LOCUS       NZ_GG770539            21047 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. SPB074 supercont3.1, whole genome shotgun sequence.
ACCESSION   NZ_GG770539
VERSION     NZ_GG770539.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SPB074
  ORGANISM  Streptomyces sp. SPB074
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6808467)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     The genome sequence of Streptomyces sp. strain SPB74
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6808467)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
REFERENCE   3  (bases 1 to 6808467)
  AUTHORS   Fischbach,M., Godfrey,P., Ward,D., Young,S., Zeng,Q., Koehrsen,M.,
            Alvarado,L., Berlin,A.M., Bochicchio,J., Borenstein,D.,
            Chapman,S.B., Chen,Z., Engels,R., Freedman,E., Gellesch,M.,
            Goldberg,J., Griggs,A., Gujja,S., Heilman,E.R., Heiman,D.I.,
            Hepburn,T.A., Howarth,C., Jen,D., Larson,L., Lewis,B., Mehta,T.,
            Park,D., Pearson,M., Richards,J., Roberts,A., Saif,S., Shea,T.D.,
            Shenoy,N., Sisk,P., Stolte,C., Sykes,S.N., Thomson,T., Walk,T.,
            White,J., Yandava,C., Straight,P., Clardy,J., Hung,D., Kolter,R.,
            Mekalanos,J., Walker,S., Walsh,C.T., Wieland-Brown,L.C., Haas,B.,
            Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, Broad Institute
            Microbial Sequencing Center
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2009) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
REFERENCE   4  (bases 1 to 6808467)
  AUTHORS   Fischbach,M., Ward,D., Young,S., Jaffe,D., Gnerre,S., Berlin,A.,
            Heiman,D., Hepburn,T., Sykes,S., Alvarado,L., Kodira,C.D.,
            Straight,P., Clardy,J., Hung,D., Kolter,R., Mekalanos,J., Walker,S.,
            Walsh,C.T., Lander,E., Galagan,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform
  TITLE     Direct Submission
  JOURNAL   Submitted (25-FEB-2008) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Arachne v. April 2007
            Genome Coverage                   :: 12x
            Sequencing Technology             :: ABI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 01:42:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,117
            CDSs (total)                      :: 6,045
            Genes (coding)                    :: 5,425
            CDSs (with protein)               :: 5,425
            Genes (RNA)                       :: 72
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 261 of 620
            Pseudo Genes (incomplete)         :: 378 of 620
            Pseudo Genes (internal stop)      :: 38 of 620
            Pseudo Genes (multiple problems)  :: 54 of 620
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 729575
            Orig. end                         :: 750622
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            GG770539.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated scaffolds were added in May 2010.
FEATURES             Location/Qualifiers
     region          1..21047
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="4"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21047
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21047
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11047](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11047)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     gene            complement(408..1355)
                     /locus_tag="SSBG_RS02950"
                     /old_locus_tag="SSBG_04211"
     CDS             complement(408..1355)
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065010.1"
                     /locus_tag="SSBG_RS02950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04211"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_008744748.1"
                     /sec_met_domain="fabH (E-value: 3.5e-87, bitscore: 290.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSRIVALGHYQPGRVLTNEDLAALVDTNDAWITSRVGIRTRHI
                     ASDDEPVDELAAYAGAKALATAGLTPGSVDMVIVATSTAVDRSPNTAARVAARLGMPSP
                     AVLDVNVVCAGFTHALALADATVRAGSARQALVIGADKMSAVTDWTDRTSCVLVGDGAG
                     AAVVEAVAPGEEPGIGPVLWGSNPAMGSAVRIEGTPARFAQEGQTVYRWATTQLPAIAR
                     QVCERAGLTPEDLAGVVLHQANLRIVEPVVRRLGAVNAVIAKDVVDSGNTSAASIPLAF
                     SKLVERGELSSGDPVLLFGFGGNLSYGGQVVRCP"
     misc_feature    complement(1738..1751)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.73"
                     /tool="antismash"
     gene            1764..2381
                     /locus_tag="SSBG_RS02955"
                     /old_locus_tag="SSBG_04210"
     CDS             1764..2381
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007820061.1"
                     /locus_tag="SSBG_RS02955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04210"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_008744749.1"
                     /transl_table=11
                     /translation="MSEESGEGARPAGARPAVRRPRLTPAREDEFLDAALAVVRETGYE
                     ALTMEGVAARAQCGKATLYRLYGSKQRLVAAAVSRTRPAHRVPLDTGSLRGDLLAAARR
                     AAAEFEDSTTLVWAVAHASIEDRALHDALRLAFIDPEAADLDATVDRALARGELSHRPA
                     AARHLDGLLFGAALVRSLDGETAPSGLEALVDDVILPALLHS"
     misc_feature    complement(2402..2416)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
     misc_feature    2403..2417
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.6"
                     /tool="antismash"
     gene            2472..>3988
                     /locus_tag="SSBG_RS02960"
                     /old_locus_tag="SSBG_04209"
     CDS             2472..>3988
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010277287.1"
                     /locus_tag="SSBG_RS02960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04209"
                     /product="MFS transporter"
                     /protein_id="WP_008744750.1"
