LOCUS       NZ_GG657757            10579 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces viridochromogenes DSM 40736 supercont1.1, whole genome
            shotgun sequence.
ACCESSION   NZ_GG657757
VERSION     NZ_GG657757.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces viridochromogenes DSM 40736
  ORGANISM  Streptomyces viridochromogenes DSM 40736
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8653262)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Annotation of Streptomyces viridochromogenes strain DSM 40736
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8653262)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
REFERENCE   3  (bases 1 to 8653262)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Arachne v. April 2007
            Genome Coverage                   :: 8x
            Sequencing Technology             :: ABI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000158955.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 10:17:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,837
            CDSs (total)                      :: 7,762
            Genes (coding)                    :: 7,256
            CDSs (with protein)               :: 7,256
            Genes (RNA)                       :: 75
            rRNAs                             :: 6 (5S)
            complete rRNAs                    :: 6 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 506
            CDSs (without protein)            :: 506
            Pseudo Genes (ambiguous residues) :: 0 of 506
            Pseudo Genes (frameshifted)       :: 293 of 506
            Pseudo Genes (incomplete)         :: 267 of 506
            Pseudo Genes (internal stop)      :: 21 of 506
            Pseudo Genes (multiple problems)  :: 72 of 506
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:49:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3109264
            Orig. end                         :: 3119843
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GG657757.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation was added to the scaffolds in August 2010.
FEATURES             Location/Qualifiers
     region          1..10579
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="12"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10579
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10579
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5579](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5579)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(351..366)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            764..1723
                     /locus_tag="SSQG_RS13585"
                     /old_locus_tag="SSQG_02747"
     CDS             764..1723
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672797.1"
                     /locus_tag="SSQG_RS13585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02747"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_003990341.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 6.6e-53, bitscore:
                     177.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRCAVLDDFQKVATEVVDWSPIAGEVEVVSFDTHLDGEDALAT
                     ALADFDIVVTLRERVPFPGSLIARLPRLKLLVASGMRNSVIDYTAAEEHGVTVCGTASS
