LOCUS       NC_015953              22070 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. SirexAA-E, complete sequence.
ACCESSION   NC_015953
VERSION     NC_015953.1
KEYWORDS    GSC:MIGS:2.1; RefSeq.
SOURCE      Streptomyces sp. SirexAA-E
  ORGANISM  Streptomyces sp. SirexAA-E
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7414440)
  AUTHORS   Takasuka,T.E., Acheson,J.F., Bianchetti,C.M., Prom,B.M.,
            Bergeman,L.F., Book,A.J., Currie,C.R. and Fox,B.G.
  TITLE     Biochemical properties and atomic resolution structure of a
            proteolytically processed beta-mannanase from cellulolytic
            Streptomyces sp. SirexAA-E
  JOURNAL   PLoS One 9 (4), e94166 (2014)
   PUBMED   24710170
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7414440)
  AUTHORS   Lucas,S., Han,J., Lapidus,A., Cheng,J.-F., Goodwin,L., Pitluck,S.,
            Peters,L., Ovchinnikova,G., Davenport,K., Detter,J.C., Han,C.,
            Tapia,R., Land,M., Hauser,L., Kyrpides,N., Ivanova,N., Pagani,I.,
            Adams,A., Raffa,K., Adams,S., Book,A., Currie,C. and Woyke,T.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Complete sequence of Streptomyces sp. SirexAA-E
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7414440)
  AUTHORS   Lucas,S., Han,J., Lapidus,A., Cheng,J.-F., Goodwin,L., Pitluck,S.,
            Peters,L., Ovchinnikova,G., Davenport,K., Detter,J.C., Han,C.,
            Tapia,R., Land,M., Hauser,L., Kyrpides,N., Ivanova,N., Pagani,I.,
            Adams,A., Raffa,K., Adams,S., Book,A., Currie,C. and Woyke,T.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2011) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B310, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. SirexAA-E
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            environment                       :: Soil, Terrestrial
            num_replicons                     :: 1
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Free living
            trophic_level                     :: Missing
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: Missing
            sequencing_meth                   :: WGS
            assembly                          :: Newbler v. 2.3 (pre-release)
            finishing_strategy                :: Finished
            GOLD Stamp ID                     :: Gi05895
            Funding Program                   :: DOE-GLBRC 2008
            Source of Isolate :: Cameron Currie (currie@bact.wisc.edu)
            Cell Shape                        :: Filament-shaped
            Motility                          :: Nonmotile
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram+
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Finished
            Current Finishing Status          :: Finished
            Assembly Method                   :: Newbler v. 2.3
            Genome Coverage                   :: 30x
            Sequencing Technology             :: 454/Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000177195.2-RS_2024_05_08
            Annotation Date                   :: 05/08/2024 02:12:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,619
            CDSs (total)                      :: 6,532
            Genes (coding)                    :: 6,385
            CDSs (with protein)               :: 6,385
            Genes (RNA)                       :: 87
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 147
            CDSs (without protein)            :: 147
            Pseudo Genes (ambiguous residues) :: 0 of 147
            Pseudo Genes (frameshifted)       :: 61 of 147
            Pseudo Genes (incomplete)         :: 120 of 147
            Pseudo Genes (internal stop)      :: 8 of 147
            Pseudo Genes (multiple problems)  :: 39 of 147
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:50:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6577010
            Orig. end                         :: 6599080
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP002993.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4086644
            Source DNA and organism available from Cameron Currie
            (currie@bact.wisc.edu)
            Contacts: Cameron Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LANL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22070
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22070
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22070
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12070](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12070
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    450..463
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
     gene            complement(863..1204)
                     /locus_tag="SACTE_RS28715"
                     /old_locus_tag="SACTE_5782"
     CDS             complement(863..1204)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SACTE_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SACTE_5782"
                     /product="hypothetical protein"
                     /protein_id="WP_141708008.1"
                     /transl_table=11
                     /translation="MVGTEPSDVVRRWAVPAGRPVFFPVLNMQHPRSCARTPRSLAVAE
                     ATASLNGLPLPLRELTAPFMRGGTQRYAWGVWGGIGPLIPGAYASEIKGRATSGFWVDT
                     TYHLESKPF"
     gene            complement(1292..3847)
                     /locus_tag="SACTE_RS28720"
                     /old_locus_tag="SACTE_5783"
     CDS             complement(1292..3847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049521.1"
                     /locus_tag="SACTE_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5783"
                     /product="DUF262 domain-containing protein"
                     /protein_id="WP_014049521.1"
                     /transl_table=11
                     /translation="MRAQEITFLKLVQGEKQFQVPLYQRTYSWGEEQLRRLWEDVGELV
                     DRHLSGQDSTPHFLGSVVLDPGRLQAGGVQRWLVVDGQQRLTTLMLAFTALRDHYKECG
                     DPRAADRVHRQILVNEFHEGLDHYRLLPTQADREAYTSCVGSRPQAGGGDSIGGAYRYF
                     RGVLAEGREGADGHQWVATVETVLKDLLSIVEITAEHGDNVYRIFESINNTGVGLSQSD
                     LLRNYVFSLLRNRGERVYQELWLPMQQSLGPKNLELLVWLDLIVRGHHTAKQSEIYREQ
                     QKRLQPLASDEEALHHEIAELAERGTRFLRVIEPHREPSPALRGMLERLTAWGGQTHYP
                     LALHLLGLVDTGDTTPEDAAEALLYVESYLVRRLICQTPTTNLNRIFMEAPKELETDRS
                     AAEAVRRFLSGRRRRWPSDDELRDAMRGKPFYWSGRPPQRGYILRRLEESYRPTEPVDF
                     AKASLSVEHVLPQRPTQAWFDQLADETEDGQTPQELHDLLVHTLGNLTLTGDNSKLSNS
                     PFERKQQILDSSALRMNLEIAASGRWGKAEILARADRLSERAVGLWPGPVGGASVRPAG
                     EEWAGWAELRAALVALPSGSWTTYGDVAELIGSHPVAVGGHLAANPAVIGAHRVLTADG
