LOCUS       NZ_CP023202            21128 bp    DNA     linear   CON 21-MAR-2024
DEFINITION  Streptomyces xinghaiensis S187 chromosome, complete genome.
ACCESSION   NZ_CP023202
VERSION     NZ_CP023202.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces xinghaiensis S187
  ORGANISM  Streptomyces xinghaiensis S187
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7137891)
  AUTHORS   Zhao,X. and Yang,T.
  TITLE     Draft genome sequence of the marine sediment-derived actinomycete
            Streptomyces xinghaiensis NRRL B24674T
  JOURNAL   J Bacteriol 193 (19), 5543 (2011)
   PUBMED   21914869
REFERENCE   2  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Genome mining of a marine derived strain Streptomyces xinghaiensis
            reveals biosynthetic ability of xiamycin analogues
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7137891)
  AUTHORS   Chen,L., Zhao,X. and Lin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
REFERENCE   4  (bases 1 to 7137891)
  AUTHORS   Zhao,X., Yang,T. and Chen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2, Dalian, Liaoning
            116024, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly :: Streptomyces xinghaiensis S187 genome
            sequencing
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000220705.2-RS_2024_03_21
            Annotation Date                   :: 03/21/2024 05:53:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,157
            CDSs (total)                      :: 6,072
            Genes (coding)                    :: 5,922
            CDSs (with protein)               :: 5,922
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 150
            CDSs (without protein)            :: 150
            Pseudo Genes (ambiguous residues) :: 0 of 150
            Pseudo Genes (frameshifted)       :: 36 of 150
            Pseudo Genes (incomplete)         :: 134 of 150
            Pseudo Genes (internal stop)      :: 6 of 150
            Pseudo Genes (multiple problems)  :: 26 of 150
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 693294
            Orig. end                         :: 714422
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023202.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Shanghai Jiaotong
            University, School of Life Science and Biotechnology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11128](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(501..514)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(1042..2010)
                     /locus_tag="SXIN_RS03025"
     CDS             complement(1042..2010)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146156.1"
                     /locus_tag="SXIN_RS03025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="WP_019706401.1"
                     /transl_table=11
                     /translation="MTEIDLRDLLSGPEADPAGRAGYTGHPERVGFFTDTSVCIGCKAC
                     EVACKEWNAIPEDGLSLTGMSYDNTQGLGGSTWRHVAFIEQSAVTRAPAPPEPAGAVTP
                     GAEVPHPDGRTELRWLMSSDVCKHCTHAACLDVCPTGSLFRTEFGTVVVQEDICNGCGY
                     CVPACPYGVIEQRPSDGRAFKCTMCYDRLGEGMEPACAKACPTDSIQFGPLDELRERAA
                     GRVEQLREAGVTDARLYGEDPEDGVGGDGAFFLLLDEPEVYGLPPDPVVTTRDLPRMWT
                     HAGVAALSLLGGIATAFLSSPAARRGAGTARTGVFGRGLGR"
     gene            complement(2007..2261)
                     /locus_tag="SXIN_RS03030"
     CDS             complement(2007..2261)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SXIN_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_095756546.1"
                     /transl_table=11
                     /translation="MGVRSRMLERPVYRQLTGKDPRGRGAAARSRHGEQLTARTATADR
                     AVGPVRPYRAVPTAPAAERRGPEHGGRAAVVTARTGARP"
     gene            complement(2423..2593)
                     /locus_tag="SXIN_RS31455"
     CDS             complement(2423..2593)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) triceptide_precursor"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947290.1"
                     /locus_tag="SXIN_RS31455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019706657.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEKKTNQLLAEPEEYPAARQKEPRNLDVWSRVAPIRLAGYDDD
                     PAESHILRGID"
     gene            complement(3103..4599)
                     /locus_tag="SXIN_RS03035"
     CDS             complement(3103..4599)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152586.1"
                     /locus_tag="SXIN_RS03035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_019707994.1"
                     /transl_table=11
                     /translation="MTVTDDGRAEQAERTEQAGQEHPGIDPERLAACLGVLAELDDLPL
                     DHPDAITVRRATAGIYRTVKQRRRQERRAAKTANDKAVTEATATGSADRIDDETAGIPL
                     AASAATEIVGILERPRSCYICKTRYREVDAFYHQLCQSCAKENRARRDARTDLTGRRAL
                     LTGGRAKIGMYIALRLLRDGAHTTITTRFPKDAARRFSAMPDSGDWLHRLKIVGIDLRD
                     PAQVVALTDAVSAEGPLDILINNAAQTVRRSPESYAELVAGETAPLPSGGGLPEPLVLG
                     SFGSGSQTALPAAADRAGGITPDSLAALALTSGSASPARIEAGNAIDAGGLIPDLADTN
                     SWIQTVSEVEPVELLEVQLCNVTAPFILVSRLRPAMAASPARRKYVVNVSAMEGVFGRG
                     YKGAGHPHTNMAKAALNMLTRTSAQEMLETDGILMTSVDTGWITDERPHPDKMRLAEAG
                     FHAPLDLVDGAARVYDPIVRGELGEDLYGCFLKDYAPSGW"
     gene            complement(4804..5766)
                     /locus_tag="SXIN_RS03040"
     CDS             complement(4804..5766)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103560.1"