                     STAPVELTWALLLGLARGLVEESNALRSGGPWQSTVGADLHGRRLGLLGLGKIGSRVAR
                     IGLAFGMHVSAWSQNLTEERTAEFGVELAPSREELLASSDFVSVHLALSDRTRGLLGPA
                     ELALLKPTAYLVNTSRAAIVDQEALLAALHEGRIAGAGVDVFDIEPLPADHPMRTAPRL
                     LATPHLGYVSRANYTTYYGQAVEDIRAYLAGAPVRRLP"
     gene            complement(1839..2117)
                     /locus_tag="SSQG_RS13590"
                     /old_locus_tag="SSQG_02748"
     CDS             complement(1839..2117)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046783.1"
                     /locus_tag="SSQG_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02748"
                     /product="hypothetical protein"
                     /protein_id="WP_003990342.1"
                     /transl_table=11
                     /translation="MLNSRKIAAVAGLLGSFALIGVGAAQATTDGDPGKCVEDGNGQVR
                     CVDLSQYTYTTENGNKVTVVNNSTQDCPTSHSQVSCVSDTVVSGKKA"
     misc_feature    complement(2102..2116)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            complement(2266..2535)
                     /locus_tag="SSQG_RS13595"
                     /old_locus_tag="SSQG_02749"
     CDS             complement(2266..2535)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046792.1"
                     /locus_tag="SSQG_RS13595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02749"
                     /product="hypothetical protein"
                     /protein_id="WP_003990343.1"
                     /transl_table=11
                     /translation="MRKYQKAAVVVAMLGSVSFLGAGVGHAAGGNDEFKLDNKQNQSCE
                     QNDSREGLINIDDVNVNVALLGLANQDNSERESVTCSQTFSLGK"
     misc_feature    complement(2645..2659)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.74"
                     /tool="antismash"
     misc_feature    complement(2646..2660)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.94"
                     /tool="antismash"
     misc_feature    complement(2647..2660)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.89"
                     /tool="antismash"
     misc_feature    complement(2648..2661)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.61"
                     /tool="antismash"
     gene            complement(2692..2970)
                     /locus_tag="SSQG_RS13600"
                     /old_locus_tag="SSQG_02750"
     CDS             complement(2692..2970)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046783.1"
                     /locus_tag="SSQG_RS13600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02750"
                     /product="hypothetical protein"
                     /protein_id="WP_039932629.1"
                     /transl_table=11
                     /translation="MFNSKKIAAVAGFLGSVALIGAGAVQASAHGGPGACVEDGKGQVR
                     CVQTSEYQVATDKGGNVTVVNDSTQVCPAAHSQVSCVDTVVAPTTRG"
     gene            complement(3059..3337)
                     /locus_tag="SSQG_RS13605"
                     /old_locus_tag="SSQG_02751"
     CDS             complement(3059..3337)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527569.1"
                     /locus_tag="SSQG_RS13605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02751"
                     /product="hypothetical protein"
