LOCUS       NZ_GG657754            10225 bp    DNA     linear   CON 01-MAY-2024
DEFINITION  Streptomyces himastatinicus ATCC 53653 supercont1.1, whole genome
            shotgun sequence.
ACCESSION   NZ_GG657754
VERSION     NZ_GG657754.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces himastatinicus ATCC 53653
  ORGANISM  Streptomyces himastatinicus ATCC 53653
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
REFERENCE   1  (bases 1 to 10901646)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Annotation of Streptomyces hygroscopicus strain ATCC 53653
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10901646)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
REFERENCE   3  (bases 1 to 10901646)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Arachne v. April 2007
            Genome Coverage                   :: 6x
            Sequencing Technology             :: ABI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000158915.1-RS_2024_05_01
            Annotation Date                   :: 05/01/2024 03:02:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,680
            CDSs (total)                      :: 9,608
            Genes (coding)                    :: 8,720
            CDSs (with protein)               :: 8,720
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 1 (5S, 16S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 888
            CDSs (without protein)            :: 888
            Pseudo Genes (ambiguous residues) :: 0 of 888
            Pseudo Genes (frameshifted)       :: 423 of 888
            Pseudo Genes (incomplete)         :: 530 of 888
            Pseudo Genes (internal stop)      :: 36 of 888
            Pseudo Genes (multiple problems)  :: 97 of 888
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:01:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9703453
            Orig. end                         :: 9713678
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GG657754.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation was added to the scaffolds in August 2010.
FEATURES             Location/Qualifiers
     region          1..10225
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="38"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10225
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10225
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5225](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5225
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            367..498
                     /locus_tag="SSOG_RS54415"
     CDS             367..498
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014502.4"
                     /locus_tag="SSOG_RS54415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167542542.1"
                     /transl_table=11
                     /translation="MPGTWSNPTRRLGFKRFVSDANLDCVRMDGDNVRSYRDDIPAP"
     gene            529..810
                     /locus_tag="SSOG_RS41000"
                     /old_locus_tag="SSOG_08127"
     CDS             529..810
                     /EC_number="3.2.1.23"