                     /transl_table=11
                     /translation="MSSPATGAPARPGAAGTAGSAPGPVPHRWLIMVFISAAQLMVVLD
                     ATIVNIALPTAQLDLGFSDADRQWVVTAYSLAFGSLLLLGGRVADLFGRKNAFLIGLLG
                     FALASALGGAASSFEVLIVARAVQGLFGALLAPAALSLLTTTFTDPAERGRAFGIFGAV
                     AGSGAALGLLLGGLLTEHLNWRWTLYVNIVFAAVAFTGGLLLLRRTARDRTKKLDVPGT
                     LLASAGLFCLVYGFAHAETHAWSSPGTWGLLLASVLLLAAFCFWQTRTPHPLLPPRILL
                     HRDRGAAYVAMLVAGAAIFGISLFLTYYLQQVLELSPVRTGLAFLPMSFAIMVTATTGA
                     SVLLPRFGPKLVVSAGMLLGGAGALWLSRLDVDSSYAGHVLPPLIIAGLGMGAVMATAM
                     SQATAGVAHSDAGAAGALVNTMQQVGGSLGTALLNTVVASGAADYLAAHDAREPGARLA
                     AGVHGYSDAYVWTAVFFAAGLVAAGLLFRRRRTHRAGERPAPGRPRV"
     gap             3989..4088
                     /estimated_length=unknown
     gene            4210..4875
                     /gene="fdhD"
                     /locus_tag="SSBG_RS02965"
                     /old_locus_tag="SSBG_04208"
     CDS             4210..4875
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fdhD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552586.1"
                     /locus_tag="SSBG_RS02965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04208"
                     /product="formate dehydrogenase accessory sulfurtransferase
                     FdhD"
                     /protein_id="WP_267880253.1"
                     /transl_table=11
                     /translation="MGRVTERRRVTRVRAGVVSARPDTLVAEEPLEIRLAGKPLAITMR
                     TPGDDFALAAGFLVSEGVLASAEDVRSIVYCAGATDDGSNTYNVVDVQLAEGVPLPDFT
                     LERNVYTSSSCGLCGKASLDAVRTTTRFPLADTPPPRLAPALLSALPDRLRAAQRVFDR
                     TGGLHAAALFSETGELPDIREDVGRHNAVDKLVGRALTDARLPLSRAVLLVLEAISFG"
     misc_feature    4852..4854
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4894..5702
                     /locus_tag="SSBG_RS32035"
                     /old_locus_tag="SSBG_05112"
     CDS             join(4894..5238,5241..5702)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="SSBG_RS32035"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SSBG_05112"
                     /product="IS5 family transposase"
                     /protein_id="WP_234010287.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MVGLVERLVPDELWQLFQRVVPEAPSRPQGGGRRRHGDREVLAAI
                     VFVATSGCTWQQLPSASFGPSGATAHRRFSEWSKARVWAKLHRLVLDELGTRGELDWSR
                     CAIDSVNMRALKGDLTGPNPVDRGKYGSKIHLITERTGLPISVAISGANVHDSQALIPL
                     VKGIPPISSRRGPRRRRPGKLHADKGYDYRHLRQWLSGRGIRHRIARKGVETSQRLGRH
                     RWTIERTMSWLAGCRRLHRRYERKADHFLAFTSIACTLICYRRLTK"
     gene            <5715..5912
                     /locus_tag="SSBG_RS30585"
                     /old_locus_tag="SSBG_04206"
                     /pseudo=""
     CDS             <5715..5912
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009069831.1"
                     /locus_tag="SSBG_RS30585"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04206"
                     /product="formate dehydrogenase accessory sulfurtransferase
                     FdhD"
                     /pseudo=""
                     /transl_table=11
                     /translation="GRASFELAQKAAMAGIPVLAAVSAPSSLAVDLAAETGMTLVGFLR
                     GESMNVYAGQERLVLEGAEV"
     gene            complement(6129..6893)
                     /locus_tag="SSBG_RS02980"
                     /old_locus_tag="SSBG_04204"
     CDS             complement(6129..6893)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="SSBG_RS02980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04204"
                     /product="MFS transporter"
                     /protein_id="WP_234010324.1"
                     /transl_table=11
                     /translation="MASNVAGVHVERQLRRPVLPAMHGCYSLGTVVGAGLGVAGAAVGF
                     PVPWHLALVLLLVLALFAYAIPGLRPGIGASRADDAGAARERRLYLDPRLLLIGGVVFG
                     MTLAEGAATDWLPLLMVDGHDMPAGLGSLVYTGFAATMAAGRFAGGPVVTRFGRAKVLG
                     AGALLTAVGIALVSFVDNPATAGCAVLLWGLGTSLGFPLALSAAGASGPDTAARVALTS
                     RIGYVALLAGPRASASSATTRACERRCSRSWP"
     gap             7041..7417
                     /estimated_length=377
     gene            complement(<7418..8413)
                     /locus_tag="SSBG_RS02985"
                     /old_locus_tag="SSBG_04202"
     CDS             complement(<7418..8413)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010275319.1"
                     /locus_tag="SSBG_RS02985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04202"
                     /product="bile acid:sodium symporter family protein"
                     /protein_id="WP_037871007.1"
                     /transl_table=11
                     /translation="MKRPRLPLDPYILSLLGTVLLAALLPARGGVASGVSGASTAAVAL
                     LFFLYGARLSTAEALDGLRHWRLHVTVLAATFLVFPLLGLAAYTLRPWLLSPDLFTGFL
                     FLTLVPSTIQSSIAFTSLARGNVPAAICAGSFSSLFGIVLTPLLAAVLLGDSGGGFSAA
                     SLGRIVVQLLLPFLAGQFLRRWVGGFLTRHKKVLGYVDRGSILLVVYTAFSEGMVRGIW
                     HQVTVPRLLALLLAEAVLLAAMLGLTWWGAGRLGFPRADRVAIQFAGSKKSLASGLPMA
                     SVLFGAHTSLAVLPLMVFHQMQLMVCAVIARRRAAQAAPEAAGAGEPAAVP"
     gene            8550..9413
                     /locus_tag="SSBG_RS02990"
                     /old_locus_tag="SSBG_04201"
     CDS             8550..9413
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009069825.1"
                     /locus_tag="SSBG_RS02990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04201"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_008744755.1"
                     /transl_table=11
                     /translation="MYEPSHLRTFLTVAQTLSFTRAAQRLGVRQSTVSQHVRRLEEQTG
                     RPLFVRDTHSVALTEDGEAMLGFARRLLAVQEQAVAHFAGTRLRGRLRFGASEDFVLTR
                     LPEILESFRRAHPEVDLELTVELSGTLHERLAEGRLDLVLAKRRAEETHGVLVWRDTLV
