LOCUS       NZ_GG657757            10945 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces viridochromogenes DSM 40736 supercont1.1, whole genome
            shotgun sequence.
ACCESSION   NZ_GG657757
VERSION     NZ_GG657757.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces viridochromogenes DSM 40736
  ORGANISM  Streptomyces viridochromogenes DSM 40736
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8653262)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Annotation of Streptomyces viridochromogenes strain DSM 40736
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8653262)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
REFERENCE   3  (bases 1 to 8653262)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Arachne v. April 2007
            Genome Coverage                   :: 8x
            Sequencing Technology             :: ABI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000158955.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 10:17:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,837
            CDSs (total)                      :: 7,762
            Genes (coding)                    :: 7,256
            CDSs (with protein)               :: 7,256
            Genes (RNA)                       :: 75
            rRNAs                             :: 6 (5S)
            complete rRNAs                    :: 6 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 506
            CDSs (without protein)            :: 506
            Pseudo Genes (ambiguous residues) :: 0 of 506
            Pseudo Genes (frameshifted)       :: 293 of 506
            Pseudo Genes (incomplete)         :: 267 of 506
            Pseudo Genes (internal stop)      :: 21 of 506
            Pseudo Genes (multiple problems)  :: 72 of 506
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:49:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4468196
            Orig. end                         :: 4479141
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GG657757.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation was added to the scaffolds in August 2010.
FEATURES             Location/Qualifiers
     region          1..10945
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="15"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10945
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10945
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5945](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5945)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    570..590
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.79"
                     /tool="antismash"
     misc_feature    complement(630..644)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(633..648)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            1112..1771
                     /locus_tag="SSQG_RS19640"
                     /old_locus_tag="SSQG_03967"
     CDS             1112..1771
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985061.1"
                     /locus_tag="SSQG_RS19640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03967"
                     /product="response regulator transcription factor"
                     /protein_id="WP_208865718.1"
                     /transl_table=11
                     /translation="MRVDRPLRVVLAEDSVLLRDGLVGLLGRCGHEVVAAVGDAEALVT
                     AVGEHDPDVVVTDVRMPPGFQDEGLHAAVRLRGERPALPVLVLSQYVQRRYAAELLDSG
                     DGTGVGYLLKDRVGQVEEFIEALGEVADGGTVVDPEVVRQLLRRRRDPLERLTPREREV
                     LALIAEGRSNSSIARELVVSEAAVGKHVSGILTKLDLPPADGTHRRVLAVLAYLRA"
     misc_feature    complement(1796..1810)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.63"
                     /tool="antismash"
     misc_feature    complement(1805..1821)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.48"
                     /tool="antismash"
     gene            1870..2565
                     /locus_tag="SSQG_RS19645"
                     /old_locus_tag="SSQG_03968"
     CDS             1870..2565
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032569.1"
                     /locus_tag="SSQG_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03968"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_003991558.1"
                     /transl_table=11
                     /translation="MTKQDRAVRTRLALIRSAAEHFEARGYVRASLAEISAGAGVSAGA
                     LHFHFVNKAAVAEAVEHVAARALRRAAARGRGGDGCALQRLVDVTHHVGRLLRADVVVR
                     AGLRLNAEAVAGRVRDLRREWRECVHELLAEAERKGELAAGVPPHRGIAVVLAATTGIE
                     VLSRDDHGWLGRHSLTDLWHLLLPCVAAPHVAVALDPAGSGRHLVEPDADADTDAPQGD
                     TNRAGLALR"
     misc_feature    complement(2662..2682)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.88"
                     /tool="antismash"
     misc_feature    complement(2737..2747)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            2742..4082
                     /locus_tag="SSQG_RS19650"
                     /old_locus_tag="SSQG_03969"
     CDS             2742..4082
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032564.1"
                     /locus_tag="SSQG_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03969"
                     /product="cytochrome P450"
                     /protein_id="WP_003991559.1"
                     /sec_met_domain="p450 (E-value: 8.7e-17, bitscore: 59.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQQACPFLTIEPSGQDLYGEISRIRDQGPAVEIELPGGVRAWWI
                     NGLELNKRLLAGPETSKDAFQHWPAWINGDISRTWPLAIWVSVRNMVTAYGSDHSRLRK
                     PMAAAFTKRRVDALLPRVQEIVDRALDDLERIPAGEVVDLRAAFAAPVPHEVVCELFGV
                     PRGEDGPRRALYRIIDSFFDTAISLEDAQANAVDLYGTLTAFLQDKREHPADDLTTALI
                     AARDEGSLSEQELMDNLILLLTAGFETTVNLIDNTVHSLLAHPDQLELVRSGRVTWEDA
                     IEESLRFEAPGAMSGLRYAVQDIEIEPGLTIPKGDPLVVSFAGAGRDPERHGPDAERFD
                     VTRATSRDHVSFGHGVHHCLGRPLAMAEATAALTSLFDRFPRLALADPARPPKRLRSII
                     STGHQELPVLLHGRNPGPDLGPRAEEAGAIRKLSELRGTSGTKVPRA"
     gene            complement(4027..5004)
                     /locus_tag="SSQG_RS19655"
                     /old_locus_tag="SSQG_03970"
     CDS             complement(4027..5004)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (6-180). E-value: 5e-10.
