LOCUS NZ_GG657754 22259 bp DNA linear CON 01-MAY-2024 DEFINITION Streptomyces himastatinicus ATCC 53653 supercont1.1, whole genome shotgun sequence. ACCESSION NZ_GG657754 VERSION NZ_GG657754.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces himastatinicus ATCC 53653 ORGANISM Streptomyces himastatinicus ATCC 53653 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group. REFERENCE 1 (bases 1 to 10901646) AUTHORS Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M., Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D., Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T., Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T., White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R., Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B., Nusbaum,C. and Birren,B. CONSRTM The Broad Institute Genome Sequencing Platform, Broad Institute Microbial Sequencing Center TITLE Annotation of Streptomyces hygroscopicus strain ATCC 53653 JOURNAL Unpublished REFERENCE 2 (bases 1 to 10901646) AUTHORS Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q., Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z., Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A., Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S., Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T., White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R., Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J., Nusbaum,C. and Birren,B. CONSRTM The Broad Institute Genome Sequencing Platform, Broad Institute Microbial Sequencing Center TITLE Direct Submission JOURNAL Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA REFERENCE 3 (bases 1 to 10901646) AUTHORS Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q., Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z., Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A., Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S., Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T., White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R., Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J., Nusbaum,C. and Birren,B. CONSRTM The Broad Institute Genome Sequencing Platform, Broad Institute Microbial Sequencing Center TITLE Direct Submission JOURNAL Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Arachne v. April 2007 Genome Coverage :: 6x Sequencing Technology :: ABI ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_000158915.1-RS_2024_05_01 Annotation Date :: 05/01/2024 03:02:38 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,680 CDSs (total) :: 9,608 Genes (coding) :: 8,720 CDSs (with protein) :: 8,720 Genes (RNA) :: 72 rRNAs :: 4, 1 (5S, 16S) complete rRNAs :: 4, 1 (5S, 16S) tRNAs :: 64 ncRNAs :: 3 Pseudo Genes (total) :: 888 CDSs (without protein) :: 888 Pseudo Genes (ambiguous residues) :: 0 of 888 Pseudo Genes (frameshifted) :: 423 of 888 Pseudo Genes (incomplete) :: 530 of 888 Pseudo Genes (internal stop) :: 36 of 888 Pseudo Genes (multiple problems) :: 97 of 888 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 20:01:42 NOTE :: This is a single region extracted from a larger record! Orig. start :: 5442905 Orig. end :: 5465164 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to GG657754.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Annotation was added to the scaffolds in August 2010. FEATURES Location/Qualifiers region 1..22259 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene" /region_number="23" /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /tool="antismash" cand_cluster 1..22259 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" protocluster 1..22259 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:12259](+)" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core 10001..12259 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" gene complement(56..571) /locus_tag="SSOG_RS23075" /old_locus_tag="SSOG_04563" CDS complement(56..571) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014177805.1" /locus_tag="SSOG_RS23075" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04563" /product="hypothetical protein" /protein_id="WP_039938440.1" /transl_table=11 /translation="MYFAALLARTAEGWEASDTELDDVETLTDLIDLARGAAKDDDTVL AFIEHEDAWFGVVRVDGEEDPHIYVSDAAAAARTSYGSMLTDELLGRDPDDDLDSLVDL DGTEDGEPDQDDDADPDAPVPVGPLGDGDILTDLGMEEKELKSLDGDALESIADMLGCS MEGLEAVR" gene complement(767..967) /locus_tag="SSOG_RS23080" CDS complement(767..967) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007265354.1" /locus_tag="SSOG_RS23080" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="WP_078510376.1" /transl_table=11 /translation="MTDTDMPTGRTMGAVSARESAADRRRRRESFLRALNEARQVRDRV RPRLTRAARMREAIHLRTFRW" misc_feature 1036..1049 /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: medium, score: 20.46" /tool="antismash" gene 1136..1771 /gene="upp" /locus_tag="SSOG_RS23085" /old_locus_tag="SSOG_04564" CDS 1136..1771 /EC_number="2.4.2.9" /GO_function="GO:0004845 - uracil phosphoribosyltransferase activity [Evidence IEA]" /GO_process="GO:0009116 - nucleoside metabolic process [Evidence IEA]" /codon_start=1 /gene="upp" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004943140.1" /locus_tag="SSOG_RS23085" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04564" /product="uracil phosphoribosyltransferase" /protein_id="WP_009716655.1" /transl_table=11 /translation="MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATR DVRTEQVDIETPVTATTGVRLSHPRPMVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRD EETLQASTYATRMPDDLSGRQVYVLDPMLATGGTLVAAIRELIARGADDVTALCLLAAP EGVEVMERELAGAPVTVVTASIDERLNEHGYIVPGLGDAGDRMYGTAG" misc_feature 1181..1194 /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 19.21" /tool="antismash" gene complement(1826..2497) /locus_tag="SSOG_RS23090" /old_locus_tag="SSOG_04565" CDS