                     /GO_component="GO:0009341 - beta-galactosidase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004565 - beta-galactosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014502.4"
                     /locus_tag="SSOG_RS41000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_08127"
                     /product="beta-galactosidase"
                     /protein_id="WP_009720211.1"
                     /transl_table=11
                     /translation="MRLGSYQALAHGADSVLYFQWRASRGGHERFHSAMLPHSGTGSRT
                     WQEIEALGTELPRIAEAAGTTAHADIAVLFDWNAWWGLTETNGLPRND"
     gene            768..1076
                     /locus_tag="SSOG_RS52800"
                     /old_locus_tag="SSOG_08128"
     CDS             768..1076
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSOG_RS52800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SSOG_08128"
                     /product="hypothetical protein"
                     /protein_id="WP_009720212.1"
                     /transl_table=11
                     /translation="MGADRDERPAAQRLTVGRGRVVYIGTRLEATALRDTLLDAVSAAG
                     VSPLLDHAPAHLEATRRATETVRVPLTVDGIDLVSGTETDGAVELAPLAVAVVRSER"
     gene            1475..3617
                     /locus_tag="SSOG_RS41010"
                     /old_locus_tag="SSOG_08129"
                     /pseudo=""
     CDS             1475..3617
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645563.1"
                     /locus_tag="SSOG_RS41010"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_08129"
                     /product="FUSC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTWPRSLMDIVRSGLTIERARLEPLAALRAAAGVAIVIGLSLWTA
                     SPSYAASAAFGAFSAGTSTFQRSWRPRKVIALVAGAGLGLSTFVGYLAMSHLALFLLLL
                     AVWAFLAGMAWAAGPTAGIVATTTVAMMLLTITLPTGVMEALEHAAVIAFGGVAQAVLI
                     FLFPIRRWGRHRDALADALAAVADYARRLREDPVAPFDPEPMITARSAAAVTPSQARRR
                     PAALHGPRGLAERIRPALAALADPRVGAPAEGPGRDRARELLDAAADVLDAAARSIRRG
                     APAEVPSATRETLRIDDEDGAEETDEGGAEEPLEGPARRAAVQLSYLLTEVLEIADSSG
                     RGLGPTSGADEAPPLLRPTVFQLVPIVLRAMRRELRGDSPVLRHALRLAAVACLGYVLG
                     SALPLGHGYWAPVTSVMVMRPDFHRTYSRAVARFAGTLVGVALATGAVQLTHPDAYLSG
                     GLAVIAAAPDVSADAHRIRGLAVHLGRVRRPPARDGRRGVAPDRAGPGPAHPAGRGARD
                     ARVRGLPGLGDTADAGPARGLARRERPVRGGGGSRLRRAR"
     gene            complement(3614..4441)
                     /locus_tag="SSOG_RS41015"
                     /old_locus_tag="SSOG_08130"
     CDS             complement(3614..4441)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018851478.1"
                     /locus_tag="SSOG_RS41015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_08130"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_009720214.1"
                     /transl_table=11
                     /translation="MRIGVSTFVTDQGIGPAALGRALEERGFDSLFIAEHSHIPVERRS
                     PYPGGGELPEIYYRTLDPFVTLSVIAGVTTRLLLGTGVALVAQRDPIITAQEVASLDVV
                     SGGRAVFGVGVGWNREEMENHGTDPSTRGRLVDERLEAIVQLWTKEKAEYHGEFVNFDP
                     VYQWPKPVQRPHPPVYVGGGEAAFPRIAAHGDAWLANSVPPDGLAPQIERLRQVAGRDV
                     PVTVYAVPDTAEALEGYRRLGVDRVLLYLPTKPEGETLAHLDTMAALAERFRS"
