LOCUS       NC_015953              21053 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. SirexAA-E, complete sequence.
ACCESSION   NC_015953
VERSION     NC_015953.1
KEYWORDS    GSC:MIGS:2.1; RefSeq.
SOURCE      Streptomyces sp. SirexAA-E
  ORGANISM  Streptomyces sp. SirexAA-E
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7414440)
  AUTHORS   Takasuka,T.E., Acheson,J.F., Bianchetti,C.M., Prom,B.M.,
            Bergeman,L.F., Book,A.J., Currie,C.R. and Fox,B.G.
  TITLE     Biochemical properties and atomic resolution structure of a
            proteolytically processed beta-mannanase from cellulolytic
            Streptomyces sp. SirexAA-E
  JOURNAL   PLoS One 9 (4), e94166 (2014)
   PUBMED   24710170
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7414440)
  AUTHORS   Lucas,S., Han,J., Lapidus,A., Cheng,J.-F., Goodwin,L., Pitluck,S.,
            Peters,L., Ovchinnikova,G., Davenport,K., Detter,J.C., Han,C.,
            Tapia,R., Land,M., Hauser,L., Kyrpides,N., Ivanova,N., Pagani,I.,
            Adams,A., Raffa,K., Adams,S., Book,A., Currie,C. and Woyke,T.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Complete sequence of Streptomyces sp. SirexAA-E
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7414440)
  AUTHORS   Lucas,S., Han,J., Lapidus,A., Cheng,J.-F., Goodwin,L., Pitluck,S.,
            Peters,L., Ovchinnikova,G., Davenport,K., Detter,J.C., Han,C.,
            Tapia,R., Land,M., Hauser,L., Kyrpides,N., Ivanova,N., Pagani,I.,
            Adams,A., Raffa,K., Adams,S., Book,A., Currie,C. and Woyke,T.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2011) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B310, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. SirexAA-E
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            environment                       :: Soil, Terrestrial
            num_replicons                     :: 1
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Free living
            trophic_level                     :: Missing
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: Missing
            sequencing_meth                   :: WGS
            assembly                          :: Newbler v. 2.3 (pre-release)
            finishing_strategy                :: Finished
            GOLD Stamp ID                     :: Gi05895
            Funding Program                   :: DOE-GLBRC 2008
            Source of Isolate :: Cameron Currie (currie@bact.wisc.edu)
            Cell Shape                        :: Filament-shaped
            Motility                          :: Nonmotile
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram+
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Finished
            Current Finishing Status          :: Finished
            Assembly Method                   :: Newbler v. 2.3
            Genome Coverage                   :: 30x
            Sequencing Technology             :: 454/Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000177195.2-RS_2024_05_08
            Annotation Date                   :: 05/08/2024 02:12:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,619
            CDSs (total)                      :: 6,532
            Genes (coding)                    :: 6,385
            CDSs (with protein)               :: 6,385
            Genes (RNA)                       :: 87
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 147
            CDSs (without protein)            :: 147
            Pseudo Genes (ambiguous residues) :: 0 of 147
            Pseudo Genes (frameshifted)       :: 61 of 147
            Pseudo Genes (incomplete)         :: 120 of 147
            Pseudo Genes (internal stop)      :: 8 of 147
            Pseudo Genes (multiple problems)  :: 39 of 147
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:50:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2077803
            Orig. end                         :: 2098856
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP002993.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4086644
            Source DNA and organism available from Cameron Currie
            (currie@bact.wisc.edu)
            Contacts: Cameron Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LANL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="9"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11053](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11053)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    940..953
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    complement(1327..1342)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            1373..2062
                     /locus_tag="SACTE_RS09205"
                     /old_locus_tag="SACTE_1869"
     CDS             1373..2062
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452399.1"
                     /locus_tag="SACTE_RS09205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1869"
                     /product="response regulator transcription factor"
                     /protein_id="WP_014045762.1"
                     /transl_table=11
                     /translation="MSIRVIIVDDQAMVRAGFAALLAAQSDIEVVGQAPDGRQGVEVSR
                     RTCPDVVLMDVRMPEMDGLAAARELLSAPAGTDHRPKVLMLTTFDVDDYVYEALRVGAS
                     GFLLKDAPPADLIAAVRVVAAGDALLAPSVTRRLIADFARQRPSGAFRSGPARRLKGLT
                     PRETEVLELVARGLSNQEIAGRLVVAEQTVKTHVSRILAKADLRDRAQAVIFAYESGLV
                     EPGGAEA"
     gene            complement(2138..3157)
                     /locus_tag="SACTE_RS09210"
                     /old_locus_tag="SACTE_1870"
     CDS             complement(2138..3157)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018518380.1"
                     /locus_tag="SACTE_RS09210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1870"
                     /product="aldo/keto reductase"
                     /protein_id="WP_014045763.1"
                     /transl_table=11
                     /translation="MSDSTGRIATAELGRGGPRVGVQGLGCMGISEFYGDTDEAAARDT
                     LDAALEAGVTLFDTADIYGRGANETFLAPFVGAHRAEITLATKFAVQRTDDPEFRAVNN
                     DPAYIRQAVEGSLRRLGTDVIDLYYMHRRDPLVPLADSVGAMAELVRQGKVKQLGLSEV
                     TGAELREAYAVHPIAALQSEWSLFSRDVERSAVPAAVELGVTVVPYSPLGRGFLTGAFA
                     DAAKDLTADDFRKHQPRFTGENARTNAALLEPVHKIAAAHGVTAAQVALAWVQQRADVH
                     GVAVVPIPGTRKRSRLLENVAATRLTLSAQELEQLEPIAGQVAGDRYPDMSSTSTARE"
     gene            complement(3162..3614)
                     /locus_tag="SACTE_RS09215"
                     /old_locus_tag="SACTE_1871"
     CDS             complement(3162..3614)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103334.1"
                     /locus_tag="SACTE_RS09215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1871"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_026359000.1"
                     /transl_table=11
                     /translation="MTVMESTTAQTDTCATPKAHPRPGGEDRYTISEVAAFTGLSAHTL
                     RWYERIGLMPHVDRSHTGQRRFTNRDLDWLAFVGKLRLTGMPVADMVRYAELLREGEHT
                     FEDRQELLEATRRDVRTRIAELQDTLAVLDHKIDFYAGARAASEGV"
     gene            3696..4508
                     /locus_tag="SACTE_RS09220"
                     /old_locus_tag="SACTE_1872"
     CDS             3696..4508
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045765.1"
                     /locus_tag="SACTE_RS09220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1872"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_014045765.1"
                     /transl_table=11
                     /translation="MQSLALIENWPVPTAAAAVVTADGTVTGTHGPTTHRFPLASVTKP
                     LAAYAALVAYEEGAVELDEPAGPEGSTVRHLLAHTSGLAFDEHRVTAPPGTRRLYSNAG
                     FEVLGDHIAKATEIPFPEYVRQAVLEPLGMTATTVDGSPAKDGVSTVDDLVRFAAELQA
                     PRLLDPRTVLEAQTVVHPGLKGVLPGYGHQNPNDWGLGFEIRGSKSPHWTGSSSSPATF
                     GHFGQSGTFLWVDPAAGAACVALTDRAFGPWATEVWPPFTDAVLAELA"
     gene            complement(<4598..4945)
                     /locus_tag="SACTE_RS33040"
                     /old_locus_tag="SACTE_1873"
                     /pseudo=""
     CDS             complement(<4598..4945)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="SACTE_RS33040"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1873"
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNHVSPTRTGDAATGTEVFYRSEFAMGEHSAGHLRHILRLYLKGS
                     GLLELGDAAELALTELIANVVRHVPGRRCQTCIHLWADGVRVEVADQDPRLPRPCADDE
                     LADGGRGLLLVA"
     misc_feature    complement(4936..4951)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    4987..4998
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            5027..5875
                     /locus_tag="SACTE_RS09225"
                     /old_locus_tag="SACTE_1874"
     CDS             5027..5875
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045766.1"
                     /locus_tag="SACTE_RS09225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1874"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_014045766.1"
                     /transl_table=11
                     /translation="MATVQSLDPDASPPDYYGWEPRRLREAANLKQGQLGDIIFCTGSL
                     IGQIGTTRKIPTRDFSERVDAALGTDGLFSRLVGLVLRSQLPAWFQPYADMEAKATYIS
                     TYQAQVVYGLPQTEEYARALPATGMPDDLDGPLAARMERQRILERDHPPLAWAVLDEAV
                     LHRPIGGRETMRNQLARLLEFAGHRWMRMQVLPFRAGEHTSMDGMFTLLRFEDDPDVIY
                     TEDLISGHMTASLDTIKEAARHYAHLQAAALSVEYSAALIARVMKERYGDRPRPDERTV
                     A"
     gene            5835..6101
                     /locus_tag="SACTE_RS09230"
                     /old_locus_tag="SACTE_1875"
