LOCUS       NZ_GG667191            26574 bp    DNA     linear   CON 01-MAY-2024
DEFINITION  Corynebacterium lipophiloflavum DSM 44291 SCAFFOLD1, whole genome
            shotgun sequence.
ACCESSION   NZ_GG667191
VERSION     NZ_GG667191.1
KEYWORDS    WGS; RefSeq.
SOURCE      Corynebacterium lipophiloflavum DSM 44291
  ORGANISM  Corynebacterium lipophiloflavum DSM 44291
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Corynebacteriaceae; Corynebacterium.
REFERENCE   1  (bases 1 to 639586)
  AUTHORS   Qin,X., Bachman,B., Battles,P., Bell,A., Bess,C., Bickham,C.,
            Chaboub,L., Chen,D., Coyle,M., Deiros,D.R., Dinh,H., Forbes,L.,
            Fowler,G., Francisco,L., Fu,Q., Gubbala,S., Hale,W., Han,Y.,
            Hemphill,L., Highlander,S.K., Hirani,K., Hogues,M., Jackson,L.,
            Jakkamsetti,A., Javaid,M., Jiang,H., Korchina,V., Kovar,C., Lara,F.,
            Lee,S., Mata,R., Mathew,T., Moen,C., Morales,K., Munidasa,M.,
            Nazareth,L., Ngo,R., Nguyen,L., Okwuonu,G., Ongeri,F., Patil,S.,
            Petrosino,J., Pham,C., Pham,P., Pu,L.-L., Puazo,M., Raj,R., Reid,J.,
            Rouhana,J., Saada,N., Shang,Y., Simmons,D., Thornton,R., Warren,J.,
            Weissenberger,G., Zhang,J., Zhang,L., Zhou,C., Zhu,D., Muzny,D.,
            Worley,K. and Gibbs,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JAN-2009) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
REFERENCE   2  (bases 1 to 639586)
  AUTHORS   Qin,X., Bachman,B., Battles,P., Bell,A., Bess,C., Bickham,C.,
            Chaboub,L., Chen,D., Coyle,M., Deiros,D.R., Dinh,H., Forbes,L.,
            Fowler,G., Francisco,L., Fu,Q., Gubbala,S., Hale,W., Han,Y.,
            Hemphill,L., Highlander,S.K., Hirani,K., Hogues,M., Jackson,L.,
            Jakkamsetti,A., Javaid,M., Jiang,H., Korchina,V., Kovar,C., Lara,F.,
            Lee,S., Mata,R., Mathew,T., Moen,C., Morales,K., Munidasa,M.,
            Nazareth,L., Ngo,R., Nguyen,L., Okwuonu,G., Ongeri,F., Patil,S.,
            Petrosino,J., Pham,C., Pham,P., Pu,L.-L., Puazo,M., Raj,R., Reid,J.,
            Rouhana,J., Saada,N., Shang,Y., Simmons,D., Thornton,R., Warren,J.,
            Weissenberger,G., Zhang,J., Zhang,L., Zhou,C., Zhu,D., Muzny,D.,
            Worley,K. and Gibbs,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JAN-2009) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000159635.1-RS_2024_05_01
            Annotation Date                   :: 05/01/2024 01:00:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,353
            CDSs (total)                      :: 2,297
            Genes (coding)                    :: 2,213
            CDSs (with protein)               :: 2,213
            Genes (RNA)                       :: 56
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 84
            CDSs (without protein)            :: 84
            Pseudo Genes (ambiguous residues) :: 0 of 84
            Pseudo Genes (frameshifted)       :: 21 of 84
            Pseudo Genes (incomplete)         :: 64 of 84
            Pseudo Genes (internal stop)      :: 11 of 84
            Pseudo Genes (multiple problems)  :: 11 of 84
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:27:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 83557
            Orig. end                         :: 110131
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GG667191.1.
            This sequence is generated as a part of the Human Microbiome
            Project (HMP), funded by the National Institutes of Health (NIH),
            National Human Genome Research Institute (NHGRI) Large-Scale
            Sequencing Research Network and the National Institute of Allergy
            and Infectious Diseases (NIAID) Microbial Genome Sequencing Centers
            Program.  The mission of the HMP is to generate resources to enable
            the characterization of the human microbiota, the microbial
            communities living within human bodies, and analyze the role of
            these organisms in human health and disease.  See
            http://www.hmpdacc.org/ for more information.
            The sequenced strain was obtained from DSMZ.  The genomic DNA was
            prepared from a single bacterial isolate.  The sequence generated
            included at least 10 fold coverage of Roche/454 Lifesciences FLX
            fragment data and at least 8 fold clone coverage of Roche/454
            Lifesciences paired-end data.
            The Roche/454 Lifesciences sequence was assembled using the
            Roche/454 Lifescience Newbler assembler.  The contigs from the
            Newbler assembly were aligned with mapping tools such as Mosaic and
            Crossmatch and these data were used for error correction for this
            version of the draft assembly.  This draft assembly meets the HMP
            draft quality standards (more than 90% of the genome is included in
            contigs, more than 90% of a core set of bacterial genes are found
            with > 30% identity and > 30% length; more than 90% of the bases in
            the assembly have more than 5 fold sequence coverage, the contig
            N50 length is greater than 5kb, the scaffold N50 length is greater
            than 20kb, and there is less than 1 gap per 5kb).
            This is a reference genome for the Human Microbiome Project.
            This project is co-owned with the Human Microbiome Project DACC.
            Genome Coverage: 32x
            Sequencing Technology: 454; ABI
            Annotation was added to the contigs in April 2009.