     misc_feature    4748..4764
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    4963..4977
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            5001..5225
                     /locus_tag="SSOG_RS41020"
                     /old_locus_tag="SSOG_08131"
     CDS             5001..5225
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_l"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="SSOG_RS41020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_08131"
                     /product="hypothetical protein"
                     /protein_id="WP_009720215.1"
                     /sec_met_domain="strepbact (E-value: 5.1e-29, bitscore:
                     99.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_l (E-value: 8.2e-05, bitscore:
                     21.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNAPKVATQEISDAELDNVAGGLGAVGDALGTVQSVTGPVTGPV
                     TGAVGTVTGTVDGATGLNTSGIVGTVAGL"
     gene            5365..6174
                     /locus_tag="SSOG_RS41025"
                     /old_locus_tag="SSOG_08132"
     CDS             5365..6174
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="SSOG_RS41025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_08132"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_009720216.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSADDIDLPVRYARPQGWLALAVTLVAMAAAAVW
                     AVTGTVGDTLGASGILTHGQGSYVLQSPVRGQVTAVLAKEGSTVRAGAPLVKVRNPGGG
                     ATFVRALAAGRLTTLSVSIGSVLNTGADVASVERVRDSRDPLTATLYVPADRAASVPAG
                     ATVDLDVQSAPSGTYGVLRGHVQAVGRTAQSRKQIGSFLGSAQLGEEFSKQGPPVAVAV
                     RLDRSSATRSGYRWSSPKGPPFALGSMTLASGTIHLADRHPVDWLLP"
     gene            6372..8503
                     /locus_tag="SSOG_RS41030"
                     /pseudo=""
     CDS             6372..8503
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510298.1"
                     /locus_tag="SSOG_RS41030"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /pseudo=""
                     /sec_met_domain="Peptidase_C39 (E-value: 2.6e-35, bitscore:
                     120.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEALECGAASLAMVLAHYGRHVPLEELRIACGVSRDGSRASNVLK
                     AARSYGLRAKGMQMEPEALAEVQAPAILFWEFNHYVVYDGMGRRFGKRGVHINDPDKGR
                     RFVSAEEFGASFTGICLVFEPDASFSRGGRKPGILNALPARLRGTGGTLVASLLASLLL
                     VAVGAAVPALSRTFIDTFIVGGQTSMLPPLFASMAVAVVLTAVLTGVQQANLLRGRIIS
                     STLGSARFLRHLLRLPVTFFAQRSPADLVQRLRSNDTVAETLARDLAAAAVDGIVVVLY
                     ALLLWTYDPQLTLVGVGLALLNVVAMRIVIRLRATRTQKLRADTARLTTTAYTGLQLHR
                     DHEGHRRRERLLPPLGRSARHHAGGTAASRCAERGPGRGGAHPRHPQQRAHPVDRWPAS
                     RRGPSVGRAAGGLPGAWSPASPRPSPG"
ORIGIN
        1 gacgcaccct gaccaaggtt ggccggttcg tgccgaccag ccggacttgc tcgtactgcg
       61 gccatgtgga tggccctaaa cccctccaca tccgggaatg gacttgcccc gcttgcggag
      121 ccctcctcga ccgggacatc aactccgcac gcaacgtgaa aagggccgcc ggactggcgg
      181 tatcagcctg tggagcgccg ataagaccag aactcgttct ggcgcagcgc aacgaagcag
      241 gaagccacgg attccctccc gaaggccgtg cggcgtagcg gcacagcacc gagagagaag