complement(1826..2497) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003967678.1" /locus_tag="SSOG_RS23090" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04565" /product="LytR C-terminal domain-containing protein" /protein_id="WP_039938441.1" /transl_table=11 /translation="MSMLTPPGMGGKYRITGDRYPRMRRPRSRRRLVFAALGSVVALGL VGWGTLQLIDVFSGGGGKGSDTVRAARGSADCKREPGKGRDQGAGSSSRTAAKKLPKPS DITVNVYNATKRSGLAKDTAKELEKRGFKIGDVGNAPKAYDQKVKTPGILLGAPASADG TFRVLSTQLTGATTKNDTRRGKDVDLIIGSAFKDLVKAKDADKALTALTKPSPRPSGSP C" misc_feature complement(2527..2543) /note="TFBS match to GnfM, Regulator of nitrogen-fixation genes, confidence: weak, score: 19.24" /tool="antismash" gene complement(2612..2908) /locus_tag="SSOG_RS23095" /old_locus_tag="SSOG_04566" CDS complement(2612..2908) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003949502.1" /locus_tag="SSOG_RS23095" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04566" /product="type II toxin-antitoxin system VapB family antitoxin" /protein_id="WP_009716657.1" /transl_table=11 /translation="MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKQQLDL ETLLAEDSTFYGDLFAHVVKWDGDLYLEDGLHRAVRAALQQRQVLHARVLELD" misc_feature 3012..3025 /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 15.24" /tool="antismash" misc_feature complement(3012..3026) /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: weak, score: 19.08" /tool="antismash" misc_feature 3013..3026 /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 14.19" /tool="antismash" misc_feature complement(3014..3027) /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 14.3" /tool="antismash" regulatory 3073..3244 /bound_moiety="thiamine pyrophosphate" /db_xref="RFAM:RF00059" /inference="COORDINATES: nucleotide motif:Rfam:14.4:RF00059" /inference="COORDINATES: profile:INFERNAL:1.1.5" /note="TPP riboswitch; Derived by automated computational analysis using gene prediction method: cmsearch." /regulatory_class="riboswitch" gene 3311..4787 /locus_tag="SSOG_RS23100" /old_locus_tag="SSOG_04567" /pseudo="" CDS 3311..4787 /codon_start=1 /gene_functions="other (smcogs) SMCOG1199: NmrA family protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003999483.1" /locus_tag="SSOG_RS23100" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04567" /product="SDR family oxidoreductase" /pseudo="" /transl_table=11 /translation="MRCLVTGATGYIGGRLVPELLTAGHAVRCVVRSPGKLRDHPWAGR VETVRGDVTDEESVRAAMEGVDVAYYLVHALGGGPGFEETDRRAARVFGERARAAGVRR IVYLGGLTPAGVPDRDLSPHLRSRAEVGRVLLDSGVPTAVLRAGVIIGSGSASFEMLRY LTERLPVMVTPALGAHPHPADRRPRCAPAAGRLRRAAVRGEPGLRHRRPRHPHLPRHDA AVRGRRRAAPARHRAGAGAHPGALQPLGRPDHPRARRPRAAAGGVAAA" misc_feature 4154..4156 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene complement(5018..6265) /locus_tag="SSOG_RS23105" /old_locus_tag="SSOG_04568" CDS complement(5018..6265) /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1007: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014177798.1" /locus_tag="SSOG_RS23105" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04568" /product="cytochrome P450" /protein_id="WP_009716659.1" /sec_met_domain="p450 (E-value: 8.2e-31, bitscore: 106.3, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MAHGPLLRKITDYANRADPYPIYAELRKTPVVHEEDGPYIVSTYW EIHALLHDPRISSDARNLDPRAAGEPDDAETEAEEDDPGLPPAFLKLDPPEHDRLRRLA MTPFGPPHTPRRIHAMRGELSRIVDELIDGFRDRDGIDLVDDFSYPFPVTVICRLLGVP REDEPRFHTWADTLAASLDPDPEQDAAERRRVTQQARIELGRYLSELIEERRRSPGDDM LSALVAGHGPEGGMSHTELLSTAALLLVAGHETTVNLITNGMLALLRNPDVLARLRAKP HLAVPLVEELLRYDPPVQLLPQRTPLSDIDIAGVTIPKGASVWLVLASGNRDPQRFLDP DRFDPQRRDNQHLGFGSGIHSCFGAPLARLEAQLALTALAKRLDNPRLREDPPPYRRNA VLRGPRHLPITLDGLR" gene complement(6408..8047) /locus_tag="SSOG_RS23110" /old_locus_tag="SSOG_04569" /pseudo="" CDS complement(6408..8047) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020116560.1" /locus_tag="SSOG_RS23110" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04569" /product="IS200/IS605 family accessory protein TnpB-related protein" /pseudo="" /transl_table=11 /translation="MDRVREMAAPFVVPGPAGTAIRARLHVSETDAAVLTEVGAFLGTL AAGDLAVRSRQGLEHGGQSWAVRKRELTGVSSARWAGSITKATHDQWALARRGQAAEMA WLRKQIASMEARLARPLGAKADKREGLPRGYGSRAEWHAKSRRMHALRARLAGVEVDWA AGRVRVARGGKKLAHLRHHLDQAGLSEQAWRERWRAARMFLSADGESGKLLGNETIRIT ATGQLSIKLPAPLARLVNAPHGRYALDATAAFHHRCEEWRDRITDNRAVAYRIHHDAPR GRWYVTASWQRAPAPVLPLEAALARGVVAVDMNDDHLAAWRLDIHGNPVGEPRRFSYGL SGSAQHRDAQIRHTLTRLLHHTRATGAGALAVEDLDFTDGRCREKYGRNKRFRRLISRF PTAKLKARLVAMAAEQNIAIVAVDPAYTSRWGAQHWQQPLTTSNRKVSRHDAASIAIGR RALGHPIRRRTTPPHDDQRGLPCSSEAESLGKIAVGVGPPRLDRMPSGVRDPAPAFPDQ GRDPCRRTRSERGRPVHP" misc_feature complement(7973..7975) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 8531..9802 /locus_tag="SSOG_RS23115" /old_locus_tag="SSOG_04570" CDS 8531..9802 /GO_function="GO:0016747 - acyltransferase activity, transferring groups other than amino-acyl groups [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014061819.1" /locus_tag="SSOG_RS23115" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04570" /product="acyltransferase family protein" /protein_id="WP_009716661.1" /transl_table=11 /translation="MNISSLRRAQRAPAPGPVPPPVSSSVPLPVPSSSAAPKQRDAFFD NAKYLAIVLVAMGHSWEPLRDGSRAASALYMFVYAFHMPAFILISGYFSRNFDFRADRL KRLLTGVVVPYVIFESVYSLLKGWAGDDPSYPISLLDPWYLTWFLIALFVWRVATPVWR IVRHPVPLSLAIAALASCSPDIGDDLDLQRVLQFLPFFVAGLHMRPEHFRMVRRREVRM VALPVAAAALVFAYWAVPRMNAGWFYHRDSAQEMGAPWWSGIVMTFALFGCSMVLTACF FAWVPGRTMWFTALGAGTLYGYLLHGLLIKGSHFAGWYEPSWLHTPAGAIVVTVIAAVV VTALCSPLVQRMLRFAMEPRMEWAFRSASASASSGSGSEAGAAAAAAGSGAVVAGSGPG AVVARSAAMPPRAVVPAQATRPPG" misc_feature 8546..8548 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 10001..12259 /locus_tag="SSOG_RS23120" /old_locus_tag="SSOG_04571" CDS 10001..12259 /EC_number="4.2.3.