LOCUS       NC_013928              22499 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptococcus mutans NN2025, complete sequence.
ACCESSION   NC_013928
VERSION     NC_013928.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans NN2025
  ORGANISM  Streptococcus mutans NN2025
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Maruyama,F., Kobata,M., Kurokawa,K., Nishida,K., Sakurai,A.,
            Nakano,K., Nomura,R., Kawabata,S., Ooshima,T., Nakai,K., Hattori,M.,
            Hamada,S. and Nakagawa,I.
  TITLE     Comparative genomic analyses of Streptococcus mutans provide
            insights into chromosomal shuffling and species-specific content
  JOURNAL   BMC Genomics 10, 358 (2009)
   PUBMED   19656368
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2013587)
  AUTHORS   Nakagawa,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2008) Contact:Ichiro Nakagawa Tokyo Medical and
            Dental University, Graduate School of Medical and Dental Science,
            Section of Bacterial Pathogenesis; 1-5-45 Yushima, Bunkyo-ku, Tokyo
            113-8510, Japan
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 00:52:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,974
            CDSs (total)                      :: 1,890
            Genes (coding)                    :: 1,830
            CDSs (with protein)               :: 1,830
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 34 of 60
            Pseudo Genes (incomplete)         :: 21 of 60
            Pseudo Genes (internal stop)      :: 25 of 60
            Pseudo Genes (multiple problems)  :: 16 of 60
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:57:33
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 617657
            Orig. end                         :: 640156
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010655.1.
            The complete genome sequence of S. mutans NN2025 was performed by
            Dr. M. Hattori and Dr. A. Yamashita, Department of Computational
            Biology, Graduate School of Frontier Sciences, The University of
            Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan This work
            was done in collaboration with Ichiro Nakagawa, Fumito Maruyama
            (Tokyo Univiersity), Mitsuhiro Kobata (Osaka University), Ken
            Kurokawa (Nara Institute of Science and Technology), Keishin
            Nishida , Atsuo Sakurai (Tokyo University), Kazuhiko Nakano, Ryota
            Nomura, Shigetada Kawabata, Takashi Ooshima (Osaka University),
            Kenta Nakai (Tokyo University), Shigeyuki Hamada (Nihon
            University), and supported by KAKENHI (Grant-in-Aid for Scientific
            Research) on Priority Areas Applied Genomics from the Ministry of
            Education, Culture, Sports, Science and Technology of Japan. This
            clone was isolated from a Japanese patient with dental caries in
            Osaka University.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22499
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RaS-RiPP"
                     /product="RRE-containing"
                     /region_number="4"
                     /rules="(PF04055 and TIGR01716)"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..22499
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="interleaved"
                     /product="RaS-RiPP"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22179
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12179](+)"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12179
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     misc_feature    64..73
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.78"
                     /tool="antismash"
     gene            153..956
                     /locus_tag="SMUNN2025_RS03155"
                     /old_locus_tag="SmuNN2025_0589"
     CDS             153..956
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804161.1"
                     /locus_tag="SMUNN2025_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0589"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_012997649.1"
                     /transl_table=11
                     /translation="MTETGFRYSILASGSSGNSFYLETPQKRILIDAGLSGKKISQLMA
                     EIDRKVDDVDAILVTHEHKDHIHGVGVLARKYGLDVYANAATWQAMDGMIGKIDVSQKH
                     IFDLGKTITFGDIDIESFGVSHDAAQPQFYRLMKDGKSFVILTDTGYVSDRMADLIENA
