LOCUS       NZ_CP023202            26329 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1071460
            Orig. end                         :: 1097789
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26329
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="9"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26329
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26329
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16329](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16329
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(241..1329)
                     /locus_tag="SXIN_RS04600"
     CDS             complement(241..1329)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469264.1"
                     /locus_tag="SXIN_RS04600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing redox enzyme family protein"
                     /protein_id="WP_095756620.1"
                     /transl_table=11
                     /translation="MATGATTTPGTAGRTRAGSAGGAGTAAGGPPLPAPRGDLSAAVTA
                     LLTGGSRDLPGGPAVTAADPYGDDLQLALYLAYELHYRGFAGVGGHWEWDPDLLRLRRA
                     LEERFLSALRADTPRPESAAAALDALLAEPVDGDGVSHRLQDSGELWQLREYAAQRSLY
                     HLKEADPHAWVIPRLTGRAKAAMVAVEFDEFGGGRADRVHARLFAELMTDLGLDPAYGR
                     YLDVTPAPMLAVVNQMSLFGLHRALRGALVGHFATVEITSSPGSRRLAKALERAGAGPA
                     AVHFYTEHVEADAVHEQIVRRDVVGGLLEEEPGLDADVAFGAASTESLEDRLGGHLLAA
                     WEAGRTSLRAPLPAPPPVPAPA"
     misc_feature    1519..1537
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            1547..1960
                     /locus_tag="SXIN_RS04605"
     CDS             1547..1960
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987085.1"
                     /locus_tag="SXIN_RS04605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SsgA family sporulation/cell division regulator"
                     /protein_id="WP_019706668.1"
                     /transl_table=11
                     /translation="MFPVIDRAVQAGLITSDGQVMDVPAALRYRRDDPLAVRACFPPRA
                     SLGGADVTWVFSRDLLAAGLLEPVGDGDVHVRPFGPLVTVLEFHAAAGTALVRMDSADV
                     RSFLEQTYALVPFGREELHLDLDGDLAALLREA"
     gene            complement(1985..2713)
                     /locus_tag="SXIN_RS31945"
     CDS             complement(1985..2713)
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568693.1"
                     /locus_tag="SXIN_RS31945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_095756621.1"
                     /transl_table=11
                     /translation="MTPGSRSPRSLAARLCLLARAPESVRPGTGGADGADRLPPLVRAG
                     ALTELARRGLLTDDGGVVTPDLDARTDDPALDDLLELITESPPHGWRDWVTRHAGTTLD
                     AVQAGLAGEGALRVVSRRWLGLLPPRDYALVDGEAAWALRADARRALHGREPVARVAPE
                     DAALAVLAAAAGLTGVVSAQERTARGRRLGELARRAGQCGPAGGPAAVAPVRAVAEVRA
                     GLAAAVAAPEGSAAASAAGG"
     gene            3135..4751
                     /locus_tag="SXIN_RS04615"
     CDS             3135..4751
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546858.1"
                     /locus_tag="SXIN_RS04615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_019710792.1"
                     /transl_table=11
                     /translation="MAPSALSVSCSDLSFTWPDGTTVLDGLDLAVGPGRTGIVGLNGSG
                     KSTLLRLIAGELRPSGGTVRVTGETGYLPQNLTLDTALRADVALGIAAPRAALRAIEAG
                     DPSEEHFTAVGDDWDIEERALATLDQLGLGHIGLDRTVGELSGGESVLLRLAALLLRRP
                     GVLLLDEPTNNLDLRARRRLYEAVSSWRGVLIAVSHDRELLELVDRIGDLREGGVHWYG
                     GGFSAYQEALTAEQEAARRSLRAAEADVRRQKRELAEAREKLARRVRYGRKMYENKREP
                     KIVMNARKRAQQVSAAKHRGTHTARLEDARERLDEAADAVRDDAEIRVDLPHTAVPPGR
                     TVLTVREAELRYGARVPEFTVRGPERIALTGRNGAGKTTLLRTIAGELEPVRGEVRTEV
                     PSRFLSQRLDLLDDGLSVAENVARHAPSATGNRIRARLARFLFRGARADQPAGTLSGGE
                     RFRATLAALMLAEPAPQLLMLDEPTNNLDLSGVEQLTAALESYEGALIVAAHDLPFLRS
                     LGITRWLHLDGDLTEAAPEDV"
     gene            4965..5936
                     /locus_tag="SXIN_RS04620"
     CDS             4965..5936
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010473828.1"
                     /locus_tag="SXIN_RS04620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-ACP desaturase"
                     /protein_id="WP_019710793.1"
                     /transl_table=11
                     /translation="MTQTPAPLAGSEGWSDAKLLYALEEVVEDELNRHLTVAKDWMPHE
                     YVPWSDGRNFDGPLGGEAWAPEQSKVSDIGRIALVVNLLTEDNLPSYHHEIATLFGRDG
                     AWGTWVHRWTAEEGRHGIVMRDYLLTSRAVDPVQLEEFRMAHMSEGFESDNRHSMLHSV
                     AYVAFQELATRISHRNTGHHSGDPVCDRMLSRIATDENLHMVFYRNLLGKAFELAPDQT
                     MEAVRDVVVGFRMPGHGMPGFERAAAQMAIGGIYNLRIHHDDVLQPVLRFLKVLEISGL
                     GPEGLKAQEELGMYMGGLDAQATKFDERREALLARRAARKAS"
     gene            6227..6415
                     /locus_tag="SXIN_RS31715"
     CDS             6227..6415
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024412.4"
                     /locus_tag="SXIN_RS31715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_019710794.1"
                     /transl_table=11
                     /translation="MARYRAEGEAAFEPRSRRPKTSPTAPETETVELILRLRKGLTEQA
                     VGRGGGGIDHDGPGECQ"
     gene            complement(6491..7030)
                     /locus_tag="SXIN_RS04630"
     CDS             complement(6491..7030)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337821.1"
                     /locus_tag="SXIN_RS04630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyltransferase"
                     /protein_id="WP_019710795.1"
                     /transl_table=11
                     /translation="MTTAPAIELRTFTTLDTARGDLLDVYADVRAPLLHLPNYAVTAFG
                     ERLDRHGTEPGFTAVLAYADGHSVGYAYSNTIEHGDRYWQRTSPTPAEKYTERPAVALK
                     EIGVRPIWRKTGTARRIHDALLATRDEPYVTLMVNPAAGDGKVHALYKSWGYEDIGQSQ
                     PSPASPVLTVMIRASR"
     gene            complement(7027..8310)
                     /locus_tag="SXIN_RS04635"
     CDS             complement(7027..8310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000004.1"
                     /locus_tag="SXIN_RS04635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_095756622.1"
                     /transl_table=11
                     /translation="MDTTRNTVFEAWMTEHGYSSNSLAEAVNRAIERLTGRPGGLDGSS
                     VRAWKAGRVAWPKSASRKALEDVSGLPAVALGFVPRGRPSSTPAPPQQEDPDMKRRTLV
                     GSIAAAAAAAAAPGTASPRRIGMSDVNRLNKRFAEIIASDHCHGGQLGIEQRASSLADE
                     ALNLQNAGSATQRVRSNLYASAAAFRSSAMWAAIDGRRYDVAKAHMREAQALAEMSGDQ
                     AIKFRIWSHAGTMYRHLGRPADASAANDVARNLHLTRRDPMFASLGLARQGAIQGTAQD