-" /GO_function="GO:0010333 - terpene synthase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0046246 - terpene biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene: T1TS" /gene_functions="biosynthetic-additional (smcogs) SMCOG1052: Terpene synthase/cyclase metal-binding domain protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016578885.1" /locus_tag="SSOG_RS23120" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04571" /product="terpene synthase family protein" /protein_id="WP_009716662.1" /sec_met_domain="T1TS (E-value: 6.6e-83, bitscore: 278.6, seeds: 237, tool: rule-based-clusters)" /transl_table=11 /translation="MTQPFQLPDFYMPYPARLNPHVQEAREHSTRWARERGMLEGSGIW EQEDLDAHDYALLCAYTHPDCSAAELALITDWYVWVFFFDDHFLERFKRSQDRAGGKAY LDRLPLFMPMDPAAAGMPEPENPVEAGLKDLWLRTVPAMSPDWRARFRESTENLLNESL WELSNINAGRTPNPVEYIEMRRKVGGAPWSAGLVEHAVGAEVPAVIAESRPLRVLRDAF ADAVHLRNDLFSYQREIEEEGERSNGVLVLETFLGCTTQQAADAVNDLLTSRLQQFENT TFTELAPLFAEHGLDAVACADVMAYVKGLQDWQSGGHEWHMRSSRYMNGGGVAAGEPAW SPFSVSGLGVGGVSGLGVSAADIRLTTGRAERARARGFSHVPHQRVGPSRLPDFFMPFT ARLSPHLDRARRNLIEWSHRMGLFGPQPGALDSCVWDEHRLLAADLPLCAAGIHPGASP DELDLTSGWLTWGTYADDYYPQVFGRRRDLTGAKACNERLKTFMPVDAGPAPVPAGGLE RSLADLWARTAGPMEEGARRVFRQAVDDMLDSWLWELANQAQHRIPDPVDYVEMRRHTF GSGLTMSLCRLAYGRRVPPDIYDSGPVRSLESAAMDYATLLNDVFSYQKEIEFEGEVHN GVLVVQNFFDCDYPTGVAIVQDLMTSRMRQFQHVAAHEFPVLYEDFGLSAEGRAVLEGY VRDLQNWMAGILTWHREVARYREEELRYQAGAPRLLRQLFGPTGLGTSAARLPVGAGR" gene 12394..12630 /locus_tag="SSOG_RS23125" /old_locus_tag="SSOG_04572" CDS 12394..12630 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020556040.1" /locus_tag="SSOG_RS23125" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04572" /product="hypothetical protein" /protein_id="WP_009716663.1" /transl_table=11 /translation="MSRRKLLVLLPVVPALALLASVWLPFVNAERLWFGMPSLYVWVGG WVLMLTPALAAVEWGLFRHGERVAAGAAAGEAQ" gene 12627..>14146 /locus_tag="SSOG_RS53825" /old_locus_tag="SSOG_04573" CDS 12627..>14146 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="SSOG_RS53825" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="SSOG_04573" /product="hypothetical protein" /protein_id="WP_063631590.1" /transl_table=11 /translation="MSVVLAVSLLGMCALALCGFLGRTGRSTDLAEWAVGRRNFGTAAM WFLQAGEVFTTFSFLGVAGVAYSGGNAATYAVVYLALAFLLLYFVQPRLWRLGKENGYL TQADYFTDRYRSPLFGKVVAVIGLIFLLPYIQLQLTGLGMVVGLVTGSTASGRLSMVLA SVLTAAFVLWSGIRGLKNSAYFKDVLTVGVMAVLAVVVPLHYVGGGVGEVFRRVHEVQP QMLTVHGGAQDQVWWTTSVLVSAIAGGMMATPHHWPPLMAAGSPRAIRTNNIFMPLYQV ALMIPIMVGLTGVAVRIGGNGDGVLLTLAQGALPDWATGLVVVAAAASAMVPAGAMCIG ISTLVAQNLLPPGRESARMRVNHSVVVLAIGLALTLGILRPGLLADLQLLTVSGFIQLV PGLLAVLGARRLLTTRAALAGLAAGEAVVTWLTLAEVDVRHVNAGLVGLAVNVAVALLV HLLLPHPTPAGASTPAPPRASAPDTGPRTATATAAPRSDESPPPLKARG" gap 14147..14624 /estimated_length=478 gene 14739..16169 /locus_tag="SSOG_RS23135" /old_locus_tag="SSOG_04574" CDS 14739..16169 /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1105: amidase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014061816.1" /locus_tag="SSOG_RS23135" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04574" /product="amidase" /protein_id="WP_009716665.1" /transl_table=11 /translation="MTDHDDELCYKTARELSALLRGREVSAREVVRAHLERIERVNPEV NAIVTLVADRALDAAAAADERIVAAGADGVGVLHGLPIAHKDTHNTAGIRTSHGSPLVD GIPDQDDLIIERIRDAGAITLGKTNVPEFAAGSHTFNPIFGATHNPYAPDRSAGGSSGG AAAALASGMVPIADGSDTGGSLRNPASFNNVVGLRPSPGRVPTWPASNAWTTLSVKGPM ARTVADTALLLSAMAGPDPRSPIALEEPGARFARPLDRDLTGLRVAWSPDLGGLVPVEP EVAAVVEASAGVFEDLGCVVERACPDLSEGEEVFRTQRAALFEVAFGPLMDRHPEGLKQ TIRENAEAGRRLTGPEVARAEVLHTALFHRVRAFFERYDVLLLPVSQVPPFDIGIEYPT EVAGVAMGDYLEWMRSAYLVTSTGSPALSVPAGFTPAGLPVGLQIVGPHRADFAVLQIG HAFEQATGYGRRRPEAIG" gene 16264..17463 /locus_tag="SSOG_RS23140" /old_locus_tag="SSOG_04575" CDS 16264..17463 /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF037653.4" /locus_tag="SSOG_RS23140" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04575" /product="helix-turn-helix domain-containing protein" /protein_id="WP_167542504.1" /transl_table=11 /translation="MSGGAMYDDSPDGLLALANSIAGLVGAPVTIEDDASELITYSPGQ EYSDDARVATILSRRVPDRYRPLLRNDRLDVRLAGSSVPLYADFRASGAAPDVLPRAIM PIRVDDLSVGSIWAIVPTAPSREQRAALEEAAALAAPVLARQIARRRGEEARRAAAVRA LLGGGAGAVEAAAELPLAPGPLAVVALRPLSPAPSGEPLRRALAGLDALAGPALGGVHA EADGAGYAVLPVRDEQRLARVVRELQDRSGLVAGVGRTVPGPDTLDRSRADADLVVRLL TRLGGVGGAAAHIRDVHLDALLMQTVDLADEAGHDPLGAIAELERYDRERGTDLLDSLA RYLATGEDARLAARQLHVHPNTLRYRLRRAHEIAGLDLTDPAAKFEIQLRLRLRALRLP " misc_feature 17498..17514 /note="TFBS match to NtrC, Nitrogen regulatory protein C, confidence: medium, score: 22.96" /tool="antismash" gene 18096..>18461 /locus_tag="SSOG_RS23145" CDS 18096..>18461 /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014061815.1" /locus_tag="SSOG_RS23145" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="FAD-dependent oxidoreductase" /protein_id="WP_039938445.1" /sec_met_domain="DAO (E-value: 1.7e-17, bitscore: 63.2, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MSTPRSAVVVGAGIVGLATAWALQSRGVEVTVAERRRPAAGASWG NAGWLTPALAMPLPEPAALRYGVRSLVTPTSPVYIPPRADPRLARFLLSFTRHCTPRRW RVLATTFAALNFFALAAY" gap 18462..18732 /estimated_length=271 gene <18733..19332 /locus_tag="SSOG_RS23150" /old_locus_tag="SSOG_04576" CDS <18733..19332 /EC_number="1.-.-.