LOCUS       NC_014925              22117 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Staphylococcus pseudintermedius HKU10-03, complete sequence.
ACCESSION   NC_014925
VERSION     NC_014925.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus pseudintermedius HKU10-03
  ORGANISM  Staphylococcus pseudintermedius HKU10-03
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus; Staphylococcus intermedius group.
REFERENCE   1  (bases 1 to 2617381)
  AUTHORS   Tse,H., Tsoi,H.W., Leung,S.P., Urquhart,I.J., Lau,S.K., Woo,P.C. and
            Yuen,K.Y.
  TITLE     Complete genome sequence of the veterinary pathogen Staphylococcus
            pseudintermedius strain HKU10-03, isolated in a case of canine
            pyoderma
  JOURNAL   J Bacteriol 193 (7), 1783-1784 (2011)
   PUBMED   21278300
REFERENCE   2  (bases 1 to 2617381)
  AUTHORS   Tse,H., Tsoi,H.W., Leung,S.P., Urquhart,I.J., Lau,S.K.P., Woo,P.C.Y.
            and Yuen,K.Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-DEC-2010) Microbiology, The University of Hong Kong,
            Pokfulam Road, Hong Kong, China
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000185885.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 09:14:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,530
            CDSs (total)                      :: 2,448
            Genes (coding)                    :: 2,410
            CDSs (with protein)               :: 2,410
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 14 of 38
            Pseudo Genes (incomplete)         :: 26 of 38
            Pseudo Genes (internal stop)      :: 5 of 38
            Pseudo Genes (multiple problems)  :: 7 of 38
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:32:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 70647
            Orig. end                         :: 92764
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP002439.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA and bacteria are available from Prof. KY Yuen
            (hkumicro@hkucc.hku.hk) at the Department of Microbiology, The
            University of Hong Kong.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22117
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="opine-like-metallophore"
                     /region_number="1"
                     /rules="(CntL and CntM)"
                     /tool="antismash"
     cand_cluster    1..22117
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(CntL and CntM)"
                     /kind="single"
                     /product="opine-like-metallophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22117
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12117](+)"
                     /cutoff="5000"
                     /detection_rule="(CntL and CntM)"
                     /neighbourhood="10000"
                     /product="opine-like-metallophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12117
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(CntL and CntM)"
                     /neighbourhood="10000"
                     /product="opine-like-metallophore"
                     /protocluster_number="1"
     gene            711..2663
                     /gene="spsN"
                     /locus_tag="SPSINT_RS00345"
                     /old_locus_tag="SPSINT_0071"
     CDS             711..2663
                     /codon_start=1
                     /gene="spsN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614888.1"
                     /locus_tag="SPSINT_RS00345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0071"
                     /product="LPXTG-anchored surface protein SpsN"
                     /protein_id="WP_015728543.1"
                     /transl_table=11
                     /translation="MLRTNYKLRKLKVGLVSTGVALTFVMASGNAEASENEQTEVKGEA
                     QVASVNEKESEAELPVAQQEASIQLDKVQPGDAQLSGYTQPNKAISVKIDNKDIVSVDD
                     GYEEVLSDDTGKFVYDLKGRQIVYNQKVDVEAMTPFNFEDFDESALESEEALEALGQLE
                     DEETATASVTTPRYEGAYTVPEERLTPIQGQQQVFIEPILEGASKIKGHTSVQGKVALA
                     INQEHVHLGDTLEEQAALTGQEWQGRYDGIWRHIDDQGFFEFDLNRLYNKSYPLKSGDL
                     VTLSFKSNDEVGPLFNVNVEPFERVAQAKTKYEQNDSPVVNKLDDTKSDLEVQPIYGDL
                     TQAAVHGESKVLIPGTSKVEGRTNYAHAWIEMASNLGEYRSFPTLQADATGAFIFDLKA
                     ADIQLLNGERLTFRAVDPHTKQQLAETTSEVRPVDMQDEESEVVQTSSTEKSALADEIL
                     RSMTIDKSFNPEVTEIPGHVYPKKTEDKGPENTEQASENSEKPSQTTESQNDAVQDVEK
                     SSVNEEVTPPSTESAQVEKGQNTEGALLPKNVEQHVESIPYQKRKALIGLTKHQGSGHM
                     PPFSLSFNNKEDDVSTKVNEANEHERKQGTVYPEQIEQLPQTGLTEKSPFWALLFVVSG
                     TGLLLFKRSRRQRQS"
     gene            3323..5377
                     /locus_tag="SPSINT_RS00350"
                     /old_locus_tag="SPSINT_0072"
     CDS             3323..5377
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614887.1"
                     /locus_tag="SPSINT_RS00350"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0072"
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="WP_015728544.1"
                     /transl_table=11
                     /translation="MNQYNQKSIYRIRKYTVGVVSVLATMTFLIGGHDAMASEQHTTQA
                     SSELARTEVTVSNQSLSEDTHTQSLSQKEGQHSHSGDSKNPKTSLFANASSQEQLPTTP
                     EQGVSSDNPNTSHPTHINENTNVPSLVDIQQEKGEKLSDVPNSEKVKTQSGSQIEAPPH
                     SNSRKAGRIAENQDLTSQQSDVALKDQSDVEVSKRVNHRSSEAMRARNVEKAQTDEIDQ
                     MTSQNLKPVVKDKTDQGKEQAIAEHKDQTKKGASEEEMTQKETTQEQQSQTRVANSKEV
                     LEKSSTQAQQKQSTNKYPIVLVHGFLGLVGENAPALYPNYWGGNKFKVIEALRKKGYDI
                     HQASVGAFSSNYARAVDLYYFIKGGRVDYGAAHAAQYGHERFGKIYKGIMPDWRPGKKV
                     HLIGHSMGGQTVRLMEELLRNGSKDEIAYHQKHGGTISPLFKGGLTDMVSSITTLGTPH
                     NGSQAADQVANKEFVRHIMYALSRVAGSEYSDFDLGLRHWGFKQRPGESYFDYMKRVSE
                     SPIWQTKDNAAYDLTLEGSAILNQKTSLNPNITYTTYTAEASHKGASGKEVPNVGVFPL
                     MDLTSRIIGSDARLEWRKNDGVVAVISSLFPLNQPFVKVSSDALATRRGIWQVRPVLKN
                     WDHVDFIGIDIFDLKRTGGELAKFYMSIMDNLLHIEALDMAAHIKKSAS"
     gene            complement(5621..7006)
                     /locus_tag="SPSINT_RS00355"
                     /old_locus_tag="SPSINT_0073"
     CDS             complement(5621..7006)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614886.1"