      301 gccagaatcc tcgggccagc ccgaggagca agtcaaacct cctgggacca gatcgacccg
      361 tccgaggtgc cggggacgtg gtccaatccc acccgccgac tgggcttcaa gcggttcgtc
      421 tcggacgcca acctcgactg cgtccgtatg gatggcgaca acgtccgctc ctaccgcgac
      481 gacatcccgg ccccgtagaa ggtcaacaac gtcaagcggc ccggccggat gcggctgggc
      541 tcctaccagg cgctcgccca cggcgccgac agcgtcctgt acttccagtg gcgcgccagc
      601 cgcggcggcc acgagcggtt ccactccgcg atgctgccgc actccggcac cggctcccgc
      661 acctggcagg agatcgaggc actcggcacc gaactgccgc ggatcgccga agccgcgggc
      721 accaccgcac acgccgacat cgccgtgctc ttcgactgga acgcctggtg ggggctgacc
      781 gagacgaacg gcctgccgcg caacgactga cggtcggccg ggggcgcgtc gtctacatcg
      841 gcactcgtct ggaggccacc gcgctgcgcg acaccctgct cgacgccgtg tccgccgcgg
      901 gcgtctcacc gctcctcgac catgccccgg cccatctgga ggcgacccgg cgggccacgg
      961 agaccgtccg cgtccccctc accgtggacg ggatcgacct ggtctccggg acggagacgg
     1021 acggggccgt cgaactggcc ccgctcgccg tcgcggtcgt acggtccgaa cggtaggcgc
     1081 ccacgctgcc cgccgggtac gggcgttccg gcccgtgctg gcgcacccgg acctcggacc
     1141 agtcgccgac ccggaacggg gtggtgctgg tggccaacgc atccggactg ccgccgttcc
     1201 cggcccgctc cgcccgcgcc gcaccctgcc cgcctgaaac accgacgact acgaccgcca
     1261 cgaggcccgc ggctatctgc ggcagaccag gacggcgtcc gcgactccgc gatgcacacc
     1321 accggggaga ccgcgagcga ccgcggtgtg cccgccgacc gggacgagca gttcgccgtc
     1381 ggcgcaaaac cgccgagaag gtgctgcgcc gctggtggcg ggggtggaac ccggctgacg
     1441 tgcgcccccg ccacttccgc ctaggctcgg ctgtgtgacg tggccgcggt cgctgatgga
     1501 catcgtgcgt tccgggctga cgatcgagcg cgcccggctc gaaccgctgg ccgcgctgcg
     1561 ggcggcggcc ggagtggcga tcgtgatcgg gctctcgctg tggaccgcct ccccgtccta
     1621 cgccgcgtcc gccgcgttcg gcgccttctc ggccggtaca tcgacgttcc agcgcagctg
     1681 gcggccgcgc aaggtgatcg cgctggtcgc gggggccggg ctcgggctca gcaccttcgt
     1741 gggctatctc gcgatgtccc atctggcgct cttcctgctg ctgctcgccg tctgggcgtt
     1801 cctcgccggg atggcctggg cggcggggcc gaccgccggg atcgtggcga cgacgaccgt
     1861 cgccatgatg ctgctcacca tcacgctgcc caccggtgtc atggaggccc tggaacacgc
     1921 ggcggtcatc gcgttcggcg gcgtggcgca ggcggtgctg atcttcctgt tcccgatccg
     1981 ccgatggggg aggcaccggg acgcgctggc cgacgccctg gccgcggtgg cggactacgc
     2041 aaggcggctg cgggaggacc cggtggcgcc gttcgacccg gagccgatga tcacggcccg
     2101 gagcgccgcc gccgtcacgc cctcacaggc acgccggcgc cctgccgccc tgcacggccc
     2161 gcgggggctg gccgaacgca tccgtcccgc cctcgccgcc ctcgccgacc cccgggtcgg
     2221 cgcgcccgcc gagggaccgg gccgggaccg ggcgcgggag ctgctcgacg cggccgccga
     2281 cgtcctggac gccgctgccc ggtcgatccg ccgcggcgcc cccgccgagg tgccgtccgc
     2341 gaccagggag accctgcgga tcgacgacga ggacggggcc gaagagaccg acgagggcgg
     2401 cgcggaggag cccctggagg ggcccgcgcg ccgggccgcg gtccagctgt cgtacctgct
     2461 caccgaggtg ctggagatcg ccgacagcag cggcaggggg ctgggcccca cctccggcgc
     2521 ggacgaggcg ccgccactgc tgcggccgac ggtgttccag ctggtgccga tcgtgctgcg
     2581 cgcgatgcgc cgcgagctgc gcggcgactc gcccgtcctc cggcacgccc tgcggctcgc
     2641 cgcggtggcc tgtctcggct atgtgctcgg cagcgcgctt ccgctcggcc acggctactg
     2701 ggccccggtc acctccgtga tggtgatgcg gccggacttc caccgcacct actcccgggc