                     DGYLIESNHDIEILRSGIYPWSLKQRILSDKGHLSNDDGAETMVRTLGNKTKKIYLGHL
                     SKENNVKELAHMTMKNTLMQADLAVDHDFKIYDTSPDTALPLAKI"
     misc_feature    complement(162..180)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.33"
                     /tool="antismash"
     gene            1063..1758
                     /gene="rnc"
                     /locus_tag="SMUNN2025_RS03160"
                     /old_locus_tag="SmuNN2025_0590"
     CDS             1063..1758
                     /EC_number="3.1.26.3"
                     /GO_function="GO:0004525 - ribonuclease III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rnc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019322985.1"
                     /locus_tag="SMUNN2025_RS03160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0590"
                     /product="ribonuclease III"
                     /protein_id="WP_002266141.1"
                     /transl_table=11
                     /translation="MKTLEKKLAEDFKIVFSDKELLETAFTHTSYANEHRLLNISHNER
                     LEFLGDAVLQLTISRYLFDKYPQKAEGDLSKMRSMIVREESLAGFSRNCHFDRYIKLGK
                     GEEKSGGRQRDTILGDLFEAFLGALLLDAGLKAVEAFLNQVVIPKVENNNYERVTDYKT
                     ALQELLQVDGDVLIDYEVLKESGPAHAKCFEVAVSMNHEKLSSGTGKSKKLAEQEAAKN
                     ALEKLQRGS"
     gene            1758..5294
                     /gene="smc"
                     /locus_tag="SMUNN2025_RS03165"
                     /old_locus_tag="SmuNN2025_0591"
     CDS             1758..5294
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="smc"
                     /gene_functions="other (smcogs) SMCOG1218: Exonuclease"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002266942.1"
                     /locus_tag="SMUNN2025_RS03165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0591"
                     /product="chromosome segregation protein SMC"
                     /protein_id="WP_012997650.1"
                     /transl_table=11
                     /translation="MFLKEIEMQGFKSFADKTKVEFDRGVTAVVGPNGSGKSNITESLR
                     WALGESSAKSLRGGKMPDVIFAGTEKRKPLNYAQVTVILDNSDAFIKDAQEEIRIERHI
                     YRNGDSDYLIDGKKVRLRDIHDLFMDTGLGRDSFSIISQGRVEEIFNSKPEERRSIFEE
                     AAGVLKYKTRKKETQSKLTQTQDNLDRLDDIIYELETQIKPLERQAKTAKEFLVLETER
                     KEKQLDLLVYQILHHKEALVKNQAELEKVKQNLAAYYQERDLLETKNQTLKEKRHQLSR
                     QMDQKQADLLEMTRLISDYERQIERIHLEVSQKTEKKQSTQKSLEQLSEQKASLKTELA
                     QKEVDLEQLEEDLKQKNQEIKNVETELSRFATDPDHIIESLREDFVRLMQKEADTSNQL
                     AVLKAEMDSRKQESESKTAEIRQLQADLEKAKDREQRESANFETAKTKVQELLKDYQKT
                     AQLVQNLEAAYAEQQEAMFQLLDDVKDKKARQSSLKSILKSHSNFYAGVRSVLQQADKI
                     KGIVGAVSEHLTFDKKYQTALEIALGASSQNIIVEDEAAAKRSIDFLKKNRQGRATFLP
                     LTTIKPRRLSESNQSLLASSQGFLGLARDLVSFEPRLQTIFGNLLGVTAIFDTVGHANQ
                     AARQLRYQVRLVTLDGTEIRPGGSFSGGTSRQNNTTFIKPELDHLTQELALLEEKQVEQ
                     ERTVEKTKQDLEVKKADLLELREKGNQARLAEQKAEMEYQQSESHLQELVLLYTQLKQT
                     NQADLNRDLEKDQALLQEKLYKIADDKEKLNQEIAQIKEDKDSIQQKTAALSQRLSSLR
                     LSERDLANTQKFERTNLKRLAEELAELEQNEAGMMQLLDSQEEDLDEKRLPSLKQQLAN
                     AQARKTESDQELVRYRFELEDCEAQLEEVETNLLKTNQKNEEFIRQQTQLEAKRDHVSN
                     QLRRFANNLAEDYQLSLDDAKQEAGPIENLEAAQAHLSQLEKQIKGLGPVNLDAIGQYD
                     EVSERLHFLNSQKDDLVHAKELLLNTIHDMDDEVKARFKTTFEAIRDSFKTTFTQMFGG
                     GSADLLLTEGDLLMTGVEISVQPPGKKIQSLNLMSGGEKALSALALLFAIIRVKTIPFV
                     ILDEVEAALDEANVKRFGDYLNRFDKSSQFIVVTHRKGTMSAADSIYGVTMQESGVSKI
                     ISVKLKEVEKIS"
     protocluster    2176..22499
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12175:12499](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12176..12499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
     gene            5734..6777
                     /gene="pheS"
                     /locus_tag="SMUNN2025_RS03170"
                     /old_locus_tag="SmuNN2025_0592"
     CDS             5734..6777
                     /EC_number="6.1.1.20"
                     /GO_component="GO:0009328 - phenylalanine-tRNA ligase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pheS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314825.1"
                     /locus_tag="SMUNN2025_RS03170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0592"
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="WP_002270579.1"