                     /locus_tag="SPSINT_RS00355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0073"
                     /product="APC family permease"
                     /protein_id="WP_014614886.1"
                     /transl_table=11
                     /translation="MKKLGFWSIVLLSINSIIGSGIFLTPGSVIRISGIYTPLIYVMAA
                     IFASILALTFASASKYVNKSGAAYSYTMVALGPHIGFYVGITRFIAGSIAWGVMATAVV
                     KTVITIFGGDHTDARLITLGFILLMGILLLINVLGKHLLVWVSNLSTIGKIAALLTVII
                     SGLYLVIQTGDTQFSRISTLVDTSQIDSQAFVMAIIAAFYAFTGFESIATGAQDMKSPE
                     KNLPRAIPLAIFMIAFIYIGVISITMTINPVALIQTKEVVSLVAVFDTPVIHRIILYGS
                     LISMFGINVAASFSTPRIIEAIAHEGQIPKWFKKRTVYDFPLPAFMLTFLIAIAIPLAF
                     QYNLTSIILLSSISRFIQYLIVPICVILFYYGKTSAPTLNHIRKNFFTDVLLPIFSFVL
                     TLVLLIKFNWKGQFLITNDAVTSFNYLGVASLVLSYVIFPIILYRLTPLSKKESTQIPR
                     KMT"
     gene            complement(7012..7749)
                     /locus_tag="SPSINT_RS00360"
                     /old_locus_tag="SPSINT_0074"
     CDS             complement(7012..7749)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614885.1"
                     /locus_tag="SPSINT_RS00360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0074"
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="WP_228197678.1"
                     /transl_table=11
                     /translation="MGALKLVTVGISANISYDTGGMFPGYERCYVNQDYIHTIVKHHAI
                     PLVLPIHTSQEIISQQIAHIDGLILTGGDDISPSLYHQDPYEKLGRTLLTRDLFDFKLL
                     EAAKRKGIPILGICRGAQIINVYHGGSLYQDLSYREAHTLRHHQKHIPTETTHTIHIEP
                     NSRLADAFETSQIMVNSFHHQTIQTLAPEFKAIAHATDGVIEAIEATNYPYLIGIQWHP
                     EMFWRESLMDRLFSDFIKICESK"
     misc_feature    complement(7728..7744)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.99"
                     /tool="antismash"
     gene            8094..8816
                     /locus_tag="SPSINT_RS00365"
                     /old_locus_tag="SPSINT_0075"
     CDS             8094..8816
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614884.1"
                     /locus_tag="SPSINT_RS00365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0075"
                     /product="hypothetical protein"
                     /protein_id="WP_014614884.1"
                     /transl_table=11
                     /translation="MKRLAFALFAFLLLLAGCGDKDSKKEEQSSTQNDKTEKTAKQQEK
                     TLENNKKEVADTTNESQQTENKGIDKDTKNNQQETKQKNVQNQSTDKQANVSHSPSHET
                     KKDLNEASRIALVFFGNDIQHYTITKSEILKGQYEYQGAGMTTTKNVNQLTLIHQRDIP
                     NAPSGMKFYTLDPPKGNFATIIGVNQNKVFVGGTQGALVDYQELLTTGKEMNLQSLYEA
                     YKNDPAYTSILNKIKIVN"
     misc_feature    9066..9081
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.23"
                     /tool="antismash"
     misc_feature    complement(9068..9082)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.98"
                     /tool="antismash"
     misc_feature    complement(9069..9084)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: strong, score: 29.38"
                     /tool="antismash"
     gene            9182..9991
                     /gene="cntK"
                     /locus_tag="SPSINT_RS00370"
                     /old_locus_tag="SPSINT_0076"
     CDS             9182..9991
                     /codon_start=1
                     /gene="cntK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614883.1"
                     /locus_tag="SPSINT_RS00370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0076"
                     /product="histidine racemase CntK"
                     /protein_id="WP_014614883.1"
                     /transl_table=11
                     /translation="MEIVHFSKFNPSGNMTVLVDSQHDPSQYRHIAQQLMKSSHVGCEQ
                     VGFIVDDEGELPHQLVMSGQEFCGNGTLSFIRYLKDRNLLTTSSFKLKVSGMDTPVHCA
                     IHETPQQFETTLPQPKKILERQYKIDDVLFEGLEIQYDTYQHFVFPITVWSEKLASSIE
                     SFVRAEEWPEHLTAVGLMLYDTLHQRLYPLIYVPQIDSIIWEQSCGSGTGSVGVYEAYQ
                     NQLEHLEKEIVQPGGALTAIVDHNDEGYQVAIKGNVSTVATGLAYIE"
     gene            10001..10819
                     /gene="cntL"
                     /locus_tag="SPSINT_RS00375"
                     /old_locus_tag="SPSINT_0077"
     CDS             10001..10819
                     /codon_start=1
                     /gene="cntL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     opine-like-metallophore: CntL"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019167820.1"
                     /locus_tag="SPSINT_RS00375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0077"
                     /product="staphylopine biosynthesis enzyme CntL"
                     /protein_id="WP_014614882.1"
                     /sec_met_domain="CntL (E-value: 1.8e-91, bitscore: 303.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKIQQNTHEIEAQLKHYQQQFEHLYHNIQQGERALNDLERLIDE
                     YSSYILDEQPKQQYEHWRSQTTEQQHLIKPLADITAKCVKLMESSRARRLIHGEHGTTG
                     YFDNIEHCISEEFGQFEITSEDTVLLVGSGAYPMTLVQIAKETGARVIGIDIDEEAVRY
                     GQQVIRILAPDAPIEIHQATVSELEGIQNVTHVIFSSTVEMKYDILEELYHLTGHDIVV
                     SMRYGDGLKSIFNYPKQETHPQQWTFVDDITRPDQIFDIALYQKKSEGRA"
     gene            10822..12117
                     /gene="cntM"
                     /locus_tag="SPSINT_RS00380"
                     /old_locus_tag="SPSINT_0078"
     CDS             10822..12117
                     /codon_start=1
                     /gene="cntM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     opine-like-metallophore: CntM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614881.1"
                     /locus_tag="SPSINT_RS00380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0078"
                     /product="staphylopine biosynthesis dehydrogenase"
                     /protein_id="WP_015728546.1"
                     /sec_met_domain="CntM (E-value: 2.7e-158, bitscore: 524.4,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKSVLIAGTGPVAVQLAVLFKTYTTHHVDMVGRSDVSAKAQQFW
                     QAYQNAQQLEVQVQNDLHMSLAGTATLGRLYERYEAVEPHYDVLVLACTADAYSQVIQQ
                     LSPAVRQQLKHVVLVSPTFGSHMVVQQQFSAEQPNIEVISFSTYLGDTTVSHPETPHRV
                     LTKGIKKHLYIGTIYEQSDFSQEIIDLLSEVQIPVTQVAHPLMAESRNSSLYVHPALFM
                     NEHALKAVFEGMTVPFYVYKLFPEGPITMQLIAEMRQMWQEVMAILKHLNIDTLNLLKF