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0071949 - FAD binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1103: FAD dependent oxidoreductase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014061815.1" /locus_tag="SSOG_RS23150" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04576" /product="FAD-dependent oxidoreductase" /protein_id="WP_009716667.1" /sec_met_domain="DAO (E-value: 1e-30, bitscore: 106.7, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="RGGKVVEQAEVSGIRDLGTGVAVGTSQGDLRADVAVVSTGTWLNR LVRPFGVRVPVQSGRGYSFSVPAAGAPARPTYLAGQKVVCTPLGDGRVRVAGMMELAPP ERPVDPRRIQAIIAAARPLLRDVDWDARRDEWVGSRPCTADGLPLVGPTASPRVYVNGG HGMWGVALGPLTGRLLADAITTGTAPAELAALHPLR" gene 19401..19859 /locus_tag="SSOG_RS23155" /old_locus_tag="SSOG_04577" CDS 19401..19859 /NRPS_PKS="Domain: Polyketide_cyc (9-110). E-value: 1.9e-16. Score: 52.5. Matches aSDomain: nrpspksdomains_SSOG_RS23155_Polyketide_cyc.1" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009716668.1" /locus_tag="SSOG_RS23155" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04577" /product="SRPBCC family protein" /protein_id="WP_009716668.1" /transl_table=11 /translation="MSTVRETVEVEVPLHTAYNQWTQFTEFPRFMEGVDQVTQVDDRHN HWSTSIAGVHREFDTEIVDQLPDERIAWRTTSGEVQQQGLVTFRSLDATHTEVNLAMVF EPSGMAEKAADMTGTLDRRIKGDLHRFKDFIEHRGQEEGGWRGRISPG" aSDomain 19428..19730 /aSDomain="Polyketide_cyc" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_SSOG_RS23155_Polyketide_cyc.1" /domain_subtypes="Polyketide_cyc" /evalue="1.90E-16" /label="SSOG_RS23155_Polyketide_cyc.1" /locus_tag="SSOG_RS23155" /protein_end="110" /protein_start="9" /score="52.5" /tool="antismash" /translation="VEVPLHTAYNQWTQFTEFPRFMEGVDQVTQVDDRHNHWSTSIAGV HREFDTEIVDQLPDERIAWRTTSGEVQQQGLVTFRSLDATHTEVNLAMVFEPSGMA" misc_feature complement(19449..19463) /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: weak, score: 20.71" /tool="antismash" gene 19995..20789 /locus_tag="SSOG_RS23160" /old_locus_tag="SSOG_04578" CDS 19995..20789 /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1195: IclR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010043927.1" /locus_tag="SSOG_RS23160" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04578" /product="IclR family transcriptional regulator C-terminal domain-containing protein" /protein_id="WP_039938446.1" /transl_table=11 /translation="MGTPGGPTLITSVQRAFRLMEAVGAHEGGAPAKQLAREAGLPLAT AYHLLRTLVHDGYVHRLPDGGFVVGDKLHTLQVGSRGQALLNRVRPTLAGLRDTLSAAA YLTFYEDGEIRVAEIVDSPRAPRVDLWVGFEDAGHATALGKCVLRELGDEARSDYLSRH PLADLTPRTVTRPAELLRRLDASAAGEPVIDLEEYTLGTVCFAVPVYSGDQLGSLGVSL QAGRAGLAGQTGQGDRAARLEEIRERLLPTADRVTRSLSLTI" gene 20898..22019 /locus_tag="SSOG_RS23165" /old_locus_tag="SSOG_04579" CDS 20898..22019 /EC_number="3.1.3.16" /GO_function="GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1054: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006607830.1" /locus_tag="SSOG_RS23165" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SSOG_04579" /product="PP2C family protein-serine/threonine phosphatase" /protein_id="WP_009716670.1" /transl_table=11 /translation="MIQARNHLDQPYPPAPFAAGVPVLILGAVAVIAFVTGDGTSWLPL LAVGPALAAAACRPWAVLRIGFLAVALGVGLGAWQAAPVHGQAVVLSTLIAVTLASCLA SVLRRRRERVLAAVRSVAEAAQNALLRPVPARVGQFQVAVRYSAAAAEARVGGDLYALV STPYGVRLIVGDVRGKGLPAVSTAALVLGVFREAAYDEPDLLDVVGRIERSLARNLAPD DFVTAVVAGYPADGRMEIVNCGHAPPLLIGPAGAVVPVEPVRPAPPLGLASLGGEAPSL EVVPFADGDQMLLYTDGVIEARDHGRSYFPLAERVPGHVSDEPSRTLAGLHDELLAHVG GRLHDDAALLLLRKPASGRVGQAVDAAADTTGV" misc_feature complement(20918..20933) /note="TFBS match to DasR, N-acetylglucosamine dependent repressor, confidence: weak, score: 20.3" /tool="antismash" ORIGIN 1 gggtccgggc aggatgccgg tcagcggatc ggtcatgtca ccagtgtggc ggcggtcagc 61 gcaccgcctc caggccctcc atgctgcatc ccagcatgtc cgcgatcgat tcgagcgcgt 121 ccccgtcgag ggacttcagt tccttctcct ccatgcccag gtcggtcagg atgtcgccgt 181 ccccgagggg gcccaccggg acgggtgcgt cggggtcggc gtcgtcgtcc tggtcgggct 241 cgccgtcctc ggtgccgtcc aggtcgacga ggctgtccag gtcgtcgtcg gggtcccggc 301 cgagcagctc gtcggtgagc atcgagccgt atgaggtgcg ggcggccgcg gccgcgtccg 361 atacgtagat gtgcgggtcc tcctcgccgt ccacgcggac gacgccgaac cacgcgtctt 421 cgtgctcgat gaaggccaga accgtgtcgt cgtccttggc ggccccacga gccagatcga 481 tcaaatcggt cagagtctcc acgtcatcga gctctgtgtc gctcgcttcc cacccttctg 541 cggtgcgcgc gagcaatgcg gcgaagtaca ccgtgactct cccactggtc ataggcgtgc 601 cggggcgggc gggacagtgt cccgccccaa tcggaatcgt ggcagaaacc atcgcttcgc 661 gagaggtctt ccgcgctgcg tcgtgcacca gtccaaagag atgtggctca cgtgaaacga 721 aacggaccga cctgatcgct ccatcggcgg tgcgccgggt tcgggttcac cagcggaacg 781 tgcgcagatg tatcgcctcg cgcatgcggg cggcgcgggt cagccgcggc cgtacgcggt 841 cgcgcacctg ccgggcctcg ttcagcgcgc gcaggaagct ttcgcgtcgt cggcggcggt 901 ccgcggcact ctcgcgtgcg gacacggcgc ccatcgtcct gccggtgggc atgtcggtgt 961 cggtcatggc ctcacccctc gggccgaggt gtccgcccgg acgtggggcc cgggcgctcc 1021 tgcccacttt cccccgaaac ggcggtttga tgccagtaca gcgacagact gtcgtcgcgc 1081 gccggagggt taccggcggg agccgcgacc ggagggctcc gttagtgtcg ttgccatgcg 1141 gatccacgtc gtcgaccacc cgctggtggc gcacaaactc accacgctgc gcgacaagcg 1201 caccgactcc cccacgttcc ggcggctcgc cgacgagctg gtgaccctgc tcgcgtacga 1261 ggccactcgc gatgtgcgga ccgagcaggt cgacatcgag accccggtga cggcgacgac 1321 cggggtgcgg ctgtcgcatc cgcgccccat ggtggtgccg atcctgcggg cgggcctcgg 1381 gatgctcgac ggcatggtgc ggctgctgcc gacggccgag gtgggcttcc tcgggatgat 1441 ccgcgacgag gagacgctcc aggcgtccac gtacgccacc cggatgcccg acgacctctc 1501 cggccgtcag gtgtacgtgc tggacccgat gctggcgacc ggcgggacgc tcgtcgcggc 1561 gatccgggaa ctcatagcgc gcggcgcgga cgatgtcacc gcgctgtgtc tgctggcggc 1621 gcccgagggc gtcgaggtga tggagcgcga gctggcgggc gcgcccgtga cggtggtcac 1681 cgcgtccatc gacgagcggc tcaacgagca cgggtacatc gtgccggggc tcggcgacgc 1741 gggcgaccgg atgtacggga ccgcgggcta ggcccgtccg gtcccgttca acggggcggc 1801 gcgggccggg cccgcccggt cccgttcagc agggcgagcc cgacgggcgg ggcgagggct 1861 tggtcagcgc ggtgagcgcc ttgtcggcgt ccttcgcctt gaccaggtcc ttgaaggccg 1921 agccgatgat caggtcgacg tccttgcccc ggcgggtgtc gttcttggtc gtggccccgg 1981 tgagctgggt ggagagcacc cggaaggtcc cgtcggcgga ggccggtgcg cccaggagta 2041 tccccggggt cttgaccttc tggtcgtacg ccttcggggc gttccccacg tccccgatct 2101 tgaagccgcg cttctccagc tccttggcgg tgtccttggc gagcccggag cgcttggtcg 2161 cgttgtagac gttgacggtg atgtcggacg gcttcggcag cttcttcgcc gccgtacggg 2221 acgacgaacc ggcgccctgg tcgcggccct tgccgggctc gcgcttgcag tccgcgctgc 2281 cgcgcgccgc gcgcaccgtg tcgctgccct tgccgccgcc accggagaag acgtcgatga 2341 gctgaagcgt tccccagccg accaggccga gtgccacgac cgagccgagg