LOCUS       NZ_CP023202            27055 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1013145
            Orig. end                         :: 1040200
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27055
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..27055
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27055
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:17055](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17055)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    8..22
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.07"
                     /tool="antismash"
     misc_feature    complement(173..187)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.9"
                     /tool="antismash"
     misc_feature    2189..2204
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.63"
                     /tool="antismash"
     misc_feature    2190..2203
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.36"
                     /tool="antismash"
     gene            complement(2435..2746)
                     /locus_tag="SXIN_RS04365"
     CDS             complement(2435..2746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001019.1"
                     /locus_tag="SXIN_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypco2 family protein"
                     /protein_id="WP_019706385.1"
                     /transl_table=11
                     /translation="MIELSEMIRELRRELTSAMADGEGRALRFEAGPVEVETAVEVGRE
                     AGGSGRVRFWVVEAGAEGRLTRAATQRITVTLQPVRTDEDGRPAGPALIAGDEADGER"
     misc_feature    2722..2736
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(2798..4021)
                     /locus_tag="SXIN_RS04370"
     CDS             complement(2798..4021)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922331.1"
                     /locus_tag="SXIN_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_192883658.1"
                     /transl_table=11
                     /translation="MRSLAARLRPAAFGADPAGERLERIRRSPQWADGQFRNPVPTRMM
                     LPGSGRALLRAQFDREARRRRAPAGAIPVHRPAAETRNAPPPSGLRLTWMGHSSVLAEI
                     DGHRVLFDPVWSERCSPFAFAGPRRLHPVPLPLDDLAPVDVVVISHDHYDHLDMAAVRA
                     LAATGTRFAVPLGVGADLEHWGVDPARVDELDWHESARVGELTLTATPARHFCGRGLVR
                     GMRTLWASWVVAGPEHRVFHSGDTGYYHGFAETGAAYGPFDATMIQIGAYSEHWPEIHM
                     TPEEGVRTHLDLSGGTPAGALLPIHWGTFNLAPHPWEEPAERTAAAAREAGVRLAAPRP
                     GEPFEPGGDGPLPGEPWWRAVAVPAAAGERTADGDRAAAPGAAGPAAGGATEAAHRPYS
                     SGPARGGQ"
     gene            complement(4411..5250)
                     /locus_tag="SXIN_RS04375"
     CDS             complement(4411..5250)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145659.1"
                     /locus_tag="SXIN_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_019710751.1"
                     /transl_table=11
                     /translation="METGVTDQGFPVEHIDTSRPHPARMYDYYLGGWDNYEVDRAAAED
                     VMKLAPDTRATARANRAFMQRAVRTVVKAGVRQIIDIGTGIPTSPNTHEIAREIAPDTR
                     VAFVDNDVIVAAHAEAKLTNEGNAAFVHADVREPRTIRDHPTIRRLIDFDQPVALMLVA
                     VLHFIDDASDPEGILAALGEDLPAGSHLILSHVTADFHGESRRRAEGEDVVKVYDRTTA
                     HLTLRDHARILPFFNGYELLDPGLVQATAWRPEEGTGKAGEAGGRTVACYGGVGRKP"
     gene            complement(5334..5579)
                     /locus_tag="SXIN_RS04380"
     CDS             complement(5334..5579)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602002.1"
                     /locus_tag="SXIN_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_019710752.1"
                     /transl_table=11
                     /translation="MDRRKRIYNGMPSTELGTEGWHKPWSGGNGGSCVEAMKLGDGRVA
                     LRQSTDPDGPALIYSHHEIATFIRGAKDGEADFLLA"
     misc_feature    5554..5570
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     gene            complement(5583..6449)
                     /locus_tag="SXIN_RS04385"
     CDS             complement(5583..6449)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713862.1"
                     /locus_tag="SXIN_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_019710753.1"
                     /transl_table=11
                     /translation="MKDARSGGAPTVLRLVLGKRLQDLRERAGLSFAEAGRALDVTHAT
                     VRRMEKAEVGLKIPYVEKLLRVYGVTDQRDIDAFVSLAREANQPGWWHRYRDVLPEWFS
                     AFVALEGEASVIRAYEPHYVPGLLQTEAYARAVLRAGMPHAPQAEVERLAALRAERQSL
                     LTKDDPPLLWVVMDETVLRRPIGGPEVMRAQIDRLIEATEMPRVRLQLMPFSAGPHPAM
                     YGPFHIFRFPLPELPDVVYSESLVGAVYVDQRDDVSAFLEALDRMCAQAAPAHTTRTVL
                     GGIRKEI"
     misc_feature    6526..6535
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     misc_feature    6530..6546
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.13"
                     /tool="antismash"
     misc_feature    complement(6534..6548)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.33"
                     /tool="antismash"
     gene            6587..7051
                     /locus_tag="SXIN_RS04390"
     CDS             6587..7051
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056078.1"
                     /locus_tag="SXIN_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_019710754.1"
                     /transl_table=11
                     /translation="MAPSHEALRLSRCGGVVARHLEDVFHLPAMSASVCKARRRVLTLL
                     SEWGVDERCRADAELVVSELFTNAVRHTDSVKVTCEIRLTGQRLRLEVTDQGCAETEPR
                     ARFSGIDEEGGRGLMLVGALAEEWGVRPDETGRGQVVWACLRRSGRTAAL"
     gene            7362..8177
                     /locus_tag="SXIN_RS04395"
     CDS             7362..8177
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994393.1"
                     /locus_tag="SXIN_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_019710755.1"
                     /transl_table=11
                     /translation="MTQTPQVPQAEQTEPRLSGVRNFRDVGGLPTGDGRTVRRGVLYRS
                     GHLAKATAADAAFLSSLGLHTVFDFRNDADVALDGHDIALDGVRHVNIPLTDPADGAEF
                     WRMVRDGDLTQLRAALGDGKAALRMSSTYRVIMKTRTTEHSRVLHALAEDSVPALMHCA
                     AGKDRAGLSVAVTLLALGVERDAIEEDYLASAAPHRRYRFRRSDDSPAALTPEVEDLLS
                     PLFDARREYLDAAFTTIEEEWGTVDAYLTRGLGFGPDRRERLRARMLDG"
     gene            complement(8326..9336)
                     /gene="hpnH"
                     /locus_tag="SXIN_RS04400"
     CDS             complement(8326..9336)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386169.1"
                     /locus_tag="SXIN_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_019710756.1"
                     /sec_met_domain="PF04055 (E-value: 6.3e-17, bitscore: 60.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.2e-08, bitscore: 31.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIRVGTYLFAQKLRRREKFPLIVELEPLFACNLKCEGC
                     GKIQHPAGVLRQRMPVAQAVGAVLESGAPMVSVAGGEPLMHPQIDEIVRQLTARRKYVF