                     MVKENYPLRPETMDDDRIEAFETLTAIEQEYLLYVRYTGILIDPFSEPDENGKYFDFSA
                     VPFKEVFRNEEGVWQIPRMPNEDYYRTQMMRGIAQALNISTPMMDTLIQRYEAQLTAFQ
                     KAHPNDRVSTQFQIQSFEEDINSIAKLLNSEG"
     misc_feature    complement(10851..10865)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            12353..13954
                     /gene="nikA"
                     /locus_tag="SPSINT_RS00385"
                     /old_locus_tag="SPSINT_0079"
     CDS             12353..13954
                     /EC_number="7.2.2.-"
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015413 - ABC-type nickel transporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0015675 - nickel cation transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nikA"
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015728547.1"
                     /locus_tag="SPSINT_RS00385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0079"
                     /product="nickel ABC transporter substrate-binding protein"
                     /protein_id="WP_015728547.1"
                     /transl_table=11
                     /translation="MMMKNLKWIAVSIVMLLVLAACGNSKALEQKKEDKNLTYATSKDI
                     GDMNPHVYGGSMSAQGMVYESLVDHTQKGIKPLLAESWDVSEDGKTYTFHLRKGVKFQD
                     GTPFNADAVKKNFDAIQANQKLHSWIKLSTLIDRTEAKDDHTFVMTLKEPYNATLEELA
                     MTRPYVFVSPKSFKAEGTKDGLKSYVGTGPYQLKSHDKDEQATFERNEDYWGGKPHLKT
                     IVAKVLPAGETSFLALQKGEVNFAFTDDRGTDNIDNEAMKKLTDNGDFQLKRSQPMNTK
                     MIVANSGKKDSPAQDKAVREALWYSVDQKRIADKILDGTEKPASQLFSKNVPHANIDLP
                     KRDFDLKKAAALLDEAGWKQNDKGEVREKDGQKLEMTLYYDNHSSSQKQEAEFIQAKAK
                     EIGMALKIVGETSDKVAERRTSGDYDLLFNQTWGLQYDPQSTISGFKADTGYKAAVSGI
                     KEKDQLFDDIDTALKTQDAKEQDQKYKDILTTVHDEAIFIPISHGGMTVVAPKDLEHIS
                     FKQSQYELPFEQMDYK"
     gene            13967..14899
                     /gene="opp1B"
                     /locus_tag="SPSINT_RS00390"
                     /old_locus_tag="SPSINT_0080"
     CDS             13967..14899
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="opp1B"
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015728548.1"
                     /locus_tag="SPSINT_RS00390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0080"
                     /product="nickel/cobalt ABC transporter permease"
                     /protein_id="WP_015728548.1"
                     /transl_table=11
                     /translation="MAYSAMKRLLLMIPLLIVISFLTFALTHLSSEDPAVVILHAQEVP
                     DITQSLIEQTRAKYHLDAPFLVQYWEWLQSAVQLQFGHSFVTGEDVGLRLWPAFFNTLK
                     LTLISSVAIIVLSLLFGILTALLRGTWFDRMTRTTAFVLTAIPSYWLAAILIIFLSVKL
                     NALPTSGLTGPESYILPVAVITLGYTGIYFRNVRSAVIQQLDQDYVLYMRAMGVPMSQL
                     LVYVARNAMQVVVSIFCMSIPIILGGSVVIENVFAWPGMGQLSVKAVLEQDFPMIQAYV
                     LIVSVLFILFNTLADVINMWLNPKLREEH"
     misc_feature    13984..13997
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            14901..15764
                     /gene="opp1C"
                     /locus_tag="SPSINT_RS00395"
                     /old_locus_tag="SPSINT_0081"
     CDS             14901..15764
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="opp1C"
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614878.1"
                     /locus_tag="SPSINT_RS00395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0081"
                     /product="nickel/cobalt ABC transporter permease"
                     /protein_id="WP_014614878.1"
                     /transl_table=11
                     /translation="MIVFQRLLNDNGAKWALAIIAVYILLGVFAPIVTPYDPNTVNIDD
                     KFAGMSFAHWLGTDHLGRDILTRLIFAIRPSFLLILFALACSVLIGTLLGFISGYFGRW
                     VDALVMRICDVMLSFPTYVMTLALIGVLGIGLKSIIVALIITRWAWFCRIIRTSVMQYR
                     NSDDVKFARTIGLSHARIIMTHILPRTLADIAIISTSSMVSMILQISGFSFLGLGVKAP
                     TAEWGMMMNEARKVMFSHPELMFAPGIAIIVIVLAVNFLSDALQIAIDPKLSQQQMKQR
                     IKKGWI"
     gene            15764..16582
                     /locus_tag="SPSINT_RS00400"
                     /old_locus_tag="SPSINT_0082"
     CDS             15764..16582
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019168634.1"
                     /locus_tag="SPSINT_RS00400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0082"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_014614877.1"
                     /transl_table=11
                     /translation="MVEQLMRVEDLTLIDGHTNHVLVHHFNLTLHRGEVIAIIGESGSG
                     KSMTCKALLGLNDRNIRMSGEIWFQEEALHNASEADFRKIRGRRIAMIMQQGATAFNPS
                     FTVGAQLTMMLKQHRPMSTQQQKATLQHYFDMLGLRDFERILKSYPHQLSGGMLQRLMI
                     ILALALQPDIIIADEPTTALDAITQYEVIEELREVKEKIGCAMIFVSHDLAVVKSIADQ
                     VIVMRNGDVVEAGPAHQLFTAPQHAYTQFLIAARDRVTRYYKSLRGDASC"
     gene            16576..17316
                     /locus_tag="SPSINT_RS00405"
                     /old_locus_tag="SPSINT_0083"
     CDS             16576..17316
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614876.1"
                     /locus_tag="SPSINT_RS00405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0083"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_014614876.1"
                     /transl_table=11
                     /translation="MLEVQNVTKSYRSGVKRQKRQIVKQVSFQCSKGQSIAIIGESGSG
                     KSTLARMILGIEKPDTGTVMLDGQPVCQRHTRLGKMSVVFQDYKSSLHPYFNVRQILNE
                     ALSQCDTPVDDKEAHMTALLERVGLSAAFLNKYPQMMSGGEAQRVAIARAVITNPDYIV
                     LDEAISALDMSIQSQILDLLTTLRDKYQLSLIFITHDIQAAVYLCEDLIIFNDGQIQER
                     LNRHQLKTLQNDYTRELFEKQFMN"
     gene            17328..18518
                     /locus_tag="SPSINT_RS00410"
                     /old_locus_tag="SPSINT_0084"
     CDS             17328..18518
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614875.1"
                     /locus_tag="SPSINT_RS00410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0084"
                     /product="MFS transporter"
                     /protein_id="WP_014614875.1"
                     /transl_table=11
                     /translation="MKGALAWPFLRLYILALFFFSANAILNVMIPLRGHDLGATNATIG
                     IVMGAYMLTAMLFRPWAGQVIAKVGPIKILRWILIINGFALILYGFTGLEGYFIARVMQ
                     GVCTAFFSMSLQIGIIDALPEEDRSQGISLYSLFSYIPGIIGPMIAVGIWQLDNLSYFA
