgga
    15961 gtccgctctg cacgccatcc ggctgtgccg ggtgcgccgc ccgggggcgc gccggatcgc
    16021 caagttcgag gggcacttcc acggcttctc ggaccaggcg atggtgagct cctggttccg
    16081 ggtggcgggg ccgagggacg ccccggaggc ggtcgccggc tgcccgggca cacccgccgg
    16141 gacggtccgc gacaccctcg tcctccagtt cggccacccg cgcagcctgg acgtcctgcg
    16201 ccgcaacgcc tccgacgtgg ccggggtgct ggtcgaaccg ctgccgacga ccgcgggcgg
    16261 tatcgaccgg gactatctgg ccgcgctgcg cgcactctgc accgagctgg acatccccct
    16321 ggtgttcgac gaggtggtct ccggtttccg ggtagcgtac ggcggggtgc agacgctcac
    16381 cggcatcacc ccggacctca ccgtgctcgg gaagatcatc ggcggcgggc tgccgtgcgg
    16441 cgcgctggtg ggcacggcgg agatgctcga gtacggccgc acgaccggcg acccgttccg
    16501 cgacgccgag gaacgcggct tcctgggcgg cacgatgagc ggcaaccacc tgtcctgcag
    16561 tacgggcctc gccgccctga cccatctgcg ggacaacccg gacgtctacg cggacctgga
    16621 gcgccggacg gaactgctgg ccgacggcat gcgggcggtc gcggaggagc acggcgtgcc
    16681 gatgcgactg agggcccgcc actccgtctt ctccctcgcc ttcacccaca aggatctgcc
    16741 gtacttccgg gacagcctcc acggcgtcaa cttccgcgcc accacggccc tcgcgtactg
    16801 gatgcggatg tacggcgtct acctgccgga actgcacgcg ttcctgatct ccgctgccca
    16861 cacggacgag gacgtggcga gcgtcctgcg gagcttcgac cgctcggtcg gcgagatgaa
    16921 ggccgcggac ctgttcgtca cctgaggcgc cctctcaggc tccgccggct ccgccccctt
    16981 ctctcccgcc ccgggaagag aagggggcag acaccgcccg cccggccgcc gggcccgccg
    17041 ggagccgcgc tcaggcgggc ggccgccgcg cgacgagcag gacgtagccg atctccggca
    17101 ggtccccgaa ccggggcagg gcgtccgcgg agccgaggaa ctcgttcccg tcgtcctccg
    17161 cggcttcccc gccgttccct ccgtctccgc cgtgaccccc gtggcccccg tggccgtcgg
    17221 cttccgccag gatccgcgcg aaggcccggt aggtgcggcg gacgttctcc ccgatgtccg
    17281 tgaactccag cagttccagc ccggcccgcc gcacggcgtc ctggtactcc tccggcccgg
    17341 gcagcccggg tgcctggaac gcctggcaca tctgctcgac gaactccgcg gtctccccgt
    17401 ggaccggccg ccgcagcagc acgtcggcga ccaccagccg cccgccgggc cgcagcgtcc
    17461 gggcggcgcc ggcgagggca ccggcccggt cggacatgtg catcagggac tcgatcgccc
    17521 aggccccgtc gaaggactcc gccgcgaagg gttccgtccc ggccggcagc gccatggcgt
    17581 ccgcgtactg gaacgacacc cggccggtga gcccggactc cgccgcccgg gcccgggcga
    17641 gcgcgatctc ctcctggctc acggagatcc cgaccacctt cgcctcgtgg cgggcggcga
    17701 cgcgtaacgc ggggttgccc gtgccgcatc cgatgtcgag cagccgctgc cccggttcca
    17761 cggcgagccg gccggtgacc aggtcggtga gccggtccgt cgcctcgtcc agggagctgt
    17821 ggtcgtcctc gctctcccag tatccggagt ggatgttgcc gccggccgcg ccgtcgacga
    17881 cgtccgtgtt ctcgtcgtag agccggccga cgtcctcgga cgacggaacg gccttcccgg
    17941 ccgggctttc ctcgtgcatg cggaactcct catcgcggcg cgcggagcgc gcgggacgca
    18001 gtggactgga acggtcggcg gcgggccggc ggcaccgccg cgagtcctcc ggggagggcc
    18061 ctcaccggag ggcggtggcc cacggatgcg gaagatcctc caccagggcg caccaccggg