                     /locus_tag="SXIN_RS03040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endo alpha-1,4 polygalactosaminidase"
                     /protein_id="WP_095756547.1"
                     /transl_table=11
                     /translation="MRDRRAGRTGGPRLRPRLRPHPRPRRSRGTGTRTRTRPHTAVLTA
                     VLLLLAGAAGCSGPGARPPADGSAPGPGSRSPSAATGGEEGAGHWRPKPGTPWQWQLSG
                     RVDTSVDVPVYDIDGFENDAETVARLHADGRKVICYINAGAWEDFRPDRDDFPRAVRGR
                     GNGWPGERWLDIRRTAVLRPLMARRMDMCRDKGFDAVEPDLMDGYLNRTGFPLTARHQL
                     AYNRMLAELAHERGLAVGLKNDLPQIPELVGSFDFAVNEECAEFGECAALTPFVEQDKA
                     VFHAEYALDPDDYCAESERLRLSSLRKNLSLDAWRRPCP"
     gene            5970..7448
                     /locus_tag="SXIN_RS03045"
     CDS             5970..7448
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142073.1"
                     /locus_tag="SXIN_RS03045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_019707993.1"
                     /sec_met_domain="Aldedh (E-value: 8.1e-144, bitscore:
                     478.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSAEPTPPAPYTGFDRMFLAGRWQPGSSGSVGTDSDPYSGETLT
                     EIQLAAPSDVDLAYGAAREAQPRWAALPEEERAAVLDRAARIMAARRAEIGGWLTREAG
                     ATAARVGMELGILEAVTRLAADHREPAPPEVPADVPGKENLIRRRPVGVVAVISPWNFP
                     AYLSNRSVAPALAAGNAVVLKPAGDTPVTGGLLLAKIYEEAGLPPGLLSVLVGSGGEIG
                     DRMVAHHVPRVVSFTGSTPVGRRIAARAGLKKLALELGGNGPMVVLDDADLDSAVDAAL
                     YGSYFHQGQICMATNRVVVDGSRFDDFAGLFTERARALRAGDPRDERTQIGPLINDSQL
                     AGVRDKVARSVTQGARVVLSGEPSGPTGRVLPPHVVIGGNDVTTAAEEVFGPVATLVRA
                     DGEEDALRLANDTEYGLSSAVFTADPERGLRFASRVEAGMTHVNDTTVHDDVRAAFGGE
                     KASGLGRFGGEWVFEEFTTPHWVTVQHAPRDLAF"
     misc_feature    complement(6014..6027)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     misc_feature    7503..7519
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     gene            7572..8387
                     /locus_tag="SXIN_RS03050"
     CDS             7572..8387
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849314.1"
                     /locus_tag="SXIN_RS03050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_039820727.1"
                     /transl_table=11
                     /translation="MGQTQEPLPKGIDINVPSVARMYDYFLGGKDNYAVDREASDELLK
                     VVPSTRELALNNRQFLARVVRRLAEDHGIRQFLDHGSGLPTQNNVHQVAQSVDPSSRVV
                     YVDNDPIVLAHGRALLEENENTAVITADMRDTDGIFGHPEVERLIDFDEPVAALFVSVL
                     HCIKDEDDPAGLIRTVRDRLAPGSFMVICQLVSEDAATRDFVTDFMDKSTHGNWGRVRR
                     QRDLEQFFEGLEILEPGLVEVSTWRPDTDLAPRQRTQEWIEYGGVGRLP"
     misc_feature    8712..8729
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.36"
                     /tool="antismash"
     gene            8995..9996
                     /locus_tag="SXIN_RS03055"
     CDS             8995..9996
                     /NRPS_PKS="Domain: oMT (117-276). E-value: 2.8e-15. Score:
                     47.2. Matches aSDomain: nrpspksdomains_SXIN_RS03055_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744116.1"
                     /locus_tag="SXIN_RS03055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_019707991.1"
                     /transl_table=11
                     /translation="MTDAADSITGTGHAPGRGGLVIDPPRPREAALGEEAFGEETPFGE
                     ETPFDEAEVPLYYSRKTADILHKYGPGPRVHFHLGMFESTPNTTVAQHLIRRRITDSQE
                     AVIRHAAATWGAADHPPASLLDIGCGLGGGSIYWAQEHGSTVTGLTITADHIPVMDHLV
                     RRAAVRDRVTPVLGDVHAFREERAYDAAVAVESAVHMDRRRLFAVAARALRPGGWFGLQ
                     DHFLCRPEVAGFVNGYYRTRLGTLDEYVRAAREAGFTLERDEDITDPVSEFWVQSMAWT
                     AAELDRTAGSAAPSPIARERLTDSAVGHGRLFRIWRDHAVETRLLLFRLRTD"
     aSDomain        9346..9822
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SXIN_RS03055_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.80E-15"
                     /label="SXIN_RS03055_oMT.1"
                     /locus_tag="SXIN_RS03055"
                     /protein_end="276"
                     /protein_start="117"
                     /score="47.2"
                     /tool="antismash"
                     /translation="DHPPASLLDIGCGLGGGSIYWAQEHGSTVTGLTITADHIPVMDHL
                     VRRAAVRDRVTPVLGDVHAFREERAYDAAVAVESAVHMDRRRLFAVAARALRPGGWFGL
                     QDHFLCRPEVAGFVNGYYRTRLGTLDEYVRAAREAGFTLERDEDITDPVSEFWVQ"
     gene            10001..11128
                     /locus_tag="SXIN_RS03060"
     CDS             10001..11128
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886333.1"
                     /locus_tag="SXIN_RS03060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_238153656.1"
                     /sec_met_domain="T1TS (E-value: 5.8e-67, bitscore: 225.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAETTTGALAAASSTAGGTPPGGLPPFWCPVESAVHPAVRRIEER
                     AVAWLDASGVFTDAADRAWNLASNAAEFSCRLAPSGDEERLLLFAQWTYWLFALDDTRL
                     DAGPSADRSPDVAGLGLRLVRSLEAPGSGMLGSGPMARALDDLVVRTRAATGPVQFQRL
                     ADGVRDLLLGAAWQQANAGRGVVPSPAEYAAGRIADVGTRFDAAFVEIAGGAGIPGDLL
                     HSGPVRALTEATGFIAACDNDLLSAAKEAGEKTAAPNLVRVLAHHHRCSERQALAAALS
                     LRDRAMTLFLRLRERTARLADEALRRYLDDLGHWIAGNIRWSDTAPRYASPRHLHPLPV
                     AGATLGVTLRQGPADARPGPPGLSTIDWWWDQLGG"
     gene            complement(11192..12613)
                     /locus_tag="SXIN_RS03065"