            Product names were updated in June 2013.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26574
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26574
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26574
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16574](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16574)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gap             1051..2780
                     /estimated_length=1730
     gene            <2991..3854
                     /locus_tag="HMPREF0298_RS00405"
                     /old_locus_tag="HMPREF0298_1793"
                     /pseudo=""
     CDS             <2991..3854
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558200.1"
                     /locus_tag="HMPREF0298_RS00405"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1793"
                     /product="IS3-like element IS3502 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="DDHRTDYSVKRMCTVLGLNRSSYYKWKASSAQRHRRLVDDAILGA
                     KVKAIFDDKKQLYGAKRIAAELTFNDAYSSTGPVNHKRIARIMRKLQLRGYTKKRKVTT
                     TQRERHRFIFADLVKRNFTAPAANRILVGDITYLPIADGSNMYLASVIDCYSRMLVGFA
                     IADHMRTDLVEEALEHARRTRGSLSGAIFHSDHGSVYTSSQFQAVCRRLNVTQSMGAVG
                     SSADNSLAESFNAALKREVLKDQKVFSNQLVCRRDVFAWCARYNTTRRHSWCKYLTPIE
                     YESQAS"
     gap             4028..6446
                     /estimated_length=2419
     misc_feature    complement(6751..6764)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: strong, score: 21.85"
                     /tool="antismash"
     gene            6821..6976
                     /locus_tag="HMPREF0298_RS11685"
                     /old_locus_tag="HMPREF0298_1795"
     CDS             6821..6976
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gallidermin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="HMPREF0298_RS11685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1795"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_006839087.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.4e-17, bitscore:
                     58.8, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="Gallidermin (E-value: 3.8e-06, bitscore:
                     22.5, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.3e-06, bitscore:
                     22.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDFTLDFAEGDAADTVSPQITSKSLCTPGCITGWMMCNTVTKGC
                     SFTIGK"
     CDS_motif       6821..6880
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSDFTLDFAEGDAADTVSPQ"
                     /locus_tag="HMPREF0298_RS11685_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6881..6976
                     /prepeptide="core"
                     /locus_tag="HMPREF0298_RS11685_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="4.80"
                     /molecular_weight="3107.7"
                     /monoisotopic_mass="3105.5"
                     /core_sequence="ITSKSLCTPGCITGWMMCNTVTKGCSFTIGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDFTLDFAEGDAADTVSPQ"
                     /leader_location="[6820:6880](+)"
                     /alternative_weights="3125.8"
                     /alternative_weights="3143.8"
                     /alternative_weights="3161.8"
                     /alternative_weights="3179.8"
                     /alternative_weights="3197.8"
     gene            7192..7584
                     /locus_tag="HMPREF0298_RS12050"
     CDS             7192..7584
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF0298_RS12050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157464330.1"
                     /transl_table=11
                     /translation="MPLFETQARNRIEAPSKPKAVPVALAVAAAIALVAAFFSIMSGVA
                     GAVLVIASFICLVVYFGHRPSRKYLSISLVLSVLCVVVAAVGLLMQLSDVQAHCSWIFP
                     QGSPAHVACFQENYSPWRGAAQALFR"
     gene            complement(7678..8466)
                     /locus_tag="HMPREF0298_RS00415"
                     /old_locus_tag="HMPREF0298_1796"
     CDS             complement(7678..8466)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /locus_tag="HMPREF0298_RS00415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1796"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_006839088.1"
                     /transl_table=11
                     /translation="MKKRISLALLAAASLAVPSVSLADEAVPAPGVSPSISSSPFALSS
                     SQITAPTDSPSEPPSTEETPDHSFSLAAIAIVDGQEISSCTGITLNPNWILSAAHCFDE
                     DLTNDAYTVFTSARSGVEEVHQIPGADLAVARLAGDRPDVGCTPLPDSSPQVGTTAEVY
                     VFRDYGGVAALPFTIQANDHLAGNPAAGAGVHPMLSLVPQADGSLTRGGDSGAGVFVAD
                     VDGRKTVVGIVAGLSQTSNVTLAEDLARYSNDIEQIVGIC"
     misc_feature    complement(8460..8474)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 23.7"
                     /tool="antismash"
     gene            complement(8494..9327)
                     /locus_tag="HMPREF0298_RS00420"
                     /old_locus_tag="HMPREF0298_1797"
     CDS             complement(8494..9327)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="HMPREF0298_RS00420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1797"
                     /product="ABC transporter permease"
                     /protein_id="WP_006839089.1"
                     /transl_table=11
                     /translation="MRTFDRIKSFSLVFYAEVGRTFQERITYRTQLVLGLLTGVVGLAQ
                     FAILGYYISLGGTPPGLEQYGGNIIAFMIVGSLFSALAVMMMNSLKMQIQSEQKRGTLE
                     AIALSRAGLFKFLIAGGVFGLVMTLISSVAIFTIFGHLFDFELKLNPIGLVVSVAFTVV
                     CMWAIGLCAAAYILVSKQGEPVTWVVTTLLTLFSGVMYPISVFPDVVASAASYLPTAGM
                     LHSIRLSLFSGAPTFEVLKALMPTIVTTALLIPLGVVMWRKGVHKVRVNGTLGTY"
     gene            complement(9324..9923)
                     /locus_tag="HMPREF0298_RS00425"
                     /old_locus_tag="HMPREF0298_1798"
     CDS             complement(9324..9923)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="HMPREF0298_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1798"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_169304944.1"
                     /transl_table=11
                     /translation="MSVKYGTTTILSGFNEQIRGPGLCSITGANGVGKTTLLRLACGIS