                     Score: 30.8. Matches aSDomain:
                     nrpspksdomains_SSQG_RS19655_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032561.1"
                     /locus_tag="SSQG_RS19655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03970"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_039933165.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.2e-10, bitscore:
                     38.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVNVLITGGSGFVGSRVAAVAQGRPDVRVRHLSRRTHQGAAPGE
                     PVQGDPFRGEPGHGEVVHGDLLNPPSLRGVCADTDVLVHCATRIDGDAGTVEAVNDLGT
                     RALVEEAVRAGVSRIVYVSTAAVYGRGPFRGVRPGEVPVAPASATSRTRAAAERHVLDA
                     GGLVLRPHLVYGEGDRWVVPGLVRLLRELSATLTGCAALQSMIDVGTLGRAVVAAALSP
                     ALDGGVHHVNHPEPVGAAELLGAVCAQVEEPGGGAAVDVATALDRAAGTPFALHHLGML
                     TVDHWFVDDAFWKVLDCSPGDGFAAGFTRAAPWYRSFLAARSAS"
     aSDomain        complement(4465..4986)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSQG_RS19655_NAD_binding_4.1"
                     /evalue="5.00E-10"
                     /label="SSQG_RS19655_NAD_binding_4.1"
                     /locus_tag="SSQG_RS19655"
                     /protein_end="180"
                     /protein_start="6"
                     /score="30.8"
                     /tool="antismash"
                     /translation="ITGGSGFVGSRVAAVAQGRPDVRVRHLSRRTHQGAAPGEPVQGDP
                     FRGEPGHGEVVHGDLLNPPSLRGVCADTDVLVHCATRIDGDAGTVEAVNDLGTRALVEE
                     AVRAGVSRIVYVSTAAVYGRGPFRGVRPGEVPVAPASATSRTRAAAERHVLDAGGLVLR
                     PHLVYGEGDRW"
     gene            complement(5001..5945)
                     /locus_tag="SSQG_RS19660"
                     /old_locus_tag="SSQG_03971"
     CDS             complement(5001..5945)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032560.1"
                     /locus_tag="SSQG_RS19660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03971"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_003991561.1"
                     /sec_met_domain="AfsA (E-value: 1.3e-21, bitscore: 75.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIDPIEPPDIEPPDSTPVTKELAHRTVDTDVFPTRWCRISETRF
                     RFTAHWPAVHTFFHPVDDRHQDPMIVGETLRQASMVLAHAEFGAPDDTHFVMYDLTVFT
                     DPSALLLSDAAEPVEIDVVCSEIRRRGRGLHSMRTTMEFRRAGRLVARGTGSTACTSPL
                     AYRRLRAQRLTAPVTHLPLPPGIAPEVAGRARAEDVVLAPAGRPGVWRLRVDTGHPVLF
                     PRPNDHVPGMVLFEAARQAATAASGRHPFLPRAMTATFARYAELDTPCWIQTQVLDEEP
                     GQVTVRVEGRQEGKSVFSATLTCAQPARVRSLS"
     misc_feature    6112..6121
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.94"
                     /tool="antismash"
     misc_feature    complement(6113..6126)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.06"
                     /tool="antismash"
     misc_feature    complement(6114..6127)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.63"