                     RVSAGFRRVDGSDRRPPQELLAAEGVRFDSLGRAHRSQRLTAAELATLLGKDVARPAPG
                     DPLPDGENTEAAERFRGQLRRHWPEASAGLLSSLDFWRRQGGYVTYGRSEETSCFPMLD
                     VGTSVDSRVMWPFGLYPVSGTVEVVFQYLKDRSPFDDVEQRRALLRRLNEIDGITLSEA
                     KLELRPSFPLSVFAEHAEEIDGVLEWFVHTAALGLPGGL"
     misc_feature    complement(3560..3562)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4061..4294)
                     /locus_tag="SACTE_RS34315"
     CDS             complement(4061..4294)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SACTE_RS34315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_141708009.1"
                     /transl_table=11
                     /translation="MQVLVDAGPKARGVADAGRALAARLEPLLDDAEAASGYAHMLGAD
                     PRAPRSTTACPRTSPAAAFRRPPEVTWKAELG"
     gene            complement(4427..5299)
                     /locus_tag="SACTE_RS28725"
                     /old_locus_tag="SACTE_5784"
     CDS             complement(4427..5299)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-271). E-value:
                     5.3e-24. Score: 77.1. Matches aSDomain:
                     nrpspksdomains_SACTE_RS28725_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049522.1"
                     /locus_tag="SACTE_RS28725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5784"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_014049522.1"
                     /sec_met_domain="PF00561 (E-value: 6.5e-19, bitscore: 67.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.4e-12, bitscore:
                     46.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERFIDVTPEVRLWAEERGAVDAPPLLLIMGAQASGLGWPDELVD
                     ALAVRHRVIRYDHRDTGRSTWAFDEAPYALTELAHDAIAVLDAFGVARAHVVGMSMGGM
                     LTQLLIADHPERMLSATLLGTSALSTAPYVRPDGTRVPPEELPGIAPHILELWARPVED
                     HGLEAELDRRVEHWRALGGDGLPFDAEATRDSERRVIEHTGHHTAGTAHARADAADMLR
                     TEQLAATDVPTLVVAAPADPLFPPPHPQHLAQVIRGARLTEIPGMGHALPHEVLAPLTA
                     AILGHTARH"
     aSDomain        complement(4487..5230)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SACTE_RS28725_Abhydrolase_1.1"
                     /evalue="5.30E-24"
                     /label="SACTE_RS28725_Abhydrolase_1.1"
                     /locus_tag="SACTE_RS28725"
                     /protein_end="271"
                     /protein_start="23"
                     /score="77.1"
                     /tool="antismash"
                     /translation="PPLLLIMGAQASGLGWPDELVDALAVRHRVIRYDHRDTGRSTWAF
                     DEAPYALTELAHDAIAVLDAFGVARAHVVGMSMGGMLTQLLIADHPERMLSATLLGTSA
                     LSTAPYVRPDGTRVPPEELPGIAPHILELWARPVEDHGLEAELDRRVEHWRALGGDGLP
                     FDAEATRDSERRVIEHTGHHTAGTAHARADAADMLRTEQLAATDVPTLVVAAPADPLFP
                     PPHPQHLAQVIRGARLTEIPGMGHAL"
     gene            5536..6366
                     /locus_tag="SACTE_RS28730"
                     /old_locus_tag="SACTE_5785"
     CDS             5536..6366
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049523.1"
                     /locus_tag="SACTE_RS28730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5785"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_014049523.1"
                     /transl_table=11
                     /translation="MNNQQPPSADTRDTVPAAYRVDITRPHSARFWNYFVGGRDNYEVD
                     RAIGDQIKAFFPGLVDVAVAGRQFLRRSVTHLVQERGVRQFLDIGTGLPSADNTHQVAQ
                     SLAPESRIVYVDNDPLVLTHARALLSSTREGATDYIDADLYDPAAILAAAGDTLDFDRP
                     VALMLLGILGHADDFGRARDVVRELMAGLPSGSYLAVYDGTRTSAGMIAAEEAYIESGA
                     VPYYVREPDEIVTLFDGLRMLDPGFVRLSEWWPDADSAQVPADVDAYGGVGMKE"
     gene            6427..7074
                     /locus_tag="SACTE_RS28735"
                     /old_locus_tag="SACTE_5786"
     CDS             6427..7074
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049524.1"
                     /locus_tag="SACTE_RS28735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5786"
                     /product="MerC domain-containing protein"
                     /protein_id="WP_014049524.1"
                     /transl_table=11
                     /translation="MSGNRAAATYGVPDTAPEGPPRPPLSTARKAVGSLVWAVALPAVI
                     ILGAGLGQWMTWLGVVVMLGAVAVAACLIGGVWHRAGAATLASVAGFGLMLFAGPAVYE
                     VYMKTVGDPVAAVVTEVTDRQQRRGPDMFCTVEETGGDRTRHEVSQQENCFGQAAVGDR
                     VEIRKDPLGLFDPRLPDSPDQRNTTEITVAVTTGLALLTAAATFYGGQRRRG"
     gene            7177..7353
                     /locus_tag="SACTE_RS35615"
     CDS             7177..7353
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SACTE_RS35615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019993006.1"
                     /transl_table=11
                     /translation="MVTAVICLVAGAAVTGCTDGGAEKERPADQVLEESHETMNALKTV
                     TIDASTTPTARSP"
     gene            7350..7550
                     /locus_tag="SACTE_RS35620"
     CDS             7350..7550
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SACTE_RS35620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019993005.1"
                     /transl_table=11
                     /translation="MKVTDKEDAEGVYTFHVATEGKPYLLKVAYQGADYRSTTFFSAFD
                     APLGVRPPADADVLDTSAAGR"
     gene            complement(7625..8425)
                     /locus_tag="SACTE_RS28745"
                     /old_locus_tag="SACTE_5788"
     CDS             complement(7625..8425)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049525.1"
                     /locus_tag="SACTE_RS28745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5788"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_014049525.1"
                     /transl_table=11
                     /translation="MNDDAQSTPHPANAHPARVYDVWLGGKDHYQVDQEAAQLAARANP
                     TIVPSVRANRAFLGRAVRHLAAAGIRQFLDVGTGIPAADNTHEVAQRAVPEARVVYVDN
                     DPIVLSHARALLVSGPDGQTAYVQADARDVDTILEAASRTLDLDEPVGLMLVAILQYIK
                     DSEDPWDITRRLLDRLAPGSYLVLSHPAVDVTAPEVAASMRIYNERAADHASATPRTRE
                     EVERFCEGLEILEPGVVTLTRWRPEPTDVPDDTLPMWCVVARKA"
     gene            complement(8574..>8801)
                     /locus_tag="SACTE_RS28750"
                     /old_locus_tag="SACTE_5789"
                     /pseudo=""
     CDS             complement(8574..>8801)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566164.1"
                     /locus_tag="SACTE_RS28750"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5789"
                     /product="VOC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="PAMSEETAEQVRALVAKGAMGGSLIFTTADCQKTYETLLGKGVEF
                     TDEPTDRPYGIDCGLRDPFGNRIRFTQPKG"