                     WVAGERLRLDAERPLPLIVYPPPGITRDRALRVLEREGRAYRVACTSGSLNGLVAAARA
                     GLGVMPHARGLIPPGLVRVPERAGLPALGDVDFVLVHDDRRAEAREPGRALAEAILASG
                     DRLHGA"
     gene            9463..10047
                     /locus_tag="SSBG_RS02995"
                     /old_locus_tag="SSBG_04200"
     CDS             9463..10047
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010275337.1"
                     /locus_tag="SSBG_RS02995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04200"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_199781330.1"
                     /transl_table=11
                     /translation="MRTEVAEDGTGTGGGPGLAEWALRAVGAADLDALVEIRAEVMRAD
                     LERLGRYDERRVRRRMRDSFSPAHTSVILSGGALAGCVTLRPAEDGGHWLEHFYLAPRH
                     QGRGLGGAVLRSLLERANGRPVRLHVLRGSAAQRLYARHGFAVEDEGPVDVLMVRPPGV
                     AGPGAAPATPGTAPRRLRAERGGPGRPPSGR"
     gene            complement(10001..11047)
                     /locus_tag="SSBG_RS03000"
                     /old_locus_tag="SSBG_04199"
     CDS             complement(10001..11047)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000172: Biaryl bond formation (66% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007820080.1"
                     /locus_tag="SSBG_RS03000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04199"
                     /product="cytochrome P450"
                     /protein_id="WP_008744757.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 2.8e-178,
                     bitscore: 590.7, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 4.4e-16, bitscore: 57.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHTPTRAPERKILFAPPLDNLLREHLGADLFRPEPDTVGIAGP
                     ALVDRVLAARPAGKTERPTFKPLLGRAIPHQRAATQMQAVGHDVRAALKREAPRDPDLS
                     GLWPHVGHVYLRDLILGGDPRRLRVLMNRAMELTPKLTWTVIAAGAALPAPRRRTGTTR
                     LAALGLEAGTYQERRYAMGLYRRTAAPVCFTISTLVANALWLGAPFDPDIPSRHLVHES
                     LRLLPPSWNILRNSSPEYPAIDARITPADDVLVLPFLSHRDPALWENPEEFRPERWEEK
                     DPERTPGYLPFGHSSERCWGRHMVMPLAEMLLDMIRSSGLVVDPRQRVARVPLTGLMGV
                     DRVRLVQP"
     gene            complement(11158..11577)
                     /locus_tag="SSBG_RS33035"
     CDS             complement(11158..11577)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038372.1"
                     /locus_tag="SSBG_RS33035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptorubin family RiPP precursor"
                     /protein_id="WP_158677734.1"
                     /transl_table=11
                     /translation="MASKRRAVLLHGICTEAARVSAGERASDGLLAASGAATSPRRARW
                     INPGALFRTGGPAKRPGEAPCVTFFPGALTGHQSLVFTDHRRAEGESDRSTGKRAVFLH
                     RPTRKEGKKMRLLFSLKNKLSQQKSLKAHAWYIWY"
     gene            11609..12417
                     /locus_tag="SSBG_RS32040"
                     /old_locus_tag="SSBG_05114"
     CDS             join(11609..11953,11956..12417)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="SSBG_RS32040"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SSBG_05114"
                     /product="IS5 family transposase"
                     /protein_id="WP_234010287.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MVGLVERLVPDELWQLFQRVVPEAPSRPQGGGRRRHGDREVLAAI
                     VFVATSGCTWQQLPSASFGPSGATAHRRFSEWSKARVWAKLHRLVLDELGTRGELDWSR
                     CAIDSVNMRALKGDLTGPNPVDRGKYGSKIHLITERTGLPISVAISGANVHDSQALIPL
                     VKGIPPISSRRGPRRRRPGKLHADKGYDYRHLRQWLSGRGIRHRIARKGVETSQRLGRH
                     RWTIERTMSWLAGCRRLHRRYERKADHFLAFTSIACTLICYRRLTK"
     gene            12640..14462
                     /locus_tag="SSBG_RS35340"
                     /old_locus_tag="SSBG_05115"
                     /pseudo=""
     CDS             12640..14462
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951950.1"
                     /locus_tag="SSBG_RS35340"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SSBG_05115"
                     /product="AMP-dependent synthetase/ligase"
                     /pseudo=""
                     /sec_met_domain="AMP-binding (E-value: 2.3e-18, bitscore:
                     64.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREFSQPPLTRARPVGGLADCVFDHAIEDPERVVLARKSGGRWED
                     VTAAGFRDQVLAVAKGLLAEGIRFGDRAALMAPTRYEWTLLDFALWTVGAQVVPVYPTS
                     SAEQVFWMLHDAQAAAAFVEHEDHAMTVGSVIDRLPHLRRLWQFDAGAEQELMAAGAGL
                     ADEVVHRHRRRSRRTRSPRSSTPRARRAAPRAAS"
     gene            14669..15454
                     /locus_tag="SSBG_RS03020"
                     /old_locus_tag="SSBG_04195"
     CDS             14669..15454
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031003.1"
                     /locus_tag="SSBG_RS03020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04195"
                     /product="aldo/keto reductase"
                     /protein_id="WP_050776854.1"
                     /transl_table=11
                     /translation="MPQLGFGVWQVPDEEATTAVGLALDAGYRSIDTAAVYGNERGTGK
                     AIAASGLAREELFVTTKLWNGAQGYDPALRAFDASLDKLGLDYVDLYLIHWPCPAKDRY
                     VDTWRAFEKLLADGRVRAIGVSNFTPAHLERLLGETSVIPAVNQIELHPHLQQGEARAF
                     HGEQGIATEAWSPLGQGKGLLEVPALVAIGQKHGRTPAQVVLRWHVQLGNVVIPKSVTP
                     SRIKENIDVFSFELDEEDMAAIRALNEEHRLGGHPDEVN"
     gene            complement(15592..16309)
                     /locus_tag="SSBG_RS03025"
                     /old_locus_tag="SSBG_04194"
                     /pseudo=""
     CDS             complement(15592..16309)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007820090.1"
                     /locus_tag="SSBG_RS03025"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04194"
                     /product="class I SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLDYDEEAARYDESRGGLPRARAAAEALAGLLPRRTRTVVDLACG
                     TGIVGGCLREAGFTVRGVDLSAGMLQKAAGRLDGVVRADARALPFASGSADAITAVWLL