     CDS             complement(11192..12613)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519743.1"
                     /locus_tag="SXIN_RS03065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_238153924.1"
                     /transl_table=11
                     /translation="MIRLYGPEAETDPMGLYERLRAQYGAVAPVLLHGDLPAWLVLGYR
                     ENLDVARTPSRFSRDSRHWRLAREGRVAPDHPLAPVVAWQPMCTHVDGREHERLRGAVI
                     DGLDRFDRRGIRRTVTRSAHVLIDRFCAEGRADLVQQFSEHLPMLVMTQLLGMPESYGP
                     KLVEAARDLLKGTETAVTSNDYVLRALRQLVARRHSSPGQDFASWLIEHPAGLTDDEVV
                     QHLRVVLIAAYETTANLIINMLRMVLTDRRFRADLAGGHMTLPDAMEQVLWDEPPMMTA
                     VGRWATGDTELGGQSIRAGDLLILGLAAGNLDPAIRPDPSVPVHGNRSHLAFSGGPHEC
                     PGQDIGRAIADTGVEALLARLPDLRLAVDETELSWVSALMTRHLTALPVEFTPQRPEPK
                     EPSLSVAVPAPSGRAPLPGEAAMGDGTGYAAARQRTAVPVLAGVADPLAAGTGPSPLRA
                     SAPWWRRLARWFAGR"
     misc_feature    12600..12613
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            complement(12757..13380)
                     /locus_tag="SXIN_RS03070"
     CDS             complement(12757..13380)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056720.1"
                     /locus_tag="SXIN_RS03070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_019707989.1"
                     /transl_table=11
                     /translation="MDYRTSDTLPGPRSEDALPATAASAVKVVIVGGFGVGKTTLVGSV
                     SEIRPLTTEETMTQAGVGVDDIAGVERKTETTVAMDFGRISINEQLVLYLFGTPGQERF
                     WFLWNGLFEGALGALVLIDTRRLEVSFDVVGRLEERGVPFVVVVNDFPESPRYPVSELR
                     AAMDLPDSVPMVTCDARDRGSCRDALLTLMRYLHTLATATPESL"
     gene            complement(13361..13723)
                     /locus_tag="SXIN_RS03075"
     CDS             complement(13361..13723)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846603.1"
                     /locus_tag="SXIN_RS03075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_019707988.1"
                     /transl_table=11
                     /translation="MSGPGEDWEEGAPERLYVLTGGRGRARGRTADLDLVTLIVSRDVP
                     KPGMQPEHAAMLRMCHYPLSVAEISAHLVLPVSTVTALLTDLLADGRMEARAPIPTAAL
                     PDADLLKAVMHGLQNL"
     gene            complement(13720..14127)
                     /locus_tag="SXIN_RS03080"
     CDS             complement(13720..14127)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056718.1"
                     /locus_tag="SXIN_RS03080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_019707987.1"
                     /transl_table=11
                     /translation="MTQQRLNMDWMLRDLATSVPQTRHIVVLSADGLCMAQHGTDGDTA
                     DRLAAACAGLQSLSGAIAAEFPHGSGQMRLVVIEVSGGFFYLMAAGAGAYLAVLADDGV
                     DAGLMGQRMRDLVARIGEHLSSPPRVDEQIT"
     gene            complement(14132..15625)
                     /locus_tag="SXIN_RS03085"
     CDS             complement(14132..15625)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467910.1"
                     /locus_tag="SXIN_RS03085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_095756548.1"
                     /transl_table=11
                     /translation="MVRAGSSPGGRRPASALLWLFPPAVTALCAVVAVLGVPGGARAPV
                     AWCGAVATAAVAIAAAEAVRRGRLIHALRRRAAEQEAALGRRLAQQEAETERLAGELLP
                     VAVERLQRGASVEEVLEGVAYAPGADPRFHAAHEAVLRSVLEAVRAEEDLRESAHRAFV
                     NIARRVQAIVHQQAQDLREMEDRHGNEPEFFGDLLHLDHGTALIGRLADSIAVLGGSRP
                     GRQWQQNVPLFNVLRGAMSRIIDYQRVDLHSVAEAAIVGPAVESLIHALAELLDNATRY
                     SPPQTRVHLTAVEVQSGIAVEIEDAGVGLTEEARRRAERVLAQASAGIDLNDLGETPRL
                     GLAVVGRLAQTHDFQVSLRPSAYGGVRCVLIVPQDLITATPTPGGSVARAATLPPPKRR
                     TRPTPTPLPRPNGAAMEEDPAAVGRNANGLPQRRRRHPGVAPRAAAPARSAAPPRPPAA
                     AEQVKPGLWLAAFQSGINGEAPAPRAARPNSDDSVDRDE"
     misc_feature    15826..15840
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.55"
                     /tool="antismash"
     misc_feature    complement(15864..15873)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.65"
                     /tool="antismash"
     gene            16085..17737
                     /locus_tag="SXIN_RS03090"
     CDS             16085..17737
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018381579.1"
                     /locus_tag="SXIN_RS03090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_238153657.1"
                     /transl_table=11
                     /translation="MQPPPVTGTRDERPRRPRRTPGRIPWRRPRRAPRGAPADGAVPGA
                     ARPGTAVSGSTGAGWTARAVPYGPAAVAVLFTLAQLVLVVPGTGLGWDETVYVSQVSSH
                     APAAFFSAPRARGITYLAAPVAALTDAVPPLRVWLALLSGAGLFLALRVWRDLLPAAVL
                     TLAGGLFAGLWVTLFYGPLVMPNLWVALAALFTTGCLLRAVRNPSSRWAPAGVCAGVAL
                     VALMRPSDALWLALPLGAALLLVRSWRRPLLLAALVAGGALGSAEWIAEAYSAYGGLAA
                     RLSRASEIQGHLAPYFSVDDHIRALGGRTLCRPCDVPWRNPGTGVWWFALPLLAGGGAL
                     AARRTRHRAEILLPALTGLVLALPYLFLVGYAAPRFLLPAYALLSLPVAHGLFRLVRWV
                     REARPGLRPAAAALSVTVLGLHLGVQFTVLHSTVSSFRVNGERLDRMAAELGRQGVRPP
                     CVVSGPDAVRIAFRAGCSSRQVGGHDGSITHAALRATAETRPVAVLVTNGADPPPYARA
                     WRSRPLPDFGPWRFRAYLSPAARPDTGPVTARD"
     gene            complement(17831..18568)
                     /locus_tag="SXIN_RS03095"
     CDS             complement(17831..18568)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644132.1"
                     /locus_tag="SXIN_RS03095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_095756549.1"