     gene            complement(8917..9555)
                     /locus_tag="SACTE_RS35625"
                     /old_locus_tag="SACTE_5790"
     CDS             complement(8917..9555)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049526.1"
                     /locus_tag="SACTE_RS35625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5790"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_014049526.1"
                     /transl_table=11
                     /translation="MSDDHIGVTFSALRDLADDLEDIIKQLNEKLETLYARTEKVVLTW
                     EGEARDTFVDELDKWDRQMRRPLHRLDLSLEAPVSLKPLEHDHAEGELDQVDRAYLGRT
                     ADDEEAITDCLRRTCRTRPWSIANAEFQLRECARNPPGRLRPRLGEFCPLPDVGLPDAQ
                     IQAWLLMLADRLKESVETGQAPPPAPPRTDWEWRARFPELAQLLGGWYS"
     misc_feature    9510..9527
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    9686..9695
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            10001..12070
                     /locus_tag="SACTE_RS28760"
                     /old_locus_tag="SACTE_5791"
     CDS             10001..12070
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="SACTE_RS28760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5791"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_014049527.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.3e-46, bitscore:
                     155.9, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="T1TS (E-value: 9.6e-31, bitscore: 106.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSSGIDLAVFPRLQADLDRVRDAFGPVRVHGRPELDALTHEETG
                     ASRGLVRPTLALLSYYVLTDPSEPADDRAVLAAAAAELLHLGALYHDDVMDHAYERRGR
                     PSANALWGQHLAILAGDCVMLSGLGMLAELGRREVAEGVAASERMCAGMVRESADLHAA
                     SRSEESYLQAVGGKTAELFALACRLGAMQANGNGGRQEDGREEALAGFGWQLGHAYQLR
                     DDILDLTSTAEELGKPVNTDLAEGVYTLPVIRAVSRDQGLARLLGKELTQEEAARARGL
                     VLASGAVEETQAVADAYVVRAADRLSTLTDHPRALDELKSYARTLLRGRGARAAVVPRQ
                     ARQESQARAGAHGEQVTRWVKNWLVETGLAATPAEADHHRLSGAMWMIERILPQAAGAP
                     ADGEGGDDDSSARKRATAAMGTLICVWDDIFEDPLLTSPRAVTELREDLVATLRQDPAA
                     PWTHGAIPTAWARLWPRLRAGRTARWQEAFLDSIEQTFHACEREAHHRISGHIPSTGDY
                     LPLRRSTSGFEIGMGCSEVLQNREIPPTLRGHRMVRRLEELAFFVIFAENDLAGLDQDE
                     ADGIPYNLVRVIRHETGCGRAEAVERVERQVAEKRAQYNAILTYVPVLFRTLPGLSGDS
                     DGYAAIYDRLKLFVDVRQRGSERYRPNTLAVGPDLERLRREISRRPAAPVSSER"
     misc_feature    10661..10663
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12153..12296
                     /locus_tag="SACTE_RS34420"
     CDS             12153..12296
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SACTE_RS34420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157839233.1"
                     /transl_table=11
                     /translation="MRTARRSQPAPGPGDPLHLSRGEAEETGLNAALFALPAVVAWLSG
                     TW"
     gene            complement(12331..12597)
                     /locus_tag="SACTE_RS28765"
                     /old_locus_tag="SACTE_5792"
     CDS             complement(12331..12597)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969066.1"
                     /locus_tag="SACTE_RS28765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5792"
                     /product="hypothetical protein"
                     /protein_id="WP_014049528.1"
                     /transl_table=11
                     /translation="MALVKRVALAPRAVRQLRRVRSVYVAGMLLSALGLLSYDDTAAGA
                     RQTVITAVFLVVFAALLALTTVQLWRHARTKHCSTAKKLSPVA"
     misc_feature    complement(12678..12693)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    12698..12708
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            12778..13992
                     /locus_tag="SACTE_RS28770"
                     /old_locus_tag="SACTE_5793"
     CDS             12778..13992
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049529.1"
                     /locus_tag="SACTE_RS28770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5793"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_014049529.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-39, bitscore:
                     134.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTQHETGTGAGTAHRVLVLGAGYAGIAAAVQLAARTARRTDVAV
                     TVVDAQERFTERLRLHMTATGQQLAELSVPALLEGTGARFVRGWVTSVDADARTVRLDD
                     ERCLCYDTLVYALGGVADTAAVPGAGEHAYTLNGTQDAQVLAERLDRLGGGTVVVCGNG
                     PTGIEAAAEIAERHPELGVVLLGRREPGTALHPRAGAYLRGALDRLGVQVRGGTTVVGI
                     RPGAVETADGGSIAADVVLWAGGTRVSPIAAAAGLAVDARGRVVTDETLRSVSHPQVYA
                     VGDAAAIRQGYGVMHGTCQGGMPSGVHAAVSIVRALRGKQPKPFRFGYYHTPVSLGRHD
                     GVVQFTHPDDSPRRIYLTGRAAARYKEVVTASPWPTYGRMKKMPASGAFWPRGGRSTRV
                     RGGVR"
     gene            13989..14972
                     /gene="sigJ"
                     /locus_tag="SACTE_RS28775"
                     /old_locus_tag="SACTE_5794"
     CDS             13989..14972
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="sigJ"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062910.1"
                     /locus_tag="SACTE_RS28775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5794"
                     /product="RNA polymerase sigma factor SigJ"
                     /protein_id="WP_026359070.1"
                     /transl_table=11
                     /translation="MTQQPEQADPLVFQRHRSLLFSVAYRILGSAADAEDAVQDAWIKW
                     SAADRSQVADPRAYLARIVSNLALERLRSTRNKRETYVGPWLPEPILTGAENAGGIGST
                     GNTGNAWSTATADAADTVVNAESVSMAMLVVLETLSPLERAVFVLKEVFGFSHAEIAET
                     VERSEAAVRQAAHRAREHVRAGRPRFPADRSRQREVTERFLAAATGGDVNALMELLSPD
                     VTLWTDGGGKVRQALRPVVGAQTVAAWFAAIGTVSYQGVEPTDMHAELVEINGGPGLLF
                     SAPGRPVATVTFDFDAEGSITAVHNVANPDKLRAVAEGTTHDVRVR"
     gene            complement(15024..16436)
                     /locus_tag="SACTE_RS28780"
                     /old_locus_tag="SACTE_5795"
     CDS             complement(15024..16436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049531.1"
                     /locus_tag="SACTE_RS28780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5795"
                     /product="VanZ family protein"
                     /protein_id="WP_014049531.1"
                     /transl_table=11
                     /translation="MLEAVFKDQGAFVLVAAGAVSAAALLAYLGARKHTRRPWSYAGLA
                     AALTAEVGVTLLLPSAGGESRRCVVVRDLGEPFATEQGLLNLAMFLVVGFLGVLAVRRV
                     VPVFLGASSLSVVTELCQGLLPWIGRSCDSSDVQMNVLGAALGALAGAASVRAFRGGLR
                     PLTSALRPTLLAFGSGILVCGVVGSCWITPVAVDPTSLRLAGGAEREAARQAVTAAFGD