                     NLVEDAAPFVAEAARVLRPGGLFVTTVDKSAAHAAGEDTDALLAPYRPVELPDGAGRVT
                     ALAAAHDLRPHGSARFTGHGQGTQPARDRRARARRRSVRAGRRGTDPPPRSAAPSRHAA
                     PRPGLHAARAAQAQPGL"
     gene            complement(16312..16623)
                     /locus_tag="SSBG_RS03030"
                     /old_locus_tag="SSBG_04193"
     CDS             complement(16312..16623)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009069810.1"
                     /locus_tag="SSBG_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04193"
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_008744760.1"
                     /transl_table=11
                     /translation="MPAARPLPAAEIGTALATLPGWSAEDDRLTRFYRLPGHLAAAALV
                     LHIASVQEEMDHHADLTLGYNTVEVATHTHSAGGRITALDVTLARRVEELSAAHGARG"
     misc_feature    complement(16781..16796)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.87"
                     /tool="antismash"
     gene            16861..18081
                     /locus_tag="SSBG_RS03035"
                     /old_locus_tag="SSBG_04192"
     CDS             16861..18081
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007820095.1"
                     /locus_tag="SSBG_RS03035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_04192"
                     /product="chitinase"
                     /protein_id="WP_008744761.1"
                     /transl_table=11
                     /translation="MRRLRAVLCGAAASALAAAGLTALLPASASGAESATLDKRWYAAA
                     PYLMPLDNDPPSATAIMDASGLKAFQLAFILAPNGGGCSPTWDGTAPVSSDTAVGSVIS
                     AIRAKGGDVSVSIGGYGGTKLGQSCTDAASTAAAYQQVITKYQLKAIDFDLEEPEYENT
                     AAIAREIGAAKILQKNNPGLYVSVTTAGTADGTGWFGKQMLNEAKAQGFTPDNFSIMPF
                     DGGFNGAASQTAALTAFNGVLRSTFGWSEATAYAHEGFSGMNGRSDTGEYFGQADFQTV
                     LDYTTTHGMARFTFWSLNRDRQCSPADNGGRTSGTCSSVPQSAWDFAKFSVKFAGATPP
                     ANPPTDPPTDPGTGQCAAGAWSAGAVYVKGDKVTQDGHTWEAKWWTTNEKPGTTGEWGA
                     WQDDGPC"
     gene            complement(18158..18658)
                     /locus_tag="SSBG_RS03040"
                     /old_locus_tag="SSBG_05116"
     CDS             complement(18158..18658)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007820097.1"
                     /locus_tag="SSBG_RS03040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSBG_05116"
                     /product="DUF4396 domain-containing protein"
                     /protein_id="WP_037868809.1"
                     /transl_table=11
                     /translation="MDHAHHGDRPAPHGGPAGWSGTPWSMAARATLHCLTGCAIGEILG
                     MVIGTAAGLHNGATVALSIVLAFVFGYALTARGVLRAGLGPRAAFKVALAADTVSIAVM
                     ELIDNTAMVAVPGAMDAGLADLLFWLSLAGSLALAFLVTTPVNRWMIGRGKGHAVVHAH
                     HGH"
     misc_feature    complement(18712..18728)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 25.73"
                     /tool="antismash"
     misc_feature    complement(18713..18728)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 29.15"
                     /tool="antismash"
     gap             18878..19004
                     /estimated_length=127
     misc_feature    complement(20025..20038)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(20290..20308)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.09"
                     /tool="antismash"
     misc_feature    complement(20477..20495)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
ORIGIN
        1 tccaggagcc ggtccacctc gacggccagc ttggaccgcg agagatcgac ctggtcaccg
       61 agttgcgcac gggagttggg gcctccgtcg cgcagcagtc gcagcagccg ggcctggtgc
      121 gtgttggcgg gtcgcgctgt catgcgtctc acgcgcccct ccccgcctca ccggctgtcc
      181 gattccctcg ccgccgcccg ccgccgcggc ccgcttgcgg cgggtcgcgg cgttctcgcg
      241 ctcacgggcg ttcgcgcttt cgacgtggaa cgtagcagtg gggtacggga aggggaagga
      301 cttgcgcggg aattggcccc tactttctcc cggctcagga caaaggagcg gcggaggcgg
      361 ttcattgagc gcgcgggcgg ggtgatatgc cccgccgggt ggggatttca ggggcagcgg
      421 acgacctggc ccccgtacga gaggtttccg ccgaagccga agaggaggac gggatcgccg
      481 ctgctcagct cgccgcgctc gacgagcttg gagaaggcga gcgggatgct cgccgccgag
      541 gtgttgccgg agtccacgac gtccttggcg atcacggcgt tgacggcgcc gaggcggcgc
      601 acgaccggtt ccacgatgcg caggttggcc tggtggagca cgacgcccgc gaggtcctcg
      661 ggggtgagcc cggcgcgctc gcacacctgc cgggcgatgg cggggagctg ggtggtggcc
      721 cagcggtaga cggtctggcc ctcctgcgcg aagcgcgcgg gggtgccctc gatgcgtacc
      781 gcgctgccca tcgccgggtt ggagccccac agcacgggcc cgatgcccgg ctcctcgccc
      841 ggcgccacgg cctcgaccac ggcggccccg gccccgtccc cgaccagcac gcacgaggtg
      901 cggtcggtcc agtcggtgac ggcggacatc ttgtcggcgc cgatcaccag ggcctgccgg
      961 gcgctgccgg cgcggacggt ggcgtcggcc agggcgaggg cgtgcgtgaa gccggcgcag
     1021 acgacgttga cgtcgagcac ggcgggcgag ggcatcccga ggcgcgcggc gacgcgggcg
     1081 gcggtgttgg gcgagcggtc gacggccgtg gaggtcgcga cgatgaccat gtcgacggag
     1141 ccgggggtga gcccggccgt cgcgagcgcc ttcgcgcccg cgtaggcggc cagttcgtcg
     1201 accggttcgt cgtcgctcgc gatgtgcctg gtcctgatgc cgacgcggga cgtgatccac
     1261 gcgtcgttgg tgtcgaccag ggcggcgagg tcctcgttgg tgagcacccg gcctggctgg
     1321 tagtggccga gcgcgacgat ccgtgaaccg ttcatggggg tcttgccctc cgtagccgtg
     1381 agacggattg ttccagcgtg atcacttacc cacgggtacg gaggtgggta aagcgacagg
     1441 attcgggcga cgggcttgga gagttcgccc agaaccagga ggcgccaggg gcgtacgggg
     1501 tgagctgggg gcgcgaagga gtgcggcacg cgccggttcg cttccggtgc cggggacgcg
     1561 cgtccgggcg cggggattcg cgcccgtcgc ggtgacgcgc gtcccgttgc gtaggcgcgc
     1621 gtcccgtcgc ggtgacgcac gtcccgtcac gtaggcgcgc gccccgtccc gccccatccc
     1681 ggtgagacgt ttgcgttctt cccggccgcc ggtctacggt gaggcgcgtt gagaacgcga
     1741 gcgtttcttc tgtgggggtc gtggtgagcg aggagtccgg ggagggtgcg cgtcccgccg
     1801 gggcacggcc cgccgtgcgg cgtccccggc tcacccccgc gcgggaggac gagttcctcg
     1861 acgcggccct cgcggtcgtg cgggagaccg ggtacgaggc cctgaccatg gaaggcgtcg