                     /transl_table=11
                     /translation="MDLQAQLEELRKSTQATLKEMSGNHSKELQDLRVKVLGKKGSLTE
                     LLKGLKDLPNELRPVVGKQVNEVRDVLTKAFEEQAKIVEAAKIQAQLESETLDVTLPGR
                     QIHLGNRHVLSQISEEIEDIFLGMGFQVVDGYEVEQDYYNFERMNLPKDHPARDMQDTF
                     YISEDILLRTHTSPVQARTLDKHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLV
                     VGKNISMGDLKGTLEMISKKMFGEDRKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVC
                     KKTGWIEILGAGMVHPSVLEMSGVDSEGYSGFAFGLGQERMAMLRYGINDIRGFYQGDS
                     RFTEQFN"
     misc_feature    complement(6844..6856)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            6850..7371
                     /locus_tag="SMUNN2025_RS03175"
                     /old_locus_tag="SmuNN2025_0593"
     CDS             6850..7371
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019317018.1"
                     /locus_tag="SMUNN2025_RS03175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0593"
                     /product="N-acetyltransferase"
                     /protein_id="WP_002270578.1"
                     /transl_table=11
                     /translation="MSQVEIRKVNQDELSLLQKIAIQTFRETFAFDNTAEQLQNFFDEA
                     YTLSALKLELDDKESETYFILMSGKAAGFLKVNWGSSQTEQVLEDAFEIQRVYILKAYQ
                     GLGLGKQLFEFALERAQISGLSWVWLGVWEKNVKAQLLYAKYGFEQFSKHSFFVGNKVD
                     TDWLLKKSLS"
     gene            7385..9790
                     /gene="pheT"
                     /locus_tag="SMUNN2025_RS03180"
                     /old_locus_tag="SmuNN2025_0594"
     CDS             7385..9790
                     /EC_number="6.1.1.20"
                     /GO_component="GO:0009328 - phenylalanine-tRNA ligase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pheT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311998.1"
                     /locus_tag="SMUNN2025_RS03180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0594"
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="WP_012997651.1"
                     /transl_table=11
                     /translation="MLVSYKWLKELVDIDVPSHELAEKMSTTGIEVEGVDVPAEGLSKL
                     VVGHVLSCEDVPETHLHLCQVDTGEEESRQIVCGAPNITAGIKVIVALPGARIADNYKI
                     KKGKIRGMESLGMICSLQELGLPDSIIPKEYSDGIQILPEDAVPGESIFPYLDLDDEII
                     ELSITPNRADALSMRGVAHEVAAIYDKSVHFEDKVLTESDKKAADLIKVAIASDNVLTY
                     KARVVENVTIKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDLDKFEGKD
                     ILARQAKAGEKLVTLDGEARDLIEEDLVITVADKPVALAGVMGGAATEIDASSKNVVLE
                     AAVFDGKSIRKTSSRLNLRSESSSRFEKGVNYADVAKALDFAAAMLTELADGTVLAGQV
                     SAGAVPTDDIQVSTSLDYVNVRLGTDLVFSDIESVFARLGFGLSGNDEKFTVSVPRRRW
                     DISIQADLVEEIARIYGYDKLPTTLPEAAGTVGELTKSQKLRRKIRSLAEGSGLSEIIS
                     YALTTPEKAVAFTPNPSKVTELMWPMTVERSALRQNIVSGMLDTIAYNVARKSNNLALY
                     EIGKVFEQTADPKKDLPKEIDTFAFALTGLVTEKDFQTAATPVDFFYAKGVLEAILAKL
                     EISVQFVATKEMANMHPGRTALIERDGQVIGYLGQVHPQTAKLYDIPETYVAELNLNAL
                     EAALKSDLVFEDITKFPAVSRDIALLLSEKVSHQDILDAIAASGVKRLTKVKLFDVYAG
                     EKLGQGKKSMAYSLTFQNPNDNLTDEEVAKYMGKITKALTEKIGAEVR"
     gene            10001..10858
                     /locus_tag="SMUNN2025_RS03185"
                     /old_locus_tag="SmuNN2025_0595"
     CDS             10001..10858
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804849.1"
                     /locus_tag="SMUNN2025_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0595"
                     /product="Rgg/GadR/MutR family transcriptional regulator"
                     /protein_id="WP_002293027.1"
                     /sec_met_domain="TIGR01716 (E-value: 2.1e-48, bitscore:
                     161.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEYGKIFKKFRESRGLKMKEVAGSNLSTSHLSRFENGESELTIS
                     KLMTALYEINMPIEEFMYAVNDFHQDELNELLKDVRECVNNKDVERLKAVLIKQQENLK
                     EGRIFHHLNVILVKIRLQDLSGETYYSKADLDYLTNYLFKVEYWGFYELLLFTNTIDVF
                     KHETFMVLSREMMRRSDFYKEIPRNRRLISRMALNSFITCIERDKLIDALYFEKQLSIC
                     HFDETEIYERLVFHYAQNLFAYKKYKTTFAIIEMKKSVAAMKLAGSLHIAETYENHLQK
                     ILEG"
     misc_feature    complement(10906..10919)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 26.23"
                     /tool="antismash"
     gene            11064..12179