                     HERIVNVQVMPGWDGGADTLLIALETGSAELSGPDGEVFSADFSTPPEQPGPAGFPVAG
                     AAGPRNADDALRTATSYAEERFPWALSGTIATSTPVGARAESGWVVAWRGNTDGVVAPT
                     RLDVRIDREGRVAALLARHVKDAPTTFPPRRVSEKRALAAAAAYYPGAVSGAVELLAVR
                     RDGAWRAQWFVPVASAPVTAAGAPVTVDVVPVYVDAETGQVDDRPTPPHGLPTVLPPTA
                     EESVETVELPDS"
     misc_feature    complement(16637..16650)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.53"
                     /tool="antismash"
     gene            16699..17328
                     /locus_tag="SACTE_RS28785"
                     /old_locus_tag="SACTE_5796"
     CDS             16699..17328
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049532.1"
                     /locus_tag="SACTE_RS28785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5796"
                     /product="hypothetical protein"
                     /protein_id="WP_014049532.1"
                     /transl_table=11
                     /translation="MALVQLDLPHPTAMRGRWAALAAVQAASGRGERCQAHWPLWHYDD
                     GHGSWADLHHLDEGRAVLLGQDRNDSETYYAEAADFFEEKETDLLAGAPAWWEPPVRRV
                     RDADADLFLAFVYGFDGTAWWRAPYDAEDGFGSVGLPALDDDRTRAAIRAATGHAPDGD
                     EPPRAALDTLIAADGEVDEALLAAVVPPSDTDVAVGAAAARGFLAR"
     gene            complement(17457..18566)
                     /locus_tag="SACTE_RS28790"
                     /old_locus_tag="SACTE_5797"
     CDS             complement(17457..18566)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049533.1"
                     /locus_tag="SACTE_RS28790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5797"
                     /product="CU044_5270 family protein"
                     /protein_id="WP_014049533.1"
                     /transl_table=11
                     /translation="MNDRTSGPERAEHEELARLLPAPAERDLPPGRHLHHKDTLMRLID
                     QDGDRATARPRLPRPAVLLPAAGLALGGVLLTTIAVTGQDSTPAPSPAGTSSQATAPRA
                     AVLLDRIASVAEKSDEQAVTGDQFVYVKTLQAGNEGEYGGPVKLSEPGEREVWMSQEPG
                     PVIDEGLIHQDGSYFPITVGVPDGETPVGYPAGLNRPTYAWLASLPTDADVLLRRLDTE
                     ITRDQDARDTPAEDRDRAQDTFDAIGQLLMETVMPPKTAAALYKAAAKIPGVTVDSDAV
                     DAAGRHGIGVARDNTRSGWRTVWIFDSTTLEYLGDRSYLIRDSTMGRKGTPLSESAVLE
                     RAVVDALRERPSDHKSSAQKSSAGKPSTT"
     gene            complement(18563..19231)
                     /locus_tag="SACTE_RS28795"
                     /old_locus_tag="SACTE_5798"
     CDS             complement(18563..19231)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952958.1"
                     /locus_tag="SACTE_RS28795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5798"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_014049534.1"
                     /transl_table=11
                     /translation="MRARIRAGDREAFAALYEEYARAVYNHAYRLTGDWSTAEEVLSDT
                     FLAAWRTRRSVEPEGDSLRPWLLGIATNKARNANRGIGRRLAFLARRPAPEPVADIADA
                     TAGRVDDVRRLAAVQRALGGLRRQEREVLVLCVWSGLDYAEAAEALGVPVGTVRSRLSR
                     ARTRLRRLTDEELGQEPDGAVRGARPGEVVRSGREPRSGRGEVESRAAFVALPIQEEAR
                     "
     gene            <19572..>19667
                     /locus_tag="SACTE_RS35265"
                     /pseudo=""
     CDS             19572..>19667
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976379.1"
                     /locus_tag="SACTE_RS35265"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="arabinan endo-1,5-alpha-L-arabinosidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGDLLVHHSNDGQDNGAPKPGVNLPNRSSGWP"
     gene            19718..>20053
                     /locus_tag="SACTE_RS35270"
                     /pseudo=""
     CDS             19718..>20053
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036760.4"
                     /locus_tag="SACTE_RS35270"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPRAFTGRRVRRVPLDEARRARGPQFVKPPTDKSFPAAVHETGET
                     LPTPAGHPHDVLVQISEVVIWVREFRLFLLDGEIRTGSRCATFGRLDAAPLAGHPDEGV
                     VRAFARRL"
     gene            20148..20282
                     /locus_tag="SACTE_RS35475"
     CDS             20148..20282
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SACTE_RS35475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_256059209.1"
                     /transl_table=11
                     /translation="MVEANMAWFSNVYAADPVRALDLVLRSAGPAADLRAPDARFRRR"
     gene            <20521..21489
                     /locus_tag="SACTE_RS28805"
                     /old_locus_tag="SACTE_5800"
                     /pseudo=""
     CDS             <20521..21489
                     /GO_function="GO:0030599 - pectinesterase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042545 - cell wall modification [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004929759.1"
                     /locus_tag="SACTE_RS28805"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_5800"
                     /product="pectinesterase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AAAATTLTVAKDGTGQYTTVQAAVNAIPAGNTARVVVSIRPGTYR
                     ETVKIPSNKQNVTLQGSGSSRKDTVIVHANASGTPKPDGSGTYGTSGSATVAAEADGFQ
                     ARNLTISNDFDEAAHQDMADRQAVALRTAADKVFLDSVIVTGDQDTLLLDTASKAALGR
                     VYMVNSYVVGNVDFIFGRASAVIDRSVITLKKRWDGSSAGYVTAPSTAAGRKGFLITAS
                     TVNGDVAAAAFHLGRPWHAGGDASLDPMATFRDTTLGAGVKSAPWTDMSGFSWKDDRFA
                     EYRNTGPGSGPASSERPQLTDSQAAAQETADWLAGWTPTAS"
ORIGIN
        1 tctcgacgct gaactcctcg gtgtcggtca ccccgctgtt cgggttgtag cagtcgccgg
       61 tgtcgagcga gaagaccgac cgctggcgca ccgccttctt cgcgcccgac ttggcttcct
      121 cgacgatgtc ggcgcatccc gtcgctccga ctgccaggag gacgacgacg gcagctatgg
      181 agcgcaggga acgggactgg gcaccgaaag acatgagttg tgcatcctca acgggagaaa
      241 tggcgaacag gtgtgcgcat cgtatggcac gcctgtgacg gaagtgtgag cagctacctc
      301 cgcttactcg gaggtggccg gacggtgaag tccgggccgc ctccccgaac ggcgccgccg
      361 cgggcgggtg ttcgggagac gccgagtgtc cgagagggtg ccactgtcca gtgaagcata
      421 cgtgtgaact cagtcaatag tcgacacgtt ggatcgcatc gaagcgggac ggggtgcgcg
      481 gtgccgtgtg tccctggtcc ggcgcgtgac cgaccgggcc cgtatgagcg gacggggccc
      541 ggtcggcggc cggtcggcgg tgggtggcgc ggccgccgac ctccggtcat gcgccaggtc
      601 ccgacaacca ggtcgacggg cgcggggcac atgcccggag gggcgttccg ccggacgccg
      661 tcaggggaac tcaagggcat ggcccaccgc ttcctgcccc gggaccggca cgactggctg
      721 ggcggccgac gcgtaccggg tcaccggacc gtgtccgccc cggcgccctg cgggacctgg
      781 ccaccgacac cagccgcgcg gcggacctcg gacagccggc tcgccgcagg tccgcaggtc
      841 cgcagggcca caccggtccg gatcagaagg gcttcgactc caggtggtac gtcgtgtcga
      901 cccagaagcc gctcgtcgcc ctgcccttga tctccgacgc gtaagcgccg ggaatcagcg