                     RTGTRRAFDQAQDAMLRADPADYRPVWMLAFYDQAELDSLALSAHLALGDYSTAEYHAH
                     RCLSALRSHMVRSRAITTTRLAHAQLAQGAPDAATATAMKVPSEAATQHARVTRMLQEF
                     GAGLRATAPGTSTVQTWTEHTATWRMAA"
     misc_feature    complement(8083..8085)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8552..8998
                     /locus_tag="SXIN_RS04640"
     CDS             8552..8998
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982947.1"
                     /locus_tag="SXIN_RS04640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_019710797.1"
                     /transl_table=11
                     /translation="MTSLRTPVEALSVGHPTYTQTFPCEATTAEIGRELVRDLLSVWHL
                     DGLADRAALIVTELIANASRHTPCPEVRLTVGRPDATRLRIGIVDREASRLPILSQAAD
                     DDESGRGLLLVDAVADRWGYDLHGSGRRPWGKEVWAELRTEGGK"
     gene            9226..9414
                     /locus_tag="SXIN_RS31950"
     CDS             9226..9414
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000002.1"
                     /locus_tag="SXIN_RS31950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_039823161.1"
                     /transl_table=11
                     /translation="MERPWITGDCWLGCGRTGVLVIWLGPVQWDGHHAPFYSCEPCLDR
                     LKAQALAYFMERRPASA"
     gene            9604..9783
                     /locus_tag="SXIN_RS04650"
     CDS             9604..9783
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825826.1"
                     /locus_tag="SXIN_RS04650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_016825826.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.3e-13, bitscore:
                     47.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSTVVPSRTEVRPQIPGASDGFDLDVSLVEIADPAGLVNLTDD
                     NCGSTCGACTTNVA"
     gene            10001..12955
                     /locus_tag="SXIN_RS04655"
     CDS             10001..12955
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543779.1"
                     /locus_tag="SXIN_RS04655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_019710799.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.4e-196,
                     bitscore: 651.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2e-18,
                     bitscore: 65.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.1e-22, bitscore:
                     77.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAWLRAVWADQDVAEALQHSSPVLAAQVRALCTAEHPALRDVQRA
                     ALSVARYLLRAQRRATPFGLFAGVATAEFGPHARADWGEEHVAVGRAGAEWLAALVARL
                     ESCPDLLERLPVVINNTVTYRGDRLIVPFQPDVQDDRTRAVEASLALTGPVRAVLAATR
                     LPIRFGTLVDKLQAEFPEAGPEKAGQLLTELIRRRVLITGLHAPSTEVDALGYLLGQLD
                     AIDAGRLAPVAETVRELHAVRAGLEECTTRGGRDSAAARMRDLVPGLRRHPIALDLRLD
                     ARIVLPEAVAREIERAALILTRLSIRPYGTAAWNEYHQRFYERYGIGTMVPLAETVADS
                     GTGYPDGYPGAPADARRPRVSARDDALVRLAQAAVLDGRDEVILTDEQIEALDVGPDEP
                     RLPPHLEIVVRVHAASLEELQRGRFRLEVVSVSRGAGVSTGRFLSALAPADREALVTEL
                     ADLPAADGNTMPAQLSFPPLLSESAHVTRSPQVLPTVISLQEHRAPQDTILTPKDLAVG
                     CDGRRMYLAVPERGHRVEAVGMHSLNLRTHTPPLVRFLTELSRAQCAQVTIFDWGAATA
                     MPFLPRLRYGRIVMAPARWRLEASELPGHARPRAEWDAALSDWRARRRRPRRVYLVEDD
                     RRLFLDLDEAGHRALLRRHLDRTRLAVLVEAPEPEAYGWCGGRAHEVVVPLKATRPSTW
                     PPLPAPGRARALSAAQMQTPASSSVLLAALYGDPRRQDVLLFRHLPGLLEQLGNPPWWF
                     IRFRDPDQHLRVRIALPDPEAFADTARTVSAWADELRSIGLMADLRYPTSYREMGRWGS
                     GTAWEAAEEVFRADSRAVLAQLAQPQRPGLRTLVAAHTVAIASAFLGSTAAGMRWLIDH
                     IPPTAPKPVPRPQFTEAVRLADPSDDWSALRSVPGGDAIVSGWADREAALAAYRPHLPG
                     PDTQGIAVDDVLTSLLHVHFVRHVAVNFPEEEVCLYLARAAALAWTARTRGRAS"
     aSDomain        10346..10621
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SXIN_RS04655_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="9.10E-21"
                     /identifier="RREFam001.1"
                     /label="SXIN_RS04655"
                     /locus_tag="SXIN_RS04655"
                     /protein_end="207"
                     /protein_start="115"
                     /score="65.4"
                     /tool="antismash"
                     /translation="VVINNTVTYRGDRLIVPFQPDVQDDRTRAVEASLALTGPVRAVLA
                     ATRLPIRFGTLVDKLQAEFPEAGPEKAGQLLTELIRRRVLITGLHAP"
     gene            12952..14226
                     /locus_tag="SXIN_RS04660"
     CDS             12952..14226
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543780.1"
                     /locus_tag="SXIN_RS04660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_019710800.1"
                     /sec_met_domain="LANC_like (E-value: 4.2e-43, bitscore:
                     145.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAYPALGLVDAIAAQLADPDTVPLGSRTLSSDRQHLAYGPPGIA
                     LLHVELAANGLGPWHRAHYWLTAASRQPLTSGSDSHPFYGVPAFAHALSCAADHLPGSY
                     QRALDAMDGQIAVDVGRRLDAAHRRIDAGRLPQLAEFDVIRGLTGYGAYLLRRNPGSST
                     MRAVLDYCVRLTEPITHHGETLPGWWAETGPSGSPDDRFPGGHANTGMAHGIGGVLALL
                     ALAARNGSVIDGHHAALRTILAWLDRWKEKADGGPVWPYWVTQGELRRGGLVPSAPRRP
                     SWCYGTAGLARAQQLAALALGDTSRQIDAENALVAALTDLEQLKTTTDNGLCHGFAGLA
                     HTATRTADDAHPSTAGRLRAAIPALLAAVTPPGTDPELMATALIQDEKDGPGLLDGAAG
                     TALALLAPSTAAPPQSAWDACLLIS"
     gene            14248..16329
                     /gene="fxlM"
                     /locus_tag="SXIN_RS04665"
     CDS             14248..16329
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="SXIN_RS04665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_019710801.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.8e-25, bitscore:
                     86.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.9e-45, bitscore: 153.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDRWQQHNITFFDRESARRTIAERVGPALIQAETDGQLTSWWF
                     MNKQPWPLRYLAGKPSPAIESLLSDLIGDGVAVSCLPGIYEPETDTFGGPEAMDAAHEL
                     FHSDSRHLLTYQPNPMHLGRRESAVLLASVMMRGAGLDWFEQGDVWAKVAALRPATAPQ
                     PPERAAELTPAMRKLMTADAYSVCRLGGPLHAHQEWVTAFEQAGATLAELAGCGALTRG
                     LRAVIAHHVIFHANRAGLLRDDQSALSHIAREVVMGTSDHTESPTEATADIDSVGAVNT
                     DTITTPTAGAERLRNALVEQLRADGHARTPAVEAALRTVPRHVFVPEASLEDAYANAPV
                     HIKYDTDGTSISCASQPGVVALMLDQLDAQPGERILELGAGTGYNAGLLAHLVGENGHV
                     TTLDVDDDLVEGARTHFAAAGITNVEAVTRDGALGYAEGAPYDRIIATVGAHGVPHAWL
                     QQLAPGGRLLVPQRLKGTVSRSIAYEQRDGRWASLGSEMNTFMPLRRGIADDDRRVIPL
                     STDGAVRLQAPAGLSIDADALAGVLDQPRTEEWTGMTVRAMESPEWMELFVTCSLPSGL
                     IRMLFPQSAKGTLLTEDPYPSSTAVVDKGSVTYLARRVSKEKTPEGGKLWEFGVIGHGP