                     /transl_table=11
                     /translation="MFKHAQILTDMTPLRRRAAFMAAGVGATAVLGTGVALGTQGETEN
                     PATGTTASEAADSRAASEAVTAQAEAQKKAAEGKAAAEAAAAERAGQEAADRSKRETVT
                     QAAAKAPASWVKPVDSYVKGSTFGIGGDRWANKHSGQDFAAPTGTSVKTVHEGTVVQAG
                     WGGSYGNNIVVKHDAGTFTQYAHLSKITVPVGTQVTTGQEIGKVGSTGNSTGPHLHFET
                     RTTPNYGSGIDPVAFLKQRGVTL"
     misc_feature    complement(20697..20712)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    complement(20979..20994)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.31"
                     /tool="antismash"
ORIGIN
        1 gttcccgctg cgggacgacg gtgtacgcgg ggtcctccgc cgaggcgatg cccgcgtgga
       61 acaccccgaa gcgggtgcag gccgagccgg cgagcagcgc gaggccgctc acggccgccc
      121 cgctccggta ccgccggccg agcaccgcgg cgcccagcgc cccgcccgcg gtgaggagtt
      181 cggcggcccg catgagcttt ccggccttcc cccgttcgta ggtctcggcg atcatgccga
      241 gccggcggcg cttcagccgc acggccgcgg cctcgcccgc ggcggcgagc agggccgcgc
      301 gccgcgccgg ggcgttctcc cggaccgggg cggtgaccag ggccatgccg gaggcggcgg
      361 ccgtcgccga ggagacgaag aggtacggca gttcgcggtg ggcctcgtgc caggcgggga
      421 cggcggtgtc ggcggccagt accgcggtgt acgcggcgac gacgggcccg agcagcgccg
      481 cggtgccggt ggccgccgtg ttgatccgcg gcagccgccc ggtggtctcc aggacggcgg
      541 cggcgccggc ggcgggcccg taggcggcga gcagccagga gccgacgctc atcggggagg
      601 tcggtttgaa cacgcggagc atgttggcga accgctccgg ccggccgagg tcgtggatga
      661 gggcggcggt ggaggccgtg acggccgcca gcgaggagag cttcatcgcc ttcgcggtgg
      721 tggggcgccc gctgagctgg gccccggcgg ccagtacgga gccggccccg gcgagcccgc
      781 cggcgaagaa gtagccggcg atgtccgtgg ccttccagcc cggtgccttg atgacgggac
      841 ggccgtagta ggacccgaac tcggcgcggg gcaccatggg ttcctcgccg cgccgtttgc
      901 cgcggcgccg tttccggtcc gtcttcccgg ccgccgggcc ggagcgctcc gccgaggtgc
      961 cgccgggccc cgggccggcc ggggtggcct cgcgccccgc gcgctcgccc cggacgccgt
     1021 ccttcgtgac gtcggagtcc gtcatcggcc cagtcccctt ccgaagacgc cggtacgagc
     1081 ggtgcccgcg ccccggcgcg cggccgggga ggacaggaag gcggtggcga tcccgccgag
     1141 gagggagagc gcggccacac ccgcgtgggt ccacatccgc ggcaggtcgc gggtggtgac
     1201 gaccgggtcc ggtggcaggc cgtagacctc gggctcgtcg aggaggagga agaacgcgcc
     1261 gtcaccgccg accccgtcct ccgggtcctc tccgtacagg cgggcgtccg tgacgccggc
     1321 ctcgcgcagc tgttccaccc gcccggcggc ccgctcgcgg agttcgtcca gcgggccgaa
     1381 ctggatcgag tcggtggggc aggccttggc gcaggccggt tccatgccct cgccgagccg
     1441 gtcgtagcac atcgtgcact tgaacgcccg gccgtcgctc ggccgttgct cgatgacccc
     1501 gtacgggcag gcgggcacgc agtagccgca gccgttgcag atgtcctcct gcacgaccac
     1561 ggtgccgaac tcggtgcgga agagcgagcc ggtcgggcag acgtcgaggc aggcggcgtg
     1621 cgtgcagtgc ttgcagacat cggaggacat cagccagcgc agctcggtcc ggccgtcggg
     1681 gtgcggcacc tcggccccgg gcgtcacggc gccggcgggc tcagggggcg cgggggcgcg
     1741 ggtgacggcg ctctgctcga tgaaggcgac gtgccgccag gtggagccgc ccagcccctg
     1801 ggtgttgtcg taggacatcc cggtcagcga caggccgtcc tcggggatgg cgttccactc
     1861 cttgcacgcc acctcgcagg ccttgcagcc gatgcagacg gaggtgtcgg tgaagaagcc
     1921 gacccgctcg gggtggccgg tgtacccggc cctgccggcc gggtcggcct ccggcccgga
     1981 gagcaggtcc ctcaggtcga tctcggtcat ggccgggccc ccgtacgggc ggtgacgacg
     2041 gcggcacggc cgccgtgctc cgggccgcgg cgctcggcgg cgggggcggt cgggaccgcg
     2101 cggtacgggc ggaccggccc gacggcccgg tccgccgtgg cggtccgggc cgtcagctgt
     2161 tcgccgtgcc gggatctcgc ggccgcgccg cgcccccgtg ggtcctttcc ggtgagttgc
     2221 cggtacaccg gccgttcgag catccggctg cgcacgccca tccgttcctc cgccgtccgc
     2281 cgttactgcg ctgcagatcc gctgagctga tcatcgggac gggcctcggg tgcccccgga
     2341 accgggcgcg aaacgcgagg acccgccggg cggggtgctc ccggcgggtc gtcaggtggc
     2401 cgtacgggga cggcctgcgg cgtcagtcga tgccgcggag gatgtgggat tcggccgggt
     2461 cgtcgtcgta gccggcgagc cggatggggg cgaccctgga ccacacgtcc agattgcggg
     2521 gctccttctg gcgggcggcc gggtactcct cgggttccgc cagaagctgg ttggtcttct
     2581 tctcggttgt caccgcgcac tccttagtgt cgggtgcacc ggacgccgta tgcccgggaa
     2641 actgcgcagc cggaggcacg tggccgggcg ccgacgcccg atggggctag tggtaagtca
     2701 ctgcgggcgc ggtggcgccg gagatgcgga ccgggagtgc ggccatggtg gctggcctgt
     2761 cccgggacgg gccgagggtc tcggtgcttc atttaccgga aggctgtccg tctgctgtcc
     2821 accctacccc cacctgcgcg gaagcgctcg cggatatcag gatccggata ccggagacgg
     2881 ccggggcggc ccggcgcccg tgcggcggga cgccgggcgg acggggaatc cggacggcgc
     2941 ggggagcgcc ggatggcccg gtcggccgcc cggctccacc cctccgggtg agggcgcggg
     3001 gaggaggccg ggggccgggg gcgcggggac tcggggggcg cgagggcgcg gggtacgcgg
     3061 ggcgcggggt acgcgggaac gtccccggcc gccggccccg gctcaccagc cggagggcgc
     3121 gtagtccttc aggaagcagc cgtacagatc ctcccccagt tcaccgcgga cgatggggtc
     3181 gtagacccgg gccgcgccgt cgacgaggtc cagcggggcg tggaagccgg cctcggccag
     3241 ccgcatcttg tccgggtgcg ggcgctcgtc ggtgatccag ccggtgtcga cgctcgtcat
     3301 gaggatgccg tcggtctcca gcatctcctg ggcgctggta cgggtgagca tgttcagcgc
     3361 ggccttcgcc atattggtgt gcggatgtcc ggcgcccttg tagccccggc cgaacacccc
     3421 ttccatggcg gagacgttca ccacgtactt gcggcgcgcg ggggaggcgg ccatcgccgg
     3481 gcgcagccgg ctgaccagga tgaacggcgc ggtgacattg cagagctgca cctcgagcag
     3541 ctcgaccggc tccacttcgc tcaccgtctg gatccagctg ttggtgtcgg cgaggtccgg
     3601 gatgagcccg cccgcgtcga tggcgttgcc ggcctcgatc cgcgcgggtg aggcggagcc
     3661 gctggtcagc gccagggcgg cgagggagtc cggggtgatg ccgccggccc ggtccgccgc
     3721 ggcgggcagc gccgtctggc tgccgctgcc gaaactgccg aggacgaggg gctccgggag