     CDS             5835..6101
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577034.1"
                     /locus_tag="SACTE_RS09230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1875"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_014045767.1"
                     /transl_table=11
                     /translation="METGLGLMNAQWRRSSYSGSTGGECVECTVTGNAAWRTSSYSGNT
                     GGECVEVADGCPASVPVRDSKNPAGPVLFVSTGAWQAFVDGLR"
     gene            6217..7188
                     /locus_tag="SACTE_RS09235"
                     /old_locus_tag="SACTE_1876"
     CDS             6217..7188
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045768.1"
                     /locus_tag="SACTE_RS09235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1876"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_014045768.1"
                     /transl_table=11
                     /translation="MPVIEVADLVKEFRRPKQQHGSFAAVRTLLTREYTVKRAVDGVSF
                     RIEPGEMVGYLGPNGAGKSTTIKMLTGILVPTSGTVQVAGTTPWRDRARNARQIGVVFG
                     QRSQLWWDLPLRESLWLIGRLYDVPADRFAQKQKQFAELLDLGPFLDTPVRQLSLGQRM
                     RGDLAAAMLYDPSILYLDEPTVGLDVVAKERIRTFVGRLNRESGTTVVLTTHDLDDVEE
                     LCDRIVLIDHGKVAYDGDVDELKARYAPHRELVVQTDHLEGVEGAEVVRREEGKVWLRF
                     DPSVTPPAELVAAVLARHRVTDLSIVEPELESVIHRIYADRR"
     gene            7185..7973
                     /locus_tag="SACTE_RS09240"
                     /old_locus_tag="SACTE_1877"
     CDS             7185..7973
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045769.1"
                     /locus_tag="SACTE_RS09240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1877"
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_014045769.1"
                     /transl_table=11
                     /translation="MKAHLACARMEFRVALTYRSSYLSTFVMMLLQIYLLTVVWSAFYD
                     GREEMDGIPLATMTAYATLSTLQYTLVNPWRSSPIEQRVREGKVAVDLLRPIGFPGQML
                     SGQVGWVSASVPVLLVALPFALLIGAGSAPASVAAGFAYPLALLGALLVSQLLGLLLGM
                     VAFWTLEVSGALMAYRFVAQFFSGALVPLWFMPGPVRAAAQWLPFQATAYTPAAIYLGQ
                     AEGTGILAALGVQCAWVVVLGALAALVWSRARQRVLSQGG"
     gene            7979..8779
                     /locus_tag="SACTE_RS09245"
                     /old_locus_tag="SACTE_1878"
     CDS             7979..8779
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458166.1"
                     /locus_tag="SACTE_RS09245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1878"
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_019992674.1"
                     /transl_table=11
                     /translation="MRALRVYLLLAGAAFRAEFQYRGNLFINILGGLFYQGVGLAFIWA
                     VLDRFGQVGGWGLSEIAFLYGLRLTAHGLWLLPGHQLVHIDEVVIEGEYDRYLIRPVSP
                     LVQLLTRRLRLSALGDLAGGAVLLALASARAPVDWSPGAVGFLLLAVMGGALVEGSLQL
                     AASALAFRMKQVAPIKFAIDMIFSDFGNYPLKIFGTAAGFGLTFVFPLAFVAYLPATVL
                     LDREDELAVPVWLGWGAPVAGVLLMYAAYRFWERQTRSYESSGH"
     gene            complement(8800..9960)
                     /locus_tag="SACTE_RS09250"
                     /old_locus_tag="SACTE_1879"
     CDS             complement(8800..9960)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978298.1"
                     /locus_tag="SACTE_RS09250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1879"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_014045771.1"
                     /transl_table=11
                     /translation="MTYTEASMDALRRTGDELADATVATLFERGEVGTFNTLMRYVSTA
                     GQELPDGLPDVAREYLHTTAAPPAWVDWGEMENARLFFIDNNVHISTALSFASMPACYL
                     VPHVARLLSATHGLDYPSRRMAETGQFTVHLMQPDAFEAGSRFIPAAQKVRLLHASIRH
                     HLKREDRWDTEALGTPICQEDMIGGQMFFSLLVLDSLDRLGIHMTEEGADAYYYAWRVV
                     GAMLGVDQDAVPKDLQAARRFLDLYMVRHMGPSEEGAHLTRQLIDLYEEVVPGTFFDPV
                     VSALIRYLAGDTGADWLGVPRTSWDTLVKAAPHLLGVLETIEDRSPLGAWALDRVGHLT
                     TLLELSSLTRGRIMHYAIPEQLKKEYGVSTAVPRTRRWTPPAPTVA"
     gene            complement(10001..11053)
                     /locus_tag="SACTE_RS09255"
                     /old_locus_tag="SACTE_1880"
     CDS             complement(10001..11053)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957329.1"
                     /locus_tag="SACTE_RS09255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1880"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_019992673.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-36, bitscore:
                     124.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTADGAARSVLKDRVDAVLRGFVDEETALLLAVDAELAPVAEQL
                     RTATAYGKRLRAAFCYWGWRAAGQPDSDALVRAAAAMELVHAAAVVHDDLIDGSALRHG
                     LPTAQFALRAAVSGRRRPAAARSLALLVGDLLMSWAGQLFVSSGLPAAYLSRARPLWAA
                     LARELIAGECLEILRTGAVPDVRDSLKVIRYKTAKYTVEQPLLIGGALAGASPDLREAF
                     SDYGLPLGEAFQLRDDLLGLFGETARTGKANADDITGRRPTVLLAETWSRATPAERKHL
                     KGLLGRRLDEDGLGEVRAIMGRTGAPERVEDMIAQRVRAATAVVEQTRLPADATHALTD
                     LAATAVHRRH"
     gene            complement(11040..11336)
                     /locus_tag="SACTE_RS33645"
                     /old_locus_tag="SACTE_1881"
     CDS             complement(11040..11336)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027208.1"
                     /locus_tag="SACTE_RS33645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1881"
                     /product="hypothetical protein"
                     /protein_id="WP_026359035.1"
                     /transl_table=11
                     /translation="MTHTTGRSGPGDSDAVLLAAGAADWALGGLAAAVEGVRGLLGRAD
                     VRELAEEGRRDLRARGRLALDRLSGATASPAYLEVLARHAAARRAGGGQRDDG"
     gene            11755..12930
                     /locus_tag="SACTE_RS09265"
                     /old_locus_tag="SACTE_1882"
     CDS             11755..12930
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157103.1"
                     /locus_tag="SACTE_RS09265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1882"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_014045774.1"
                     /sec_met_domain="MGT (E-value: 3.1e-45, bitscore: 153.7,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRPAHIAMIGVPAVSHVLPSLAVVRELVARGHRVTYANDPAVA
                     DLIKATGAEFVPVTSVLPVADNNWPDDPIAAMGLFLDDAVQSLPQVRAVYDADPADLYL
                     YDIGAYAARALAESQGRPLVQLSPTFVAWEGYAEEVAAPLWQLPGADEYRARFGRWLAR
                     CGATTTDVETFCGPPSRSLALIPRAMQPYADKVDTGTVTFVGPCFGPRGDEDTWTRPAG
                     ARRVLLVSLGSAYTRQPEFYRNCLAAFGELPGWHVVLQIGRHTDPRELGTVPPGVDVRT
                     WVPQVAVLAEADAFVTHAGMGSSGEGLSAGVPMIAVPQGAEQFMNADRLVELGVARRID
                     TADASAEALRTALLELVDDPDVARRSAELRARARAEGGTARAADLVEDALG"
     gene            13025..13432
                     /locus_tag="SACTE_RS09270"
                     /old_locus_tag="SACTE_1883"
     CDS             13025..13432
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045775.1"
                     /locus_tag="SACTE_RS09270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1883"
                     /product="hypothetical protein"
                     /protein_id="WP_014045775.1"
                     /transl_table=11
                     /translation="MRSREYDLQFRDRAARIRTWGLILLSLAALLWIWCAVLLVMPYEA
                     DTSGRTDYRSPAHCEARLFTDRGTANHGLQEGNYCANERDWPEALAVLGASVPLSTVGV
                     GLFTVGTVTRRMSAHGEAMRELDRLAEGRDG"
     gene            complement(13530..14201)
                     /locus_tag="SACTE_RS09275"
                     /old_locus_tag="SACTE_1884"
     CDS             complement(13530..14201)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577038.1"
                     /locus_tag="SACTE_RS09275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1884"
                     /product="pirin family protein"
                     /protein_id="WP_026358998.1"
                     /transl_table=11
                     /translation="MTDVRRSGDRFRGGDPATGGSAGIETLHAFSFGRFYDPDNLRFGP
                     VLACNEERLAPGAGFDEHPHSHTEIVTWVVEGELTHRDTAGHATVVRAGELQHLSAAGG
                     VRHVERNDGTSPLTFLQFWLAPLEPVGDPSYTHVAGVADATPYVLAEAGATLHVRRQAA
                     GERTAVPDAAGVYAHVVRGGVRLGGEELAAGDSARITRPRGLELVAVRDAEVLVWEFGG
                     V"
     gene            14281..15480
                     /locus_tag="SACTE_RS09280"
                     /old_locus_tag="SACTE_1885"
     CDS             14281..15480
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969379.1"
                     /locus_tag="SACTE_RS09280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1885"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_019992670.1"
                     /transl_table=11
                     /translation="MPRPDPEQPAANDAHRHAATLKRLEQSSGRLAANAIARMDETLPW
                     YRAMPPENRSWIGLVAQAGIAAFTEWFRHPETPQAISTDVFGTAPRELTRAITLRQTVE
                     MVRTTIEVMETAIEEVAAPGDESVLREALLVYAREIAFATAQVYAQAAEARGAWDARLE
                     SLVVNAVLSGEADEGAVSRAAALGWNSPEHVCVVLGTAPDGDSELTVEAIRRAARHAKL
                     QVLTGVLGHRLVVIAGGSDNPLNVAKSLIGPYAAGPVVAGPVVPDLLAATRSAQAAAAG
                     LKACSAWQDAPRPVLSDDLLPERAMAGDPAARDQLVEEIYRPLEEAGSALLETLSVYLE
                     QASSLEGAARMLFVHPNTVRYRLRRVTDVTGWSPSDVRSAFTLRIALILGRLAAADTPS
                     "
     gene            15570..16484
                     /locus_tag="SACTE_RS09285"
                     /old_locus_tag="SACTE_1886"
     CDS             15570..16484
                     /EC_number="2.3.1.39"
                     /GO_function="GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_AT (43-281). E-value: 5.9e-41.