                     GSDELAAKVADSIRTWDRDYRDREATFKIQPLDAPEIEQRPGLFALDTPLNRIVVDWR"
     misc_feature    16359..16372
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            16419..17552
                     /locus_tag="SXIN_RS04670"
     CDS             16419..17552
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982953.1"
                     /locus_tag="SXIN_RS04670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019710802.1"
                     /transl_table=11
                     /translation="MDPHGPIAQRFPLVARFRPACLPLPARVRALVDLADTAVEQTDQG
                     LASAVYNQAALIASDLDLPDLAREMCHQHAAAYLHACPLPGMSAIRGLEPVVNLARLQI
                     RAGRADEGRQRLLDLHKAVEAGTTVRFEGINVPADLTATGEDRQEVRAWLWRVLLADGT
                     RTLTTEGRWAEALTHIEAHHGIGKRMLDGRQVAVLAALAAGDTAWASDLLADTMPGDPW
                     EQAVTACLTVLCRRDAGQPIDGHLADVVTAYLGRKTEPGMTVFDTRLGLTVLDAIGSAE
                     ALAAHRIVEDLHRRTTDAEDGYAARENLAHPLFTEIATDRQVQDCRALVRACALGAGTL
                     PDELRGELTAALQASDSVIRESVVRSSDLEGTQPLRF"
     tRNA            complement(17666..17739)
                     /anticodon=(pos:complement(1089163..1089165),aa:Met,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SXIN_RS04675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Met"
     gene            complement(17666..17739)
                     /locus_tag="SXIN_RS04675"
     gene            complement(17835..18116)
                     /locus_tag="SXIN_RS04680"
     CDS             complement(17835..18116)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612663.1"
                     /locus_tag="SXIN_RS04680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_039823165.1"
                     /transl_table=11
                     /translation="MTCMLIEFIGPAEHASGWRERALCAQTGPDFFFPVPGGSTREAKQ
                     VCRACEERVECLEYALENDERFGVWGGLSEKERRRLRKSRRSGGSGTS"
     gene            complement(18297..19340)
                     /locus_tag="SXIN_RS04685"
     CDS             complement(18297..19340)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174340.1"
                     /locus_tag="SXIN_RS04685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_050930569.1"
                     /transl_table=11
                     /translation="MTESAGAQPLGRPGPSTSPTLEQVARAAGVSRATASRAINGLPYV
                     SEKAREQVAHAVEVLGYRANQVARSLATRRTGSIALVMSEPGNFVLSDPFFARVLRGIY
                     SGLSGSQLQLVLLMTNEQDEDGFARYLCGGHVDGALVVSLHGEDPLPSLLVEAGLPVVL
                     GGRPLVRVDAPYVDVDNFNGACLAARHLIDTGRTRVATIAGPADMAVGMDRLSGWRRGM
                     AGTGFATDAVAHGDFTVEGGAAAMRRLLQSHPDLDAVFAASDLMAVGALQTLQAAGRRV
                     PEDVAVVGFDNLDIAATASPPLTTVRQPIEEFGRTMTWRLLAQLSGEAGLPPSILLQTE
                     LVRRESA"
     misc_feature    complement(19615..19629)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.57"
                     /tool="antismash"
     misc_feature    19616..19630
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.57"
                     /tool="antismash"
     misc_feature    complement(19617..19628)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.79"
                     /tool="antismash"
     gene            complement(19812..20711)
                     /locus_tag="SXIN_RS04695"
     CDS             complement(19812..20711)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057324.1"
                     /locus_tag="SXIN_RS04695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrolase"
                     /protein_id="WP_238153673.1"
                     /transl_table=11
                     /translation="MSSPTTSRSSSSPGLPDSPVPPPAGSAPPRSARPTRRRQILAASA
                     TVLALTAAGATGSASAAGPSAGDRPAAACDASGFCEDFESQTGTAPSGRWTAGAANCTG
                     TGTATVDSGTAHTGSKSLRIDGGEGYCNHMFASTPLDEVAGSSSLHVRFWVRHTTALPA
                     AHVTFAALKDANDGGKDLRMGGQNGALQWNRESDDATLPEQSPVGVSKSMPLPVNEWTC
                     VEFGIEGSTLETRVNGSVVEGLVIDGTPTHDIDRQWLNKPDWRPSLTDLRLGWESYGNG
                     ADTLWYDDIAVGTAPIGC"
     gene            complement(20978..23590)
                     /locus_tag="SXIN_RS04700"
     CDS             complement(20978..23590)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0008810 - cellulase activity [Evidence
                     IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179471.1"
                     /locus_tag="SXIN_RS04700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 48 protein"
                     /protein_id="WP_238153674.1"
                     /transl_table=11
                     /translation="MRSHLRRRLRPGPVTGGLALAALVAGVVPGTTFASEAAGSAEAQA
                     IGVALTSSETGADNYALAPEGVPLKAKTTGDVAKVEFYADSKLLATDSKAPFEGEWKNA
                     PEGQYSITAKAYDKDGKPAGSHPSLVNVLEKPAVIASPVARQVKQGGETTVGIKLSAKP
                     SSDVRVTLERASGTKDISAAKSELTFTPENWDRVQQVPVNSADTTGDLAKAVFKATAAG
                     HDAGTVPVQEISPQASEYQQDFLDLYNKINDPSSGYYRTFNGLKVPYHAIETLIVEAPD
                     HGHETTSEAFSYYLWLESEYGRITEDWGPFNDAWASLEEFAIPGTEDQPTNGAYDASSP
                     ATYAPEHPSPTEYPAKLDSGVSVGQDPIAGELKSAYGTDEIYGMHWLLDVDNTYGFGFC
                     GDGETAPAFINTFQRGSQESVWETVTQPSCDTFAHGGENGFLDLFTDDAEYAKQWKYTN
                     APDADARAVQVAYQAKKYAEEQGKGGEVADVVDNAVKMGDYLRYAMFDKYFKKIGNCTS
                     PSCPAGSGKDSAHYLMSWYYAWGGANQDAQYPWAWRIGDGAAHQGYQNPMAAYALAEDP
                     DMKPKSSSGQADWAKSLDRQLEFLQWLQSSEGGIAGGATNSWDGQYASPPSNASTFYGM
                     YYDWQPVWHDPPSNRWFGFQVWGLQRTAELYAETGDERAGKIMDKWVDWALENSTIDGT
                     GNYQIPSDLEWSGQPDTWNASNPGSNSGLHVEVLNHTNDVGVAASFAKTLLYYAAGSGD
                     AEAREAGEGLLDGMLAHKDDLGIAIPEVRKDYDRFEVTSGEDKLYIPNGWTGTMPNGDE
                     INSDSTFLSIRSFYESDPDFPKVQQYLNGGSAPEFTYHRYWAQTEIATAFAAHDALFG"
     misc_feature    23931..23942
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     misc_feature    23976..23987
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.47"
                     /tool="antismash"
     misc_feature    complement(24174..24188)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    24175..24189
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    complement(25056..25070)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    25057..25071
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.69"
                     /tool="antismash"
     gene            25129..26148
                     /locus_tag="SXIN_RS04710"
     CDS             25129..26148
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018853989.1"
                     /locus_tag="SXIN_RS04710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_019710805.1"
                     /transl_table=11
                     /translation="MKKSSCAAAGAATLAVAAFLIPAPAGASEAGPAADSTYYVDPETQ
                     SAKWVAANPGDSRAAVIRDRIASVAQGRWFTTTNTGEVRAEVDAFVGDAQSAGQIPIMV
