LOCUS       NZ_GG657754            22065 bp    DNA     linear   CON 01-MAY-2024
DEFINITION  Streptomyces himastatinicus ATCC 53653 supercont1.1, whole genome
            shotgun sequence.
ACCESSION   NZ_GG657754
VERSION     NZ_GG657754.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces himastatinicus ATCC 53653
  ORGANISM  Streptomyces himastatinicus ATCC 53653
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
REFERENCE   1  (bases 1 to 10901646)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Annotation of Streptomyces hygroscopicus strain ATCC 53653
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10901646)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
REFERENCE   3  (bases 1 to 10901646)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Kodira,C.D., Zeng,Q.,
            Koehrsen,M., Alvarado,L., Berlin,A.M., Borenstein,D., Chen,Z.,
            Engels,R., Freedman,E., Gellesch,M., Goldberg,J., Griggs,A.,
            Gujja,S., Heiman,D.I., Hepburn,T.A., Howarth,C., Jen,D., Larson,L.,
            Lewis,B., Mehta,T., Park,D., Pearson,M., Roberts,A., Saif,S.,
            Shea,T.D., Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Galagan,J.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Arachne v. April 2007
            Genome Coverage                   :: 6x
            Sequencing Technology             :: ABI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000158915.1-RS_2024_05_01
            Annotation Date                   :: 05/01/2024 03:02:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,680
            CDSs (total)                      :: 9,608
            Genes (coding)                    :: 8,720
            CDSs (with protein)               :: 8,720
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 1 (5S, 16S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 888
            CDSs (without protein)            :: 888
            Pseudo Genes (ambiguous residues) :: 0 of 888
            Pseudo Genes (frameshifted)       :: 423 of 888
            Pseudo Genes (incomplete)         :: 530 of 888
            Pseudo Genes (internal stop)      :: 36 of 888
            Pseudo Genes (multiple problems)  :: 97 of 888
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:01:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 811851
            Orig. end                         :: 833916
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GG657754.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation was added to the scaffolds in August 2010.
FEATURES             Location/Qualifiers
     region          1..22065
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="5"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22065
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22065
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12065](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12065)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gap             154..460
                     /estimated_length=307
     gene            <461..789
                     /locus_tag="SSOG_RS02725"
                     /old_locus_tag="SSOG_00563"
     CDS             <465..789
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174678.1"
                     /locus_tag="SSOG_RS02725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00563"
                     /product="ATP-binding protein"
                     /protein_id="WP_039936400.1"
                     /transl_table=11
                     /translation="PPLPAPAARIADIALDNSAKFVPSGGTVTVSLDAAGALRIADDGP
                     GLAPEQLAAAPGRFWRAPDHGNVPGSGLGLAIAAELARSCGAELTLRSAEPRGLVVELR
                     LPVG"
     misc_feature    complement(506..521)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            complement(1142..2077)
                     /locus_tag="SSOG_RS02730"
                     /old_locus_tag="SSOG_00564"
     CDS             complement(1142..2077)
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174679.1"
                     /locus_tag="SSOG_RS02730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00564"
                     /product="TAXI family TRAP transporter solute-binding
                     subunit"
                     /protein_id="WP_009712674.1"
                     /transl_table=11
                     /translation="MHTVPRRLLLALAAGGLAGCSDPGPSAQVRLATGPRGGPYATFGS
                     RLATEAHRAHHGLTVRVLTTAASVENLRMLGDGRADLALTLADSAADAAAGHGIFPRKI
                     PVAALARLYLNYLHLVVPADSTIEHPAQLAGRTVSLGAAGSGTSTTAGRVLAAAAVRDV
                     RAVRLGLGASADALTDGEVDAFFWSGGAPTWAISRLARRRPLRLIPLGGLARALRRDHG
                     PVYEEVSVPAGAYGLKGPTPTVGTPSYLVCRSGLPDGTARALTDVLFERRDRLPVPDAP
                     GSRLDERYAIGTGTVPLHPGAAAYYRAAYG"
     gene            complement(2110..2532)
                     /locus_tag="SSOG_RS02735"
                     /old_locus_tag="SSOG_00565"
     CDS             complement(2110..2532)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174680.1"
                     /locus_tag="SSOG_RS02735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00565"
                     /product="ATP-binding protein"
                     /protein_id="WP_039936403.1"
                     /transl_table=11
                     /translation="MSSAGVDMALRQESLQLPARGASVAAARRLVRNRVPHWGFDEDVC
                     GAAELVMSELFTNALVHTASDQILCVLRAQERRSLYVEVADQGGGPLGPMPREAGVEDE
                     SGRGLALVRALTEAWGDRPGAAGGRVVWAQLGALAR"
     misc_feature    complement(2713..2725)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            2803..3660
                     /locus_tag="SSOG_RS02740"
                     /old_locus_tag="SSOG_00566"
     CDS             2803..3660
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712676.1"
                     /locus_tag="SSOG_RS02740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00566"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_009712676.1"
                     /transl_table=11
                     /translation="MGEARSAPTVGQMVLGMRLRHLREQAGVGYDAAAKALHVNQTTVR
                     RMEKAEVGLKLPYVEKLLRTYGVGQDEVESFLGLVEEANRPGWWHRFRDVLPDWFSLYV
                     SLEGAASRIRAYEPHFIPGLLQTEDYARALLRIGFPQGSEEELGRRVALRMERQELLSR
                     PGGPHLWAVMDETVLRLHIGGPKIMRAQIDRLIEAIQMPNVTLQVVPFAAGPHPGMGGP
                     FQLFRFQIPELPDIVYAEGLTGAGYLDQRTDVAAYLEALDQMGTRATSARRTEGFLREI
                     RKEL"