     2761 cgtggcccgc ttcgcgggca cgctggtggg cgtcgcgctg gccaccggcg cggtgcagct
     2821 gacccacccg gacgcgtatc tgtccggcgg gctggccgtg atcgccgccg cccctgacgt
     2881 atctgctgat gcgcaccgga tacgcggcct cgcagtgcac ctcggccgcg tacgccgtcc
     2941 tcctgctcgg gatgggcggc gaggggtggc accagaccgt gccggaccgg gtcctgctca
     3001 ccctgctggg cggggtgctc gcgatgctcg cgtacgtggc cttcccggcc tgggagacac
     3061 cgcggatgct ggaccggctc gcggactggc tcgccgcgag cggccggtac gcggcggcgg
     3121 tggttcgcgg ctacgccgag cccggtgagc tgcccgccac ggacgtacgg cgcaccctgc
     3181 tcgccgaccg tacggcgcac gccgcgtgga acgaggccct cgaccgggcc aagcgggagc
     3241 ccgtgcgcca ccgggggctg acccgggcgc aggcggagga ggcgcaggcg gcgctggagg
     3301 cgttcgggca ggcggcgatg ttgctggaga cccatctgcc gcagcgtggc gcacggccgg
     3361 tgcccggagc cgcccggttc gccgacgcgc tggcggcgga caccgagcgg gcggcgcgcc
     3421 aggtgcggga acggcgcaga ccgcgctggg accggaccaa ggaggccctg gtcgactggg
     3481 aaaccgacag caccgcggag gcggtggtcc agagcggggc ggagctgctc gtacggtccc
     3541 tggaccagct ggcgaccgcc atggaccggg cgcccctgga acgggacacc gaggcggccc
     3601 ggcagcagcg gccctagctg cggaaccgct cggcgagtgc ggccatcgtg tcgaggtggg
     3661 cgagcgtctc gccctccggc ttcgtcggca ggtacagcag cacccggtcc acgccgagcc
     3721 gccgataccc ctccagcgcc tcggcggtgt cgggcaccgc gtacaccgtc accggcacgt
     3781 cccggcctgc cacctgccgc agccgctcga tctgcggggc cagcccgtcg ggcggcacgc
     3841 tgttggccag ccacgcgtcg ccgtgcgcgg cgatccgggg gaacgcggcc tcgccgccgc
     3901 ccacgtagac cggcggatgc ggacgctgga cgggcttggg ccactggtag acggggtcga
     3961 agttcacgaa ctcgccgtgg tactccgcct tctccttcgt ccacagctga acgatcgcct
     4021 ccagccgctc gtccaccaga cggccgcgcg tggacgggtc ggtaccgtgg ttctccatct
     4081 cctcgcggtt ccatccgacg cccaccccga agacggcccg cccgccggag accacgtcga
     4141 gggaggccac ctcctgcgcc gtgatgatcg ggtcccgctg tgccaccagg gcgaccccgg
     4201 tccccagcag cagccgggtg gtgaccccgg cgatgacgct cagcgtcacg aaggggtcga
     4261 gggtgcggta gtagatctcc ggcagttcgc caccgcccgg gtagggcgag cggcgttcca
     4321 cggggatgtg gctgtgctcg gcgatgaaga gtgagtcgaa cccccgctcc tcgagggcgc
     4381 gccccagggc ggcgggcccg atgccctggt cggtcacgaa ggtcgatacg ccaatcctca
     4441 cggcggctcc tcggtcggcg actccacggt ccggcatgcg cgtaggcaca agggtgatcg
     4501 acgagtaccc ccggaatcgt ccgtcacacg taacggatcg acgttccgcc gacggccgcg
     4561 aaatacgacc ggaggtcggc agttcttcaa gtgatcggca catccattcc acagaagtcg
     4621 cgtgtagcgc acgtcgccgg cgccgcgcga tcacggtgtg cggcggccgc gcccgggaat
     4681 gcgcggattt ccgcccggag gtgaagggcg acgccgcgcg agttatgacg ctggtgtgcc
     4741 gggacagtgc cggtgacgtg ggcaggtgtg cacgccatgt gatcggaaag ttggcggaat
     4801 gcgtagttcc ggatgcaccg cgattcgaag gtgtcgagcg ggcgtggtta catccttccg
     4861 cgccgagacg ttcccgggaa cccggtttcc gggaagcgcg ggaacgtgcc gcggttggcc
     4921 gacgtgggag ccgatgcatt tcggcaacta ctggccgtta caagctcatt tcgagatacg
     4981 tatccaaggg agacgcagta atgaacaacg cacccaaggt cgcgacccag gagatctccg
     5041 acgctgagct ggacaacgtg gccggcggtc tcggggctgt gggcgacgcc ctgggcaccg
     5101 tgcagtccgt caccggtccc gtcaccggcc cggtcaccgg cgccgtgggc accgtcaccg
     5161 gcaccgtcga cggcgcgacc ggcctgaaca cctccggcat cgtcggcacg gtcgcgggtc
     5221 tctgagacca ccgcgtccac cccatgcccc gggcctgcct ggcccggggc atgcgcggtt