                     LCTNAVLLRKNIEKFEPSRYFAFAVHIDGLRERHDASVAKEGVFDEAVEAIKEAKRRGF
                     RVTTNSTFFNTDTPQTIIEVLDYLNDELLVDEMMISPAYAYEKAPDQEHFLGVAQTREL
                     FAKAFAGGNRRRWRLNHSPLFLDFLEGRVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEETDWDAYGRGRDPRCANCMAHCGYEPTAVLATLGSLRQSLRALRETAG"
     gene            complement(9342..10001)
                     /locus_tag="SXIN_RS04405"
     CDS             complement(9342..10001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100142.1"
                     /locus_tag="SXIN_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_095756606.1"
                     /transl_table=11
                     /translation="MAEDGGPATLLIACALSIERLALRGGDRTGAPRALTVLRTGMGPR
                     SAERAVLRGLRRADPYAVGTPVLATGFCAALAPGMRPGDLVVAAETRDRIGRVPCAGTA
                     ALAGALAGRAGRARSGTAVHTGPLAGTDHLVRGAERARLHATGAIAADMESAAVLRTAL
                     AAGPRPVAAVRVVVDTPERELARGGTVLGGISAFRVLRTVLPAFYEWHRSLPLPRR"
     gene            complement(10001..12088)
                     /gene="shc"
                     /locus_tag="SXIN_RS04410"
     CDS             complement(10001..12088)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358581.1"
                     /locus_tag="SXIN_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_095756607.1"
                     /sec_met_domain="T2TS (E-value: 1.9e-151, bitscore: 503.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSSGPRPPALPAGGPPGPLPAPPAAPAGESAGPRRESGT
                     PDPRPPAPGPRDTPAAAERAAARAVRNLLGRQHDEGWWKGDLETNVTMDAEDLLLREFL
                     GIGDRRTTEAAARFIRSRQCPDGTWATFHGGPGDLSATIEAYVALRLAGDAPADPHMAA
                     ASAWVREHGGIAASRVFTRIWLALFGWWPWEQLPELPPEMIYLPKWFPLNIYDFGCWAR
                     QTIVPLTVVSALRPVRPAPFPLGELHPDPAAPRRAAATATGWDRVFRRLDRLLHAYRRV
                     APPPLRRAALRACARWIVERQENDGCWGGIQPPAVYSVIALHLLGYDLDHPVLRAGLDS
                     LDRFAVWQDAPGPGGGPSRMIEACQSPVWDTCLATIALTDAGLPAGHPALVRAADWMLG
                     EQVLRPGDWSVRRPGLPPGGWAFEFHNDNYPDTDDTAEVVLALRRTAHPEPERVDRAVR
                     RAVRWTLGMQSADGAWGAFDADNTSAFPNRLPFCDFGEVIDPPSADVTAHVVEMLAAEG
                     LAADPRVRRAVAWLLAEQEPSGAWFGRWGVNYLYGTGSAVPALVAAGVPAEHPAIRRAV
                     DWLSSVQNEDGGWGEDLRSYPDPEWIARGESTASQTGWALLALLAAGEEDGKAVERGIG
                     WLARTQREDGSWDEPQFTGTGFPWDFSINYHLYRLVFPLTALGRYLTAVGRQPRTVPRD
                     A"
     gene            complement(12296..13354)
                     /locus_tag="SXIN_RS04415"
     CDS             complement(12296..13354)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088376.1"
                     /locus_tag="SXIN_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_238153671.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-57, bitscore:
                     193.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTAQPAIDTADVPALLLRGRTLATPVLRAAVARLAPPMDTVAAY
                     HFGWIDAEGRPAEGDGGKAVRPALALLSAEAAGAAPETGVPGAVAVELVHNFSLLHDDL
                     MDGDEQRRHRDTVWKVHGPALAVLVGDALFALAGEILLEMGTPEAARAARRLTTATRKL
                     IDGQAQDISYEHRERVTVEECLRMEGNKTGALLACATSIGAVLGGADDHLADSLESYGH
                     HLGLAFQAVDDLLGIWGDPEATGKQTWSDLRQRKKSLPVVAALAAGGAASDRLAAILAV
                     DAKSDRTEDFDETEFAERAALIEEAGGRTWTSQEAQRQHTAAIGALDRVDLDPHVREQL
                     VALADFVVVRRK"
     gene            complement(13656..15161)
                     /gene="hpnE"
                     /locus_tag="SXIN_RS04420"
     CDS             complement(13656..15161)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056066.1"
                     /locus_tag="SXIN_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_095756609.1"
                     /sec_met_domain="DAO (E-value: 5e-08, bitscore: 31.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPPVPEPSPPRPGPAAPAGGPGPYRAAGRTAVVVGGGIAGTAAA
                     LALADAGVRVTLTEARPRLGGLAFSFRRSSPAGDLTADNGQHVHLRCCTAYRALLERVG
                     AAGLAPVQHRLDVPVLDAARNRAGRLRRSALPVPLHLAGSLARYPHLSPAERAAAARAA
                     LALRRLDPADPALDGTDFGGWLRRQGQSPRAVEALWDLIGVATLNAPADRASLALAAMV
                     FRTGLLSAPGAADIGRARVPLGELHDTRTRRALEGAGVRVLLRTRARALHRRGAGSGGW
                     RVAVTAPGGPETLRADTVVLAVPHDEAHRLLPDGALDDPGRLLDIGTAPILNVHVVYDR
                     RVLRRPFLAALGSPVQWVFDRTEPSGLTGGAQYLALSQSAAGDIIDLPVAELRRRFLPE
                     LERLLPGARNARVADFFVTRERAATFDPAPGTGRLRPPARTRVPGLQLAGAWTATGWPA
                     TMEGAARSGATAAAAALRHLRTVRTHPDPPPGPGRVDPQQEAA"
     gene            complement(15161..16162)
                     /gene="hpnD"
                     /locus_tag="SXIN_RS04425"
     CDS             complement(15161..16162)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031162.1"
                     /locus_tag="SXIN_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_238153672.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.1e-55, bitscore:
                     187.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.2e-68,
                     bitscore: 228.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTVTPSASAPASASVPAPVLAAYRYCETVTGHQARNFAYGIRL
                     LPPGKRQAMSALYAFSRRVDDIGDGDLPASAKLARLDDTRALLARVRDGGVRTDDTDPV
                     AVALAHAAERFPIPLAALDELIDGVLMDVRGETYDTWDDLRTYCRRVAGTIGRLSLGVF
                     GVTSPHGHGARETERAPEYADTLGLALQLTNILRDIREDAAHGRLYLPADDLAKFGCAA
                     GFHTPVPPAGADFTGLVHYQARRARALFTEGFRLLPLLDRRSGACVAAMAGIYRRLLDR
                     IARDPEAVLHGRVSLPAPEKAYVAVRGLSGLDARHITRRTARHRAGRAGGRA"
     gene            complement(16159..17055)
                     /gene="hpnC"
                     /locus_tag="SXIN_RS04430"
     CDS             complement(16159..17055)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004951782.1"
                     /locus_tag="SXIN_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene synthase HpnC"
                     /protein_id="WP_095757919.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.9e-41, bitscore:
                     139.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.3e-39,
                     bitscore: 133.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGTEPHSGAVLEKAAHENFPVAPFFLPRTWRADLMAVYGYARL
                     VDDIGDGDLAPGGTDAVLLGAGPGADGDRLALLDAVETDLRRVFTPGGSPRHPLLRALA
                     PAVRRHRLTPGPFLDLIAANRRDQHVHRCPRYEDLLAYCELSANPVGRLVLAVTGTTSP
                     ERVRRSDAVCTALQITEHLQDVAEDLARGRVYLPAEDMERFGVREDDLRRPTGDARVRA
                     LVRHEADRARALLDEGAPLVGSVSGRLKLLLAGFVAGGRAALAAIAAAGHDVLPGPPRP
                     TRTALLRAAAATLRREG"
     misc_feature    17191..17204
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            complement(17442..18110)
                     /locus_tag="SXIN_RS04435"
     CDS             complement(17442..18110)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037627.1"