     gene            3663..3968
                     /locus_tag="SSOG_RS02745"
                     /old_locus_tag="SSOG_00567"
     CDS             3663..3968
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542876.1"
                     /locus_tag="SSOG_RS02745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00567"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_039936404.1"
                     /transl_table=11
                     /translation="MDQVEDVYNGMPATRLATEGWRKPWSGPNGGACVEALRLHDGRIA
                     LRQSTDPDGPALIYTHHEMEKFIQGAKAGAADFLLTRPDNNNLATSAANAPERRAA"
     gene            3965..4786
                     /locus_tag="SSOG_RS02750"
                     /old_locus_tag="SSOG_00568"
     CDS             3965..4786
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056915.1"
                     /locus_tag="SSOG_RS02750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00568"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_009712678.1"
                     /transl_table=11
                     /translation="MTDYGLAPDQQIDTSKPHSARMYDFYLNGKDHYEVDAEAAGKVLS
                     VYPTVKLNATVNRGFIHRATRWLAAEAGIRQFLDIGTGIPTEPNLHQVAQSVAPEARVV
                     YTDYDPIVLAYAQALLRGTPEGRTAYVQADVREPQRIISATELRETLDLSKPVAMSVNA
                     LFHFIPEEEKPYELVRELMGALAPGSYLMLTHSTADFHAETWQKVIAVYKESGISFVTR
                     SKSEVAAFFDGMELVDPGVSEPHDWKPDPGDRPDEIRSADINMWAGVARKP"
     gene            complement(4797..6197)
                     /locus_tag="SSOG_RS02755"
                     /old_locus_tag="SSOG_00569"
     CDS             complement(4797..6197)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056914.1"
                     /locus_tag="SSOG_RS02755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00569"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_009712679.1"
                     /transl_table=11
                     /translation="MRFPLRRHPRPSLRTTFALSFAAVASVVTLLVGFLSYDAAAGLVR
                     VDQKSAFTDVIRDLRTQVRGQKVILRQYPSEVPVPYGLRDDLRRISRMDVQVLGGRGGV
                     YDEGKPALPVGDEDRETAAAAAPGTMRQRNISIGEDDYRMATVALGDHRGAVQVAQQIS
                     DTEDLLRELQKRTALFVVAIIVAAGLAGWWLAGRITRRLTRLTRVAESVAVTGRMEVAV
                     PVAGDDEVGRLGRAFDGMLGRLARSKDDQRRLVQDAGHELRTPLTSLRTNISLLSRFEK
                     LPPAARDELLADLAGETRELTDLVNELVDLAAGQRDDEPRTEVSLDEVATKAATLARRR
                     TGRDITVRAKGDTLVEGHPAALLRAVSNLVENAAKFDRDGTGPVEVVVSGHRVEVRDRG
                     PGIAEEDRERVFDRFYRAPGARSLPGSGLGLAIVREVALAHGGTVFARPRPDGGAVLGF
                     TVDGPEEP"
     gene            complement(6201..6905)
                     /locus_tag="SSOG_RS02760"
                     /old_locus_tag="SSOG_00570"
     CDS             complement(6201..6905)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056913.1"
                     /locus_tag="SSOG_RS02760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00570"
                     /product="response regulator transcription factor"
                     /protein_id="WP_009712680.1"
                     /transl_table=11
                     /translation="MTNTVLLAEDDRAIRHALERALTLEGYRVTSVSDGVEALAAIHRE
                     HPDVIVLDVMMPGVDGIQVCRVLRAEGDRTPILMLTARVETADRIEGLDAGADDYVAKP
                     FDVEEVFARLRALLRRVAPVPEPTTEGTVFDATLAVADLRLDPSARRVWRGGTELELTR
                     TEFDLLELLARNAGIVLDHGTIYSRIWGYDFGPGSKNLAVYIGYLRRKVDQTGLTPLIH
                     TVRGVGYTLREE"
     misc_feature    7078..7093
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            7079..8344
                     /locus_tag="SSOG_RS02765"
                     /old_locus_tag="SSOG_00571"
     CDS             7079..8344
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056912.1"
                     /locus_tag="SSOG_RS02765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00571"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_039936407.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 4.8e-39,
                     bitscore: 132.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVFLLHNAYGIGGTIRTTLNLAAALAERHEVEIVSMMRHRGKP
                     RFTLDPRVRLVPLVDTRPGGLDARDPLFAERTRDFPVHEKRNHQYNRLMDVRIARYLEG
                     SDADVIIGTRPGVNVYLARFGPRKALRIAQEHLRYEAHSKKLRAELAPYYRELDAVVTT
                     TEADAAVYRAKMPLPGAWTLAIPNSVPEPAAPPSEGTTPVIAAAGRLVRGKRFDLLIDA
                     FAEVSPKHPEWRLRIYGGGSQKDRLQERIEELGLTASAELMGPYSPIEEEFAKASIVAV
                     ASDAESFGMTIVEAMRCGVPVVSTDCPLGPAEIIEDGVTGRLIPVGDKQAMAQALRDLI
                     DDEPGRRAMAAAALESARMYDPEPIAMRYEQLFEELASSRFARKWERTRVRLRASYRRK
                     VRRWKRAFRRRLPAAGGTSAKA"
     misc_feature    7080..7094
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            complement(8391..9881)
                     /locus_tag="SSOG_RS02770"
                     /old_locus_tag="SSOG_00572"
     CDS             complement(8391..9881)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056911.1"
                     /locus_tag="SSOG_RS02770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00572"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_009712682.1"
                     /transl_table=11
                     /translation="MEAGRPGAEYPGAEAPGTDEPGIDPERLATCLSVLEELDRLPIDH
                     PDAITVRRATAGIYRTVKQRRRSERRAAKTANDKAVTEATATGAADRIDDETLGRALSS
                     SVTSEIAGILERPRSCYVCKTRYVEVDAFYHQLCRGCAAENRARRDARTDLTGRRALLT
                     GGRAKIGMYIALRLLRDGAHTTVTTRFPNDAIRRFTAMPDSAEWLHRLKIVGIDLRDPA
                     QVIALTDEVSAAGPLDILINNAAQTVRRSPQAYGELIAGESAPLPAGELPEAVVLGAFG
                     SGSQTALPGPRRERDGALTAQDLTALALTSGSASPARIEAGTAIDAGGLVPDLDPTNTW
                     IQRVHEVDPVEMLEVQLCNETAPFILVSRLRPAMAAAPARRKYVVNVSAMEGKFGRGYK
                     GAGHPHTNMAKAALNMLTRTSAREMFESDAILMTAVDTGWITDERPHPDKMRLAADGFH
                     APLDLVDGAARVYDPIVRGEQGEDLFGCFLKDYAPTTW"
     gene            complement(10001..11107)
                     /gene="pqqE"
                     /locus_tag="SSOG_RS02775"
                     /old_locus_tag="SSOG_00573"
     CDS             complement(10001..11107)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174692.1"
                     /locus_tag="SSOG_RS02775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00573"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_039936410.1"