                     /tool="antismash"
     misc_feature    complement(6115..6128)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.64"
                     /tool="antismash"
     misc_feature    6187..6200
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            6211..6903
                     /locus_tag="SSQG_RS19665"
                     /old_locus_tag="SSQG_03972"
     CDS             6211..6903
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032559.1"
                     /locus_tag="SSQG_RS19665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03972"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_003991562.1"
                     /transl_table=11
                     /translation="MARQERAIRTRRTILEAAAAVFDERGYTSATIGEILDRAGVTKGA
                     LYFHFGSKEELAVGVFEEQLSIALPPQSSKLQELVDSGLVLARRLRSEPLVRASVGLAL
                     DQGAMDLDRTMAFGMWFDQNVQRLAEAKAQGELLPHVDVAETAELLVGSFSGVQLLSQL
                     RCQRQDLERRVVVLFEHFLPSIAVPAVLARLDISAERAERVLAEGREQVGAVPAQASPG
                     AVRASSAT"
     gene            7083..8516
                     /locus_tag="SSQG_RS19670"
                     /old_locus_tag="SSQG_03973"
     CDS             7083..8516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032556.1"
                     /locus_tag="SSQG_RS19670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03973"
                     /product="DUF2252 domain-containing protein"
                     /protein_id="WP_039935205.1"
                     /transl_table=11
                     /translation="MTRAGAEGGTGAQDGTRRRLPRVRGFAEWPPEGSPKDEGKALRKR
                     IPRGAHATLDLHASRPDAVSAVEESNRGRLPELTAIRVGRMAATPFAFLRGAAGLMAYD
                     LAHTPMTRIRAQICGDAHAANFGLYGDPRGGLVIDLNDFDETVRGPWEWDLKRLVASLV
                     LAGREAGADEDRCRKAAQDAVGAYRRTMRLLAKLSVLDAWNAIADEELVSHTDAHDLVG
                     TLERISEKARRNTSGRFAAKSTEATEDGGRRFVDAPPVLRRVPDAEAAAVAASLEEYVG
                     TLSEDRLPLLARHAVHDVAFRVVGTGSVGTRSYVVLLLDHRGEPLVLQVKEARPSALVP
                     HLVTAGFEAPQAEHAGRRVVLGQKRMQVVSDILLGWTTVDGRPFQVRQFRNRKGSVDPA
                     ALAADQMDDYGRMTGALLARAHSHSVDPRLVAGYCGKSDELDEAMAGFALAYADRTEAD
                     HSDLVTAVREGRIAAEMGV"
     gene            8656..9471
                     /locus_tag="SSQG_RS19675"
                     /old_locus_tag="SSQG_03974"
     CDS             8656..9471
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451457.1"
                     /locus_tag="SSQG_RS19675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03974"
                     /product="hypothetical protein"
                     /protein_id="WP_003991564.1"
                     /transl_table=11
                     /translation="MTTPEAEQDGGDAARPEARLERAVRAAEQALIEYEIAVETFRVEI
                     ENFSRLHEQKLGPLYARLEELDARILEARAARSGDPDDRRRAEEARARLAPIPGVEELL
                     HGWMDDSGLFPESVAMLTDQAVRPPRRVRPSEEARKLYRDLARKAHPDLAQEEKERARR