                     /locus_tag="SMUNN2025_RS03190"
                     /old_locus_tag="SmuNN2025_0596"
     CDS             11064..12179
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265228.1"
                     /locus_tag="SMUNN2025_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0596"
                     /product="radical SAM protein"
                     /protein_id="WP_002270807.1"
                     /sec_met_domain="PF04055 (E-value: 7.3e-22, bitscore: 75.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 6.9e-47, bitscore:
                     157.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.7e-11, bitscore: 40.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.1e-08, bitscore: 31.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.5e-12, bitscore:
                     44.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.2e-10, bitscore: 38.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDYSPYPLLVDVCVTNRCNLSCSYCSAEAGPFASKKGEMSVEKL
                     DSIFRELNLMGVPRVGVTGGEPFIRDDILDILKAFDKYHFAKVLNTNGNLITDSVAKEL
                     SKLHLDRICVTVDGSCSKVHDSQRGKGSFKKAIEGIKNLQRYNLPVSTLFTLGRHNVDD
                     LINTIRLNDMLRIKYMSVMIICPTGRANDGSILADKKHWYPVFLDLTERLSRGEFKVKF
                     KIVPPNESDVFWTHYFPLAFYNRLDLLESVWHQSLNFNSNKKREISCQAGVRACSINHK
                     GDVYGCDLMNGIDELVAGNVKEKSFYEIWHNSSIFHKLRNITFDDISGKCAGCPLPWCG
                     GGCRCSALELDGTLLGSDLACFYDEEESVLV"
     gene            12176..12499
                     /locus_tag="SMUNN2025_RS03195"
                     /old_locus_tag="SmuNN2025_0597"
     CDS             12176..12499
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265227.1"
                     /locus_tag="SMUNN2025_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0597"
                     /product="PqqD family protein"
                     /protein_id="WP_002293026.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.2e-09,
                     bitscore: 34.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 4.1e-39, bitscore:
                     129.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.2e-08, bitscore: 29.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNHFTIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYC
                     ISKNFSLDKIIEVIQEEYDVSYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFR
                     EAL"
     aSDomain        12191..12412
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SMUNN2025_RS03195_Stand_Alone_Lasso_R
                     RE.1"
                     /evalue="1.80E-11"
                     /identifier="RREFam002.1"
                     /label="SMUNN2025_RS03195"
                     /locus_tag="SMUNN2025_RS03195"
                     /protein_end="79"
                     /protein_start="5"
                     /score="34.9"
                     /tool="antismash"
                     /translation="TIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNF
                     SLDKIIEVIQEEYDVSYDDCKKAIVHFLE"
     aSDomain        12191..12490
                     /aSDomain="Streptide_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM enzyme in a
                     streptide-like cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SMUNN2025_RS03195_Streptide_RRE.1"
                     /evalue="6.00E-41"
                     /identifier="RREFam022.1"
                     /label="SMUNN2025_RS03195"
                     /locus_tag="SMUNN2025_RS03195"
                     /protein_end="105"
                     /protein_start="5"
                     /score="129.9"
                     /tool="antismash"
                     /translation="TIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNF
                     SLDKIIEVIQEEYDVSYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFRE"
     gene            12496..13776
                     /locus_tag="SMUNN2025_RS03200"
                     /old_locus_tag="SmuNN2025_0598"
     CDS             12496..13776
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803472.1"
                     /locus_tag="SMUNN2025_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0598"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_002268932.1"
                     /transl_table=11
                     /translation="MSYSKEVNRYVFPLVATNLVQVLIGQISLHFAVNNSNAALSGISV
                     IQNFLFAFGGILGAFSLSFNIRGAKAFYNKEYQRFKNLLKSSLLIDIGIGLSFILFCLG