                     /sec_met_domain="PF04055 (E-value: 6.3e-24, bitscore: 84.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.5e-06, bitscore: 26.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.5e-06, bitscore: 27.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.9e-09, bitscore:
                     35.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHPQGHPRPWALLAELTHGCPLHCPYCSNPLQLTRRSRELTGE
                     EWERVLRQAAELGVVHTHLSGGEPLLRRDLEVIVAAAASAGLYTQLVTSGVGLDEARLT
                     ALTGAGLHSVQLSVQHADPGASDRIAGHRSFAAKERAAALVREAGLPLGVNVVLHRDNL
                     DALDPLIELAVAWGADRVELANTQFYGWALRNRAALLPTREQLARAREGVARWREKLGG
                     RTELVWVLPDYFEGVAKPCMGGWGAVSLTVAPDGTVLPCPAAAALPGLDPPNVRDHALE
                     WIWDHSAAFNRYRGEEWMAEPCRSCSHRAEDFGGCRCQAYALTGDAARTDPACALSPDH
                     GLIRSLTGPAPAAEPPPPGYTYRGYGRG"
     gene            complement(11104..11370)
                     /gene="pqqD"
                     /locus_tag="SSOG_RS02780"
                     /old_locus_tag="SSOG_00574"
     CDS             complement(11104..11370)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433952.1"
                     /locus_tag="SSOG_RS02780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00574"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_039936411.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.9e-19, bitscore:
                     67.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-12, bitscore: 45.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPAAWRPALAPAVHLRHDRVREVDLLVMPERVVVLRGTAGTVL
                     RLCDGGRDLDTIVAELAERFPGAPVATDVPAFLDRMHEEGWIR"
     aSDomain        complement(11110..11349)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SSOG_RS02780_PqqD_RRE.1"
                     /evalue="1.20E-21"
                     /identifier="RREFam006.1"
                     /label="SSOG_RS02780"
                     /locus_tag="SSOG_RS02780"
                     /protein_end="87"
                     /protein_start="7"
                     /score="67.3"
                     /tool="antismash"
                     /translation="RPALAPAVHLRHDRVREVDLLVMPERVVVLRGTAGTVLRLCDGGR
                     DLDTIVAELAERFPGAPVATDVPAFLDRMHEEGWI"
     gene            complement(11367..12065)
                     /gene="pqqC"
                     /locus_tag="SSOG_RS02785"
                     /old_locus_tag="SSOG_00575"
     CDS             complement(11367..12065)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="SSOG_RS02785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00575"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_009712685.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.4e-81, bitscore:
                     271.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSLEERLRAVAQERYHDRHPFNLRMHAGELTPAELRRWILNRF
                     HYQRHIPVKDALITAKLDTPRLRRMWLRRIQDHDGAADGEGGIERWLRLGEAAGIGRER
                     LLTGAEVLPGVRLAVDGYVNFCRLGTPLEAVAASLTELSAPGIMRTRIEAFEHHYPWIE
                     REGLRYFRDRVGQGSRDSAEALDLVLTWACTPEDEERAVAALTFKCDVLWSLLDAVDHA
                     DTKDTAGEGI"
     CDS             complement(12062..>12521)
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056907.1"
                     /locus_tag="SSOG_RS02790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00576"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_009712686.1"
                     /transl_table=11
                     /translation="DADFAIAAVPVSAKRPRYAAELDGPDEDDWVVALHLRDRATGRSL
                     LYAPALAAWSDAFQRAAEEADCVIVDGTFWDDEEPLRSGFGSRTATAMGHVPIDGPGGT
                     AGRLAALGARTLYTHLNNTNPLNDPAAPQHAVLAGRGIEVAADGMVIEL"
     gene            complement(12062..>12525)
                     /locus_tag="SSOG_RS02790"
                     /old_locus_tag="SSOG_00576"
     gap             12526..12863
                     /estimated_length=338
     gene            complement(<12864..12956)
                     /locus_tag="SSOG_RS55550"
                     /pseudo=""
     CDS             complement(<12864..12956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079182.1"
                     /locus_tag="SSOG_RS55550"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRVRVLGTAAGGGVPQWNCACPGCSGGTRPP"
     gene            complement(12968..13111)
                     /gene="pqqA"
                     /locus_tag="SSOG_RS02795"
                     /old_locus_tag="SSOG_00577"
     CDS             complement(12968..13111)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_093467075.1"
                     /locus_tag="SSOG_RS02795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00577"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_009712687.1"
                     /transl_table=11
                     /translation="MNETVRQTAPEAVDHTRTPAPETAWQTPDYVVVETALEVTAYSLN
                     AR"
     gene            complement(13175..14677)
                     /locus_tag="SSOG_RS02800"
                     /old_locus_tag="SSOG_00578"
     CDS             complement(13175..14677)
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012516.4"
                     /locus_tag="SSOG_RS02800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00578"
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_009712688.1"
                     /transl_table=11
                     /translation="MTRSTRLRTAVITAAAACLLAVAPQTATAQPGAADRTYDVRDYGA
                     TGDGTTLDDDAIDRAIDAAAAAPGRGTVLFPPGTYKSRTLHLKSDITLHLAKGATLLAA
                     AGGMDEAEPNPWDAYQDFGHSHFRNALLTGENIHHLAITGSGTLDGEGLGTSNTLEPGV
                     GDKILSLKRCADLDIQDVTFTRGGHFALLLNGCDGVRMTRTKVLTSTDRDAVNLINSRH
                     VDIGQSRIEGRDDGVVLKSDYALGRTYTSQDVRVHDSDVLSTENNALQFGSETCGDFRD
                     IRFDRLRIGGGGKAAIGIVSMDGADISDVRYSDITMTKGATPVFIKIGDRKRCPGAPPA
                     GRIHDIRFRNVTGTGLTHPVTGVDYTSTITGAPGADVEDITFDRVRLTVPGGHPASDAE
                     LVPGEFLTDYVPKTYGVRPSYGWWIRHAKGITFTNSAVTTDTNDDRPAFIADDGVGITL
                     DRVTAGRGTASPYDVGFSGVTGPVVRHSTTTDGEALRIRTTG"
     misc_feature    complement(14657..14659)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14674..16464)
                     /locus_tag="SSOG_RS02805"
                     /old_locus_tag="SSOG_00579"
     CDS             complement(14674..16464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056904.1"
                     /locus_tag="SSOG_RS02805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00579"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_039940546.1"
                     /transl_table=11