                     /locus_tag="SXIN_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_095756610.1"
                     /transl_table=11
                     /translation="MAKGSGGKTGYHHGDLRNALIGAAVELAVEGGPERVVLREAARRV
                     GVSPTAAYRHFSGHGDLLWQVKARGQQALAVFMLEAVREVPPLPDPGEEAERRLAAIGR
                     GYVRFAVENPGLYRTAFRRIPADAPGADGVRAAFAGSAPPGDEPRYSAFRVLTDTLDAA
                     VAAGRMPPAARPGAEIAAWAAVHGLAQLLLDGPLAGLPAGQWETLTDRTVRMVAAGLFG
                     "
     gene            18195..20435
                     /locus_tag="SXIN_RS04440"
     CDS             18195..20435
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358587.1"
                     /locus_tag="SXIN_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MMPL family transporter"
                     /protein_id="WP_095756611.1"
                     /transl_table=11
                     /translation="MFDRIAELALHRARLVLTVTAVAVVAMAALGFGAFGKLLSGGFDD
                     PASPSSRAQVLIDEEFGGEPGLLLLVRADGGRITAPAAERAGRDLAAALRQEPGVSGVV
                     SAWDEGGSALVSRTGDQALVAARVEGDNSEAGERTAELVERYTGDRGPVSVEAGGREAV
                     GHDISGQVSRDLALAEAVAVPVTLVLLVLAFGSLVAALLPLVIGVIAVFGTFAELFVLG
                     SVTEVSVFAVNITTALGLGLGIDYALLLVSRFREQLAAGAEIPEALHRTVRTAGRTIAF
                     SAATVIAALAALLLFPPYFLRSFAYAGIGVVAIAAVAALFVVPALLAVLGHRVARSRFP
                     WARGGGAHSAVWGRLAAVVMRRPALTALPVLALLLVSAAPLLGVTFGTPDERVLPEDAQ
                     SRRVAAALDRDFPAGDREALRIVLDGAVPRQELSGYAREVAALDGVTRVTTAGGSYAGS
                     GAGADAAAAGPGNPALGRPGVQQLTVVHALEPRSDDAQDLVRAVRAVEAPPGAEALVGG
                     EDARLVDAKHAIGSRLPAAAGLIAVTTFVLLFLFTGSVVQPLRALLLNALSLGAALGAM
                     VWIFQDGHLAGLLGFTPQPTDTSMTVLLFCVAFGLSMDYEVFLVSRIKELRDADPEAAP
                     AAAVTGGLARTGRIVSMAAGLLAVSFFAFGTGEVSFIQMFGLGTGLAILIDAIAVRGVL
                     VPAAMRLLGRSAWYAPAPLRRLHRRIGLTEGEAPPGPGAAGESRPLTGVRTG"
     gene            complement(20509..21312)
                     /locus_tag="SXIN_RS04445"
     CDS             complement(20509..21312)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431363.1"
                     /locus_tag="SXIN_RS04445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_019710762.1"
                     /transl_table=11
                     /translation="MAEQHSETHAGGVPASRVPTVIADDLHIVYRVNGGPRGKGSATAA
                     LNRLIRRKAPAGMREVHAVKGVSFTAYRGEAIGLIGSNGSGKSTLLKAVAGLLPAERGK
                     VYTDGQPSLLGVNAALMNDLTGERNVILGGLAMGMSREQIRTRYQDIVDFSGINEKGDF
                     ITLPMRTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQKRSEARIRELRKEAGT
                     VFLVSHNNKSIRDTCERVLWLESGKLRMDGPTDEVIKAYEKESAK"
     gene            complement(21305..22246)
                     /locus_tag="SXIN_RS04450"
     CDS             complement(21305..22246)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133319.1"
                     /locus_tag="SXIN_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_039823128.1"
                     /transl_table=11
                     /translation="MSETTSHKGAVAVSAPPSPDDGLSPAELAAKYGLTVSGARPSLLQ
                     YVRQLWGRRHFILAFSQAKLTAQYSQAKLGQIWQVATPLLNAAVYYFIFGMLLGARGGL
                     DDDVYIPFLVTGVFVFTFTQSSVMAGVRSISGNLGLVRALHFPRASLPISFSLQQLQQL
                     MFSMIVLVGILVAFGHYPRLSWLLVLPALLLQFVFNSGLAMVMARLGAKTPDLAQLMPF
                     LTRTWMYASGVMFPLSYILERAEQIPSWFGEVMLANPAAVYMDLMRFALIDGYGSENLP
                     SHVWALALGWALLAGIGGFIYFWKAEERYGRG"
     misc_feature    22241..22256
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            complement(22365..23246)
                     /locus_tag="SXIN_RS04455"
     CDS             complement(22365..23246)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009339265.1"
                     /locus_tag="SXIN_RS04455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_039823130.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2e-12, bitscore:
                     45.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLGAVVLTMGNRPEELRALLDSVAKQDGDPIEVVVVGNGSPLPE
                     LTVPDLTVRTIELPENVGIPAGRNVGIEAFGPGGRDVDVLLFLDDDGLLPNSDTAELCR
                     RAFAADPELGIVSFRIADPDTGVTQRRHVPRLRASDPMRSSRVTTFLGGANAVRTAVFQ
                     QVGGLPDDFFYAHEETDLAWRALDAGWMIDYRSDLVLFHPTTAPSRHAVYHRMVARNRV
                     WLARRNLPLPLIPLYLGVWLLLTLVRRPSGPALRAWFGGFAEGWRSPCGPRRPMKWRTV
                     WRLTRLGRPPII"
     misc_feature    23221..23240
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 25.06"
                     /tool="antismash"
     gene            complement(23258..24037)
                     /locus_tag="SXIN_RS04460"
     CDS             complement(23258..24037)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049651.1"
                     /locus_tag="SXIN_RS04460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_050931028.1"
                     /transl_table=11
                     /translation="MPKPSVAELRPVVHPPGVKDRRSGEHWAGRLYMRELSLRVDRHLV
                     NTRVTPNQLTYVMTVFGVLAAPALLVPGITGAVLGVLAVQLYLLLDCVDGEVARWKKQF
                     SLGGVYLDRVGAYLCDAAVLVGFGLRAADLWGEGRIDWLWAFLGTLAALGAVLIKAETD
                     LVGVARHQGGLPPVKEAASEPRSSGMALARRAAAALKFHRLVLGVEASLLILALAVLDA
                     VRDDLFFSRLGVAVLAGIAMLQTLLHLVSVLASSRLK"
     gene            complement(24015..25076)
                     /locus_tag="SXIN_RS04465"
     CDS             complement(24015..25076)
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413836.1"
                     /locus_tag="SXIN_RS04465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_019710766.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.6e-20, bitscore: 71.7,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDISAGALDDLAGLLVDQRISASGKLAIAISG
                     GSGAALRERFAPALPGAAWFEVGGGTLDEAIKLADAMKSGHYDAVVGMGGGKIIDCAKF
                     AAARIGLPLVAVATNLSHDGLCSPVATLDNDAGRGSYGVPNPIAIVIDLDVIREAPIRF
                     VRSGVGDVISNISAVADWELSHRETGEQIDGLAAAMARQSGEAVLRHPGGCGDDDFLTV
                     LAEGLVMTGISMSVAGDSRPASGACHEINHALDLLYPKRAAAHGEQCGLGAAFAMHLRG
                     AREQSAHMVEVLRRHGLPVLPGEIGFTDEEFVKAVEFAPKTRPGRYTILEHRNLSTDQI
                     RDAYADYAKAISS"
     gene            complement(25064..25816)
                     /locus_tag="SXIN_RS04470"
     CDS             complement(25064..25816)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="SXIN_RS04470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_019710767.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.5e-09, bitscore:
                     36.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPADNPEATTVLDIALG
                     NFAEVGLTEVAIVVGYRKEAVYERREALEKKYGVKITLIDNDKAEEWNNAYSLWCARDV
                     LGQGVILANGDTVHPVSVEKTLLAARGQGQKIILALDTVKSLADEEMKVITDPEKGVRR
                     ITKLMEPAEATGEYIGVTLIEAEAAAELADALKTTFEKDPDLYYEDGYQELVNRGFKID
                     VAPIGDVRWVEIDNHDDLARGREIACRY"