                     Score: 132.7. Matches aSDomain:
                     nrpspksdomains_SACTE_RS09285_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156448.1"
                     /locus_tag="SACTE_RS09285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1886"
                     /product="ACP S-malonyltransferase"
                     /protein_id="WP_014045778.1"
                     /sec_met_domain="PKS_AT (E-value: 6.5e-39, bitscore: 132.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVLVAPGQGAQTPGFLTPWLELPGAADRLAGWSDAIGLDLAHYG
                     TKADADEIRDTAVAQPLLVAAGLLSAAALDAAPDVLAGHSVGEITAAALAGVIDDEAAL
                     RLVRTRGLGMAEAAAVTETGMAALLGGDPAVTVPHLEKLGLTPANVNGGGQIVAAGTAE
                     QIAALAEDKPEGVRRVVPLKVAGAFHTHHMAPAVEKLRAAAGTLTVADPKATYVSNADG
                     KTVATGTEVIARLVGQVANPVRWDLCMETFEELGVTALIEAAPGGTLVGLAKRALPGVK
                     TLALKTPDDLDAARALISEHAGA"
     aSDomain        15699..16412
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SACTE_RS09285_PKS_AT.1"
                     /evalue="5.90E-41"
                     /label="SACTE_RS09285_PKS_AT.1"
                     /locus_tag="SACTE_RS09285"
                     /protein_end="281"
                     /protein_start="43"
                     /score="132.7"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="YGTKADADEIRDTAVAQPLLVAAGLLSAAALDAAPDVLAGHSVGE
                     ITAAALAGVIDDEAALRLVRTRGLGMAEAAAVTETGMAALLGGDPAVTVPHLEKLGLTP
                     ANVNGGGQIVAAGTAEQIAALAEDKPEGVRRVVPLKVAGAFHTHHMAPAVEKLRAAAGT
                     LTVADPKATYVSNADGKTVATGTEVIARLVGQVANPVRWDLCMETFEELGVTALIEAAP
                     GGTLVGLAKRALPGVK"
     CDS_motif       15801..15911
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SACTE_RS09285_0001"
                     /evalue="1.40E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="SACTE_RS09285"
                     /protein_end="114"
                     /protein_start="77"
                     /score="46.0"
                     /tool="antismash"
                     /translation="PDVLAGHSVGEITAAALAGVIDDEAALRLVRTRGLGM"
     gene            16498..17499
                     /locus_tag="SACTE_RS09290"
                     /old_locus_tag="SACTE_1887"
     CDS             16498..17499
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018518372.1"
                     /locus_tag="SACTE_RS09290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1887"
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="WP_014045779.1"
                     /sec_met_domain="fabH (E-value: 2e-108, bitscore: 360.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIKPSQGAPYARIMGVGGYRPTRVVPNEVILETIDSSDEWIRS
                     RSGIATRHWASEEETVAAMSVEAAGKAIADAGIAPEQIGAVVVSTVSHFKQTPAVATEI
                     GHKVGAGKPAAFDISAGCAGFGYGLTLAKGMIVEGSAEYVLVIGVERLSDLTDLEDRAT
                     AFLFGDGAGAVVVGPSKQPAIGPTVWGSEGDKSETIKQTVAWDVFHADRPEKFPAITQE
                     GQAVFRWAVFEMAKVAQQALDAAGIAPEDLDVFIPHQANMRIIDSMVKTLKLPEHVTVA
                     RDVETTGNTSAASIPLAMERLLATGQAKSGDTALIIGFGAGLVYAATVVTLP"
     gene            17564..17812
                     /locus_tag="SACTE_RS09295"
                     /old_locus_tag="SACTE_1888"
     CDS             17564..17812
                     /NRPS_PKS="Domain: PP-binding (11-77). E-value: 2.1e-18.
                     Score: 58.3. Matches aSDomain:
                     nrpspksdomains_SACTE_RS09295_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947868.1"
                     /locus_tag="SACTE_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1888"
                     /product="acyl carrier protein"
                     /protein_id="WP_014045780.1"
                     /sec_met_domain="PP-binding (E-value: 5.2e-17, bitscore:
                     60.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 2.8e-06, bitscore:
                     26.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATQEEIVTGLAEIVNEIAGIPVEDVQLDKSFTDDLDVDSLSMV
                     EVVVAAEERFDVKIPDEDVKNLKTVGDAADYILKHQG"
     aSDomain        17597..17794
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SACTE_RS09295_PP-binding.1"
                     /evalue="2.10E-18"
                     /label="SACTE_RS09295_PP-binding.1"
                     /locus_tag="SACTE_RS09295"
                     /protein_end="77"
                     /protein_start="11"
                     /score="58.3"
                     /tool="antismash"
                     /translation="LAEIVNEIAGIPVEDVQLDKSFTDDLDVDSLSMVEVVVAAEERFD
                     VKIPDEDVKNLKTVGDAADYI"
     gene            17893..19155
                     /gene="fabF"
                     /locus_tag="SACTE_RS09300"
                     /old_locus_tag="SACTE_1889"
     CDS             17893..19155
                     /EC_number="2.3.1.179"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (73-416). E-value:
                     6.8e-48. Score: 155.5. Matches aSDomain:
                     nrpspksdomains_SACTE_RS09300_PKS_KS.1"
                     /codon_start=1
                     /gene="fabF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969375.1"
                     /locus_tag="SACTE_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1889"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="WP_014045781.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.9e-54, bitscore:
                     183.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="FabF (E-value: 2e-185, bitscore: 615.0,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPTNRTVVVTGIGATTPLGGDSASTWEGLMAGRSGIKPLEGERF
                     AELPVRIAALAAVDPGDVLPRPLARKLDRSAQFALIAAREAWADAGYTGKAGEDEKIRP
                     ERLGSVIASGIGGVITLLDQYDVLKDKGVRRVSPHTVPMLMPNGPAANVGLEVNAQAGV
                     HTPVSACASGAEAIGYAVEMIRTGRADVVLAGGTEAAIHPLPIAAFANMMAMSKSNDEP
                     EKASRPYDTARDGFVLGEGAGVVVLESAEHAAARGARVYCEVLGQGLSADSHHIAQPEP