gccgcgaaga 2401 ccaggcgccg gcggctccgg ggccggcgca tgcgcgggta gcggtcgccc gtgatgcggt 2461 actttccgcc catgccagga ggggtcagca tgctcatgtg cgcagcgtag tgcggcctgg 2521 tgacgatgcc tactaaatga tcaatggttg gtgtgcagtc caacccgaaa gggccaatgc 2581 gaaggcccgg tcacccctcg ccgggacggc gtcagtcgag ctccaggacg cgcgcgtgca 2641 gcacctggcg ctgctggagc gccgcgcgca ccgcgcggtg cagcccgtcc tccagataga 2701 ggtcgccgtc ccacttcacg acgtgggcga agaggtcccc gtagaacgtc gagtcctccg 2761 cgagcagcgt ctccagatcg agctgctgct tcgtcgtgac cagctggtca agacgtaccg 2821 ggcgtggggc gacatccgcc cactggcggg tactttcccg gccgtggtcg gggtagggtc 2881 gaccgtttcc gatgcgcttg aagatcacac ggaaagccta ccgggcaagc ggcttccggc 2941 gcagccaagg cgccggagtg ccgggccggg ggcgcgggga ggggctccgc gacgcgctgg 3001 caaaagggtg gaattttctc gaaaagggac tagtcgccca agggggtcag gagtaacctg 3061 aatatcagcc tgcggggcga gcgagggagc tcgaccggag aggcgctcag gacagaggac 3121 tttggttctc cggaacgtct cgttgatggc cgggctgaga ggccggaagg tcggggagac 3181 cggaaggcga cctccacaac ctgatccgga caatgccggc gaagggagcc cacctcgcag 3241 gtttcgtgct gcccggctgc cttcctgtgg cccggttgcg gttggttccc gcgcgttcaa 3301 gcatggccgc atgcgctgtc tggtcaccgg ggccaccggc tacatcggcg gcaggctcgt 3361 ccccgagctg ctgaccgcgg ggcacgcggt gcgctgtgtg gtccgttccc ccggcaagct 3421 gcgcgatcac ccctgggcgg ggcgggtcga gaccgtacgc ggcgatgtga ccgacgagga 3481 gtccgtccgg gcggccatgg agggcgtgga cgtcgcgtac tacctggtgc acgcgctggg 3541 cggcgggccc ggtttcgagg agaccgatcg gcgcgcggcg cgcgtcttcg gcgagcgggc 3601 gcgggccgcc ggggtccggc ggatcgtcta cctcggcggg ctgaccccgg ccggggtccc 3661 ggaccgcgat ctctctcccc atctgcggtc ccgcgccgaa gtggggcggg tgctcctgga 3721 ctccggggtg ccgaccgcgg tgctccgggc cggtgtgatc atcgggtcgg gctcggcgtc 3781 gttcgaaatg ctgcgctatc tgaccgaacg gctaccggtc atggtcaccc ccgcgctggg 3841 tgcgcacccg cacccagccg atcgccgtcc gcgatgtgct ccggctgctg gtcggctgcg 3901 ccgagctgcc gtacgaggtg aaccgggcct tcgacatcgg cggccccgac atcctcacct 3961 accgcgacat gatgctgcgg tacgcggccg tcgccgggct gccccggcgc gccatcgtgc 4021 cggtgccggt gctcaccccg gggctctcca gcctctgggt cggcctgatc acccccgtgc 4081 ccggcgccct cgcgcggccg ctggtggagt cgctgcggca tgaggtggtc tgcgccgagc 4141 gggacatcag gcgttacgta cccgagccgc cgggcggccc cctcggcgtc aaccgcgccc 4201 tggagctggc cctgcggcgg atccgcgagg cggacgtggc cacccgctgg tcgtccgccg 4261 ccacccccgg cgcccccagc gacccgctgc ccaccgaccc cgactgggcg ggcggcaccc 4321 tctacaccga ccaccgccgc cgcgccgtga acgcctcccc gcaggaggtg tggcgggtcg 4381 tggagggcat cggcggtgag aacggctggt acgcgctccc cctcgcctgg gcgctgcgcg 4441 gctggatcga caccctgatg ggcggcgtcg ggctgcggcg cggccgccgc gacgcggccc 4501 ggctgcgggt cggggacagc ctcgacttct ggcgggtcga ggaggtcctg ccgccccgtc 4561 tgctgcggct gcgggccgag atgcggctgc cggggctggc gtggctggag atgcgggtgg 4621 aacgggacgc ggacggccgt accgtcttcc gccagcgcgc cgtcttccac ccgcacggac 4681 tggccgggca cctctactgg tggggcgtct cgccgttcca cgcgctggtg ttcggcggga 4741 tggcccggaa gatcgccgcc aaggccgagt cgtctgtgtg ccgttgaccg gatcgcgggt 4801 gcgctgtcac ctgcggcggg cagggcgcgg gggtcgctgg ggcgggttcc ccagcccgcc 4861 ccttcccgaa ccaggggctc cgcccctgga cccccggacg ggcccgcgcg cgccacacga 4921 gaagcggcca tcggccaccg tgccgcaacg gcccgcctgg ccggtcgggc gcggctgatc 4981 gcgccggctt tgtggtcgcc gcgccgccgg acacccccta gcgcaggccg tccagggtga 5041 tggggaggtg gcgggggccg cggaggacgg cgttgcggcg gtaggggggc gggtcttcgc 5101 gcaggcgggg gttgtccagg cgcttggcca gcgcggtcag cgccagctgg gcttccaggc 5161 gggccagcgg ggcgccgaag cagctgtgga tgccgctgcc gaagccgagg tgctggttgt 5221 cgcggcgctg ggggtcgaag cggtcggggt cgaggaagcg ttgggggtcg cggttgccgg 5281 aggccaggac gagccagacg gaggcgccct tggggatagt caccccggcg atgtcgatgt 5341 ccgacagcgg ggtgcgctgg ggcagcagct ggacgggcgg gtcgtagcgc agcagctcct 5401 cgaccagggg gacggccaga tgcggcttgg cgcgcagccg ggccaggacg tcggggttgc 5461 ggagcagcgc gagcatgccg ttggtgatca ggttgacggt ggtctcgtgg cccgcgacca 5521 gcagcagcgc ggccgtgctc agcagctccg tatggctcat cccgccctcc gggccgtgcc 5581 cggcgaccag ggcggagagc atgtcgtcgc cgggagagcg gcggcgttcc tcgatcagct 5641 cggagaggta gcggccgagt tcgatgcgcg cctgctgggt gacacggcgc cgctcggcgg 5701 cgtcctgctc ggggtccggg tcgaggctcg cggcgagggt gtcggcccag gtgtggaagc 5761 ggggttcgtc ctcgcgcggt acgcccagca gccggcagat gacggtgacc gggaaggggt 5821 acgagaagtc gtcgacgagg tcgatgccgt cccggtcccg gaagccgtcg atcagctcgt 5881 cgacgatgcg ggacagctcg ccgcgcatgg cgtggatccg ccgcggggtg tgcggcgggc 5941 cgaagggggt catggccagg cggcgcagcc ggtcgtgttc gggcgggtcg agcttcagga 6001 aggcgggcgg cagccccggg tcgtcctcct cggcctcggt ctcggcgtcg tccggttccc 6061 cggcggcccg ggggtcgagg ttgcgtgcgt cggagctgat gcgcgggtcg tgcaggaggg 6121 cgtggatctc ccagtaggtg ctgacgatgt acgggccgtc ctcctcgtgc accacgggcg 6181 ttttgcgcag ttccgcgtag atcgggtacg ggtcggcgcg gttggcgtag tcggtgatct 6241 tccgtaggag ggggccgtgg gccatggcgg agtccttccg gggatcaggg ccgcggatcg 6301 gggcgaggaa cgcgcactgc gcgtatccat ggcagccgtg gagatcgcga ttggctcggg 6361 tcgccgggtc accgttcctc atcagtgagc aggagtgact cttgtgccta aacctgcgta 6421 tctggcgcat cccgaacggt tatggatgca ctggtcgccc gcgttcgctc cgcgtccggc 6481 ggcacggatc tcgtccttgg tccgggaagg cgggggcggg gtccctcacg ccgctgggca 6541 tccggtcgag cctgggcggt ccgacgccca cggcgatctt ccccaagctc tcggcttcgc 6601 tcgagcaggg gagaccccgt tggtcgtcgt ggggcggtgt cgtccgtcgc cggatcgggt 6661 gtccgagggc gcgtcgcccg atcgcgatgc tggcggcatc gtgccgggaa accttgcggt 6721 tgctggtggt caggggctgc tgccagtgct gggcgcccca gcgggaggta taggccgggt 6781 cgaccgcgac gatcgcgatg ttctgctcgg cggccatggc caccagccgt gccttcagct 6841 tcgcggtggg gaagcgggag atgaggcggc ggaagcgctt gttgcggccg tacttctccc 6901 ggcaccggcc gtcggtgaag tccaggtcct cgacggcgag cgcccccgcc ccggtggccc 6961 gggtgtggtg cagcagccgg gtcagggtat gccggatctg ggcgtcgcga tgctgggccg 7021 aaccgctcag gccgtaggag aagcggcggg gctcgcctac cgggttgccg tggatgtcca 7081 ggcgccaggc ggccaggtga tcgtcgttca tgtcgacggc gaccacgccc cgggcgaggg 7141 ccgcttccag cggcagtacg ggtgcagggg cgcgttgcca ggaggcggtc acataccagc 7201 ggccccgggg cgcatcgtgg tggatgcggt aggccactgc