                     LTMIIIAITTGVVGFSATLHGHDDADTTPAQQEKMPYGAMTVFLQLFKNPFLLKAGTIM
                     LVASIGFGAVATFIVLYVNKYQVGHASLFLAVQAITVVFARFFLRQYIPSDGRWHVRFM
                     LGVLGLLTVALLFIAIGPYVGGWILYISAVMIGLTQAMVYPTLTSFLSFKLPKVGRNML
                     LGLFIATADLGVSLGAALMGPIADMVGYANMYLICGILMAFITLMSIERRPQFIEK"
     gene            complement(18712..19140)
                     /locus_tag="SPSINT_RS00415"
                     /old_locus_tag="SPSINT_0085"
     CDS             complement(18712..19140)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614873.1"
                     /locus_tag="SPSINT_RS00415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0085"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_014614873.1"
                     /transl_table=11
                     /translation="MILSHKDFLYQIEEDGTTVTIYKNNDTKTYTAIEATGELTPHHFC
                     VLNYIKVDLNQSETFEERFLSRTADLNDVHGFISLRVLRPWDPQNHYVVISLWDDRKSF
                     EVWQASEQPLNYHHQWNGALDEEIVNSDLSYYIKFDAQ"
     gene            complement(19384..20556)
                     /locus_tag="SPSINT_RS00420"
                     /old_locus_tag="SPSINT_0086"
     CDS             complement(19384..20556)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614872.1"
                     /locus_tag="SPSINT_RS00420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0086"
                     /product="MFS transporter"
                     /protein_id="WP_014614872.1"
                     /transl_table=11
                     /translation="MKKYPIAIWMLAIGAFAIGMTEFVIMGLLPNVANDLNVSVSQAGQ
                     LITGYALGVAIGGPIIVMLTFRLNRKALLMLLMGIFILGNILGGLSPNYTTLMLSRIVT
                     SLAHGSFFGIGSILAASMVASQYRASAMALMFMGLSLSNILGVPFGTLIGQKLGWHMTF
                     LIIAVIGVIALIGIMMFVPMPKEMRTASIKDELRILKEKRLWLTLGMTLFGFSSVFAYF
                     TYISSVLIDVTHIPEQFISSILIVFGVGVTLGNIVGGKLADWNLNKALMSIFIIFVLYF
                     GLLYFIQFHPIIMVIGVFLFGFIGFSMSPSLQYKSTLISQEAPTLSSTLNQSAFNIGNA
                     LGAFIGGLVVSTLPIASLSLIAPLLTLIGLVFLLWSIAVEQKEQVNTHSN"
     gene            complement(20749..21498)
                     /locus_tag="SPSINT_RS00425"
                     /old_locus_tag="SPSINT_0087"
     CDS             complement(20749..21498)
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015728549.1"
                     /locus_tag="SPSINT_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0087"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_015728549.1"
                     /transl_table=11
                     /translation="MLYIFLSLLGIIGGILSGMVGIGGAIIIYPALLIIPPMLGLPSYN
                     AYIASGLTSAQVFFSTLSSSIRARQTPDFSLKLILWMGSSMLIGSALGATIAEVLTERF
                     VNSVYVVIAILALVLIMIKIKPQTEANLKFSKVVLLLTGLVIGAISGVIGAGGAFIIIP
                     VLLVFFKIPMHTVVANSVVIAFISSIGAFMFKLFQGYIPLGDALFLVVGSMLFAPLGLK
                     IGRQMPEYVQKGLVALLIIISILNLIF"
     gene            complement(21498..21758)
                     /gene="cstR"
                     /locus_tag="SPSINT_RS00430"
                     /old_locus_tag="SPSINT_0088"
     CDS             complement(21498..21758)
                     /codon_start=1
                     /gene="cstR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016911203.1"
                     /locus_tag="SPSINT_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPSINT_0088"
                     /product="persulfide-sensing transcriptional repressor
                     CstR"
                     /protein_id="WP_014614870.1"
                     /transl_table=11
                     /translation="MEYDKKMINRIKRVQGQLNGVIKMMEEEQHCKDIVTQLSASKGSL
                     QRLISIIISENLVECIKAAEENEENRQQIIDEAVNLLVKSK"
     misc_feature    21865..21881
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.07"
                     /tool="antismash"
ORIGIN
        1 ccataataca tataagagat gactgaggaa ttgacgtcat attctaaaac aagtgatgag
       61 caatgcaatc aagatgtcta ttgggggagg aaataaaaac ggtttatttt aacacaatat
      121 ttttatagct gtagacaaaa agacatctag agactctgac atgttaaagt caaaatttct
      181 agatgattat gattaggttt aatgatgatg ggcatatgag tttataaacg ttgagaatga
      241 aaacaacaat gatagatatg agatgaaata aataataaag tatagtacaa gaaatatatt
      301 gaaaataatg tgtataactt ggcatttaag atacggcacc ttttgatatg tttataaata
      361 atacgttttc ctatatgatg ttcgtcataa aaaagcttac taacaaaatg tgtcatcata
      421 atgagcagaa tagtaaactg tgattgtgcg ataacgatgc cataataatg ccaatccttt
      481 gtgagtagcc ctatttgtat aaaatgagtg agttggaaga gggtgtgtga ggttcacttt
      541 aggaggcatc tatattatta atatgtacaa ataaacaagc gaaaaaacta aaatccctga
      601 acgttagatg ccgtactttt aattaatagt taataatcag ttaataacat ttatttcatt
      661 aatatattaa agtatataaa gaatgaataa gtagaagagc gaggataaca atgttaagaa
      721 caaattataa actaagaaag cttaaagtag gtttagtatc gacaggtgtg gcgttgactt
      781 ttgtgatggc aagtgggaat gcagaggcgt cggagaacga gcagactgaa gtaaaagggg
      841 aggcgcaagt tgcttctgtg aatgaaaaag agagtgaagc agaattacct gtagcgcaac
      901 aagaagcatc tattcaacta gacaaagtac aaccaggcga tgcacagctt tcaggctata
      961 cacagccaaa caaagcgatt tctgtaaaga tcgacaataa agatattgtg tctgtagatg
     1021 atggctatga agaggtatta tcggatgata caggtaaatt tgtatatgat ttgaaagggc
     1081 gtcaaattgt ttacaatcaa aaagttgatg ttgaagcgat gacgccattt aattttgaag
     1141 attttgatga atcagcactt gagagcgaag aggcattgga ggcgttaggt caattggaag
     1201 acgaagaaac agcgacagct tctgtgacga cgcctagata tgaaggtgcg tatacagttc
     1261 ctgaagaacg cttgacgccc attcaaggcc aacagcaagt attcatcgaa cctattttag
     1321 aaggggcaag taaaatcaaa ggacatacat ctgtacaagg taaagtcgcg ttagcaatca
     1381 atcaagaaca tgtgcaccta ggtgatacgt tagaagaaca agcagcactc actggtcaag
     1441 agtggcaagg tcgttatgac gggatttggc gccatattga tgatcaaggg tttttcgagt
     1501 ttgacttgaa ccgtctttac aataaatctt acccattgaa gtctggcgat ttagtgactt
     1561 tatcttttaa atctaatgac gaagtaggcc cattattcaa tgtgaacgtt gagcctttcg
     1621 aacgtgtggc acaagctaaa acaaagtatg agcagaatga cagtccagta gtcaacaaat
     1681 tggatgatac taaaagtgac ttggaggttc aacctatcta tggagacctt acacaagcag
     1741 cagtacatgg cgagtcgaaa gtgttgatac cggggacgtc aaaagttgaa ggacgtacga
     1801 attatgcaca tgcatggata gagatggcat ctaatttagg ggaatatcgt agtttcccta
     1861 cattacaagc tgatgcgaca ggtgcgttta tatttgattt aaaagcggca gacatacaat
     1921 tgttaaacgg agaacgtttg acattcagag ccgttgaccc acatacaaaa caacagttag