    18121 cccatgggcg catgggcagc atcgggtgcc gggggtgccg acccttctgc cctccgccga
    18181 ccgtcccgcc gtcccggccc gggctccccc catgccccgg cgccgaccgc cccggccgtc
    18241 ggcagcggtc caagtgccgc tcacggtacg actgttgacg ggactgtcat gtacgggcaa
    18301 tctcgatgca acagcttgca gcaagttcca tcactcacgc tgcgggccta cgagcagtgc
    18361 tcgccagaac ccggaggcgc gtcagggatt cccggcgaag ccgcgcggac gccgcacccc
    18421 ctcgggcgtc cgcgcccgtc agtcggtcaa ccgcggccac cccgggccgc ggcagccctc
    18481 cgccccctgg agcacgcatg aaacccaccc cgcaccggcc gctcgcgcgc gccctcgcgg
    18541 cagtcgcggc ggcctccgtg ctgcccgccc tgctcgccgc caccccggcg accgggaaca
    18601 ccccggcgcg cgcgccgtcc tcggccacct ccacggcaac cggcgccacc accaccacga
    18661 aggagaacac cgcgacggtc ttctactcca ccaggaccag gaactggcag gcgtaccacc
    18721 tccattacgc cccggacggc ggctcctgga cgaccgcccc gggtgagccg atggaggaag
    18781 cctgcacgga ctgggtgaag aagaccgtcg acctgggcag cgcctccggc ctccgggccg
    18841 ccttcaccga cggctccggc acctgggaca acaacgccgg cgaggactac gacctgggca
    18901 ccggcgccat cacggtcaag gacggcacgg tggcccacag cgacccgtgc gccggcacgg
    18961 acccggaccc ggctcccggc gacgacagcg acggcgacgg cgacgacgac ggggaagccg
    19021 gcggcacggc cggcaccgcc accgtctact acgccacctc caccgtcggc tggaccacgg
    19081 cgaacctcca ctaccggccc gacggcggcg cctggacctc cgtcccgggc gtcggcatgg
    19141 aaccggcctg caccggatgg atgcgcaagt ccgtcgatct cggcggcgcc acgaagctgc
    19201 gggccgcctt caacaacggc aacggcgtct gggacaacaa cgacggcacc gactacacga
    19261 tcccgtccgg ccgcagcacc gtggagaacg gcaccgtcac gggcggcgcc ggggacccgt
    19321 gcgccgccga ggccccggac accgaggcgc cgtccgtccc gtccggtgtc accgccgagg
    19381 ccgacggcac ctcggtcgtc ctcacctggg agccctccac cgacgaccgc gcggtcaccc
    19441 gctaccaggt gacccgcacc ggcggcggca ggggcaccct cgtcgccgac accggctcca
    19501 ccgtcttctc cgatacggac ctcgaggagc agaccgcgta ctcctacacc gtccgggccg
    19561 tggacgcggc cggcaacgtc tccgccgcct cgtccccggc cgccgtcacc accggcgcga
    19621 agccggccac ccccgccgcc gggaagccgc tgggcaccga tccgcgcaag gaccccatct
    19681 acttcgtcct caccgcccgc ttcaacgacg gcgacccggc gaacaaccgg ggcggcagcc
    19741 aacacgagaa gtccggcaac gcggcccacg acgaccccat gttccggggc gacttcaagg
    19801 gcctggtcga caagctcgac tacatcaagg ggctcggctt ctccgccgtg tggatcaccc
    19861 cggtcgtcct gaaccgctcc gactacgact accacggcta ccacggctgg gacttctacc
    19921 gggtcgaccc ccgcctggag tccgccggcg cctcgtacca ggacctgatc gacgcggccc
    19981 acgccaaggg catgaagatc taccaggacg tcgtgtacaa ccacagctcc cgctggggcg
    20041 ccaagggcct gttcaccccg accgtctacg gagtccgcga caccgactgg agctggtact
    20101 acgacgagcc gaacgacggc ttcgcgtacg acggcctgac cgtcgagccg aagtccggga
    20161 agtcgtacta caacggcgac ctgtggtcca ccgcggaacc ctccggcaac acctgcctcg
    20221 actggggcaa gccgaccggc ggcacctccc ccgagggcta caggctctac aactgccagt