     misc_feature    complement(26060..26073)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.28"
                     /tool="antismash"
ORIGIN
        1 cccatcgggg ccgtccggcc cgtcgccgaa gacgggctcc ccgtcgacgt ccttgagccg
       61 ttccaccagg gccagcgcct cgtccgcccg cccgcacgcg gcgaggacga ccgccgcgcc
      121 gcggtgcagg gggccgaggt cctcgtccgg cggcgacccc tccacgggga ggtggaccgc
      181 caagtcctcg gcctcacgca ccagttcgac ggcccgttcc cggtccccgc ggcgcgcgag
      241 gacccgggcg acgcccacca gggccatcgc ccgctcaaac gggtcgtaca cgctgtgcgc
      301 gagtccttcc gcgcgcccga agtcccccga ctcggccacc acgggcggca gttccggcgg
      361 cagcgcgcgg ttgcggcccg ccagcaggtc ccgcgccgcc gccaggggcg ccaggttcgc
      421 caggtcgtcc ggttccgtgt cgcgcagcag acgtatcgcg gtgtcgatct cggcgagcgc
      481 ggcggcgtcg ctgccggtgg cgacccggag ccggtcgtgc cggcggacgt cggcggccag
      541 ccgggcggcc cgcacggcgt ccccgaggcc ggtgaccaga cggctgtacg gacggaggag
      601 gtacggcggg gtgctacggg gccagccgcg ctccgcgtac cgggcggccc agcggtgcag
      661 gcgttcccgg taccgctcga tgtcgccgcc cagttggccg agggccgcgg tgtagagcgt
      721 ctcgtgggcg aagaggtggc cgcgggtggc gtcggggtcg tcccggggcg ccgcccggtc
      781 gccgctgctg ccggagttga gggcgtccgc gtagtcccgc acccgcagca gccggccgaa
      841 ggcgctgccc agccacttcc gcaggtccag gtagggccgc ccggtcagct cgtgcaggtc
      901 gcgcggggtg aggctgccgc gggcggcggt gaacagaccg acgagttccc ggccgagttc
      961 gtcctcgccg tagagcgcgt gggacaggtc ccagcgggcc tcgtcctcgg tgtggcgcgc
     1021 ggcctcggcg gtccccagcg gggtgacgac ggccgggttc cgcagcgggt ggccaccggg
     1081 gacgtcctgc ggcaggcccg ggttggggcg gctggtgacg agcacgcgca cctggggcgg
     1141 cagccgcggc ggcagcagcg aggcgatgct cgggccggtg ccgccggggc gggcggactg
     1201 gtcctcgtcc agaccgtcca cgacgagcag cagcgtgccg ccgtcccggg ccacccgccg
     1261 cgcggcctcc tccaggagca gccgccgctc gccgtcccgg gccatcggca gggcgtgcgc
     1321 cgacggggcg cggccggcga tggcggcgag ctggtggacg agggcctcgg tgaaggcatc
     1381 gctgtcggac tggccggcga accgggcggt gatgaagaac cacaccggta cgacaccgcg
     1441 cggcgggtgc agggcgaacc aggcggcgag cgccgtcttg ccggcccacg gcggtgcctg
     1501 gagccagcgg tacggctccc cgccgccgca gaacgcgacg agctccgcca actcctcctc
     1561 cctgccgtcc agccgcggcg gggcgatgtc ccggagctgc gcccggtaga cggactcggc
     1621 gagggcggag gccgccgggg gcagcacgtc gggcagtgcg gcggggtcga gccgggtgtc
     1681 caggcacgcc tcgagggcgt gcagttccgc cggcgcgagg tgttccgccc agcggtccac
     1741 acggctcgcg gcgagccggc ccggcccgtc ggtgcggtgg tgttcggcga cgacgccgat
     1801 gacgtggccg cggctgagca ccacggcgcc cgacataccg gaccacggcg agacagcggg
     1861 accggccgga gggaccgcac cggcggagga gacggccggg ccgggctcgg cgggcgggtc
     1921 ggtgctcagg tcgagcgtgc cctcgcggcg gttggacagc acggcgcagg tggccacggc
     1981 gtgcgcggtg tcgcggtggg acgaaccgtc cgcgtcccgg cggagtttga acagcgggaa
     2041 gccgaccgcg ctgcagcgca ggaccgcgtc ccgctcgccg atccggccga acggcggcag
     2101 ccacggcggc tgttcgccac ccgccgctcc ggggtccacc gacagcaccg cggcgtcgac
     2161 gccctcgtgg cgccacgtga cctcggcgtc gagcgtgcgt tcgcccggcc ggtcggcgtc
     2221 gaaccgtacg cacacccgcg ccgcgtccgc gaccacatgg gcggcggtga gcacccggcc
     2281 gggccggacc aggaggcccg atccgcgccg ggtgccgccg cccgcccgcg tcgcgatgat
     2341 ctcggcgacg cgggtggcgt gcgacggctc ggtgtccact ggccccgtcc cgttcccgtt
     2401 tccccgtccg ttcccgctgc cgtccccgcc gccgtcagcg ttcgccgtcg gcctcgtcgc
     2461 ccgcgatcag ggcgggcccg gcgggacggc cgtcctcgtc ggtccgtacg ggctggaggg
     2521 tgacggtgat ccgctgggtg gccgcccggg tgaggcgtcc ctcggcgccg gcctcgacga
     2581 cccagaagcg gaccctgccg ctgccgcccg cctcccggcc cacctcgacg gccgtttcga
     2641 cctcgaccgg cccggcctcg aaccgcagcg cccgcccctc gccgtccgcc atggcggacg
     2701 tcagctcacg ccgcaactcc cggatcatct cggacagttc gatcacgcgt tccctccccc
     2761 gccgcgcgtg cggggtgccc ccgcacggcc tcgcatccta ctggccgccc cgcgcaggcc
     2821 ccgaggagta cggacggtgc gccgcctccg tcgcgccgcc ggcagccggc ccggcagcac
     2881 cgggcgccgc cgcgcggtca ccgtccgcgg tccgctcccc cgccgcggcc ggcacggcca
     2941 ccgcgcgcca ccacggttcg ccgggcagcg gaccgtcccc gcccggctcg aacggctcgc
     3001 cgggccgggg cgcggcgagc cgtacccccg cctcccgtgc cgccgccgcg gtccgttcgg
     3061 cgggctcctc ccacgggtgc ggcgcgaggt tgaacgtgcc ccagtggatg ggcagcagcg
     3121 caccggccgg tgtcccgccg gacaggtcga ggtgggtccg caccccttcc tccggggtca
     3181 tgtggatctc cggccagtgc tcggagtacg cgccgatctg gatcatcgtg gcgtcgaacg
     3241 ggccgtacgc ggcgccggtc tcggcgaacc cgtggtagta gccggtgtcc ccgctgtgga
     3301 agacccggtg ctccgggccg gccacgaccc aggaggccca cagggtccgc atcccgcgga
     3361 cgagcccccg gccgcagaag tgccgcgcgg gcgtggccgt gagcgtcagc tccccgaccc
     3421 gggccgactc gtgccagtcc agttcgtcga cgcgcgccgg gtcgacgccc cagtgttcga
     3481 ggtccgcccc gacgcccagc ggtacggcga accgggtgcc ggtggccgcc agcgcgcgga
     3541 cggccgccat gtccaggtgg tcgtagtggt cgtgcgagat gacgacgacg tcgaccggcg
     3601 ccaggtcgtc cagcggcagc ggcacggggt gcagacggcg cggtccggcg aaggcgaacg
     3661 gcgagcagcg ctcgctccag accgggtcga acaggacccg gtgaccgtcg atctccgcga
     3721 gcacgctgga gtgccccatc caggtcagcc ggagaccgga cgggggcggg gcgttccggg
     3781 tctccgcggc gggccggtgc acgggtatgg cgccggcggg cgcgcggcgt ctgcgcgcct
     3841 cccggtcgaa ctgggcgcgc agcagcgccc ggccggagcc cggcagcatc atgcgggtgg
     3901 gcaccgggtt gcggaactgc ccgtccgccc actgcggcga tctgcggatg cgttcgagac
     3961 gctccccggc cgggtccgcg ccgaaggccg cgggccgcag ccgggcggcg agggaccgca
     4021 gcgccccggg ggcggcacgc cgcgggcggt tcgggcgggg cgcgggacga atcccggggc
     4081 ggggcgcgga gctggattcg ggttcgggca cgggacctcc gtggggcggc tgctcggtgg
     4141 tgcgccgcgg ccctcgccgc ggcgcccggt ggtgtccgcc ggctgtgccg ccggcgctgt
     4201 gctcgacagg agaacggtgg ggcggtccgc aaaatgcccg caccgcgccg ccgcccgggg
     4261 tccgtcttcg cccccggcac ggcggagccg gcccccgggt gacggcgcgg ccggacggag
     4321 gccggtccgc tcggcagccg tgcgggcacg tacgggggcc gggcccgccg tccgtacgcg
     4381 cgggcccggc ccccctgccc cgtcggccgt tcagggcttg cggcccacgc ctccgtagca
     4441 cgcgacggtg cgccctccgg cctcgccggc cttgccggtc ccctcctcgg gacgccaggc
     4501 cgtggcctgg accagtcccg ggtcgagcag ttcgtagccg ttgaagaagg gcaggatgcg
     4561 ggcgtggtcg cgcagggtga ggtgggccgt ggtccggtcg tagaccttga cgacatcctc
     4621 accctccgcg cgcctccgac tctctccgtg gaagtcggcg gtgacgtggc tgaggatgag
     4681 atggcttccg gcgggcaggt cctcgccgag ggcggcgagg atgccctccg ggtccgaggc
     4741 gtcgtcgatg aagtgcagga cggcgacgag catcagggcc accggctggt cgaagtcgat
     4801 gagccggcgg atggtggggt ggtcccggat ggtgcgcggt tcccggacgt cggcgtggac
     4861 gaaggcggcg ttgccctcgt tggtcagctt ggcctccgcg tgggccgcca cgatgacgtc
     4921 gttatcgacg aatgccaccc gggtgtccgg cgcgatctcc cgtgcgatct catgggtgtt
     4981 gggcgaggtg gggatgccgg tgccgatgtc gatgatctgc cggacgcccg ccttgacgac
     5041 ggtccgcacg gcccgctgca tgaaagcccg gttcgcccgc gcggtggccc gggtgtccgg
     5101 ggccagcttc atgacgtcct ccgcggccgc gcggtcgacc tcgtagttgt cccatccccc
     5161 gaggtagtag tcgtacatcc gggcgggatg cggtctgctg gtgtcgatat gttcgacagg
     5221 gaaaccctgg tcggtcacac cggtctccat ttctgtcttc cccctgtccg tggggagttc