                     LPTSGSVLIDGESTEKHWSSIRERLGVSLYSERSYHFRLTGLQNLIYFGRLAGLRKKET
                     LNRLAPLRQEFTVDPLLERHFSDLSLGQRKIFGMLIALVIGDDLIILDEPTATLDTTNS
                     LAALTMMQWVIARGVTVLISTHDQNLIAQSDQVVAL"
     gene            complement(10001..11197)
                     /locus_tag="HMPREF0298_RS00430"
                     /old_locus_tag="HMPREF0298_1799"
     CDS             complement(10001..11197)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="HMPREF0298_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1799"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_169304945.1"
                     /sec_met_domain="LANC_like (E-value: 2.9e-30, bitscore:
                     100.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTRTPIALEHLDAHLFEGLSSDHRTERISHSPFSMIDGALGDA
                     YTASALYHATEDQKWWDLLMNRVSTLVEVLRTHRFDQGGLLGGLSGMAYLLTVSRHNEE
                     EFSNALSSLNSRISTLAERKLWDLHRSIGKRREDYDYAVGLAGIAHYLFVADEQYRGLA
                     KQICNEFAELSLQPLPHSFWTGAADLDPAMVEHTPELGNGMRDLGFAHGIAGVIAVLKV
                     GHKVFEDPSYLTAATRLMDVLVADIAEHNHSGPSYFQTPSPASNPPRPSTKSRQAWCYG
                     TPSAEISAAGCQPLEQQLNSSLVHGEDYFDPQLGSFNDSGLCHGVAGRQYLADQLGFAA
                     SASWLEHVENQITHFLSGPSTGVDLSFWHGIGGTTAVWAGRESSHGYAPALTILGVKK"
     CDS             complement(11157..>12616)
                     /codon_start=2
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.4"
                     /locus_tag="HMPREF0298_RS00435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1800"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_006839092.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-12, bitscore:
                     39.6, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSPQQAFNSVREFHTSYPRTLNVNSVESHPWELTLDSLQVWSDGT
                     QVHLCDEDGSPLRFRPTSMVGVGAYPEWLMQIAMAATGSTPNINWSWGTISDHVDYLPG
                     VRHGRVIVSRPAFRYRGLEDVNAFNEWADSHGISEWVRMGDSDRKILLKRTAPGFSEAV
                     RSQLRRSDGWVYESFDSELTPLVRDHQDRPIFSEICLTFGISSPAPDPDALRTTAQSLS
                     VVATNQDKELIPGISDTANLTIVPRDGFRERVIRRLFSTEETAAGAYFIRYPTDSGESG
                     LRLRYPRRTSTGAAVETAIREMTSSGWLLGLEEKAHSLEFERYGGPAVFPLFAELFSLE
                     SRVVAHLSAASSTDTIDERLHLPILDRWLNLFPDYRSVIVEFAVQSEDSSTVQKAASAL
                     LREADSLGDLASADLIDPSIRAHMKSLANKISAHSVGTYELQSAAHLFCNRVGISTDRE
                     KALWAALSKIERRNHHANDTHPHRSRAS"
     gene            complement(11157..>12618)
                     /locus_tag="HMPREF0298_RS00435"
                     /old_locus_tag="HMPREF0298_1800"
     gap             12619..15273
                     /estimated_length=2655
     gene            complement(<15274..16574)
                     /locus_tag="HMPREF0298_RS00440"
                     /old_locus_tag="HMPREF0298_1801"
     CDS             complement(<15274..16574)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="HMPREF0298_RS00440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1801"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_245527432.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-13, bitscore:
                     45.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-10,
                     bitscore: 37.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRAASTDITVLEDLAEATTVTDLLRLAGRHPLLWAELNTFHPEI
                     VTNASQIVDGSEQRPKIIRKTARALSGLIARSAGRATPSRMISTVGEISSSPSNVPGEI
                     TLEPTLTITASRSSIVADDKKAEGTILRWNPSAVIMDERCYITAPRSQSTPVFSSVGVN
                     PLIKGIRAWAKTPISGQDLRATILNAYPDADMASIEKVIHQLVKHEFLLSEKSIGYDTY
                     RSQRNLFTQEFALEADENHLPAQTEYADEDVDSYRSAVGAPPTGMREELTAFLEHGFTH
                     GAFEYNDSGLAQVLAQLLLEKYGASRIPLTHLIHPVFGLDWKTVTTSPQARSLTATKSS
                     SDYLRSVYTRGIKSADGWVDLQSEAASLPREKRTYSRFDSLDLIASLHGTPTDPTYNIA
                     DAISSIPGGVASARFDLLPSRHLNDEYAINIDWVS"
     aSDomain        complement(15933..16175)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HMPREF0298_RS00440_Lanthipeptide_LanB
                     _RRE.1"
                     /evalue="5.40E-12"
                     /identifier="RREFam001.1"
                     /label="HMPREF0298_RS00440"
                     /locus_tag="HMPREF0298_RS00440"
                     /protein_end="214"
                     /protein_start="133"
                     /score="37.2"
                     /tool="antismash"
                     /translation="NPSAVIMDERCYITAPRSQSTPVFSSVGVNPLIKGIRAWAKTPIS
                     GQDLRATILNAYPDADMASIEKVIHQLVKHEFLLSE"
     gene            complement(16552..17112)
                     /locus_tag="HMPREF0298_RS12360"
                     /old_locus_tag="HMPREF0298_1802"
     CDS             complement(16552..17112)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF0298_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF0298_1802"
                     /product="hypothetical protein"
                     /protein_id="WP_006839094.1"
                     /transl_table=11
                     /translation="MNAVIDSASQPVAPLRRHFVQITGTLRINGKEVSSTRAAQLLHMV
                     ASGGGRLARSTIEKVLYGGFCSRSSLWYPLKVCQESGVDIHYDKVTRSVVLHDAVLFDY
                     DVAVNYLRQGNPQAALWVLNGWPFASSTDPYAESLTTRLRDEFLAAQPNMYRSEIEDAF
                     EVLDTKCLGHSAHRMPHYSSCIH"
     misc_feature    17080..17094
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    complement(17105..17116)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     gene            complement(17146..18501)
                     /locus_tag="HMPREF0298_RS12635"
                     /old_locus_tag="HMPREF0298_1803"
     CDS             complement(17146..18501)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF0298_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF0298_1803"
                     /product="hypothetical protein"
                     /protein_id="WP_245527417.1"
                     /transl_table=11
                     /translation="MYITGMAAPILALLAGLAETREKKARYGGTNLRPVSPIKTRAARL
                     MVLIALSAVFHLLNFGVAWLYAVADYRAGAGTILSAGALSWIGSISTIALFSIVARVTG
                     MIPALLVAVVYQVAGTLTAEASWWWAFPPAWPVRLLLPTLGIHSNAVPLETGHPLAEES
                     PVAGLALNLAFAVVTVGLAVALRGQRVTGKRPNPHRRDSDDGDDPKHATVDPSVTGLSH