                     VYNMPNRDCGGASSGGAANHSAYRQWVDEIAAGLNGRPAAIIIEPDVLALMSNCQDASQ
                     QQATQESMAYAGKALKAGSAEAKVYFDAGHSRWHSPQEMASRLAASDIVNSADGISNNV
                     SNYNHTADEVAYSQAVLNAIGSNELTAVVDTSRNGNGPDARGEWCDPPGRAIGTPTTAD
                     TGQDRIDAYLWVKLPGEADGCAAAAGQFVPQLAYDMANAAPAASTPSSSRTASEDGAR"
ORIGIN
        1 gtggcgctgt gcacctgccg ccgcagccgc cgcttcccct ggtgcgacac cagtcaccgc
       61 cgacgggtcc gcggtaccgc ggacgagcac ggcgactccc ccggcgcagg ctccggctga
      121 ccccgcgaag gcgggtcccc ctccgccggc tgaccggctg accccttccg gcagctgccc
      181 ccttccggca gcggcgcccc ggccccccgt gggaccgggg cgccgggctg tcgcggccgc
      241 tcaggcgggt gccggcacgg gcggcggggc ggggagcggc gcgcgcaggg aggtgcggcc
      301 cgcttcccag gccgccagca gatggccgcc gagccggtcc tccagggact ccgtcgaggc
      361 ggcgccgaag gccacgtccg cgtccaggcc gggctcctcc tccagcagcc cgccgacgac
      421 gtcccggcgc acgatctgct cgtgcaccgc gtccgcctcg acgtgctcgg tgtagaagtg
      481 cacggcggcc gggcccgcgc ccgcccgttc gagcgccttg gccagccggc gggaaccggg
      541 cgaggaggtg atctcgacgg tcgcgaagtg ccccacgagc gccccgcgca gcgcccggtg
      601 gaggccgaac agggacatct ggttgaccac cgccagcatc ggggcgggcg tgacgtccag
      661 atagcgcccg taggcggggt cgaggccgag gtcggtcatc agttcggcga agagccgggc
      721 gtgcacgcgg tcggcccgtc ccccgccgaa ctcgtcgaac tcgacggcga ccatggcggc
      781 cttcgcccgg cccgtcagcc gggggatgac ccaggcgtgc gggtcggcct ccttgaggtg
      841 gtagagcgag cgctgcgcgg cgtactcgcg cagctgccac agctccccgg agtcctggag
      901 acggtggctg acgccgtcgc cgtccacggg ttcggcgagc agggcgtcca gagccgccgc
      961 cgcgctctcc gggcgggggg tgtccgcgcg cagggcggac aggaagcgtt cctccagtgc
     1021 ccggcggagg cggaggaggt ccgggtccca ctcccagtgg ccgccgaccc cggcgaagcc
     1081 ccggtagtgc agttcgtagg cgaggtagag ggcgagctgg agatcgtcgc cgtacgggtc
     1141 ggcggcggtg acggccggtc cgccgggcag gtcccgggag ccgccggtga gcagggcggt
     1201 caccgcggcc gacaggtcgc cgcgcggcgc gggcaggggc ggtccgccgg ccgcggtccc
     1261 ggctcctccg gcgctcccgg cccgggtgcg gccggcggtg ccgggggtcg tcgtcgctcc
     1321 ggtcgccatg gctccggacc tcctcttccc tcgtccccgg gggccgtccg ccccggggac
     1381 acatccgggt cgttcgagtg ccctccgccg cctcggtcat gcgttcgcgg aggccgcgga
     1441 ggagcggagt gacagaggtc acgctgccga tccgcacact gagagggccg ccggatcgtc
     1501 atagagagtg tcagccgtct tccgaacacc tctcaggagg caggagttgt tccctgtcat
     1561 cgaccgagcc gtacaggccg gcctcatcac gtccgacggg caggtgatgg acgttcccgc
     1621 ggcgctgcgc taccggcgcg acgatccgct cgccgtccgt gcctgtttcc cgccgcgcgc
     1681 ctccctcggc ggtgcggacg tgacctgggt gttctcccgg gatctgctgg ccgccgggct
     1741 gctggagccg gtcggcgacg gggatgtgca cgtacggccg ttcgggccgc tggtgacggt
     1801 gctggagttc cacgcggccg ccgggacggc gctggtccgg atggacagcg cggacgtgcg
     1861 gagcttcctg gagcagacgt acgccctggt gccgttcggc cgtgaggaac tccacctcga
     1921 cctcgacggc gacctggcgg ccctgctgcg cgaggcctga caccccctcc gccggagcgg
     1981 ccggtcagcc gccggccgcg gacgccgccg cggacccctc cggggcggcg acggccgcgg
     2041 cgagcccggc ccgcacctcc gcgaccgccc gcacgggcgc caccgcggcc ggccctccgg
     2101 ccggaccgca ctggcccgcg cgccgcgcca gttcgccgag ccgccgcccg cgggcggtcc
     2161 gctcctgcgc ggagaccacc cccgtcagcc cggccgccgc ggccaggacg gccagcgccg
     2221 cgtcctcggg cgccacccgc gccaccggct cccgcccgtg cagcgcgcgc cgcgcgtccg
     2281 cccggagagc ccacgccgcc tccccgtcca ccagggcgta gtcccggggc ggcagcagac
     2341 ccagccaccg ccgggacacc acgcgcaggg cgccctcccc ggcgagcccg gcctgtacgg
     2401 cgtccagggt ggtgccggcg tgccgggtca cccagtcccg ccagccgtgc ggcggggact
     2461 cggtgatcag ctccagcagg tcgtcgagtg ccggatcgtc cgtccgggcg tcgaggtccg
     2521 gtgtgacgac tccgccgtcg tcggtgagca gcccccgccg ggcgagttcg gtcagcgccc
     2581 cggcccgcac caggggcggc agccggtccg cgccgtccgc accgccggtc ccggggcgga
     2641 cgctctccgg ggcccgggcg agcaggcaga gccgggcggc gagggagcgg ggcgaacggg
     2701 aaccgggggt cacatgggcc tcctgcggat cgggcggccg gtgcggccgg tggcggtggc
     2761 gagcgccgcg gagggccggc gacggtgccc cgggccggtc ggcggggtcc cgcggacccc
     2821 ttgcgggccg gccccggccg cacgggcggc aattccgttg ccgccgcccg gccgtctccg
     2881 taccgtggtc accggccctg ttgtcggcgg acggagaagg cgttgctcgt ctgaggtcat
     2941 gggacaccgt gtgccacgcc ccggccggaa ggccggaccg gcgtgggccg ttgtgcgacc
     3001 tcggcaccga gccgcccgcc ccgaccgggg cttcttctct ggttgttctc tggtgcccct
     3061 cttccgccac ggcattcccg gtgtctcctc cgctgccccg taccccgtgc accccggcga
     3121 ccaggaggcc ccgtatggca ccgtccgctc tctccgtcag ctgctccgac ctctccttca
     3181 cctggccgga cggcaccacc gtcctggacg gcctcgatct cgccgtggga ccgggccgca
     3241 ccggcatcgt cgggctcaac ggctccggca agtccaccct gctccgcctg atcgccggtg
     3301 agctgcggcc gtccggcggc acggtgcggg tcaccggcga gaccggctac ctgccgcaga
     3361 acctcaccct ggacaccgcg ctccgcgccg acgtggcgct cggcatcgcc gccccccggg
     3421 ccgccctgcg cgccatcgag gccggcgacc cgagcgagga gcacttcacc gccgtcgggg
     3481 acgactggga catcgaggaa cgggccctgg ccaccctgga ccagctcggc ctgggccaca
     3541 tcggtctcga ccgcaccgtc ggcgagctct ccggcggcga gtcggtgctg ctgcggctgg
     3601 cggccctgct gctgcggagg cccggcgtcc tgctgctcga cgagccgacc aacaacctgg
     3661 acctgcgcgc ccggcgccgg ctgtacgagg cggtgtcctc ctggcggggc gtgctgatcg
     3721 ccgtcagcca cgaccgcgaa ctgctggagc tggtcgaccg gatcggcgat ctgcgcgagg
     3781 gcggggtgca ctggtacggc ggcggcttct ccgcctacca ggaggcgctg acggccgagc
     3841 aggaggccgc ccggcgctcc ctgcgcgccg cggaggccga tgtgcggcgg cagaagcggg
     3901 agctggccga ggcccgggag aagctggccc gccgggtccg ctacggcagg aagatgtacg
     3961 agaacaagcg cgagcccaag atcgtgatga acgcccgcaa gcgcgcacag caggtctccg
     4021 ccgccaagca ccgcggcacc cacaccgcgc ggctggagga cgcgcgcgaa cggctggacg
     4081 aggccgcgga cgccgtgcgc gacgacgccg agatccgcgt cgacctgccg cacaccgccg
     4141 tcccgccggg ccgcaccgtg ctcaccgtgc gggaggcgga actccggtac ggcgcgcggg
     4201 taccggagtt caccgtgcgc ggccccgagc ggatcgcgct gaccggcagg aacggtgcgg
     4261 gcaagaccac cctgctgcgg accatcgcgg gcgaactgga gccggtgcgc ggcgaggtgc
     4321 ggaccgaggt gccgtcgagg ttcctgtccc agcggctgga tctcctcgac gacgggctga
     4381 gcgtcgcgga gaacgtggcc cggcacgccc cctcggccac cggcaaccgg atccgggccc
     4441 ggctcgcccg cttcctcttc cgcggtgccc gcgccgacca gccggcgggc accctctcgg
     4501 gcggcgagcg cttccgcgcc accctggcgg cgctgatgct ggccgagccc gcgccgcagc
     4561 tcctgatgct ggacgagccg accaacaacc tcgacctgtc cggcgtcgaa cagctcacgg
     4621 cggcactgga gtcgtacgag ggcgccctga tcgtggccgc ccacgacctg ccgttcctgc
     4681 ggagcctggg catcacccgc tggctccatc tggacggcga cctgacggag gcggccccgg
     4741 aggacgtctg agaggtctgg tgagaggtct gagaggggag agggggtgcg gacggcggct
     4801 ccggaccggt gcaccggccg caacaccacc gccgtcaccc gacattacgg gatctaccct
     4861 ccgattagcc gcgcccccct ggtcccgggc ttcccccagt gcttaaccta cggtttcgta
     4921 acctacggag ccgtaggtga tccgcacgtc tccaggagct cgttgtgacc cagacccccg
     4981 cccccctcgc cggctccgag gggtggagcg acgccaagct gctgtacgcg ctggaggagg