     5281 ccccgtgtcc gtgcgggaaa gccggccggc tcggtcgggg cgggccggcc cggtcaggcg
     5341 aggaggaagt ccgcctcgcc gtccttcgcg ccacggatga aggtcgcgat ttcgtgatgg
     5401 ctgtatatca gggcggggcc gtccgggtcg gtggactgac gcagcgcgac ccttccgtca
     5461 cccagcttca tggcctccac acaactcccc ccgtttccgc cgctccacgg cttgtgccag
     5521 ccctccgtgc cgagctccgt ggagggcatc ccgttgtaaa tacgtttcct gcgatccatg
     5581 gttcagatct ccttgcgaat cccacccagc accgtccggg tggtgtgtgc gggcgcggct
     5641 tgcgcgcaca tccggtccag ggcctccagg aacgccgaca cgtcgtcccg ctggtcgacg
     5701 tagacggcgc cgacgaggct ctcggagtag acgacgtccg gcagttccgg gagcggaaac
     5761 cggaagatgt gaaagggacc gtacatggcc gggtgcggac ccgcggagaa gggcatgagc
     5821 tggagtctga cccgcggcat ctcggtcgcc tcgatgagcc ggtcgatctg tgcgcgcatc
     5881 acctcggggc cgccgatcgg gcggcgcagg accgtctcgt ccatgacaac ccacagcagc
     5941 ggcgggtcgt ccttggtcag cagggactgg cgctcggcgc ggagtgcggc gaggcgctcc
     6001 acttcggcct ggggcgcgtg cggcatcccg gcgcggagga cggcgcgcgc gtaggcctcg
     6061 gtctggagca gcccggggac gtagtgcggc tcataggcgc ggatgacgct cgcctctccc
     6121 tccagggcga cgaaggcgct gaaccactcg gggaggacat cgcggtagcg gtgccaccag
     6181 cccggctggt tggcctcccg cgccagggag acgaaggcgt cgatgtcccg ctggtcggta
     6241 acgccgtaga cccggaggag cttctccaca taggggattt tcagcccgac ttcggccttc
     6301 tccatccggc ggaccgtggc gtgggtgacg tcgagggcgc ggcccgcctc cgcgaacgac
     6361 agcccggccc tctcccgtag atcctgcagg cgcttgccga gcaccagcct caggacggtc
     6421 ggcgcacctc ccgaccgcgc gtccttcacc gcacatcccc tccaacaacc ttgacccggg
     6481 cgcagtctgt catggggtca gctgagcggg ccaggctgtc gtcagcgttt tgtgatttac
     6541 agactgatcc ttgccatgcg tgagtgacaa gcctcatagt tgcagcgtgg ctccttccca
     6601 tgaagcgctc cggctgagcc gctgcggcgg cgtcgtcgcc cggcatctcg aggacgtgtt
     6661 ccatctgccg gcgatgagcg cctcggtctg caaggcccgg cggcgtgtcc tcacgctgct
     6721 ctccgagtgg ggcgtcgacg agcgctgccg cgcggacgcc gaactggtgg tgtcggagct
     6781 gttcaccaac gccgtgcggc acaccgacag cgtgaaggtg acctgcgaga tccggctcac
     6841 cggacagcgg ctgcggctgg aggtcaccga ccagggctgc gcggagaccg agccgcgcgc
     6901 ccggttctcc gggatcgacg aggagggcgg gcgcgggctg atgctggtcg gcgccctggc
     6961 ggaggagtgg ggcgtccggc cggacgagac cgggcgcggc caggtggtct gggcctgtct
     7021 gcgccgctcc gggagaaccg ccgccctctg agccgccggc ccgtggctcc cgaaaccgcc
     7081 gggacaccgc ccgccggggc accccgcccc ggtctggctc ccccgcgccg gcccgtctct
     7141 ctccccccgc gccctcccgt ccgtcgtcag gtccgctttc cgtgacgcgt tccacagcgc
     7201 gggccggtgc gggccggatc gggccaggtg gagcgcggtc cggcggaggt ccggcagcat
     7261 gggggaaccg gttgcccggg taatccatat cgtagggtca gcagcatcag gagcaccgcc
     7321 tcgtcggcga gagggccggc ggccgacacc gaggagcgcc cgtgacgcag acgcctcagg
     7381 tcccccaggc cgagcagacc gagccccggc tctcgggtgt gcggaacttc cgcgacgtgg
     7441 gcggcctgcc gaccggcgac ggccggacgg tccggcgcgg ggtgctctac cgcagcgggc
     7501 atctggcgaa ggccaccgcc gcggacgcgg cgttcctctc ctccctcgga ctccacacgg
     7561 tcttcgactt ccgcaatgac gccgatgtgg ccctcgacgg ccacgacatc gcgctggacg
     7621 gcgtgcgcca tgtgaacatc ccgctgaccg accccgccga cggcgcggag ttctggcgga
     7681 tggtgcggga cggcgacctg acgcagctcc gcgccgcgct gggcgacggc aaggccgccc
     7741 tgcggatgtc gagcacctac cgcgtcatca tgaagacccg caccaccgag cacagccggg
     7801 tgctgcacgc actcgccgag gacagcgtgc ccgcgctgat gcactgcgcg gcgggcaagg
     7861 accgggcggg gctgtcggtc gcggtgaccc tgctcgccct gggcgtcgag cgggacgcga
     7921 tcgaggagga ctacctcgcg agcgccgccc cgcaccgccg ctaccggttc cgccgctcgg
     7981 acgactcccc cgccgccctg acgccggagg tcgaggatct cctgagcccg ctcttcgacg
     8041 cccggcggga gtacctggac gccgcgttca cgacgatcga ggaggagtgg gggacggtcg
     8101 acgcctacct cacccggggg ctgggcttcg ggcccgaccg gcgcgagcgg ctgcgggccc
     8161 ggatgctcga cggctgagcc ggccggcttt ttcgggctgg atcgtgcggc ccgcccggac
     8221 ggcccgcccg cacggccgga cggcacggcc tgccggtgcg gacgagcgga ccctccgcac
     8281 cggcaggacc gtcccgcggc cccgccgcct ccctcccggc cggtctcagc cggccgtctc
     8341 gcgcagcgcg cgcagcgact gccgcagcga gccgagggtg gcgaggacgg cggtcggttc
     8401 gtagccgcag tgcgccatgc agttggcgca gcgcgggtcg cggccccgcc cgtaggcgtc
     8461 ccagtcggtc tcctcgatga gctcccggta ggtggggacg tagccgtcgc tcatcaggta
     8521 gcagggccgc tgccagccga agagggagta gttggggatg gcccaggcgg tgcaggggaa
     8581 gtccacccgg ccttccagga agtcgaggaa gagcgggctg tggttgagcc gccaccggcg
     8641 ccggttgccg cccgcgaagg ccttggcgaa cagctcgcgg gtctgggcga cgccgaggaa
     8701 gtgctcctgg tcgggggctt tctcgtaggc ataggcgggc gagatcatca tctcgtccac
     8761 cagcagctcg tcgttgaggt agtcgaggac ctcgatgatg gtctgcgggg tgtccgtgtt
     8821 gaagaaggtc gagttggtgg tgacccggaa gccgcgccgc ttggcctcct tgatcgcctc
     8881 gacggcctcg tcgaacacgc cttccttggc gacggaggcg tcgtgccgct cgcgcagccc
     8941 gtcgatgtgc accgcgaagg cgaagtagcg cgagggttcg aatttctcga tgttcttgcg
     9001 cagcaggacg gcgttggtgc agaggaagac gtacttcctg cgtgcggtga gctgccgcac
     9061 gatctcgtcg atctgcgggt gcatcagcgg ttcgccgccc gcgacggaca ccatgggcgc
     9121 gcccgactcc aggaccgcgc cgacggcctg ggcgacgggc atccgctgtc ggagcacccc
     9181 ggccgggtgc tggatcttcc cgcagccctc gcacttgagg ttgcaggcga agagcggttc
     9241 cagctcgacg atcagcggga acttctcccg gcggcggagc ttctgggcga agagataggt
     9301 tccgacccgg atggattggc ggagcggcat ggccatctgg ctcacctcct ggggagcggc
     9361 agggaacggt gccattcgta gaaagccggc aggacggtcc gcaggacgcg gaaggccgat
     9421 attccaccga gcaccgtgcc gccccgggcc agttcgcgct ccggggtgtc cacgaccacc
     9481 cgtacggcgg caacggggcg cggccccgcg gccagcgcgg tgcggaggac ggcggcggac
     9541 tccatgtcgg cggcgatcgc tccggtcgcg tgcaggcggg cacgctcggc gccccgtacg
     9601 aggtggtcgg tgccggcgag cggtccggtg tggacggcgg tgccggaccg ggcgcggccg
     9661 gcacgcccgg ccagggcgcc ggccagggcg gcggtgcccg cgcagggcac gcgcccgatc
     9721 cggtcgcggg tctcggcggc gacgaccagg tcgccggggc gcatccccgg ggcgagcgcc
     9781 gcgcagaagc cggtggcgag gacgggcgtg ccgaccgcgt acgggtcggc ccggcgcagg
     9841 ccgcggagca cggcgcgttc ggcggaccgg gggcccatgc cggtgcgcag gacggtcagg
     9901 gcgcggggtg cgccggtccg gtcgccgccg cgcagggcaa gccgttcgat ggagagcgcg
     9961 caggcgatca gcagcgtcgc gggaccgccg tcctcggcca tcaggcgtcc cgcgggacgg
    10021 tccggggctg ccgccccacg gcggtcaggt accggccgag ggcggtgagc gggaacacca
    10081 gccggtagag gtggtagttg atggagaagt cccaggggaa gccggtgccg gtgaactggg
    10141 gttcgtccca ggagccgtcc tcgcgctggg tgcgggcgag ccagccgatg ccgcgttcga
    10201 cggccttccc gtcctcctcg ccggcggcga gcagggcgag gagggcccag ccggtctggg
    10261 aggcggtgga ctcgccgcgg gcgatccact cggggtccgg gtaggagcgc aggtcctcgc
    10321 cccagccgcc gtcctcgttc tggacgctgc tgagccagtc gacggcacgg cggatcgcgg
    10381 ggtgctccgc ggggacgccg gccgcgacga gggcggggac ggcggagccg gtgccgtaga
    10441 ggtaattgac gccccagcgg ccgaaccagg caccgctcgg ctcctgttcg gcgagcagcc
    10501 acgcgacggc gcgccggacg cgcgggtcgg cggccaggcc ctcggcggcg agcatctcga
    10561 cgacgtgcgc ggtgacgtcg gcggacggcg ggtcgatgac ctcgccgaag tcgcagaacg
    10621 gcagccggtt ggggaaggcg ctggtgttgt cggcgtcgaa agcgccccag gcgccgtccg
    10681 cggactgcat gccgagggtc cagcggacgg cgcggcggac ggcccggtcg acccgctcgg