     1921 ctgcccgcgc ccagtgcggc aaggcgacgc tgtaccggct ctacgggagc aagcagcgac
     1981 tcgtggccgc ggccgtctcg cggacccgtc ccgcccaccg cgtcccgctc gacacgggtt
     2041 cgctgcgtgg cgacctgctc gccgcggcgc ggcgcgcggc ggccgagttc gaggactcga
     2101 ccacgctggt ctgggcggtg gcgcacgcct ccatcgagga ccgggccctg cacgacgcgc
     2161 tgcggctcgc gttcatcgac ccggaggccg ccgacctgga cgccaccgtg gaccgggccc
     2221 tggcgcgcgg cgagctgtcg caccgcccgg ccgccgcgcg gcacctggac ggcctcctgt
     2281 tcggcgccgc cctggtgcgc agtctcgacg gggagaccgc gccctcgggc ctcgaagccc
     2341 tcgtggacga cgtgatcctc ccggccctgc tgcacagctg accggcccgc ccgctccccc
     2401 tccgggagcg ctcccgcgct ccccggctct ccctcccgga agagtcccct ccctctgcaa
     2461 ggaagtaccg catgtcctcc cccgccaccg gcgctccggc acgtcccgga gcagccggta
     2521 ccgccgggtc cgctcccggc cccgtgccgc accgctggct gatcatggtc ttcatctcgg
     2581 cggcccagct catggtggtc ctcgacgcga cgatcgtgaa catcgcgctg cccaccgccc
     2641 agctcgacct cggcttctcc gacgccgacc ggcagtgggt cgtcacggcc tactcgctcg
     2701 ccttcggttc gctgctgctc ctcggcggcc gggtcgccga cctcttcggc cgcaagaacg
     2761 ccttcctgat aggtctcctc ggcttcgcgc tcgcctccgc gctcggcggc gccgccagca
     2821 gcttcgaggt cctgatcgtc gcgcgcgccg tgcagggcct gttcggcgcg ctcctcgcgc
     2881 ccgccgcgct ctcgctgctc acgacgacgt tcaccgaccc ggccgagcgc ggccgggcct
     2941 tcggcatctt cggcgccgtc gccggctcgg gcgccgccct cgggctgctc ctcggcggtc
     3001 tcctcaccga gcacctgaac tggcgctgga cgctgtacgt gaacatcgtc ttcgcggccg
     3061 tcgccttcac cggcggtctg ctcctgctgc gccgcacggc gcgggaccgg acgaagaagc
     3121 tcgacgtgcc ggggacgctc ctcgcgagcg cggggctctt ctgcctcgtc tacggtttcg
     3181 cgcacgccga gacgcacgcg tggtcctccc ccggcacctg gggtctcctc ctcgcgagcg
     3241 tcctcctgct cgccgccttc tgcttctggc agacgcgcac cccgcacccg ctcctgccgc
     3301 cgcgcatcct gctgcaccgc gaccggggcg ccgcctacgt cgcgatgctc gtcgcgggcg
     3361 cggcgatctt cgggatcagc ctcttcctga cgtactacct ccagcaggtc ctggagctgt
     3421 ccccggtgcg gaccgggctc gcgttcctgc cgatgagctt cgccatcatg gtcacggcga
     3481 cgacgggcgc gagcgtcctg ctcccccgtt tcgggccgaa gctcgtcgtg agcgcgggaa
     3541 tgctcctcgg cggggccgga gcgctgtggc tgtcgcggct ggacgtggac agttcctacg
     3601 cggggcacgt gctgccgccg ctgatcatcg ccgggctggg catgggcgcc gtgatggcga
     3661 ccgcgatgag ccaggccacg gcgggggtcg cgcacagcga cgcgggcgcc gcgggcgcgc
     3721 tcgtcaacac gatgcagcag gtcggtggtt cgctcgggac ggcgctgctc aacacggtcg
     3781 tcgcgagcgg cgcggccgac tacctcgccg cgcacgacgc gcgcgagccg ggggcgcggc
     3841 tcgcggccgg tgtgcacggc tactccgacg cgtacgtctg gacggcggtg ttcttcgccg
     3901 cgggcctcgt cgcggccggt ctcctcttcc ggcgccgtcg cacgcaccgc gccggggagc
     3961 ggccggcgcc cggtcgtcca cgtgtgagnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4081 nnnnnnnncg gccccctccc cgtaccgccg tcccggcggc cgtggcaggc tcgtacccgc
     4141 gtgccgccgc cctcgccggg cgggcgggca ccacgactga ccggtacgga cgggaaaggg
     4201 cggccgccca tgggacgcgt gacggaacgg cggcgggtca cccgcgtacg ggcgggcgtg
     4261 gtctcggcgc gcccggacac gctcgtcgcc gaggaacccc tcgaaatccg gctcgcggga
     4321 aaacctctgg ccatcacgat gcgcaccccc ggcgacgact tcgcgctcgc cgccggtttc
     4381 ctcgtgagcg agggcgtcct cgcctccgcc gaggacgtgc ggtcgatcgt gtactgcgcc
     4441 ggggcgaccg acgacggctc gaacacgtac aacgtggtgg acgtccagct cgccgagggc
     4501 gtgcccctcc ccgatttcac gctggagcgg aacgtctaca cgtcctcctc gtgcggcctg
     4561 tgcgggaagg cgagcctgga cgcggtccgt acgacgaccc gcttccccct cgccgacacc
     4621 ccgccgccgc gcctggcccc cgcgctcctg tccgccctcc ccgaccggct ccgcgcggcg
     4681 cagcgcgtct tcgaccgcac ggggggcctc cacgcggcgg cgctcttctc cgagaccggc
     4741 gaactccccg acatccgcga ggacgtgggc cgccacaacg cggtcgacaa actcgtgggc
     4801 cgcgccctca ccgacgcccg cctccccctc tcccgcgcgg tcctcctggt cttagaagcc
     4861 atctcatttg ggtgactcgg tagtctatga gtcatggtgg ggcttgttga gcggctggtg
     4921 ccggacgaat tgtggcagtt gttccagcgg gtggtgcctg aggcgccgtc gcggccgcag
     4981 ggtggtggtc ggcgtcggca cggtgaccgg gaagtgctgg ccgcgatcgt cttcgtggcc
     5041 acgtcgggtt gtacctggca gcagctgcct tcggcgtcgt tcggcccgtc cggagcgact
     5101 gcccaccggc ggttctcgga gtggtcgaag gccagggtgt gggccaagct ccaccgcctg
     5161 gtcctcgacg agctcggtac gcgcggggag ctggactggt cgcggtgcgc gatcgactcg
     5221 gtgaacatgc gggccttgaa aagggggacc tgacaggtcc gaatcctgtc gaccggggca
     5281 agtacgggtc gaagatccac ctgatcaccg agcggaccgg tctgcccata tccgtcgcaa
     5341 tctccggtgc caacgtccac gacagccaag cccttatccc gctcgtgaag ggcataccgc
     5401 ctatcagctc ccgccggggc ccccgtcgac gccgacccgg aaagctccac gccgacaagg
     5461 gatacgacta ccgccacctg cggcaatggc tgtccggacg cggaatccgg catcgcatcg
     5521 cccgcaaagg cgtcgagacc tcgcagcgac tcggccgaca ccgctggacc atcgaacgca
     5581 ccatgtcctg gctcgccggc tgccgacgac tccaccgacg ctacgaacgc aaagccgacc
     5641 acttcctcgc cttcaccagc atcgcctgca ccctcatctg ctaccgcaga ctcaccaaat
     5701 gagatgactt cttaggccgc gcctccttcg agctggccca gaaggcggcg atggcgggca
     5761 tcccggtcct ggcggcggtc tcggccccgt cctccctggc ggtggacctg gcggcggaga
     5821 cgggcatgac cctggtcggc ttcctgcggg gcgagtcgat gaacgtgtac gcgggccagg
     5881 agaggctggt gctggagggg gcggaggtgt gaccgccgcc ccggcggtcg ggaccgcgtg
     5941 ccccgggccg tacgaaggcg ccgccggccc gtgccccggg ccgtaggaag ctccccgtca
     6001 gcccgcgccc cggcggtcct tctcgcgcga gggcttcggc tgggggcggg gtgacgggac
     6061 cgtcgccccg ggggccgggc ggtccgcgcg cggtgccgtt gccggggaga tcgctgccgc
     6121 gaggagcatc agggccagga ccgggagcat cgccgttcgc aggccctcgt ggtcgccgag
     6181 gaagccgagg cacgggggcc cgccaggagg gccacgtagc cgatgcggga ggtgagcgcg
     6241 acgcgggccg ccgtgtccgg gcccgatgcg cccgccgccg agagggccag cgggaagccc
     6301 agggaggtgc cgaggcccca caggaggacc gcgcagcccg ccgtcgccgg gttgtccacg
     6361 aaggagacca gggcgatgcc caccgccgtg aggagtgctc cggcgcccag gaccttcgcc
     6421 cggccgaagc gcgtgaccac cgggcccccg gcgaagcggc ccgccgccat cgtcgccgcg
     6481 aaacccgtgt acacgagcga gccgagcccg gcgggcatgt cgtggccgtc gaccatgagg
     6541 agcgggagcc agtccgtcgc ggcaccctcg gccagggtca tgccgaagac gacgccgccg