     5041 tcgtcgagga cgaactcaac cggcacctca cggtcgccaa ggactggatg ccgcacgaat
     5101 acgtgccgtg gagcgacggc cgcaacttcg acggcccgct cggcggcgag gcctgggccc
     5161 cggagcagtc caaggtcagc gacatcggcc ggatcgccct cgtggtcaat ctgctcaccg
     5221 aggacaacct ccccagctac caccacgaga tcgccaccct cttcggccgc gacggcgcct
     5281 ggggtacctg ggtgcaccgc tggaccgccg aggagggccg gcacggcatc gtgatgcgcg
     5341 actacctgct gacctcccgg gccgtggacc cggtgcagct ggaggagttc cgcatggcgc
     5401 acatgtcgga ggggttcgag tccgacaacc ggcacagcat gctgcactcc gtcgcctacg
     5461 tcgccttcca ggagctggcc acccgcatct cgcaccgcaa caccggccac cactccggtg
     5521 acccggtctg cgaccgcatg ctctcgcgga tcgccaccga cgagaacctg cacatggtct
     5581 tctaccgcaa cctgctcggc aaggcgttcg aactggcgcc ggaccagacg atggaggccg
     5641 tccgcgacgt cgtcgtcggc ttccggatgc ccggccacgg gatgcccggg ttcgagcggg
     5701 ccgccgcgca gatggccatc ggcggcatct acaacctccg catccaccac gacgacgtgc
     5761 tccagccggt gctgcgcttc ctcaaggtgc tggagatctc cgggctcggc cccgaagggc
     5821 tcaaggccca ggaggagctg gggatgtaca tgggcggcct cgacgcgcag gccacgaagt
     5881 tcgacgagcg gcgcgaggcc ctgctcgccc gccgcgccgc ccgcaaggcc tcctgacgca
     5941 ccacccggcc gtcttcccgg ctccggctcc gcccggagcc gggcgggtcc ggcaacgcgt
     6001 cgggcccggt gcgctgtgcg caccgggccc gacgtctccg tagcggggac agtgtgctcg
     6061 ctcaggacat cggaatgggg tgtctcaaga catcggcatg acccaggggt catggtctgg
     6121 cgatgtcgaa gagacgtctg gtgattactg ctgtcgtccc ggagggccgc acgcagggcg
     6181 aagtggcgcg agcgtacggg gtgtcgcagg gctggtcagc cgcctggtgg cccgctaccg
     6241 cgctgagggc gaggcggcgt tcgagccgcg ctccagacgg ccgaagacct caccgaccgc
     6301 gcccgagacc gagaccgtcg agctgatcct ccggctccgc aaggggctga ccgagcaggc
     6361 tgtcggccgc gggggcgggg gcatcgatca cgacggtcct ggagagtgcc agtgatggcg
     6421 gtcaggcgct cgaccgagac gtcatcgggt acgcaggcgc gatacctcaa tgcgtgccat
     6481 atggcgcctg tcatcggctg gcgcggatca tcacggtgag gactggtgag gccggtgaag
     6541 gctggctctg tccgatgtcc tcgtaccccc acgacttgta gagggcgtgg actttcccat
     6601 ctccggcggc cgggttgacc atgagcgtga cgtacggttc gtcgcgtgtg gcgaggagag
     6661 cgtcgtggat gcggcgggcg gtgccggtct ttcgccagat cggtcggacg ccgatctcct
     6721 tcagggccac ggctgggcgc tcggtgtact tctccgcagg tgttgggctg gtgcgttgcc
     6781 agtaccggtc gccatgctcg atggtgttgc tgtaggcgta gccgaccgaa tgtccgtccg
     6841 cgtacgcgag gacggctgtg aatcccggct cggtgccgtg ccggtccagg cgttcgccga
     6901 atgcggtgac cgcgtagttc ggcaggtgga gtagtggggc gcgcacgtcg gcgtacacgt
     6961 cgaggaggtc gcctcgggcg gtgtcgagag tcgtgaacgt gcgcagttcg atggcgggcg
     7021 ccgtggtcat gcggccatcc tccaggtggc ggtgtgctcg gtccaggtct gcacggtgga
     7081 ggtgcccggc gcggtggcgc gcagtccggc tccgaactcc tgcagcatgc gcgtgacccg
     7141 ggcgtgctgg gtggcggctt cggaggggac cttcatcgcg gtggccgtgg cggcatcggg
     7201 ggcgccctgc gcgagctggg cgtgcgcgag ccgggtcgtg gtgatggccc gggaccggac
     7261 catgtgggac cgcagggcgg acaggcagcg gtgggcgtgg tactcggcgg tcgagtagtc
     7321 gccgagcgcc aggtgcgcag agagggccag ggagtccagt tcggcctggt cgtagaaggc
     7381 gagcatccac accggccggt agtcggcggg gtcggcgcgc agcatggcgt cctgcgcctg
     7441 atcgaacgcc cggcgggtgc cggtgcggtc ctgcgccgtg ccttggatgg cgccctggcg
     7501 ggccaggccg agggaggcga acatggggtc tcggcgagtg aggtgcaggt tgcgggcgac
     7561 gtcgttggcg gcggacgcgt cggcgggccg acccaggtgc cggtacatgg tgcccgcgtg
     7621 gctccagatg cggaacttga tggcctggtc gccggacatc tcggcgaggg cctgggcctc
     7681 gcgcatgtga gccttggcca cgtcgtagcg ccgaccgtcg atggcggccc acatcgcgga
     7741 ggagcggaag gcggctgcgg aggcgtagag gttgctgcgt acgcgctggg tggcgctgcc
     7801 ggcgttctgg agattgagcg cctcgtcggc gagggaggag gcccgctgct cgataccgag
     7861 ttgtccgccg tggcagtggt cgctggcgat gatctctgcg aagcgcttgt tgaggcgatt
     7921 gacgtcgctc atgccgatgc ggcgcggcga tgcggtgccg ggtgcggctg ctgctgcggc
     7981 agccgccgcg atgctgccga cgagggtacg gcgcttcata tcggggtcct cctgctgcgg
     8041 tggggcgggg gtggacgaag gccggccccg tggcacgaac cctaaagcga cggcgggcag
     8101 gccgctgacg tcctcaagtg ccttacggga ggctgacttt ggccacgcga cccggcccgc
     8161 tttccatgct cggaccgatg agccgtcgag tcctccgggg cgcccggtca accgctcaat
     8221 ggccctgttc acggcctcgg cgaggctgtt ggagctgtag ccgtgttcgg tcatccacgc
     8281 ctcaaaaacg gtattgcggg tggtgtccat gcgggcacgg tagtccgcgc gatccccgcc
     8341 cgccaggtaa agcagaggtc aaaacgccct aggtcggtcc gtcggctgaa cctctgaacg
     8401 tcctaaccaa ccagctgggc aagggagttg tatgggcacc ggtcgccctc tacgccgcac
     8461 cgtgcgggtg gctgttgacg gcccggccgg cccctgaggt tcccccgcgg gggtgggccg
     8521 ggcgccgaca cgacacgaag gctccacccc aatgacgagt ctgagaacac cagttgaggc
     8581 cctctccgtc ggccacccca cgtacaccca gaccttcccg tgcgaggcga ccacggccga
     8641 gatcggccgc gaactcgtcc gagacctcct cagtgtgtgg catctcgacg gcctcgccga
     8701 ccgtgccgcg ctgatcgtca cggagctgat cgcgaacgcc tccaggcaca ctccgtgtcc
     8761 cgaggtccgc ctcacggttg ggcggccgga cgcgacacga ctgcgtatcg ggatcgtcga
     8821 ccgggaagca tcgcgtctgc ccatactcag ccaggcggct gacgacgacg agtcgggccg
     8881 cggactgctc ctcgttgatg ctgtcgctga ccggtggggc tacgacctgc acggctcggg
     8941 cagacgcccc tggggcaaag aggtctgggc ggaacttcgc accgagggcg gcaagtgagc
     9001 atcccggcca cggcaccctc gccccttccg gatctcgccc gactccgacc ccgccagcag
     9061 atggccatgg actgtgccct ctacgcccgg ccgctgggag cgagcggtcg acggctgggc
     9121 gagatacgcc accggggcct gccgttccag ctctgggcct gcgctcccaa ctgccaggcc
     9181 gccagatcga ctatcccgac cagctgagaa aggggacgtc cttccatgga gcggccgtgg
     9241 atcaccggtg attgctggct cggctgcggg cgtacgggag tcctggtgat ctggctcggg
     9301 ccggtgcagt gggacgggca ccacgccccc ttctactcgt gcgagccgtg cctcgatcgc
     9361 ctcaaggccc aggcgcttgc ctacttcatg gagcgacgac cggcatccgc ttgatcggac
     9421 ttccggcaca tgacttcccg gcgtgaggca gacaccccgc gaggacttcc tacgcggagc
     9481 acgtcccctc gtggcgggcg gctaggagcc gtccggggag cagccatctg gcaacgctcc
     9541 cgtgatggca cctggtgggc gctccagccc agtaacacca caacgatcac aaggagttga
     9601 agcatgacgc gcagcaccgt agttcccagc cgcaccgaag tacgcccaca gatccccggg
     9661 gcgtcggacg gcttcgacct agacgtctcc ctcgtcgaga tcgccgaccc ggccggcctg
     9721 gtcaacctga ccgacgacaa ctgcgggtcc acctgcggcg cctgcaccac caacgtcgcc
     9781 tgacccggtc ccgagatcac cccggtctgg tgccgccgcg attccacgcg gcggcaccag
     9841 ccgcccggcc cttcacgtac ggaggtactc ggtggttgct ccgcccgcag cgttccgcac
     9901 cggtcccact gctctcgtcc gcgccgtggc atggccctcg ctgccgtttc ctccatgccc
     9961 tgaccttgat gaccgctcgc ccggtggttc gtctgcccgt gtggcgtggc tacgcgcggt
    10021 ttgggcggac caggacgtcg ccgaggcact ccagcactcc agcccggtcc tggccgcgca
    10081 ggtacgagcc ctgtgcacag ccgagcaccc cgccctccgg gatgtgcagc gcgcggcgct
    10141 gtccgtggcc cgctacctgc tgcgggccca gcgccgggcg acacccttcg gcctgttcgc
    10201 cggcgtggcc accgcggagt tcggcccgca cgcgagggcc gactggggtg aggagcacgt
    10261 ggccgtcggc cgcgcggggg cagagtggct ggcggccctg gtcgcacggt tggagtcatg
    10321 cccggacctc ctcgaacggc tgcccgtcgt catcaacaac accgtgacgt accggggaga