                     /protein_id="WP_039932633.1"
                     /transl_table=11
                     /translation="MRKYQKAAVVVAMLGSVSFLGAGVGHAAGGDDKFKLDNTQNQSCS
                     QDDSTQGLVNVDDVNVNVAALLGLANQDNSEKESLTCSQAFSLRGGH"
     misc_feature    complement(3449..3462)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.58"
                     /tool="antismash"
     gene            3774..4070
                     /locus_tag="SSQG_RS13610"
                     /old_locus_tag="SSQG_02752"
     CDS             3774..4070
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325458.1"
                     /locus_tag="SSQG_RS13610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02752"
                     /product="chaplin"
                     /protein_id="WP_039932635.1"
                     /transl_table=11
                     /translation="MSRIAKVGAVALGTGAVVLSGAGLAAADAGAKGAAIGSPGVLSGN
                     VVQVPVHVPINVCGNTVNIVGLLNPAVGNTCKNEGHNKKKDDKKSGSKSGHRH"
     gene            complement(4151..5017)
                     /locus_tag="SSQG_RS13615"
                     /old_locus_tag="SSQG_02753"
     CDS             complement(4151..5017)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="SSQG_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02753"
                     /product="tyrosinase family protein"
                     /protein_id="WP_003990347.1"
                     /transl_table=11
                     /translation="MAYVRKDAATLTRAERRRFVKALLEVKRRGEYDEFVRMHIEYFSV
                     DGEHGLRAAHMAPSFLPWHRRFLLDLERALRRVDSSVTLPYWDWTRDRTPTSAPWTADL
                     LGGDGRRLDHQVTTGPFAHREGHWTIKVNVTDRTFLTRDLGRRGDPIALPTKSELEWAL
                     KDPVYDVSPWDSTVTRGFRNKLEGWSSRGDDTSWRNHNRVHGWVGGDMLGGASVNDPVF
                     WLHHAFIDLQWYRWQRRHRGAGYLPATPPRQSDRQHGRIVARRQKLPPWDVTPQELEDV
                     GRIYRYA"
     gene            complement(5001..5579)
                     /locus_tag="SSQG_RS13620"
                     /old_locus_tag="SSQG_02754"
     CDS             complement(5001..5579)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325460.1"
                     /locus_tag="SSQG_RS13620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02754"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_078506847.1"
                     /sec_met_domain="melC (E-value: 4.5e-47, bitscore: 158.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVSGGGGPASGGTPAPARPQAAGSSPREAGGTRRETGNTRREAV
                     SRRQETGSTRREVTRGLRACALAAALAAPVAAAVLPQRSGPGATPTRTTFAQTYRGRRI
                     GAVWTPPLGPDEEGRWHVTVDGRPLHLMRRADGTWLSMVDHYCSYRSPLEAARAAVDQL
                     GPGQRLRDPAAGQEGAEHVHMGDRRGVRT"
     gene            complement(5777..5899)
                     /locus_tag="SSQG_RS43445"
     CDS             complement(5777..5899)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSQG_RS43445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_276327127.1"
                     /transl_table=11
                     /translation="MSTRIPFDVSAQGKESLVSTAKNAASVVNDVKPMHGNLWF"
     misc_feature    6533..6546
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.7"
                     /tool="antismash"
     gene            complement(6660..7346)
                     /locus_tag="SSQG_RS13630"