ccggttgtcc gtgatccggt 7261 cccgccactc ctcacaccgg tggtggaacg ccgcggtcgc gtccagcgca taccggccgt 7321 gcggtgcgtt gaccagacgg gccagcgggg cggggagttt gatcgagagc tgtccggtgg 7381 cggtgatgcg aatcgtctcg ttgcccagga gtttgccgga ctcgccgtcc gcggacagga 7441 acatccgcgc cgctcgccac cgctcccgcc acgcctgctc gctcagtccg gcttggtcca 7501 agtggtggcg caggtgcgcg agcttcttcc cgccacgggc cactcgcacg cggcccgcgg 7561 cccagtccac ctcgactccg gccagccggg ctcgcagcgc gtgcatgcgg cgagacttgg 7621 catgccactc ggcccgcgac ccgtacccgc gcggcagtcc ttcccgcttg tccgccttcg 7681 cccccagcgg acgcgccagc cgcgcctcca tcgacgcgat ctgcttgcgc agccacgcca 7741 tctcagcggc ctgtccgcgc cgggccaaag cccactgatc gtgagtggcc ttggtgatac 7801 tgcctgccca cctcgccgac gaaacccccg tcagctcccg cttccgcacc gcccagctct 7861 gaccgccgtg ctccaggccc tgccgggaac gcacagcgag gtcacccgca gccagggtgc 7921 cgaggaacgc ccccacctcg gtcaggactg ccgcatcggt ctccgacacg tgtaaccggg 7981 cacggatggc cgtccccgct gggccgggca ccacgaacgg tgctgccatc tcccgcaccc 8041 tgtccacacc catactccca gtcggcatcg aagaccctct cgctgcgtcc aacgacctcc 8101 actcgcaaag gtcacgcatt cgaaatacgt acttctgttc ccttgaaacc gaggcccgca 8161 cgcaacgtcc cgaccgccag gtgtcagcgc tcactcgtgc ctgcaaaagc gcactcgtac 8221 gcagtcaggc cgcagctgtt ccctgggccc cagcatgggc gaggcggcag gggtccgcgc 8281 gcacagccgg gccaatgggg cgacgggcac gattccggtc ccggtgcggg gcggcgcggg 8341 ggcgggtgcg ggggcgcagt gtgccagtgg gggcgggggc gagaaccgtc gttgcgcaag 8401 agctgagtca ttccgcccgt ggccccgtgg ccgccactac cgtgcgtgga atgttccact 8461 ccgcagccct ctcctcaacc ccacaaagag gcgggatcgc cgctgtcggt tccatgaggt 8521 ggcgtatgtg atgaacatct cgtccttacg ccgcgcgcaa cgcgcccccg cccccgggcc 8581 cgtcccccca cccgtctcct cgtccgtccc cctgcccgtc ccctcgtcct ccgcggcccc 8641 caagcagcgt gacgcgttct tcgacaacgc caagtacctg gccatcgtgc tggtcgcgat 8701 ggggcattcc tgggaaccgc tgcgggacgg cagcagagcg gcgtccgccc tctacatgtt 8761 cgtctacgcc ttccacatgc cggcgttcat cctcatctcc ggctacttct cgcggaactt 8821 cgacttccgg gcggatcggc tgaagcgcct gctcaccggc gtcgtcgtcc cgtacgtgat 8881 cttcgagtcc gtgtacagcc tgctcaaggg ctgggcgggc gacgacccct cgtacccgat 8941 cagcctgctc gacccctggt atctgacctg gttcctgatc gcgctcttcg tgtggcgggt 9001 cgccaccccg gtgtggcgga tcgtgcgcca tccggtgccg ctctcgctcg cgatcgccgc 9061 gctggcctcg tgctcgccgg acatcggcga cgatctcgac ctccagcgtg tgctccagtt 9121 cctgcccttc ttcgtggcgg ggctgcacat gcggccggag cacttccgga tggtgcggcg 9181 gcgggaggtg cggatggtgg ccctgcccgt ggcggccgcc gcgctggtct tcgcgtactg 9241 ggcggtgccg cgcatgaacg ccgggtggtt ctaccaccgg gacagcgccc aggagatggg 9301 ggcgccgtgg tggagcggca tcgtgatgac gttcgccctc ttcggctgct ccatggtgct 9361 caccgcgtgc ttcttcgcct gggtgcccgg gcggacgatg tggttcaccg cgctcggcgc 9421 cggaacgctg tacgggtacc tgctgcacgg cctgctcata aagggctccc acttcgcggg 9481 ctggtacgaa ccgtcctggc tgcacacccc ggcgggcgcg atcgtggtca cggtcatcgc 9541 cgcggtggtg gtgaccgcgc tgtgctcccc gctcgtgcag cggatgttgc ggttcgcgat 9601 ggagccgcgg atggagtggg ccttccggtc ggcgtcggcg tccgcgtcgt cggggtccgg 9661 atccgaggcc ggggctgccg cggccgccgc cggatcgggg gccgtcgtgg ccggatccgg 9721 gccgggggcc gtcgtggcgc ggtccgccgc gatgccaccc cgggctgtcg tcccggccca 9781 ggccacgaga ccgccgggct agcgcgcgcc cgacctgtcg tctccggtcc cgccgcggcc 9841 gtaccgccgt ggcggggccg gaaacgatcg cacgttcatg tgactaatgg gtctgtcgga 9901 taggcggtca gggccctggg tagggccgag ccgacccgcc cgcgggggcc tgcttccggc 9961 cgcgcgggca accgtcgtac ggagaggtgc cggcccgcca gtgacacagc cctttcaact 10021 ccccgacttc tacatgccgt acccggcgcg gctgaatccc cacgtccagg aggcacggga 10081 gcactccacc cgctgggccc gcgagagggg gatgctcgaa ggctccggga tctgggagca 10141 ggaggatctc gacgcccacg actacgccct gctgtgcgcc tacacccacc ccgactgctc 10201 cgccgcggaa ctggccctga tcacggactg gtacgtgtgg gtgttcttct tcgacgacca 10261 cttcctggag cggttcaagc gctcgcagga ccgcgcgggc ggcaaggcgt atctggaccg 10321 gctgccgctg ttcatgccga tggatccggc ggcggccggg atgccggagc cggagaaccc 10381 ggtcgaggcg gggctgaagg acctgtggct gcggacggtg cccgcgatgt cgccggactg 10441 gcgggcccgg ttccgggagt ccacggagaa cctgctcaac gagtcgctct gggagctgtc 10501 caacatcaac gcggggcgga cgcccaatcc ggtggagtac atcgagatgc gccgcaaggt 10561 cggcggcgcc ccgtggtcgg cggggctcgt ggaacacgcg gtgggggccg aggtgcccgc 10621 ggtgatcgcg gagtcgcggc cgctgcgcgt gctgcgggac gcgttcgcgg acgcggtgca 10681 cctgcgcaac gacctgttct cgtaccagcg ggagatcgag gaggagggcg agcggagcaa 10741 cggggtgctg gtcctggaga cgtttctcgg ctgcaccacc cagcaggcgg cggacgccgt 10801 caacgacctg ctcacctcgc ggctccagca gttcgagaac accacgttca ccgaactggc 10861 cccgctcttc gccgagcacg gcctggacgc ggtggcctgc gcggacgtca tggcgtacgt 10921 caaggggctc caggactggc agtcgggcgg gcatgagtgg cacatgcggt ccagccgcta 10981 catgaacggc ggcggggtcg cggctggtga gcccgcgtgg tcgccgttct ccgtgagcgg 11041 cctgggcgtc ggcggcgtga gcggcctggg cgtatcggcc gccgacatac ggctcaccac 11101 cggccgggcg gagcgggccc gggcgcgcgg tttcagccat gtgccgcatc agcgggtcgg 11161 cccgtcccgg ctgccggact tcttcatgcc gttcaccgcc cggctcagcc cgcatctgga 11221 ccgggcgcgc cgcaatctga tcgagtggtc gcaccggatg ggcctcttcg ggccccagcc 11281 cggcgccctc gactcgtgcg tctgggacga acaccggctg ctcgccgccg accttccgct 11341 gtgcgcggcg ggcatccacc cgggggcgtc ccccgacgag ctggatctga cgtcgggctg 11401 gctcacctgg gggacctacg cggacgacta ctacccgcag gtctttggcc ggcggcggga 11461 cctcaccggc gccaaggcgt gcaacgagcg gctcaagacg ttcatgccgg tcgacgcggg 11521 ccctgctccc gtcccggcgg gcgggctgga gcgttccctc gccgacctgt gggcgcgtac 11581 cgcggggccg atggaggagg gcgcacgccg ggtgttccgc caggccgtcg acgacatgct 11641 ggacagctgg ctgtgggagc tggccaacca ggcgcagcac cggatccccg acccggtcga 11701 ctacgtcgag atgcgccgcc acaccttcgg ctccggcctc accatgagcc tgtgccggct 11761 cgcgtacggg aggcgcgtcc cgcccgacat ctacgacagc gggccggtcc gttcgctgga 11821 gagcgccgcc atggactacg ccaccctgct caacgacgtc ttctcgtacc agaaggagat 11881 cgagttcgag ggcgaggtcc acaacggcgt cctggtcgtg cagaacttct tcgactgcga 11941 ctacccgacc ggggtggcca tcgtgcagga cctgatgacc tcccggatgc ggcagttcca 12001 gcacgtcgcg gcccatgagt tcccggtcct gtacgaggac ttcgggctgt cggcggaggg 12061 ccgggcggtc