     6601 atcaggagca gtcgcgggtc gaggtacagg cgccgttccc gcgccgcccc tgcatcgtcc
     6661 gcgcgcgagg cgccgatgcc gggccgcagg cccgggatcg cgtacgcgaa gagggcgagc
     6721 acgaggagca ggacgagggc caggtgccag ggcacgggga agccgaccgc cgcaccggcc
     6781 acgccgagcc ccgcgcccac caccgtgccg aggctgtagc agccgtgcat cgcgggcagg
     6841 accgggcgcc tgagctgccg ttcgacatgg acgcccgcga cgttgctggc cacctccgag
     6901 agccccaccc cgcgccgatg agcaggaggc cgcaggccac gaggagcgcc gcggacatcc
     6961 ccgtgccgag cgccacgacc ccgacccccg ccagcacgag cgtcatgccc gcgatgacga
     7021 cggggcgggt cgcgtaccgg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncgg cacggcggcc ggctcgcccg
     7441 cgcccgccgc ctccggtgcc gcctgcgccg cgcgcctgcg ggcgatcacc gcgcacacca
     7501 tgagctgcat ctggtggaac accatcagcg gcagcaccgc gagcgaggtg tgggcgccga
     7561 aaaggacgct cgccatgggc aggccggagg cgagggactt cttcgagccc gcgaactgga
     7621 tcgcgacgcg gtcggcgcgc gggaagccga ggcgccccgc gccccaccac gtgaggccga
     7681 gcatcgcggc gaggaggacc gcctcggcga ggagcagggc gagcagccgc ggcacggtga
     7741 cctggtgcca gatgccgcgc accatgccct cgctgaacgc cgtgtagacg acgaggagga
     7801 tcgagccccg gtccacgtac cccagcacct tcttgtgccg ggtcaggaag ccgccgaccc
     7861 agcggcgcag gaactggccc gcgaggaacg gcaggaggag ctggacgacg attctgccga
     7921 gcgaggccgc cgagaagccg ccgccgctgt cgccgaggag cacggcggcg agcagggggg
     7981 tgaggacgat gccgaagagc gaggagaagg agcccgcgca gatcgcggcg ggcacgttgc
     8041 cgcgcgcgag ggaggtgaag gcgatcgagg actggatcgt cgagggcacg agggtgagga
     8101 agaggaagcc ggtgaagaga tcggggctca gcagccaggg gcgcagcgtg taggcggcga
     8161 ggccgagcag cgggaagacg aggaacgtgg cggcgaggac ggtgacgtgc agccgccagt
     8221 gccgcagccc gtcgagcgcc tcggcggtgg acaggcgcgc cccgtacagg aagaagagca
     8281 gcgccacggc ggccgtggac gcgcccgaca cgccgctcgc gacgccgccg cgcgcgggga
     8341 gcagcgcggc gagcaggacg gtgccgagga gcgacaggat gtacgggtcc agcgggagcc
     8401 gggggcgttt catggcgggg ccgtcctcgg ggcgtacggg gaggtggggg cgccatcgat
     8461 cgtgccgcac cgggccgctg atcgggaacc ccgtacaccg ctctgactgt tatcgcggcc
     8521 gacgatgacc gcgactacac tcccccaccg tgtacgagcc ctcccacctg cgcaccttcc
     8581 tcaccgtggc gcagacactg agcttcacgc gggccgcgca gcggctcggg gtgcggcagt
     8641 cgacggtgag ccagcacgtg cggcgcctgg aggagcagac cgggaggccg ctcttcgtcc
     8701 gggacacgca ctcggtcgcg ctcaccgagg acggcgaggc gatgctcggc ttcgcgcggc
     8761 gccttctcgc ggtgcaggag caggcggtgg cgcacttcgc ggggacgcgg ctgcgcgggc
     8821 ggctgcgctt cggggcctcc gaggacttcg tcctgacgcg gctcccggag atcctggagt
     8881 ccttccggcg ggcgcacccg gaagtggacc tggagctgac cgtggagctg tcggggacgc
     8941 tccacgagcg gctcgccgaa gggcgtctcg atctcgtgct cgccaagcgg cgggccgagg
     9001 agacgcacgg ggtgctggtg tggcgcgaca cgctcgtgtg ggtcgcgggc gagcggctgc
     9061 ggctggacgc ggagcgcccg ctcccgctca tcgtgtaccc gccgcccggc atcacccgcg
     9121 accgggcgct gcgcgtgctg gagcgcgagg gccgcgcgta ccgcgtcgcg tgcacgagcg
     9181 ggagcctcaa cgggctcgtc gcggcggccc gcgcgggcct cggggtcatg ccgcacgcgc
     9241 ggggcctgat cccgccgggc ctggtccggg tccccgagcg cgcggggctg cccgcgctgg
     9301 gcgacgtcga tttcgtcctg gtccacgacg accggcgcgc ggaggcccgg gagccggggc
     9361 gggcgctcgc ggaggcgatc ctggcgagcg gggaccggct gcacggtgcg tgaggggcgg
     9421 cggggcgggg cgaccggcag ggcggtgtga catataccgg ccatgcggac agaggtggcg
     9481 gaagacggta cggggacggg cggcgggccc ggtctcgcgg agtgggcgct gcgcgccgtc
     9541 ggcgcggcgg atctcgacgc gctcgtggaa atacgggccg aggtcatgcg cgcggacctg
     9601 gagcgcctcg ggcgctacga cgagcgccgc gtgcggcgac ggatgcggga ctccttctcg
     9661 ccggcccaca cctcggtgat cctcagcggc ggggcgctcg cgggctgcgt caccctccgg
     9721 cccgccgagg acggcggcca ctggctcgaa cacttctacc tcgccccgcg ccaccagggc
     9781 cggggcctcg gcggcgccgt cctgcggtcg ctcctggagc gcgcgaacgg gcggcccgtg
     9841 cgcctgcacg tgctgcgcgg cagcgccgcc cagcggctct acgcccggca cgggttcgcc
     9901 gtcgaggacg agggcccggt cgacgtactg atggtccggc cgccgggtgt cgcggggccg
     9961 ggggccgccc ccgcgacgcc agggacggcc ccgcgacggc tcagggctga acgaggcgga
    10021 cccggtcgac ccccatcagg ccggtgagcg gcacgcgggc gacgcgctgg cgcggatcga
    10081 cgaccagccc gctggaccgg atcatgtcga ggagcatttc ggcgaggggc atgaccatgt
    10141 gccggcccca gcagcgttcg gacgaatgcc cgaaaggcag gtatccgggc gtgcgttcgg
    10201 ggtccttttc ctcccagcgt tccggccgga attcctcggg gttttcccac agcgcgggat
    10261 cgcggtgact gaggaaaggg agcacgagaa catcgtcggc gggcgtgatg cgggcatcga
    10321 tcgccgggta ttcgggcgag gaattgcgca ggatgttcca ggagggcggc agcaggcgca
    10381 gcgactcgtg gacgaggtgg cggctcggga tgtccgggtc gaagggggct ccgagccaga
    10441 gggcgttggc gacgagggtc gagatcgtga agcacaccgg ggcggcggtg cgccggtaga
    10501 ggcccatcgc gtaccggcgc tcctggtacg tgccggcctc caggccgagc gcggcgagcc
    10561 gggtcgtgcc ggtgcggcgg cgcggcgcgg ggagggcggc cccggcggcg atgacggtcc
    10621 aggtgagctt cggcgtcagc tccatggcgc ggttcatcag cacgcgcagg cggcgcgggt
    10681 ccccgccgag gatcaggtcc cggaggtaga cgtggccgac gtggggccac aggccggaga
    10741 ggtcgggatc gcgcggcgcc tcgcgcttga gggccgcgcg cacgtcgtgg ccgacggcct
    10801 gcatctgggt cgccgcccgc tggtgcggga tcgcgcggcc gagcaggggt ttgaaggtgg
    10861 ggcgttcggt cttgccggcc gggcgggcgg cgagcacgcg gtccaccagg gcgggcccgg
    10921 cgatgccgac cgtgtcgggt tccgggcgga agaggtccgc gccgaggtgc tcgcggagca
    10981 ggttgtcgag gggcggcgcg aagaggatct tccgctccgg ggcgcgcgtc ggggtgtggg
    11041 acgtcatccg tgcgactcca gaagaccggg agggcggcgc ccggcggggg tccgccgccg
    11101 ggcgccttcc cggctcgaag gtgcgctccc gggaaggaga acgcggccga ggggggatca
    11161 gtaccagatg taccaggcgt gggccttcag gctcttctgc tgggacagct tgttcttgag
    11221 cgagaaaagc agccgcattt tctttccttc tttccgggtg ggacggtgga ggaaaacagc
    11281 gcgctttccg gtcgatcgat cggattcccc ttcggcgcgc cgatgatcag tgaagaccag
    11341 cgattgatgg cctgtcaacg ctcccgggaa gaacgtgaca cagggggcct cccccggcct
    11401 tttcgcgggt ccgcctgtcc gaaaaagcgc gccggggttt atccagcggg cgcggcgggg
    11461 agaggtggcc gcgcccgagg cggcgaggag cccgtctgac gccctctcac ctgcggaaac
    11521 ccgtgcggct tcggtacaga ttccgtggag gaggaccgcg cggcgcttag aagccatctc
    11581 atttgggtga ctcggtagtc tatgagtcat ggtggggctt gttgagcggc tggtgccgga