                     HPVVHIRGEHNVRENQSLLNVLAAVHRPLSRTAATPLAITAVVLVYAVALIYPPGYVSG
                     LYTFAILPLGAGLLPVMTWSALSGAWPIAVTENHRIRGAYLAWQAILLLLLAVGTGGAH
                     LLAGGDLTQTARMVVLWALTGILLTMVSTALRIRFGSGVAIAATVLWTVVSATLGGDVL
                     AETVLWLVAVPSWPETADTAARFVIAIVLQALLISGSTVWATREIRGSERRG"
     gene            complement(18714..19451)
                     /locus_tag="HMPREF0298_RS11690"
                     /old_locus_tag="HMPREF0298_1804"
     CDS             complement(18714..19451)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011069218.1"
                     /locus_tag="HMPREF0298_RS11690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1804"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_083789470.1"
                     /transl_table=11
                     /translation="MGFVTSTALNTVALSCDNLRIGFGGHQVLDGFSMQVKTGRVHALL
                     GRNGAGKSTCFRIILGLEDRGTGTVEILGAQRTRDSLINIGASINGPALYPHLSARDNA
                     RVHAQLLGLGTDEADRTLSMVGLQETGRKKARDFSTGMKARLALAIAMLGSPPILLLDE
                     PQNGLDPQGIVDLRGFLRSWTTGGGTVLVSSHQLGEVARLTDDITVLVNGRDAYSGPLH
                     DFADPDRLEDEFLRMTHSTGATR"
     gene            complement(19536..20258)
                     /locus_tag="HMPREF0298_RS00460"
                     /old_locus_tag="HMPREF0298_1805"
     CDS             complement(19536..20258)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018120564.1"
                     /locus_tag="HMPREF0298_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1805"
                     /product="response regulator transcription factor"
                     /protein_id="WP_006839097.1"
                     /transl_table=11
                     /translation="MEHAHGSQGSETRNDRPIRVLVADDQPMMITALKTILNTQDDIEV
                     VTTAGNGREAIEAAERWRIDVAVLDIRMPHLNGIEAAQIIRQRRETTKVLMLTTFDSED
                     LVRRALEIGVQGFMLKDSGPEALIDAIRRIHQGASVLSPGITEFVINGFRDSCVAESTT
                     TAPPVEPLTPRELEVLERVALAETNAEIAAHLHIGAATVKTYVSRLIAKLGVRDRVGLA
                     VWAHTSGIVSAQSSQAVK"
     CDS             complement(20304..>21651)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=3
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="HMPREF0298_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1806"
                     /product="histidine kinase"
                     /protein_id="WP_245527418.1"
                     /transl_table=11
                     /translation="STSKPSPCIVLLKSDSWSVTRYTESDLLNAHVLMSWDMSASLRGI
                     PSHIEDWGFAVLATFLAFIYGAIATNGSQQEIVQAILAILFIPALLFWRTRPTASSVAM
                     LLLMALWTANWFSALPLNLGFTPFVLVMPIIVYTTARFLERRIISFLFYAAALVYCFVS
                     PIMWYQTESGMLYHSSDQGLSWLLIQWLGLTAIRQIAINRRREEDRHAEQQRNREHAAL
                     EEQSAIRERERVQIAREIHDVLAHSLTLINVQASAGIMVARQRPSKDHAGHEEILESIQ
                     DTSSSALAEVRGIVKALRSETDSISLDEITNLASAVEQIDKYRKTGMEITASLPSDRDL
                     AEISSSSPLIVQLGVRRILNESLTNVVRHQGVGSRVEVDISVDWEDDEITLDIESWSPG
                     VQDEVSPALTGTKSGLIGMQERVDSLNGQIQYHSRQGYFRVQASLPISPC"
     gene            complement(20304..>21655)
                     /locus_tag="HMPREF0298_RS00465"
                     /old_locus_tag="HMPREF0298_1806"
     gap             21656..22274
                     /estimated_length=619
     gene            complement(22502..22891)
                     /locus_tag="HMPREF0298_RS00470"
                     /old_locus_tag="HMPREF0298_1807"
     CDS             complement(22502..22891)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019175580.1"
                     /locus_tag="HMPREF0298_RS00470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1807"
                     /product="heavy metal-responsive transcriptional regulator"
                     /protein_id="WP_006839099.1"
                     /transl_table=11
                     /translation="MRIGQLAEATGTTTKTLRFYEESGLLPPAERLASGYRDYAENAVG
                     RVGFIHRGQAAGLTLAQIRQILDIRDGGQAPCEHVRDLLDVRLAEIEQQIAQLSVLRDT
                     IADLRQDAAHPDPETCSTDQVCRYL"
     gene            23000..24424
                     /gene="merA"
                     /locus_tag="HMPREF0298_RS00475"
                     /old_locus_tag="HMPREF0298_1808"
     CDS             23000..24424
                     /EC_number="1.16.1.1"
                     /GO_function="GO:0016152 - mercury (II) reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="merA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005326047.1"
                     /locus_tag="HMPREF0298_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF0298_1808"
                     /product="mercury(II) reductase"
                     /protein_id="WP_006839100.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-55, bitscore:
                     183.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEKFDLAIIGSGGGAFAAAIRATGLGKRVVMVERGTVGGTCVN
                     TGCVPSKALLAAAEARHVALDSARFPGVAASAGPVDMPALIQGKAALVESMRTEKYVDL
                     AADYGWTMISGDASFTGTQDAPLLRVISPDGAVRTIEAGHYLVATGSAPYVPPVPGLAE
                     AGYLTSTTAMELDEVPESMLILGGGYVALEMAQLFSRLGSRVTMLVRSRLASQEEPEAS
                     KALAGMFADEGIRVVRRAMADSVASGPDGVSVTANVAGGEEVFRASHILVALGRRPVTE
                     GLDLDAVGVKTGASGEIVVDSRLATSNPRVWAAGDATGHREFVYVAAAHGALAVDNAFT
                     DALAEVDYRHLPRVAFTSPAIGAVGMTEKEAVAAGISCECRVLPLEYVPRAVVNRDTRG
                     FIKVVADRDTGRILGLSAVAKDAGEIAAAGVYILEAGMTTAQVAAAWSPYLTMAEGIRI
                     AAKAFTTDVSKLSCCA"
     gene            <24767..>24917
                     /locus_tag="HMPREF0298_RS12640"
                     /pseudo=""
     CDS             24767..>24917
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612336.1"
                     /locus_tag="HMPREF0298_RS12640"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS481 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGKLIHIDVKKLSRIPDSGGWRVHDRSATGRPDRVRPRPCRCR"
     misc_feature    25460..25473
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    complement(25767..25781)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 20.22"
                     /tool="antismash"
ORIGIN
        1 tcgtcgaaga tctgcacgtc gacacttttg ccggcgaagc tccacggcac agagtagaaa