     1981 ctgaaactac atcagaagta cgcccagtag atatgcaaga tgaagagtca gaggttgtgc
     2041 agacttcaag cactgagaaa tcagcacttg cggatgaaat tcttcgttct atgacaattg
     2101 acaaatcatt taatcctgaa gttaccgaga taccgggtca tgtatatcct aagaaaacag
     2161 aggataaagg tcctgaaaat acagaacaag cctcagagaa ttctgagaag ccatctcaga
     2221 ctacagaatc tcaaaatgat gccgtacaag atgtagagaa atcctctgtt aatgaggagg
     2281 ttacgccacc ttcaacagaa tctgctcaag ttgaaaaggg gcaaaataca gaaggggctt
     2341 tgcttccaaa aaatgtagaa caacatgtag agagtatacc ataccaaaaa cgtaaagcgt
     2401 tgataggact gacaaaacat caaggatcag ggcacatgcc gccattttct ttaagcttta
     2461 acaataaaga agatgacgta tcaacaaagg ttaatgaagc aaacgagcat gaacgtaagc
     2521 agggtacagt ttatccagag caaatagaac aattacctca aacaggttta actgaaaaat
     2581 cgccattctg ggcattgtta tttgttgtat caggcacagg tttattatta ttcaaacgtt
     2641 ctagacgaca acgccaatct taatagttga aaataatgtt atcatactgg atgtgttagc
     2701 atatggattg tattaaatga ctctactgtg aaagtagcca tgcaccatca tcagaaaaca
     2761 gtatagtgta acaaaaatct atagaacaat tatcaagcga aaacaatacg aggttttcgc
     2821 ttgtttgatt ttatgaattg tatacttttg cggttggtgg ggcatctact gaccgcattt
     2881 tatttttgat ataaaaaaca caaaaccgct atcattgtaa ttttcaaacc aataaagaag
     2941 atattgtgct tatgtacaat atgtaatgat attgaagaaa gacagagaat taaagttaaa
     3001 aactacttaa aaattggggt aacatgcaca tcaaaacgta atggcctatg atgcaaagat
     3061 taagataagc gcatgtttga caactataaa aatgggcagt taaatccaat tgatgattga
     3121 gacaactaag ggaagcaata aaacatagta cctaaaatat agactaaaat ctttaaccct
     3181 ttatcagata ttctgtaaat taataaattt taaatataat tttatgatac tatatatatt
     3241 tataactaat gtgatatatt atcattacag ttgtttaagg gggatttaat taaggggagt
     3301 taatcttatt agaggtgata tcatgaatca atacaatcaa aaaagtattt atcgtatcag
     3361 aaagtatact gtaggtgtgg tttcagtctt ggcgacgatg accttcttaa tcggtgggca
     3421 tgacgctatg gcaagtgagc agcatactac tcaagcatct agtgaattag cgagaacaga
     3481 agtgactgta agcaatcagt cgctaagtga agacactcat acacagtcgt tatctcaaaa
     3541 agaaggacaa cattctcatt caggtgactc taaaaatcct aaaacatcgc tattcgctaa
     3601 cgcttcatct caagagcaat tgcctactac accggagcaa ggtgtttcat cggataatcc
     3661 taacacgtct catcccactc atatcaatga aaatacaaat gtcccttctt tagttgacat
     3721 acaacaagag aagggggaaa aattaagtga tgttccaaac agcgagaaag tgaagacgca
     3781 atcaggtagt cagattgagg cacctcctca ttcaaacagc cgtaaagccg ggcgtattgc
     3841 agaaaaccag gatttaacat ctcagcaaag tgatgtggca ttaaaagacc aatcagatgt
     3901 tgaagtgagc aaacgtgtga accatcgatc ttctgaagct atgcgggctc gaaatgtaga
     3961 aaaagcacag acagatgaaa tcgatcaaat gacatcacag aatcttaaac cagttgttaa
     4021 ggataaaact gatcaaggta aagagcaagc tatagcagaa cacaaagatc aaactaaaaa
     4081 aggcgcttca gaagaggaaa tgacgcaaaa ggaaacaaca caagaacagc aatcccaaac
     4141 gcgtgtagcg aattctaaag aggtgttaga aaaatcatcc actcaagctc agcaaaagca
     4201 atctaccaat aaatatccta tcgtgttagt acatggattt ttagggttag taggtgaaaa
     4261 tgcaccagca ctctatccga attattgggg aggcaataaa tttaaagtta ttgaagcgtt
     4321 gaggaagaaa ggctacgata tacaccaagc aagtgttggt gcatttagta gcaattatgc
     4381 acgtgcagtg gatttatatt attttatcaa aggcggtcgt gttgattatg gtgcagcaca
     4441 tgcagctcaa tatggtcacg aacgctttgg taagatttat aaaggaatta tgcctgactg
     4501 gagaccaggt aaaaaagttc atttaattgg gcatagtatg ggaggacaga cggttcgttt
     4561 aatggaagaa cttttaagga atggtagcaa agatgaaatt gcgtatcacc aaaaacatgg
     4621 tggtacaatt tcgccacttt ttaaaggagg gctcactgat atggtttcat caataacgac
     4681 actcgggacc cctcataatg gctcacaagc tgcagatcaa gtggcaaata aagaatttgt
     4741 acgccatatc atgtacgcac tgagtcgggt ggcaggtagc gaatattcag actttgactt
     4801 aggtttaagg cattggggct ttaagcaaag acctggtgaa agttactttg attatatgaa
     4861 gcgtgtgagt gaaagcccaa tttggcaaac gaaagataac gcggcctatg atttaacatt
     4921 agaaggatcg gcaattttaa atcagaaaac aagcctaaac cctaatatta catacacgac
     4981 ttatactgct gaagcatcgc ataaaggggc ttcggggaaa gaggttccta atgtgggcgt
     5041 gtttccgtta atggatttaa cgagtcgcat tattggcagt gatgctaggt tagagtggcg
     5101 taaaaatgat ggggttgttg cagttatttc atcactattt ccattaaacc aaccttttgt
     5161 taaggtctca tctgatgctt tagcgacccg tagagggatt tggcaggtca gacctgtttt
     5221 aaaaaattgg gaccatgttg attttattgg tattgatatt ttcgatttaa agcgaacagg
     5281 tggagaacta gcgaaatttt atatgagtat catggataat ttattgcata ttgaagcgtt
     5341 agatatggcc gctcatataa aaaaatctgc atcttaatcc attgtattag gtttgagtaa
     5401 ccgaatatcg tcacatatcg cgttcacttt aaaagtttta atggagtaaa caaaaacatc
     5461 tgcatcgatt aaatgacgaa taagtcacta ctgcttgatg aagcggaatg acagttagag
     5521 acgtgcgctt gtgatgtata gcatgagaag gagtggtacg ttaaagcgat aattaatgaa
     5581 gttttttcgt cccactcctt atatttttca atcgtccatt ttaggtcatc ttacgtggta
     5641 tttgagtcga ctctttttta cttagaggtg tcaaacgata aagtattatt gggaaaatga
     5701 cgtaactcaa aactaatgag gcaacaccca aatagttaaa agatgttaca gcgtcgtttg
     5761 taataagaaa ctgccctttc caattgaatt ttataagtaa aacgagtgtc aatacaaaag
     5821 aaaatatagg taacaataca tccgtaaaga aatttttacg aatatgattt agtgtaggtg
     5881 cactcgtttt gccgtagtaa aataaaataa cacagattgg aacgattaaa tattgaatga
     5941 acctagaaat tgaacttaaa agaatgatac ttgtcaagtt atattgaaaa gccaaaggta
     6001 tagcaatagc gattaagaat gtcagcataa atgcaggaag cggaaaatca tagacagtac
     6061 gttttttaaa ccatttcggg atttggcctt catgggcgat agcttcaata attcttggcg
     6121 ttgaaaaaga agcagcgaca ttaataccaa acatggatat taagcttcca tacaaaatga
     6181 tacgatggat aacaggtgta tcaaatacgg ccaccaatga gacaacttct ttggtttgaa
     6241 tgagcgccac tggattgata gtcatagtga tggaaataac cccaatataa atgaatgcaa
     6301 tcatgaaaat agctagcgga atggctctgg gtaagttttt ttctggagat ttcatatctt
     6361 gtgcgcccgt agcaatactt tcaaatcctg taaaagcata gaaagcggct atgatggcca
     6421 taacaaatgc ttgtgaatcg atttgagaag tgtcgacaag tgtactgata cgactaaact
     6481 gggtatcacc tgtttgaata actaaataga gacctgatat gataacggta agtaaagcag
     6541 ctatttttcc aatcgtggag aggttgctga cccagactaa aaggtgtttg ccgagtacat
     6601 taatgagtaa caaaattccc attagcaaaa taaagcccaa cgtgataaga cgtgcatccg
     6661 tatgatcccc accaaaaata gtgatgacag ttttaacgac agctgtcgcc atgacgcccc
     6721 atgcaatact cccagcaata aaacgcgtaa tccctacata aaatccgata tgaggaccta
     6781 aagccaccat tgtataagaa taggcagcgc cacttttatt tacatatttt gaagcagatg
     6841 caaaagtgag cgctaaaata ctagcaaata tagcagccat gacatatatc agtggcgtat
     6901 agatccctga tattcgaatg actgatccgg gagttaaaaa gataccagaa ccgataattg
     6961 aattgataga taataatacg atagaccaga agcctaattt tttcatacat atcacttact