                     TGRGIAAAMQNLLDSTDLKPSEVVHLNAHATSTPQGDVAEVKALRQVLGEDLDHVAISA
                     TKSMTGHLLGGAGGIETVATVLALHHRMAPPTINVDELDEAVDADIVRDKPRPLPEGSI
                     AAINNSFGFGGHNVVLAFRSA"
     aSDomain        18112..19140
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SACTE_RS09300_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.80E-48"
                     /label="SACTE_RS09300_PKS_KS.1"
                     /locus_tag="SACTE_RS09300"
                     /protein_end="416"
                     /protein_start="73"
                     /score="155.5"
                     /tool="antismash"
                     /translation="RSAQFALIAAREAWADAGYTGKAGEDEKIRPERLGSVIASGIGGV
                     ITLLDQYDVLKDKGVRRVSPHTVPMLMPNGPAANVGLEVNAQAGVHTPVSACASGAEAI
                     GYAVEMIRTGRADVVLAGGTEAAIHPLPIAAFANMMAMSKSNDEPEKASRPYDTARDGF
                     VLGEGAGVVVLESAEHAAARGARVYCEVLGQGLSADSHHIAQPEPTGRGIAAAMQNLLD
                     STDLKPSEVVHLNAHATSTPQGDVAEVKALRQVLGEDLDHVAISATKSMTGHLLGGAGG
                     IETVATVLALHHRMAPPTINVDELDEAVDADIVRDKPRPLPEGSIAAINNSFGFGGHNV
                     VLA"
     gene            complement(19234..19728)
                     /locus_tag="SACTE_RS09305"
                     /old_locus_tag="SACTE_1890"
     CDS             complement(19234..19728)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572339.1"
                     /locus_tag="SACTE_RS09305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1890"
                     /product="DUF3145 domain-containing protein"
                     /protein_id="WP_014045782.1"
                     /transl_table=11
                     /translation="MTTRGVLYVHSAPRALCPHVEWAVAGVLGVRVQLDWIRQPAAPGT
                     WRSEFSWQGRVGTAAELASALRGWDMLRFEVTAEPCPTAEGERYSATPGLGIFHAVTGM
                     HGDILVPEDRLRAALARSAGGEADLGAEVARLLGKPWDDELESFRHAGEGAPVRWLHQV
                     V"
     misc_feature    19807..19825
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    complement(19809..19824)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    complement(19838..19852)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.7"
                     /tool="antismash"
     gene            20090..20995
                     /locus_tag="SACTE_RS09310"
                     /old_locus_tag="SACTE_1891"
     CDS             20090..20995
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045783.1"
                     /locus_tag="SACTE_RS09310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SACTE_1891"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_014045783.1"
                     /transl_table=11
                     /translation="MAEGQSRHRVRRAAAALTAVATVGVAVLTGCGGAGDGGSTARPSR
                     SPSPTPAWNASPASVAAVGDSITRGFDACSVLADCPEVSWATGTDDAVRSLALRLLGPS
                     KAASHSWNHAVSGARMAQLPEQMALAAKERPELVTVMIGANDACRDSVELMTPVADFRA
                     SFEASLRQLRAEAPRAQVYVSSVPDLKRLWSTGRENALGKQIWKLGICRSMLGDADDMG
                     AAAVARRDAVQERVVAFNGVLRDVCAKDRHCRYDGGAVFDYRFTGAQLSRWDWFHPGRD
                     GQARLAEIAYRNVTAAGPPA"
ORIGIN
        1 cttcctcttc cccggggtcg cccccgcccg ccgacggtct gccgagcgtc gtccgtcgtc
       61 atctgggcgc actcgcccgc agcctggccc acccctccca cccgccgacc cccctgctcg
      121 ccggcgcctc caggcggtgg cagcggctgg cgccgtacct cgtcgtcacc ctgctcaccg
      181 ccctcttcgt gccggccacg ttccagatcc tgaccatgga ctaccaggtg gggcgcggcc
      241 cggccgcgct cctggcactc gcccaggcag ggccgctgct gatgctggcc caccggccgc
      301 tgcaggcgtg gtggatcgtc ttcggcgcgg acgtggtcgg cgcgctggtg ctgctcgccc
      361 ccgtgtcgtc gcccgccccc gtgccgctcc cacccctgcg tcaggagctc ccctggccgt
      421 ggtcgccgac ggtcgtcatc tcctacctct tcgtgctgct cgccctgggg ctgcgcgaga
      481 cccggcggac cctgctcgcc gtctggctga cgaccggcac ggccgggctg ctgctgtacc
      541 tgatcgcgcc ggagcgcgac gccagcggtg tcgtgctgct gccggtgctg ggcgccgtgg
      601 tcctcgtgat cacggcggcg ctgcgggagc ggggcgaggc gcagcggcgg ctcgtcgagc
      661 aggagacgat cagcgagacc gagcgggccg ggcggacact gctggaggag aggacccgga
      721 tcgcccggga gctgcacgac gtggtcgccc accacatgtc ggtgatcacg gtgcaggcgg
      781 actcggcgcc gtaccggatc agcggcctcc cggaacaggc gcgcgaggag ttcggctcga
      841 tcgcggcgag cgcccgggag tcactgacgg agatgcgacg gctgctctcg gtgctgcgca
      901 gcgacggcac cgagggggag cgggcccctc agccggggct ggaccggatc cagcagctgg
      961 tggaggccac ggtgcggtcg gggctgcccg tggagctgtc gatgggcacg gatgtgccgg
     1021 ggtcgacgga ggacgggctg ccccaggccg tcgacctgtc cgcgtaccgc atcgtgcagg
     1081 aggccctggc caatgtggtc cggcacgcgc cgggggcccg tacccgggtg tcggtcacgg
     1141 cggccggctc ccatctgacg gtcctggtcg tcaacgaccg ggcgcagcgc cccggttcgc
     1201 cgctggaggc gaccggcacg gggcacgggc tggtcgggat gagggaacgc gtacggttga
     1261 ccggcggcac gctggacacc ggtccgctgc ccgacggggg cttccgggtg gccgcgcggc
     1321 tgccgctgtc cgctcccgtc gtttcgtcgg cttccctcgc ctcggaggat ccttgagcat
     1381 ccgcgtgatc atcgttgacg accaggccat ggtcagggcg gggttcgcgg cgctgctcgc
     1441 ggcgcagagc gacatcgagg tggtgggcca ggcaccggac gggcgccagg gcgtcgaggt
     1501 gagccgccgt acgtgcccgg acgtggtcct gatggacgtc cggatgccgg agatggacgg
     1561 gctggcggcg gcccgcgagc tgctgtcggc ccccgcgggg acggaccacc gcccgaaggt
     1621 gctgatgctg accacgttcg acgtggacga ctacgtgtac gaggcgctgc gcgtcggggc
     1681 gtccggcttc ctgctgaagg acgccccgcc ggccgatctg atcgcggcgg tgcgcgtcgt
     1741 ggccgcgggg gacgcgctgc tcgcgccgtc cgtgacccgt cggctgatcg cggacttcgc
     1801 gcgccagcgg ccgtccgggg ccttccggag cggccccgcc cggcggctga aggggctgac
     1861 cccgcgcgag accgaggtgc tggagctggt ggcccggggc ctgtcgaacc aggagatcgc
     1921 gggacggctg gtggtggcgg agcagacggt gaagacccat gtctcgcgga tactcgccaa
     1981 ggcggatctg cgggaccggg cgcaggcggt gatcttcgcg tacgagtcgg gtctggtgga
     2041 gccgggcggc gccgaggcgt agcacctcgg cgccgcccgg cccttcggcc ggaccccgtc
     2101 ccggggcccg gggacgggtc ctggggtcct ggggccgcta ctcgcgggcg gtggacgtgc
     2161 tgctcatgtc cgggtaccgg tcccccgcca cctgcccggc gatcggctcc agctgttcca
     2221 gctcctgcgc gctcagggtc agccgggtcg ccgcgacgtt ctccaggagt cggctgcgct