       61 tgcttctcca cttggacgtg gtagttcacc ccggccttgg ctttacgcca cgtggaatac
      121 gaccagcgct gttgaggcag cgggcgcaat gcttctgctt cgctttcaac aaacaactgc
      181 ctgcggcttg cgttgcggcc ccggaatcct tcccggtcgt tgatccagtc gacctgtgct
      241 gcaatagcgg cgttgagagc gtcgaacgtg gagaactctt ggcccgataa cgcttctgcg
      301 acccaggtct ggacgatatc gaccgccttt tccacatggg ccttatccct gggtttaccc
      361 ggcctagccg gggtaatccc gcaaccgtag aactcggcga actgctggta gcgctcgttg
      421 acttcacgca ccgtcgcacc acgtgtgatc tggttggttg ctgtcgaggc gttatcgggc
      481 acgatgcgca ccggcacgcc accgatatag tccaacgcgt cgcggtgggc acacagccac
      541 gaccgcatcc gcatatccgg ccacgcactg gcatggataa gccccgaatg cggcagcgac
      601 gccacaaaca catacgcctg cacagacacc ccggtcaacg ggtcaacaac tgccatggtt
      661 tccccggacc aatcaacgca cagctcctca ccaggggcat gggtcaaaag cgcagtcagg
      721 tcgttgacat cgacgtagtt ttcaaacagc gcgcagaact gccggtagga ataatgctgc
      781 tggccagaag tagcctgacg gcgggtgtat ttatggtgtt ccacctttaa cgtcacccgc
      841 tcaccgcgtc ggcgccgggc ggcgatgcct gcgaaatccg gttccacaaa cgcatctgaa
      901 tcccgccggc gattatccgg aaacaactcc gaaagctcct gcggcgacaa cgcggtaatc
      961 gtgtcctcgt ccatcccagt cgagcgcaac acccgactgg ccttatcaat actgctgcgc
     1021 gagcacccca aatccgacgt gatctgcgac nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2761 nnnnnnnnnn nnnnnnnnnn cagaccacga gcggccttgc acaagcgcca gcatgatcaa
     2821 cctgtaattg gtgaccacac caaactcctt ccatggttac gcggcccgcg cgtacacact
     2881 gcgcagggcc gtcaaccaca gactgccaac ccaactaccc ccggtacccg atacacgcac
     2941 acccagtacc cgatacccgc ccgaccggta ctaaaaaccg aacccggtca gatgaccacc
     3001 gcaccgatta ctcggtcaag cggatgtgca ccgtactcgg gttaaaccgc agctcctact
     3061 acaaatggaa agctagcagc gcccagcggc accgcagact ggttgatgat gccatactcg
     3121 gagccaaggt gaaggccatc ttcgacgaca agaagcagct ctacggcgca aaacgcattg
     3181 ccgccgagct gactttcaac gatgcgtaca gtagcaccgg accggtcaac cataagcgca
     3241 tcgcccggat tatgaggaag cttcagctgc gcggctacac gaaaaaacgt aaggtcacga
     3301 caacacagcg tgagcgtcat cgctttatat tcgctgacct ggtcaagcgg aacttcactg
     3361 cgccagctgc caataggatc ctcgtcggcg atattaccta tctgccgatc gcagacgggt
     3421 cgaatatgta tctggcttct gtgattgact gctactcgcg gatgctcgtc ggcttcgcga
     3481 tcgcagacca catgcgcacc gacctcgtcg aagaagcgct cgagcatgct cgccgtaccc
     3541 gtggcagtct ctccggggcg atcttccact cagatcatgg cagcgtgtat acctcatcgc
     3601 agtttcaggc tgtctgccga agactcaacg tcacccagtc gatgggagca gttggcagca
     3661 gcgctgataa ttcactcgcg gagtcgttta acgcggcgtt gaaacgagaa gtgctcaaag
     3721 accagaaagt cttttccaat cagctagtct gccggcgcga cgtcttcgca tggtgtgcgc
     3781 gctacaacac cacccgaagg cattcctggt gcaagtacct cacacccatt gagtacgaat
     3841 ctcaagcttc ctaacaatgc gctagagtaa agccaataat ttcaccccca cggtgtctac
     3901 tttccggggg ccgggcccag ccaccgggtg gaaacaagcc atcaaccaac tagccgtggc
     3961 ataccccgac cgattcgcgg actacttgta aaccaagccc ccgcacacaa acaatcggac
     4021 accctccnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6421 nnnnnnnnnn nnnnnnnnnn nnnnnnggta tcgcgatggc cgcgtccata gcggtagtac
     6481 cggcgcactg ctcgttgtga ttttcggtat gccccctgtt cggcgtacac gagagtgcgg
     6541 cattcacgga agggtccgga ggcaggagcg aataagcgag gaaaccagtc gtgcttctgg
     6601 tgggcgtggg gcgtttcaaa aggtgcagat aactcgtgtt gttcaaacca gcaagggggc
     6661 atatttgaac gaaaatccct tgtcagggtc ctttttccgc ggttagatca atggtcgatg
     6721 gagcgtccgg atggtgccag agcacacgct ttagcctcgg tccagcttcc atctactttc
     6781 tcaccacatc acacctcact acctagattg gagtaccaaa atgtctgatt tcactcttga
     6841 cttcgccgag ggcgacgctg ccgacaccgt ttccccgcag atcacgtcca agtccctttg
     6901 caccccgggt tgcatcaccg gttggatgat gtgcaacacc gtcaccaagg gttgcagctt
     6961 cacgattggc aagtagcttc attgccgagc gtctgtcttt caagcctcta tcctgcagca
     7021 tcaagaaatg attctgcagg cagcttgagg gggcagtacg cggcgacata ggttaccccg
     7081 gttactcccg cgatattttt agctagcggg gatagccggg gtaattgtct atatctatct
     7141 ctgatctgcc ccgaggttga tcagtagaaa taatccggag gattgcctgt tatgcccttg
     7201 tttgaaactc aagcaagaaa ccgtatcgaa gcaccgtcta agccgaaggc ggttccggtc
     7261 gcactggcag tagcggccgc gatcgcgctg gtggccgcct tcttcagcat catgagcggg
     7321 gtggcaggag ctgtcctcgt tatcgcctca tttatctgcc tcgtcgtcta cttcgggcat
     7381 cgcccttcac ggaagtactt gtcgatatcc ttggttctgt cagtactctg tgttgtcgtc
     7441 gctgcagtgg gacttctcat gcagctttcc gatgtgcaag cgcactgctc ctggatattt
     7501 ccccagggtt ctccagctca tgtggcttgc ttccaggaga actactcgcc ctggcgtggt
     7561 gcagcccagg ccttatttcg atagcaggca ataacccact gccgctgggt attaggttga
     7621 ggcatacacc cgccgatcct gctggcgacg actggcagga gaaggttctc ccgctaatca
     7681 gcagatgcct acgatttgtt cgatgtcgtt ggagtaccta gccaaatcct cggcaagggt
     7741 gacgttgctg gtctgtgaca aaccagcgac aatgcctacg actgttttac gtccatcgac
     7801 atcagccacg aagacgccgg ctccggagtc gcctcctctc gtgagactcc cgtccgcctg
     7861 gggaaccaag gacagcatgg ggtggactcc ggcaccggcg gctgggttac cggccaggtg
     7921 atcattggcc tggatggtaa acggcagggc tgccacccct ccgtagtccc ggaagacgta
     7981 gacctcggct gttgtgccga cctggggaga ggagtcgggc aagggtgtgc agcctacgtc
     8041 cggacggtcc ccggcgagac gtgccacggc caggtcagcg cctggaatct ggtgtacttc
     8101 ctccacaccc gaacgggcac tggtgaaaac cgtataggcg tcgttggtga ggtcctcgtc
     8161 gaagcaatgg gcggctgaca gtatccagtt ggggttgagc gttatgccgg tgcaggagga
     8221 aatttcttgg ccgtccacaa tggcaatggc tgcgagcgaa aaggagtggt cgggagtctc
     8281 ctcggttgaa gggggttcgg agggggaatc ggtcggggcg gtgatctggc ttgaggacaa
     8341 ggcaaagggg gaggacgaga tggaggggga gacccccggt gcggggacag cctcgtcggc
     8401 aagggaaacg gagggtactg ctagggatgc tgctgccaaa agtgcgagac tgattcgttt
     8461 tttcatattg cgaagttcct taatctatag gtcttagtag gtgccgaggg ttccgttgac
     8521 ccgtactttg tgtacgccct ttcgccacat caccactcca aggggaataa gaagcgcggt
     8581 ggtcacgatg gttggcatca aagcctttag gacctcaaaa gtgggggccc cggaaaagag
     8641 cgatagacgg atcgagtgca gcattccagc cgtggggagg tagctagcgg cggatgccac
     8701 cacgtcgggg aaaacagaga tcggatacat aaccccagaa aacagggtca gcagtgtcgt
     8761 taccacccag gtcacgggtt ctccctgctt ggacaccaag atataagcgg ccgcgcacag
     8821 tccaattgcc cacatgcaca ccaccgtgaa cgcgaccgat acgacgaggc caatcgggtt
     8881 gagtttgagc tcgaagtcga ataggtggcc aaagatggtg aaaatggcta cggaggaaat