    10741 gctcggggtg ggcggtgcgg cggagggcga ggacgacctc ggcggtgtcg tcggtgtccg
    10801 ggtagttgtc gttgtggaac tcgaacgccc atccgcccgg aggcagtccg ggccggcgga
    10861 ccgaccagtc gccggggcgc agcacctgct cgccgagcat ccagtcggcg gctctgacga
    10921 gcgcggggtg tccggcgggc agcccggcgt cggtgagggc gatggtggcc aggcaggtgt
    10981 cccagaccgg ggactggcag gcctcgatca tgcggctcgg accgccgccg gggccgggcg
    11041 cgtcctgcca gacggcgaac cggtcgagcg agtcgagccc ggcgcgcagc acggggtggt
    11101 cgaggtcgta gccgagcagg tggagggcga tgaccgagta gacggcgggt ggctggatgc
    11161 cgccccagca gccgtcgttc tcctggcgtt cgacgatcca gcgggcgcag gcccgcagcg
    11221 ccgcgcgccg cagcgggggc ggcgccaccc ggcggtaggc gtgcaggagg cggtccaggc
    11281 gccggaagac gcggtcccag ccggtggcgg tggccgcggc gcggcgcggc gcggccgggt
    11341 ccgggtggag ttcgccgagg gggaaggggg cggggcgcac cgggcgcagg gcggacacga
    11401 cggtgagcgg cacgatggtc tgccgggccc agcagccgaa gtcgtagatg ttgagcggga
    11461 accacttcgg caggtagatc atctcgggcg gcagttcggg cagctgttcc cagggccacc
    11521 agccgaagag cgcgagccag atccgggtga agacgcggga ggcggcgatg ccgccgtgct
    11581 cgcgcaccca ggcggaggcg gcggccatgt gcgggtccgc gggggcgtcg ccggcgagcc
    11641 ggagggcgac gtaggcctcg atggtggcgg agaggtcgcc gggaccgccg tggaaagtgg
    11701 cccaggtgcc gtccgggcac tggcgggaac ggatgaaacg ggccgcggcc tcggtggtcc
    11761 gccggtcgcc gatgccgagg aactcgcgga gcagcaggtc ctcggcgtcc atggtgacgt
    11821 tggtctccag gtcgcccttc caccagccct cgtcgtgctg ccggccgagc aggttccgca
    11881 ccgcccgcgc ggcggcgcgc tcggctgcgg cgggggtgtc ccggggaccg ggggcgggag
    11941 ggcgcgggtc cggggttccg gactcccggc gggggccggc ggattccccg gcgggcgcgg
    12001 cgggcggcgc cgggagcggg ccgggcgggc cgccggccgg gagggcgggg ggccgtgggc
    12061 ccgagctgcc gtcggtcgtc gctgtcatgg cttccccttc gtgcagtgaa cgcgctctgc
    12121 tgtgctgggg tgcgcaccgg ccgccgcgcg ccgcccgggg agggcgtgcg gcggcggccg
    12181 gtgacagcgg tctatatgtg ccggcggtgc tctccgcgga cggccgctcc accggccggt
    12241 ggagcggtcg gtggagcggc cggtggggcg gtcgtcccgc acggtgcgag cccggtcatt
    12301 tccgccgcac gaccacgaag tccgcgaggg cgacgagctg ttcgcggacg tgcggatcca
    12361 ggtcgacccg gtccagcgcg ccgatcgcgg cggtgtgctg ccgctgcgcc tcctgagagg
    12421 tccaggtgcg gccgccggcc tcctcgatga gcgcggcgcg ctcggcgaac tccgtctcgt
    12481 cgaagtcctc ggtgcggtcg ctcttggcgt cgacggcgag gatggcggcg agccggtcgg
    12541 aggcggctcc gccggcggcg agggcggcga cgaccggcag ggacttcttc cgctgccgca
    12601 ggtcgctcca ggtctgcttg ccggtcgcct ccgggtcgcc ccagatgccg agcagatcgt
    12661 cgaccgcctg gaaggcgaga ccgaggtggt ggccgtagga ctccaggctg tcggcgaggt
    12721 ggtcgtcggc gccgccgagg acggcgccga tcgaggtggc gcaggcgagc agcgcgccgg
    12781 tcttgttgcc ctccatgcgc aggcactcct cgacggtgac ccgctcccgg tgctcgtagg
    12841 agatgtcctg ggcctggccg tcgatgagct tgcgggtcgc ggtggtcagc cgtctcgcgg
    12901 cgcgggccgc ctcgggcgtg cccatctcca gcaggatctc cccggccagg gcgaagaggg
    12961 cgtcaccgac gaggacggcg agggcggggc cgtgcacctt ccagacggtg tcgcggtggc
    13021 ggcgctgctc gtcgccgtcc atgaggtcgt cgtggagcag cgagaagttg tgcaccagct
    13081 cgacggcgac ggcgcccggg acgccggtct ccggcgccgc acccgccgcc tcggcggaga
    13141 gcagcgcgag cgccgggcgg accgccttgc cgccgtcgcc ctcggcgggg cggccctcgg
    13201 cgtcgatcca gccgaagtgg taggcggcga cggtgtccat gggcggtgcg agccgggcca
    13261 cggcggcccg cagcaccggc gtggcgagcg tccgtccgcg cagcagcagc gcggggacgt
    13321 ccgcggtgtc gatggcgggt tgcgccgtgt tcactgtctc tccttcggtt cctctgcggt
    13381 cgtgggtgcc gggccgcgcg tctgcccgct ctgtctccgg gggccgcgcc cccggggccg
    13441 gcacggggtg cgcgggccgg ggggtcgcgg cgtgggatgt gccggtcatg cggccctgcc
    13501 ttcctgggtg cgtgcccgcg gcgtgcgccc cggggacggg gcgggtgggg cggtgaaggc
    13561 cgcggtgccg gccgccccgg gcggtccggg gagccgggcg gcggtacggg ctgccgtgcg
    13621 gtgccggtgc tccgtcccgt ggcgtggtgt cggcatcagg cagcctcctg ctgggggtcc
    13681 acccggccgg ggcccggggg cgggtccggg tgggtgcgga cggtgcggag gtggcgcagg
    13741 gccgcggcgg cggcggtggc gccgctgcgg gccgcgccct ccatcgtggc gggccacccg
    13801 gtggcggtcc atgcccccgc gagttggagg ccggggacgc gggtgcgggc gggcgggcgg
    13861 agccgtccgg tgccgggggc ggggtcgaag gtggcggcgc gctcgcgggt gacgaagaag
    13921 tcggcgaccc gcgcgttccg ggcgccgggc agcagccgct ccagctcggg caggaagcgg
    13981 cggcggagct ccgcgacggg caggtcgatg atgtctccgg cggccgactg cgacagggcg
    14041 aggtactggg cgccgccggt gagcccggag ggctccgtcc ggtcgaagac ccattggacg
    14101 gggctgccca gcgcggcgag gaaggggcgg cgcagcaccc tgcgatcgta gacgacatgg
    14161 acgttgagga tcggcgcggt cccgatgtcc agcagccgcc cggggtcgtc cagggcaccg
    14221 tcgggcagca gccggtgtgc ctcgtcgtgc gggacggcga ggacgacggt gtcggcgcgc
    14281 agcgtctccg ggccgcccgg tgcggtgacg gcgacccgcc agccgccgga gcccgcgccc
    14341 cggcggtgca gcgcgcgggc gcgggtgcgg agcaggacgc gcacgccggc gccctccagg
    14401 gcccggcggg tgcgggtgtc gtggagttcg ccgagcggca cccgggcccg gccgatgtcc
    14461 gccgcgcccg gtgcggagag cagtccggtg cggaagacca tggcggccag ggccagggac
    14521 gcccggtcgg cgggggcgtt gagggtggcg acgccgatga ggtcccacag cgcctccacc
    14581 gcgcgcgggg actggccctg ccggcggagc cagccgccga agtcggtgcc gtcgagcgcc
    14641 ggatcggcgg ggtcgaggcg gcgcagggcg agcgcggcgc gggcggccgc ggcgcgttcg
    14701 gccggggaga ggtgcggata gcgggcgagg gagccggcga ggtggagcgg tacgggcagg
    14761 gcggagcggc gcagccgtcc ggcgcggttc cgggcggcgt cgaggacggg cacgtcgagg
    14821 cggtgctgga cgggcgccag gccggcggcc ccgacgcgct ccaggagcgc gcggtaggcg
    14881 gtgcaacagc gcaggtggac gtgctggccg ttgtcggcgg tgaggtcccc ggccggggag
    14941 gagcggcgga aggagaaggc gagcccgccg aggcgcggcc gggcctcggt gagggtgacg
    15001 cggacaccgg cgtcggcgag ggcgagggcg gcggccgtgc cggcgatgcc gccgccgacg
    15061 acgacggcgg tccgcccggc ggcacggtac gggccggggc cgccggcggg cgcggcgggg
    15121 ccgggccggg gcggggacgg ttcgggaacc ggcgggcgca tcaggcgcgg cctccggccc
    15181 ggccggcccg gtggcgggcg gtgcggcggg tgatgtgccg ggcgtccagg ccggacaggc
    15241 cgcgcacggc gacgtacgcc ttctcgggtg cgggcaggga gacccggccg tgcaggacgg
    15301 cctcggggtc gcgggcgatg cggtccagca gccggcggta gatgccggcc atggcggcga
    15361 cgcaggcgcc gctgcgccgg tcgaggagcg gcagcagccg gaagccctcg gtgaacaggg
    15421 cgcgggcgcg ccgcgcctgg tagtggacga ggccggtgaa gtcggcgccg gccggcggca
    15481 cgggggtgtg gaagccggcg gcgcagccga acttggcgag gtcgtcggcg gggaggtaga
    15541 ggcggccgtg ggcggcgtcc tcgcggatgt cccggaggat gttggtgagt tggagggcga
    15601 ggccgagggt gtcggcgtac tcgggggcgc gttcggtctc gcgggcgccg tggccgtggg
    15661 ggctcgtgac cccgaatacg ccgagggaca gccggccgat cgtgccggcg acccggcggc
    15721 agtacgtccg gaggtcgtcc caggtgtcgt aggtctcgcc gcgcacgtcc atcaggacgc
    15781 cgtcgatgag ttcgtcgagc gcggccaggg ggatcgggaa acgctcggcg gcgtgggcga
    15841 gggcgacggc gacggggtcg gtgtcgtcgg tacggacgcc gccgtcgcgc acccgtgcga
    15901 ggagggcgcg ggtgtcgtcc aggcgggcga gcttggcgga cgcggggagg tcgccgtcgc
    15961 cgatgtcgtc gacgcggcgg gagaaggcgt acagcgccga catggcctgc cgtttgccgg
    16021 ggggcagcag gcggatgccg taggcgaagt tgcgggcctg gtgcccggtg acggtctcgc
    16081 agtagcggta ggcggcgagc accggcgccg gtacggaagc ggacgcgggt gcggaggcgg
    16141 acggggtcac ggtccggctc acccctctct tcgcagtgtg gcggccgccg cgcgcaggag