                     /translation="MGRSSRRLGAWLAAVLLAIGTLALAGPVPARAEVVNPRQQWLRDS
                     QAGLFLHWGMRTSPGYTSCAAWEKAVTDGGWSAGYWVDEAKKLHAKYLVLASFHSRLGY
                     ARAWPSAIPGSCSTKRDFLGELVDAAGKQGLKVMLYMTDDPQWHDEGGHEWLDSAAYSA
                     SKGRDVDLTTRDGFGEYSYDNFVEVMKKYPKLSGFWIDNDNDYWLDHGLYEKIRADRPS
                     WLLSNNNEDTPIMDTVSNEQKTGMTPAYDYPQAIWTPQPRLTEACFKLPSSGAWWYSGT
                     DSAVDHGLTLGRLISNSGSSVKSLMAETAQVNGKFPSKQEAFNNAAKTYLDKIWGSLDG
                     TEGGGYAYGGLQPGSWNDGARGVTTVSRTDPDQHYLHVLTKPSGSTLTVRDNGYRVSGV
                     TDFRTGRKLAFSQGEGKLTVSGISGWDPYDTVLSVRTDGRQGLIPADSMTASASASASG
                     HPASAVLDGDPQTYWDNNTKLPATVTFDLRSARSVRYLAVNQREWSVSYARSDTEQSAR
                     IRDYQVQVSGDGSTWGSPVKAGTLPSARGVQFIDLPATTKRFVRLTVNSTWAAATDTKR
                     YQKLLIDEVRIGSGYPKGDS"
     gene            16763..17569
                     /locus_tag="SSOG_RS02810"
                     /old_locus_tag="SSOG_00580"
     CDS             16763..17569
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056901.1"
                     /locus_tag="SSOG_RS02810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00580"
                     /product="hypothetical protein"
                     /protein_id="WP_039936412.1"
                     /transl_table=11
                     /translation="MERPPLLPRTALTLAATAALIAPAAVAYGTERSPQAPAASWSLKW
                     NPASGASVASAFEGAEDDRADSHPGTTHIYPSQGGFRTDMHYPRDVDTSTDRQRNEVRG
                     MKQDGSAVKILKNETWRIQYQMYVPDTLDATTSFTHIMQIKVGDVAAPLFTMSLHQHDN
                     GPKVEIRTSDDDDNLTEAGAANMAPLQGAWSDVSVEVKAADSGAYADWSVTTGGKEVAS
                     YKRTGLDLWRGKNYLRPKWGIYRSLNSSGLQTTYLLTRNFKAYKLQ"
     misc_feature    16781..16783
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17581..18663
                     /locus_tag="SSOG_RS02815"
                     /old_locus_tag="SSOG_00581"
     CDS             17581..18663
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="SSOG_RS02815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00581"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_009712691.1"
                     /transl_table=11
                     /translation="MKSCRNTLVAAAATTALTAGLLLTQAGTGNAAPAAADSVPSAIST
                     VSSGWSIPWGLSWLPDGSALISERDSFKLFKLTQSGAKTQVGTVPNVVTTSGEGGLMGL
                     AVSPNWNTDHYVYIMHTASDGNRIARMTYDGSSLSGYKAIVTGIKKNKYHNGGRLKFGP
                     DGYLYATTGDAQTSSNAQDKNSLNGKILRMTTDGKAAPGNPFGTLVYSLGHRNPQGLTW
                     DAQGRLWEAELGNSTYDELNLIEAGKNYGWPTCEGSCSTSGMTNPKRQWTVGEASPSGV
                     TYADGALYMAALRGERLWRIPVDGTSAGTPKAYYTSSYGRLRTVETVPGKNTLWLSTTN
                     ADNNGGEADGADKVFQVELK"
     gene            complement(18720..19871)
                     /locus_tag="SSOG_RS02820"
                     /old_locus_tag="SSOG_00582"
     CDS             complement(18720..19871)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174701.1"
                     /locus_tag="SSOG_RS02820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00582"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_009712692.1"
                     /transl_table=11
                     /translation="MIRRRTVLASALGIGGGLLLPGTGVAHAAARTDWSRAVVDSTVAR
                     YPDPASLGGWGYTRGLFLLGAYRVYQRVGEPSYLAYIKRWVDNFVDADGHMSRTFDNLD
                     AMQSGNLLLMLHRETGDARYRTAADQIRARFADYPRTADGGMWHATGKTNELWGDGVFM
                     AQPFLLRYGIAYGDKSYAYDEVTRNLAVYFRHLKASNGLIYHAYDADGDAPWNPDDATG
                     TSAHFWARAIGWTAMTHIEVLEMLPARHPRRAELIANVRHLAKGFLRYQDRATGRWFQV
                     VDKPGEPGNWTETSASSMYTLMLHAALDHGWIRGGDYAAAARRGYRGVLDKVTVDADGL
                     TSIADISEGTNVGDLAYYLGRKRNTNDLHGLGAFLLMNERLAY"
     gene            complement(19888..20925)
                     /locus_tag="SSOG_RS02825"
                     /old_locus_tag="SSOG_00583"
     CDS             complement(19888..20925)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013434.4"
                     /locus_tag="SSOG_RS02825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSOG_00583"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_078510228.1"
                     /sec_met_domain="DAO (E-value: 1.5e-45, bitscore: 155.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRPAPNWCASSSASGCAPPHATTTAARARSARSSKGTFELFEEL
                     EALGVDGQAHKDGFLFAFPSRAYAAKALTAFRRLGAPIAAGGVLTGDALADTEPALTEG
                     ARAGFVVDDQWSLDPGLFVDRLAERLRRQGVELVEGARVSAVSERAGRAEVRTSAGTYR
                     SDAVVVAAGIWSRELVRGLGVDLDLVAGKGYSFSVAAEPPPSRLVHLGAAKVVLTPMGK
                     RVRVAGTMEFERDPDRFRRRRVEAIVAAARPYLRHADWDDLQEEWVGPRPMTPDGLPLI
                     GRVPGHSRVLLATGHNMLGLMLAPATGRLVAGLLTGDADPALSSRFDPVRCARRYPWRV
                     HGILN"
     misc_feature    21586..21595
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    21732..21746
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
ORIGIN
        1 ggatggacgc ccgggtacgc gacggcggcc acgggcccgc cgagctgcgg ctgctggaac
       61 ggcggttcaa cgccatggcc gacgcggtct ccaccgccct ggagcggcag cgcgccttcg
      121 tcgcggacgc ctcgcacgaa ctgcgcaccc cgcnnnnnnn nnnnnnnnnn nnnnnnnnnn
      181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ccccgccgct gcccgcaccg
      481 gccgcccgga tcgcggacat cgcgctcgac aactcggcca agttcgtgcc gtccggcggc
      541 acggtcaccg tctcgctcga cgccgccgga gcgctgcgga tcgccgacga cggccccggg
      601 ctcgcccccg aacagctggc cgcggccccc ggccgcttct ggcgcgcccc ggaccacggg
      661 aacgtccccg gcagcggcct gggcctggcc atcgccgccg aactggcccg ctcctgcggc
      721 gccgagctga ccctgcgctc cgccgagcca cgcggcctgg tggtggagct gcgcctgccg
      781 gtgggctagg gcgggttcct ctcccccacc ccgccgcttc ccgaaacggg ggacaccccc
      841 gcccccggga ggtccacccc gacggtgcgg aaggcgttgg cgcgggcagg gcgcgcgcac
      901 tgcggggccg ccgcgtaccc gccggggagg cgagccgctg cctccacgcc ccttcgcgca
      961 cgccggatgc gcaccgcggc agcggcagcg ggcagcggca gcggcagcgg cagcggcagc
     1021 ggcagcggca ggcgaacgtg cagcccaggg gctccgccgt gcgggccacc gcgctccgcg
     1081 gcacccggcg cgcccggcgc cgcttcggca gcggggtcgg agcccgcggc gggccggggc
     1141 gtcagccgta ggcggcgcgg tagtaggcgg cggcgcccgg gtggaggggg acggtgccgg
     1201 tgccgatggc gtaccgctcg tccaggcggc tgcccggcgc gtccggcacc ggcagccggt
     1261 cgcggcgctc gaagagcaca tcggtgagcg cgcgggccgt accgtcgggg agcccggagc
     1321 ggcagacgag atagctgggc gtgcccacgg tgggggtcgg ccccttcagc ccgtacgccc
     1381 cggccgggac ggagacctcc tcgtagaccg ggccgtggtc gcggcgcagc gcgcgggcga