     8941 caaagtcatg accaggccaa acacgccgcc agcgatcagg aacttgaata ggccggctcg
     9001 agacagggcg atggcttcta gcgttccccg cttttgctcg gactggatct gcattttcag
     9061 ggagttcatc atcatgacgg ccagggcact aaagaggctg ccaacgatca tgaaggcgat
     9121 gatgtttcct ccgtattgct caagacccgg aggcgtcccg ccgagggaga tgtagtaacc
     9181 caggatggca aattgcgcga gccccacaac tccggtcaga agacccagca ccaactgggt
     9241 gcgataggtg attcgctctt ggaaagttcg tccgacttct gcgtagaaaa ccagagagaa
     9301 agatttaata cggtcgaagg ttctcacagg gctaccacct gatcggattg ggcgatgagg
     9361 ttctggtcgt gagtggagat caagacagtt actccacgcg cgataaccca ctgcatcatg
     9421 gtcagtgcgg cgagggaatt ggtggtgtcg agggtggcgg tgggctcgtc gagaatgatg
     9481 agatcatctc cgatgacaag agcgataagc atcccgaata tctttcgttg acccagtgag
     9541 aggtctgaga aatgccgttc gagtagtgga tcaacggtaa attcctggcg caacggagcc
     9601 agccggttca gggtttcctt tttgcgtagt cccgcgagcc ggccaaaata gatcaagttt
     9661 tgcaggccag tgagtcggaa atgataggaa cgctcggagt acaagctgac gccgagtcgt
     9721 tcgcggatcg aggaccagtg tttttctgtc gattctccgt caatgaggac agatcccgag
     9781 gtcggtaacg agatgccgca ggcgagccga agaagcgtgg tttttcccac cccgtttgcc
     9841 ccggtgatgc tgcacaaacc ggggccacga atctgttcgt tgaagcccga gagaatggtg
     9901 gtcgtcccat acttcacgga cacatctgtg aaggtgatgc gagtggtgct cggggtatgg
     9961 gcaggggtgg caggggagga cgcggggcgc gtaagggtgc tcacttcttt acccccagga
    10021 tcgtgagcgc gggtgcgtag ccgtggctgg attctcggcc agcccagaca gcggtggtcc
    10081 cgccgatacc gtgccagaag ctgaggtcaa cccccgtgct gggtccggac aggaagtggg
    10141 tgatctgatt ttcgacgtgt tcgagccaag acgcagatgc cgcgaaacct agctggtcag
    10201 caaggtactg acgccccgcg actccgtgac agagtccgga atcattgaaa gaaccgagct
    10261 gggggtcgaa gtagtcttcc ccgtgaacga gtgaggagtt cagctgttgc tcgagcggtt
    10321 ggcaaccggc ggcggagatt tccgcactag gagtgccata gcaccatgcc tggcgggatt
    10381 tggtggaggg acgcgggggg ttactggcgg gagagggggt ctggaagtag gaaggcccac
    10441 tgtggttgtg ctctgctatg tctgcaacca agacatccat cagcctggtt gctgcagtta
    10501 agtaggaggg atcttcaaag accttgtggc cgacctttaa gacggcgatg actcccgcga
    10561 ttccatgagc aaaccccagg tcgcgcatgc cgttgcccag ttcgggggtg tgttcgacca
    10621 tcgccgggtc taagtccgca gcaccagtcc agaatgaatg gggaagtggt tgcagcgata
    10681 gctcagcgaa ctcgttgcag atctgctttg cgagacctcg gtactgttca tcagcgacaa
    10741 agaggtaatg agcgatgccg gctaatccca ccgcatagtc atagtcttct cgacgcttgc
    10801 cgatactgcg gtgaaggtcc cacagttttc tctcagcgag agtcgagata cgcgagttga
    10861 ggctgctcag cgcgttactg aattcttcct cattgtgcct ggagacggtt aacagatagg
    10921 ccatgccgct gagaccgccg agcagtcccc cttgatcaaa tcgatgggta cgtagcactt
    10981 ccaccagagt gctaacccgg ttcatcaaaa gatcccacca cttctgatct tcagtggcgt
    11041 ggtacaaggc cgatgccgtg taggcgtcgc cgagagcgcc atcaatcatg gaaaatggag
    11101 aatgtgagat cctttccgtt cgatgatcgc tgctaaggcc ctcaaaaagg tgggcatcaa
    11161 gatgctcgag agcgatgggg gtgcgtgtcg ttggcatggt gatttctcct ttcgattttg
    11221 ctgagagcag cccagagagc cttttcgcgg tcggtcgaga tgcccacacg gttgcagaac
    11281 aagtgggcag cggattgcag ctcataggtg cccacggaat gagcggaaat tttgttggcg
    11341 agacttttca tatgagccct aatggaaggg tcaatgaggt cagcggaagc gaggtctccc
    11401 agggagtcgg cctctcggag gagtgcggag gccgccttct gtactgtgct gctgtcctcg
    11461 ctttggacag cgaactccac gatcacactc ctgtaatcgg ggaagagatt gagccacctg
    11521 tcgagtatcg gaagatgcag cctctcgtcg atggtgtcgg tggaggaagc cgcagacagg
    11581 tgcgcaacga ccctgctttc taacgagaac agctccgcaa aaagcgggaa aacagccggg
    11641 ccgccgtagc gttcaaattc aaggctatgg gccttttctt caagtccgag gagccagccg
    11701 ctgctggtca tctctcggat ggctgtttct accgcggctc ctgtcgaggt gcgacgaggg
    11761 tagcgaaggc gcaggccgga ctcgccggaa tcagtggggt atcgaatgaa gtaggcgccg
    11821 gcggcagttt cctctgtcga gaagagccgg cgtatgactc tttcgcgaaa accatcccgg
    11881 ggaacgatgg tgagattggc ggtgtcgctg atgccgggga taagttcttt gtcctggttg
    11941 gtggcaacga ccgagaggct ttgggctgtg gttcgcagcg catcaggatc gggcgctgga
    12001 ctggagatcc caaatgtcag gcagatttcc gagaagatgg gacggtcctg gtggtcgcgg
    12061 accagggggg tgagctcgga atcgaaggat tcatagaccc atccgtcgct gcggcgcagc
    12121 tgcgatcgaa cggcttccga gaagccagga gcggtgcgtt ttaagagtat cttcctgtcg
    12181 gaatccccca tcctgaccca ttcggatatg ccgtggctgt ccgcccactc gttgaaggca
    12241 ttgacatctt ctaggccgcg atagcgaaag gccggccggg agacgataac gcggccgtgg
    12301 cggacaccag ggaggtagtc gacgtgatcg ctaattgttc cccaggacca gttgatattg
    12361 ggggtggaac cagtggccgc catcgcaatc tgcatcagcc actcgggata ggcgcccacc
    12421 ccgaccatgg aggtcggtcg gaaccggagg ggggatccgt cttcgtcgca gaggtggacc
    12481 tgggtgccat cactccacac ctggagggaa tcaagggtca gttcccaggg atgggattcc
    12541 accgagttga cgttgagagt gcgcgggtaa gaggtgtgga actcccgcac gctgttaaac
    12601 gcctgctgag gggataccnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    14941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngataccc agtcgatgtt gattgcgtat
    15301 tcgtcgttaa gatgacggct gggcaggaga tcgaagcgtg cactggctac gccgccgggg
    15361 atactggaaa tcgcgtcggc aatgttatag gtggggtcgg tgggggtccc gtggagtgac
    15421 gcgatgagat cgagggaatc gaagcgagaa taggttcgtt tctccctggg gagcgaggcg
    15481 gcctcggatt gaaggtcaac ccagccatcc gcggatttga tgcctcgggt gtagacggaa
    15541 cggaggtagt cagaggagga ttttgtcgcg gtcaggctgc gggcctgggg agaggtggtg
    15601 acagttttcc aatccaggcc gaagacggga tggatcaggt gtgtcagcgg gatcctcgag
    15661 gcaccatatt tttccaggag tagttgtgcc aggacctgcg cgagtccgct gtcgttgtat
    15721 tcaaaagctc cgtgggtgaa accgtgttcc aggaaggctg ttagttcttc cctcatgccc
    15781 gtcggagggg ctcccacggc agagcggtag gaatcaacat cttcatctgc gtattcagtc
    15841 tgtgctggta ggtgattctc gtcagcctcc agggcgaatt cttgggtaaa taagttgcgc
    15901 tgggagcggt aggtgtcgta gccgatagac ttttcggaga ggagaaattc atgtttgacc
    15961 agctggtgaa tcaccttctc aatactggcc atgtccgcgt caggataagc attgagaatc
    16021 gttgcccgca ggtcctggcc ggaaatgggg gttttagccc aggcccgtat ccctttgatc
    16081 aaagggttga cgcccacgga actgaacaca ggagtcgatt gactgcgggg agcggtgatg
    16141 taacagcgct cgtccatgat cactgccgaa ggattccatc ggagaatcgt gccttccgcc
    16201 ttcttgtcat cagccacgat cgatgagcgg gaagctgtga tcgtcagcgt gggttcgagg
    16261 gtaatttcac cggggacgtt ggagggcgac gaagatattt ctcccacggt gctgatcatc
    16321 cgagaggggg tagcccttcc tgctgaacgg gctataaggc cagagagcgc ccgggcggtc
    16381 ttccggatga ttttgggacg ttgctccgag ccgtcaacaa tttgagaggc attggtgact