     3781 accgccgccg gacggcagcg gcgcggtctc gccggccacc agttcggcgt aggactccgg
     3841 ggagcggcgc acggtctggg cggcgttgtt gatgaggatg tccagcgggc cctcggcgct
     3901 caccgcgtcc gtcagcgcca ccacctgcgc cgggtcgcgc agatcgatcc cgacgatctt
     3961 gagccggtgg agccagtccc cgctgtcggg catcgccgag aagcggcggg cggcgtcctt
     4021 ggggaaacgg gtggtgatgg tggtgtgcgc gccgtcgcgc agcagccgca gcgcgatgta
     4081 catgccgatc ttggcgcggc cgccggtgag cagggcgcgc cgccccgtca gatccgtccg
     4141 ggcgtcgcgg cgggcgcggt tctccttggc gcaggactgg cagagctggt ggtagaaggc
     4201 gtccacctcg cggtaccggg tcttgcagat gtagcaggag cgggggcgtt ccaggatgcc
     4261 gacgatctcc gtggccgcgg aggcggcgag ggggatgccg gccgtctcgt cgtcgatgcg
     4321 gtcggcggat ccggtggcgg tggcctcggt gacggccttg tcgttggccg tcttggcggc
     4381 ccggcgctcc tggcggcggc gctgcttcac cgtgcggtag atccccgcgg tggcgcgccg
     4441 caccgtgatg gcgtcgggat ggtccagcgg caggtcgtcg agttccgcga gcacgccgag
     4501 acacgcggcc agccgctccg ggtcgatgcc ggggtgctcc tgcccggcct gctcggtccg
     4561 ctccgcctgc tcggcccggc cgtcgtctgt caccgtcatc gccgctgccg cttccgttcc
     4621 cgctccggtg cgtccgggtg cgcacactcc ggcggcactt tacggagcac ccggcggctc
     4681 cgccaaaccg ggccgggccc gcgggaggaa cgtcacaccg gcccctccgg ggcacggggc
     4741 cgggcggtcg cggggcgggt ccgggcgccg cgggcggcgc cggggccggg agcggggccc
     4801 gggtcacggg caggggcggc gccaggcgtc cagggagagg ttcttccgga gggagctcag
     4861 ccgcagccgc tcgctctcgg cgcagtagtc gtccgggtcc agcgcgtact cggcgtggaa
     4921 gaccgccttg tcctgctcga cgaagggggt gagcgcggcg cactcgccga actccgcgca
     4981 ctcctcgttc accgcgaagt cgaaggagcc gacgagctcg gggatctgcg ggaggtcgtt
     5041 cttgagcccc acggccaggc cgcgctcatg ggcgagctcc gccagcatcc ggttgtaggc
     5101 gagctggtgg cgggcggtga gggggaagcc ggtgcggttg aggtagccgt ccatgaggtc
     5161 gggctccacc gcgtcgaagc ccttgtcccg gcacatgtcc atgcggcggg ccatcagcgg
     5221 gcgcagcacg gcggtccgcc ggatgtccag ccagcgctcc cccggccagc cgttgccgcg
     5281 gccccgtacc gcgcggggga agtcgtcgcg gtcgggacgg aagtcctccc aggcgcccgc
     5341 gttgatgtaa cagatgacct tgcggccgtc ggcgtgcagc cgggcgacgg tctccgcgtc
     5401 gttctcgaag ccgtcgatgt cgtagacggg gacgtcgacg ctcgtgtcga cccgcccgct
     5461 gagctgccac tgccagggcg tgccgggctt cggccgccag tgccccgccc cctcctcgcc
     5521 gccggtggcg gcggacgggg agcgggagcc ggggcccggt gcggagccgt cggccggcgg
     5581 ccgcgccccc gggccggagc agcccgccgc tccggccagc aggagcagga cggcggtgag
     5641 gacggcggtg tgcggacggg tgcgggtgcg ggtgcccgtg ccgcggctcc ggcggggacg
     5701 cgggtgcggg cgaaggcgcg ggcggaggcg cgggccgccg gtccggccgg cgcggcggtc
     5761 tctcatggct ggtcggcctc ctcggttccc cgtcgggccg cccagtcttc cgggtcgccg
     5821 ccgtcccgtg cgacgggctg cggacggggc cggggttggc atccggcttc cggggcaccc
     5881 gggcacggtc ccggcgggca cccggtgcgc gccggaagga ccctgcacgc ttccccggca
     5941 cctgcctgca cgaccgagcg gagagagcca tgccgtccgc ggagcccaca ccccccgccc
     6001 cgtacaccgg attcgaccgc atgttcctgg cgggccgctg gcagcccggc agttccggca
     6061 gtgtggggac ggactcggac ccgtactccg gtgagacgct gaccgagatc cagctcgcgg
     6121 ccccgtccga cgtggatctg gcctacggcg cggcgcggga ggcgcagccc cgctgggcgg
     6181 ccctgccgga ggaggagcgg gccgccgtcc tggaccgggc ggcgaggatc atggcggcgc
     6241 ggcgggcgga gatcggcggc tggctgaccc gggaggcggg ggccaccgcc gcccgggtcg
     6301 gcatggagct cggcatcctc gaagccgtga cgcggctcgc ggccgaccac cgggagcccg
     6361 cgccgccgga ggtgccggcg gacgtcccgg gcaaggagaa cctgatccgc cggcggcccg
     6421 tgggggtcgt cgcggtgatc agcccgtgga acttcccggc ctatctctcc aaccgctcgg
     6481 tggctcccgc gctcgcggcg ggcaacgccg tcgtcctcaa accggccgga gacaccccgg
     6541 tcaccggtgg tctgctgctg gcgaagatct acgaggaggc cggacttccg ccgggcctgc
     6601 tcagcgtgct cgtgggcagc ggcggtgaga tcggcgaccg gatggtggcg caccatgtgc
     6661 cgcgggtggt gtcgttcacc ggttcgacgc cggtggggcg gcgcatcgcg gcccgggcgg
     6721 ggctgaagaa gctcgccctg gagctgggcg gcaacggtcc catggtcgtc ctcgacgacg
     6781 ccgatctgga ctcagcggtg gacgccgccc tctacggcag ctacttccac caggggcaga
     6841 tctgcatggc caccaaccgc gtcgtcgtcg acgggtcccg cttcgacgac ttcgccggtc
     6901 tcttcaccga gcgggcccgc gccctgcgcg ccggggaccc gcgcgacgag cggacgcaga
     6961 tcggcccgct catcaacgac tcccagctgg cgggtgtgcg cgacaaggtg gcccgctccg
     7021 tcacgcaggg cgcccgggtg gtcctctccg gcgagccctc gggccccacc gggcgggtgc
     7081 tgccgccgca tgtggtgatc ggcggcaatg acgtcaccac cgccgccgag gaggtgttcg
     7141 gcccggtggc cacgctggtg cgggcggacg gcgaggagga cgccctgcgg ctggccaatg
     7201 acaccgagta cggcctgtcg agcgcggtgt tcaccgccga cccggagcgg ggcctgcggt
     7261 tcgcctcccg cgtcgaggcc ggcatgacgc acgtcaacga caccaccgtg cacgacgacg
     7321 tccgcgcggc cttcggtggc gagaaggcgt ccgggctggg gcggttcggc ggcgagtggg
     7381 tcttcgagga gttcaccacc ccgcactggg tgacggtcca gcacgccccg cgcgacctgg
     7441 cgttctgacc cgccgcccca acgggtttgc ccggtaaggg cgttggcctt aaccggaagg
     7501 atgtacccct ctaggatgtg agcgcgtcgc accgcacacg cgatcgcgcg gacgagactg
     7561 tgaggggtcg gatgggccag acacaagagc cgctgcccaa ggggatcgac atcaacgttc
     7621 ccagtgtggc tcggatgtac gactacttcc tcgggggcaa ggacaactac gccgtcgacc
     7681 gggaagcctc cgacgagctg ctgaaggtgg tcccgagcac cagggaactg gcgctcaaca
     7741 accggcagtt cctggcccgt gtggtccggc ggctggccga ggaccacggc atccgccagt
     7801 tcctggacca cggttccggc ctgcccaccc agaacaacgt ccaccaggtc gcccagagcg
     7861 tggacccgtc ctcgcgcgtc gtctacgtcg acaacgaccc gatcgtcctc gcccacggcc
     7921 gcgcactgct ggaggagaac gagaacaccg ccgtcatcac ggcggacatg cgcgacaccg
     7981 acgggatctt cggccacccc gaggtcgagc ggctgatcga cttcgacgag ccggtggccg
     8041 cgctgttcgt ctcggtgctg cactgcatca aggacgagga cgacccggcc ggcctcatcc
     8101 ggaccgtcag ggaccggctg gcgcccggca gtttcatggt gatctgccag ctggtgagcg