     7021 ttcacatatt ttaataaaat ctgaaaacag tcgatccatc aaactttctc tccaaaacat
     7081 ttcagggtgc cattgaatac cgattaaata aggatagttt gtagcttcaa tagcttcaat
     7141 aaccccatca gttgcatggg caatggcctt aaattcgggg gcgagtgttt gaatagtttg
     7201 atgatgaaat gagttaacca tgatctgaga agtttcaaat gcatcagcga gtcgagaatt
     7261 gggttcgata tggatggtat gcgtcgtttc agtaggtatg tgtttttgat gatggcgtaa
     7321 cgtatgtgct tcacgatagg ataaatcttg atataagctt cctccgtggt aaacattaat
     7381 gatttgtgca ccacgacaaa tacctaaaat tggaatacct ttacgcttag cagcttcaag
     7441 taacttaaag tcaaataaat cacgtgttaa aagcgttctg ccaagcttct cataaggatc
     7501 ttgatggtat agagatgggc taatatcatc accaccagtt aagattaaac cgtctatatg
     7561 tgcaatctgt tgtgaaatta tttcttgtga agtgtgaatc ggtaaaacta agggtatggc
     7621 atgatgctta acaatggtat gaatataatc ttgattgacg tagcaacgtt catatccggg
     7681 aaacattcct cccgtatcgt atgaaatgtt agctgatata cctactgtga ccaattttaa
     7741 tgcacccact atctataata atatttttaa gtatcatata aaacataata aatgtcaata
     7801 ttaaacagga gttatcttta aaagtgtcat gttattatat gagtgactta aaccgcatat
     7861 ttaatcaatg ttccgttaaa gggcgtatga ttaaaaagga catctattaa aaaaattgaa
     7921 tgagtgatgt aaacagctaa tgccattaaa gttttactaa agtgttttgc tataaaatat
     7981 gtatatttac tacatatatt tttctataag tctatggacc tattgtgtat agaaaaatat
     8041 ttgatatatt tataagtaga tagtaaaaaa tgtacttaaa tgaggtgttg aatatgaaaa
     8101 gattagcttt tgcgctcttt gcttttttac ttttattagc tggttgtggg gataaagatt
     8161 caaaaaaaga agaacaatca tcgacacaaa atgataagac agaaaaaacg gcaaaacaac
     8221 aagaaaaaac gttagagaat aataagaaag aagtggcaga cacaaccaat gagtcacagc
     8281 aaacagaaaa taaaggaatc gataaagata ctaaaaacaa tcagcaagag acaaaacaga
     8341 agaatgtaca aaatcaaagc actgataaac aagctaatgt gagtcattca ccttctcatg
     8401 agacaaagaa agatttgaac gaagcatcta gaattgcact cgtatttttt ggcaatgata
     8461 tccaacacta tacaataacg aagtcagaaa ttctaaaagg tcaatatgaa tatcaaggtg
     8521 ctgggatgac cactacaaag aatgttaatc aattaacatt aatccatcaa agagacatac
     8581 ctaacgcgcc atcaggtatg aagttttata ctttagatcc tccaaaagga aattttgcga
     8641 caattattgg tgtaaatcaa aacaaagtat ttgtaggtgg gacacaaggt gcgttggtag
     8701 attaccaaga gttgctcact acaggtaaag aaatgaattt acaaagtttg tacgaagcgt
     8761 ataaaaatga tccagcatat acgagtattc taaataagat taaaatagta aattaatagt
     8821 atgtatatat taaaacgggc tgtgaaaata tccatcacaa aagatgattt cacagctcgt
     8881 tttaatgtgt ttttacatgt tcaaacacag cttctgttaa tgtttcgcaa cgactttaaa
     8941 aatgtatctt aaattatgat gattcagcgg tctttgtacg atgacatcat tacaatggct
     9001 gactattaat aggaattttt agaagtagat atttagagat gaagatggat aataaaaagt
     9061 aaagttttga taatgattat cattgttgac atttcaaaaa tttgagagta ggatattttt
     9121 aaatcgttat gattacgatt tgtaattaat gatatttatt ttaaaaggag atggaataaa
     9181 attggaaatt gttcattttt caaaattcaa tccatctgga aatatgactg ttttagtgga
     9241 ttcacaacat gaccctagcc aatataggca catcgcccag caacttatga aaagttcaca
     9301 tgtgggttgt gaacaagtcg gatttattgt agatgatgaa ggtgagctac cacatcaact
     9361 tgtgatgagt ggccaagaat tttgcgggaa tgggactttg tcatttattc gttatttgaa
     9421 ggatagaaat ttactaacga cgtcctcttt taaattgaag gtatccggaa tggacacgcc
     9481 tgttcattgt gcgatacatg aaacacctca acaatttgaa acgacgctcc cacaaccaaa
     9541 aaaaatatta gaaagacaat ataagattga tgatgtcttg tttgaagggt tggaaattca
     9601 atatgataca tatcaacact ttgtattccc aattacagtg tggtcagaaa agctagcctc
     9661 ctctatcgaa tcgtttgtta gagccgaaga atggccagaa catctgacgg ctgttgggtt
     9721 gatgttatat gatacactgc atcagcgctt gtatcccctc atctatgtgc cacagataga
     9781 tagcatcata tgggagcaaa gttgtgggtc aggaacgggt tcggtaggtg tctatgaagc
     9841 gtatcaaaac cagttagaac atttagaaaa agaaattgta caacctggag gtgcgttgac
     9901 tgccattgtt gatcacaatg atgagggcta tcaagttgca atcaaaggaa atgtttcaac
     9961 ggttgccaca ggtttagcat acatagaata ggagtacgtg atgaataaaa tacaacagaa
    10021 cacacatgaa attgaagcgc aattaaaaca ttaccaacaa caattcgaac acctttatca
    10081 taacattcaa caaggcgaac gtgcacttaa tgatttggaa cgcttaattg atgaatatag
    10141 cagttatata ttggatgaac agcccaagca acagtatgag cattggcgga gtcagactac
    10201 agaacagcag catcttatta aaccactagc agatattact gcaaaatgcg ttaaattgat
    10261 ggagtcctct cgagcacgcc gtttgattca tggtgagcat gggacgacag gatattttga
    10321 caatattgaa cattgcattt cggaagaatt tggacagttt gaaattacat ctgaagatac
    10381 agtgctatta gtaggatcag gtgcgtaccc tatgacttta gttcaaattg caaaagaaac
    10441 aggcgcacgt gtcattggaa ttgatattga tgaagaagcg gtgcgctatg gacaacaagt
    10501 cattcgcatt ttagccccag atgcgccaat agaaatacat caagcaacag tatccgaact
    10561 agaaggaatt caaaatgtca cacatgtcat cttcagctca acggtcgaaa tgaaatacga
    10621 cattttagaa gaactttatc accttaccgg tcatgacatt gtggtgtcta tgcgttatgg
    10681 tgatggcttg aaatctatat ttaattatcc taaacaagag acacatccgc agcagtggac
    10741 ttttgtagat gacattacac gtccggatca aatctttgat attgcactct accaaaaaaa
    10801 atcagaaggg cgtgcataat aatgaaaaaa tctgtcttaa ttgcagggac aggtccggtc
    10861 gccgtgcagc ttgcagtgtt attcaagacc tatacaacac atcatgtaga tatggtgggg
    10921 cgaagcgacg tttcagcaaa ggcacaacag ttttggcaag cataccaaaa tgcacagcaa
    10981 cttgaagtac aagttcaaaa tgacttgcat atgtcgttag caggtactgc aacacttgga
    11041 cgattgtatg agcgttatga agcagtcgag ccacattatg atgtgctcgt gcttgcatgt
    11101 actgccgatg catacagtca ggttatacaa cagttgtctc cggctgtacg tcaacaactc
    11161 aaacatgtcg tgcttgtttc tcctacgttt ggttctcata tggtcgtcca acagcagttt
    11221 agtgcagaac agccgaatat tgaagtgatt tcattttcta catatttagg tgatacgact
    11281 gtatcgcatc ctgaaacacc acatcgtgta ctgacaaaag gaataaaaaa acatttgtat
    11341 atcggtacaa tatatgaaca atctgacttt tcccaggaaa taatagattt gttatctgaa
    11401 gttcaaattc cagtgacgca agttgcccat ccactcatgg cagagtcgcg aaacagctca
    11461 ctttatgtgc atccagcgtt atttatgaat gaacatgctt tgaaagcagt gtttgaagga
    11521 atgaccgtac cattttatgt atacaaatta tttccagaag gtcctattac gatgcagtta
    11581 atcgctgaaa tgcgacaaat gtggcaagaa gttatggcga tattgaaaca tttaaatatc
    11641 gatacgttaa atctattgaa atttatggtg aaagaaaatt acccccttcg ccctgaaacg
    11701 atggatgatg atcggattga agcgtttgaa acacttacag ccatcgagca agaatattta
    11761 ttatacgtac gttataccgg tattttaatt gatccgtttt cagagccaga tgaaaatggt
    11821 aagtattttg atttttcagc agttcctttt aaagaagttt ttcgaaatga ggaaggtgtt
    11881 tggcaaattc ctcggatgcc gaacgaagac tattaccgta cacaaatgat gcggggtata
    11941 gcacaagcat tgaacatttc cacgccaatg atggatacat tgattcaacg ctatgaagca
    12001 caactgacgg catttcaaaa agcacatcct aatgatcgtg tatccacgca atttcaaata