      961 gcccgatgcc gccccagacg ccccacgcgt agcgctgggt cccgcccctc atgaagggtg
     1021 cggtgagctc ccgcaggggc agtggcaggc cgttgagaga cgcggtcgcc tctgccacgg
     1081 ccagggaccg aggggtcctc gcacaggagc gggggtgctg catgttgagc accgggaaga
     1141 acaccggccg gcccgccggt accgcccagc gccgcaccac atcagagggc tctgtgccga
     1201 ccacacgggc tgggctacga cgcaccgaaa cgtgcacacc gggcagcgca caccgggaat
     1261 gcgcacaccg gcaatcgcgt gccccaagcc gtcagagacc gccgggcagg ccgagggccg
     1321 ccgtgtggac gaaccattcc agtacgccgt cgatctcctc cgcgtgctcg gcgaagacgc
     1381 tgagcgggaa ggacgggcgc agttccagct tggcttccga cagggtgatc ccgtcgatct
     1441 cgttgaggcg ccgcaacaac gcgcgccgct gctccacgtc gtcgaacggg ctgcggtcct
     1501 tgaggtactg gaagacgacc tcgacggtgc cggagacggg gtagagaccg aacggccaca
     1561 tcacgcgcga gtcgacggac gtgcccacgt ccagcatcgg gaagcaactc gtctcctcgg
     1621 accggccgta ggtgacgtaa ccgccctgcc tgcgccagaa atcgagtgag gacagaagac
     1681 cggccgaggc ctccggccag tgccgcctca gctgcccccg gaagcgttcg gccgcctcgg
     1741 tgttctcgcc gtccggcagc ggatcgcccg gcgcaggcct cgctacgtcc ttgccgagga
     1801 gcgtggccag ttcggccgcg gtcaggcgct gcgagcggtg agcccggccc aaggagtcga
     1861 accgtacccc ctccgccgcc agcagttcct gcggaggccg cctgtcgctg ccgtcgaccc
     1921 gacggaagcc cgccgagacc ctgccgtcgg ccgtgaggac ccggtgggcg ccgatcaccg
     1981 cagggttcgc cgccagatgg ccgccgacgg ccaccggatg actgccgatc agttccgcca
     2041 cgtctccgta cgtcgtccag gaaccgctgg gcaacgcgac gagagcggcc cgcagctccg
     2101 cccagcccgc ccactcctca ccggccgggc ggaccgaggc gccaccgacc gggccgggcc
     2161 acagtccgac cgcccgttcc gacaaccggt ccgcgcgggc caggatctcc gccttgcccc
     2221 agcgcccgga cgcggcgatc tccagattca tccgcagagc gctggagtcg aggatctgct
     2281 gcttgcgctc gaaaggactg ttggagagct tcgagttgtc tcccgtgagg gtgaggttgc
     2341 cgagcgtgtg caccaggaga tcatgcagct cctggggggt ctggccgtcc tcggtctcgt
     2401 cggcgagctg gtcgaaccac gcctgggtgg gccgctgcgg taggacgtgc tccacactga
     2461 gggacgcctt ggcgaagtcc acgggctcgg tcggccggta gctctcctcc aggcgacgca
     2521 ggatgtagcc ccgctggggc gggcggccac tccagtagaa cggtttgccg cgcatcgcgt
     2581 cccgcaactc gtcgtcgctc ggccacctgc ggcgcctgcc ggacaggaac cggcgcacgg
     2641 cctcggccgc ggagcggtcc gtctccagct ccttgggcgc ctccatgaag atccggttga
     2701 ggttcgtggt cggcgtctgg cagatgaggc gcctcaccag gtacgactcg acgtagagca
     2761 gcgcctcggc ggcgtcctcg ggagtcgtgt cgcccgtgtc caccaggccg aggagatgca
     2821 gggccagcgg gtagtgggtc tggccgcccc acgcggtgag ccgttccagc atcccgcgca
     2881 gtgcgggaga cggctcccgg tgcggctcga tgacgcggag gaaccgcgtg ccccgctcgg
     2941 ccagttcggc gatctcgtgg tgcagcgcct cctcgtcgct cgcgagcggc tggagccgct
     3001 tctgctgctc ccggtagatc tcgctctgct tcgcggtgtg gtgaccccgc acgatcaggt
     3061 ccagccagac gagcagctcc aggttcttgg ggccgaggct ctgctgcatg ggcagccaca
     3121 gctcctggta gacccgctcg ccacggttcc gcaggagtga gaacacgtag ttgcggagca
     3181 ggtcgctctg gctgagcccg acacccgtgt tgttgatcga ctcgaagatg cggtacacgt
     3241 tgtcgccgtg ctcggcggtg atctcgacga tcgacagcag gtccttcagc accgtttcga
     3301 ccgtggccac ccactggtgg ccgtcggcgc cctccctgcc ctcggcgagc acaccgcgga
     3361 agtaccggta cgccccgccg atgctgtcgc cgcctccggc ctgcgggcgg gaccccacgc
     3421 acgaggtgta cgcctcccgg tcggcctgcg tgggcagcag gcggtagtgg tcgaggccct
     3481 cgtggaactc gttgacgagg atctgccgat gcacacggtc ggcggcacgc gggtcgccgc
     3541 actccttgta gtgatcgcgt aacgcggtga acgccagcat cagcgtggtc aaccgctgtt
     3601 ggccgtccac gacgagccac ctctgcacac cgcccgcctg gagccggccg ggatcgagca
     3661 cgacggaccc gaggaagtgc ggcgtcgagt cctgcccgga caggtgccgg tccaccagct
     3721 cgccgacgtc ctcccagaga cgccgcagct gttcctcccc ccagctgtac gtccgctgat
     3781 acagcgggac ttggaactgc ttctccccct ggacgagctt gaggaaggtg atctcctggg
     3841 cgcgcatgcg cttcctttcc ggccgggtac cgccgatgtg aggcgatggg tcccggcggc
     3901 agggaaacct tggcagtcgt cgtgaactcg gtcaacgcgg gcccggcggg ccggagtgag
     3961 tggcatgatg cccttcccct ggtgggcggg cagtggccca gacacgtcct tcgcgcgggc
     4021 cggctcaggc cccaggtgat cccggccggg tgatcagccg tcagccgagt tcagccttcc
     4081 aggtcacctc gggtggccga cgaaaggctg cggccggtga cgtccgcggg cacgcggtag
     4141 tactccgcgg ggcgcgcgga tcggcgccca gcatgtgtgc gtacccggac gccgcctcgg
     4201 cgtcgtcgag cagcggctcc agccgtgcgg cgagggccct gcccgcgtcc gcgacgcccc
     4261 gcgctttcgg cccggcgtcc accagcacct gcaccgcgat gagcagcgcc gtggtccgag
     4321 ggccgtaccg gttcccttga agcgcaccgc gacgccgtcc ctggcgtccc gcaggcccgc
     4381 cgggtgcggc ccgacctgac ggggcccggt ggtggcgggc cgggcgtcag tggcgggcgg
     4441 tgtggccgag gatcgccgcc gtcagcgggg caaggacctc gtgaggcagt gcgtgcccca
     4501 tcccggggat ctccgtcaga cgcgccccgc ggatcacctg tgcgaggtgc tgcgggtgcg
     4561 gaggcggaaa gagaggatcg gccggggcgg cgacgacgag cgtgggtacg tccgtcgcgg
     4621 cgagctgctc ggtgcgcagc atgtccgcag cgtcggcgcg ggcgtgagcg gtgcctgcgg
     4681 tgtggtggcc ggtgtgctcg atgaccctcc gttccgagtc acgggtggcc tcggcgtcga
     4741 aggggagccc gtcgcccccc agcgcgcgcc agtgctcgac ccgacggtcc aactcggctt
     4801 ccaggccgtg gtcctcgacg ggccgggccc acagctccag gatgtgcggg gcgatgccgg
     4861 gcagttcctc gggcggtacg cgggtcccgt ccggacggac gtagggcgcg gtgctgaggg
     4921 cgctcgttcc gagcagggtg gcgctgagca tgcgctccgg gtggtcggcg atgagcagct
     4981 gggtgagcat tcctcccatg gacatcccca cgacgtgggc gcgtgcgaca ccgaaggcgt
     5041 ccagcacggc gatggcgtcg tgggccagct cggtgagggc gtacggcgcc tcgtcgaacg
     5101 cccacgtgga gcggccggtg tcccggtggt cgtagcggat cacccggtgc cggacggcga
     5161 gtgcgtcgac cagttcgtcc ggccagccga gaccggacgc ctgcgcgccc atgatcagca
     5221 gcaggggagg ggcgtcgacg gcgccacgct cctccgccca caggcggact tcgggtgtca
     5281 cgtcgatgaa gcgctccatg gtgccctccg aaaggccgtt gcaggcgata cgagacggtc
     5341 cgtctcgttg tgttttcact ctaacccatg gcgccgcggc gtggcggccc gccacgtgat
     5401 tcaccctcca catccggcgg ccgacgactg accggccgga ccgtgatccg cttcgaacgc
     5461 ggacgccgtg caggcgcgtt ccttgggtag gttgggggcc cgtctcgtcg ctcccgcgca
     5521 atccggaggc cccgcgtgaa caaccagcag cccccatccg ccgacacccg ggacaccgtc
     5581 cccgcggcgt accgtgtcga catcacgcgg ccccactccg ccaggttctg gaactacttc
     5641 gtgggtggca gggacaatta cgaggtcgac cgtgcgatcg gggaccagat caaggcgttc
     5701 ttccccggac tcgtcgatgt cgccgtggcc gggcggcagt tcctgcgcag gtcggtgacg
     5761 cacctggtcc aggagcgggg ggtgcggcag ttcctcgaca tcggcaccgg gctgcccagc
     5821 gccgacaaca cgcaccaggt cgcccagtcc ctcgcccccg agtcgcgcat cgtctacgtc
     5881 gacaacgatc cgctggtcct cacccatgcc agggccctgc tcagcagtac gcgcgaaggg
     5941 gcaaccgact acatcgacgc cgacctctac gacccggcgg cgatcctcgc cgcagccggg
     6001 gacaccctgg acttcgaccg gccggtggcg ctcatgctcc tcgggatcct cggccacgcc
     6061 gacgacttcg gccgtgcccg cgacgtcgta cgggagttga tggccggtct gccgtccggc
     6121 agctacctgg ccgtgtacga cggcacacgg accagcgcgg gcatgatcgc cgcggaggag
     6181 gcgtacatcg agagcggggc cgtgccgtac tacgtccgtg agcccgatga gatcgtcacg