     1441 gcccgccgag ggggatcagg cggagcgggc ggcggcgggc gagccgggag atggcccagg
     1501 tgggggcgcc gccggaccag aagaaggcgt ccacttcccc gtcggtgagc gcgtcggcgg
     1561 aggcgccgag cccgaggcgt acggcgcgga cgtcgcgtac cgcggcggcg gcgagcaccc
     1621 gtccggcggt cgtcgaggtt ccggacccgg cggcgccgag ggagaccgtg cgcccggcca
     1681 gctgggcggg gtgctcgatc gtggagtcgg cgggcacgac caggtgcaga tagttgaggt
     1741 acagccgggc gagggccgcg accgggatct tcctcgggaa gatgccgtgc cccgcggcgg
     1801 cgtccgccgc gctgtcggcg agggtgagcg cgaggtcggc ccggccgtcg ccgagcatgc
     1861 gcaggttctc cacgctcgcc gcggtggtga gcacccgcac ggtgagcccg tggtgggcgc
     1921 ggtgcgcctc ggtggccagt cggctgccga aggtggcgta ggggccaccc cgcgggccgg
     1981 tggccagccg cacctgggcg gagggcccgg ggtccgaaca accggcgagc ccgcccgcgg
     2041 cgagcgccag cagcaggcgg cgtgggacgg tgtgcacccg gcgatgctaa ccgccggggt
     2101 ccgtactggt cagcgggcca gcgcgccgag ctgggcccac accacgcggc cgcccgccgc
     2161 ccccggccgg tcgccccagg cctcggtcag ggcgcggacg agggccagac cgcggccgct
     2221 ctcgtcctcc acacccgcct cccggggcat ggggccgagc gggccgccgc cctggtcggc
     2281 gacctcgacg tacagcgagc gccgctcctg ggcgcggagc acgcagagga tctggtcgct
     2341 cgcggtgtgc acgagcgcgt tcgtgaacag ctcggacatc accagctcgg ccgcgccgca
     2401 cacgtcctcg tcgaagcccc agtggggcac ccggttccgg acgagccgtc gcgcggcggc
     2461 gaccgaggca ccccgggcgg gcagttgcag actctcctgg cggagggcca tatcaacgcc
     2521 ggcggagctc atgtgagggg ccatcgtcga gcgttgacgc aatgccacgg ccatgtgcct
     2581 tccgtccgtc tacctgtggg ggcgtgaacg ccgcccgtac gcgactgccg caagtgcgcg
     2641 acagggcagc cacgttggga ccggtcacga cgccactatc gttcctgcga gcatcagttg
     2701 gcaaggcgcg ttctgcaaaa tgcagaatgt ccacggcagt ctgtgccgct cacaccgagc
     2761 atggcacact gagacgcaca acaccgtcgg aggaggtatg acgtgggtga agcgcggtct
     2821 gccccgaccg tcgggcagat ggtcctcggc atgcggctgc ggcacctccg cgagcaggcc
     2881 ggcgtcggtt atgacgcggc cgccaaggcg ctgcatgtca accagaccac cgtgcgccgg
     2941 atggagaagg ccgaggtcgg cctgaagctc ccgtacgtcg agaagctcct gcggacgtac
     3001 ggcgtcggac aggacgaggt ggagtccttc ctcgggctcg tcgaggaggc caacaggcct
     3061 ggctggtggc accggttccg cgatgtgctg cccgactggt tcagcctcta tgtgagcctg
     3121 gagggcgccg ccagccgcat ccgcgcgtac gaaccgcact tcatccccgg tctgctccag
     3181 acggaggact acgcccgcgc gctgctgcgc atcggcttcc cgcagggctc cgaggaggag
     3241 ctgggccggc gggtcgccct gcggatggag cgtcaggagc tgctctccag acccggcggg
     3301 ccgcatctgt gggccgtcat ggacgagacg gtgctccgtc tgcacatcgg cgggccgaag
     3361 atcatgcgcg cccagatcga ccgcctcatc gaggccatcc agatgccgaa cgtgaccctc
     3421 caggtggtgc cgttcgccgc cgggccgcat ccgggcatgg gtggcccctt ccagctgttc
     3481 cggttccaga tcccggaact gccggacatc gtctacgccg agggcctgac cggcgccggc
     3541 tatctcgacc agcgcaccga tgtggccgcc tatctggagg cactggacca gatgggcacc
     3601 cgggccacat cggcgcggcg cacggagggc tttctccgag agattcgcaa ggagctgtga
     3661 ctgtggatca ggtagaagac gtctacaacg gcatgcccgc cacccgtctg gcgacggaag
     3721 gctggcgcaa gccctggagc ggccccaacg gcggtgcgtg cgtggaggcc ctgaggctgc
     3781 acgacgggcg gatcgccctg cggcagtcga cggaccccga cggccccgcg ctgatctaca
     3841 cccaccatga gatggagaag ttcatccagg gcgccaaggc cggtgccgcg gatttccttc
     3901 tcacccgacc cgacaacaac aacctggcca cctcggcggc taacgcaccg gaacggaggg
     3961 cggcgtgacc gactacggac tcgccccgga ccagcagatc gacaccagca agccgcactc
     4021 ggctcggatg tacgacttct acctcaacgg caaggaccac tacgaggtcg acgcggaagc
     4081 cgcgggcaag gtgctgtcgg tctacccgac cgtcaagctc aacgccaccg tcaaccgcgg
     4141 cttcatccac cgggcgacgc gctggctggc ggccgaggcg ggcatccggc agttcctgga
     4201 catcggcacc ggcatcccca ccgagccgaa tctgcaccag gtcgcccaga gcgtggcccc
     4261 ggaggcccgg gtcgtctaca ccgactacga ccccatcgtg ctcgcgtacg cccaggccct
     4321 gctgcgcggc acccccgagg gccgcaccgc gtacgtccag gccgatgtgc gcgaaccgca
     4381 gcggatcatc tcggcgaccg agctgcggga gacgctggac ctgagcaagc cggtcgcgat
     4441 gtcggtcaac gcgctcttcc acttcattcc ggaggaggag aagccgtacg agctggtgcg
     4501 tgagctgatg ggcgcgctcg ccccgggcag ctatctgatg ctgacgcact ccacggccga
     4561 cttccacgcg gagacgtggc agaaggtgat cgccgtctac aaggagagcg gcatatcctt
     4621 cgtcacccgc agcaagagcg aggtcgcggc gttcttcgac ggcatggagc tggtcgaccc
     4681 gggcgtctcg gagccgcacg actggaagcc ggaccccggc gaccgcccgg acgagatccg
     4741 cagcgcggac atcaacatgt gggccggagt ggcccgcaag ccgtagccga agaagactac
     4801 ggctcctcgg ggccgtccac ggtgaagccg aggaccgcgc cgccatcggg gcgggggcgg
     4861 gcgaagaccg tgccgccgtg cgcgagggcc acctcgcgca cgatggcaag acccagcccg
     4921 gaaccgggca ggctgcgggc gccgggggcg cggtagaagc ggtcgaagac ccgctcgcgg
     4981 tcctcctccg cgatgccggg gccccggtcg cgtacctcga cgcggtgccc gctcaccacg
     5041 acctcgacgg gcccggtgcc gtcccggtcg aacttggcgg cgttctccac caggttggag
     5101 accgcgcgca gcagggcggc cggatggccc tcgacgaggg tgtcgccctt ggcccgcacc
     5161 gtgatgtcgc ggccggtgcg ccggcgggcg agggtcgcgg ccttggtggc gacctcgtcc
     5221 agggacacct ccgtgcgcgg ttcgtcgtcc cgctgaccgg ccgccaggtc caccagctca
     5281 ttgacgaggt cggtcagttc ccgggtctcc cccgccagat cggccagcag ctcgtcgcgc
     5341 gcggcgggcg gcagcttctc gaagcggctc agcagcgaga tgttggtgcg cagcgaggtg
     5401 agcggggtgc gcagttcgtg tccggcgtcc tggacgaggc gccgctggtc gtccttggag
     5461 cgggcgagcc gcccgagcat gccgtcgaac gcccggccca gccgtcccac ttcgtcgtcc
     5521 ccggcgaccg ggaccgccac ctccatccgg ccggtgaccg ccacgctctc ggcgacccgg
     5581 gtgagccggg tgagccgccg ggtgatgcgt ccggcgagcc accacccggc cagtccggcg
     5641 gccacgatga tcgcgacgac gaacagcgcg gtgcgcttct ggagttcgcg cagcagatcc
     5701 tcggtgtcgc tgatctgctg ggccacctgt acggcgccgc ggtggtcgcc gagcgcgacg
     5761 gtggccatcc ggtagtcgtc ctcgccgatg gagatgttgc gctgccgcat ggtgcccggg
     5821 gcggcggccg cggcggtctc ccggtcctcg tcgccgaccg gcagcgcggg cttgccctcg
     5881 tcgtagacgc cgccccggcc gcccagcacc tggacgtcca tgcggctgat ccggcgcagg
     5941 tcgtcgcgca gcccgtaggg caccgggacc tcggaggggt actgccgcag gatcactttc
     6001 tggccacgca cctgggtccg cagatcgcgg atgacgtcgg tgaacgcgga cttctggtcg
     6061 acccgcacca gcccggccgc ggcgtcgtag ctgaggaagc ccaccaggag ggtcaccacg
     6121 gacgccaccg ccgcgaagga cagcgcgaag gtggtgcgca ggctgggccg tggatgacgg
     6181 cggagtggga agcgcaccgt tcactcctcc cgcagggtgt agccgacgcc gcgcaccgtg
     6241 tggatgagcg gggtgagccc ggtctggtcg accttgcggc gcaaataacc gatgtatacg
     6301 gccaggttct tcgatccggg gccgaagtca tagccccaga tgcgagagta gatcgtgcca
     6361 tgatcaagaa cgatgcccgc gttacgggcc agcagctcca gcaggtcgaa ttcggtgcgg
     6421 gtcagctcca gttcggtacc tccccgccac acccggcgcg ccgagggatc gagccgcaga
     6481 tcggcgaccg ccagcgtggc gtcgaagacg gtgccctccg tcgtgggctc cggtacgggg