     5281 ccccggcacc cgtcgtacgg gccgcccgga ccgcgcaccc gacccgttcc ctcgcgcccc
     5341 ccggccggtt gagaaaagac tcccgtgcag ttccgccagc aggccctttc caagctccag
     5401 tcggcagacg acatcgacct gccggtccgc tacgcccgcc cccagggctg gctcgcgctg
     5461 gcggtcaccc tcgtcgccat ggccgcggcc gccgtctggg ccgtgaccgg caccgtgggg
     5521 gacaccctgg gtgcctccgg catcctcacc cacggccagg gcagctatgt gctccagagc
     5581 ccggtcaggg gacaggtcac cgccgtgctc gccaaggagg gcagcacggt gcgggcgggc
     5641 gccccgctgg tgaaggtccg taaccccggc ggaggagcca cgttcgtacg cgccctcgcc
     5701 gccggccgcc tcaccaccct gtcggtctcg atcggctccg tgctcaacac cggcgcggac
     5761 gtcgcctccg tggagcgcgt ccgcgactcc cgcgacccgc tgaccgcgac cctgtacgta
     5821 ccggcggacc gggcggcgtc ggtgcccgcg ggcgccacgg tcgacctcga tgtgcagtcg
     5881 gcgccctccg ggacgtacgg cgtgctgcgc ggccatgtcc aggcggtcgg ccggaccgcc
     5941 cagtcgcgca aacagatcgg ctccttcctc ggcagcgccc agctcggcga ggagttctcg
     6001 aagcagggcc cgccggtcgc ggtggcggta cgcctcgacc gttcctccgc cacccgctcc
     6061 ggctaccgct ggtcctcgcc gaagggcccg ccgttcgccc tcggctccat gaccctggcc
     6121 tccggcacca tccacctggc cgaccgtcac cccgtcgatt ggctgctccc gtgaccgcga
     6181 cgaacccgac gaatccgccg aacccggccg gcgcgacgaa cgagagcggc ggaccgcccc
     6241 gccccgcacc cgccgggacc agcggacgcc gccgccccga accggcccgc ggacgccgcc
     6301 gcgcaccgcg gcgcgggagc gggccgaaga agccggggcg gcggaccgta cgcaccccca
     6361 ccgtgctcca gatggaggcg ctggagtgcg gtgccgcgtc gctcgccatg gtgctcgccc
     6421 actacggacg ccacgtaccg ctggaggagc tgcggatcgc ctgcggcgtc tcccgcgacg
     6481 gatcgcgcgc cagcaacgtg ctgaaggccg cccgcagtta cgggctgcgc gccaagggca
     6541 tgcagatgga gcccgaggcg ctggccgagg tccaggcccc ggcgatcctg ttctgggagt
     6601 tcaaccacta cgtcgtctac gacggcatgg gacggcggtt cggcaagcgc ggcgtccaca
     6661 tcaacgaccc cgacaagggg cgccgcttcg tctccgccga ggagttcgga gcgagcttca
     6721 ccgggatctg cctggtcttc gagcccgatg cctccttcag ccgcggtgga cggaagcccg
     6781 gcatcctgaa cgccctgccc gcgcggctgc gcggcaccgg cggcaccctg gtcgcctcgc
     6841 tgctggccag cctgctgctg gtggcggtgg gcgccgcggt gcccgcgctc agccgcacct
     6901 tcatcgacac cttcatcgtc ggcggccaga cctcgatgct gccaccgctg ttcgcgtcca
     6961 tggccgtggc ggtggtgctg accgcggtgc tgaccggcgt ccagcaggcg aatctgctgc
     7021 gcggacgcat catctcctcc accctcggca gcgcccggtt cctgcgccat ctgctgcggc
     7081 tgcccgtcac gttcttcgcc cagcgcagcc ccgccgacct ggtgcagcgc ctgcggtcca
     7141 acgacaccgt cgccgagacc ctcgcccgcg acctggccgc ggcggcggtc gacgggatcg
     7201 tggtggtgct gtacgccctg ctgctgtgga cctacgaccc ccagctcacc ctggtgggcg
     7261 tcgggctcgc gctgctcaac gtggtcgcga tgcgcatcgt gatacggctg cgcgccaccc
     7321 gcacccagaa gctgcgcgcc gacaccgcgc ggctgaccac caccgcgtac accgggctcc
     7381 agcttcatcg agaccatgaa ggccaccggc ggcgagagcg gctacttccg ccgctgggcc
     7441 ggtcagcacg ccatcacgct ggaggaacag cagcgtctcg gtgtgccgag cgcggtcctg
     7501 ggcgtggtgg cgcccaccct cgccaccctc aacagcgcgc tcatcctgtg gatcggtggc
     7561 ctgcgagccg tcgagggcca tctgtcggtc gggctgctgg tggccttcca ggcgcctggt
     7621 cacccgcttc accgcgccca tcacccggct gaacggcgtg gccgggcgca tccaggactt
     7681 ctccgcggac gtggcccggc tgggcgacgt ggagcgcttc cccgcggaca ccttccacac