     6241 ctgttcgacg ggctgcgtat gctcgacccc ggcttcgtac ggctcagcga gtggtggccg
     6301 gacgccgact ccgcgcaggt gcccgccgac gtggacgcct acggcggggt cgggatgaag
     6361 gaatagcccg cacacccggg gtggagcggg gcgtggaggg gtggcggaac gaaggtggca
     6421 caggacatga gcgggaacag ggcggcggcg acgtacggcg tcccggacac ggcaccggaa
     6481 ggcccgcccc ggccgccgct gtccacggcg cggaaggccg tcggttccct ggtctgggcg
     6541 gtggcgctgc ctgcggtcat catcctgggc gccggtctcg gccagtggat gacctggctc
     6601 ggcgtcgtcg tcatgctggg tgccgtcgcg gtcgccgcct gcctgatcgg cggtgtctgg
     6661 caccgcgccg gcgcggccac gctcgcctcg gtcgcgggtt tcggcctgat gctgttcgcg
     6721 gggcccgccg tctacgaggt ctacatgaag accgtgggcg atccggtggc cgccgtggtc
     6781 accgaggtga ccgatcgtca gcagcggcgt ggccccgaca tgttctgcac cgtcgaggag
     6841 accggcggcg accgcaccag gcacgaggtc tcgcaacagg agaactgctt cggccaggca
     6901 gcggtgggcg accgggtcga gatccgcaag gacccgctcg ggctgttcga cccgcgcctg
     6961 cccgacagcc cggaccagcg gaacaccacc gagatcaccg tcgcggtcac cacgggactc
     7021 gccctgctca ccgcggccgc caccttctac ggagggcagc ggcggcgcgg gtagcgcgtc
     7081 acgtggttgc ctgtgtcccc gtacgcacac cgcgtgccgt cacgtagtcc gacctgctca
     7141 tctcctgggg tccgtgtgcg gaggataccg agcggtgtgg tgacggcagt gatctgcctg
     7201 gtggcgggag cagccgtgac cggctgcacc gacgggggcg cggagaagga acgccccgcc
     7261 gaccaggtgc tggaggagtc gcacgagacg atgaacgcgc tgaagacagt gaccatcgac
     7321 gcttcgacca cgccgacagc gcgctcccct tgaaggtgac cgacaaggag gacgccgaag
     7381 gcgtctacac cttccacgtc gccaccgagg gcaagccgta tctcctcaag gtcgcctacc
     7441 agggtgccga ctaccgcagc acgaccttct tcagcgcctt cgacgcaccg ctgggcgtcc
     7501 ggccaccggc cgacgccgac gtactggaca cgagcgccgc cggccggtga tccggagccg
     7561 gtagccgaat acccggcggg cgcacctggt tcggacaagg ctctgaacag ccggtgagtg
     7621 cccgtcaggc cttgcgggcg accacgcacc acatcggcag ggtgtcgtcc gggacgtccg
     7681 tcggctcggg gcgccagcgg gtcagggtga ccacgccggg ttccaggatc tccagtccct
     7741 cgcagaagcg ctccacctcc tcgcgggtgc gaggcgtggc ggaggcgtgg tcggcggcgc
     7801 gctcgttgta gatgcgcatg gatgcggcca cctcgggggc ggtgacgtcg acggccgggt
     7861 gggagagaac gaggtaactg cccggtgcga ggcggtccag aaggcggcgg gtgatgtccc
     7921 acgggtcctc ggagtccttg atgtactgga ggatcgccac cagcatgagg ccgaccggct
     7981 cgtccaggtc cagggtgcgc gaggccgctt cgaggatcgt gtccacgtcc cgggcgtcgg
     8041 cctgtacgta ggcggtctgt ccgtcgggac cgctgaccag gagcgcccgg gcgtgggaga
     8101 gcacgatcgg gtcgttgtcg acgtagacga cacgagcctc gggaacggcc cgctgggcca
     8161 cctcgtgggt gttgtccgcg gcgggaatgc ccgtaccgac gtcgaggaac tggcggattc
     8221 cggccgccgc gaggtgacgt acggcgcggc cgaggaaggc ccggttggcc cggaccgacg
     8281 gcacgatcgt cgggttcgcc cgggcggcga gctgggccgc ctcctggtcc acctggtagt
     8341 ggtccttgcc gcccagccag acgtcgtaga cgcgggcggg gtgcgcgttc gccggatgcg
     8401 gtgtggactg cgcgtcgtcg ttcatcgttc atcacctcgt gcgcgaggac ggccaggtgg
     8461 gactcgggtt cgatcacggt acccccggga ccttccgatg ctgcccatcg gcgggcggcg
     8521 aggaccggcc cgtcgcccgg ccggtcctcg ccgcctcccg tccacctggg gggtcagccc
     8581 ttcggctggg tgaagcggat gcggttcccg aaggggtcgc ggagaccgca gtcgattccg
     8641 tacgggcggt cggtgggctc gtcggtgaac tcgacgccct tgcccagcag cgtttcgtac
     8701 gtcttttggc agtcggccgt ggtgaagatg agcgagccgc ccatcgcgcc cttggcgacc
     8761 agtgcgcgga cctgctccgc cgtctcctcc gacatcgccg gggggcgcga acaggtcacg
     8821 gagctcaccg gtgagctgag ccaccagtcc cgggtcggtg ctgcgcagat ggccctggaa
     8881 cgcggcctcg tggtcctggt actcgtcggg caggtcctac gagtaccagc cccccagcaa
     8941 ctgcgcgagc tccgggaagc gggcgcgcca ctcccagtcg gtccgcggcg gtgcgggcgg
     9001 cggggcctga ccggtctcga cgctctcctt gaggcggtcc gcgagcatca gcagccaggc
     9061 ttggatctgc gcgtccggca gccccacatc aggcaggggg cagaactcgc ccaggcgagg
     9121 ccgcagccgc cccggagggt tgcgggcgca ttcacggagc tggaactcgg cgttggcgat
     9181 ggaccagggg cgtgtgcggc aggtgcgacg cagacagtcg gtgatcgcct cctcgtcatc
     9241 ggcggtccgc cccaggtagg cgcggtcgac ctggtccaac tcgccctctg catggtcatg
     9301 ttcgagcggc ttgagggaca cgggtgcctc tagagataga tcgaggcggt ggagtggacg
     9361 gcgcatctgc cggtcccact tgtcgagctc gtccacgaac gtgtcccggg cctccccctc
     9421 ccaggtgagg acgaccttct cggtcctggc gtaaagcgtt tcgagcttct cgttgagctg
     9481 tttgattatg tcctcaagat cgtcggccag atcccgcagg gcggagaaag tgacgcctat
     9541 gtggtcgtcg gacacgcgag gttcctcctg gtgtgttcgt tcagaggtcg tcgaacctgc
     9601 tgcgcggcgg cgcggtgtcc tcggagagct cacgcgcttc tgttgccggt ggccgtgcga
     9661 acgcaccgac cacgtactcc agacagaagg cggccaccag gccggaaatt caggccgtcc
     9721 gggccgggtg accggatgtt gccaggaagc tgtgggccgc cgaaccggcg gggaccagac
     9781 ctgagggccg tatccgactg ggtcgttcgc gggccgaagc ggtggccgtt catacgatca
     9841 gggggtttgg cgctgcccgc atgcggacat cggccgtgct cctgtttcct gacgaggagg
     9901 cgtgggggag gccatgacgg gggcggtgcc gccgcaccgt gtgcctggtt ccggctgccc
     9961 tcccgctcgc tgagcctcga ccagcgtcag gagttgcacc atgccatctt ctgggatcga
    10021 tctcgctgta ttcccccgtc tccaggccga cttggacagg gtccgtgacg ccttcgggcc
    10081 ggtgcgcgtc cacggccggc ccgagctcga cgcgctcacg cacgaagaga ccggcgcctc
    10141 ccgaggcctg gtccgtccca ccctcgctct cctctcgtac tacgtcctca ccgatccttc
    10201 ggagccggcc gacgaccgcg ccgtgctcgc cgccgcagcc gcggagctgc tgcacctggg
    10261 cgcgctctac cacgacgacg tcatggacca cgcctacgag cgccggggcc gccccagcgc
    10321 caacgcactg tggggccagc acctcgccat cctcgcgggg gactgcgtga tgctctcggg
    10381 cctgggcatg ctggcggagc tgggccggcg cgaagtcgcc gagggggtcg cggcgagtga
    10441 acggatgtgc gccgggatgg tgcgggaatc ggccgacctg cacgcggcgt cgcgcagtga
    10501 ggagtcctac ctccaggcgg tcggcggcaa gacggcggag ctgttcgccc tggcctgccg
    10561 actgggggcg atgcaggcga acggcaacgg cggccgtcag gaggacggcc gggaagaggc
    10621 cctcgccggg ttcgggtggc agctcgggca cgcctaccag ttacgcgatg acatcctcga
    10681 cctgacgtcc acggccgagg agttgggcaa gccggtcaac acggatctcg ccgagggcgt
    10741 ctacaccctc cccgtgatcc gcgcggtctc ccgtgaccag ggcctcgccc ggctgctggg
    10801 caaggagctg acgcaggagg aagccgcacg tgcccggggc ctcgtactcg cctcgggcgc
    10861 ggtggaggag acgcaggcgg tcgccgacgc ctacgtggtg agagcggcgg accggctctc
    10921 caccctgacg gaccaccccc gtgccctgga cgagctgaag tcgtacgccc gcactctgct
    10981 tcgcgggcgc ggcgcccgcg ccgccgtggt cccccgccag gcccggcagg agtcacaggc
    11041 ccgagcaggc gcacacgggg agcaggtcac ccggtgggtg aagaactggc tcgtggagac
    11101 cggcctggcg gccaccccgg cggaggccga ccaccaccga ctgtccgggg ccatgtggat
    11161 gatcgagcgg atcctccccc aggcggcggg tgcgcctgcc gacggggagg gcggtgacga
    11221 cgactcctcc gcgaggaagc gggccaccgc tgccatgggc acgctgatct gtgtctggga
    11281 cgacatcttc gaggacccgc tgctgacgag tccacgtgcc gtcaccgagc tgcgggagga
    11341 cctggtggcg accttgcgcc aggaccctgc cgcaccgtgg acgcacgggg cgatcccgac
    11401 ggcgtgggcg cggttgtggc cgcgtctgcg cgcaggcagg acggcgcggt ggcaggaggc
    11461 gttcctcgac agcatcgagc agaccttcca cgcctgcgag cgtgaggcgc accaccgcat