    16441 atctctggat ggaaggtgtt gagctcggcc cacaggaggg ggtgccgccc cgcaaggcgg
    16501 agcaggtcag tgactgttgt cgcctcggcg aggtcttcca gaacggtgat atcagtggat
    16561 gcagctcgaa taatggggca tccggtgggc gctgtgaccg agacacttgg tgtcgaggac
    16621 ctcgaaggcg tcttcaattt cgctcctgta catgttgggc tgggctgcga ggaattcgtc
    16681 tcggagccgg gtagtgaggg attcggcata ggggtcggtg ctggaggcaa acggccatcc
    16741 attaagcacc cagagggctg cctgggggtt tccctggcgg agatagttga cagcgacgtc
    16801 atagtcgaag aggaccgcgt catgtaggac caccgagcgg gttactttgt cgtaatggat
    16861 gtcaacgcca gattcctggc acaccttgag cgggtaccac aacgaggatc gcgagcagaa
    16921 ccccccgtag agcacctttt cgatcgtgct ccgggccagc cgtcctcctc cgctggcgac
    16981 catgtgcaag agctgggccg cccgggtact cgatacttcc ttgccgttga tgcgtaatgt
    17041 tccggtgatc tgcacgaagt gccgtcgtaa cggcgccacg ggctgactgg cgctgtcaat
    17101 taccgcgttc atgtcctgtc tttctgcttg tcgtagagtg tgaaatcagc cacggcgttc
    17161 tgagccgcgg atctctcggg tggcccaaac agtgctgcca ctgatgagca atgcctggag
    17221 cactatcgcg ataacgaagc gggcagcagt atccgctgtt tccggccagg acggcaccgc
    17281 caccagccag agcaccgtct ccgcgaggac gtctccgcct aaagtggccg agacaaccgt
    17341 ccacagcacg gtcgctgcga tagctacccc cgatccgaat cggatccgta gggcggtcga
    17401 gaccatggtc aacaagattc ctgtcagcgc ccacagcacc accatccgcg cagtttgagt
    17461 gagatcaccg ccggccaaca gatgggcacc accagtacct accgccagca gtaggaggag
    17521 aatcgcctgc caggcaaggt aagcaccccg gatgcggtga ttctcggtta cggcaatcgg
    17581 ccaggcaccg gagagcgccg accaggtcat cacggggagc agtcccgcgc ccaagggcag
    17641 aatcgcgaag gtatacaacc cgctgacgta cccgggggga tagattagcg ccactgcata
    17701 aacaagaact actgcggtga tggccagggg agtcgcggcg gtgcggctca ggggcctgtg
    17761 gactgctgct aggacgttga gcaaagactg gttttctcga acattatgct caccgcgtat
    17821 gtggacaacc gggtggtgag aaagaccggt cacggaggga tcaaccgtgg catgtttcgg
    17881 gtcgtcaccg tcatctgaat ctcgcctgtg ggggttaggg cgtttccctg ttactcgttg
    17941 gcccctcaat gcaacggcca aacccactgt gaccacggcg aaagcaagat tgagggcgag
    18001 gccagccacc ggggattcct ccgcgagtgg gtgcccggtc tccagaggaa cagcgttgga
    18061 gtggatccct agtgtcggga gcaagaggcg gactggccag gcgggtggaa aggcccacca
    18121 ccagctagct tccgcggtca aggtgccggc aacctgataa accaccgcaa ccaagagagc
    18181 aggaatcatg ccggtaacgc gcgcgacgat gctaaacaac gcgatggtcg agatgctccc
    18241 gatccaggag agcgcacccg cactgaggat tgttccggcc cccgcacggt aatcggcaac
    18301 cgcataaagc caggcaacac cgaaattgag caggtggaag acagccgaga gggcgatgag
    18361 aaccatcaac cgggccgccc tcgtcttgat gggggagacg gggcggagat tggttccgcc
    18421 gtagcgtgcc ttcttttccc tggtttcggc cagacccgcc aacagggcaa gaataggggc
    18481 cgccatgccg gtgatgtaca tggcctgcca gctcaagatg cctgaggcat catgagcgcc
    18541 agacgaccag agggaaaacg tcgagctgag aaggccgatg agcaacccga tcaggggaaa
    18601 ccactggagg gcagaggatt tgagacggat aagctccgcc cggatgacac cgggccaggt
    18661 gcccgcccgt gcgaggtgtc gggctcgaga acgtgcatga atggtcgccc cggtcatcgc
    18721 gttgcccctg ttgagtgggt catacgcaaa aactcatcct caaggcgatc tggatcagcg
    18781 aaatcatgca gaggaccgga ataggcatcc cggccattga ccaggacggt gatatcgtcg
    18841 gtcagccgtg cgacctctcc cagctgatgg gagctgacca gcacagttcc tcctcctgta
    18901 gtccagctcc ggaggaaacc ccgaagatcc acgattccct gtggatcaag gccgttttga
    18961 ggttcatcca gaaggagaat gggcggtgag cccagcatgg caattgccag ggcgaggcga
    19021 gctttcatac cggtggagaa atcccgtgcc ttctttcgtc cggtttcttg cagtcccacc
    19081 atgctcaatg ttcggtcggc ctcgtccgtg ccgagcccaa gcaactgcgc atgaacgcgg
    19141 gcgttatccc tggccgacag gtgcggatac aaagcgggtc cgttgatgga ggcgccgatg
    19201 ttgatcaagc tgtcccttgt gcgttgtgca ccaaggattt ccacggtccc ggttccgcga
    19261 tcttcgagtc ccaaaatgat ccgaaagcac gtggacttgc cggccccatt cctgcctagc
    19321 aaggcgtgta cccggccagt tttgacctgc atggaaaaac catccagtac ttggtggccg
    19381 ccgaatccta tccggaggtt gtcacacgat aaagccactg tgtttaaggc tgtagaggtc
    19441 acaaacccca taatcgcttg ctgaggcaag tgagcgaatc cgtctcaaga acgaaatttt
    19501 tgtccgcccg ttcccccggg cgggggaatc ctctcctatt tcacggcttg tgaactctgg
    19561 gcgctgacaa tgccggaggt gtgagcccat accgctagtc cgacgcggtc acgtacccct
    19621 aatttggcga tcaaccgcga tacataggtt ttgacggtgg ctgccccgat gtggagatgt
    19681 gcggcgattt cagcattggt ctcggcgagc gccacccgct ccagcacttc cagctcacga
    19741 ggcgtcaacg gctcaacagg aggggctgtc gtggtggatt ccgctacgca agagtcccgg
    19801 aagccgttga tgacgaactc ggtgatcccc ggggagagga cggacgcccc ctgatggatc
    19861 ctccgtatgg catcgatcag agcttccggt ccggagtctt tgagcatgaa accctgtacc
    19921 cctatttcca gtgcccggcg tacgagatct tcggagtcga aggtcgtcaa catcaagacc
    19981 ttcgtggttt cacggcgctg tcggatgatc tgcgcggcct cgatcccgtt taggtggggc
    20041 atgcggatgt cgaggacggc gacgtcaata cgccaccttt ctgcagcttc aatggcttct
    20101 cgtccgttgc ccgcggtcgt aacgacctcg atgtcgtctt gggtgttcag aatagttttg
    20161 agggcagtga tcatcatggg ctggtcgtca gctaccagca cccggatagg gcggtcattc
    20221 cgcgtttcgg aaccctgact tccgtgtgcg tgctccatta ctttctgcaa cccctcttga
    20281 ttctattgac cgacttctta cacctaacac ggtgagatcg gcaatgacgc ctgcacacgg
    20341 aagtatccct gcctggaatg gtattgaatc tgaccattga gactgtccac gcgctcctgc
    20401 attccgatga gaccgctttt tgtgcccgtc agtgcaggtg agacctcatc ctgtactccc
    20461 ggtgaccagc tctcgatatc cagcgtgatt tcgtcgtcct cccagtcaac ggaaatatcc
    20521 acctccaccc ggctgccgac cccttggtgg cgtaccacat tggtcaagga ctcgttgagg
    20581 atgcggcgaa cgcccagctg gacgataagc ggggacgaag atgatatttc ggccaggtct
    20641 cggtcggagg ggagcgaggc agtgatctcc attccggttt tccggtactt gtcaatctgc
    20701 tcgacggcac tggcgaggtt cgttatctca tctaaggaga tggaatctgt ctcagaacgc
    20761 agtgctttga cgatccctct cacctctgcc aaggcagaag aactggtgtc ttggatgctt
    20821 tccagtatct cttcgtgccc ggcatggtct ttcgaagggc gttgacgggc caccattatc
    20881 cctgcagagg cctgaacatt tatcaaagta agactatggg caagaacatc atggatctct
    20941 ctggcaattt ggactcgttc ccgctctcga atggcagatt gttcctccag ggcggcatgc
    21001 tctcgattgc gctgctgttc agcatggcga tcttcttctc tgcggcggtt gatcgcgatc
    21061 tgccggatgg cggtcaggcc aagccactga atcagtaacc aggagagacc ttggtcgctg
    21121 ctgtgataga gcattcctga ttcagtctgg taccacatga tcggggacac aaagcagtac
    21181 accagcgccg cggcataaaa gaggaaggag attattcgtc gctccaagaa tcgtgctgtt
    21241 gtatacacga taatcggcat gaccagcacg aagggagtga accccaggtt caagggaagt