     6541 gcgacgcggc gcagcagcgc gcgcagccgg gcgaagacct cctcgacgtc gaacggcttg
     6601 gccacatagt cgtcggcgcc cgcgtccagt ccctcgatcc ggtcggcggt ctccacccgc
     6661 gcggtgagca tgaggatggg ggtgcggtcg ccctcggcgc gcagcacccg gcacacctgg
     6721 attccgtcca ctcccggcat catcacgtcc agcacgatca cgtccgggtg ctcacggtgg
     6781 atggccgcca gggcctcgac gccgtcggac accgaggtca cccggtatcc ctccagcgtc
     6841 agggcgcgct ccagcgcatg gcggatggca cggtcgtcct cggcgagcag cacggtgttg
     6901 gtcacaggac gagtctgcca aggcccgtcg gatgcggtcc cccgcagccc cccggagctg
     6961 cggttcttac ccggctctca ccgtatccac gcgaccggct taccgagccg gtccagggta
     7021 cccagtacgt tccgggggga tcgcgccccg gtgttgccac cggccggaga gacaccgaat
     7081 gaagatcgta ttcctgctgc acaacgctta tgggatcggc ggaacgatac gcaccacgct
     7141 gaacctcgcc gcggcgctgg cggagcggca cgaggtggag atcgtctcga tgatgcgcca
     7201 ccgggggaag ccgcgcttca cgctcgaccc gcgggtgcgg ctggtgccgc tggtcgacac
     7261 ccggcccggc ggcctggacg cgcgggatcc gctgttcgcg gagcgcaccc gggactttcc
     7321 cgtccacgag aagcggaacc accagtacaa ccggctgatg gacgtgcgga tcgcccgcta
     7381 cctggagggc tccgacgccg acgtgatcat cggcacccgg ccgggcgtca atgtgtacct
     7441 cgcccgcttc ggcccgcgca aggccctgcg catcgcgcag gagcatctgc ggtacgaggc
     7501 gcacagcaag aagctgcggg ccgagctggc gccgtactac cgcgagctgg acgccgtcgt
     7561 caccacgacg gaggcggacg cggcggtgta ccgggcgaag atgccgctgc cgggggcgtg
     7621 gaccctcgcg ataccgaaca gcgttcccga gcccgccgcc ccgccctccg agggcaccac
     7681 gccggtgatc gcggcggccg ggcggctggt ccgcggcaag cgcttcgacc tgctgataga
     7741 cgccttcgcc gaggtctcgc ccaagcatcc ggagtggcgg ctgcggatct acggcggtgg
     7801 ttcccagaag gaccggctcc aggagcgcat cgaggagctg gggctgaccg cgagcgccga
     7861 gctgatgggg ccgtactcgc cgatcgagga ggagttcgcg aaggcgtcga tcgtcgcggt
     7921 cgcctcggac gccgagtcgt tcgggatgac gatcgtggag gccatgcgct gcggggtgcc
     7981 ggtggtgagc acggactgcc cgctgggccc ggccgagatc atcgaggacg gggtcacggg
     8041 tcgcctcata ccggtcggcg acaagcaggc gatggcgcag gcgctgcggg atctgatcga
     8101 tgacgagccg gggcgccgcg cgatggccgc ggcggcgctg gagagcgccc ggatgtacga
     8161 cccggagccg atcgccatgc gctacgagca gctcttcgag gagctggcgt cgagccggtt
     8221 cgcgcgcaaa tgggagcgca cccgggtccg gctgcgggcg agctaccgcc gtaaggtccg
     8281 ccgctggaag cgcgccttcc gccgccgtct gcccgcggcg ggcgggacga gcgccaaggc
     8341 gtgacgcccc ctgggccggg cggtgtccgc cgcccggcct gcccgccgga ttaccaggtg
     8401 gtcggcgcgt agtccttcag gaagcagccg aacaggtcct cgccctgctc accccggacg
     8461 atcgggtcgt agacccgggc cgcgccgtcc accaggtcca gcggggcgtg gaagccgtcg
     8521 gccgcgagcc gcatcttgtc cgggtgcggg cgctcgtcgg tgatccatcc ggtgtcgacg
     8581 gccgtcatga ggatggcgtc gctctcgaac atctcacggg cgctggtgcg ggtgagcatg
     8641 ttgagcgcgg ccttggccat gttggtgtgc ggatggcccg cgcccttgta gccgcggccg
     8701 aatttgccct ccatcgcgga gacgttgacc acgtacttcc gccgggcggg cgcggcggcc
     8761 atcgccgggc gcagccggct gaccaggatg aagggcgccg tctcgttgca cagctgcacc
     8821 tccagcatct cgaccgggtc cacctcgtgg acccgctgga tccaggtgtt ggtggggtcc
     8881 aggtccggga cgagcccgcc cgcgtcgatc gcggtgcccg cctcgatccg ggcgggcgag
     8941 gcggagccgc tggtgagggc gagggcggtg aggtcctggg cggtcagcgc gccgtcccgc
     9001 tcccgtcgcg gcccgggcag cgcggtctgg gagccgctgc cgaaggcgcc gaggacgacg
     9061 gcctcgggca gctccccggc gggcagcggc gccgactcgc ccgctatcag ctccccgtac
     9121 gcctgcgggc tgcggcgcac ggtctgcgcg gcgttgttga tcaggatgtc cagcggcccg
     9181 gcggcgctga cctcgtcggt cagcgcgatg acctgggcgg ggtcgcgcag atcgatgccg
     9241 acgatcttca gccggtggag ccactcggcg ctgtccggca tcgccgtgaa gcggcggatc
     9301 gcgtcgttgg ggaaacgggt ggtgacggtg gtgtgggcgc cgtcacgcag tagccgcagg
     9361 gcgatgtaca tgccgatctt ggcgcggccg ccggtgagca gcgcccggcg gccggtgagg
     9421 tcggtgcggg cgtcgcggcg ggcccggttc tcggcggcgc agccgcggca gagctggtgg
     9481 tagaacgcgt cgacctcgac gtaccgggtc ttgcacacgt agcaggagcg cgggcgctcc
     9541 aggatgcccg cgatctcgct ggtgaccgag gagctgaggg cccggcccag cgtctcgtcg
     9601 tcgatgcggt cggcggcgcc ggtggcggtg gcctcggtca ccgccttgtc gttggcggtc
     9661 ttggcggccc ggcgttccga gcgcctgcgc tgcttcacgg tgcggtagat accggcggtg
     9721 gcccggcgca ccgtgatggc gtcggggtgg tcgatgggca gccggtccag ctcctcgagg
     9781 acgctcaggc aggtcgccag gcgctcgggg tcgataccgg gctcgtcggt accgggcgcc
     9841 tcggcccccg ggtactcggc ccccggccgc ccggcctcca tccgctgggc ccggccgtcg
     9901 tcagtcaccg tcatcgccgc tgccgctttc tggttctgtt ctccctggtt aacggccgaa
     9961 ctttacggaa gcggggacgg ttgagccaaa ccgggcggcc tcaccccctc ccgtacccgc
    10021 ggtacgtata gcccggaggc gggggctccg cggccggagc ggggccggtc agcgaacgga
    10081 tcaggccatg atcgggcgag agggcgcagg ccgggtcggt gcgggcggcg tccccggtga
    10141 gggcgtacgc ctggcagcgg cagccgccga agtcctcggc gcggtgggag cagctacgac
    10201 acggttcggc catccactcc tcgccgcggt agcggttgaa ggcggcggag tggtcccaga
    10261 tccactccag ggcgtggtcg cggacgttcg gcgggtcgag gccgggcagg gcggccgcgg
    10321 cggggcaggg caggacggtg ccgtcgggcg cgacggtgag cgagaccgca ccccagccgc
    10381 ccatgcaggg cttggcgacg ccctcgaagt agtccgggag gacccacacc agctcggtgc
    10441 ggccgccgag cttctcgcgc catcgcgcga cgccctcccg ggcccgggcg agctgctcgc
    10501 gggtgggcag cagggcggcg cggttgcgca gggcccagcc gtagaactgg gtgttggcga
    10561 gttcgacgcg atcggcgccc caggccacgg ccagttcgat cagtgggtcc agcgcgtcga
    10621 ggttgtcgcg gtgcaggacg acgttgacgc ccagcggcag gcccgcctcc cgtaccaggg
    10681 cggcggcccg ctccttggcg gcgaacgagc ggtgtccggc gatccggtcg gaggccccgg
    10741 ggtcggcgtg ctggacggag agctggacgc tgtgcagccc ggccccggtc agcgccgtca
    10801 gccgggcctc gtcaagaccc acgccgctgg tgaccagctg ggtgtagagc ccggcggacg
    10861 cggccgcggc gacgatcacc tccaggtccc ggcgcagcag cggctcaccg ccggacagat
    10921 gggtgtggac gacgcccagc tccgccgcct ggcgcagcac ccgctcccac tcctcgccgg
    10981 tcagctcgcg ggagcggcgc gtcagttgga gcgggttgga gcagtagggg cagtgcagcg
    11041 ggcagccgtg ggtcagctcg gcgagcagcg cccacggacg ggggtgccct tgggggtggg
    11101 cggtcaccgt atccagccct cctcgtgcat ccggtccagg aacgccggga cgtcggtggc
    11161 cacgggggcg ccggggaagc gttcggcgag ttcggccacg atggtgtcga ggtcgcggcc
    11221 gccgtcgcac agccgcagca ccgttccggc ggtgccgcgc aggaccacca cgcgctcggg
    11281 catcaccagc aggtccacct cgcgcacccg gtcgtggcgc aggtgcaccg cgggggccag
    11341 ggccggccgc caggcggccg gggccgtcat atcccctccc ccgccgtgtc cttggtgtcg
    11401 gcgtggtcca cggcgtccag cagggaccac agcacatcgc atttgaaggt cagcgcagcg
    11461 accgcccgtt cctcgtcctc gggggtgcag gcccaggtca ggacgaggtc gagggcttcg
    11521 gcgctgtccc ggctgccctg acccacccgg tcccggaagt agcggagccc ttcgcgctcg
    11581 atccacgggt agtggtgttc gaacgcctcg atgcgggtgc gcatgatgcc gggggcggac