    11521 cagcggtcac atcccctcga cgggggacta cctcccgctg cggaggtcga ccagcgggtt
    11581 cgagatcggc atggggtgct cggaggtcct ccagaaccgg gagatccccc cgacgctgcg
    11641 cggccaccgg atggtccgac ggctcgaaga actggccttc ttcgtcatct tcgccgagaa
    11701 cgacctggcg ggactggacc aggacgaggc tgacgggatc ccctacaacc tggtcagggt
    11761 gatccgccac gagaccggat gcggccgcgc ggaggccgtc gagcgggtgg agcgccaagt
    11821 ggccgagaaa cgagcccagt acaacgcgat cctcacctac gtgcccgtgc tcttccgcac
    11881 gctgcccggc ctctccggcg acagtgacgg gtacgcggcg atctacgacc ggttgaagct
    11941 gttcgtcgat gtgcggcagc gcgggtccga acggtaccgg ccgaacaccc tggccgtggg
    12001 gccggacctg gagcggctgc gccgggagat cagccgacgg ccggccgccc cggtgtcctc
    12061 cgagcgctag tccggcgcgt ggagggagat tcgccgcagg tgccggccgt cctcactcca
    12121 tcccgcgttt gcccggtgcc cagaacggct cggtgaggac cgcccgccgg tcccagcccg
    12181 ctcccggtcc tggcgaccca ctgcacctgt cccggggcga ggccgaggag accggcctca
    12241 acgccgccct cttcgccctc cccgcagtcg ttgcctggct ctccggcacc tggtgagcgt
    12301 gcgcgggggg cgtcgcaggc ccccggggag tcaggcgacc ggggacagct tcttcgccgt
    12361 actgcagtgc ttcgtccgcg cgtgacgcca caactgcacc gtggtcaggg cgagcagcgc
    12421 ggcgaacacg acgaggaaga cggccgtgat caccgtctgc cgggcgcccg ccgccgtgtc
    12481 gtcgtaggag agcaggccga gggcggacag cagcatcccc gccacgtaca ccgagcggac
    12541 gcgccgcagc tgccgcaccg cacgaggagc aagagcaaca cgcttcacga gagccatgct
    12601 cacctcctta ccccctccac ggcggatgag acgtcgactt tcccggtgag tgcgtgccca
    12661 cccaggctcg ctccggccgt gacgtgagtc acaccggtcc catgtcacgg atcgggccgc
    12721 tgctcccatc ccatgcgcgt cgagaccccg cgagtggaag tggaagaggg ccgagcgatg
    12781 aacacacagc acgagacggg tacgggggcg ggaaccgccc accgcgtcct ggtcctgggg
    12841 gccggatacg ccgggatcgc ggcggccgtc cagctcgcgg cgcggaccgc gcggcgcacg
    12901 gacgtggcgg tgaccgtggt cgacgcgcag gagcggttca ccgagcggct gcggctgcac
    12961 atgacggcga ccggacagca gctcgcggag ctgagcgtcc ccgcgctgct ggagggcacg
    13021 ggtgcgcggt tcgtacgcgg ctgggtcacc tcggtcgacg cggacgcgag gacggtccgc
    13081 ctcgacgacg aacgctgcct gtgctacgac acgctcgtgt acgcgctggg cggcgtcgcc
    13141 gacacggcgg ctgtgcccgg ggccggggaa cacgcgtaca ccctgaacgg cacccaggac
    13201 gcccaggtgc tggccgagcg gctggaccgg ctcggcggcg gcaccgtggt ggtctgcggc
    13261 aacggcccca ccggcatcga ggcggcggcc gagatcgccg aacggcaccc ggagctgggc
    13321 gtcgtcctgc tgggccgccg ggaacccggc acggccttgc acccgcgggc cggggcgtac
    13381 ctgcgcggcg cgctggaccg gctgggcgtc caggtgcgcg gcggcacgac cgtggtcggg
    13441 atacggcccg gcgcggtgga gacggcggac ggcgggagca tcgccgccga cgttgtcctg
    13501 tgggccgggg gcacgcgcgt gtcaccgatc gccgccgccg caggactggc cgtcgacgca
    13561 cgcggccgcg tcgtcaccga cgaaaccctg cggtcggtgt cccacccgca ggtgtacgcg
    13621 gtgggcgacg cggcggcgat ccgccagggt tacggcgtca tgcacggcac ctgccagggc
    13681 ggcatgccct cgggggtcca cgccgccgtg tcgatcgtgc gcgcgctgcg gggcaagcag
    13741 ccgaagccgt tccgtttcgg ctattaccac acgccggtga gcctcggacg gcacgacggc
    13801 gtcgtccagt tcacgcatcc ggacgacagt ccccggcgga tctatctgac cggccgcgcc
    13861 gccgcccggt acaaagaggt ggtgaccgcc tcaccctggc cgacgtacgg ccgaatgaag
    13921 aagatgcccg cgtcgggcgc gttctggccg cgcggtggcc gctccacccg ggtgaggggc
    13981 ggcgtgcgat gacacaacag cctgagcagg cagacccgtt ggtgttccag cggcaccggt
    14041 ccctgctctt ctcggtggcc taccgcatcc tcggctcggc ggccgacgcg gaggacgcgg
    14101 tccaggacgc ctggatcaag tggtcggccg ccgaccgctc gcaggtggcg gaccccaggg
    14161 cgtatctggc gcggatcgtg tcgaacctcg ccctggaacg cctgcggtcc acccggaaca
    14221 agcgggagac ctatgtgggc ccctggctcc ccgaacccat cctcaccggc gcggagaacg
    14281 ccggtggcat cgggagcacg gggaacacgg ggaacgcctg gagtacggcc accgccgacg
    14341 ccgccgatac cgtcgtgaac gccgaatccg tgtcgatggc gatgctggtg gtgctggaga
    14401 cgctgagccc gctggaacgc gcggtgttcg tgctgaagga ggtcttcggg ttcagtcacg
    14461 ccgagatcgc ggagaccgtg gagcgctccg aggccgcggt gcgccaggcc gcccaccggg
    14521 cccgtgagca cgtacgggcc ggacggccgc gcttcccggc cgaccggtcg cggcagcgcg
    14581 aggtcaccga gcgcttcctc gccgccgcca ccggaggcga cgtcaacgct ctgatggaac
    14641 tgctgtcccc ggacgtcacc ctgtggaccg acggcggcgg caaggtccgc caggccctgc
    14701 gtccggtcgt gggcgcacag acggtggcgg cctggttcgc ggccatcggc accgtcagct
    14761 accagggcgt cgagcccacc gacatgcacg cggagctcgt cgagatcaac ggtggcccgg
    14821 ggctgctctt cagtgccccg gggcggccgg tcgccacggt caccttcgac ttcgacgcgg
    14881 agggcagcat caccgccgtc cacaacgtgg ccaaccccga caagctccgg gcggtcgcgg
    14941 agggcaccac tcacgacgta cgagtccggt gagaggaggc gggccgctgc cccggcgtcg
    15001 cgggcggctc gacggacggc ccgtcaggag tccggcaact cgaccgtctc gaccgattcc
    15061 tccgccgtcg gcgggagaac ggtgggcagc ccgtggggcg gggtgggccg gtcgtcgacc
    15121 tgtcccgtct ccgcgtccac gtacaccggc accacgtcca cggtcaccgg agccccggca
    15181 gccgtcaccg gggcgctcgc cacgggaacg aaccactgcg cacgccacgc cccgtcgcgc
    15241 cggaccgcca gcagctccac ggcccccgac accgccccgg ggtagtacgc ggccgcggcg
    15301 gccagagccc gcttctcgct cactctgcgc ggcgggaacg tggtgggcgc gtccttcacg
    15361 tgccgcgcca gcagtgccgc gacgcggccc tcccggtcga tccggacgtc cagccgggtc
    15421 ggcgccacca caccgtcggt gttcccccgc cacgcgacca cccagccgga ctccgcccga
    15481 gccccgacgg gtgtggacgt ggcgatggtc ccggacaggg cccaggggaa tcgttcctcc
    15541 gcgtacgagg tggccgtgcg cagggcgtcg tcggcgttcc tgggtcccgc cgcccccgcc
    15601 accgggaagc cggccggacc gggctgctcc ggcggcgtcg agaagtcggc cgagaacacc
    15661 tccccgtccg gcccgctcag ctccgcggat cctgtctcca gggcgatgag gagtgtgtcg
    15721 gctcctccgt cccagccggg catgacctgg acgttcacga tgcgctcgtg gtcaccgaag
    15781 gcggccgtga ccgcctgccg tgccgcctcc cgctccgctc ctcccgcgag ccgcaggctg
    15841 gtcgggtcga cggccaccgg agtgatccag caactcccca cgacgccgca gaccaggatc
    15901 cccgagccga aggcgagcag cgtgggcctg agagcggacg tcaggggccg gagcccaccg
    15961 cggaaggccc ggaccgacgc cgcaccggcg agggccccca gcgccgcgcc cagcacgttc
    16021 atctgtacat cgctggagtc gcaggaccgc ccgatccagg gaagcagccc ctggcacagt
    16081 tcggtgacca cggacagcga cgacgccccc aggaacacgg ggacgacgcg ccggacggcc
    16141 aggacgccga ggaaccccac gaccaggaac atcgccagat tgagcagccc ttgctccgtc
    16201 gcgaagggct cacccaggtc ccggacgacg acgcaccggc gggattcgcc gcctgccgag
    16261 ggcagaagca gcgtgacgcc cacctcggcc gtgagcgcgg ccgccagccc ggcgtaggac
    16321 caggggcgcc tggtgtgctt ccgcgccccg agatatgcca ggagagccgc ggccgacacg
    16381 gcccccgcgg cgaccaggac gaacgcgccc tgatccttga agacggcttc gagcatgagt
    16441 gggcaacacc tttgacagga agtcagtccc gacacgcggg tcaacaaggt cgaccagcgg
    16501 ggccgttcac cggggaggag tcgcaggccg gaccccctgg aaggggatgc gcacccgctc
    16561 cgcgcggttc ccgcaggcgc cggccggggt acggacgtgt gggttccgtc gcccgtacgg
    16621 gggtgtggac gggtgacgaa cgtgtgatcc cgggcaccag aagggctgac cgtcccccga
    16681 ccccgtgagg agccgaccgt ggccctggtg cagctcgacc ttccccaccc gacggcgatg
    16741 cgcgggcgct gggcggcgct cgccgcggtc caggcagcct cggggcgcgg cgagcggtgc