                     EEFITRVNAAYARGDEAELRELAEEWAAGPELKWGPSRAEELYARLEWLAQRKELLALL
                     AKELEESAIGHMLQLAPDDPDGLLDEIGQQLRTQVTERENELAGLLTEG"
     gene            9537..9866
                     /locus_tag="SSQG_RS19680"
                     /old_locus_tag="SSQG_03975"
     CDS             9537..9866
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055193.1"
                     /locus_tag="SSQG_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_03975"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_003991565.1"
                     /transl_table=11
                     /translation="MPTVAVADLKDGDFLLDVREDDEWKAGHAEGALHIPLSDFVARYG
                     ELTEAAPQDGRVHVICRSGGRSAQVTMYLAQQGIDAVNVDGGMQVWEAAGRAVVTDDGQ
                     PGFVL"
ORIGIN
        1 gttgccgttg ctgctgggga cggctctggc gggcattccg gtggcggcgc tggagcggct
       61 caggctgcgg ctggtggacc cgggcccggc gcccgacccg catgagagtc ccggggaacc
      121 ggggctgagg gcctggttgt cgacgcggct gcgggaacgg gccacctggc gtgagttcgg
      181 ccatgccctg ctgttcgcgg gagtgttgtg gccggtggac gccctcgcgc tcgccttctt
      241 cctgctgggc ccctcgaccg tggtcgcgac cccgttggtc gtggccaccg ccggtgaggc
      301 gaaggtgctc aaggtgtggc tggtctccgg ttggccggcg gccttcggct tcgccgtcct
      361 cgggctggcc ctgctggttc tgggcgccta cctgctgggc gtcgcggccg gtgcccgggc
      421 cggtctggcg cggctgctgg tcgcctcgcg ggaggccgac ctgggggcca gggtggcaga
      481 actggcccgt tcccgggtgc ggttggtgga cgccttcgag gcggagcggc ggcgcatcga
      541 gcgcgatctg cacgacgggg cccagcagcg gctcgtcgcc ctgacgatga cgctcggcct
      601 ggcccggctg gacgccccgc ccggcccgct ggccgaccag ctcgacaagg cgcacgctca
      661 ggccggcacg gccctcgcgg aattgcgcga gctcatccac ggcattcacc ccagggtcct
      721 cgccgactac ggcctcgaag ccgccgtcgc cgacgctgcc gaccgctcgg ccgtgcccgt
      781 ggacgtaggc ctggagctgc ccggacggct gccccaggcc gtcgaggccg ccgcgtactt
      841 cgtggtgtgc gaggcgctcg ccaacgtggg ccggcacagc ggggcgagcc gggcggaggt
      901 gagcggcggg caccgcgacg gccggctggt cctgcggatc cgcgacgacg ggtgcggtgg
      961 cgcccgggcc ggggagggca gcggactgac cggactcgcc gaccgggtgt cggtgctcga
     1021 tggcagactc tccctgtcca gcccgcccgg cggaccgacc ctgctgtgtg tggagatccc
     1081 ctgtgaccct gcgagttgag cggctgtgac gctgcgagtc gaccggccgc tgcgtgtggt
     1141 cctggccgag gacagcgtgc tgttgcggga cggcctggtc gggctgctcg gccgctgcgg
     1201 acacgaggtc gtcgcggccg tcggggacgc cgaggcgctg gtcacggccg tcggggagca
     1261 cgaccccgac gtggtcgtga cggacgtgcg gatgccgccc ggcttccagg acgagggcct
     1321 gcacgctgcc gtgcgcctgc gcggggagcg gcccgcgctg cccgtcctgg tcctcagcca
     1381 gtacgtgcag cgccgctacg ccgccgaact gctggactcc ggtgacggca cgggcgtcgg
     1441 ctacctgctc aaggaccgtg tcggccaggt cgaggagttc atcgaggcgc tcggcgaggt
     1501 cgccgacggc ggcacggtcg tcgaccccga ggtcgtacgg cagttgctgc gtcgccgccg
     1561 cgacccgctg gagcggctca ccccgcgcga gcgggaggtg ctggcgctga tcgcggaggg
     1621 caggtccaac agctccatcg cccgcgaact ggtcgtgtcc gaagcggccg tgggcaagca