    16201 ggcggttcgg gtgggcctgg gcggtccggg caggacgtcg tggccggcgg cggcgatggc
    16261 ggccagcgcc gccctgccgc ccgccacgaa gccggcgagc agcagcttga ggcgtccgga
    16321 gacgctcccc acgagcggtg cgccctcgtc gagcagggcg cgggcgcggt cggcctcgtg
    16381 gcggaccagg gcgcgcaccc gcgcgtcgcc ggtggggcgg cgcagatcgt cctcccggac
    16441 gccgaagcgc tccatgtcct cggcggggag gtagacgcgg ccgcgggcga ggtcctcggc
    16501 gacgtcctgg aggtgctcgg tgatctgcag ggcggtgcag acggcgtcgg agcggcggac
    16561 gcgttcgggg ctggtcgtgc cggtgacggc gaggacgagc cggccgacgg ggttggcgga
    16621 gagttcgcag taggccagca ggtcctcgta gcgggggcag cggtggacgt gctggtcccg
    16681 gcggttggcg gcgatgaggt cgaggaacgg cccgggggtg agccggtggc ggcgcacggc
    16741 cggggcgagg gcgcggagca gggggtggcg cgggctgccg ccgggcgtga agacgcggcg
    16801 gaggtcggtc tcgacggcgt cgagcagggc gagccggtcg ccgtcggcgc ccgggccggc
    16861 gccgagcagg acggcgtccg tcccgccggg ggcgaggtcg ccgtcgccga tgtcgtcgac
    16921 gaggcgcgcg tagccgtaga cggccatgag gtcggcgcgc caggtgcggg gcaggaagaa
    16981 cggggcgacg gggaagttct cgtgcgcggc cttctccagc acggccccgg agtgcggttc
    17041 cgtgccggcg gtcaccgggg cccgcccggt gcccggcaca cggcgccgcg ggcggcgggc
    17101 ggcggggtgc gccgcgggac ggcggcgtcc cggagctgag gggttcccgt agccatggcc
    17161 gtcacatccc ctgttctaca ccgtccaccc agaacatacg atttcggaca cgccgcacgg
    17221 gggacgcgcc ccggcgccgt acgcgcgggc cgatggcgcg gcgtttggga ggacttgccc
    17281 gtgaatcggc gccgcccagc ctaggcgatg cgggcccggg cggcgcaccg tggccggtgg
    17341 tggcgcgggg cgtttcgccc ggggcgcggg gggcgggtcg ggtccggcgg agcggggggc
    17401 gccggaccgc cggaccgccg ggtcctccac ccgtccggat gtcagccgaa gaggccggcc
    17461 gcgaccatgc gcacggtgcg gtcggtgagg gtttcccact gcccggccgg gagcccggcg
    17521 agcggcccgt cgaggaggag ctgggccagg ccgtgcacgg cggcccaggc cgcgatctcc
    17581 gcgcccgggc gggccgccgg cggcatccgc ccggcggcga cggccgcgtc gagcgtgtcg
    17641 gtgagcaccc ggaaggcgct gtaccggggc tcgtcaccgg gcggggcgga ccccgcgaag
    17701 gccgcccgga cgccgtcggc cccgggcgcg tcggccggga tgcgccggaa ggccgtgcgg
    17761 tagaggccgg ggttctcgac ggcgaagcgg acgtagccgc ggccgatggc ggccagccgg
    17821 cgctcggcct cctcgcccgg gtcggggagc ggcggcacct cgcgcaccgc ttccagcatg
    17881 aagaccgcca gcgcctgctg gccgcgggcc ttcacctgcc agagcaggtc gccgtggccg
    17941 gagaagtgcc ggtaggcggc ggtgggcgag accccgacgc ggcgggccgc ctcgcggagg
    18001 acgacccgtt cgggaccgcc ttcgacggcg agttcgacgg cggcgccgat cagcgcgttc
    18061 cgcagatcgc cgtggtgata accggtcttg ccgccgctgc ctttcgccat gccttcatcc
    18121 tgccccatgt tgacagcagt aacatcctct gccaccttgc atgttaatgc cgtaaacatc
    18181 ggagggggat tcccgtgttc gaccgcatcg ccgagttggc cctgcaccgg gccaggctcg
    18241 tcctgaccgt caccgcggtg gcggtggtcg ccatggcggc gctgggcttc ggcgccttcg
    18301 gcaagctgct cagcggcggc ttcgacgatc cggcctcacc gtcgagccgc gcgcaggtgc
    18361 tgatcgacga ggagttcggc ggagagcccg gcctgctgct gctcgtccgc gcggacggcg
    18421 gccgcatcac cgcacccgcc gccgagcgcg cgggccggga cctcgccgcc gcgctgcgcc
    18481 aggaaccggg ggtctcgggc gtcgtgtccg cctgggacga ggggggttcg gcgctcgtct
    18541 cccgcaccgg cgaccaggcg ctggtcgccg cccgggtcga gggggacaac tccgaggccg
    18601 gcgagcgcac cgcggaactc gtcgagcgct acaccggcga ccggggcccg gtctccgtgg
    18661 aggccggcgg acgggaggcg gtcggccacg acatctccgg gcaggtctcc cgggacctcg
    18721 ccctggccga ggccgtcgcc gtgcccgtga cgctcgtgct gctcgtcctc gccttcggca
    18781 gtctggtggc cgccctgctg ccgctggtca tcggggtgat cgcggtcttc ggcaccttcg
    18841 ccgagctctt cgtgctgggc agcgtcaccg aggtctcggt cttcgccgtg aacatcacca
    18901 ccgccctcgg cctcgggctg ggcatcgact acgcgctgct gctggtcagc cggttccggg
    18961 agcagctcgc cgccggcgcg gagatccccg aggcgctgca ccgcaccgtg cggaccgcgg
    19021 gccgcaccat cgccttctcc gcggccaccg tgatcgccgc gctcgccgcc ctgctgctct
    19081 tcccgccgta cttcctgcgc tccttcgcct acgcgggcat cggcgtggtg gccatcgcgg
    19141 ccgtcgcggc gctcttcgtc gtccccgcgc tgctcgccgt gctgggccac cgggtggccc
    19201 gcagccgctt cccgtgggcg cggggcggcg gcgcgcactc cgccgtctgg ggccggctcg
    19261 cggccgtggt gatgcgccgc cccgcgctga ccgcgctgcc ggtgctcgcc ctgctgctgg
    19321 tctcggccgc cccgctcctc ggggtcacct tcggcacccc cgacgagcgg gtgctgcccg
    19381 aggacgccca gagccgccgg gtcgcggcag cgctggaccg ggacttcccg gcgggcgacc
    19441 gggaggcgct gcggatcgtc ctggacgggg ccgtaccgcg gcaggaactc agcggctacg
    19501 cacgggaggt ggccgcgctg gacggcgtca cccgggtcac caccgccggc ggctcctacg
    19561 ccgggagcgg cgccggtgcg gacgcggccg ccgccgggcc ggggaaccct gcgctcggcc
    19621 ggcccggagt ccagcagctc accgtcgtcc acgccctgga gccccggtcg gacgacgccc
    19681 aggacctggt ccgggccgtc cgggccgtgg aggcaccgcc gggagcggag gcgctggtcg
    19741 gcggcgagga cgcacggctc gtggacgcca agcacgcgat cggctcccgg ctcccggccg
    19801 ccgccggact gatcgccgtc accaccttcg tcctgctgtt cctcttcacc ggcagcgtcg
    19861 tccagccgct gcgggccctg ctgctcaacg cgctcagcct cggggcggcc ctgggcgcca
    19921 tggtgtggat cttccaggac ggccatctgg cggggctgct gggcttcacc ccgcagccga
    19981 ccgacacctc gatgaccgtc ctgctgttct gcgtcgcctt cggcctctcc atggactacg
    20041 aggtcttcct cgtcagccgc atcaaggaac tgcgggacgc ggacccggag gccgccccgg
    20101 ccgccgccgt caccggcggg ctggcccgca ccgggcggat cgtgtccatg gccgccggcc
    20161 tgctggccgt gagcttcttc gccttcggca ccggcgaggt cagcttcatc cagatgttcg
    20221 gactcggcac cggactcgcc atcctcatcg acgccatcgc cgtacggggc gtcctggtac
    20281 cggccgccat gcggctgctg ggccggtcgg cctggtacgc gcccgcgccg ctgcgccggc
    20341 tgcaccggcg gatcgggctg acggagggcg aggcgccgcc cgggcccggg gccgccgggg
    20401 agtcccgtcc gctcacgggg gtgcggacgg gctgacacgg cggagccccc gccgggacgg
    20461 tgaaccgtcc cggcgggggc tccgtggtgc gcgggggcgg tgtccgggct acttcgcgga
    20521 ctccttctcg tacgccttga tgacctcgtc ggtcggcccg tccatgcgga gcttgccgct
    20581 ctccagccac agcacccgct cgcaggtgtc gcggatggac ttgttgttgt ggctgaccag
    20641 gaagaccgtg ccggcctcct tgcgcagctc gcggatacgg gcctcggagc gcttctggaa
    20701 cttccggtca ccggtggcca gggcctcgtc gatcatcagg acgtcgtggt ccttggccgc
    20761 ggcgatggag aagcgcagcc gggccgccat gccggaggag tacgtgcgca tcggcagggt
    20821 gatgaagtcg cccttctcgt tgatcccgga gaagtcgacg atgtcctggt agcgcgtgcg
    20881 gatctgctcg cgggacatgc ccatcgccag gccgccgagt atgacgttcc gctcaccggt
    20941 gaggtcgttc atcagggccg cgttgacgcc cagcagggac ggctggccgt cggtgtagac
    21001 cttgccgcgc tcggcgggca gcagcccggc cacggccttc agcagggtgg acttgccgga
    21061 gccgttggag ccgatcaggc cgatggcctc gccgcggtag gcggtgaagg agacgccctt
    21121 cacggcgtgc acctcccgca tcccggccgg ggccttgcgg cggatcagcc ggttgagggc
    21181 ggcggtggcg ctgcccttgc cgcgcgggcc gccgttgacc cggtagacga tgtggagatc
    21241 gtccgcgatg acggtgggca cgcgcgatgc ggggacgcca ccggcgtggg tttcgctgtg
    21301 ctgctcagcc acggccgtaa cgctcctcag ccttccagaa gtagatgaac ccgccgatgc
    21361 cggcgagcag agcccagccg agggcgaggg cccagacgtg gctgggcagg ttctccgagc
    21421 catagccgtc gatcagcgcg aagcgcatca ggtccatgta gacggcggcg gggttggcca
    21481 gcatcacctc gccgaaccag ctcgggatct gttccgcccg ttccaggatg tagctcaggg
    21541 ggaacatcac gccggaggcg tacatccagg tgcgggtgag gaagggcatc agctgggcca