                     /old_locus_tag="SSQG_02756"
     CDS             complement(6660..7346)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSQG_RS13630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SSQG_02756"
                     /product="hypothetical protein"
                     /protein_id="WP_052310275.1"
                     /transl_table=11
                     /translation="MPALPARRIASSALCAALLVGIAGPVAMAADSVGGQGHVAPEARL
                     PGADARLVQIGRLHWGDLTPVADLLNAVLRDGNGRLSATEARKLGDAAKAAVARAAARN
                     TENPDESTVVLLPAPVLPAVMPVAPEPRAADPVGDLLELVLGAVDGLLETITSGVGGVL
                     PTVDELLGGVDDLLAALVGSDLLPAEQSTSATSSSAPADTSALLTPEAVTYPDVPLLTP
                     ALPPAP"
     misc_feature    7344..7359
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.26"
                     /tool="antismash"
     gene            7736..8824
                     /locus_tag="SSQG_RS13635"
                     /old_locus_tag="SSQG_02757"
     CDS             7736..8824
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056483.1"
                     /locus_tag="SSQG_RS13635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02757"
                     /product="hypothetical protein"
                     /protein_id="WP_003990351.1"
                     /transl_table=11
                     /translation="MRHSLGPLFRRATVGVLALAAVWAAGGSPAAAPAAAPSPEAESLV
                     FGERYRALQHGSIVRAANASITCRATHRPACPDAQAGGSGANGDFDMFYVDVDRDPNTY
                     NSSRGEVRLPSGARVSYARLYWGGNLRVGEQKPAEDNGRVLVAEPGGEYKELIADTVVG
                     HRVLDGMDAFQASADVTRLVREGGPGLYTVAQINIAMGRSTAGSWGGWTLVVAYEHPEE
                     PLRHLSLWDGFAPLNSGGGQTIQLTNLGWAAGAGGRAGLVAYNGDRGSGGDTFTVTTGQ
                     SENALSNAANPQNDVLNSTISEPGADAARVPAYTNTLGYDSDVFDLGRSLERAGDQATF
                     RIRSQQDAAWAGVLFAAVDARR"
     gene            8875..10149
                     /locus_tag="SSQG_RS13640"
                     /old_locus_tag="SSQG_02758"
     CDS             8875..10149
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046802.1"
                     /locus_tag="SSQG_RS13640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSQG_02758"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_003990352.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.3e-33,
                     bitscore: 112.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPSSTAPLPRVLHLTQPVDGGVARVVTDLVRAQLSDGLDVTVAC
                     PDSALTTKLRTLGARVRHWHATRSPGTSLLREVRHLAQVIDEVRPDLVHAHSAKAGLAG
                     RLAVRGRIPTVFQPHAWSFEAVGGGTAALALMWERWGARWASRVLCVSEAERATGMGAR
                     ITGRWTVVPNGIDPERFHPAAAGTVRAGLAPLAGIHPAAPLAVCVGRLCRQKGQDVLLR
                     AWESVVQRVPDARLVLVGDGPDLDRLREGAPPSVVFTGAVADASPWYQAADLVILPSRW
                     EGMALAPLEAMACGRPVVVTDVDGARESLPPAITSRCLVPPENPAALAGAVTELLVDPL
                     LRETLGNQGRRHVLSTHDVRHTAEAVSDVYRDLLGPWTAATPGVIPGAIPGAEHGQPLD
                     TGRGAETNRTPQRVEPTEYRESIHS"
ORIGIN
        1 aggtgcgcag ggactcggtg tcggggccga cctggtcgtc gccgccgaag accgtggcgt
       61 gcaggtgccc gtgcgggatg ccgaagccgt cgcgcagcag ctcgtgggcc caacgcaggc
      121 tctgttcatg gccgtagtcg ccgagtgacc acgagccgag catctcgaag accgtcaggt
      181 gggtggagtc gcccacctcg tcgaggtcgg tggtgcgcag gcagcgctgg acgttggtga