    10381 ccggctcatc gtgccgttcc agcccgacgt ccaggacgac cggacgcgcg cggtcgaggc
    10441 ttctctggct ttgaccggac cggtgcgcgc ggtccttgcc gcgacccgac tgccgatccg
    10501 gttcggcacc ctcgtggaca agctccaggc ggagttcccc gaggcaggtc ccgagaaggc
    10561 ggggcaattg ctgacggagc tgatccggcg gcgggtgctg atcacgggcc tgcacgctcc
    10621 gagcaccgag gtcgacgccc tcgggtatct gctcggccaa ctcgacgcga tcgacgccgg
    10681 acgcctcgcc ccggtcgcgg agaccgtacg cgaactccac gcggtccggg cgggcctgga
    10741 ggagtgcacc acgcgcggcg gccgggacag cgcagcggcg cggatgcgag acctcgtccc
    10801 cggcctgcgt cgtcacccca tcgcgctcga cctccgcctg gacgcgcgga tcgttctgcc
    10861 ggaagcggtc gcccgagaga tcgagcgcgc cgctctcatc ctgacccgct tgagcatccg
    10921 cccgtacggg accgccgcct ggaacgagta ccaccagcgg ttctacgagc ggtacggcat
    10981 cggcacgatg gtgccgctcg cggagaccgt ggcggacagc ggcaccggct atcccgacgg
    11041 ttacccaggc gctccggccg acgcacgcag gccccgcgtc tccgctcggg atgacgccct
    11101 cgtacggctg gctcaggccg ccgtgctcga cggccgcgac gaagtgatcc tcacggacga
    11161 acagattgag gccctggacg tgggtcccga cgagccgcgg ctgccgccgc acttggagat
    11221 cgtggtgcgg gtgcacgcgg ccagcctgga ggagttgcag cgcgggcggt tccggcttga
    11281 ggtcgtgagc gtgtcccgtg gcgccggcgt ctccacgggc cgattcctca gcgcgctggc
    11341 ccccgccgac cgcgaggccc tggtcacaga gcttgccgac ctcccggccg cagacggcaa
    11401 caccatgccc gcgcagctct ctttcccgcc cctgctctcc gagagcgccc acgtcacccg
    11461 ctccccacag gttctaccca ccgtgatcag ccttcaggag caccgcgccc cgcaggacac
    11521 catcctcacc ccgaaggact tggctgtggg gtgcgacggc cgccgcatgt acctcgccgt
    11581 ccccgagcga ggccaccgcg tcgaggccgt cgggatgcac tcgctgaacc tgcgcaccca
    11641 cactccgcca ctggtgcggt tcctcaccga actgtcccgc gcccagtgcg cgcaggtcac
    11701 catcttcgac tggggcgccg caacggcgat gccgttcctt ccacgtctgc ggtacggccg
    11761 catcgtgatg gccccggcac gctggcggct ggaagcgtcc gaactgcccg gccatgcccg
    11821 ccctcgggcc gagtgggacg ccgcgctcag cgactggcgt gcccggcgga ggcggccgcg
    11881 ccgcgtttac ctcgtagagg acgaccggcg cctcttcctc gacctcgacg aggccggcca
    11941 ccgtgcgctc ctgcgcagac acctcgaccg gacgcgcctg gccgtactcg tcgaggcccc
    12001 ggaaccagag gcgtacggct ggtgcggcgg gcgagcccac gaggtcgtgg tgccactcaa
    12061 agcaaccagg ccgtcgacat ggccgccact gccagctccc ggccgggccc gtgccctgtc
    12121 tgcggcccag atgcagacgc ctgcctcttc gtcggttctt ctggctgccc tctacggtga
    12181 cccccgccgc caagacgtct tgctcttccg gcacctgccc ggcctcctcg aacagctcgg
    12241 caacccgccg tggtggttca tccgcttccg cgacccggac caacacctcc gcgtacgcat
    12301 cgccctcccc gacccggaag ccttcgccga cacggcccga acggtgagcg cctgggccga
    12361 cgagctgcga agcatcggac tgatggccga cctgcgttat cccacctcct accgcgagat
    12421 gggccgctgg ggctccggca ccgcatggga ggcggccgag gaggtgttcc gggcggactc
    12481 gcgcgccgtc ctggcccagc tcgcgcagcc acagcgcccc ggactgcgca cgctggttgc
    12541 ggcccacacg gtcgccatcg cctctgcgtt cctcggcagc accgcagccg gtatgcggtg
    12601 gctgatcgac cacattccgc cgacagcccc caaaccggtt ccacgcccgc agttcaccga
    12661 ggccgtacgg ctcgccgacc cgagcgacga ctggtcagcc ctgcgtagcg tcccgggcgg
    12721 agacgccatc gtgtccggat gggccgaccg ggaagcggca ctcgccgcgt accggccgca
    12781 cctgcccggc ccggacaccc agggcatcgc cgtcgacgac gtcctgacct ccctgctgca
    12841 cgttcacttc gtgcgccacg tcgccgtgaa cttcccggag gaagaggtgt gcctctacct
    12901 cgcgcgtgcc gccgccctgg cctggaccgc ccgcaccagg gggagggctt cgtgaccgcc
    12961 taccccgcgc tcggcctggt cgacgccatc gccgctcagc tcgccgaccc cgacaccgtg
    13021 cccctcggct ccaggactct gtcctcggac cggcagcacc tcgcctacgg cccgcccgga
    13081 atcgcgctcc tgcacgtcga gctggccgcg aacggcctcg gcccgtggca ccgcgcccac
    13141 tactggctca ccgccgcctc ccggcagccg ctcaccagcg gctcggacag ccacccgttc
    13201 tacggagtgc ccgccttcgc ccacgccctg agctgtgccg ccgaccacct tcccggctcc
    13261 taccagcgcg ccctcgacgc gatggacgga cagatcgcag tcgacgtcgg acgccgtctc
    13321 gacgccgcgc accgccgcat cgacgccgga cgcctgccgc agctcgccga gttcgacgtc
    13381 atccggggcc tcactggata cggcgcctat ctactgcgcc gaaaccccgg cagctccacg
    13441 atgcgcgccg ttctcgacta ctgcgtgcgg ctcaccgaac cgatcaccca ccacggcgag
    13501 accctgccgg gctggtgggc ggagaccggg ccctcgggca gtccggacga ccgattccct
    13561 ggcgggcacg ccaacaccgg tatggcgcac ggcatcggcg gcgtgctcgc cctcctggcc
    13621 ctcgccgctc ggaacggctc cgtcatcgat ggccaccatg cagcattgcg caccatcctg
    13681 gcctggctgg accgttggaa ggagaaggcc gacggcgggc cggtctggcc gtactgggtc
    13741 actcagggcg agctgcgcag ggggggtctc gtcccctccg cgccccggcg gccctcctgg
    13801 tgctacggca ccgccggcct cgcccgcgcc cagcaacttg ccgcgctcgc cctcggcgat
    13861 accagccgcc agatcgacgc ggagaacgcg ctcgtggccg ccctcaccga cctcgaacag
    13921 ctgaagacca cgacggacaa cggcctctgc cacgggttcg ccggcctcgc ccacactgcc
    13981 acgcgtacgg ccgacgatgc ccacccctcg accgcgggaa gactccgcgc cgcgatcccg
    14041 gccctcctgg ctgcggtcac ccctccgggc accgaccccg aactcatggc cacggcgctc
    14101 atccaggacg agaaagacgg acccggcctg ctcgacggcg ccgccggcac agccctggcc
    14161 ctcctcgcgc ccagcaccgc agcaccaccc cagtccgcct gggacgcatg cctcctcatc
    14221 tcttgatcca ccgaccgaag gaccgctatg cctcccgacc gctggcagca gcacaacatc
    14281 accttcttcg accgcgagag tgcccggcgc accatcgccg aacgcgtcgg ccccgccctg
    14341 atccaggccg agaccgacgg gcagctcacc agctggtggt tcatgaacaa gcagccctgg
    14401 ccgttgcgtt acctcgccgg caagccctca ccagcaattg agtcgctcct gagcgatctc
    14461 atcggcgacg gcgtggccgt gtcgtgtctg cccggcatct acgagcccga gaccgacacg
    14521 ttcggcggac ccgaggccat ggatgcagcc cacgaactgt tccacagcga ctcccgtcac
    14581 ctgctcacct accagccgaa cccgatgcac ttgggacgtc gggagagcgc cgtcctgctg
    14641 gcgagcgtca tgatgcgcgg tgctggactc gactggttcg aacagggtga cgtatgggcg
    14701 aaggtcgcag ctcttcgacc ggccaccgct ccacaaccac ccgaacgagc cgccgaactg
    14761 actccggcca tgcggaagct catgaccgct gacgcctaca gcgtctgccg cctgggcggc
    14821 ccactccacg ctcaccagga atgggtgacc gccttcgaac aggccggcgc cacgctcgcc
    14881 gaactcgcag gctgcggcgc cctcacccgt ggcctgcgtg ccgtcattgc ccaccacgtg
    14941 atcttccacg ccaaccgcgc cggtctcctc cgggacgacc agagcgccct gtcccacatc
    15001 gcacgagagg tagtcatggg aacgagtgac cacaccgagt cgcccaccga ggcaacggcc
    15061 gacatcgata gcgtcggcgc ggtgaacacc gacacgatca ccacccctac agcgggcgcc
    15121 gagcgcctcc gcaacgccct ggtcgaacag ctccgcgcgg acgggcacgc ccgcacgccc
    15181 gccgtcgaag ccgcgttgcg gaccgtgccc cgccacgtgt tcgtgcccga ggcgtccctc
    15241 gaagacgcct acgccaacgc accggtgcac atcaagtacg acaccgacgg cacgtccatc
    15301 tcctgcgcct cccaaccggg cgtcgtcgcc ctcatgctgg accagctgga cgcccagccc
    15361 ggcgagcgca tcctcgaact cggtgccggc accggctaca acgccggtct gctcgcccac
    15421 ctggtcggcg agaacggaca cgtgaccacc ctcgacgttg acgacgacct cgtggagggt
    15481 gcccgcacgc acttcgccgc cgccgggatc accaacgtcg aggccgtgac ccgcgacggg
    15541 gcgctcggct acgccgaagg agcgccgtac gaccggatca tcgccaccgt cggcgcgcac
    15601 ggcgtaccgc acgcctggct gcagcagctc gcacccggcg gccggctcct cgtcccccag