    11641 cgaattgtgg cagttgttcc agcgggtggt gcctgaggcg ccgtcgcggc cgcagggtgg
    11701 tggtcggcgt cggcacggtg accgggaagt gctggccgcg atcgtcttcg tggccacgtc
    11761 gggttgtacc tggcagcagc tgccttcggc gtcgttcggc ccgtccggag cgactgccca
    11821 ccggcggttc tcggagtggt cgaaggccag ggtgtgggcc aagctccacc gcctggtcct
    11881 cgacgagctc ggtacgcgcg gggagctgga ctggtcgcgg tgcgcgatcg actcggtgaa
    11941 catgcgggcc ttgaaaaggg ggacctgaca ggtccgaatc ctgtcgaccg gggcaagtac
    12001 gggtcgaaga tccacctgat caccgagcgg accggtctgc ccatatccgt cgcaatctcc
    12061 ggtgccaacg tccacgacag ccaagccctt atcccgctcg tgaagggcat accgcctatc
    12121 agctcccgcc ggggcccccg tcgacgccga cccggaaagc tccacgccga caagggatac
    12181 gactaccgcc acctgcggca atggctgtcc ggacgcggaa tccggcatcg catcgcccgc
    12241 aaaggcgtcg agacctcgca gcgactcggc cgacaccgct ggaccatcga acgcaccatg
    12301 tcctggctcg ccggctgccg acgactccac cgacgctacg aacgcaaagc cgaccacttc
    12361 ctcgccttca ccagcatcgc ctgcaccctc atctgctacc gcagactcac caaatgagat
    12421 gacttcttac tccgcactcg gcgattcccc gcgattctcc tcaccgcctg tccccctgcg
    12481 ccccggttgg ggcgggttcc ggggcgggaa gggggcatat gcgggcggga ccggcaccgc
    12541 gcgagggctc ccccggtggg gcttacctgc ggtagcgtct cggcgccgta cccccgcacc
    12601 agcccggcgc gggggtgcgc ggcggcacga ggagcagctt tgcgcgagtt cagtcagccc
    12661 ccgctgaccc gggcgcggcc ggtgggcggc ctcgccgact gtgtcttcga ccacgcgatc
    12721 gaggacccgg aacgcgtcgt gctcgcgcgc aagagcggcg ggcgctggga ggacgtgacg
    12781 gcggcgggtt tccgcgacca ggtgctcgcg gtcgcgaagg ggctgctcgc cgagggcatc
    12841 cgcttcgggg accgggccgc gctcatggcg cccacgcggt acgagtggac gctgctcgac
    12901 ttcgcgctgt ggacggtggg cgcgcaggtc gtccccgtgt acccgacctc ctcggcggag
    12961 caggtgttct ggatgctcca cgacgcgcag gcggccgccg cgttcgtgga gcacgaggac
    13021 cacgcgatga cggtcggctc ggtcatcgac cgccttcccc acctgcgccg cctgtggcag
    13081 ttcgacgcgg gcgcggagca ggagctgatg gcggcgggcg ccggtctcgc ggacgaggtg
    13141 gtgcaccggc accgccggcg gtcacgccgg actcggtcgc ctcggtcatc tacacctcgg
    13201 gcacgacggg ccgccccaag ggctgcgtcc tgacgcacgg caacttcatg ttcgaggcgg
    13261 acacgctgct cagcgcctgg tcgcgggttt tccagccgca ccgcggcgag gaggcgtcca
    13321 cgctactctt cctgccgctc gcgcacgtct tcgggcgggt cgtggaggtg gcggcggtgc
    13381 ggggccgggt gaggttcggg caccagccgc ggctgcgcgc ggaagcgctc gtcccggagc
    13441 tgatggcgtt ccggccgacg ttcgtcctcg ccgtcccgta catcttcgag aagatctatc
    13501 gctcggcggc gcgcaaggcc gaggcggagg ggcgcggcgg ggtcttcgcg aaggccgtgg
    13561 aggtcgcggt gcggtacgcg gaggcgcgcg agcagcgggc gctggggcgg ggagccgggc
    13621 cgggggcgca gctccggatg cagcaccagc tctacgacaa gctcgtctac gcgcggctgc
    13681 gcgcggtgct cggcggccgg ctgcggtacg cgatgtcggg cggttagggg atggaccgca
    13741 ggctcgggct gttcttcgcg ggcgcgggcc tgacggtgta cgaggggtac gggctcaccg
    13801 agtcgagcgc ggcggcgacc gcgaacccgc cgggccgggc ccgcttcggc acggtgggcc
    13861 tgccgctgcc gggcacctcg gtgcggatcg cggcggacgg ggaggtgtgg ctgcgcgggg
    13921 agcacgtctt ccagggctac ctgaacacgc cgcgcagcgg gcacacggcg ctgcgcgagg
    13981 gctggctcgc gacgggcgac ctggggcggc tggacgagga cgggtacctc acgatcacgg
    14041 gccgcaagaa ggagatcctc gtgacctcgg gcggcaagag cgtgtcgccg gggccgctgg
    14101 aggaccgggt gcgcgagcac ccgctcgtgg cgcagtgcgt cgtgctcggc aacgaccggc
    14161 cgtacgtctc ggcgctcgtc acgctggacg aggaggcggt ggcgcactgg ctggagatgc
    14221 gcggggagcc gccgcgcgag cccgccgcgc tggtgcgcga cccggagctg gagcgggagg
    14281 tgcggcgcgc ggtcgtcgcg gcgaacacgc aggtctcgca ggcggagccg atccgcacct
    14341 tccgtatcct ggcccgcccc ttcaccgagg agcagggcct gctcacgccc tcgcccaagc
    14401 tcaagcgcaa ggccatcgag gaggcgtacg cccgggagat caccgcgctg taccggggct
    14461 gaggcccgca cggcgtcccg ccgccccggg aacacgtgcc cgtgggcacg tcgttaaggt
    14521 cggtgagtac gtccggtacg ggccgggcgg ggcgcgcggc gcgaacgccg ggccgtgccc
    14581 gtacggccct atgagcgctt aaggatcgac agacgcagtg agtgcgcaca aggtggttcc
    14641 cccgatcgtc ctgaacaacg gcgtcgagat gccccagctc ggtttcggtg tgtggcaggt
    14701 gcccgacgag gaggcgacga ccgccgtcgg gctcgcgctc gacgcgggct accgctcgat
    14761 cgacacggcg gcggtctacg gcaacgagcg cggtacgggc aaggccatcg cggcctcggg
    14821 gctcgcccgc gaggaactgt tcgtgacgac gaagctgtgg aacggcgcgc aggggtacga
    14881 cccggccctg cgtgccttcg acgcctccct cgacaagctc ggcctcgact acgtggacct
    14941 gtacctgatc cactggccgt gccccgcgaa ggaccgctac gtggacacgt ggcgcgcctt
    15001 cgagaagctc ctcgccgacg ggcgcgtgcg cgcgataggc gtctccaact tcacgcccgc
    15061 gcacctggag cggctgctcg gcgagacctc ggtgatcccg gcggtcaacc agatcgagct
    15121 gcacccgcac ctccagcagg gcgaggcccg cgccttccac ggcgagcagg gcatcgcgac
    15181 cgaggcgtgg tcgccgctcg gccagggcaa gggcctcctg gaggtgcccg cgctcgtggc
    15241 gatcggccag aagcacggcc gcaccccggc gcaggtcgtg ctgcgctggc acgtccagct
    15301 cggcaacgtg gtgatcccga agtcggtgac gccctcccgc atcaaggaga acatcgacgt
    15361 gttctccttc gagctggacg aggaggacat ggccgcgatc cgcgccctca acgaggagca
    15421 ccggctcggc ggccacccgg acgaggtcaa ctgacccgct cgcgggggcg gtgacacgca
    15481 ggggacgcgc ggggcacacc gggcgtcccc tcggtcgtac cgcgggggca cggtgtgcgg
    15541 gcctgggccc ggggggcccg caccgctcag ccccggcccg gtccgccctg ctcagccccg
    15601 gttgcgcttg cgcagcgcga gcagcgtgta gaccgggtcg cggcgcggcg tgccgggatg
    15661 gggcagcgct tcgaggcggc gggtcagttc ctcgcctccc ggcacgtaca gaccgccttc
    15721 gcgcacgcgc gcggcggtct cgcgcgggct gcgtgccctg accgtgcccc gtgaagcggg
    15781 cggagccgtg cgggcgcagg tcgtgcgcgg cggcgagcgc ggtcacgcgg cccgcgccgt
    15841 ccgggagttc gacggggcgg tagggggcga gcagcgcgtc cgtgtcctcg ccggccgcgt
    15901 gtgcggccga tttgtcgacg gtcgtcacga agaggccgcc ggggcgcagg acgcgcgccg
    15961 cctcggcgac gaagggcgcg gcgtcctcga ccaggttgag gagccagacg gcggtgatcg
    16021 cgtcggcgct gcccgaggcg aagggcaggg cgcgcgcgtc ggcgcggacc accccgtcca
    16081 ggcgccccgc cgccttctga agcatcccgg cggagaggtc cacgccgcgc acggtgaacc
    16141 cggcctcgcg caggcagccg ccgacgatgc cggtgccgca ggcgaggtcc acgacggtgc
    16201 gggtacggcg cggcaggagc ccggcgaggg cctcggcggc ggcccgggcg cgcgggaggc
    16261 cgcccctgct ctcgtcgtag cgggcggcct cctcgtcgta gtcgagcatt ctcagccccg