      241 ggcgccgtcc ctgcgagtgc ggacggccca tcaggtacgg cgtgagcggg tgcatgccgg
      301 aggtggtgaa gagcaccggg tcggacgggg gtggcaggag tgtgctgccg gtgacgagcc
      361 ggtgtccgcg ctcgcggtag aagtcggtga aggtgcgtac ggtccggtcc gtgttcatca
      421 cggtgttcat ggctgttccc tcgggttcgt gggggcatcc gggtcatcga gtacggagac
      481 cggaaggaac cgcggggaac ggggcgcgga caggggtccg gcggtgatcc ggcggtccgt
      541 ctccggccgc cggggtgagt gtcaggtcag acgtcggcag ccggtgagct ggtcgctcgc
      601 gcggctgcgg tggtggtgtg ggtcatgacc tgcatgggtc gcacgctaac agcgggcggt
      661 gcgggtcgtc gcggggtttt tccgggtgcg ggccagcggc cggaggcgtt gccgtccggc
      721 atagagtcgg tctcccggcc atgggacgtg gagaggaagc gacgtgcggc tgcgctgtgc
      781 tgtgctggac gactttcaga aggtggcgac cgaggtggtc gactggtcgc cgatcgccgg
      841 tgaggtggag gtcgtgtcct tcgacaccca cctggacggc gaggacgccc tggccacggc
      901 gctggcggac ttcgacatcg tggtgaccct gcgcgagcgc gtgcccttcc ccgggtcctt
      961 gatcgcccgc ctgccgcggc tgaaactgct cgtcgcctcc ggcatgcgca actcggtcat
     1021 cgactacacg gccgccgagg agcacggcgt caccgtgtgc ggcacggcaa gctcctccac
     1081 cgcgcccgtg gaactgacct gggccctgct gctcggcctc gcccgcggcc tcgtcgagga
     1141 gagcaacgcc ctgcgctccg gcggcccctg gcagtccacc gtcggcgccg acctgcacgg
     1201 ccgccgcctc gggctgctcg gcctcgggaa gatcggcagc cgtgtcgccc ggatcggcct
     1261 cgccttcggc atgcacgtca gcgcgtggag ccagaacctc accgaggagc gcaccgcgga
     1321 gttcggtgtc gaactcgccc cgtcccggga ggagctcctc gcgagcagcg acttcgtctc
     1381 ggtccatctc gcgctgagcg accgcacccg cgggctgctc ggccccgccg aactcgccct
     1441 cctcaagccg accgcgtacc tggtcaacac ctcgcgcgcg gccatcgtcg accaggaagc
     1501 gctcctcgcc gcgctgcacg agggccggat cgccggcgcc ggcgtcgacg tcttcgacat
     1561 cgagcccctg cccgccgacc acccgatgcg caccgcgccc cgtctcctcg ccacgccgca
     1621 cctcggctac gtctcccggg ccaactacac gacgtactac ggccaggcgg tcgaggacat
     1681 ccgcgcgtac ctcgcgggcg cgcccgtacg acggttgccc tgacgcccgg acacacggac
     1741 ggccgggacc cggtatcggg tcccggccgt tctccgctca agcgggtgga cgcacgcgag
     1801 gggcgacgac gtggacaagg cgcctcgggc tcggggcgtc aggccttctt gccggagacg
     1861 acggtgtcgc tgacgcagga gacctggctg tgcgacgtcg ggcagtcctg cgtcgagttg
     1921 ttgacgacgg tgaccttgtt gccgttctcg gtggtgtacg tgtactggct caagtccacg
     1981 cagcgaacct gaccgttgcc gtcctcgaca cacttgccgg ggtcaccgtc ggtggtggcc
     2041 tgggcggcac cgacaccgat cagggcgaag ctccccagaa gccccgccac cgccgcgatc
     2101 ttcctcgaat tgagcattta ccttttcctt tacggtcgac tccccgccac tggacgacgg
     2161 agtcgttccg gacacgatta ccggcgaaga agccaagagg caggccccgc ggctcggaca
     2221 cctggttcga gccccggggc ctgcctggat cacctggatc ggtgattact tgcccaggga
     2281 gaaggtctgc gagcaggtca cggactcacg ctcgctgttg tcctggttgg ccaggcccag
     2341 cagggcgacg ttgacgttga cgtcgtcgat gttgatgaga ccctcacgcg agtcgttctg
     2401 ctcgcacgac tggttctgct tgttgtcgag cttgaactcg tcgttcccgc ccgcagcgtg
     2461 acccacgccg gcgcccagga agctgacgct gccgagcatg gccacgacga ctgcggcctt
     2521 ctggtacttg cgcattactt ctccgattct cgagtcgaca cagaccgtga tgggctggtc
     2581 accaacagtc gccaacttta tgcgactcgc accgctccca ccggggcgaa acgcccaatt
     2641 ccgtaagttt cttgaaaaga cacgctggag gggcagttca ccgacagggc gtcagcccct
     2701 cgtcgtgggg gccaccacgg tgtcgacgca gctgacctgg ctgtgcgcgg cgggacacac
     2761 ctgcgtggag tcgttgacga cggtgacgtt tccacccttg tcggtggcga cctggtactc