    12061 cagtcgttcg aggaagatat caacagtatc gctaaattat tgaactctga aggataaagg
    12121 gaatgtgtta agttcattga ttggatgaaa ttccattttg agaaccagta aaaatgactg
    12181 tgaaacaaaa ttcaactatg aagtgactgg attgataaaa gtgttcaagg tgggtcatca
    12241 tgagtaccca ttgacactga tatttatacg ctaaagacaa tcaagcaaat ttaacaatgt
    12301 gtactaaaaa tgctagcact actgaaagaa atgagataaa gagaggatat gaatgatgat
    12361 gaaaaattta aagtggattg ccgtaagtat agtaatgtta cttgtacttg cagcctgtgg
    12421 taactctaaa gcattagagc agaaaaaaga agataaaaat cttacatatg ccacatcgaa
    12481 agatattggg gatatgaacc cgcatgtata cggtgggtca atgtcagcac aaggtatggt
    12541 ctatgaatca ttagttgatc atacacaaaa agggattaaa ccgttattag ctgaatcttg
    12601 ggacgtatcg gaagatggaa aaacctacac attccactta agaaaaggtg taaaattcca
    12661 agatgggaca ccgtttaatg cagacgccgt gaaaaagaac tttgatgcta ttcaagcaaa
    12721 tcaaaaatta cattcttgga ttaaattatc aacattaatc gaccgtacag aagcaaaaga
    12781 tgatcatacc tttgtgatga ctttgaagga gccatataac gcaacgttgg aagaactagc
    12841 catgacacga ccttacgttt ttgtctcacc aaaatcattt aaagcagagg gtacaaaaga
    12901 tggtctgaaa tcttatgttg gtacaggtcc atatcaattg aagtcacatg ataaagatga
    12961 gcaagcgaca tttgaacgta atgaagatta ttggggtggc aaaccacatt tgaaaacgat
    13021 agtcgctaaa gtattaccag caggtgaaac atcattttta gcgttacaaa aaggtgaagt
    13081 gaactttgcg tttacggatg accgtggtac agataacatc gacaatgaag caatgaaaaa
    13141 attaacagac aatggcgatt tccaattgaa gcgtagtcaa ccgatgaata cgaaaatgat
    13201 tgttgcaaac tctggtaaaa aagacagccc tgcacaagat aaagcggtgc gtgaagcatt
    13261 gtggtatagc gtcgatcaaa agcgtattgc ggacaaaatt ttagacggta ctgaaaagcc
    13321 tgcgtcacaa ttattctcga aaaacgtgcc gcatgcgaac attgatttac caaaacgtga
    13381 ttttgatttg aaaaaagcag cggcgctatt agacgaagcg ggatggaagc aaaatgacaa
    13441 aggtgaagtg cgtgaaaaag acggtcaaaa gcttgagatg acgctatatt atgacaacca
    13501 ttcaagctcg caaaaacaag aagctgaatt tattcaagcg aaagcgaaag aaattggtat
    13561 ggcattgaaa attgtaggag aaacatctga taaagtggca gagcgccgta catcaggtga
    13621 ttatgactta ctgtttaacc aaacatgggg tcttcagtat gatccacaaa gcacgatttc
    13681 tggctttaaa gcagatacag gttataaagc agcggtttca ggtatcaaag aaaaagacca
    13741 actgtttgat gacattgata cagctttaaa aacacaagat gcaaaagagc aagaccaaaa
    13801 gtataaagac attttaacaa cagtacatga tgaagcaatc tttattccga tttctcacgg
    13861 aggtatgaca gttgtcgctc cgaaagattt agaacatatt tcatttaaac aatcacaata
    13921 cgaattgcca tttgaacaaa tggattacaa ataaggtggt ccatcaatgg catatagtgc
    13981 gatgaaacgt ttgttactga tgataccgtt gttgattgtc attagctttt tgacttttgc
    14041 attaacacat ttatctagtg aagatccagc cgtcgtcatt ctacatgcac aagaagtacc
    14101 agatattacg caaagtttaa ttgaacaaac acgtgccaag taccatttag atgcgccgtt
    14161 cctcgtacaa tactgggaat ggctgcaatc cgcggtacag ctacaatttg gacatagttt
    14221 cgtaactggc gaagatgtcg gtttgagact atggcctgca ttttttaata cattgaagtt
    14281 aacattgatt tcaagtgtgg cgattattgt gttgtcgctg ttgtttggta ttttgacagc
    14341 attgttgcgt gggacatggt ttgatcgtat gacacggacg acagctttcg tattaaccgc
    14401 gattccatct tattggctag cggcgatatt gattattttt ctatcagtta aattgaatgc
    14461 attaccgacg tcgggattaa caggtcctga aagctatatt ttacctgttg cggtgatcac
    14521 gcttggttat accggcattt attttagaaa tgtcagaagt gcggtcattc agcaacttga
    14581 tcaagattat gtgctctata tgcgagcgat gggtgtgccg atgtcgcaac tgctcgttta
    14641 tgtggcacgt aatgcaatgc aagtcgtcgt ttctattttt tgtatgtcga ttcctattat
    14701 tttaggcggt tctgtcgtca tcgaaaatgt atttgcgtgg ccgggtatgg gtcaactgag
    14761 tgtcaaagcc gtgttggaac aagattttcc aatgattcaa gcatatgttc ttatcgtttc
    14821 ggtactattt atcttattta atacattggc agacgtcatt aatatgtggc tgaacccgaa
    14881 attaagggag gagcattaag atgattgttt tccaaagatt attaaatgat aatggcgcaa
    14941 aatgggcgtt ggcaatcatt gctgtttata ttttactcgg ggtattcgcg ccgattgtaa
    15001 cgccttatga ccccaataca gtgaatatcg atgacaaatt tgccggcatg tcatttgcac
    15061 attggcttgg tacggaccat ttaggtcgag atattttaac acgcttgatt tttgcgatac
    15121 gtccgagctt tttgcttatc ttgtttgcgt tagcgtgttc ggtgttgata gggacgctac
    15181 tcggcttcat ctcaggctac tttgggcgct gggtggatgc actcgtgatg cgtatttgcg
    15241 atgtgatgtt atcgtttcct acatatgtta tgacgctcgc tttgatcggt gtactcggca
    15301 ttgggttaaa aagtattatc gttgcactga tcattacgcg ctgggcatgg ttttgccgaa
    15361 ttatccgcac aagtgtgatg caatatcgca attcagatga tgtgaaattt gcacgtacga
    15421 ttggtctgtc acacgctcgg attattatga cacacatttt gccgcgaact ttagcagata
    15481 ttgcgatcat ttcaacgagt tcgatggtgt cgatgatctt acaaatttca ggattttcat
    15541 ttttaggact cggcgttaaa gcaccgacag cagaatgggg gatgatgatg aatgaagcac
    15601 gtaaagtgat gttcagtcac cctgagttga tgtttgcgcc aggtattgcg attatcgtca
    15661 ttgtgttagc ggtgaacttt ttatccgatg cgctccaaat tgcgattgat ccaaaattgt
    15721 cacaacaaca aatgaagcaa cgcattaaga aagggtggat ataatggtag aacaattgat
    15781 gcgtgtagaa gatttaacac tcattgatgg tcatacgaac catgtcctcg tccaccactt
    15841 taatttgacg ttacatcgtg gtgaggtcat tgcgattatc ggtgaaagtg gcagtggtaa
    15901 atcgatgacg tgtaaagcat tactgggatt gaacgaccgt aatattcgaa tgagcggtga
    15961 aatttggttc caagaagagg cgcttcataa tgcgtctgaa gcggactttc gaaaaatcag
    16021 aggccgacgt attgcaatga ttatgcaaca aggtgcgaca gcgtttaacc cttcttttac
    16081 agttggtgca cagttgacga tgatgttgaa acagcaccgt cctatgtcga cacaacaaca
    16141 gaaggcgacg ttacaacatt acttcgacat gcttggttta cgagattttg agcgtatttt
    16201 aaaatcatat ccgcatcaat tgtcaggagg catgttgcaa cggttaatga ttatattagc
    16261 actcgcactc caaccggaca tcattattgc ggatgagccg actacagcac tcgatgccat
    16321 tacacagtat gaagtcattg aagaattacg tgaggtcaaa gaaaaaatcg gttgtgccat
    16381 gatttttgtc tctcatgact tagcagttgt aaagtcgatt gcagatcagg ttattgtgat
    16441 gcgtaatggt gatgtcgttg aagcaggacc agcacatcaa ttattcacag caccgcaaca
    16501 tgcgtacact caatttttga ttgcagcacg agatcgtgtg acacgttatt acaaatcatt
    16561 gcgaggtgat gcgtcatgtt agaagttcaa aacgtcacga aatcttatcg tagtggtgtg
    16621 aagaggcaaa aacgacaaat cgtgaaacaa gtcagttttc aatgcagtaa aggacaaagt
    16681 atagcgatta ttggagaaag tggtagtggt aaatccacat tggcgcgtat gatattaggt
    16741 attgaaaagc cagatacagg aactgtgatg ttggatggac aaccggtctg tcaacgtcat
    16801 acccgtcttg ggaaaatgag cgtcgtgttt caagattaca agtcttcact gcatccctat
    16861 ttcaatgttc gtcaaatttt aaacgaggca cttagtcaat gcgatacacc ggttgacgat
    16921 aaagaagcgc atatgactgc tttgctcgaa cgtgtcgggt taagtgcagc ctttttaaat
    16981 aaatatcctc agatgatgtc aggaggagaa gcgcaacgtg tcgctattgc aagagcggtc
    17041 attacgaatc cagactacat tgtgttagat gaagcgatta gtgcgctcga catgtcgatt