    20281 ggccgaaccc gacttcgggc atgttcccga agacgtacta ccacaactgc tggatcggga
    20341 actgggaggg cgaggactcc cgctcctgct ggctgcacga cgacctcgcc gacttcaaca
    20401 ccgagaacgc gcaggtgcag aactacctga tcggcgccta cgacaagtac atcgacatgg
    20461 gcgtggacgg cttccgcgtc gacaccgccg tgcacatccc ccgcaccacc tggaaccgcc
    20521 gcttcctccc cgccatccag gaacgggtga cggcgaagca cggcgccgcg gcggcccgca
    20581 acttcttcgt cttcggcgag gtggccgcgt tcgtcaacga caagtggaac cgcggctcgg
    20641 tcaaccactc cgcgcagttc tacacctgga aggagcgcaa ggagtacagc gcggacgatg
    20701 ccgcggcggc cctggagatg tacgactggg agcaggcacg gggaccgtcg gaccagccga
    20761 tgtcacagaa cgccttcctc gacggcaaca cgtaccgcac cccggaccac agccggttct
    20821 ccggtatgaa cgtcatcgac atgcgcatgc acatgaactt cggtgacgcc cgcaacgcct
    20881 tccacaacgg caaggacagc gacgacagct acaacgacgc cacgtacaac gtcgtctacg
    20941 tcgacagcca cgactacggc cccaacaaga gcagcgaccg ctacgcgggc ggcaccgacg
    21001 cctgggccga gaacatgtcg ctgatgtgga ccttccgcgg catcccgacg ctctactacg
    21061 gctccgagat cgagttcagg aagggccaga agatcgactg cgggccttcc tgcccgctgg
    21121 cggacaccgg ccgcgcgtac ttcggcggcc atctggccgg cgaggtgaag gcgtccggct
    21181 tcggcacggt ggagtcggcg agcggagagg tcgcggacac cctcgcccag ccgctcgccc
    21241 ggcacgtgca gcgcctcaac ctgatccgcc gggccgtccc cgccctgcag acgggccagt
    21301 actccaccga gggcgtcagc ggcgacatgg cgtacaagcg ccggtacacc ggcggcggca
    21361 cggacagctt cgcactggtc acggtcacgg acggggccac gttcagcggc atcccgaacg
    21421 gcacgtacac cgacgccgtc accggcgaca cgcggcaggt caccgacggg gaactgacgg
    21481 tcggcgcccc cgggaagggc aatctgcgcg tctacgtcct ggacctcggc ggcacgaacg
    21541 cggcccccgg caaggtcggc accgacggac cgtacctgaa gtagggcgcg ggggcccggg
    21601 gtcggacggc gtcctccgcc gcccggcccc aaggccccgt tcccccgacc gagttaccgg
    21661 ccccgtgtca ccggccgcac ccacggcccg ccgggcggac agagtgcacc atcgtgcgcg
    21721 aaagcgacca gaaggagcac tgatgtaccg cacgcacggc atgtgccacg gcaccggcct
    21781 ccgccgggcg gccctgaccg gcgccgccgt cctgaccgcc ctcgccctga cggcgggcac
    21841 cgcgtcggcc ctgcccgccg ccccggagga ctcccggagc ccccgggacg cacaggggac
    21901 cggggccacg cagaacccgc acggcgcgga ggccccgcgg aacccgcaga acgctcggac
    21961 ggcgcagggc cggacggtgt cgttccgcac ccaccgcgcg ggcgcgtact tctaccactt
    22021 ccgcgagaag ctggtggtct ccgactacaa ggccgacggc tacggcgccc gcgcctatct
    22081 gacctggggc tcccgccgcg cctccgtcta cgccggcggg ggcaggaact ccaccgacga
    22141 gaaggatctg agcatcaagg agggcacccc ggtgtggctc cagctctgca ccacgaaacg
    22201 cggcaagaac atccgctgca ccaagacccg caagggctac gcctgaccgc gccccgcccg
    22261 cccgccggcc ccgccacccg ccctccccac cgggggtgcc ctaccggccg tagagcttca
    22321 gccccacatg gtcgacgatc cagcggtacg actcgctgtc gatcgcgaag tagatgcgcc
    22381 cgacgcggtc ggg
//