    16321 cgccccgtgg gcggcggaca gttcctcgac gcggcgcgcg agcgtgacgt cgagcgcggt
    16381 gatcctcccg cccgcgctgt gcgtgtgggt ggcgacctcg acggtgttgt agccgagggt
    16441 gaggtcggcg tggtggtcca tctcctcctg caccgaggcg atgtggagca cgagagcggc
    16501 ggcggcgagg tggccgggga ggcggtagaa gcgcgtgagg cggtcgtcct cggcgctcca
    16561 gccgggcagg gtggcgaggg cggtgccgat ctcggcggcg ggcagcgggc gggcggcggg
    16621 caaggctgct cctcgggggg ggtacgtgcg gccggggacg ggccggttga tgccggctca
    16681 ggctaccggc cggtccgcgc gggcgggcgc gcgggcacgc ggggccgccg ggtgacgccc
    16741 gcccggggcg atccgccctg gcgccgggtc aagacttcct tttggtctag tccaatccat
    16801 tgacgtgttc tctacaacgg cgggacagtg aggcgcttcc tcaccccctg ggagatcccc
    16861 atgagacgtc ttcgtgccgt cctgtgcggc gccgccgcct ccgcgctcgc ggcggccggg
    16921 ctcaccgcgc tgctgcccgc ctcggcctcc ggcgccgaga gcgccaccct ggacaagcgg
    16981 tggtacgccg ccgcgcccta cctcatgccg ctcgacaacg acccgcccag cgccaccgcg
    17041 atcatggacg cctccgggct caaggcgttc cagctcgcgt tcatcctcgc gccgaacggc
    17101 ggcgggtgca gcccgacctg ggacggcacg gcgccggtgt cctcggacac cgccgtcggc
    17161 tccgtcatca gcgcgatccg cgccaagggc ggggacgtgt ccgtctcgat cggcggctac
    17221 ggcggcacca agctcgggca gagctgtacg gacgcggcgt ccacggccgc cgcctaccag
    17281 caggtcatca ccaagtacca gctcaaggcc atcgacttcg acctggagga gcccgagtac
    17341 gagaacactg cggccatcgc ccgcgagatc ggcgccgcga agatcctcca gaagaacaac
    17401 ccgggcctgt acgtctcggt gacgacggcc gggacggccg acggcaccgg ctggttcggc
    17461 aagcagatgc tcaacgaggc gaaggcgcag ggcttcacgc ccgacaactt ctcgatcatg
    17521 ccgttcgacg gcggcttcaa cggggcggcc tcgcagaccg ccgcgctcac cgccttcaac
    17581 ggggtgctcc gctcgacctt cgggtggagc gaggcgaccg cgtacgcgca cgagggcttc
    17641 tcgggcatga acgggcgcag cgacacgggc gagtacttcg gccaggccga cttccagacg
    17701 gtcctggact acacgaccac gcacggcatg gcccgcttca ccttctggtc cctcaaccgc
    17761 gaccggcagt gcagccccgc cgacaacggt ggcaggacca gcgggacgtg cagcagcgtg
    17821 ccgcagtccg cgtgggactt cgccaagttc tccgtgaagt tcgcgggcgc caccccgccc
    17881 gccaacccgc cgaccgaccc gcccaccgac cccggcaccg ggcagtgcgc ggcgggcgcc
    17941 tggagcgcgg gcgcggtgta cgtcaagggc gacaaggtca cccaggacgg ccacacctgg
    18001 gaggcgaagt ggtggacgac gaacgagaag cccggcacga cgggcgagtg gggcgcgtgg
    18061 caggacgacg gcccctgctg agcgcggcct gagcgcgacg gggcggtttt tttttttttt
    18121 ttggggggcg gccccgcccc cggggcgtcc ccgcccctca gtgcccgtgg tgcgcgtgga
    18181 ccaccgcgtg ccccttgccc cggccgatca tccagcggtt gaccggtgtc gtgacgagga
    18241 aggcgagggc gagggagccc gcgagggaga gccagaacag gaggtcggcg aggccggcgt
    18301 ccatcgcgcc ggggaccgcg accatcgcgg tgttgtcgat cagttccatg accgcgatcg
    18361 agaccgtgtc ggcggccagc gcgaccttga aggcggcacg ggggcccagc ccggcgcgca
    18421 ggacgccgcg cgccgtgagc gcgtagccga agacgaaggc gagcacgatc gacagggcga
    18481 cggtcgcgcc gttgtggaga ccggcggccg tcccgatgac catgccgagg atctcgccga
    18541 tcgcgcaccc ggtgagacag tgcagggtgg cccgcgcggc catcgaccag ggcgtgccgg
    18601 accagccggc gggacccccg tgcggggcgg ggcggtctcc gtggtgcgcg tgatccatcg
    18661 cgctccccct tccgtgcgtc gtcagcggcg gcttttcgac gggagaacac cgtacccccc
    18721 cggggtattc cccagggggg gtatggcggc ccgcgtcagc gcttgacggt cacgcgtgcc
    18781 tcggcgcgta cgccggagac cgtcaccgtc agcgcgaccg tccccgggcg cagtgccgtg
    18841 agccgtcccg tcgcggtgtc tccggccctg tcgcgcgnnn nnnnnnnnnn nnnnnnnnnn
    18901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnccgggc gcgaggcgcg
    19021 cgggggcgtc gagccgcagg ctgtcggtgt gcgggcgggt ctggacgccg agccagccct
    19081 ccgggagcgc ggcccccggc cgtgccgcgc ggtccacgcc gaggaggctc cagccggtga
    19141 agccacccgc gtcggcgggc gtcgcggggt tcttcccgga gttcccgttg accaggtacg
    19201 ggaccccttc ggcgtgcgag gcgtcgaagg tgccgacgtg tccggcgacg tacgcgacgc
    19261 ccttgccgct cgtgcgccgg aagtccgcga gccacgactc gaccagcgcg gcctccttgc
    19321 ggtcgccgag ctggctgccc ttctgcgggg tcgggtcgcg cggcggtacg tgcgcgacga
    19381 cgaccaccga gccgaccgcg cggtccttcg cggcggcgtc gagcgcggcg cgcaggcggc
    19441 cgagctgcgc gaagtccgag acgcgcagcc cgagcccgga ggtgtccagg gtgaggaagc
    19501 gggtgccctt gtggtcgaag gtctgctccg ccgcgccgaa ctccttcgtg aagtgggcga
    19561 tcgagccgcc catcacctcg tggttgcccg gaacgtagtg ccagggcacg gcgtcgccca
    19621 gttcctcgtc cagcatccgg tgcgcgaagg ccaggtcctc gggcgaaccc tcgtccacga
    19681 ggtccccgtc gatgatcagg aagtccgggt ccgccgcccg gacctcgcgc agcgtgcgcc
    19741 gcgcctgcac ggcgttctcg ccgtcgggct cccgcgcgac gaactgcgcg tcggacatga
    19801 cggcgaaccg ccagtccctg ccccggacgt cgcgcgcggt cgagatgagc gggtcgtggg
    19861 ggcgggcgct cgcgggcagg tccaccgccg ggggaacctg cgcggtgagg ccgtcgagtt
    19921 cgacctcgcc ccggtactgc ttcgtcgcgt cggtctcggc gaggtagaag cggacgaggg
    19981 agacggggtg ggcgacggac tgcggcacgg ggaaggtgac cttcttccac ccggtccagt
    20041 ccacgtacgg gccgcgcagc aactggtcag tgccggtcgc gtccttgagg tgcagcgtcg
    20101 cccaggcgcc gtgcccgtcg cccttgagcc acagcgtgaa cgcctgcggc tgcccggcga
    20161 cggggagcgg ggcgggcggg ctcgcgtagg cggcgcgggt cgcggtggac cgcgtgaagt
    20221 cgtacgtcac gcgcagcccg gtgccgtcgt ggctgtccga aacggcggtg agcgcaccgg
    20281 cggcgcgggc ctggctgaac gtccagtcgg ccgcgtcgtc gaagccggtg acggcccggt
    20341 cggtgagccc ggcggagacg gcgagggcgg tggagtgccc ggcgaccgtc gcggtgacgg
    20401 tgcccgccac gccctccgtg cgcgccctga cggtgaatcc gtcggcgtcg ggggtgaggg
    20461 tgaacaggtc gtggtcgtag gtgagccgga cgtcggtggg ctcgacgggg gcgctgccgc
    20521 cctcggcatc gaagccggtg acgccgaagc gggcgctcgc ggcggcgtcg gggagcgcga
    20581 ggcgccgggt gccggtgtcg acgcggtcga gggggccgag gacgggagct tcgtggagcc
    20641 ccacgcggcg cccctgcggg cggtgacctc cgcggtgccc cgcgcgcggg gcgcggtgta
    20701 gcgcccgtgg cggtcgacgg tgcccccgcc gcgcaccgtc cacgccgggg tcccgggcgc
    20761 gggcccgtac gtctcgtcgt ggcccccggc ggtcagcgcg cggtgcagcc cggggaacac
    20821 gcggtcgggg tggcccccgg tgacggggtc ggcggtcggg gcgccgagcg ggtccatcgc
    20881 ggtgcccacc cggtacccgg tgaggcggcc cgagccgtcg ggggcggtga ggatcaggcc
    20941 gttggggacg gggcgttcgg tgccgtcgga gggctggttg ccgacctgga gggtgtcggt
    21001 gccgggggtg cgggcgagga gggtggagga gccgccgccg tcgaggt
//