     2821 gctcgtctgg acgcagcgca cctgcccctt gccgtcctcg acgcacgcgc cggggccgcc
     2881 gtgagcggag gcctggacgg cgccggcgcc gatgagagcg acgctcccca ggaaccccgc
     2941 caccgccgcg atcttcttcg agttgaacat ctgcctcttc ctttgccaga agccaggaaa
     3001 caggccccgg ggctcggaca catggttcga gccccggggc ctgctcagat cacgaagatc
     3061 agtgaccgcc gcgcagcgag aacgcctgcg agcaggtcag ggactccttc tcgctgttgt
     3121 cctggttcgc caggcccagc agggcggcaa cgttgacgtt gacatcgtcg acgttgacga
     3181 ggccctgggt cgagtcgtcc tgcgagcaag actggttctg cgtgttgtcg agcttgaact
     3241 tgtcgtcccc gcccgcagcg tgacccacgc cggcgccgag gaagctgacg ctgccgagca
     3301 tggccacgac gaccgcggcc ttctggtact tgcgcattac ttctccgatt tctcgagtcg
     3361 acacagaccg ttatggtccg gtcactgaca gtcgctaaca taagcggcac caggggcttt
     3421 tgccacgcga aacgccccgc agcatggctt tcttgtgaaa gtgcaggcca cagcgctccc
     3481 gcggatgcat cgagtgggtc aagcaggggg cgagcgggcg ccctgttccg ctggcgcaca
     3541 ggcggccgca gccacccgcg gtcgcaggtg gagggccacc ccgcccgttc acgcggcgca
     3601 gaggccgtgc agcgagcagg agaccgcgaa caacacccga atggccgagc ctctgttcaa
     3661 gacgggtgat ctggtgagga tttgtcgtga ctggtccggg gtcctcgcgt tgaaggggca
     3721 gtgcggtcgc gcgtactgct gccgtactta cctagtcagt aagggagaac gtgatgtctc
     3781 gcatcgcgaa ggttggcgct gtcgctctcg gcacgggcgc cgtggtgctc agtggggccg
     3841 gtctcgccgc ggcggacgcg ggtgccaagg gtgccgccat cggctcgccc ggcgtcctgt
     3901 ccggcaacgt ggtccaggtg ccggtccacg tgccgatcaa cgtgtgcggc aacaccgtca
     3961 acatcgtcgg cctgctcaac ccggccgtcg gcaacacctg caagaacgag ggccacaaca
     4021 agaagaagga cgacaagaag agcggctcga agagcggcca ccgccactga cgtccactgt
     4081 ccgactcgag agccccggca cccgatcgcc ggggctcttt ccttcgtcgg cgcccggaat
     4141 ccgtgtcacc tcaggcgtag cggtagatcc ggccgacatc ctccagctcc tgcggtgtca
     4201 cgtcccacgg gggcagcttc tggcgccggg ccacgatccg gccgtgctgc cggtcactct
     4261 ggcggggcgg tgtcgcgggg aggtatccgg cgccgcggtg gcggcgttgc cagcggtacc
     4321 actggaggtc gatgaaggcg tggtgcaacc agaacacggg gtcgttgacg gaggcgccgc
     4381 cgagcatgtc accgccgacc cagccgtgca cccggttgtg gttgcgccac gaggtgtcgt
     4441 cccctcggct gctccagccc tccagcttgt tgcggaaacc gcgcgtgacc gtcgagtccc
     4501 agggcgacac gtcgtagacg ggatccttca gcgcccactc cagttcgctc ttggtgggca
     4561 gtgcgatcgg gtcgccgcgg cgtccgaggt cccgggtgag gaacgtcctg tcggtcacgt
     4621 tcaccttgat ggtccagtgg ccttcccgat gggcgaacgg gcctgtcgtc acctggtggt
     4681 ccaaacggcg cccgtcaccc ccgaggagat cggccgtcca gggcgcggag gtgggtgtgc
     4741 ggtcgcgcgt ccagtcccag tacggcagcg tcaccgagga gtccacccgg cgcagcgcgc
     4801 gctccaggtc gagcaggaac cggcggtgcc agggcaggaa cgagggcgcc atgtgggcgg
     4861 cgcgcagccc gtgttcgccg tccacggaga agtactcgat gtgcatccgc acgaactcgt
     4921 cgtactcgcc ccgccgtttg acctccagca gcgccttgac gaaccggcgc cgttccgccc
     4981 tggtgagcgt ggcggcgtcc ttacgtacgt acgccacgcc ggtcccccat gtgcacgtgc
     5041 tccgcgcctt cctggcccgc ggccgggtcg cgcaggcgct gtccggggcc gagctggtcg
     5101 acggccgcgc gggcggcctc gagcggtgag cggtaggagc agtagtggtc gaccatgctg
     5161 agccaggttc cgtcggcccg gcgcatcagg tgcagcggcc ggccgtccac ggtgacgtgc
     5221 cagcggccct cctcatcggg gccgagcggc ggggtccaca ccgcgccgat gcgacggcct
     5281 cggtaggtct gggcgaaggt ggtgcgggtc ggggtggccc cgggcccgga gcgctgcggc
     5341 aggacggcgg cggccaccgg ggcagccagg gccgcggcga gggcgcaggc gcgcagaccc