     1681 cgtctccggc atcctcacca agctggacct gccgccggcg gacgggacgc accgccgggt
     1741 gctggccgtg ctggcgtatc tgcgggcctg aggccggccc caacgtgccg cgcccgccca
     1801 cgcgttgtgg aaaaaccacc gagttggttt cattgcgtcg cccatcagag ccgtgcaggg
     1861 gagccacggg tgaccaaaca ggaccgggcc gtccggaccc gtctcgcgct gatccggtcg
     1921 gccgccgagc acttcgaggc acgcggatac gtccgggcca gcctggcgga gatcagcgcg
     1981 ggagccggag tcagcgccgg cgcgctgcac ttccacttcg tgaacaaggc cgccgtggcc
     2041 gaggccgtcg agcacgtcgc cgcccgcgcc ctgcgccgtg ccgcggcccg gggccgcggc
     2101 ggcgacgggt gcgcgttgca gcgcctggtg gacgtcaccc accacgtcgg ccggctgctg
     2161 cgcgccgacg tcgtggtgcg cgcggggctg cggctcaacg ccgaggcggt cgccgggcgg
     2221 gtgcgtgacc tgcgccggga gtggcgggag tgcgtgcatg aactgctggc cgaggcggag
     2281 cggaagggcg aactcgccgc cggggtgccg ccgcaccgcg gcatcgccgt cgtcctcgcc
     2341 gccacgaccg gcatcgaggt gctgtcccgg gacgaccacg gctggctcgg gcggcactcg
     2401 ctgaccgacc tgtggcacct gctcctgccg tgcgtggccg caccgcacgt ggccgtcgcc
     2461 ctggacccgg cggggagcgg gcggcacctc gtggaaccgg acgccgacgc ggacacggac
     2521 gcgccgcagg gggacaccaa ccgggcaggg ctcgcgctgc ggtagcggcg tcgcggcccc
     2581 gcccggccgc cccgccacct cgccgctgcg ccccgctccc cgcccctcac cgacacgccc
     2641 acagcgttaa gccatgggca aaacaaaccg gttgccaagt tttctcgtcg ctcccatcgg
     2701 acgatggttc cccctgcctc tggttcaagg agcgatgtgt catggcacag caggcctgcc
     2761 ccttcctgac gatcgagccg tccggccagg acctgtacgg cgagatatcc cggatccgcg
     2821 accagggccc ggccgtcgag atcgaactcc ccggcggcgt acgggcgtgg tggatcaacg
     2881 gcctggagct gaacaagcgg ctcctggccg gtcccgagac gagcaaggac gccttccagc
     2941 actggccggc ctggatcaac ggggacatct cccgcacctg gccgctcgcg atctgggtct
     3001 cggtgcgcaa catggtcacc gcctacggat ccgaccacag ccggctgcgc aagccgatgg
     3061 ccgccgcctt caccaagcgc cgcgtcgacg cgctgctccc ccgcgtccag gagatcgtcg
     3121 accgggcgct ggacgacctg gagcggatcc ccgccggcga agtcgtcgac ctgcgggcgg
     3181 cgttcgcggc gccggtgccg cacgaggtgg tgtgcgaact cttcggcgta ccgcgcggcg
     3241 aggacggccc gcgcagggcc ctctaccgga tcatcgacag cttcttcgac acggcgatat
     3301 ccctggagga cgcccaggcc aacgccgtcg acctgtacgg cacgctgacc gcgttcctcc
     3361 aggacaagcg cgagcacccg gccgacgacc tgacgaccgc cctcatcgcc gcccgcgacg
     3421 aagggagcct cagcgaacag gagttgatgg acaacctgat cctgctgctc accgcgggtt
     3481 tcgagacgac cgtcaacctc atcgacaaca cggtgcacag cctgctggcc caccccgacc
     3541 agctcgaact cgtccgctcc gggcgggtga cctgggagga cgccatcgag gagtcgctgc
     3601 gcttcgaggc acccggcgcc atgtcgggcc tgcgctacgc cgtgcaggac atcgagatcg
     3661 agccggggct gacgatcccg aagggcgacc cgctcgtggt gtccttcgcc ggcgcgggac
     3721 gcgaccccga gcggcacggc ccggacgccg agcggttcga cgtcacccgc gccaccagcc
     3781 gcgaccacgt gtccttcggc cacggcgtgc accactgcct gggccggcca ctggccatgg
     3841 ccgaggccac ggcggccctg acgtccctct tcgaccgttt cccccggctg gccctggccg
     3901 acccggcccg gccgccgaag cggctgcggt ccatcatctc gacggggcac caggaactgc
     3961 ccgtgctgct gcacggccgc aacccgggcc cggacctggg tccgcgtgcg gaggaggccg