     2281 tgcgggtccc ggggatcggg accacggcga ccccgtgcac gtcggcacgc tgctgcaccc
     2341 acgcgagggc gacctgggcg gcggtcaccc cgtgcgccgc cgcgatcttg tgaacgggct
     2401 ccagcagcgc ggcgttcgtc ctggcgttct cgccggtgaa gcgcggctgg tgcttgcgga
     2461 agtcgtccgc cgtcaggtcc ttcgccgcgt ccgcgaacgc cccggtcaag aatccccggc
     2521 cgagcggcga gtacggcacg acggtcaccc cgagctcgac ggccgcggga acggcgctgc
     2581 gctccacgtc ccggctgaag agcgaccact ccgactggag cgcggcgatc gggtgcacgg
     2641 cgtacgcctc ccgcagctcc gcgccggtca cctcgctcag cccgagctgc ttcaccttgc
     2701 cctgccgcac cagctcggcc atcgcgccca ccgagtcggc gagcgggacg agcggatcgc
     2761 gccggtgcat gtagtacagg tcgatgacgt cggtgccgag ccgccgcagg ctgccctcga
     2821 cggcctgcct gatgtacgcc gggtcgttgt tcaccgcccg gaactcgggg tcgtccgtcc
     2881 gctggacggc gaacttcgtg gccagggtga tctctgcgcg gtgcgccccg acgaacggcg
     2941 cgaggaaggt ctcgttggcg ccgcgcccgt agatgtcggc ggtgtcgaag agagtgacac
     3001 ccgcctccag tgccgcgtcg agggtgtccc tggccgcggc ctcgtcggtg tccccgtaga
     3061 actcgctgat ccccatgcag ccgagcccct ggacaccgac cctggggccg cccctcccga
     3121 gctccgccgt ggcgatcctg ccggtgctgt cgctcatgtc gtcagacccc ttccgacgcc
     3181 gctcgggcgc ccgcataaaa gtcgatcttg tggtcgagga cggcgagggt gtcctggagc
     3241 tccgcgatcc gcgtcctcac gtcgcggcgg gtcgcctcca gcagctcctg ccggtcctcg
     3301 aaggtgtgct cgccctcgcg cagcagttcc gcgtaccgga ccatgtcggc gaccggcatg
     3361 ccggtcagcc ggagcttgcc gacgaaggcc agccagtcca ggtcgcggtt ggtgaagcgg
     3421 cgctgcccgg tgtgggagcg gtccacgtgc ggcatcaggc cgatccgctc gtaccaccgc
     3481 agggtgtgcg cgctgagacc ggtgaaggcg gcgacctcgc tgatggtgta gcggtcctca
     3541 cccccgggac gcgggtgcgc cttcggggtc gcgcaggtgt cggtctgtgc ggtagtgctc
     3601 tccatcaccg tcatgctctc cacgctagaa ccttggagtg cactcgaagc aagcgcaaac
     3661 gggtgacgtg tccggacggt cgtaagctcg tccccatgca gagcctggca ctgatcgaga
     3721 actggcccgt tcccacggcg gccgccgccg tcgtcaccgc ggacggtacc gtcaccggta
     3781 cgcacggccc gaccacgcac cgtttccccc tcgcctccgt caccaagccg ctggcggcgt
     3841 acgcggcgct ggtggcgtac gaggagggcg cggtggagct ggacgagccg gccgggcccg
     3901 agggctccac ggtccgccac ctgctcgcgc acaccagcgg cctcgccttc gacgagcacc
     3961 gggtgaccgc gcctcccggc acccggcggc tgtactccaa cgcgggcttc gaggtgctgg
     4021 gcgaccacat cgcgaaggcc acggagatcc cgttcccgga gtacgtgcgc caggccgtgc
     4081 tggagccgct gggcatgacg gcgaccacgg tggacggctc cccggccaag gacggcgtct
     4141 ccaccgtgga cgacctggtc cgcttcgccg ccgagctcca ggccccgcgc ctgctggacc
     4201 cgcgcacggt gctggaggcc cagaccgtcg tccaccccgg cctcaagggc gtcctgccgg
     4261 ggtacggcca tcagaacccg aacgactggg gactcggatt cgagatccgt ggctccaagt
     4321 cacctcactg gacgggcagt tcctcctccc ccgcgacctt cggccacttc ggccagtccg
     4381 gtacgttcct gtgggtcgac ccggcggcgg gcgcggcctg cgtcgcactg acggaccggg
     4441 ccttcgggcc ctgggccacg gaggtctggc cgccgttcac ggacgcggta ctggcggagc
     4501 tggcctgacc ggtcttccgg tcggccaggc actcgaacca caccgtcttg ccggttccgt
     4561 cgggccgggg ctccacgccc caccggtcgg tgacggccgc gacgagtagc aagccccgtc
     4621 ctccgtcggc gagttcgtcg tcggcgcagg gccggggcaa tcgcgggtcc tggtccgcga
     4681 cctcgacccg tacgccgtcc gcccagaggt ggatgcacgt ctggcaccgg cggccgggga
     4741 cgtgccgtac gacgttcgcg atcagctcgg tgagcgccag ttcggcggcg tcgcccagtt
     4801 cgagaaggcc ggaacccttg aggtacaggc gcaggatgtg gcgcaggtgt ccggccgagt
     4861 gctcgcccat ggcgaactcc gagcggtaga agacctcggt cccggtcgcg gcgtcaccgg
     4921 tccgggtagg ggatacgtga ttcatgtcac cagggtgcag tggattgatt actctcggct
     4981 acgcaacgaa acgaacgccg caaggtgttg cagccggagg taccccgtgg ccaccgtgca
     5041 gtcactcgac cccgacgctt ccccgccgga ctactacggc tgggaaccgc gccgcctgcg
     5101 cgaggccgcc aacctgaaac agggtcagct cggcgacatc atcttctgca cgggctccct
     5161 gatcggccag atcgggacga cgaggaagat cccgacccgc gacttctcgg agcgggtgga
     5221 cgcggcactc ggcacggacg gactcttctc ccgcctggtc ggcctggtcc tgcgcagcca
     5281 actgccggcg tggttccagc cgtacgcgga catggaggcg aaggcgacgt acatctccac
     5341 ctaccaggcg caggtggtgt acgggctacc gcagacggag gagtacgcgc gggcgctgcc
     5401 ggccacgggc atgccggacg acctcgacgg cccgctggca gcccgcatgg aacgccagcg
     5461 catcctggaa cgggaccatc cgccactggc ctgggcagtc ctggacgagg cggtactgca
     5521 ccggccgatc ggcggccggg aaacgatgcg gaaccaactg gcgcgcctgt tggagttcgc
     5581 gggacaccgc tggatgcgga tgcaggtgct gccgttccgc gcgggtgaac acacaagcat
     5641 ggatggcatg ttcaccctgc tgcgcttcga ggacgacccg gacgtcatct acaccgagga
     5701 cctcatctcc ggtcacatga ccgccagcct ggacaccatc aaggaggctg cgcgccacta
     5761 cgctcatctc caggccgctg ccctctccgt cgagtattcc gcggcactga tcgcccgcgt
     5821 gatgaaggag cgttatggag accggcctcg gcctgatgaa cgcacagtgg cgtaggtcca
     5881 gttacagcgg cagcaccggt ggtgaatgcg tggagtgcac cgtcaccggc aacgccgcct
     5941 ggcgcacatc ctcgtacagc ggaaacaccg gcggcgagtg cgtcgaggtc gccgacggct
     6001 gccccgcctc cgtcccggtc cgcgacagca agaacccggc cggtcccgtc ctgttcgtga
     6061 gcaccggcgc ctggcaggct ttcgtggacg ggctgcgata gacggcgaac ccccgtcgct
     6121 cacaaggtaa ttggttggcc tggaccagcc cgcattgtgc acactcactg atcgaccgtg
     6181 cccctcgggg cttcgcctgg tccaggagag gcgtacatgc ccgtcatcga ggtggcagac
     6241 ctcgtcaagg agttccgcag gcccaagcag cagcacggct cgttcgcggc ggtgcgcaca
     6301 ctgctgaccc gcgagtacac cgtcaagcgc gccgtcgacg gcgtcagctt ccggatcgag
     6361 ccgggcgaga tggtgggcta tctcggcccc aacggtgccg ggaagtccac caccatcaag
     6421 atgctcaccg gcatcctcgt gcccacctcc ggcaccgtcc aggtcgccgg aaccactccc
     6481 tggcgcgacc gtgcccgcaa cgcccgccag ataggcgtgg tcttcggcca gcgcagtcag
     6541 ctctggtggg acctgccact gcgcgaatcg ctgtggctca tcggccggct ctacgacgtg
     6601 cccgccgacc ggttcgcgca gaagcagaag cagttcgccg agctgctgga cctcgggccc
     6661 ttcctcgaca ccccggtgcg ccagctgtcg ctgggccagc ggatgcgcgg cgacctcgcc
     6721 gccgcgatgc tctacgaccc gagcatcctc tacctggacg agccgaccgt cggtctggac
     6781 gtcgtcgcca aggagcggat acgcaccttc gtcggccggc tcaaccgcga gtccggcacc
     6841 acggtcgtcc tcaccaccca cgacctcgac gacgtcgagg aactctgcga ccgcatcgtc
     6901 ctcatcgacc acggcaaggt cgcctacgac ggtgacgtgg acgagctgaa ggcccgatac