    16801 caggcgcact ggccgctctg gcactacgac gacgggcacg gcagctgggc cgacctgcac
    16861 catctcgacg aggggcgcgc ggtgctgctc gggcaggacc ggaacgactc ggagacgtac
    16921 tacgccgagg ccgccgactt cttcgaggag aaggagaccg acctgctggc cggagccccc
    16981 gcgtggtggg agccgcccgt gcgacgggtc cgggacgcgg acgccgacct cttcctcgcc
    17041 ttcgtctacg gcttcgacgg cacggcctgg tggcgggccc cgtacgacgc cgaggacggg
    17101 ttcggcagcg tgggactgcc cgccctcgac gacgaccgca cccgcgcggc gatcagggcc
    17161 gccaccgggc acgcccccga cggcgacgag ccgccccggg ccgccctcga cacgctgatc
    17221 gccgcggacg gagaggtcga cgaagcgctt ctggccgcgg tcgtaccccc gtccgacacg
    17281 gacgtggcgg tgggtgcggc ggcggcccgg gggttcctgg cccgctgacc ccggcgatcc
    17341 cgctgatccc ggtgcgttcg gtgcgtggtg ctcggcgtgc cgaacggagc cggtcacgga
    17401 cgggagcgga cggctgccgg ggcgcgtgtc cacgccccgg cagcttccgt cgggggtcag
    17461 gtcgtcgacg gcttcccggc cgacgacttc tgggccgacg acttgtggtc cgacggcctc
    17521 tcgcgcaggg cgtcgacgac cgcgcgctcc aggaccgccg actcgctgag cggggtgccc
    17581 ttcctgccca tggtgctgtc cctgatgagg tagctccggt cgcccaggta ctccagggtg
    17641 gtcgagtcga agatccagac ggtgcgccag ccggaccggg tgttgtcgcg ggccacaccg
    17701 atcccgtgcc ggccggccgc gtccaccgcg tcggagtcca cggtcacgcc ggggatcttc
    17761 gccgccgcct tgtagagggc cgccgcggtc ttcggcggca tcaccgtctc catcagcagc
    17821 tgaccgatgg cgtcgaaggt gtcctgggcc cggtcacggt cctcggccgg ggtgtcgcgc
    17881 gcgtcctggt cccgggtgat ctcggtgtcg agccgccgga gcaggacgtc ggcgtcggtg
    17941 ggcagcgagg ccagccaggc gtacgtcggg cggttgaggc ccgccgggta gccgacaggg
    18001 gtctcaccgt ccgggacccc gacggtgatc gggaagtacg agccgtcctg atggatcagg
    18061 ccctcgtcga tcaccggccc cggctcctgc gacatccaga cctcgcgctc gccgggctcg
    18121 gacagcttca ccgggccgcc gtattcgccc tcgttcccgg cctgcagtgt cttgacgtac
    18181 acgaactggt cgcctgtgac cgcctgttcg tcgctcttct cggcgaccga ggcgatccgg
    18241 tcgagcagta cggccgcgcg cggggccgtg gcctgggagg acgtgcccgc gggggacggt
    18301 gccggagtgc tgtcctggcc ggtcacggcg atcgtggtga gcagcactcc gcccagggcc
    18361 agccccgcgg cgggcagcag gacggcgggg cgcgggaggc gggggcgtgc ggtggcgcgg
    18421 tcgccgtcct ggtcgatcag acgcatcagg gtgtccttgt ggtgaagatg acggcccggg
    18481 ggcaggtccc gttcggccgg ggccggcagc agccgggcca gttcctcgtg ttcggcccgc
    18541 tcggggccgg aggtacggtc gttcatcggg cttcctcctg gatgggcagg gccacgaacg
    18601 cggccctgct ctctacctct ccgcggccgg agcggggttc ccggccggat cggaccacct
    18661 ctcccggtcg cgctccccgc acggccccgt ccggctcctg gccgagctcc tcgtcggtga
    18721 gccggcgcag ccgggtacgg gcacgggaca gccgtgaccg tacggtgccg accgggacgc
    18781 ccagcgcctc ggcggcctcg gcgtagtcca gcccggacca gacgcagagg accagcacct
    18841 cgcgttcctg gcggcggagc ccgcccagcg cacgctggac cgcggcgagc cgccgtacgt
    18901 cgtcgacacg ccccgccgtg gcgtccgcga tgtccgccac cggttccggg gcggggcggc
    18961 gggccaggaa ggccaggcgc cgcccgatgc cgcggttggc gttgcgcgcc ttgttcgtgg
    19021 cgatccccag caaccacggc cgcagcgagt cgccctccgg ttccacggag cggcgggtac
    19081 gccaggccgc caggaaggtg tcggacagca cttcctcggc cgtcgaccag tcgccggtca
    19141 gccggtaggc gtggttgtag accgcccgcg cgtactcctc gtagagcgcg gcgaacgcct
    19201 cgcggtcgcc cgccctgatc cgtgcccgca tgcgctcccg atctccctgt tcatcacagc
    19261 tcacaccacc tacctctccg gccgagccga ggggttccgg tgacccgcgc cacactgcgg
    19321 ggcggccgat ccgtaccgtg ccgactgtgt ccggactgtt cgcaacactt gggcgcggcc
    19381 ggtaccgacc gcctgtggaa cgccctcctc gcccgtgggg gaggggcggg tccggtgagg
    19441 gagaggggcc agatcggccg ttccgtgccc gggagcgctc ttccgggccg gagtgcggca
    19501 acttctgacc ggccggtggc gactgcccga taccgccccc gaccgaagga gagccctcct
    19561 catgaggcgc ggacggcgac ctgctcgtcc accactccaa cgacggccag gacaacggcg
    19621 ccccgaagcc cggcgtcaac ctgccgaacc ggagcagcgg ctggccggcc ggctcggggc
    19681 ggcgctgctc gaaccggacg acggctggct ggacggtctg ccgcgtgcct tcaccggccg
    19741 ccgggtccgg cgcgtaccgc tcgacgaggc ccgccgggcc cgcgggccgc agttcgtgaa
    19801 gccgcccacc gacaagagct tcccggcagc cgtgcacgag accggcgaga ccctgcccac
    19861 accggccggc cacccgcacg acgttctggt gcagatcagt gaagtcgtga tctgggtgcg
    19921 ggagttccgg ctcttcctgc tggacggcga gatccgcacc ggcagccggt gcgcgacctt
    19981 cggccggctc gacgcggcgc ccctggccgg ccatccggac gagggcgtcg tccgcgcgtt
    20041 cgcccgacgg ctgatggggg agtgcggcgc caccctgccg agcggggtcg tcgtcgacgt
    20101 cgggctgatg cggtggcgga cggtgacggg cccgagcggt gtgggcggtg gtcgaggcca
    20161 acatggcctg gttcagcaac gtgtacgccg ccgaccccgt ccgtgccctc gacctcgtcc
    20221 tccgctcggc gggcccggcg gccgacctcc gtgccccgga cgcccgtttc cgccggaggt
    20281 gacgcgtcac gcgtccgcga gaggcgtggc cccggcagcg gcatcccgca cggcaacctt
    20341 tccggccgtc gcggcgacta ccgcccgaac cccacctccc ccgagcggac ggaccaggcc
    20401 atggcagtga cccgacgacg acgcaccccg cacggccccg cccggaaccg ggccctggtg
    20461 gcgggcgcga ccgccttcct ggccgtcgcc tccctccagg cgttcggacc ggcacccgac
    20521 gcggcggcgg cgaccaccct gacggtcgcc aaggacggca ccgggcagta caccaccgtg
    20581 caggcggcgg tgaacgcgat ccccgcgggc aacaccgcgc gcgtcgtcgt ctccatcagg
    20641 cccggcacct accgggagac ggtgaagatc ccgtcgaaca agcagaacgt caccctccag
    20701 ggcagcggct ccagccgcaa ggacaccgtc atcgtccacg ccaacgcctc cggcacgccc
    20761 aagcccgacg gctccggcac ctacggcacg agcggcagcg ccaccgtcgc ggccgaggcc
    20821 gacggcttcc aggcccgcaa cctcaccatc tccaacgact tcgacgaggc cgcgcaccag
    20881 gacatggccg accgccaggc ggtcgccctg cgcaccgccg cggacaaggt gttcctcgac
    20941 tccgtcatcg tcaccggcga ccaggacacg ctgctgctcg acaccgcgtc caaggcggcg
    21001 ctcggccgcg tctacatggt gaactcctat gtcgtcggca acgtcgactt catcttcggg
    21061 agggccagcg cggtcatcga ccggtcggtc atcaccctga agaagcgctg ggacggcagc
    21121 tcggccgggt acgtcaccgc gcccagcacg gccgccggcc gcaagggctt cctgatcacc
    21181 gcctcgaccg tgaacggaga cgtcgcggcg gccgccttcc acctcggccg gccctggcac
    21241 gccggcgggg acgcgtccct ggaccccatg gccaccttcc gggacaccac gctcggcgcg
    21301 ggcgtcaagt ccgccccgtg gaccgacatg agcggcttct cgtggaagga cgaccgcttc
    21361 gccgagtaca ggaacaccgg acccggctcg ggcccggcga gcagcgagcg gccgcagctc
    21421 accgactccc aggccgcggc acaggagacc gcggactggc tggccggctg gacaccgacg
    21481 gcgtcctgag ccaccgtggg cggcggggcc ggtccggcac accgggtcga agcgcttcga
    21541 ctccaccctg gacagtgccg gtgagcgagt ttaggctccc cggtgtctgt gcatgtcaga
    21601 gtggagaacg gagcggaggc aggcgctgtc gaagcgcttc accggctctc tccccgcccc
    21661 cacgtcaggg agagccgaat ggtcacgctt gccgaggtcg cccagcacgc cggagtctcg
    21721 gcgagcacgg tgagctatgt cctcagcggg aagcggtcga tctccgcctc cacccggaag
    21781 agggtcgaac acagcatcca gcagctcggt taccacccca acgccggggc aagggccctc
    21841 gccagcagcc gcaccaacat catcgcgctg atggtgccgc tccgcacgga catgtacgtg
    21901 ccggtgatga tggagatcgc catcgccgtc gccaccaccg cccgtacaca cggctacgac
    21961 gtgctcctgc tgaccgggga ggagggcccc gcggccgtcc ggcggatcgc cgggagctcg
    22021 ttggccgacg cgatgatcct gatggacgtc gagctgcacg acgaacggct
//