     4021 gagcgatcag gaagctgagc gagctgcgag gaacgagcgg taccaaggtg ccgcgcgcgt
     4081 gaacccggcg gcgaaaccgt cgccgggcga gcagtcgagg accttccaga aggcgtcgtc
     4141 cacgaaccag tggtcgaccg tgagcatgcc caggtgatgc agggcgaacg gtgtcccggc
     4201 ggcccggtcc agagcggtgg cgacatccac cgccgcaccg ccgccgggct cctccacctg
     4261 cgcgcacacc gcaccgagca gctccgccgc cccgaccggc tcggggtggt tgacgtggtg
     4321 caccccgccg tcgagcgccg gcgacagggc cgcggccacc accgcacgac ccagggtgcc
     4381 gacgtcgatc atcgactgga gtgccgcgca gccggtcagg gtcgccgaca gctcgcgcag
     4441 cagccgcacc agtccgggga cgacccagcg gtcgccctcg ccgtacacga ggtgcgggcg
     4501 cagcaccagg ccgccggcgt cgaggacgtg ccgttcggcg gcggcccggg tgcggctggt
     4561 ggccgacgcg ggcgcgaccg gcacctcccc ggggcgtacg ccgcggaagg ggccccggcc
     4621 gtacaccgcg gccgtgctca cgtacacgat ccggctcact ccggcgcgga cggcctcctc
     4681 gaccagggcg cgggtgccca ggtcgttgac ggcctcgacg gtcccggcgt cgccgtcgat
     4741 ccgcgtggcg cagtgcacca ggacgtcggt gtccgcgcag acaccgcgca gggacggggg
     4801 gttgaggaga tcgccgtgga ccacttcgcc gtggccgggt tcgccgcgga aggggtcgcc
     4861 ctggaccggt tcgccggggg ccgctccctg gtgcgtccgg cgggacaagt gtcgtacccg
     4921 gacgtccggt cgcccctgtg cgacggccgc cacccggctg ccgacgaagc cgcttccgcc
     4981 cgtgatcaga acgttgaccg tcacgacagg gaccgtaccc gggccggctg cgcgcaggtc
     5041 agcgtggcgc tgaagacgga cttgccctcc tgccgtccct cgacccggac ggtgacctgc
     5101 cccggctcct cgtcgaggac ctgcgtctgg atccagcacg gggtgtccag ctcggcgtac
     5161 cgggcgaagg tggccgtcat cgcgcggggc aggaaggggt gccggccgga ggcggcggtc
     5221 gcggcctggc gggccgcctc gaacaggacc atgccgggca cgtggtcgtt gggccggggg
     5281 aagagcaccg gatggccggt gtcgacgcgc agccgccaga cgcccggccg gccggcgggt
     5341 gcgaggacga cgtcctcggc gcgagcccgg cccgcgacct ccggggcgat gcccggcggc
     5401 agcgggaggt gagtgaccgg ggcggtcagc cgctgtgccc gcagacggcg gtaggcgagc
     5461 ggggaggtgc aggcggtgct gcccgtgccg cgggccacga ggcgtcccgc ccggcggaac
     5521 tccatggtgg tgcgcatgct gtgcaggccc cggccccggc ggcggatctc cgagcacacg
     5581 acgtcgatct cgaccggctc ggcggcgtcc gacagcagga gcgcggacgg gtcggtgaag
     5641 acggtcaggt cgtacatgac gaaatgggtg tcgtcggggg cgccgaactc ggcgtgcgcg
     5701 agcaccatcg aggcctgccg caacgtttcg cccacgatca tcggatcctg gtggcggtcg
     5761 tccacggggt ggaagaaggt gtggacggca ggccagtggg cggtgaagcg gaagcgggtc
     5821 tcggagattc ggcaccaccg ggtggggaag acgtccgtgt cgacggtgcg gtgggccagc
     5881 tctttggtga ccggggtgga gtcggggggt tctatgtcgg ggggttcgat gggatcgatg
     5941 accacggggt atggcgcgtt ctcgacggcc gcaggcgttt cgtttgccgg accggcccag
     6001 tgtccggtct gatcgtccaa gggtgcgctt aaaggtcctg actgctgcat gagaaccccc
     6061 aggatcggct gcctggctga ggtcggcgtt tgactaagat acggactagc cggttttttt
     6121 caaagggtgg gccacaccgc tggaaacggc ctctcgcgcc cccgctgcac agcggtttca
     6181 cagggatcga cggagatcag gaggcatgcg atggcgcgac aggagcgcgc gatccgcacc
     6241 cggcggacca tcctggaggc ggccgcggcc gtcttcgacg aacgtggcta cacctcggcg