    21301 gcggaaaacc agtttgcggt ccacaaggcc atgagcaaga gcatggcgac cgatgacgcg
    21361 gtcggtcgcg tgcgccaaaa gagcaacgcg gggatgaaca agatggctaa tatggcctgg
    21421 actatttctt gctgagatcc gttagtggcg atcgcgccat aaataaaggc cagaaaagta
    21481 gccagaacgg cgaagcccca atcttcaatg tgagaaggga ttccccgcag cgatgcactc
    21541 atatcccatg acattagaac atgggcgttc agtaggtcgg attcggtata ccttgtcacc
    21601 gaccacgaat ctgatttgag gaggacgatg cagggggaag gtttactggt gctgcnnnnn
    21661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    22021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    22081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    22141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    22201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    22261 nnnnnnnnnn nnnngtgacg accggagaag atgcccatgg ctgtgattat ttcacgtagg
    22321 tcttcctgtc gcccgaactt tgcaacagca ccggtcttcc tgtcgcccga actttgcaac
    22381 agcaccctac tacgtcagtc aatttgtcga ttttgctgat gagctcttcc tcaattttgt
    22441 agatctggcg gtatcttttt gcgagagcct tttggcggtc caggaggtgt gcccaattgg
    22501 attacaagta cctacacact tgatcggtgc tgcacgtttc agggtccggg tgtgcggcgt
    22561 cctgtctaag gtccgcgata gtgtcgcgca gcacggagag ctgcgcgatc tgctgctcga
    22621 tctcagcgag gcgcacgtca agcaggtcgc gcacgtgctc gcagggcgcc tggccgccgt
    22681 cgcggatgtc gaggatctgg cggatctggg cgagggtcag cccggcggcc tggccccggt
    22741 ggatgaaccc gacccgaccc acggcattct cggcgtagtc ccgatagccg gaggccaatc
    22801 gctcggccgg agggagcagc cccgactcct cgtagaaccg cagggtcttg gtcgtggttc
    22861 cggttgcttc cgcaagctgt ccgatcctca tgttcgccga ttccccttcc aatggccact
    22921 acacttgacg ttccattgta ctggaaggtt cacaatggtt ccataggaac ttttgaacca
    22981 cagggaagag acatctggaa tgacaaacga aaagttcgat ctggcgatta ttggttccgg
    23041 cggcggagcg tttgcggccg cgatccgggc caccgggctg ggcaagcgcg tcgtgatggt
    23101 ggagcgcggc accgtgggcg ggacatgcgt gaacacgggc tgcgtcccgt cgaaggcgct
    23161 cctggctgcc gcggaggccc gccacgtggc gttggattcg gcccgcttcc ctggggtggc
    23221 ggcctcggcg ggcccggtgg acatgccggc cctgattcag ggcaaggccg cgctggttga
    23281 aagcatgcgc acggagaagt acgtcgatct ggccgcggac tacgggtgga cgatgatctc
    23341 gggggacgcg tcgttcaccg gaacccagga cgcaccgctg ctccgggtga tctccccgga
    23401 tggtgcagtg agaacgatcg aggccgggca ctacctcgtg gccactggct ccgcacccta
    23461 cgtgcccccc gttcccggac tggccgaggc cgggtacctg acctcgacga cggcgatgga
    23521 actggacgag gtgcccgaat caatgctgat cctgggcgga ggctatgttg ccctggagat
    23581 ggcacagctt ttctcccggc ttggctcccg ggtgaccatg ctggtccgtt cccggttggc
    23641 ctcgcaggag gaaccggagg catccaaggc attggcgggg atgttcgccg acgaggggat
    23701 ccgggtggtc cggcgggcca tggccgactc cgtggcctcc ggcccggacg gggtctcggt
    23761 gacggcaaac gtggccgggg gcgaggaggt gttccgcgct tcccacatcc tcgtggcact
    23821 gggccgccgc ccggtgaccg agggactgga ccttgacgcc gtcggggtga agaccggcgc
    23881 atccggcgag atcgtggtcg attcccgcct ggccacgtcc aacccgcggg tttgggccgc
    23941 cggggacgcg accggccatc gggagttcgt ttacgtcgca gcggcccacg gcgccctggc
    24001 cgtggacaat gcgttcaccg atgccctggc cgaggtcgac taccggcacc tgccccgggt
    24061 cgccttcacc agtcccgcca tcggggcggt cgggatgacg gaaaaggaag ctgtcgccgc
    24121 cgggatcagc tgcgagtgcc gggtcctccc cctggagtac gtgccgcgag ccgtggtcaa
    24181 ccgcgacacc cgcggcttca tcaaggttgt cgcggaccgc gacaccggac ggatcctggg
    24241 cctctccgcg gtggccaagg acgccgggga aatcgccgcc gccggcgtct acatcctcga
    24301 agcgggcatg accaccgcgc aggtcgccgc cgcctggagc ccctacctga cgatggccga
    24361 gggcatcagg atcgccgcca aggccttcac caccgacgtc tccaagctct cctgctgcgc
    24421 ctgagctgca gcccccacta ccgaagcaaa cgaggcgccc gcctatcagg acaggttggt
    24481 acagcggcat caggccggaa gtcaattcgt gcagagggct tcgggcaatc cgtcaggagc
    24541 cctctgtacc gcccccgcaa tgacgggaac gtcagtgtgg tggacttcgg aaagccacag
    24601 tgacacccac tagttgtact cgaccgtgac gttggtggca ctttcggtct tgtgaaatag
    24661 ctaggcctcc tggcttagtg gagctgtcta gttcttcact gccaggaggc ctctatgccc
    24721 aacggtaacg cccgcttgac cacgcatgcg agagcgttgc tggtggccag gcaagctcat
    24781 ccatatcgat gtgaagaaac tcagccgcat ccccgacagc ggcggttggc gagtccacga
    24841 ccgatccgcg accggaagac ccgatcgggt tcgaccacgt ccatgccgct gtcgatgacc
    24901 acacccgact cgcttatatg gcccactagc ggtcgcggag cgtcctgaaa acctaaagtt
    24961 ttatgagaca cccggcagga actggaatgt gagaccgttt catggggcaa ttggcctcct
    25021 ccccgtctca ctaaagcgtc tcgccctaag ttgtcgcagg gtggtgctcg gtaggggttt
    25081 gtgaggcata atcgagacat gaggcttttg gggtacacgc ttgcggacag gtacggcccc
    25141 cgccgaacgt cgtccatcta gggttcactt ggttgttctt ggacacgttt ctactggggt
    25201 ccagactctt tctggacact ctgcggaggg cagacacaca ttgtgactct caacttcatt
    25261 tggcgggttc tctcaccttc gcatggcgga actctcggcg attcggagag ctccgagctt
    25321 tcgaggtctc tcaggcactg cactaccgag gccccggcag taccgtgtat gtgcgaacac
    25381 gtcagctgct cagcaacaat gtctcgccga tctcgtcgag ggcgagggtt gtggctccga
    25441 cgaggaagag cgcgtgatct tgctcgcgat caaagccgat ccagctcgag aatcctccgg
    25501 tacgtccgtt atgccaggtg atggtttgtc cctcgattcg agaggtcatc catcccgcgc
    25561 ccacgcggtc tgccccgtca gtcgagaagg cagcgactgg gttaagagcg gcggcgcccg
    25621 gtgcgagacc ggtcaacagc gcccgcgcaa ctttcgccat gctcttcacg tcagttcgaa
    25681 taccaccggc aggcgcatat tgcagatcgg tccatgcctg ctgcggccgc ccgtttttgt
    25741 ctttgccctg tacggcctgc tcatccagtg ccgcttggcc ctctgctggt atgtagaagc
    25801 gtcccagctc gaggggtctc gcaatgcgct cccgcagcag ttcggcatag tccattccgg
    25861 cagcggcagc gagcgcgtgg ccgagggccg caaaccccag atttgagtaa gcaggctcct
    25921 tcgctccgat cggcacacgg cgcagatctt caacaaggtg gacgagggtc ctcccgtcga
    25981 agggattcct tgcctggatc gtcctgatga tgatgcgagc tatatctgtc atccccatcg
    26041 gttgtgctgg caggcctgac ctgtgctggg acaactcttc taacgtgatg cctgccgcgc
    26101 cgaagccctg cagctcgaac agttcaccga gcgtcgttgt cggaagaacc tcttcgcgtt
    26161 cgatggcatc gagatagagc atccccgtga tgcccttagt gattgatcca atttcaaatg
    26221 tcgcggccag cggggcgccg acggtcgcga ttcgagaacc gctccgtgtc accgaagcga
    26281 tccccagggc gtggacgcct ctggtgggca gaagctccag cacttgtgcg gcgagggcgt
    26341 cgtcaccata aacagtctga agcggcgagc ttgagcactt cctcggcgct tcagactgtt
    26401 tgcggtgctc atgcaagagg tgaccgacgg tgcccgtgct cacgcccatt tcgtcggcta
    26461 tctctcggta ggacttgccc tcggctcgga gggcggccgc gcgctccctg cgagcggccg
    26521 ctcgctcgat caccgcactg cgcggttctg ctcgtaggcg ccggacgttt cgcg
//