    17101 cagtcgcaaa ttctagattt attaacgaca ctgagagata aatatcagct cagtttgatt
    17161 ttcattacac atgatattca agcggcggtc tatttatgtg aagatttgat catttttaat
    17221 gacggtcaaa ttcaagagcg actcaataga caccagttga aaacgcttca aaatgattat
    17281 acgcgtgaac tttttgaaaa acaatttatg aattaggagg ctttgatatg aaaggtgcac
    17341 tcgcttggcc ttttttgaga ttgtatattc tcgcgctatt tttctttagt gcgaatgcta
    17401 ttttaaatgt catgatcccg ttacgcggac atgatttagg tgcaaccaat gcgaccattg
    17461 gtattgtcat gggggcatac atgttgactg ccatgctttt tcgtccatgg gcagggcaag
    17521 ttatcgccaa agtcggtccc attaaaatat taagatggat attaattatt aatggttttg
    17581 cactgatctt atatggattt acaggtttag aaggttactt tattgcacgt gtgatgcaag
    17641 gtgtatgtac agcctttttc tctatgtcat tacaaatcgg gattatcgat gcgttacctg
    17701 aagaggatcg ttcacaaggt atttccttat actcactctt ttcttacata ccaggcatta
    17761 tcggaccaat gattgcagtg gggatttggc aattggataa cttgagttat ttcgcattga
    17821 cgatgatcat tatcgcgatt acgacaggtg tggtcggttt cagtgcgacg cttcatggac
    17881 atgatgatgc agacacgact cctgcgcaac aagaaaagat gccatatggt gcgatgacag
    17941 tgttcttgca gttatttaaa aatccgtttt tattaaaagc tgggacgatt atgcttgttg
    18001 cctcaattgg atttggtgca gtggcaacgt ttatcgtgtt gtatgtcaat aagtatcaag
    18061 tcggtcacgc gagtttattt ttagctgtac aagccattac ggttgtattt gcacgtttct
    18121 ttttacgtca atacattcct tcagatggac gctggcacgt tcggtttatg ttaggtgtcc
    18181 tcggattatt aactgtcgcg ctgttattca ttgcaatcgg tccttatgtc ggcggatgga
    18241 tactttatat cagtgctgtt atgattggtt tgacgcaagc gatggtgtat ccgacattaa
    18301 cttcattttt aagctttaaa ttaccgaaag ttggacgaaa tatgttactc ggtctcttta
    18361 tcgcaacagc tgacttaggt gtttcactcg gggctgcatt aatggggcct atagcagata
    18421 tggttggcta tgcaaatatg tatctcattt gtggtatttt aatggcattc attacactga
    18481 tgagtattga gagaagaccg cagtttatag aaaaataacg tagaaaatga acaggctagg
    18541 gtgcatttca aagtttccta gcctgttttc aattgaaaaa ataaatttta aaggtaaaga
    18601 aatatcttaa taaaacagta ttagtgacaa agccttgagt ttcgaaatat attttaataa
    18661 cagaaaatat acacaagtgg ttattaaaat tttgaaaaat cgctatacac atcattgtgc
    18721 atcaaattta atataatatg acaaatcgga attcacaatc tcttcatcta atgcgccatt
    18781 ccattgatga tggtaattca atggttgctc agaagcttgc cacacttcaa aacttttacg
    18841 gtcatcccat aatgaaatca caacataatg attttgtggg tcccagggtc tcaaaacacg
    18901 tagcgatatg aagccatgta catcattcaa atctgctgtg cgacttagaa agcgttcctc
    18961 aaatgtttca ctttgattca gatctacttt aatataattt aagacacaaa aatgatgcgg
    19021 tgtgagctcg cctgtcgctt ctatagcagt atatgttttg gtatcattat ttttatatat
    19081 ggtcactgtt gtcccatctt cttcaatttg ataaagaaaa tctttatgag agagtatcat
    19141 gctttatacc tccttatact tattaacaaa tacccgttat ttcacatttt aattgcacaa
    19201 attaaattta tcgcaaatta tatattacat tttctaaatt caatgtaaaa tttaaaaacg
    19261 aatattaaat taaaaaccgc cacatatctt tatgtagcgg tgaatcagca gcataatgaa
    19321 acatatagag agggcaacat agtattaaaa aatttttaaa tgtcatattt tataaattaa
    19381 actttaattc gaatgtgtat tgacctgttc tttttgttcg acagcaatac tccataataa
    19441 aaagacgagt ccaattaatg tgagtaatgg cgcgattaaa cttagactag cgatggggag
    19501 tgtgctgaca acaagaccgc cgataaaagc acctaatgca tttccgatat taaaggcgga
    19561 ttgattgagt gtactggaaa gtgtcggcgc ttcttgggaa atgagcgtac ttttgtattg
    19621 aagtgaaggg ctcatgctaa agccaataaa accgaaaaga aagacgccga tcaccatgat
    19681 tatcgggtgg aactgaatga agtagagcag tccaaagtaa agcacaaaaa taataaaaat
    19741 gctcattaat gctttgttta aattccaatc tgcaagcttg ccacctacaa tattaccgag
    19801 tgtcacgcca acaccgaata caatcagaat agatgaaatg aattgttcag gaatgtgggt
    19861 cacatcgatg agtacagatg aaatataagt aaagtaggcg aacacactac taaaaccgaa
    19921 caatgtcatc ccgagagtta accacagtct tttttctttt aaaatgcgca attcatcttt
    19981 gatagaagcg gtacgcattt cttttggcat cgggacaaac atcataatgc cgatgagtgc
    20041 aatgacgcca atgacagcaa taattaaaaa tgtcatgtgc caaccgagtt tttggccgat
    20101 taatgtaccg aatggcacgc cgagaatgtt gctcaggctg agacccataa acattaatgc
    20161 cattgcactt gcacgatatt ggcttgcgac catacttgca gctaaaatag agccaatgcc
    20221 gaaaaatgag ccatgtgcaa gtgatgtgac gatacgactg agcatcaatg tcgtgtaatt
    20281 cggactgaga ccaccgagaa tgttaccgag aataaaaatg cccatcagca acattaacaa
    20341 cgctttacgg ttaagtcgga aagtgagcat gacgatgata gggcctccaa tcgcgacacc
    20401 taaagcgtaa ccagtaatca attgtcctgc ctggctcaca gacacattta aatcattcgc
    20461 cacgttagga agtaagccca tgatgacgaa ttcagtcatt ccaatcgcaa atgccccaat
    20521 cgctaacatc catattgcaa taggatactt cttcataatg gatccctcct gatttatctt
    20581 tttaacaggg ttatcgtaca tatcttatag ttataattca atatgtgggt ctttaccaga
    20641 aaatcaaagt aagctcttgt tcgtatagtt ttgttgatat ttagttaact tatgaactag
    20701 gtttgatttg tatggttgga agagctgatt tcattaaagt acgacggctt agaaaatcaa
    20761 attcagtata gagatgatga taaggagagc aaccaaccct ttttggacgt actcaggcat
    20821 ttggcgtcct atttttaagc caagtggcgc aaataacata cttccaacaa ctaagaataa
    20881 tgcatcacca agcggaatat acccttgaaa aagtttaaac ataaaggccc ctatagaaga
    20941 aataaaagca atcacaacac tatttgccac gacagtatgc atcggtattt tgaaaaaaac
    21001 taataatact ggaataatta taaaggcgcc tccagcccca atcacaccag aaattgcacc
    21061 aatgactaaa cctgtcaata gcagtacaac tttactgaat tttaagtttg cttctgtttg
    21121 tggtttgatt ttaatcatta ttaagacgag tgccaatata gcaatgacaa catatacgct
    21181 atttacgaat ctctctgtta atacttctgc aattgtagct cctaacgcac taccgatgag
    21241 catgctactt cccatccaaa gaatgagttt aagagaaaaa tccggtgttt gacgcgcacg
    21301 tattgaactg cttaaagtac taaaaaatac ttgcgcagat gtaagtcctg aagcgatata
    21361 agcattgtaa gaagggaggc caagcatagg gggaataatg agtagtgcgg gataaataat
    21421 aatcgcaccg cctataccta ccatacccga gagaatgcca ccaataatac cgaggagcga
    21481 gagaaaaata taaagcatta tttacttttc accaataagt tcacagcttc gtcaatgatt
    21541 tgttgtctat tttcttcgtt ttcttctgct gccttaatac actctactaa attctcacta
    21601 ataataatac taatgagacg ttgtaacgaa cctttagaag cacttaattg tgtcacaata
    21661 tccttgcagt gctgttcttc ttccatcatt ttaatgacgc catttaattg accttgaact
    21721 cttttaattc ggttaatcat ttttttatcg tattccatac cttatgtcct cctaaagtaa
    21781 tatatgaggt ttatcatata aaaaagcaag aaatttgtca aatacccccg taggtatttg
    21841 acaagagatt cagcatccat tattataccc ctataggtat ttggaggagg tctaatattg
    21901 aattttagtg aacttgagat aaaaagttta aagaaagatg aacttgagcg attaggagaa
    21961 ctagggcaat tgatagatgt tcgtacggat gaagaatatc aagaaggaca catccgaggg
    22021 gcaaaatctt ggccgttgga tcaaattgaa ttatttaaag gtgataaaaa tcaaacgtat
    22081 tatctttatt gcagaagtgg aaagagaagt gcacaag
//