     6301 accatcgggg agatcctgga ccgggccggg gtcaccaagg gcgcgctgta cttccatttc
     6361 ggctccaagg aggagctcgc ggtgggggtg ttcgaggagc agctctcgat cgcgctcccg
     6421 ccgcagtcca gcaaactcca ggaactcgtc gactccgggc tggtgctggc ccgccggctc
     6481 cggtccgaac cgctggtgcg cgccagcgtg ggactcgccc tcgaccaggg ggccatggac
     6541 ctcgaccgca ccatggcctt cggcatgtgg ttcgaccaga acgtgcagcg gctcgccgag
     6601 gcgaaggccc agggcgaact gctgccgcac gtcgacgtgg cggagacggc ggagctgctg
     6661 gtcggcagct tctcgggggt gcagctgctg tcccagctgc gctgccagcg gcaggatctg
     6721 gagcgccgtg tcgtcgtgct gttcgaacac ttcctgccga gcatcgccgt ccccgcggtc
     6781 ctggcccgtc tcgacatctc ggcggagcgg gcggagcggg tgctggcgga ggggcgggaa
     6841 caggtgggtg ccgtgccggc gcaggcctcg ccgggggcgg tgcgggcttc ctcggcgaca
     6901 taggggccgg tgacggcaga gggcggcggg cagggcggaa ccggcctcga cgtcctcggg
     6961 tcggctcccg cacgagttgt ccacagtcgt ggagttttcc ccagggtgtg acgcgtttgg
     7021 gccgccggtt gtacggtcgg catgagttgc tgttcgtgtg cgtgcggggg aaggcggtcg
     7081 gtatgaccag ggctggagca gagggcggga ccggggcgca ggacgggacg aggcgtcggc
     7141 tgccccgggt gcgaggcttc gccgaatggc cgcccgaggg ctcacccaag gacgagggca
     7201 aggccctgcg caagcggatc ccccgcggcg cgcacgccac gctcgacctg cacgcgtccc
     7261 ggcccgacgc ggtgagcgcg gtcgaggagt cgaaccgcgg caggctcccc gagctcaccg
     7321 cgatccgggt cggccgcatg gccgccacac cgttcgcctt cctgcgcggc gcggcgggcc
     7381 tcatggcgta cgacctggcg cacaccccca tgacccggat acgggcgcag atctgcggcg
     7441 acgcgcacgc ggccaacttc ggcctgtacg gcgacccgcg tggcggactc gtcatcgatc
     7501 tgaacgactt cgacgagacg gtgcggggcc cctgggagtg ggacctcaag cgcctcgtgg
     7561 cctccctggt gctcgcgggc cgggaggccg gtgccgacga ggaccggtgc cgcaaggcgg
     7621 cccaggacgc ggtgggcgcc taccgccgca ccatgcggct gctggcgaag ctctcggtgc
     7681 tggacgcgtg gaacgccatc gcggacgagg aactcgtctc ccacacggac gcccacgacc
     7741 tggtcggcac gctggagcgg atctccgaga aggcccgccg caacaccagc ggccgcttcg
     7801 cggccaagtc gacggaggcc accgaggacg gcgggcgccg cttcgtcgac gccccgccgg
     7861 tgctgcggcg ggtcccggac gcggaggccg cggcggtggc ggcgtccctg gaggagtacg
     7921 tcggcacgct gtccgaggac cgcctgccgc tgctcgcccg gcacgcggtg catgacgtgg
     7981 cgttccgggt cgtgggcacc ggcagcgtcg gcacccggtc ctacgtcgtc ctgctgctgg
     8041 accaccgggg tgagccgctg gtgctccagg tgaaggaggc gcggccgtcg gcactggtgc
     8101 cgcatctggt gacggccggt ttcgaagcgc cgcaggccga gcacgcgggc cggcgggtcg
     8161 tgctcggcca gaagcggatg caggtcgtca gcgacatact gctcggctgg acgacggtcg
     8221 acggacgccc cttccaggtc cgccagttcc gcaaccgcaa gggcagcgtc gacccggccg
     8281 ctctcgccgc cgaccagatg gacgactacg gccgcatgac cggcgcgttg ctggcccgcg
     8341 cccactccca cagcgtcgat ccgcggctcg tcgcggggta ctgcgggaag agcgatgagc
     8401 tggacgaggc gatggcgggg ttcgccttgg cctacgcgga tcggaccgag gcggaccatt
     8461 ccgacctggt cacggcggtc cgggagggtc ggatcgcggc ggagatgggt gtctgagcct
     8521 gctgcgggca tcagccgcgg gcggcgcccc gctgcgccgg ggtcgcgcaa cgtgcgggct
     8581 gcgacggggc cgggcgcgcc gggtggcagg agcacgggca ccggcactca cgcgaccgtg