     6961 gccccgcacc gggagctcgt cgtgcagacc gatcacctcg aaggggtcga gggcgccgag
     7021 gtcgtacgcc gcgaggaggg caaggtgtgg ctgcgcttcg acccctcggt caccccgccc
     7081 gccgaactgg tcgcagccgt gctggcgcgg caccgggtga ccgacctgtc gatcgtggag
     7141 cccgagctcg aaagcgtcat ccaccggatc tacgcggacc gccggtgaag gcccatctcg
     7201 cgtgtgcccg gatggagttc cgcgtcgcgc tcacctatcg cagctcctac ctgtcgacgt
     7261 tcgtgatgat gctgctccag atctacctgc tgacggtggt gtggagcgcc ttctacgacg
     7321 gccgcgagga gatggacggg atccccctcg ccaccatgac ggcgtacgcg acgctgtcca
     7381 cactccagta cacgctggtc aacccctggc ggtcctcgcc catcgagcag cgggtgcgcg
     7441 agggcaaggt cgcggtggac ctgctgcggc ccatcggctt ccccgggcag atgctgtccg
     7501 gccaggtcgg gtgggtctcc gcgtcggtgc cggtcctgct ggtggcgctg ccgttcgcgc
     7561 tgctgatcgg tgcgggcagt gcccccgcct cggtggccgc cggcttcgcc tatccgctcg
     7621 cgctgctcgg cgcgctgctc gtcagccagc tgctcggact gctgctcggc atggtcgcct
     7681 tctggacctt ggaggtgagc ggggccctca tggcgtaccg cttcgtcgca cagttcttct
     7741 ccggggccct ggtcccgctg tggttcatgc cgggtcccgt cagggccgcc gcacaatggc
     7801 tgccgttcca ggccaccgcg tacaccccgg ccgccatcta cctcggccag gccgagggga
     7861 ccggaatcct cgccgccctg ggcgtgcagt gcgcgtgggt cgtcgtcctc ggcgcgctgg
     7921 ccgcgctggt gtggtcgcgg gcgcggcagc gtgtcctgtc gcagggcggg tgagcggggt
     7981 gcgcgcgctg cgtgtctatc tgctgctggc cggtgcggcg ttccgcgccg agttccagta
     8041 ccggggcaac ctcttcatca acatcctcgg cgggctgttc taccagggcg tggggctggc
     8101 cttcatctgg gcggtcctcg accgcttcgg tcaggtcggc ggctggggcc tgtcggagat
     8161 cgccttcctg tacgggctcc ggctcaccgc ccacggcctg tggctcctcc cgggccatca
     8221 gctggtccac atcgacgagg tcgtcatcga gggcgagtac gaccggtatc tgatcaggcc
     8281 cgtctcgccg ctggtccagc tcctcacccg caggctgcgg ctgagcgcgc tcggcgacct
     8341 cgcgggcggg gcggtgctgc tggccctcgc gtcggccagg gcgccggtcg actggtcgcc
     8401 gggggccgtc ggcttcctgc tgctggccgt catggggggc gcgctggtgg aggggtcact
     8461 ccaactggcg gcgtcggcac tggcgttcag gatgaagcag gtcgccccga tcaagttcgc
     8521 catcgacatg atcttcagcg acttcgggaa ctatccgctg aagatcttcg gtacggccgc
     8581 cggtttcggg ctgaccttcg tcttcccgct ggcgttcgtc gcctacctcc cggccaccgt
     8641 gctgctggac cgcgaggacg aactcgcggt gcccgtgtgg ctgggctggg gcgcgcccgt
     8701 ggccggcgtc ctgctgatgt acgccgccta ccgcttctgg gagcggcaga cccgctccta
     8761 cgagagcagc gggcactgac cggtccggga ggccgccgct caggccaccg tcggggcggg
     8821 cggggtccag cggcgggtgc gggggaccgc ggtggacacc ccgtactcct tcttgagctg
     8881 ttccgggatc gcgtagtgca tgatcctgcc gcgggtgagc gaggacagtt cgaggagggt
     8941 ggtgaggtgg ccgacgcggt ccagggccca ggcgcccagc ggtgagcggt cctcgatggt
     9001 ctccagcacg cccagcaggt ggggcgcggc cttgacgagg gtgtcccagg aggtgcgggg
     9061 cacgccgagc cagtcggcgc cggtgtcgcc cgcgaggtag cggatgaggg cggagacgac
     9121 cgggtcgaag aaggtgccgg ggacgacctc ctcgtacagg tcgatcagct gccgggtcag
     9181 atgggcgccc tcctccgagg ggcccatgtg gcggaccatg tagaggtcga ggaagcggcg
     9241 ggccgcctga agatccttcg gcacggcgtc ctggtcgacg ccgagcatgg cgccgaccac
     9301 ccgccacgcg tagtagtagg cgtccgcgcc ctcctcggtc atgtggatgc ccagccggtc
     9361 cagcgagtcc agcaccagca gggagaagaa catctgcccg ccgatcatgt cctcctggca
     9421 gatcggcgtc cccagcgcct cggtgtccca ccggtcctcc cgcttgaggt ggtggcggat
     9481 ggaggcgtgc agcagccgta ccttctgggc ggcggggatg aagcggctgc cggcctcgaa
     9541 ggcgtcgggc tgcatcaggt ggacggtgaa ctgcccggtc tccgccatcc gcctggaggg
     9601 gtagtccagg ccgtgtgtgg cggacagcag cctggccacg tgcgggacga ggtagcaggc
     9661 gggcatggac gcgaaggaca gggcggtgga gatgtgcacg ttgttgtcga tgaagaacag
     9721 ccgggcgttc tccatctctc cccagtccac ccaggcgggc ggggccgcgg tggtgtgcag
     9781 gtactcccgt gcgacgtcgg gcagtccgtc gggaagctcc tgcccggcgg tggacacgta
     9841 ccgcatgagg gtgttgaacg tgcccacctc gccccgctcg aacagggtcg ccacggtcgc
     9901 gtcggccagc tcgtccccgg tacggcgcag ggcgtccatc gacgcttcgg tgtaggtcat
     9961 cagggtcttc ctccgtgtgg gcggtccggc gggggcacgg tcagtggcgg cggtggaccg
    10021 cggtggcggc caggtcggtc agcgcgtggg tggcgtcggc cggcagccgg gtctgctcca
    10081 cgacggcggt ggcggcccgg acgcgctggg cgatcatgtc ctcgacgcgc tcgggggccc
    10141 cggtgcggcc catgatcgcg cgcacctctc cgaggccgtc ctcgtccagt cggcgcccca
    10201 gcaggccctt gaggtgcttg cgttcggcgg gggtggcccg ggaccaggtc tcggccagca
    10261 ggaccgtggg gcggcggccg gtgatgtcgt cggcgttcgc cttgccggtg cgcgccgtct
    10321 ccccgaacag acccagcagg tcgtcccgca gctggaacgc ctcccccagc ggcagcccgt
    10381 agtcgctgaa ggcctcccgc aggtccggcg aggctccggc cagggctccg ccgatgagca
    10441 ggggctgctc gacggtgtac ttggcggtct tgtagcggat caccttcagt gagtcccgta
    10501 cgtcgggcac cgcgccggtg cgcaggatct ccaggcactc cccggcgatc agctcccgtg
    10561 ccagggcggc ccacagcggg cgggcccggg acaggtaggc ggcgggcagc ccgctggaga
    10621 cgaacagctg cccggcccac gacatcagca gatcccccac cagcagggcc agcgaccggg
    10681 ccgccgccgg acgccgacgg ccggacacgg ccgcacgcag ggcgaactgg gcggtgggca
    10741 ggccgtgccg cagcgcactg ccgtcgatca ggtcgtcatg gaccacggcc gccgcgtgca
    10801 ccagctccat cgcggccgcg gcccggacca gcgcgtcgct gtcgggctgc cccgccgccc
    10861 gccagcccca gtagcagaac gccgcccgca gccgcttgcc gtacgcggtg gcggtacgca
    10921 actgctccgc caccggcgcc agttcggcgt cgacggccag cagcagagct gtctcctcgt
    10981 ccacgaagcc gcgcagcacc gcgtccaccc ggtccttgag gacggagcgc gcggcgccgt
    11041 cagccgtcgt cacgctgtcc accgccggca cggcgggcgg cggcgtgccg ggccaggacc
    11101 tccaggtacg ccggcgaggc ggtggcgccc gacagccggt ccagggcaag ccgcccccgg
    11161 gccctgagat cccgacggcc ctcctcggcc aactcgcgga cgtccgccct gccgagcaga
    11221 cctcgcaccc cctccaccgc ggcggccagg ccgccgaggg cccagtcggc ggctcccgcg
    11281 gccagcagca ccgcgtcgct gtcccccggt ccgcttcgtc ccgtcgtatg cgtcaccgcg
    11341 ttcccctccc gcatcggcga cccggacccg gcccggccgg tgcggtcgcc cctccccggc
    11401 tgttccgacg acagcgtgtc cgggcggagg cggcggtacg cgccggacca ccgatcaggc
    11461 gaacgtctga actggcgttc gccctgctgc gggggacgcg gcgaactgtc gcgggggcgt
    11521 ggcgaactgt gcccctgcgg cgcggcgtta ttccggtgca gtggcggccg gggcagggct
    11581 aaggtgacgg ccgtgtgctt ccttcagatc tacggctgac accggacggg gccatgcccc