     8161 aggacgccgc cacccgcgat ttcgtcaccg acttcatgga caagagcacc cacggcaact
     8221 ggggccgggt gcggcggcag cgggacctgg agcagttctt cgagggcctg gagatcctgg
     8281 agccgggcct ggtggaggtc tccacctggc ggccggacac cgacctcgcc ccccggcagc
     8341 gcacccagga gtggatcgaa tacgggggcg tgggccggct gccctgagcc gggccggcca
     8401 cgccgccacc ccgctcggca ggagcggttg accagcaggg cccgtcccgc acggtggaca
     8461 cccaccggcc ggggcgggcc tttcgctgtc cgttcgtgat ccgcccgtgt ccgcctgtgt
     8521 ccgcccgtgc ccgctgcctc cccgccgcac gccggaggtc cgcggagcct tttcccgccg
     8581 attttccggc gggcgcgctt gttcacggga aacccgggaa accgggaaag gcgcacgtcc
     8641 gccggcggcg gcgggacggg cccaacagga ccgtcgaata ccggacatga ccgccgctga
     8701 tccgcggccg ttctcccgga gagcggatgc cgtcataaag tcctctattc actcatgcat
     8761 ccccctacgg aattcctcga ttcagcgtct tccgttcaga agcgagcatg agcagtccat
     8821 tccgacccat tgcctgtcga atgcggtagg cgcgatcgca tcgcccgggc gcgcggccgg
     8881 ggttaaggat ctccgcgacc ggggcaggtt gggggcgccg tgcgccgggc ggcgccggac
     8941 accccctccc ccacgccctg gacgactcct cagccctgcc acaggaggcc gaatatgaca
     9001 gacgcagccg acagcatcac gggcaccggt catgcccccg gccgcggcgg tctcgtcatc
     9061 gatccgccga gaccccggga agccgcactc ggcgaggagg cgttcggtga ggaaaccccg
     9121 ttcggggagg aaaccccgtt cgacgaggcc gaggtgcccc tgtactactc ccggaagacc
     9181 gccgacatcc tgcacaagta cggccccggg ccccgcgtcc acttccatct gggcatgttc
     9241 gagtccacac cgaacaccac cgtcgcccag cacctcatcc gccgccggat caccgactcc
     9301 caggaagcgg tgatccgcca cgcggccgcc acctggggcg ccgcggacca cccgccggcc
     9361 agcctcctcg acatcggctg cggcctcggg ggcgggtcga tctactgggc ccaggagcac
     9421 ggcagcaccg tgacggggct caccatcacg gccgaccaca taccggtcat ggaccacctg
     9481 gtccgccggg ccgcggtccg cgaccgcgtc acccccgtcc tgggtgatgt ccacgcgttc
     9541 cgggaggagc gggcttacga cgccgccgtg gccgtggaga gcgccgtgca catggaccgg
     9601 cggcggctct tcgccgtggc cgcccgggcc ctgcggcccg gtggctggtt cggtctccag
     9661 gatcacttcc tgtgccggcc ggaggtcgcc ggcttcgtga acggctacta ccggacgcgg
     9721 ctgggcaccc tcgacgagta cgtccgcgcc gcacgcgagg cggggttcac cctggaacgg
     9781 gacgaggaca tcaccgaccc cgtctcggag ttctgggtgc agtccatggc atggaccgcc
     9841 gcggaactgg accggacggc ggggtcggcc gcgccctccc ccatcgcccg cgagcggctg
     9901 acggactcgg ccgtcgggca cggcaggctg ttccggatct ggcgcgacca cgccgtcgag
     9961 acccggctgc tcctcttccg cctccggacg gactgagccg gtggcggaga cgaccaccgg
    10021 cgccctcgcg gccgcgtcct ccaccgccgg gggaacgcct ccgggcggac tgccgccctt
    10081 ctggtgtccc gtggaatcgg ccgtccaccc cgcggtccgc aggatcgagg agcgggccgt
    10141 cgcctggctc gacgcgagcg gtgtcttcac cgacgcggcc gaccgggcct ggaacctggc
    10201 cagcaacgcc gcggagttca gctgccgcct cgcccccagc ggggacgagg aacgcctgct
    10261 gctgttcgcc cagtggacgt actggctgtt cgctctcgac gacacccggc tcgacgccgg
    10321 gccgtcggcg gaccggagcc cggacgtcgc cggcctcggt ctgcggctgg tccgctccct
    10381 ggaggccccc ggctccggga tgctcggctc cggcccgatg gcccgcgcgc tcgacgacct
    10441 ggtcgtccgc acccgggccg cgaccgggcc cgtacagttc cagcggctgg ccgacggggt
    10501 ccgcgatctg ctgctgggcg cggcctggca gcaggccaac gccggccgcg gtgtcgtgcc
    10561 gagccccgcc gagtacgccg ccgggcgcat cgcggacgtc ggaacccggt tcgacgccgc
    10621 cttcgtcgag atcgcgggcg gtgccgggat ccccggcgac ctgctccact ccggtcccgt
    10681 ccgcgccctg accgaggcca ccggtttcat cgcggcctgc gacaacgatc tgctctccgc
    10741 ggccaaggag gccggggaga agaccgccgc cccgaacctc gtgcgggtcc tcgcccatca
    10801 ccaccgctgc tcggagcggc aggccctcgc cgccgcgctc tccctgcggg accgggcgat
    10861 gaccctcttc ctccgtctgc gcgagcggac cgcgcggttg gccgacgagg ccctccgccg
    10921 ctatctcgac gacctgggcc actggatcgc ggggaacatc cgctggtccg acaccgcccc
    10981 gcgctacgcc agcccgcgtc atctccaccc cctgcccgtg gccggggcga cgctgggggt
    11041 caccctgcgc cagggcccgg ccgacgcgcg gccgggccca ccggggctgt ccaccatcga
    11101 ctggtggtgg gaccaactcg gtggctgacg cgcggcccgg gccgcgcgcc cccgcctgcc
    11161 gacaacccgg gcacgcggac accgggacgc ctcaccggcc ggcgaaccac cgcgccagcc
    11221 gccgccacca cggggcggac gcccgcagag gggacgggcc ggtcccggcg gccaggggat
    11281 cggcgacccc cgcgaggacc gggaccgccg tccgctgccg cgccgccgcg tacccggttc
    11341 cgtcccccat cgcggcctct ccgggcagcg gcgcccgccc ggagggcgcc ggtacggcca
    11401 cggacaggga cggctccttc ggctcgggcc gctgcggagt gaactcgacc ggcagggcgg
    11461 tgaggtgacg tgtcatcagc gccgataccc agctcagctc cgtctcgtcc acggccagcc
    11521 gcagatccgg gaggcgtgcc agcagggcct cgacgccggt gtccgcgatg gcccggccga
    11581 tgtcctggcc ggggcattcg tgcgggccgc cgctgaaggc caggtgtgag cggttcccgt
    11641 ggacggggac gctggggtcc gggcggatgg ccgggtcgag attgcccgcg gccagcccga
    11701 ggatcagcag gtcaccggcg cggatggact gcccgccgag ttccgtgtcc ccggtggccc
    11761 accgccccac ggccgtcatc atcggcggtt cgtcccacag cacctgttcc atggcgtcgg
    11821 gaagcgtcat gtggccgccg gccagatcgg cgcggaaacg gcggtcggtg agaaccatcc
    11881 gcagcatgtt gatgatcagg ttcgccgtgg tctcgtaggc cgcgatgagg accacccgca
    11941 ggtgctgtac cacctcgtcg tcggtcagcc cggcgggatg ctcgatcagc caacttgcga
    12001 agtcctggcc cggcgaggag tgtctgcgcg ccaccaactg gcgcagggcg cgcaggacgt
    12061 agtcgttgct ggtgaccgcg gtctccgtgc ccttcagcag gtcacgtgcc gcctccacca
    12121 gcttgggacc gtaggactcc ggcatgccca ggagctgcgt catcaccagc atgggcaggt
    12181 gctcggagaa ctgctggacc aggtccgccc ggccctcggc gcagaaccgg tcgatgagta
    12241 cgtgcgcgga gcgggtgacg gtgcggcgga tgccccggcg gtcgaagcgg tcgaggccgt
    12301 cgatgacggc gccgcggagc cgttcgtgct cccggccgtc gacatgggtg cacatcggct
    12361 gccacgccac gacgggggcc aaggggtggt ccggggcgac gcggccctcc cgcgcgaggc
    12421 gccagtggcg ggagtcgcgg gagaagcggg acggggtgcg ggccacgtcg aggttctcgc