     8641 acctaggctg gtcgggtgac gaccccggaa gctgagcagg atggtggcga cgccgcccgg
     8701 cccgaggcac gcctggagcg cgccgtacgg gccgccgagc aggcgctgat cgagtacgag
     8761 atcgcggtgg agaccttccg cgtcgagatc gagaacttct cccgcctgca cgaacagaag
     8821 ctcggcccgc tctacgcccg gctggaggag ttggacgccc ggatcctcga ggcccgggcg
     8881 gcccgcagcg gcgaccccga cgaccggcgc cgggcggaag aggcccgggc ccgcctcgca
     8941 ccgatccccg gcgtcgagga gctgctgcac ggctggatgg acgacagcgg cctgttcccg
     9001 gagtccgtgg cgatgctcac ggaccaggcg gtccggccac cgcggcgggt ccgccccagc
     9061 gaggaggccc gcaagctcta ccgcgacctc gcccgcaagg cccaccccga cctggcccag
     9121 gaggagaagg aacgcgcgcg gcgcgaggag ttcatcaccc gggtgaacgc cgcctacgcc
     9181 cggggcgacg aggcggagct gcgcgagctc gccgaggagt gggccgcggg gcccgagctg
     9241 aagtggggcc cgagccgcgc cgaggagctc tacgcccggc tcgaatggct cgcccagcgc
     9301 aaggagctgc tcgccctgct cgccaaggag ctggaggaga gcgccatagg ccacatgctc
     9361 cagctggccc cggacgaccc ggacggtctc ctggacgaga tcgggcagca gctgcgcacc
     9421 caggtcaccg agcgcgagaa cgagctggcc gggctgctca cggagggctg agccgcgtcc
     9481 cgtccggccc gcgggccggt tcgggtagcg tcgggcgcat gagttttgga gctggtgtgc
     9541 ccacggtcgc ggtcgcggac ctcaaggacg gcgacttcct gctggacgtc cgcgaggacg
     9601 acgaatggaa ggcgggtcac gccgaggggg cgctgcacat ccccctcagt gatttcgtcg
     9661 cccgctacgg cgagctgacc gaggccgccc cgcaggacgg ccgggtccat gtcatctgcc
     9721 gctccggcgg ccgttccgcc caggtcacga tgtacctggc ccagcagggc atcgacgccg
     9781 tgaacgtcga cggcggcatg caggtgtggg aggcggcggg ccgcgccgtg gtgacggacg
     9841 acggtcagcc ggggttcgtg ctgtagcggc ggttcgccgc acccttcagg ccggcgggtg
     9901 ggccgccagc aggtcgccca gggcctcctc gtgtgccgcc gccgggccga gcgacagctc
     9961 caggtgcttg gcccaggcgt ggtagcggtg caggggatag tcgacgtcgg cgccgaaccc
    10021 gccgtgcaga tgctgcgcgg tctgtacgac ccgtcgtacg ccctccgccg cccagatctt
    10081 ggcgacggcg acgtcaccgg tggcgggcag cgcgcccggg gcccccgagg cgagccgcca
    10141 ggcggcctgc cacagggtgg cctccatcgc gcgcaggtcg atgtagcggt cggcggcctg
    10201 cacggcgacg gcctggaagg tggcgatcgg gaagccgaac tgctcccgct cgcccgtgta
    10261 ctccccggtc atccgcagca cccgctctcc cagcccgagc gccagcgcgc aggtgccggt
    10321 ggccagcagg tcccgcagcc actcccacgc gccgtcggcg tcgatcacgt cccgggccgc
    10381 gagccgcgtc gactgaagcc gcagttcgcc gagccgctcg ccgctggtgg agaactgctc
    10441 ggcgaggtcc accccctggt gcccgcgcgg gaccagggcc agcagggtcc ggccggaccc
    10501 cgtgtgcgcg gggacgaccg tgacgtccgc gtcgtaggcc cagggcaccg ctgtctgcac
    10561 tccgtccagc acccaggtgc cgccgtcctg ccgtgcggtc acggcgagct cggccgggtc
    10621 gtggccggtg cggccgtgcg cggcgacggt cagcacgagc tcgccccggc cggccggggc
    10681 cagcagggcc accctggcct cctcgccgcc gtgggcctgt atcaccgcgg cggcagcgct
    10741 gctctccagc agcggcaccc tggccagcac cttcgccgac tcccgcagca ccaggcagag
    10801 ggcgatggcg tccaggcccg ccccgccgta gcgcgcgtcc agcagcaggc tgagcaggtc
    10861 cgcgtcggcg agcctggccc acagggcgcg gtcgcaggag tcggcgacgg cgccccgggt
    10921 gagggccggg ctgggcacgg cgtcc
//