ctggaggggt atgtgcgcga cctccagaac tggatggccg ggatcctgac 12121 ctggcaccgg gaggtcgccc ggtaccggga ggaggagctg cggtaccagg ccggggcgcc 12181 gcggctgctg cggcagctgt tcgggccgac ggggctgggg acgtcggccg cgcggctgcc 12241 ggtgggcgcg ggccggtagg gggtgtcttg tcgagccccg ccttgtcccc gcggacaagg 12301 cggggccgcc gtatgttggc cgccggtgac gatgccggac ccaggggcgg gtctgttgaa 12361 tgccgcgcag tcccctcgcg ccctggaggt accgtgtcgc ggcgcaaact gctcgtcctt 12421 ctccccgtgg tcccggccct ggccctgctc gcgtcggtct ggctgccgtt cgtcaacgcc 12481 gagcggctgt ggttcggcat gccctcgctg tacgtctggg tcggcggctg ggtgctcatg 12541 ctcaccccgg cgctggccgc cgtcgagtgg gggctgttcc ggcacggtga gcgcgtggcg 12601 gctggcgcgg cggcgggtga ggcacagtga gcgtcgtcct cgccgtatcg ctgctgggca 12661 tgtgcgccct cgccctctgc ggctttctcg gccggaccgg gcgctccacc gacctcgccg 12721 aatgggccgt cggacggcgc aacttcggca ccgccgccat gtggttcctc caggcgggcg 12781 aggtgttcac caccttcagc ttcctcgggg tcgcgggggt cgcgtacagc ggcggcaacg 12841 ccgccacgta cgccgtcgtc tatctggcgc tcgccttcct gctgctctac ttcgtccagc 12901 cgaggctgtg gcggctgggc aaggaaaacg gctacctcac ccaggccgac tacttcaccg 12961 accgctaccg cagcccgctg ttcggcaagg tcgtcgcggt catcgggctg atcttcctgc 13021 tcccgtacat ccagctccag ctcaccgggc tcggcatggt cgtcggtctg gtgaccggca 13081 gtacggcgtc ggggcggctg agcatggtgc tggcctcggt gctgacggcg gccttcgtgc 13141 tgtggtccgg tatccgcggg ctgaagaaca gcgcctactt caaggacgtc ctgacggtcg 13201 gcgtcatggc cgtgctcgcc gtcgtcgtcc cgctgcacta cgtcgggggc ggcgtgggcg 13261 aggtgttccg gcgggtccat gaggtgcagc cgcagatgct gaccgtgcac ggcggggcgc 13321 aggaccaggt gtggtggacc accagcgtgc tggtctcggc gatcgcgggc gggatgatgg 13381 cgacgccgca ccactggccg ccgctgatgg ccgcgggcag cccgcgggcg atccgtacga 13441 acaacatctt catgccgctg taccaggtcg cgctgatgat cccgatcatg gtcgggctca 13501 cgggggtggc cgtacggatc ggcgggaacg gcgacggggt gctgctcacc ctcgcccagg 13561 gcgcgctgcc ggactgggcc accgggctcg tcgtggtcgc cgccgcggcc tcggcgatgg 13621 ttccggccgg ggcgatgtgc atcggcatct ccaccctggt cgcccagaac ctgctgcccc 13681 cgggccggga gtcggcccgg atgcgggtca accacagcgt cgtcgtcctg gccatcggcc 13741 tggccctcac cctgggcatc ctgcgccccg gactcctggc cgacctgcaa ctgctcacgg 13801 tgagcggctt catccagctc gtccccggcc tgctcgccgt cctcggcgcc cgccgcctcc 13861 tcacgacacg ggccgccctg gcggggctgg cggcgggcga ggccgtggtg acgtggctga 13921 cgctggccga ggtggatgtg cggcacgtga acgccgggct ggtgggcctg gcggtgaacg 13981 tggcggtggc cctgctggta cacctgctgc ttccccaccc cacccctgcg ggggcctcca 14041 cccccgcccc gccccgggcc tccgccccgg acaccggccc gcgcactgcc acggccaccg 14101 ccgcgccgcg gtccgacgaa tcccccccgc ccctaaaggc ccgcggnnnn nnnnnnnnnn 14161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngggcgg ggtggggaac 14641 aacggctgcc gcggggctcc gggcagccaa ccgggggccg ggggcgtgcc cccggttcgg 14701 tgtggggaca attcggcaac ctacgagagc gagctaccgt gacggaccac gacgacgagc 14761 tgtgctacaa gaccgcgcgc gagctgagtg ccctgttgcg ggggcgtgag gtgtcggcgc 14821 gggaggtggt gcgggcgcat ctggagcgga tcgagcgggt gaatcccgag gtcaacgcca 14881 tcgtcaccct cgtcgcggac cgcgcgctcg acgccgcggc ggcggccgat gagcggattg 14941 tggcggcggg ggccgacggg gtgggggtgc tgcacgggct gcccatcgcg cacaaggaca 15001 cccacaacac cgcgggcatc cgcaccagcc atggttcgcc gctggtcgac ggcatacccg 15061 accaggacga cctgatcatc gagcgcatcc gggacgccgg ggcgatcact ttgggcaaga 15121 cgaacgtgcc cgagttcgcc gccggttcgc acaccttcaa cccgatcttc ggcgccaccc 15181 acaacccgta cgcacccgac cgcagcgcgg gcggcagcag cgggggcgcg gccgccgcgc 15241 tcgccagcgg catggtcccg atcgcggacg gcagcgacac cggcgggtcg ctgcgcaacc 15301 cggcctcgtt caacaacgtg gtggggctgc gcccgtcgcc cgggcgcgtc ccgacctggc 15361 ccgcgtcgaa cgcgtggacc acgctctcgg tcaagggccc gatggcccgt acggtcgcgg 15421 acaccgcgct gctgctgtcc gcgatggcgg gcccggaccc gcggtcgccg atcgcgctgg 15481 aggagccggg cgcccggttc gcccggccgc tggaccggga ccttaccggg ctgcgggtgg 15541 cctggtcgcc ggacctgggc gggctggtgc cggtggagcc ggaggtggcg gcggtcgtgg 15601 aggcgtcggc gggggtcttc gaggacctcg ggtgcgtggt ggagcgggcg tgcccggacc 15661 tgtcggaggg cgaggaggtg ttccgtacgc agcgggccgc gctgttcgag gtcgcgttcg 15721 gcccgctcat ggaccgccac ccggagggcc tgaagcagac gatccgggag aacgcggagg 15781 cgggacgccg cctcaccggg cccgaggtgg cccgggccga ggtgctgcac accgcgctct 15841 tccaccgcgt ccgcgccttc ttcgagcgct acgacgtgct gctgctcccg gtcagtcagg 15901 tgccgccgtt cgacatcggc atcgagtacc cgaccgaggt ggcgggcgtg gcgatggggg 15961 actacctgga gtggatgcgt tccgcgtacc tggtcacgtc gacgggcagc cccgccctgt 16021 ccgtcccggc cgggttcacg cccgccgggc tgccggtggg tctccagatc gtcggcccgc 16081 accgggcgga cttcgccgtc ctccagatcg gccacgcctt cgagcaggcc accgggtacg 16141 ggcggcgccg cccggaggcg atcgggtagc ggggcgagta ggggacgtcc atggacaatc 16201 cccgcgtcag cgcatcgata cggcccggtc cgggtagtgg cccccggaac cgtcggcgcg 16261 ctcatgagcg gaggagccat gtacgacgac tccccggacg gcctcctcgc cctggccaac 16321 agcatcgccg ggctcgtcgg cgcgccggtc accatcgagg acgacgcctc cgaactgatc 16381 acctactcgc ccggccagga gtactcggac gacgcccgcg tcgccaccat cctcagccgc 16441 cgggtgcccg accggtaccg gccgcttctg cgcaacgacc gtcttgatgt gcggctggcg 16501 ggctcgtccg tcccgctcta cgcggacttc cgggcgtccg gggcggcgcc cgatgtgctg 16561 ccgcgggcga tcatgccgat ccgggtggac gacctgtccg tgggttccat ctgggcgatc 16621 gtgccgaccg cgccctcccg ggagcagcgg gcggcgctgg aggaggcggc cgcgctggcc 16681 gccccggtgc tggcccggca gatcgcccgg cggcgcgggg aggaggcgcg gcgggccgcg 16741 gccgtacgcg cgctgctcgg cggcggggcg ggggcggtcg aggccgccgc cgaactgccg 16801 ctggcgcccg gcccgctggc cgtcgtcgcg ctgcggccgc tgtccccggc cccgtccggc 16861 gagccgctgc ggcgtgcgct cgccggactc gacgcgctcg ccggaccggc gctgggcggt 16921 gtccacgcgg aggccgacgg cgcgggctac gccgtgctgc cggtgcgcga cgaacagcgg 16981 ctggcgcgcg tcgtccgcga actccaggac cggtccggcc tggtggccgg ggtgggccgt 17041 accgtccccg gtcccgacac gctggaccgc tcccgggccg acgccgacct ggtcgtccgc 17101 ctcctcaccc ggctgggcgg cgtgggcggc gcggccgccc acatccgcga tgtccacctg 17161 gacgcgctgc tcatgcagac ggtcgacctg gccgacgagg ccgggcacga cccgctgggc 17221 gcgatcgccg agctggagcg ctacgaccgc gagcgcggca cggacctgct cgacagcctg 