    21601 ggtccggggt cttggcgcca agtctggcca tgaccatggc caaaccggaa ttgaagacga
    21661 actgcaacag cagagccggg agcaccagga gccacgacag ccgcggatag tggccgaaag
    21721 cgaccaggat ccccaccaga acgatcatgg agaacatgag ctgctggagc tgctggagcg
    21781 agaaggagat cgggagcgag gcccggggga agtgcagtgc cctcaccagc ccgaggttcc
    21841 ccgagatcga ccggacaccg gccatcacgg agctctgggt gaaggtgaag acgaagacgc
    21901 cggtcaccag gaaggggatg tagacgtcgt cgtccagacc gccccgtgca ccgagcagca
    21961 tgccgaagat gaagtagtac accgccgcgt tcagcagcgg tgtcgccacc tgccagatct
    22021 ggcccagctt cgcctggctg tactgggcgg tcagcttggc ctgcgagaag gcgaggatga
    22081 agtggcgccg tccccacagc tgccggacgt actgcagcag agagggccgg gccccgctca
    22141 ccgtcagtcc gtacttcgcg gcgagctcgg ccggggacag gccgtcgtcg ggggaaggcg
    22201 gggcgctcac cgcgaccgca cccttgtgcg atgtcgtctc actcacaagt ggaaactttc
    22261 gctctctaga tacgcagcca gaaggaacaa cgcagccatg tggggccgac cccggctcgg
    22321 cccggtcccc gggatacgtc cgatgctctc aggggtagag cttgtcagat gatgggaggc
    22381 cggcccagtc gggtcaggcg ccataccgta cgccacttca tgggacggcg cggtccgcag
    22441 ggtgaccgcc agccttcggc gaagcccccg aaccaggcgc gcagggccgg gccggacggg
    22501 cggcgcacga gggtgagcag cagccacacc cccagataca gcggtatgag cggcagcggg
    22561 aggttgcggc gggccagcca gacccggttg cgggccacca tgcggtggta gaccgcgtgc
    22621 cggctggggg ccgtggtggg gtggaagagc accaggtcgg accggtagtc gatcatccag
    22681 ccggcgtcca gggcccgcca ggcgaggtcg gtctcctcgt gggcgtagaa gaagtcgtcc
    22741 ggcagtccgc cgacctgctg gaagacggcc gtgcggaccg cgttggcgcc gcccaggaag
    22801 gtggtcaccc gggaggagcg catcgggtcg gaggcgcgca gccgggggac gtgacggcgc
    22861 tgggtgaccc cggtgtcggg gtcggcgatc cggaagctga cgatgcccag ctccgggtcg
    22921 gcggcgaagg cccgccggca gagttcggcc gtgtcggagt tcggcagcag gccgtcgtcg
    22981 tcgaggaaga gcaggacgtc gacgtcgcgg ccgccgggcc cgaaggcctc gatgccgacg
    23041 ttgcgcccgg cggggatgcc gacgttctcg ggcagctcga tggtcctgac ggtcaggtcg
    23101 ggcaccgtca gctcgggcag cggcgagccg ttgcccacga ccacgacctc gatcgggtcg
    23161 ccgtcctgct tggcgaccga gtcgaggagc gcgcgcagct cctcggggcg gttgcccatg
    23221 gtgaggacca ccgccccgag cctcatcgcg ggggcgctca cttcagcctg ctggaggcca
    23281 ggacggacac gaggtggagc agcgtctgca gcatcgcgat gccggccagc acggcgaccc
    23341 cgagccggga gaagaacagg tcgtcccgga ccgcgtcgag gaccgccagc gccaggatca
    23401 gcagggacgc ctcgacgccg agcacgagcc ggtggaactt gagcgccgcg gccgcccggc
    23461 gggccagcgc cataccggac gagcgcggct cggacgccgc ctccttgacg ggcggcagtc
    23521 cgccctggtg gcgggcgacg ccgacgaggt ccgtctcggc cttgatcagg acggcgccga
    23581 gggcggccag ggtgccgagg aacgcccaca gccagtcgat gcgcccctcg ccccacaggt
    23641 cggcggcgcg cagcccgaag ccgacgagca cggcggcgtc gcacagatag gcgccgaccc
    23701 ggtcgaggta gaccccgccg agggagaact gcttcttcca gcgggccacc tcgccgtcga
    23761 cgcagtccag cagcaggtag agctggaccg ccagcacgcc gagcacggca ccggtgatcc
    23821 ccggcaccag cagggccggg gcggcgagga caccgaagac ggtcatcacg taggtcagct
    23881 ggttgggcgt gacccgcgtg ttcaccaggt gccggtccac gcgcagcgag agttcgcgca
    23941 tgtagagccg gccggcccag tgctcgccgc tccgccggtc cttcacgccc ggggggtgaa
    24001 cgaccgggcg gagttcagct actgatggct ttggcatagt cggcgtaagc gtccctgatc
    24061 tggtcggtgg agaggttccg gtgctccagg atcgtgtagc gcccggggcg ggtcttgggc
    24121 gcgaactcca cggccttgac gaactcctcg tcggtgaagc cgatctcgcc ggggagcacc
    24181 ggcagaccgt gccgcctcag cacctcgacc atgtgcgcgg actgctcgcg ggcgccgcgc
    24241 agatgcatcg cgaaggcggc gccgagcccg cactgctcgc cgtgggcggc ggcgcgcttg
    24301 gggtagagca ggtcgagggc gtggttgatc tcgtggcagg cgccggaggc cggccggctg
    24361 tcgccggcga ccgacatgga gatgccggtc atgaccaggc cctcggcgag cacggtgagg
    24421 aagtcgtcgt ccccgcagcc gccggggtgg cgcagcaccg cctcgccgga ctgccgggcc
    24481 atggcggcgg ccaggccgtc gatctgctcg ccggtctccc ggtgggagag ctcccagtcg
    24541 gcgacggcgg agatgttgga gatcacgtcg ccgacgccgg agcggacgaa gcggatcggg
    24601 gcctcgcgga tcacatcgag gtcgatgacg atcgcgatgg ggttgggcac cccgtaggag
    24661 ccgcggcccg cgtcgttgtc gagggtggcg accggcgagc agagaccgtc gtgcgagagg
    24721 ttcgtcgcga cggcgaccag cgggaggccg atccgcgccg cggcgaactt cgcacagtcg
    24781 atgatcttgc cgccgcccat gccgacgacc gcgtcgtagt ggccggactt catggcgtcg
    24841 gccagcttga tcgcctcgtc gagggtgccg ccgccgacct cgaaccaggc cgctccgggc
    24901 agcgccggcg cgaaccgctc gcgcagcgcc gccccggagc cgccgctgat cgcgatggcc
    24961 agcttgccgg aggcggagat ccgctggtcg acgaggagcc ccgccaggtc gtccagtgcg
    25021 ccggcgctga tgtcgacgac gaccggggac ggaatgagac gggtcagtac cggcacgcga
    25081 tctcccgtcc acgggcgagg tcgtcgtggt tgtcgatctc gacccaccgg acatcgccga
    25141 tcggggcgac gtcgatcttg aagccgcggt tgaccagctc ctggtagccg tcctcgtagt
    25201 agaggtcggg gtccttctcg aaggtggtct tcagcgcgtc ggccagctcg gcggcggcct
    25261 cggcctcgat cagggtgacg ccgatgtact cgccggtggc ctcggcgggc tccatgagct
    25321 tggtgatgcg ccggacgccc ttctcggggt ccgtgatgac cttcatctcc tcgtcggcga
    25381 gggacttcac cgtgtcgagg gcgaggatga tcttctgccc ctgcccgcgg gcggcgagca
    25441 gggtcttctc gacggagacc gggtgcacgg tgtcgccgtt ggcgaggatc acgccctggc
    25501 cgaggacgtc acgggcgcac cagagggagt aggcgttgtt ccactcctcg gccttgtcgt
    25561 tgtcgatcag ggtgatcttg acgccgtact tcttctccag ggcctcccgg cgctcgtaca
    25621 cggcctcctt gcggtagccg acgacgatgg cgacctcggt caggccgacc tcggcgaagt
    25681 tgcccaaggc gatgtcgagg acggtggtgg cctcggggtt gtccgcgggg cccaccggca
    25741 ccagagcctt gggcagggtg tcggtgtagg ggcgcagacg ccgtccggcg ccggctgcca
    25801 gcacgaggcc gatcatgcgg gttctcctgt ttcgtcgtgt acggcgggtg ctccggagga
    25861 gacccagaag cggatgctct cgatgagcac cgcgagcgcg atgaccgcgg ccagggcggt
    25921 cagcgcgatg gtgaaacctg tggcggggag gagggcggcg gcggccgtga ccgcgaggac
    25981 ccgtccctcc tgtcccccga ccgcccgtac cagccaggcc ggcggggcgc cggtgccgcc
    26041 gcggatgcgg tacaccgtgt cgtaatgatg ataggccgcg gccgccacca gcccgaacgc
    26101 cgcgggcagg gcgccgtccg tctccgcgcg ggccgccagc accaggatgg tgccgtactc
    26161 ggccgtgcgg aagagcgggg ggacgagcca gtcgagggga ccggtgaacg ggcgggcgac
    26221 ggcgaggccg gacagggccg cgtagccgag ggccgcgacg gccggccagg ggccgccgga
    26281 cggggtgaac gaggccgtga gcaggatcag cgccgtggcg agcagggccg cggcgggcgc
    26341 gccgaggagg gcgggcagcg cccgggccgg ggcccgcagg gcgcgggcgg ccgcctcggc
    26401 gagcggtccg gagtcggcga ggtcggccag ggcccgcccg gcgcgggcgg tgcgggggcc
    26461 gcggcgggcg agggagcgca gcagccgtcc ggcggtggtg tagcaggcgg cgagcgcgca
    26521 gccgacgagc aggacggtga agacggtgcg gggggtggtg agcgccgtca ggacggcgat
    26581 cagcgcccag cgctcaccga tgggcagcac gatcatgcgg cggacccaga cggtccagcc
    26641 gacgctgtcg agcctgccgg agatcgcggc ggcggggctg gtgttgccgg gggcgtcgtg
    26701 gtcggcctcg ttgaaggcga agtcgacgac gtgccgcacg gtctgcagga tcatcgccgc
    26761 cagcgcgagg gcccagacgt cgtcaccgcc ccgggccgcg ccgagcgcca ggcccgcgta
    26821 gaaggcgtac tccttggccc ggtcgaaggt ggcgtcgagc caggcgccga gcgtggagta
    26881 ctggagcgag tagcgggcga gctggccgtc ggtgcagtcg aggacgaagg agaagaggag
    26941 cagcagcccg gcggcggcga agccggggcg ggtgcccgtc gcggcgcagc cggcggcgat
    27001 cagcgcggtg atcagcgagg cggtggtgac ctggttcggc gtgaggccgc ggcgg
//