    11641 cgctcccgtc gcgcggaccc gtgcgcgccg cctccgtcag ggcttcgccc tcggacggcc
    11701 ggcgcgcggg tccgccgtgt ccctgtgccg cagacctgaa tcgagtgatg tcccatgtcc
    11761 cgtcgccctg cccacatcgc gatgatcggc gtccccgccg tcagccacgt cctgccgagc
    11821 ctcgcggtcg tccgcgagct ggtcgcccga ggccaccggg tgacctacgc caacgacccg
    11881 gccgtggccg acctgatcaa ggccaccggc gccgagttcg tccccgtcac gtccgtgctg
    11941 ccggtggccg acaacaactg gcccgacgac cccatcgcgg cgatgggtct cttcctggac
    12001 gacgcggtcc agtcccttcc gcaggtgcgc gccgtgtacg acgccgaccc ggcggacctg
    12061 tacctgtacg acatcggggc gtacgccgcg cgggcgctcg ccgagtcgca gggccgtccg
    12121 ctcgtacagc tctcgccgac cttcgtggcc tgggagggat acgccgagga ggtcgcggcc
    12181 ccgctttggc agctgccggg cgccgacgag taccgggcga ggttcggccg gtggctcgcg
    12241 cggtgcgggg cgaccacgac ggatgtggag accttctgcg ggcccccgtc ccgttccctc
    12301 gccctgatcc ccagagcgat gcagccgtac gccgacaagg tcgacaccgg cacggtcacg
    12361 ttcgtcgggc cgtgcttcgg cccccggggc gacgaggaca cctggacacg gcccgccggc
    12421 gcccggcgcg tgctcctggt ctccctggga tcggcgtaca cccggcagcc ggagttctac
    12481 cgcaactgcc tggccgcctt cggcgaactg cccggctggc acgtcgtgct ccagatcggc
    12541 aggcacaccg acccgcggga actgggcacc gtcccgcccg gcgtcgacgt gcgcacctgg
    12601 gtaccgcagg tggcggtcct ggcggaggcc gacgccttcg tcacccacgc gggtatgggc
    12661 agcagcggtg agggtctgtc cgccggggtc ccgatgatcg ccgtaccaca gggggccgag
    12721 cagttcatga acgcggaccg tctcgtcgaa ctgggcgtgg cccgccgcat cgacaccgca
    12781 gacgcctcgg ccgaggccct gcggaccgcc ttgctggagc tggtcgacga tccggacgtc
    12841 gcccgccggt ccgcggagct ccgggcgcgg gcccgcgccg agggcggcac ggcgcgggcc
    12901 gccgacctcg tcgaggacgc cctgggctga ccgcacccgg accgggcgga cgccgtgccc
    12961 acccgggctc cggcgtccgc cccaaggccc ccgtgcgatc gtgccgttgc tagattcgtg
    13021 cgccatgcga tcacgtgagt acgacctcca gttccgcgac cgggccgcgc gcatacgcac
    13081 ctggggcctg atcctgctgt ccctggccgc gctgctgtgg atctggtgtg ccgtgctgct
    13141 ggtgatgccc tacgaggccg acacgtccgg caggaccgac taccggagcc ccgcccactg
    13201 cgaggcccgc ctgttcacgg atcgggggac ggccaaccac ggtctgcagg aggggaatta
    13261 ctgcgcgaac gagcgggact ggccggaggc gctcgcggtc ctcggcgcgt cggtcccgtt
    13321 gtcgaccgtc ggggtggggc tcttcaccgt cggcaccgtc acccgccgga tgagcgccca
    13381 cggcgaggcg atgcgcgagc tggacaggct cgcggagggc agggacggct gagcgccccg
    13441 agatcccggg acagcacgcg ccgtttcgcg tacgcaccaa ccgcgacgct ccatgttccc
    13501 ggcgcccacc gcccgggcgc ggcccgccgt cacaccccgc cgaactccca caccagcacc
    13561 tcggcgtccc gcaccgccac cagctccagc ccccggggcc gggtgatccg cgccgagtcg
    13621 cccgccgcca gttcctcgcc gccgagccgc accccgcccc gcaccacgtg cgcgtacacc
    13681 cccgccgcgt ccggcacggc cgtgcgctcc cccgccgcct gccgccggac gtggagcgtc
    13741 gcgccggcct ccgcgaggac gtacggagtg gcgtcggcca ctcctgcgac atgcgtgtac
    13801 gaggggtccc cgaccggctc caggggtgcg agccagaact gaaggaacgt cagcgggctt
    13861 gtgccgtcgt tgcgttcgac atggcgcacg cccccggcgg cgctcaggtg ctggagctcc
    13921 ccggcccgta cgacggtggc gtggccggcc gtgtcgcggt gggtgagctc accctccacg
    13981 acccaggtga cgatctcggt gtggctgtgc gggtgctcgt cgaagcccgc gcccggggcg
    14041 aggcgttcct cgttgcaggc gaggaccgga ccgaacctca ggttgtccgg gtcgtagaag
    14101 cgcccgaagg agaacgcgtg cagtgtctcg atgcccgcgg agccacccgt ggccgggtct
    14161 cctccgcgaa agcggtcgcc ggagcggcgt acgtccgtca cgacccccac ggtagtcctg
    14221 tcgggtatcc cggagccccg cccctccggg cagtcgccct gataaggcag tcttgtgtgt
    14281 gtgccccgac ccgatcctga gcagcccgct gcgaacgacg cccaccgcca cgccgcgacc
    14341 ctgaagcggc tggagcagtc ctccggccgg ctggccgcca acgccatcgc ccgcatggac
    14401 gagacgctgc cgtggtaccg ggcgatgcca ccggagaacc ggtcctggat cggcctggtc
    14461 gcccaggccg gtatcgccgc gttcaccgag tggttccggc acccggagac cccgcaggcc
    14521 atctccaccg acgtcttcgg cacggctccg cgcgagctga cccgggcgat caccctccgc
    14581 cagaccgtcg agatggtgcg gacgacgatc gaggtcatgg agaccgcgat cgaggaggtc
    14641 gcggcgcccg gcgacgagtc cgtgctgcgc gaggcgttgc tcgtgtacgc ccgggagatc
    14701 gccttcgcga ccgcccaggt ctacgcacag gccgccgagg cccggggcgc ctgggacgcg
    14761 cggctggagt cgctcgtggt gaacgccgtg ctctccggcg aggcggacga gggcgccgtg
    14821 tcgcgggcgg cggcgctcgg ctggaactcc cccgaacacg tgtgcgtggt cctgggcacc
    14881 gccccggacg gggacagcga gctgaccgtg gaggcgatcc ggcgggcggc ccggcacgcc
    14941 aagctccagg tgctgaccgg ggtgctcggc caccgcctgg tggtgatcgc ggggggcagc
    15001 gacaaccccc tgaacgtcgc gaagtcgctg atcggcccgt acgcggcggg ccccgtcgtc
    15061 gccggcccgg tggtgcccga cctgctcgcg gccacccggt ccgcgcaggc cgcggccgcc
    15121 ggactcaagg cctgctcggc gtggcaggac gccccgcggc ccgtcctgtc ggacgatctc
    15181 cttccggagc gcgcgatggc gggtgatccc gccgcacgcg accagttggt ggaggagatc
    15241 tacagaccgc tcgaagaagc cggttcggct ctgctggaga cactgagtgt gtatctggag
    15301 caggcgagca gcctggaggg tgcggcccgg atgctgttcg tacaccccaa taccgtgcgc
    15361 taccggctgc gacgtgtgac cgacgtcacc ggctggtcac cctccgacgt ccgttcggcc
    15421 ttcacgctgc ggatcgccct catcctgggg cgcttggccg ctgcggacac cccgtcctag
    15481 acttttgtcg gacttcaaca attcccctga cggttcttcg tccctgtccc cacgggcgta
    15541 ggaggccgtc cccaagagag agtgtgagtg tgctcgtact cgtcgctccc ggccaaggcg
    15601 ctcagacgcc cggcttcctg actccctggc tcgaactccc cggcgccgcc gaccgcctcg
    15661 cgggctggtc ggacgccatc gggctcgacc tcgcccacta cggcacgaag gccgacgcgg
    15721 acgagatccg cgacacggcg gtggcccagc cgctgctggt cgccgcgggc ctcctgtccg
    15781 ccgccgcact ggacgccgcg cccgacgtgc tcgcgggcca cagcgtcggc gagatcaccg
    15841 ccgcggcgct ggccggcgtc atcgacgacg aggccgccct gcgtctcgta cgcacccgcg
    15901 gcctcggtat ggccgaggcc gccgcggtca ccgagacggg catggccgcg ctcctcggcg
    15961 gggaccccgc cgtgaccgtc ccgcacctgg agaagctcgg gctcaccccg gcgaacgtca
    16021 acggcggcgg ccagatcgtc gccgccggca ccgccgagca gatcgccgcg ctggccgagg
    16081 acaagcccga gggcgtgcgc cgcgtggtgc cgctcaaggt ggccggcgcg ttccacacgc
    16141 accacatggc tccggccgtg gagaagctgc gcgccgccgc cggcacgctg acggtcgccg
    16201 acccgaaggc cacgtacgtc tcgaacgccg acgggaagac ggtcgccacc ggcaccgagg
    16261 tcatcgcccg gctcgtcggc caggtcgcca acccggtccg ctgggacctg tgcatggaga
    16321 ccttcgagga gctcggtgtc acggccctca tcgaggcggc acccggtggc accctggtcg