     5401 cgcgtcacct cccgccgcgt actgcccgtc tcctgccgcc tactgaccgc ttcccgccgc
     5461 gtgttgcccg tctcccgccg cgtaccaccc gcctcccgtg gtgagctgcc cgccgcttgg
     5521 gggcgcgccg gggccggtgt cccgccgctc gccggtcctc cgcctccgct gacgaccatg
     5581 gtccactcct cgtccggttt ccgctgtcgt agcggtaacc gccggacgtc ccgcgcggtc
     5641 accgccgcgc ggccagacaa gtgatcttca gcgtccgtcc cggcggggag cggggcgcgt
     5701 caccggccgg gcacaaacgg agggccggtc ctcggacttc tcgaggaccg gccctccgta
     5761 gggcgtggtt ccagccctag aaccacaggt tgccgtgcat cggcttgacg tcgttgacca
     5821 cggacgcggc gttcttcgcc gtgctgacca gcgactcctt gccctgggcg ctcacgtcga
     5881 aggggatcct ggtgctcacg ccgccggtga ggtcggtgga cgccaggtca cgggtgccct
     5941 gagcggccgg agcgggctca ggagcggaag ccggctgagc ggccggagcc ggctgcggag
     6001 cgggcggagc aacgggagcg ctctgcacag ccggagcagc ctgaggagcc ggggcggcct
     6061 gaggagccgg agcagcctga ggagccggag cggcctgagg agccggggcg gcctgagggg
     6121 caggagcggc ctgaggggca ggagcggcct gaggagccgg agcggcctga ggagccggag
     6181 cggactgggc aaccggggcg ctctgcacag ccggagcgct ctgagcggcg ggcgcgctct
     6241 gcaccggagc ggcctgagcg gccggggcac tctgggcggc cggggcgctc tgcacatccg
     6301 ggacgctctg agcggcggga gcgctcgggg cgaccatggc gtcgtgggcg aacgccggtg
     6361 tggcggaacc agcggcgatc aaggacccgg caaagacggc ggcagccttc agagacttca
     6421 tcgtgttcct ttcttcggca acgcacgtcg ccggaggggt ttctgtcgcc gtgcctaacg
     6481 agctctggcc tgggcggaaa ccgagatccc gaagattgcc gatacctcat acgagatcta
     6541 ttaaaagacc ggcgccgagg gcggaaagga accgggggaa aacgtgaagc cggacggggg
     6601 acacgacagt cgtggtgccg ctccgagagg gccggcacca cgactggacg agctcgggat
     6661 caaggggccg gcgggagcgc cggcgtcagc agcgggacat cagggtaggt gacggcctcg
     6721 ggagtcaaga gcgcggacgt gtcggccggg gcgctcgacg acgtcgcgga agtggactgc
     6781 tccgcgggca acaggtcgct tccgaccagc gcggcgagca ggtcgtccac accgcccagc
     6841 agctcgtcga ccgtgggaag gacaccgccg acgccggagg tgatcgtctc caggaggccg
     6901 tcgacagcgc ccagcacgag ttccagcagg tcgcccacgg ggtcggcggc gcgcggctcg
     6961 ggcgcgacgg gcatcacggc gggcagcacg ggggccggca gcagtacgac cgtcgactcg
     7021 tccgggttct cggtgttccg ggcggccgcc cgggccacgg cggccttggc ggcgtctccc
     7081 agcttccggg cctcggtcgc ggacagtcgg ccgttgccgt cccggagtac ggcgttgagc
     7141 aggtcggcca ccggggtgag atcgccccag tggagtcttc cgatctgtac gagacgcgcg
     7201 tccgcgccgg ggagccgggc ctcgggcgcc acatggccct gcccgccgac cgagtcggcc
     7261 gccatggcga cggggccggc gatcccgacc agaagggcgg cgcagagtgc gctggaggcg
     7321 atgcgccgtg cgggcagagc aggcatgaga attcctttcg acggcgttgg atcttgagcc
     7381 caccgtgaaa gcgcccgggt cttcccgcaa ctgttcatag gcttttcggg attacgtgat
     7441 tccccctttt gcgcgtccat cctgatcaga cggtgtgtca ggaaacctcc ccccggcccc
     7501 tgccggagca acacaccggc cttccccgct cggggcaccg gggccgacgg ccgcgcatca
     7561 gtcaacacac gcggtttcac tattccgaca cacttgtcag acttcaccga atttcttcga
     7621 ctatgtccga ttcatgacta gagttgcgaa ccgcccgacg ccctccccag cgcggacaca
     7681 tcgctctcgt ggcgctgctg ccacggccac ctgttccgaa aggcaacaaa cggtcatgcg
     7741 tcattccctg ggcccgctgt tccgccgcgc gaccgtgggc gtcctcgccc ttgccgccgt
     7801 gtgggcagcg ggcggttctc cggcggccgc accggccgcc gccccctcac cggaggccga
     7861 gagcctcgtc ttcggcgagc ggtaccgcgc gctgcagcac ggcagcatcg tacgcgcggc
     7921 caacgcctcg atcacctgcc gcgcgaccca tcggccggcg tgtccggacg cgcaggcggg