17281 gcccgctacc tcgccaccgg cgaggacgcc cgactggcgg cccgccaact gcacgtccac 17341 cccaacaccc tgcgctaccg cctgcgacgc gcacacgaga tcgcgggcct cgacctcacc 17401 gacccggccg ccaagttcga gatccagctc cgcctacgcc tacgagcgct gcgcctgccg 17461 tagctgacgc cgggcccata cgcatcctcc ggcccgccgc cgaattccgg cgcggccccg 17521 gcttctggcg tgccgccgac tttcggcgcg ctgccaacat ccagtgcgtc ccgtgggccc 17581 gttgacggcc gggagcctct gtggcgggcc gcggcgggtg gctttggcgg cgctgtcccg 17641 tgccgggcgt gctcgcgccg aatggccacg cgcccgggac gatgcccccg ccggggcgcc 17701 cccgccgaga cggctcagcc cgcgcccggg cggaccccca ccgggacggc cttcgccggg 17761 gatgggccct cgccgggacg cccccgcccg cacccggggg cgggcagcac cgggggccct 17821 gcctgcgcct gaggacggcc gtccgcccgg ggcggccctc cgccgggaac gccactcgcc 17881 gcggacgggc ccccgcccgg agcggcccgg cctcgggggc ggccagcgcc cgaggccggg 17941 ccggcaccac cgcccgcccg ccacgcgtcg tcggcttgtt ccgggagaca acacccgccc 18001 ccgcgcaatc ggtccccagg acagtgcggc gctcgccccc gcgcgcccat gatgcgtacg 18061 cagcacgcaa agccagcggg aaggggaacg tcaccgtgtc cacaccacgc agcgccgtcg 18121 tcgtcggtgc cggaatcgtc gggctcgcca ccgcgtgggc cctccagagc cggggcgtcg 18181 aggtcacggt ggccgagcgg cggcggcccg cggccggggc ctcgtggggg aacgcggggt 18241 ggctgacgcc ggcgctcgcc atgccgttgc ccgagcccgc cgcgctgcgg tacggggtgc 18301 gcagtctggt cacgccgacc tcgcccgtct acatcccgcc gcgggccgat ccgcgcctgg 18361 cgcgcttcct gctgtcgttc acccggcact gcacgccgcg ccgctggcgg gtgctggcca 18421 cgacgttcgc cgcgctgaat ttttttgcgc tcgccgcgta cnnnnnnnnn nnnnnnnnnn 18481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18721 nnnnnnnnnn nncgcggggg gaaggtcgtg gagcaggccg aagtatcggg catccgcgac 18781 ctgggcacgg gggtcgcggt cggtacgtcg cagggcgatc tgcgcgcgga cgtcgccgtc 18841 gtctccaccg ggacctggct gaaccggctg gtccgcccgt tcggggtgcg ggtgcccgtc 18901 cagtccgggc gcggctacag cttcagcgtg cccgccgcgg gcgcaccggc gcgcccgacg 18961 tatctggccg ggcagaaggt ggtgtgcacc ccgctgggcg acggccgggt gcgggtcgcc 19021 gggatgatgg aactggcgcc tccggagcgg ccggtcgatc cgcgccgcat ccaggcgatc 19081 atcgccgcgg cccgtccgct gctgcgggac gtcgactggg acgcccgccg ggacgagtgg 19141 gtcggctcgc gcccgtgcac cgccgacggg ctgccgctgg tcggcccgac cgcctcgccg 19201 cgggtgtacg tgaacggcgg ccacggcatg tggggcgtgg ccctcggccc cctcaccggt 19261 cggctgctgg ccgacgccat caccaccggc accgcacccg ccgaactggc cgcgctgcat 19321 cccctgcgct gaccgcgctg acgttttacg ggcgcgggcc cggttacccg gtgcggtgac 19381 agcgtcgaaa ggagtgaccg atgagcaccg tgcgggagac cgtcgaggtc gaggttccgc 19441 tgcacacggc ctacaaccag tggacgcagt tcaccgagtt cccgcggttc atggaaggcg 19501 tggaccaggt gacccaggtg gacgaccgtc acaaccactg gtcgacttcc atcgccggtg 19561 tgcaccgtga gttcgacacc gagatcgtcg atcagctccc cgacgagcgc atcgcctggc 19621 gtacgacctc gggcgaggtg cagcagcagg gcctggtgac cttccggtcc ctggacgcca 19681 cccacaccga ggtcaacctg gccatggtct tcgagccgag cggcatggcg gagaaggccg 19741 cggacatgac cgggacgctc gaccgccgga tcaagggcga tctgcaccgg ttcaaggact 19801 tcatcgagca ccggggccag gaagagggcg gctggcgcgg ccggatcagc cccggctgac 19861 cgccttcgct ccggaccgag ggcgtcggcc gactatccgg gtcggccgac gccctcgcgc 19921 gcgccgtgac ggagcctgag cccggctgcg gatacgccct tgcccggccg ccgtaccggg 19981 cgcaagctgg tcatatgggt actccaggag gccctacgct catcacctcc gtgcagcgag 20041 ccttccgcct gatggaggcc gtgggcgcac atgagggcgg tgcgccggcg aaacagctgg 20101 cgcgggaggc ggggctgccg ctggccaccg cgtaccacct gctgcggacc ctggtccacg 20161 acggctatgt gcaccggctg ccggacggcg gcttcgtcgt cggcgacaag ctgcatacgc 20221 tccaggtcgg cagccgcggg caggcgctgc tcaaccgggt gcggccgacg ctggccgggc 20281 tgcgggacac actgtcggcg gccgcgtatc tgaccttcta cgaggacggc gagatccggg 20341 tcgcggagat cgtcgacagc ccccgggcgc cccgggtgga tctgtgggtg gggttcgagg 20401 acgcagggca tgccaccgcg ctcggcaagt gtgtcctgcg cgagctgggc gacgaggccc 20461 gcagcgacta tctgtcccgg catccgctcg ccgacctcac gccccgcacc gtcacccgcc 20521 ccgccgagct gctgcggcgc ctggacgcct cggccgccgg tgagccggtc atcgacctgg 20581 aggagtacac gctgggcacg gtctgcttcg cggtgcccgt gtacagcggg gaccagctcg 20641 gatcgctcgg ggtgtcgctc caggcaggcc gggcgggtct ggccgggcag accgggcagg 20701 gagaccgggc cgcgcggctg gaggagatcc gcgagcggct gctgccgacg gccgaccgcg 20761 tgaccaggag cctttcgctc actatctgaa attccggccc ttgtcgctcc ccgcgaagcg 20821 ctggttctct ggatgaaacg gacatcacgc cgtatccgaa cgaacccggc gagcgagaga 20881 gagcagtcga cccggacatg atccaggccc gcaaccatct ggaccagccc tatccccccg 20941 cgccgttcgc ggccggagtg cccgtactca tcctgggtgc ggtcgcggtc atcgccttcg 21001 tcaccggaga cgggacgagc tggctgccgc tgctcgccgt cggccccgcg ctggccgccg 21061 ccgcgtgccg cccgtgggcg gtgctgcgga tcgggttcct cgccgtcgcg ctgggcgtgg 21121 ggctcggcgc gtggcaggcc gcgccggtcc acggacaggc ggtcgtgctg tcgacgctca 21181 tcgccgtgac cctggcgagc tgcctggcca gcgtgttgcg caggcgccgg gaacgggtgc 21241 tggccgcggt ccgctcggtc gccgaggccg cgcagaacgc gctgctccgg ccggtgcccg 21301 cgagggtcgg acagtttcag gtggcggtcc gctacagcgc cgccgcggcg gaggcccggg 21361 tgggcggcga cctgtacgcg ctggtgtcca ccccgtacgg ggtccggctg atcgtcggcg 21421 atgtgcgcgg caaggggctg cccgccgtgt ccaccgccgc gctggtcctc ggcgtgttcc 21481 gggaggccgc gtacgacgaa ccggatctgc tggacgtcgt cggccgcatc gagcgcagcc 21541 tcgcccgtaa cctcgccccc gatgacttcg tcaccgccgt cgtcgccgga taccccgccg 21601 acgggcgcat ggagatcgtc aactgcggtc acgcgccgcc gctgctgatc ggcccggccg 21661 gtgcggtcgt gcccgtcgag ccggtgcgcc cggcgccgcc gctgggcctg gcctcgctgg 21721 gcggggaggc gccgagcctg gaggtggtgc cgttcgccga cggcgaccag atgctgctgt 21781 acaccgacgg ggtcatcgag gcgcgcgatc acggccggtc gtacttcccg ctggccgagc 21841 gggtgcccgg gcacgtctcc gacgagccgt cccggaccct ggccgggctg cacgacgaac 21901 tgctggcgca cgtgggcggg cggctgcacg acgacgcggc gctcctgctg ctgcgcaagc 21961 ccgcctcggg ccgggtgggg caggcggtcg acgcggccgc cgacaccacg ggcgtctgag 22021 gggccaagag gcggcgcggc ccgccctagc cgaagtcggc gatcaattca tggaagagat 22081 cgtgcacggc atgggcgggc tccgacagcg gctgatggtc ggacgtacac aacgagagct 22141 tgaccgggat ggtcgggttc acgatccggc gcaccaccag gttctgcacg tcgaggatcg 22201 cgcgcgccgc cgaccacggc agcaccgtcg cgcccaggtc cgcgccgacc gcgctgacc //