    16381 ggctcgccaa gcgcgcgctg cccggcgtga agaccctcgc gctcaagaca cccgatgacc
    16441 tcgacgcggc ccgcgcgctc atctccgagc acgcaggcgc ctaaggagcc cgagagcatg
    16501 tcgaagatca agcccagcca gggcgccccg tacgcacgga tcatgggtgt cggcggctac
    16561 cgccccaccc gggtcgtgcc gaacgaggtg atcctcgaga cgatcgactc gtccgacgag
    16621 tggatccgct cccgctccgg tatcgccacc cgccactggg cctccgagga ggagaccgtg
    16681 gccgcgatgt ccgtcgaggc cgcgggcaag gccatcgccg acgccgggat cgcccccgag
    16741 cagatcggcg cggtcgtcgt ctccacggtc tcgcacttca agcagacccc cgccgtcgcg
    16801 acggagatcg gccacaaggt cggcgcgggc aagcccgccg ccttcgacat ctcggccggc
    16861 tgcgcgggct tcggctacgg cctgaccctc gccaagggca tgatcgtgga aggctccgcg
    16921 gagtacgtcc tcgtcatcgg cgtggagcgg ctcagcgacc tgaccgacct ggaggaccgc
    16981 gcgacggcct tcctgttcgg tgacggcgcg ggcgcggtcg tcgtgggccc ctcgaagcag
    17041 ccggccatag gtccgacggt ctggggctcg gagggcgaca agtccgagac gatcaagcag
    17101 accgtggcgt gggacgtctt ccacgccgac cggccggaga agttccccgc catcacgcag
    17161 gagggccagg cggtcttccg ctgggccgtc ttcgagatgg cgaaggtcgc ccagcaggcg
    17221 ctggacgccg ccgggatcgc cccggaggac ctggacgtct tcatcccgca ccaggccaac
    17281 atgcggatca tcgactcgat ggtgaagacc ctcaagctgc cggagcacgt cacggtcgcc
    17341 cgtgacgtgg agaccaccgg caacacctcg gccgcctcga tcccgctcgc gatggagcgg
    17401 cttctggcga ccggtcaggc caagagcggc gacaccgcgc tcatcatcgg cttcggggcg
    17461 ggtctcgtct acgccgcgac ggtcgttacc ctcccctagg cacaccggat cttttcggtc
    17521 cgtacgcccg aaccctgcag aaacacatcg aaggagcccc aacatggccg ccactcagga
    17581 agagatcgtc accggtctcg ccgagatcgt caacgagatc gccggtatcc cggtcgagga
    17641 cgtccagctg gacaagtcct tcaccgacga cctggacgtc gactcgctgt ccatggtcga
    17701 ggtcgtcgtc gccgccgagg agcgcttcga cgtcaagatc cccgacgagg acgtcaagaa
    17761 cctcaagacg gtcggggacg ccgccgacta catcctgaag caccagggct gaaccgagcc
    17821 ctgatccgtg tgtcgccacc cggcggtggc gccgctgatt cacgaccctc tacacgtgga
    17881 gaagattttc cagtgagccc gaccaatcgc accgtggtcg tcaccggtat cggcgcaacc
    17941 actccgctgg gtggcgactc cgcatcgacc tgggaaggtc tgatggccgg tcgttccggc
    18001 atcaagcctc tcgagggcga acgtttcgcc gaactgcccg tccggatcgc cgccctcgcg
    18061 gcagtcgacc cgggcgatgt actgccccgc cccctcgccc gcaagctgga ccgctcggcg
    18121 cagttcgcgc tgatcgcggc tcgcgaggcg tgggcggacg ccggttacac cggcaaggcc
    18181 ggtgaggacg agaagatccg gcccgagcgt ctgggttcgg tcatcgcctc cggtatcggc
    18241 ggtgtgatca ccctgctcga ccagtacgac gtgctgaagg acaagggcgt acgccgtgtc
    18301 tccccgcaca ccgttcccat gctcatgccc aacggcccgg cggccaacgt cggcctggag
    18361 gtcaacgccc aggccggtgt ccacaccccg gtctcggcgt gcgcgtcggg tgccgaggcc
    18421 atcgggtacg ccgtcgagat gatccgtacc ggccgtgccg acgtggtcct cgccggtggc
    18481 accgaggcgg ccatccaccc gctgccgatc gccgcgttcg ccaacatgat ggcgatgtcc
    18541 aagagcaacg acgagcccga gaaggcctcc cgcccgtacg acaccgcccg tgacggcttc
    18601 gtgctcggtg agggtgccgg tgtcgtcgtc ctggagtccg ccgagcacgc cgccgcccgt
    18661 ggcgccaggg tctactgcga ggtgctgggc cagggcctgt ccgctgactc gcaccacatc
    18721 gcgcagcccg agcccaccgg gcgcggcatc gccgccgcca tgcagaacct gctcgactcc
    18781 acggacctca agccgtccga ggtcgtgcac ctgaacgcgc acgccacctc cacgccgcag
    18841 ggcgacgtgg cggaggtcaa ggcgctgcgc caggtcctgg gcgaggacct ggaccacgtc
    18901 gccatctcgg ccacgaagtc gatgaccggc cacctgctgg gcggcgcggg cggcatcgag
    18961 accgtggcga cggtgctggc cctgcaccac cgcatggcgc ccccgaccat caacgtcgac
    19021 gaactcgacg aggcggtgga cgcggacatc gtgcgcgaca aaccccggcc tctgccggag
    19081 gggtcgatcg cggcgatcaa caactcgttc ggtttcggcg gccacaacgt ggtgctggcc
    19141 ttccggtcgg cctgacgccg cgtcaccgca cgacggacca tggcccgctt cccgtccggg
    19201 aagcgggcct tgtgccgtcc gggggcccgg gtctcacacc acctggtgga gccagcgcac
    19261 cggcgcgccc tcgcccgcgt gccggaagga ctccagttcg tcgtcccacg gcttgccgag
    19321 gagccgggcg acctccgccc ccaggtccgc ctccccgccg gcggaccggg cgagcgctgc
    19381 ccgcagccgg tcctccggga ccaggatgtc gccgtgcatt ccggtgacgg cgtggaagat
    19441 gccgaggccg ggcgtggcgc tgtagcgctc gccctccgcc gtggggcagg gctcggcggt
    19501 cacctcgaag cgcagcatgt cccagccgcg cagggccgag gcgagctccg ccgccgtacc
    19561 gacccggccc tgccaggaga attcggaccg ccaggtgccc ggagcggcgg gctgtctgat
    19621 ccagtcgagc tgcacccgca caccgaggac acccgccacc gcccattcga cgtgcgggca
    19681 gagcgcgcgc ggtgcggagt gaacgtacag aactccacgt gtcgtcaccg ggacctccag
    19741 tgtgggacga ggttcgcctt ccccagcggc ctcgcgcccg taccgtctct ttccggacga
    19801 ctcccgaggt tgtcatcagt aaacagcatc gggagtgaat ctcctgaaaa aggacaatat
    19861 atgacatgaa gtaacttacc ggggctccgc ctgttcggac acggccggaa agacgtcact
    19921 ggttcgacgg gggaaaagct accgtgcccc ggcgccgggt gtgtgacgta ccgtcggtcc
    19981 ggggcccatg attcgtccgg cattcacccg ccagggcgcg cacccccgcc acctggggct
    20041 gtccgactgt gccaggggcg atcgcccgca cgaccggagg gaaatcggga tggccgaggg
    20101 ccagtcacgc caccgcgtcc gccgcgccgc ggccgcgctg acggcggtgg cgacggtcgg
    20161 tgtcgccgtg ttgaccggct gtggtggcgc aggggacggc gggagcacgg cgcggccctc
    20221 gcggagcccg tcgccgacgc ccgcgtggaa cgcgagcccg gcctccgtcg ccgccgtcgg
    20281 ggactccatc acccggggct tcgacgcctg ctcggtgctg gccgactgcc ccgaggtgtc
    20341 atgggcgacc ggcaccgacg acgcggtgcg cagcctcgcg ctgcgactcc tgggcccctc
    20401 gaaggccgcc tcgcacagct ggaaccacgc ggtgtcgggc gcgcggatgg cgcagctgcc
    20461 cgagcagatg gcgctggccg cgaaggagcg gccggagctg gtgacggtga tgatcggcgc
    20521 caacgacgcc tgccgggact cggtggagct gatgacgccg gtggcggact tccgggcctc
    20581 cttcgaggcg tcgctgcggc agttgcgcgc cgaggcgccc cgggcgcagg tgtacgtgtc
    20641 gagcgtgccg gatctgaagc ggctctggtc gacggggcgg gagaacgccc tgggcaagca
    20701 gatctggaag ctgggcatct gccggtcgat gctgggcgac gcggacgaca tgggggcggc
    20761 ggccgtggcg cggcgggacg ccgtgcagga gcgggtggtc gccttcaacg gcgtcctgcg
    20821 ggacgtctgc gcgaaggacc ggcactgccg gtacgacggc ggggcggtct tcgactaccg
    20881 gttcaccggc gcgcagctca gccgctggga ctggttccac cccggacgcg acggccaggc
    20941 caggctggcg gagatcgcct accgcaacgt cacggccgcc ggaccgcccg cgtaaagtcc
    21001 gtgatcatga cgacgggcac cgtgatacgc agcgaggact tcacccccag ggc
//