    12481 ggtagccgag gaccagccag gccgggaggt cgccgtggag caggaccggg gcgacggccc
    12541 cgtactgggc gcgcagccgt tcgtagaggc ccatcgggtc ggtctcggcc tcgggcccgt
    12601 agagccggat caggccgccg ggcccgtagg cgtgggccgg gcagccgggc ggcggcgcgg
    12661 actcggcggc gggatcggcg gcggaggggc ccgcggcggt ggcggtacgg gcgccggttc
    12721 ggcgccgggg gccggcgggg ccgggtggcg gaacggtcac agggactccg gggttgcggt
    12781 ggcgagggtg tgcagatagc gcatgagcgt cagcagggcg tcccggcagg agccgcggtc
    12841 gcgggcgtcg caggtgacca tcggcacgga atcgggcagg tccatcgccg cgcgcagctc
    12901 ggacaccggg taacggggcg actcggggaa gtcgttgacg acgaccacga aggggacgcc
    12961 gcgctcctcc agccggccga cgacgtcgaa gctgacctcc aggcggcggg tgtcgatgag
    13021 gacgagcgcg cccagggccc cttcgaagag gccgttccag aggaaccaga agcgctcctg
    13081 gccgggggtg ccgaagaggt acagcaccag ttgctcgttg atgctgatcc ggccgaagtc
    13141 catggcgacg gtggtctcgg tcttccgctc gacaccggcg atgtcgtcga cgccgacccc
    13201 ggcctgggtc atcgtctcct cggtggtgag cgggcgtatc tcgctgaccg agccgaccag
    13261 ggtggtcttg ccgacgccga agccgccgac gatgaccacc ttgaccgcgg acgcggccgt
    13321 ggcggggagg gcgtcctcgc tgcgcgggcc ggggagcgtg tcagaggttc tgtagtccat
    13381 gcatcaccgc cttgaggagg tccgcgtcgg gcaacgcggc ggtggggatc ggggcgcggg
    13441 cctccatgcg gccgtctgcc agcaggtcgg tgaggagcgc ggtgacggtg ctgacgggca
    13501 gcaccagatg ggcggagatc tcggccaccg agagcgggta gtggcacatc cgcagcatgg
    13561 ccgcgtgctc gggctgcatg cccggcttcg gcacgtcccg ggacacgatg agggtgacca
    13621 gatcgaggtc ggccgtcctg ccgcgggccc ggccgcggcc gccggtgagt acgtacagcc
    13681 gctcgggggc gccttcctcc cagtcctcgc cgggcccgct catgtgatct gctcgtccac
    13741 gcgcggcggg ctgctgagat gctcgccgat tctggcgacc aggtcgcgca tgcgctgccc
    13801 catcagcccg gcgtcgacgc cgtcgtcggc cagcacggcc agataggcgc cggcaccggc
    13861 ggccatgagg tagaagaagc cgccgctgac ctcgatgacg accagtctca tctgcccgct
    13921 cccgtgcggg aattcggccg cgatcgcgcc ggacaggctc tgcagtccgg cgcaggcggc
    13981 ggcgagccgg tcggcggtgt cgccgtcggt gccgtgctgg gccatgcaga ggccgtccgc
    14041 ggagagcacc acgatgtgcc gggtctgcgg gacgctcgtg gcgaggtccc tgagcatcca
    14101 gtccatgttg agccgctgct gtgtcacgtt tctactcatc cctgtccacc gagtcgtcac
    14161 tgttcggacg cgcggcccgc ggcgccggcg cctctccgtt gatgccgctc tggaaggcgg
    14221 ccagccacag gcccggcttg acctgctccg ctgccgcggg cggccggggc ggagcggctg
    14281 accgggcggg cgccgcggcc cggggggcga caccggggtg ccggcggcgg cgctgcggca
    14341 gcccgttggc gttgcggccg accgccgcgg ggtcctcctc catggccgct ccgttcggcc
    14401 ggggcagcgg cgtcggcgtg ggccgcgtcc tgcgcttggg cggcggaagg gtggcggcac
    14461 gggcgacgga gccgccgggg gtgggcgtgg ccgtgatgag gtcctgcggg acgatcagga
    14521 cgcagcggac gcccccgtag gccgaggggc gcagcgacac ctggaagtcg tgggtctgcg
    14581 ccagccggcc caccacggcg aggcccagcc ggggggtttc accgaggtcg ttgaggtcga
    14641 tgccggcgga cgcctgggcc aggacgcgtt cggcgcggcg gcgggcctcc tcggtgaggc
    14701 cgacgccggc gtcctcgatc tcgacggcga tgccggactg cacctcgacg gcggtgaggt
    14761 ggacccgggt ctgcgggggc gagtagcggg tggcgttgtc cagcagctcg gccagggcgt
    14821 ggatgaggga ctcgacggcg ggtccgacga tggcggcctc ggcgacggag tgcaggtcga
    14881 cccgctggta gtcgatgatg cgggacatgg cgccgcgcag gacgttgaag agcggtacgt
    14941 tctgctgcca ctggcggccg ggacgtgagc cgccgaggac ggcgatgctg tcggcgagcc
    15001 ggccgatgag ggcggtgccg tggtcgaggt ggaggaggtc gccgaagaac tccggttcgt
    15061 tgccgtgccg gtcctccatc tcccgcaggt cctgggcctg ctggtggacg atcgcctgga
    15121 cgcggcgggc gatgttgacg aaggcgcggt gggcggattc gcgcaggtcc tcctcggcgc
    15181 ggaccgcttc gaggaccgaa cggagcaccg cctcgtgggc ggcgtggaac cgggggtcgg
    15241 cgccgggtgc gtaggcgacg ccctccagca cctcctcgac ggaggctccg cgctggaggc
    15301 gctcgacggc cacgggcagc agttccccgg cgagccgttc ggtctcggcc tcctgttggg
    15361 cgaggcggcg gccgagcgcg gcctcctgtt cggcggcgcg ccgccgcagt gcgtggatca
    15421 ggcgtccgcg ccgtaccgcc tcggccgcgg cgatcgccac ggcggcggtg gcgacggcgc
    15481 cgcaccaggc gaccggggcg cgggccccgc cggggacgcc gaggacggcg acgaccgcgc
    15541 agagagccgt cacggcgggt gggaacagcc acaggagcgc ggaggcgggc cgccgacctc
    15601 ctggtgacga gccggcacga accatcaatg tctcaaaccc ttgcggaagg aataggggtg
    15661 tcggccggtg cgtcggggca ccggcggggg ccgccgccgc aatccgcgcg ttcccgggaa
    15721 gggcggcgcc gcggcagccg ggggcggcct gcggaaatcg ccgcaacccg cctgcgagac
    15781 atggagcata gccctttcat tcttcccgac gggatgaaga tgtccttttc tcaggaatat
    15841 gctgttggac ctttcacatc ccataaaaaa gtggtcggac ttttgcacca ggattgcttt
    15901 accgatccat tccgtccggt aattccgggc tgacctgtgg gaataccccg gtcccccgga
    15961 cggcgccgtc ccggttcctc cggctgcctc gcccgagtgg tgagcggacg caccccgcca
    16021 caggctggtg atcgcctgtc tgtccccatc cggcaccccc ttcgacgcgc ggcgaggtcc
    16081 ggccatgcag ccaccaccgg tcaccggcac ccgggacgag cggccgcggc ggccgcggcg
    16141 gacaccgggg cggatcccct ggcgccggcc gcggcgcgcc ccgcgcggcg ccccggccga
    16201 cggcgccgtg cccggagccg cccggcccgg gaccgccgtc tccgggagca ccggcgccgg
    16261 gtggaccgcc cgcgccgtgc cgtacggtcc cgccgccgtc gcggtcctct tcaccctggc
    16321 gcaactggtt ctggtcgtcc ccggcaccgg cctcggctgg gacgagaccg tgtacgtcag
    16381 ccaggtcagc tcccacgcgc cggccgcgtt cttcagcgcc ccccgcgccc gcggcatcac
    16441 ctatctcgcc gcgccggtgg ccgccctcac cgacgccgtc ccgccgctgc gcgtctggct
    16501 cgcgctgctc agcggggccg ggctcttcct cgccctgcgg gtgtggcgcg atctgctgcc
    16561 ggcggcggtg ctcaccctgg ccgggggcct cttcgccggg ctctgggtca ccctcttcta
    16621 cggtccgctg gtgatgccca acctctgggt cgcgctggcc gcactgttca ccacgggctg
    16681 tctgctgcgg gccgtgcgga atccgtcctc ccggtgggcc ccggccggag tgtgcgcggg
    16741 ggtcgccctc gtcgccctga tgcgcccctc cgatgccctg tggctcgccc tgccgctggg