     7981 cggatccggt gcgaacggcg acttcgacat gttctacgtc gacgtcgacc gcgatcccaa
     8041 cacctacaac tcctcccgcg gggaggtccg cctgcccagc ggcgcccggg tgtcgtacgc
     8101 gcgcctctac tggggcggca acctgcgcgt cggcgaacag aagccggcgg aggacaacgg
     8161 gcgcgtgctg gtcgccgaac ccggcggcga gtacaaggaa ctgatcgccg acacggtggt
     8221 cggacaccgc gtgctggacg gcatggacgc cttccaggcc tcggcggacg tgacacggct
     8281 ggtgcgggaa ggcggcccgg gcctgtacac cgtggcccag atcaacatcg ccatgggccg
     8341 atcgacggcc gggtcgtggg gcggctggac gctcgtggtc gcctacgagc accccgagga
     8401 gccgctgcgg cacctctcgc tctgggacgg cttcgccccc ctgaactccg gtgggggaca
     8461 gacgatccag ctgaccaacc tgggctgggc cgccggcgcg ggaggccgcg cggggctggt
     8521 ggcgtacaac ggcgaccggg gaagcggcgg cgacacgttc accgtgacga ccggtcagtc
     8581 cgagaacgcc ctcagcaacg cggccaaccc ccagaacgac gtcctcaact ccaccatcag
     8641 cgagcccggg gcggatgcgg cacgggtccc cgcgtacacc aacaccctcg gctacgactc
     8701 cgacgtgttc gacctcggga gaagcctgga gcgcgccggc gaccaggcga ccttccggat
     8761 ccggtcccag caggacgcgg catgggccgg cgtgctcttc gccgccgtcg acgcacggcg
     8821 gtgactccga cgccgtccgc cccgaacgcc atcgcgagcg aggaatccgc gcacatgcat
     8881 ccgtcatcga ccgcccctct ccccagagtc ctgcacctca cccaaccggt ggacggcggc
     8941 gtcgcgcgcg tcgtgacgga cctggtccgg gcccagctgt cggacggcct ggacgtcacc
     9001 gtggcctgcc ccgacagcgc gctcaccacg aaactgcgca cgctcggcgc gcgcgtacgg
     9061 cactggcacg cgacacggtc gccggggacg tcgctgctcc gggaggtacg gcacctggca
     9121 caggtgatcg acgaggtacg tcccgatctg gtgcacgccc acagcgcgaa ggccggactc
     9181 gccggacggc tcgcggtgcg cgggcggatc ccgacggtct tccagccgca cgcctggtcg
     9241 ttcgaggcgg tcggcggcgg caccgcggcc ctggcgctga tgtgggaacg ctggggggcg
     9301 cggtgggcct cacgcgtgct gtgtgtgagt gaggccgagc gcgcgaccgg catgggcgcc
     9361 aggatcaccg gccggtggac cgtcgtcccc aacggcatcg acccggagcg cttccacccg
     9421 gccgccgccg gcaccgtacg ggccgggctc gcgccgctcg ccggcatcca cccggcggca
     9481 ccgctcgcgg tgtgcgtggg gcggctgtgc cggcagaagg ggcaggacgt cctgctgcgg
     9541 gcgtgggaat ccgtcgtgca gcgggtgccc gacgcccgcc tcgtcctggt cggtgacggg
     9601 cccgacctcg accggctgcg cgaaggcgcc ccgccttccg tggtgttcac gggagccgtc
     9661 gccgacgcct ccccctggta ccaggccgcc gacctcgtca tcctgccgtc ccgctgggag
     9721 ggcatggccc tcgcgccgct ggaggcgatg gcctgcgggc ggcccgtggt ggtcacggac
     9781 gtcgacggcg cccgcgagag cctgccgccc gccatcactt cccggtgcct ggtcccgccg
     9841 gagaacccgg cggcactggc cggggccgtc accgagttgc tggtcgaccc gctgctgcgc
     9901 gagacgctcg gcaaccaggg ccgccggcac gtgctgtcca cccacgacgt gcggcacacc
     9961 gccgaagccg tctcggacgt ctaccgcgac ctgctcggcc cgtggaccgc cgccaccccc
    10021 ggcgtcattc ccggcgccat tcccggcgct gagcacggtc agccgctcga caccggacgt
    10081 ggcgccgaga cgaaccggac accgcagcgc gtcgagccca ccgagtacag ggagtccatc
    10141 cactcgtgac cgccgaacgc accgtgccct cccccggcgt acagccgcgg gagcacggat
    10201 cctcaccagt cacggtcatg ccgccgcgtg gcaccgccac cggcccccgg ctgtccgccc
    10261 cgcggccccc ggcccggccc gcctcacccg tccccctgct cgtcgcggac ggcgtcgccg
    10321 ccctggcggg cgtgccggtg ctcaccgaga cccagcgcca tccactcctg gtcaccctgc
    10381 tgatcgtcgc cgcgctgctg ccgcgccggc gcgacgggcg ggcgccggta ccggggctgc
    10441 tggaggaact gcccgccgtg tgcgggcgga tcgcggtgac ctggctggcc ctcgcggcgc
    10501 tgctggcggc gtaccggccg gagcacgcgc tgtccctcgg taccgtgctg acgggcctcg
    10561 ctctgcatgc gacggcctg
//