    11641 agttcggtca gcgaggcggc gacggcctcc agcggggtgc ccagacggca gaagttgacg
    11701 taaccgtcga ccgcgagccg tacgccgggc agcacttcgg cgccggtgag cagccgttcc
    11761 cggccgatgc ccgcggcctc gccgagccgc agccaccgct cgatgccgcc ctcgccgtcg
    11821 gcggcgccgt cgtggtcctg gatgcggcgc agccacatcc ggcgcagccg cggggtgtcc
    11881 agcttggcgg tgatgagcgc gtccttgacg gggatgtggc gctggtagtg gaagcggttg
    11941 aggatccagc ggcgcagttc ggcgggggtg agttcgcccg cgtgcatgcg gaggttgaag
    12001 gggtgccggt cgtggtagcg ctcctgggcg actgcgcgca gccgctcttc gaggctccgg
    12061 gtcataactc gatcaccatc ccgtcggcgg ccacctcgat gccccgtccg gcgagcaccg
    12121 cgtgctgggg cgcggccggg tcgttgaggg ggttggtgtt gttgaggtgg gtgtacaggg
    12181 tgcgggcgcc gagtgcggcg agccgccccg ccgttccgcc gggtccgtcg atcggcacat
    12241 ggcccatggc ggtggcggta cgggagccga agccgctgcg caggggctcc tcgtcgtccc
    12301 agaaggtgcc gtcgacgatg acgcagtcgg cctcctcggc ggcccgctgg aaggcgtcgg
    12361 accaggcggc gagggcgggg gcgtagagga gggagcggcc ggtggcgcgg tcccgcaggt
    12421 gcagggcgac gacccagtcg tcctcgtcgg gaccgtccaa ctcggcggca tagcgggggc
    12481 gtttggcgga gacggggacg gcggcgatgg cgaagtcggc atcgcnnnnn nnnnnnnnnn
    12541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12841 nnnnnnnnnn nnnnnnnnnn nnngggtggg cgcgtgcccc cggagcatcc ggggcacgcg
    12901 cagttccact ggggtacgcc gccgcccgcc gcggtgccga gcacacgcac gcgcatggcg
    12961 gctgccgtca gcgggcgttg agcgagtagg cggtgacctc cagcgcggtc tcgacgacca
    13021 cgtagtcggg ggtctgccag gctgtttccg gcgcgggggt ccgggtgtgg tccaccgcct
    13081 cgggagccgt ctgccgcacg gtttcgttca tggcattgac ctgccttccg gtttccgggt
    13141 gtcgggttgg gccagagggt gtctcggcgg gacgtcagcc ggtggtcctg atccgcagcg
    13201 cctcgccgtc ggtggtggtg ctgtgccgga ccacggggcc ggtgacgccg ctgaagccca
    13261 cgtcgtacgg actggcggtg ccgcgcccgg ccgtgacccg gtcgagggtg atgcctaccc
    13321 cgtcgtcggc gatgaacgcg ggccggtcgt cgttggtgtc ggtcgtgacg gcgctgttgg
    13381 tgaaggtgat gcccttggcg tgccggatcc accagccgta ggacgggcgc accccatagg
    13441 tcttggggac gtagtcggtg aggaactcgc cggggaccag ctccgcgtcg gaggcggggt
    13501 ggccgccggg gacggtcagc cgcacccggt cgaaggtgat gtcctccacg tccgcgccgg
    13561 gcgctccggt gatggtgctg gtgtagtcga cgccggtgac cgggtgggtc agcccggtgc
    13621 cggtgacgtt cctgaagcgg atgtcgtgga tccggcccgc gggcggggcg cccgggcagc
    13681 gctttcggtc gccgatcttg atgaagacgg gggtggcgcc cttggtcatg gtgatgtccg
    13741 agtagcggac gtcgctgatg tcggcgccgt ccatggagac gatgccgatg gccgccttgc
    13801 ccccgccgcc gatccggagc cggtcgaagc ggatgtcgcg gaagtcgcca caggtctccg
    13861 agccgaactg gagcgcgttg ttctcggtgg acagcacatc ggagtcatgg acccggacgt
    13921 cctggctggt gtaggtccgg cccagcgcgt agtcgctctt gaggacgacg ccgtcgtccc
    13981 ggccctcgat gcgggactgg ccgatgtcga catggcggct gttgatgagg ttgacggcgt
    14041 cccggtcggt gctggtgagc accttggtgc gggtcatccg tacgccgtcg cagccgttga
    14101 gcagcagcgc gaagtggccg ccccgggtga aggtgacgtc ctggatgtcc aggtcggcgc
    14161 agcgcttgag ggagaggatc ttgtcgccga cgcccggttc cagggtgttg ctggtgccca
    14221 gcccctcccc gtcgagggtg ccggacccgg tgatggcgag gtggtggatg ttctcgcccg
    14281 tcagcagcgc gttgcggaag tggctgtggc cgaagtcctg gtaggcgtcc caggggttgg
    14341 gctcggcctc gtccatgcct ccggcggcgg cgagcagcgt cgcgcccttg gcgaggtgca
    14401 gggtgatgtc gctcttgagg tggagggtgc gggacttgta ggtgccgggc gggaacagca
    14461 cggtgccgcg gccgggagcg gcggctgccg cgtcgatcgc ccggtcgatg gcgtcgtcgt
    14521 ccagcgtcgt gccgtcgccc gtggccccgt agtcgcgtac gtcgtacgta cggtcggcgg
    14581 cgccgggctg tgcggtggcg gtctggggag ccacggcgag caggcaggct gcggccgccg
    14641 tgatgacggc ggtccgtaag cgcgtcgagc gcgtcatgaa tcgcccttcg ggtagccgga
    14701 tccgatgcgc acctcgtcga tcagcagctt ctgatagcgc ttggtgtcgg tggccgcggc
    14761 ccaggtgctg ttgacggtga gccggacaaa gcgcttggtg gtcgcgggga ggtcgatgaa
    14821 ctgcaccccg cgggcgctgg gcagggttcc ggccttgacc gggctgcccc aggtgctgcc
    14881 gtcgccggag acctgcacct ggtagtcacg gatccgggcg gactgttcgg tgtcggaccg
    14941 ggcgtaggag accgaccact cccgctggtt gacggccaga taccggacgc ttctggccga
    15001 gcgcagatcg aaggtgaccg tggcgggcag cttggtgttg ttgtcccagt aggtctgcgg
    15061 atcgccgtcg aggacggcgg aggccgggtg gccgctcgcc gaggcactgg cgctcgcggt
    15121 catggagtcg gccggaatca gcccctgcct gccgtcggtc cggacgctca ggacggtgtc
    15181 gtacggatcc cagccgctga tgccggagac ggtgagcttt ccctcgccct ggctgaaggc
    15241 cagtttcctt ccggtacgga agtcggtgac gcccgatacc cggtagccgt tgtcccgtac
    15301 ggtcagtgtg gagccggacg gcttggtcag gacgtggagg tagtgctggt cggggtcggt
    15361 cctgctgacc gtggtcaccc cgcgggcgcc gtcgttccag gagccgggct ggagcccgcc
    15421 gtacgcatag ccaccgccct cggtgccgtc cagcgagccc cagatcttgt cgagataggt
    15481 cttcgcggcg ttgttgaagg cttcctgttt gctggggaac ttcccgttca cctgggctgt
    15541 ttcggccatg agcgacttca cggaggatcc ggagttgctg atcagccggc ccagggtgag
    15601 tccgtggtcc accgccgagt cggtgccgct gtaccaccag gcgccgctgc tcgggagctt
    15661 gaagcaggcc tcggtgagcc gcggctgagg ggtccagatg gcctgcggat agtcgtacgc
    15721 cggggtcatg ccggtcttct gctcattgct gaccgtgtcc atgatcggcg tgtcttcgtt
    15781 gttgttgctc agcagccagg acgggcggtc ggcgcggatc ttctcgtaga ggccgtggtc
    15841 gagccagtag tcgttgtcgt tgtcgatcca gaaacccgaa agcttcgggt acttcttcat
    15901 cacttcgacg aagttgtcgt acgagtactc accgaatccg tcgcgcgtgg tcaggtcgac
    15961 gtcacggccc ttggaggcgg agtacgccgc cgagtcgagc cattcatggc cgccctcgtc
    16021 gtgccactgc ggatcgtcgg tcatgtagag catgaccttc agcccctgct tgcccgccgc
    16081 gtcgaccagc tcgcccagga agtcccgctt ggtggagcaa ctgcccggga tggcggaggg
    16141 ccaggcgcgc gcgtatccca gccggctgtg gaaggaggcg aggacgaggt acttggcgtg
    16201 cagcttcttg gcctcgtcca cccagtagcc ggcactccag ccgccgtcgg tcaccgcctt
    16261 ctcccaggcg gcgcagctgg tgtagccggg cgaggtgcgc atgccccagt gcaggaagag
    16321 gcccgcctgg gagtcccgga gccactgttg ccgggggttg accacctcgg cccgggcggg
    16381 gaccggaccg gccagggcga gcgtgccgat ggccagcagg acggcggcca gccaggcgcc
    16441 taggcggcgc gaactgcggc ccatgggcgg ctccttctcg ggggcgcggt ggggtgcgac
    16501 gggatggcgt tcctgatgca gcgtcacggc ctggcggtgt ccggtcaata agcgtgcagt
    16561 caaaatcctc cgatctcttg tgcgggacat acggtgcacg attcagcgaa acaagcggaa
    16621 tccgcaggta gttgaggggt tcaggccccg agaacctgcg gcgaccgccc tcttggtccg
    16681 caccattcct tgactcatga gggcacacct cctaccttca cagtccccca atgtgaacaa
    16741 ggatcagaca ggagaatcct tgatggagcg cccaccgctc ttaccgcgca ccgccctcac
    16801 cctcgcggcc accgccgcgc tgatcgctcc ggccgcggtc gcctacggca cggagcgctc
    16861 cccgcaggcg ccggccgcgt cctggagcct caagtggaac cccgcgtcgg gcgcgagtgt
    16921 cgccagcgcc ttcgagggcg ccgaggacga ccgcgccgac tcccaccccg gaaccaccca