    15661 cgcctcaagg gcaccgtctc ccgctccatc gcctatgagc agcgcgacgg ccgatgggcg
    15721 tccctcggca gcgagatgaa caccttcatg ccgcttcggc ggggcatcgc tgacgacgac
    15781 cgccgagtga tcccgctcag cacggacggc gccgtacgac tccaggcccc cgccgggctc
    15841 agcatcgacg ccgacgccct cgcaggtgta cttgaccagc cgcgcaccga ggagtggacc
    15901 ggcatgacgg tccgcgccat ggagtcgccg gagtggatgg aactgttcgt cacctgctcc
    15961 ctgccctccg gtctgatccg gatgctgttc ccccagagtg ccaagggcac tctgctcacg
    16021 gaggacccgt acccctcgtc gaccgcggtc gtcgacaagg gttccgtcac ctacctcgcc
    16081 cggcgcgtga gcaaggagaa gacccccgag ggcggcaagc tctgggagtt cggcgtcatc
    16141 ggccacggcc ccggcagcga cgagctggcc gcgaaggtcg ccgactccat ccgcacctgg
    16201 gatcgcgact accgcgaccg cgaggccacg ttcaaaatcc agcctctcga cgcccccgag
    16261 atcgagcagc gccccggtct cttcgccctc gacaccccgc tgaaccgcat cgtcgtcgac
    16321 tggcgatgac gccccacgcg tagcggacgg cgcccgtcgg cacacggctt gcgggcaccg
    16381 tcgcttcagc agtcctcact ctcgaccccg ggggatccat ggacccgcac ggccccatag
    16441 cccagcgctt cccgctcgtc gcacgattcc gccccgcctg cctgcccctg cctgcacgcg
    16501 taagggcact cgtcgatctg gccgacactg cggtggaaca gaccgaccag gggctcgcat
    16561 cggccgtcta caaccaggcc gcgctcatcg cctccgacct cgacctcccc gacctcgccc
    16621 gcgagatgtg ccaccagcac gccgccgcct acctccacgc ctgccccctc cccggcatga
    16681 gcgcgatccg aggactggaa ccggtcgtca acctggcccg cctccagatc cgcgccggcc
    16741 gcgcagatga ggggcgtcag cgactgctcg acctgcacaa ggccgttgag gccggaacaa
    16801 ccgtccggtt cgagggcatc aacgtacctg cggacctgac tgcgaccggg gaagaccgcc
    16861 aggaggttcg cgcatggctg tggcgtgtcc tcctcgcaga cggcacgcgc accctcacca
    16921 ccgaggggcg atgggccgag gcgctgacgc acatcgaagc ccaccatggc atcggaaagc
    16981 ggatgctcga cggtcggcag gtcgccgtgc tcgccgccct cgctgcgggt gacaccgcgt
    17041 gggcatctga cctccttgcc gacacgatgc ccggcgatcc gtgggagcaa gccgtcacgg
    17101 catgcctgac cgttctatgc cgccgcgacg ccgggcagcc gatcgacggc catctggcgg
    17161 acgtggtgac ggcctacctc ggacggaaga ccgaacctgg gatgaccgtc ttcgataccc
    17221 ggctcggact aacggtcctc gacgcgatcg gttccgccga ggcgctcgcc gcgcaccgca
    17281 tcgtcgagga tctccaccgc aggacgacgg acgccgaaga cggctacgcg gcccgcgaga
    17341 acttggccca tcctctgttc accgagatcg ccacggaccg gcaagtgcag gactgtcgcg
    17401 cgctggtgcg cgcctgcgcc ctcggcgctg gaaccctccc ggacgagctg cgaggagaac
    17461 tgacggcggc tctgcaagcc agcgatagcg tgatccggga aagcgtcgtg cgttcctccg
    17521 atctcgaagg aacgcaaccc ctgcggttct gacggtgtcg accatcgacc ccgcccgcga
    17581 ctaccagccc cagcacccca ccaacacgac gaaacccccg aacccgtagg ttcgagggtt
    17641 tccgatgtct tgagacatca caccgtagcg gggacaggat ttgaacctgc gacctctggg
    17701 ttatgagccc agcgagctac cgagctgctc caccccgcgt cgttggaccc gactctacgc
    17761 ggtgcgggcc cctgggcaaa atcggtgacg cggcccgcac cggcccggtc ctccgccggt
    17821 gcgggccgcg gtcgtcagga cgtaccgctg ccgccgcttc tgcgggactt gcgcagccgg
    17881 cgccgctcct tctcggagag acctccccag acgccgaacc gctcgtcgtt ctccagggcg
    17941 tactccaggc actccacccg ttcctcacac gcccggcaga cctgcttggc ctcccgggtg
    18001 gagccgccgg ggaccggaaa gaagaagtcg ggcccggtct gcgcgcacag cgcgcgctcc
    18061 cgccagccgg aagcgtgctc cgccggcccg atgaactcga tcaacatgca ggtcatgctg
    18121 gtgcgggcgg atcaacgttc gctgaacgag aggtcaacgc gcccgcgccc ggctcctgtt
    18181 ggcgcggcgc cctgcccggc tcaccgaccc gcgtgggagg ttaccggccc ggacacggcg
    18241 ctccgcgccg gtgcgccgcc tcggcgcgtc ggcccgcgcg ccgccccggg gccgggtcag
    18301 gccgactccc ggcgcaccag ctcggtctgc agcaggatgg acggcggcag gcccgcctcg
    18361 ccggagagct gggcgagcag gcgccaggtc atggtgcggc cgaactcctc gatcggctgc
    18421 cggacggtgg tgagcggggg cgaggcggtg gccgcgatgt cgagattgtc gaagccgacg
    18481 accgcgacgt cctccgggac gcgccgcccc gcggcctgca gcgtctgcag ggcgccgacg
    18541 gccatcaggt ccgaggccgc gaagaccgcg tcgaggtccg ggtgggactg aaggagccgg
    18601 cgcatcgcgg ccgcgccgcc ctcgaccgtg aagtcgccgt gcgcgaccgc gtcggtggcg
    18661 aagcccgtgc cggccatgcc gcggcgccag ccgctgagcc ggtccatgcc gaccgccatg
    18721 tcggccggac cggcgatggt ggccaccctg gtccgtccgg tgtcgatgag gtgacgggcc
    18781 gccaggcagg cgccgttgaa gttgtccacg tcgacgtacg gggcgtcgac cctcaccagc
    18841 ggccggcccc cgaggaccac gggcaggccc gcctcgacca gcaggctggg cagcgggtcc
    18901 tcgccgtgca ggctgacgac gagcgcgccg tcgacgtggc cgccgcagag gtagcgggcg
    18961 aagccgtcct cgtcctgctc gttggtcatc agcagcacca gctggagctg gctgccggag
    19021 aggccgctgt agatgccgcg cagtacccgg gcgaagaagg ggtcgctgag cacgaagttg
    19081 ccgggctcgg acatcacgag ggcgatggag cccgttctcc tggtcgccag ggaccgggcg
    19141 acctggttgg cgcggtagcc caggacctcg accgcgtggg ccacctgctc ccgggccttc
    19201 tcgctgacgt agggcaggcc gttgatcgcc cgggaagccg tggcacggga gaccccggcg
    19261 gccctggcga cctgttcgag agtggggctc gtgctcgggc ccggccgtcc cagaggctgc
    19321 gcccctgctg attcagtcac cggctctccg cgtgtggcag tgtcgcgcgc cgcgcgcggc
    19381 ggtccgcgcc ggggacggcg gcccgggcgg cgcgcccggt gcggcccgcg gggtccgcgg
    19441 ggtgcgggat tccgcggctc cgccgcgcgg gggcgggccg tcgggcgtcg ccgcgaaccc
    19501 gcggcaggcc gcggccggcc atgccggttc gctgcttcgt gctggacact cccccacccc
    19561 cactgacgcc gtccgattcc ggtgaccgcc gggcgacgcc tcgccggcag cgcactggaa
    19621 gcgctttcag actacccacg gaacaggagg accgccaggg aagggagggc tcccccggtc
    19681 cgccggccgc gcggggcggc cggctccggg aagccgccgt gcgcgccgcg gcctcccggg
    19741 ccccgcacgt cacgcggggt ccgggagcac ggcggagggt gccgtccgcg gatccgtcca
    19801 cgggtcatgg gtcagcagcc gatcggcgcg gtgccgaccg cgatgtcgtc gtaccagagg
    19861 gtgtcggcgc cgttgccgta gctctcccag ccgagccgca ggtcggtgag ggaggggcgc
    19921 cagtcgggct tgttgagcca ctgccggtcg atgtcgtggg tgggcgtgcc gtcgatgacg
    19981 aggccctcga cgaccgagcc gttcaccctg gtctccaggg tggagccctc gatgccgaac
    20041 tcgacgcagg tccattcgtt cacgggcagc ggcatgctct tggacacccc gaccgggctc
    20101 tgctccggca gggtcgcgtc gtcggactcg cggttccact gcagggcgcc gttctgaccg
    20161 cccatccgca ggtccttgcc gccgtcgttc gcgtccttca gggccgcgaa cgtcacatgg
    20221 gcggcgggca gcgcggtggt gtgccggacc cagaagcgga cgtgcagcga ggagctcccg
    20281 gccacctcgt ccagcggggt cgaggcgaac atgtggttgc agtagccctc cccgccgtcg
    20341 atccggagcg acttgctccc ggtgtgcgcg gtgccggagt cgaccgtcgc ggtgccggtg
    20401 ccggtgcagt tggcggcccc ggcggtccag cggccggagg gagcggtacc ggtctgcgac
    20461 tcgaagtcct cgcagaagcc ggaggcgtcg caggcggccg cgggccggtc acctgcggac
    20521 gggcccgcgg cggaggcgct gcccgtggcg ccggcggcgg tgagcgccag gacggtcgcc
    20581 gacgcggcca ggatctgccg gcggcgggtg gggcgcgcgc tccgcggcgg tgcggagccg
    20641 gcgggcgggg gtacggggga gtccggcagg ccgggtgacg aggacgagcg tgaagtcgta
    20701 ggtgaggaca tgggtcccga ccctcctcgg tgaaaggtga ggtggcggcg gagagatcag
    20761 cgccgcggtg ggggcctccc caggccccca ccgcgacggg cggtgattca tccaccgcgg
    20821 ggcgggcgcg cgcggatccg ctggacgccg cggcgcgcgg gaggaacgca ttgccgccgg
    20881 cgtcgacgcg cccgtgtggt gtgtggcggc cgggccccgg agggccggcc gggtggccgc
    20941 ggcgggccgg gccggagccc ggtccgccgc gtccggatca tccgaacagg gcgtcgtgcg