    16801 cgccgccctg ctgctggtcc gctcctggcg gcgcccgctg ctgctggccg ccctggtggc
    16861 gggcggcgcg ctgggcagcg cggagtggat cgccgaggcg tacagcgcgt acggcggctt
    16921 ggcggcccgg ctgagccggg ccagcgagat ccagggccac ctcgccccgt acttctccgt
    16981 ggacgaccac atccgcgcgc tcggcggccg caccctgtgc cggccctgtg acgtgccctg
    17041 gcggaacccg ggcaccggcg tctggtggtt cgcccttccc ctgctggccg gcgggggcgc
    17101 cctcgcggcc cgccgcaccc gccaccgggc cgagatcctg ctgcccgcgc tgaccgggct
    17161 cgtgctcgct ctgccgtatc tgttcctggt cggctacgcg gcgccccgct tcctgctgcc
    17221 cgcgtacgcg ctgctgtccc tgccggtcgc ccacggcctg ttccggctgg tgcggtgggt
    17281 gcgggaggcc cggcccgggc tgcgtccggc cgccgccgcg ctgtccgtga cggtgctggg
    17341 cctgcatctg ggcgtgcagt tcaccgtgct ccactccacg gtgtcctcct tccgggtcaa
    17401 cggagagagg ctggaccgga tggcggccga gctgggccgg cagggcgtcc ggccgccctg
    17461 tgtcgtctcc ggcccggacg cggtgcggat cgccttccgg gccggctgct cctcgcggca
    17521 ggtgggcggg cacgacggca gcatcacgca cgcggccctg cgggcgacgg cggagacgcg
    17581 gcccgtcgcc gtcctggtga cgaacggcgc cgatccgccg ccgtacgccc gggcctggcg
    17641 ctcccggccg ctgccggact tcggaccgtg gcggttccgc gcctatctgt caccggcggc
    17701 ccggccggac accggcccgg tgacggcccg ggactgacgg gcggcgcaca gcggaaggcg
    17761 gccctccggg acagccgtga ggctgttccg gagggccgcc ctggtgcggt cgctccctcg
    17821 gcgccgtccg tcagagggtg acgccgcgct gcttcaggaa ggccaccggg tcgataccgg
    17881 agccgtagtt cggggtggtg cgggtctcga agtgcaggtg cgggccggtg gagttaccgg
    17941 tggaaccgac cttgccgatc tcctgcccgg tggtcacctg ggtgccgacc ggaacggtga
    18001 tcttcgacag gtgggcgtac tgggtgaagg tgccggcgtc gtgcttgacc acgatgttgt
    18061 tgccgtacga gccaccccag ccggcctgga ccacggtgcc ctcgtgcacg gtcttcaccg
    18121 aggtaccggt cggcgcggcg aagtcctgac cggagtgctt gttcgcccag cggtcaccac
    18181 cgataccgaa ggtggagccc ttcacatagc tgtccaccgg cttcacccag gaagcgggag
    18241 ccttcgcggc ggcctgggtg acggtctccc gcttcgaacg gtcggcggcc tcctggccgg
    18301 cacgctcggc ggcggcggcc tcggccgcgg ccttgccctc ggcggccttc ttctgcgcct
    18361 cggcctgggc ggtgacggcc tcggacgcgg cgcgcgagtc ggcggcctcg gacgcggtgg
    18421 tcccggtggc ggggttctcg gtctcgccct gggtgcccag cgcgactccg gtccccagca
    18481 cggcggtggc tccgacaccg gcggccatga aggcggcgcg gcggcgcagg ggagtcatgt
    18541 cggtgaggat ctgagcgtgc ttgaacatca ggagttacct ccgaagtggg gggtttgcgc
    18601 gtttcgcgga tttcgtccgc ttgcgcccta ccttggtaac ccgccccgcc caggggttca
    18661 agcaccccca ctcctaccgg aggccgtagc cggcaccccc gcgcgccggc tgaggaatcc
    18721 cgccgtcggc acgcctgccg cggccgccgg acccgccctc cccgcgcggg agaaccggcg
    18781 cgctcccccg ctccccgtcc cgcaaacacg ccgcttgggc caccgtccgg tcacgccccg
    18841 cacacacggc gcccgggagc gctccgcacc ggggcggggc cgggcccccg ggtctcctat
    18901 cgcccctagt acgtgaggcg ggccacgtgc ggcaggtcac cggaaaccaa ggtcatcgac
    18961 ttctcggagg gctttccggg gctccgtgag cggtgctccg cggggcccgc acgggcgacc
    19021 gggagccacg gggccggcac tccgcgcgag ggccggggcc cgggagaggc cgggcagggc
    19081 aggccggccg gccccgcgag cggagggccg gcggcccggc agcggaagga gaagcgggga
    19141 cagcggccac gccccggtat acgcgccggg agccgccccg gccccaccgg gacggggccg
    19201 gggacgcgga cggggacgcg gacggggacg gggacgcggc agcggggccg ggtccccgtc
    19261 cggctcagct ctccccgccc tccagatcgc cctcggtctc caggaaggtc ctgcggagtt
    19321 cttcgagcac ggccgggtcc ggctccgccc acatgccgcg gctctcggcc tccagcaggc
    19381 gttccgccat gccgtgcagc gcccaggggt tcgcctcgcg gaggaagtcg cggttctccg
    19441 ggtccagcac ataggtgcgg gccagcgtgt cgtacatcca gtcggcgacg acgccggtcg
    19501 tggcgtcgta gccgaagagg tagtcgacgg tggcggcgag ctcgaaggcg cccttgtagc
    19561 cgtggcggcg catcgccgcg atccaccgcg ggttgacgac ccgcgcgcgg aagacccggg
    19621 aggtctcctc ggtgagggtg cgggtgcgga ccgtctccgg gcgggtgctg tcgccgatgt
    19681 acgcggcggg ggcggtgccc cggagcgtgc ggacggcggc gaccatgccg ccgtggtact
    19741 ggaagtagtc gtcggagtcg gcgatgtcgt gttcgcgggt gtcggtgttc ttggcggcca
    19801 cggcgatccg ccggtaggcg ctctccatct cgtcgcgcgc cgcgcggccg tcgagtccgc
    19861 ggccgtaggc gtagccgccc cagaccgtgt agacctcggc gaggtcggcg tcggtgcgcc
    19921 agtcgcggct gtcgatgagc tggaggaggc ccgccccgta ggtgccgggc cgggagccga
    19981 agatacgggt ggtggcgcgg cgttcgtcgc cgtgctcggc gaggtcggcc cgggcgtggg
    20041 cccggatgtg gttgtcctcg tcgctctcgt ccagcgaggc cgccagccgc acggcgtcgt
    20101 ccaggagccc gatgacgtgg gggaaggcgt cgcggaagaa gccgctgatg cgcagggtga
    20161 cgtcgacgcg cgggcgcccg aggtcggcga gcggtacagc ttcgagtccg gtgacgcgcc
    20221 gcgatgcgtc gtcccacacc ggccggatgc cgagcagggc gagcgcctcg gcgatgtcgt
    20281 cgccggcggt gcgcatcgcg ctggtgcccc acagggagag gccgacggac tcgggccagc
    20341 ggccggtgtc ggcgcggtag cgctccagga gggagtcggc gagcgccgat ccggtctccc
    20401 aggcgagccg gctggggacg gccttggggt cgacggagta gaagttgcgg ccggtcggca
    20461 gcacgttgac gagtccgcgc aggggtgagc cggacggccc ggcggggacg aagccgccgg
    20521 cgagggcgtg cacggagttc cgtatctcgt cgccggtggc ggccagccgg ggcaccacct
    20581 cgcgggcggc gaagcggagc acggcggcga cggcggcggg gtcctcgcgg gggccgtccg
    20641 ggaggccgat ggccggctcg ccggtctccc ccgcgcccgc gccggccgcg gctccgccgc
    20701 acacccgtgc gactgtctgc tccacggcgg cggggtccca gtccgcctcc tccatggcct
    20761 cgaccagggc gcgggcccgc tcctcggcct cgtccgcccc ggtgcgggag gccgccgact
    20821 cgtccaggcc gagggcctcg cgcagcccgg gcagggcggt ggtgccgccc cagatctgcc
    20881 gggcgcggag gacggcgagg acgaggttga cgcgctccgg cccggccggt gcctgcccga
    20941 gcacatggag cccgtcgcgg atctgcgcgt ccttgacctc gcacagccat ccgtcgacgt
    21001 gcagcaggaa gtcgtcgaag ccgtcgtcgt ccgggcggtc gtccaggccg aggtcgtggt
    21061 cgagccgggc cgcccggatg agggtccaga tctgggcgcg gatggcgggg agcttggcgg
    21121 ggtccatg
//