    16981 catctacccc tcccagggcg gtttccggac cgatatgcac taccccaggg acgtggacac
    17041 cagcaccgac cgccagcgca acgaggtccg gggcatgaag caggacggct ccgccgtcaa
    17101 gatcctgaag aacgagacct ggcgcatcca gtaccagatg tacgtgccgg acacgctgga
    17161 cgcgacgacg agcttcaccc acatcatgca gatcaaggtg ggggacgtgg ccgccccgct
    17221 gttcaccatg tcgctgcacc agcacgacaa cggcccgaag gtcgaaatcc ggacctcgga
    17281 cgacgacgac aacctgaccg aggccggggc cgcgaacatg gcgccgctcc agggcgcctg
    17341 gagcgatgtg tcggtcgagg tcaaggcggc cgactcgggc gcgtacgccg actggtcggt
    17401 gaccaccggc ggcaaggaag tcgcctcgta caagcgcacc ggcctggacc tgtggcgcgg
    17461 caagaactac ctgcggccca agtggggcat ctaccggagc ctgaacagca gcggcctcca
    17521 gaccacgtat ctgctcaccc ggaacttcaa ggcgtacaag ctccaatagg aggacacgcg
    17581 atgaagagct gtcggaacac cctggtggcc gcggccgcca ccacagcgct caccgccggg
    17641 ctgctgctca cccaggcggg caccggcaac gccgcaccgg ccgcggccga ttccgtcccc
    17701 tcagccatct cgacggtctc gtccggctgg tcgatcccct gggggctgag ctggctgccg
    17761 gacggctcgg cgctgatcag cgagcgggac tcgttcaaac tcttcaagct cacccagtcg
    17821 ggcgccaaga cccaggtggg cacggtgccc aatgtggtga ccaccagcgg cgagggcggg
    17881 ctgatgggcc tcgcggtgtc cccgaactgg aacaccgatc actacgtcta catcatgcac
    17941 acggcgtccg acggcaaccg gatcgcccgc atgacctacg acggttcctc actgagcggc
    18001 tacaaggcga tcgtcaccgg catcaagaag aacaagtacc acaacggcgg gcgcctcaag
    18061 ttcggcccgg acggctatct gtacgccacc accggggacg cgcagacatc cagcaacgcg
    18121 caggacaaga actcgctcaa cggcaagatc ctgcggatga ccaccgacgg caaggccgcc
    18181 cccggcaacc cgttcggcac cctcgtctac tccctgggcc accgcaaccc gcagggcctc
    18241 acctgggacg cgcagggcag gctgtgggag gcggagctgg gcaacagcac gtacgacgaa
    18301 ctcaacctca tcgaggcggg caagaactac ggctggccca cctgcgaggg cagctgctcc
    18361 acctccggga tgaccaaccc caagcgccag tggaccgtcg gcgaggcatc gcccagcggg
    18421 gtcacctatg ccgacggcgc cctctacatg gcggcgctcc ggggcgagcg gctgtggcgg
    18481 atcccggtcg acgggacgag cgcgggcacc ccgaaggcgt actacaccag ctcgtacggg
    18541 cggctgcgca ccgtcgagac ggtgcccggc aagaacacgc tgtggctgtc cacgacgaac
    18601 gccgacaaca acggcgggga ggcggacggc gcggacaagg tgttccaggt cgagctgaag
    18661 tagcacgcgc cggcatgcgt acggtcgcgc tccccgggga gcgcgaccgt acgcccgtgt
    18721 cagtacgcca gccgctcgtt catcagcagg aaggcgccca gcccgtgcag gtcgttcgtg
    18781 ttgcgcttgc ggccgaggta gtacgccaga tcaccgacgt tggtgccctc gctgatgtcg
    18841 gcgatgctgg tcagcccgtc cgcgtcgacc gtcaccttgt ccaggacgcc ccggtagccg
    18901 cggcgcgccg ccgccgcgta gtcgccgccg cggatccatc cgtggtccag ggcggcgtgg
    18961 agcatcaggg tgtacatgct ggaggccgag gtctcggtcc agttgcccgg ctcgccgggc
    19021 ttgtcgacga cctggaacca gcggccggtc gcccggtcct ggtagcgcag gaaccccttg
    19081 gccaagtgcc gtacgttggc gatgagttcg gcgcggcgcg gatggcgggc gggcagcatc
    19141 tccagcacct cgatgtgcgt catcgcggtc cagccgatgg cgcgggccca gaagtgggcg
    19201 gaggtgccgg tggcgtcatc cgggttccag ggggcgtcgc cgtccgcgtc gtaggcgtgg
    19261 tagatcagcc cgttcgacgc cttgaggtgg cggaagtaca ccgcgaggtt ccgggtgacc
    19321 tcgtcgtacg cgtagctctt gtccccgtac gcgatgccgt accgcagcag gaacggctgg
    19381 gccatgaaga cgccgtcgcc ccacagttcg ttggtcttgc cggtggcgtg ccacatgccg
    19441 ccgtccgcgg tgcggggata gtcggcgaag cgggcgcgga tctggtcggc ggccgtccgg
    19501 tagcgtgcgt cgccggtctc ccggtggagc atcagcagca gattgccgga ctgcatggcg
    19561 tcgaggttgt cgaaggtgcg gctcatatgg ccgtcggcgt ccacgaagtt gtccacccag
    19621 cgcttgatgt acgccaggta cgagggctcg cccacccgct ggtagacgcg gtacgccccc
    19681 agcaggaaca gcccccgggt gtagccccag ccgccgagcg aggccgggtc cgggtagcgg
    19741 gcgacggtgg agtccaccac cgcccgcgac cagtcggtcc gggctgccgc gtgggccacc
    19801 ccggtccccg gcagcagaag gccgccgccg atgccgagcg cgctcgcgag tacggtcctg
    19861 cgtctgatca tggggagttc cctcttttca gttcaggatg ccatgtacac gccaaggata
    19921 gcgtcgagcg caccgtaccg ggtcaaacct ggaggaaagg gccggatccg catcccccgt
    19981 cagcagcccg gccaccagcc ggccggtggc gggggcgagc atcagcccga gcatgttgtg
    20041 accggtcgcc agcagcaccc gggagtggcc gggcacccgg ccgatcagcg gcagcccgtc
    20101 gggggtcatg ggccgcgggc ccacccactc ctcctggagg tcgtcccagt cggcatggcg
    20161 cagatacggg cgcgcggccg cgacgatggc ctcgacgcgc cgccgccgga accggtcggg
    20221 gtcgcgctcg aactccatcg tcccggcgac ccggacccgc ttgcccatgg gcgtgagcac
    20281 caccttggcc gcgccgaggt ggaccagccg ggagggcggg ggctcggccg ccaccgagaa
    20341 gctgtagccc ttgcccgcca ccagatcgag gtccacgccg agcccgcgga ccagttcgcg
    20401 ggaccagatg cccgcggcga cgaccaccgc gtcgctccgg tacgtccccg ccgaggtccg
    20461 cacctcggcg cgcccggccc gctcactgac ggccgacacc cgggcgccct cgaccagttc
    20521 gacgccctga cggcgcagcc gctcggcgag ccggtccacg aagagcccgg ggtccagcga
    20581 ccactggtcg tccaccacga accccgcccg ggccccctcg gtgagcgcgg gctcggtgtc
    20641 cgcgagggcg tcccccgtga gcacaccacc ggcggcgatc ggcgcgccca gccggcggaa
    20701 ggcggtgagc gccttggcgg cgtacgcgcg ggacggaaag gcgaacagga acccgtcctt
    20761 gtgcgcctgg ccgtccacgc cgagcgcctc cagctcctcg aagagttcga aggtgccctt
    20821 cgaagagcgc gccgagcgcg ctcgcgccgc ggtcgtggtg gcgtgcggtg gcgcgcagcc
    20881 cgaagcggac gaggaagcgc accagttcgg cgctggtcga cggatggacg gccagggcgc
    20941 tgtccgggcg gtgcagcccg cgcagcgcgg tgccgatgac gccgggggcg gcgagcggtt
    21001 ccaccaggtc ggggcagacc tccccggcgt tgccgcggga ggcgccgctg cccagccggt
    21061 cgcgttccag gacggtgacc cgcagcccgg cggcggcgag ggagtgggcg cacatcaggc
    21121 cgacgactcc gccgccgacg atcgtgaccg aggagggcgt ggcaccggag agggtcatga
    21181 cgtctccttc accgtgggcc gcggtgtggt cgggtcggcg gcggtgccgc ggcggaggcg
    21241 ggagcggccg cgcggatcgc cgtcgcggtc gaccgcgctc gcgtcggcga gggtcagccc
    21301 gctggtctcc ggcgcgagga cgtatgacgc ggcccagccg atgacgcaga tgaccgcgcc
    21361 gaggagcatc gccagccggg tgctgtgggc gaggacgacg ggcgctcccc aggtgccgag
    21421 tgcggcgccg atccggctga tgccggtggc gaagccgttg gcggtggcgc gcaccccggt
    21481 cgggaagagc tcggagggat agatggcctg gaggcactgg ctggagaagc acgccacgcc
    21541 gaaggccgcg aagagcacga ccacgacggc cggtgcggga tgggcgaagg cggcgagggc
    21601 gagcaggggg atggcggaga ggccgaagct ccacagcagc agggtgcgcc gccccttgtt
    21661 gacgaccagg atcccggaga gcgagccgag cacgaagaag atctgcacca cgaccgagcc
    21721 gaggtacgag tcgttgccgt cggccagtcc gaaggaggcc aggatggtgg gttcgtacgt
    21781 ggtgatggcg tagatgggca gcagctggca cgcccagaag acgctgatga agacggtcct
    21841 gcgcagatag gcgccgcgga agatgtcgcc gtagcgggtg cgcgaggcgg tgtccgcctc
    21901 cagctcggcc agggtcgcgt ccgggccgag catctgcttc agcacggcct cggcctcgtc
    21961 ggtacgcccc ttgctgagca gccagcgcgg ggactcgggg gtgccgaagc gcagcagcag
    22021 gatgaggacg gcggggatcg cgctgctcgc gagcatccag cgcca
//