    21001 cggcgaacgc cgtggcgatc tccgtctggg cccagtagcg gtggtacgtg aactccggcg
    21061 cggagccgcc gttcaggtac tgctgcacct tcgggaagtc ggggtcgctc tcgtagaagg
    21121 agcggatcga caggaaggtg gagtccgagt tgatctcgtc accgttgggc atggtgcccg
    21181 tccagccgtt ggggatgtag agcttgtcct caccggaggt gacctcgaac cggtcgtagt
    21241 ccttgcggac ctcggggatc gcgatgccca ggtcgtcctt gtgggcgagc atcccgtcga
    21301 gcaggccctc gccggcttcc ctggcctccg cgtcgcccga gccggccgcg tagtacagca
    21361 gggtcttggc gaacgaggcc gcgacaccga cgtcgttggt gtggttcagg acctcgacgt
    21421 gcagaccgct gttgctgccc gggttggagg cgttccaggt gtcgggctgg ccgctccact
    21481 ccaggtcgga cgggatctgg tagttgcccg tgccgtcgat cgtggagttc tccagggccc
    21541 agtcgaccca cttgtccatg atcttcccgg cgcgctcgtc accggtctcg gcgtacagct
    21601 cggcggtgcg ctgcaggccc cagacctgga agccgaacca ccggttcgac ggcgggtcgt
    21661 gccagacggg ctgccagtcg tagtacatgc cgtagaaggt ggaggcgttc gacggcgggc
    21721 tggcgtactg gccgtcccag ctgttggtgg caccacccgc gatgccgccc tcggaggact
    21781 gcagccactg caggaactcc agctgccggt ccaggctctt ggcccagtcg gcctggcccg
    21841 aggaggactt cggcttcatg tccgggtcct cggccagggc gtaggcggcc atcgggttct
    21901 ggtagccctg gtgggccgcg ccgtcaccga tgcgccaggc ccacgggtac tgggcgtcct
    21961 ggttggcgcc gccccaggcg tagtaccagg acatcaggta gtgcgcgctg tccttgccgc
    22021 tgcccgcggg gcaggagggg ctggtgcagt tgccgatctt cttgaagtac ttgtcgaaca
    22081 tggcgtagcg caggtagtcg cccatcttga ccgcgttgtc gaccacgtcg gcgacctcgc
    22141 cgcccttgcc ctgctcctcg gcgtacttct tggcctggta ggccacctgc accgcacgcg
    22201 cgtcggcgtc cggggcgttg gtgtacttcc actgcttggc gtactcggcg tcgtcggtga
    22261 acaggtcgag gaacccgttc tcaccgccgt gggcgaaggt gtcgcaggac ggctgcgtca
    22321 ccgtctccca gacggactcc tgcgagccgc gctggaaggt gttgatgaac gcgggcgccg
    22381 tctcgccgtc accgcagaag ccgaagccgt acgtgttgtc cacgtccagc agccagtgca
    22441 tgccgtagat ctcgtcggtc ccgtaggccg acttgagctc gccggcgatg gggtcctggc
    22501 cgaccgaaac cccggagtcg agcttcgccg ggtactcggt cgggctcggg tgctcgggcg
    22561 cgtaggtggc cggggagctg gcgtcgtagg cgccgttggt cggctggtcc tcggtgcccg
    22621 ggatggcgaa ctcctccagc gacgcccagg cgtcgttgaa cgggccccag tcctcggtga
    22681 tccggccgta ctccgactcc agccacaggt agtagctgaa cgcctcggac gtggtctcgt
    22741 ggccgtggtc cggcgcctcg acgatcagcg tctcgatggc gtggtacggc accttcagcc
    22801 cgttgaaggt gcggtagtag ccgctcgacg ggtcgttgat cttgttgtac aggtcgagga
    22861 agtcctgctg gtactccgag gcctgcggcg agatctcctg gaccggtacg gtgccggcgt
    22921 cgtggcccgc ggcggtcgcc ttgaagacgg ccttggccag gtcaccggtg gtgtccgcgg
    22981 agttgacggg cacctgctgg acgcggtccc agttctcggg ggtgaacgtc agctccgact
    23041 tggccgcgct gatgtccttg gtgccggagg cgcgctccag ggtcacccgc acgtccgagg
    23101 acggcttggc ggacagcttg atgccgacgg tcgtctcccc gccctgcttc acctgccgcg
    23161 cgacgggaga ggcgatcacg gccggcttct ccaggacgtt gaccagggac gggtgcgagc
    23221 cggccggctt gccgtccttg tcgtacgcct tggcagtgat ggagtactgg ccctcggggg
    23281 cattcttcca ctcgccctcg aacggggcct tggagtcggt ggccagcagc ttgctgtccg
    23341 cgtagaactc gaccttggcg acgtccccgg tggtcttcgc cttcagcggc acgccctcgg
    23401 gggccagcgc gtagttgtcc gcgcccgtct ccgaggaggt gagagcgacg ccgatggcct
    23461 gggcctcggc ggatccggcg gcctcggagg cgaaggtcgt ccccggcacc acccccgcga
    23521 cgagagcggc gagggcgagt cctcccgtga ccgggccggg ccgtagcctg cgccgtaggt
    23581 gtgatctcat tgcctgctgg ttcctctctg tcacatggtg tggggccata tgtgtggggc
    23641 atggaggggt ggtgctgtcc ggcgtggacg ggcgcgcccg gtcggggtgt gcgcgtcaca
    23701 cggtggatcc ggccccgtga gtgggctgtg cggtgcggtg cggccactca cggggccggt
    23761 gatcgtgggg gcggaacggc ccgggcaccg tggggtcggg acggcgcggg cgggccggac
    23821 gggtgggggt gtgcggctcg ggtccgcggt tcctcgtacc gtgccgtcgt caacggcttc
    23881 ccgggagcct tacgcgggtg gggggtggtc agctctcggc acggtggact gaaaccgctt
    23941 ccagtgccgg gactgtagcg gtcacgccgg gctctgaaaa cccttactcg tcagtccagt
    24001 tggacaaagt aagcggctgt gttcggcacc atgccattca ccagcgcttt tgttgacacg
    24061 gcggcggatg aatcgccgcg agagccgaag tctcttcaac tcgcctctct gacctgcggg
    24121 ttggcaagtg gttcggaccg ctcctattga cagggctacc ggccgcgctc actctaagag
    24181 cgctcccagg tcctgaccga cggagccgat caccggccgg ccaccgcgca ccccgtcgtc
    24241 ggcgcgagcc cagtgatcgt cccggcacgg cggcccggga cggacggaag cgactgccct
    24301 gacccggcct ccgtccggcc gaccgcacac cggccgccgt gccaccgcac ctccccgcac
    24361 cgcgagctcc gcccccaccc gcaccgcccg ccgcaccccg caaacagcac cccgccgcac
    24421 cacccgcaag cagcaccccc acccgtaccg ccccaccgcg agcacggagg cttgcagatg
    24481 aaccccatcc gacagcggac gggggacgga ccgccgcgcc ggcggccctc gccccccgtc
    24541 gcgctgacgg ctgccgcgcc ggcccggacc gccgccgggc cggccggcgc ggggcgccgc
    24601 cgcggcgggg aatcgccgcc acggtcctcc cggccgcgcc ggggaatccc cgtgcggcgg
    24661 gaaccgtcca ccccgaactc cggcacggcc gacccccgcc cggtccgtgc cggaacgggc
    24721 ggccgggcgg cgcgcacccc ggccctccgc ggccggacgc cggtcaccgt cccggcgggt
    24781 gccgcgccgc ccgcgccgtc caccccgcgg ccgccggcct cccagccgcg gccgccgcac
    24841 acccccgccc cgaccaccgc cccctccgcg gaccggcccc gcacccggcc cgtgtccggc
    24901 gccccgcgcc gccacccccg tccgccggac aggcgccgga ccccccggcc cctcaccctc
    24961 cggcccccgc atcccccggg aggactccac cgacgccagc tcccgcagcc cacgtcccgc
    25021 ccctgacgtg cccggaagcg ctccagaact ccctcctgga agcgcttcca cctctccggg
    25081 ccccgggccg ggaccgcttt ccaccccacc ccccatggag cttcacccat gaagaaatcc
    25141 tcctgtgcgg cggccggtgc ggccaccctg gccgtcgccg ccttcctgat accggccccc
    25201 gccggcgcct ccgaggccgg gccggcggcc gacagcacgt actacgtgga ccccgagacc
    25261 cagtccgcca agtgggtcgc cgcgaacccc ggtgactcac gggcggcggt gatccgggac
    25321 cggatcgcct ccgtggcaca gggccgctgg ttcaccacga ccaacaccgg cgaggtccgt
    25381 gccgaggtcg acgccttcgt cggcgacgcc cagagcgccg ggcagatccc gatcatggtc
    25441 gtctacaaca tgcccaaccg cgactgcggc ggggcgagca gcggcggagc cgccaaccac
    25501 tccgcatacc ggcagtgggt cgacgagatc gccgccggcc tgaacgggcg tcccgccgcg
    25561 atcatcatcg aacccgatgt gctggcgctg atgtccaact gccaggacgc ctcgcagcag
    25621 caggccaccc aggagtcgat ggcctacgcg ggcaaggcgc tcaaggccgg ctccgcggag
    25681 gccaaggtgt acttcgacgc cggccactcc cgctggcact ccccgcagga gatggcctcc
    25741 cggctggccg cctcggacat cgtgaacagc gccgacggca tctccaacaa tgtgtcgaac
    25801 tacaaccaca cggccgacga ggtcgcctac agccaggccg ttctcaacgc catcggctcg
    25861 aacgagctga ccgccgtggt cgacaccagc cgcaacggca acggcccgga cgcccggggc
    25921 gaatggtgcg acccgcccgg ccgggcgatc ggcaccccca ccaccgccga caccggccag
    25981 gaccggatcg acgcctatct gtgggtcaag ctccccggtg aggcggacgg ctgtgccgcc
    26041 gcggccgggc agttcgtgcc gcagctcgcc tacgacatgg ccaacgcggc gcccgccgct
    26101 tccacccctt cttcttccag aaccgcttcc gaggacggtg cacgatgagt gaatcccgag
    26161 tcagccccgt gacggtcgcg ccgggcggga gaggactgac cggtgcgctg gaccgcagca
    26221 gcggccatgt gctgggcctt ttccggatcg tcgtcggctt cctcttcgcc tgccacggcg
    26281 ccgcgaccct cttcaacatc ctcggcggtc cgcacggcgg cgtggtacc
//