     7741 ccgcgacgag gggcagccgg atgccgaggg cgcccgccgc ctcaccggcc atgtgacgct
     7801 ggaggacatc accttcggct acaacccgct ggacgaaccg ctgctgcgcg gcttctcgct
     7861 gtccgtcggc cccggccgcc aggtggcgct ggtcggcggc tccggcagcg gcaagtccac
     7921 cgtgtcccgg ctggtctccg gcctctacag cccgtgggaa ggtgccatcc gcatcgacgg
     7981 ccagcggctg gaggacatcc cccgcgggcg gctcgccgcc tcggtgtcct tcgtcgacca
     8041 ggacgtcttc ctgttcgagg gaacggtgcg ggacaacgtg gcgctgtggg acccctccat
     8101 cccggacgac gcggtggtgg ccgccctgcg ggacgccgca ctctacgacg acgtcatcgc
     8161 ccgccgcccc ggcgggatcc actgccgggt cgagcaggac ggccgtaact tctcgggcgg
     8221 acagcggcag cggctggaga tcgcccgggc cctggtccgc cgccccagcg tgctggtcct
     8281 ggacgaggtg accagcgccc tggacgcgca gaccgaacag accgtcatgg acagcctgcg
     8341 ccgccgcggc tgcgcgtgcg tggtgatcgc ccaccggctc agcaccgtcc gggacagcga
     8401 cgagatcctc gtcctggacc gcggcacggt cgtggaacgc ggacggcacg aggacctcgc
     8461 ggtcgccgga ggcccgtacg ccgagttgat gaaggagcac tgacatggcg tccgtacacc
     8521 cggccgcggc cgtggacgcc gatgggagcg acgcggtggt gcgggcgctg ggcgccctcg
     8581 gcaccccggt cgacggcgcc gggctgcgca gcctcccgct ggagggcccg caggtgctct
     8641 ggctcgtcgt cgcgggcgcc ctggacctct tcgcggtcga cgccgccgag gaggggcagt
     8701 ggcacttcct cggccgcctg gagacgggcg ccgcgcttcc cgggcccgtc gagggcccgc
     8761 gccacaccct gctcgggcgg ccctcgcagg actgcgcgct gcgccgcatc ccgctgcgcg
     8821 agctgtaccg gccggagcgg tacgacgcgt acggcacccc gtacgacacc acgtacggga
     8881 ccgagggcgc gtacgcggac gacggcgggt tccaggaagc cccgacgccg ctggagcacg
     8941 ccgttgcgct cggcatcagc cgcagcctcg gcgtactgtt ccaggccccg ctggacgggg
     9001 gagcgtcgcc cggcgaggag gcggccgacg aggacctgct gtggctcccg gtgccgcccg
     9061 gcagcgtgtg ctacggcgcc gagtacagcg cccaggccgc cggagacctg ctgatcgacg
     9121 gcgcgctgtg gcagcggatg gtcaaccagc agtaccggct cggcaccacc gtggaccgct
     9181 ggatcgacac cctggaacgg gcccacgccg accggacggc cgccggtatc cgggccggtg
     9241 aggccgtacg ctcgcgcgcc gacgaggcgc tcatcgcgtc catcggcggc ccgcggcgct
     9301 cgcccggggc ctcggacgac agcaccgacg acgccgtgca cgcggtctgc cgggcggtgg
     9361 cggacgccgc cgggatcacc ctcgccgaac cgcccaaggg ccccgccccc gacgaccgca
     9421 tggaccccgt ggagcgcatc gcggcccacg cccgcatccg cacccgcgcc gtccggctgg
     9481 agggccgctg gtggcgcgag gacgccggac cgctggtggg ctaccgcgcc ctgtccgggg
     9541 cgccggtggc gctgctgtgg cggcgcggcc ggtacgaggc cgtcaacccg gcctcgggcc
     9601 tgcggatacg catcggccgc ggcaccgcgg aggagttcga gccgcgcgcc gtgatgttct
     9661 accgcccgct gcccgagcgg ccgatgacga tgtggcggct gctgcgcttc acggcccgcg
     9721 gcgccgcgcc ggacctgcgc agcctgttcg ccgccggtct tgtgacggtg gcgctgggcg
     9781 ccctggtgcc gatcgccacc ggtcaggtgc tcggcgggtt cgtcccccgc gccgagaaga
     9841 gccccatcgt ccagatcgcc ctggcgctga tcgtctccag tgtcgtcgcc gcgtccttcc
     9901 tgctggtcca gaacctgacc ctgctgcggc tggagggacg gctggagagc acgctccagc
     9961 ccgccgtctg ggaccggttg ctgcggctgc ccaccacgtt cttcgcggag cgctccaccg
    10021 gcgaactcgc cagcgcggcc atgggcatca gcaccatgcg ccgggtgctg tccggcaccg
    10081 cccccgtggt gctccaggcg ggcaccgtcg gggcgatgaa cctcggcctg ctgctgttct
    10141 tcagtgtgcc gctcgcgctc gccgtgatgg gcatgctgct ggtcgtgtgc ggcatcttct
    10201 tcgccatggg cctgtggcag gtgcg
//