                     LSRPFLKVFYGFDGQLLELSTTYFKIMSPYILLTLLIFLFSNLLKIEKKTKPIFWIGTL
                     SSVLDVLLNYYLVPLLGIRGAAISSILSLLVIVLGYFIFVKSLVFQALQEASTSKLELI
                     RFGIPLSIQEILENVLFIMAFDAFMGRQGLRILSIYAVVSQLFAIVRTPAFMYAGSIAI
                     FLPEARKKEDEKALIATIFRNSYAVIFIFACLVTVFSNPFAHFLSDEVIDNVLPFTLYT
                     VVVMGATPLYESSKMLLQSNDDEQWVLKITSIVNILSILILLVLQLMGKQTYQSLYGIY
                     GLSLIVLSILFIKRNSEKRVSSRKMTM"
     misc_feature    complement(13950..13965)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            <14091..14261
                     /locus_tag="SMUNN2025_RS10010"
                     /old_locus_tag="SmuNN2025_0599"
                     /pseudo=""
     CDS             <14091..14261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002998015.1"
                     /locus_tag="SMUNN2025_RS10010"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0599"
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /pseudo=""
                     /transl_table=11
                     /translation="KLFDVYAGEKLGQGKKSMAYSLTFQNPNDNLTDEEVAKYMEKITK
                     ALTEKVGAEVR"
     misc_feature    complement(14320..14333)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            14625..14951
                     /locus_tag="SMUNN2025_RS03205"
                     /old_locus_tag="SmuNN2025_0600"
     CDS             14625..14951
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803471.1"
                     /locus_tag="SMUNN2025_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0600"
                     /product="hypothetical protein"
                     /protein_id="WP_002283068.1"
                     /transl_table=11
                     /translation="MTHVVSEIFKDGPVDRFGLRGDPVFWNYLAKHFQKVAMPYSERKL
                     EEDIRTIYQDLTGKEFRIGEMALVKDFISKSGGMSSGWLSDDFWLKSAIPLLKKRLAKW
                     NETL"
     gene            15126..15371
                     /locus_tag="SMUNN2025_RS03210"
                     /old_locus_tag="SmuNN2025_0601"
     CDS             15126..15371
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261618.1"
                     /locus_tag="SMUNN2025_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0601"
                     /product="SemiSWEET family transporter"
                     /protein_id="WP_002262921.1"
                     /transl_table=11
                     /translation="MLILGWVATFMSIMMYVSYIPQIMNNLAGNKGDFIQPSVAALNCT
                     LWVIYGLCKEKRDLPLAAANMPGIVFGLIAAITALV"
     gene            16036..17019
                     /locus_tag="SMUNN2025_RS03215"
                     /old_locus_tag="SmuNN2025_0602"
     CDS             16036..17019
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002285930.1"
                     /locus_tag="SMUNN2025_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0602"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_002267326.1"
                     /transl_table=11
                     /translation="MDEFNQVERFLYLYTELYKGNTISKQVYLDKFGVSDASFNKDIRK
                     LKDAARHLNLDFDIKINKKESYYYLDYTSETGGNLSDIEAYTLSKILLESRALSKKKTK
                     NIIKKLINRTVNEDYRTILDKQTENELSFYKQLNYFNDENHDQNYLSNLGKLSQAVEDT
                     LKTEIPIKIEYSSKGETKSALILPFAILFHEYYFYITSYKFENEEWVSRTYRLDRIESI
                     SNADGKEIVKAQAFFHKYPSPSLIRDQVIMMFSGEPYLIRLKIVDKTITEYLKDALPTL
                     QVIDEEEAIYEIRTLGVEGIQLFLRRYGSQVEFVSMTELNTGDNEG"
     gene            17209..19995
                     /locus_tag="SMUNN2025_RS03220"
                     /old_locus_tag="SmuNN2025_0603"
     CDS             17209..19995
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283067.1"
                     /locus_tag="SMUNN2025_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0603"
                     /product="CRISPR-associated helicase/endonuclease Cas3"
                     /protein_id="WP_002283925.1"
                     /transl_table=11
                     /translation="MDKKVLRYNFWAKKREEKGQFLWLPLMQHLEDTKNVAGLLWEHWL
                     GEGQKALIIASLKTGKKDEKTAKQLAQFLAAVHDIGKATPVFQSKKGYANSKDLDLELL
                     EKLERAGFEGISSITLANPEKSPHALAGQYILHYNKVKEDIATIVGGHHGKPVDDRATY
                     KNQRSQESNYYQSGKSGNTIYQKWERAQEEILNWALEVSGFKSVDELPTIKQPAQVILS
                     GLLIMADWIASNEDYFPLISIDEREVENKADRLSGFEKWKRSSLWVSRNTWDFEGLYQA
                     RFDFEPRDVQAVLSKTIADTEQPGIFILEAPMGIGKTEAALVATEQLAEKTDRNGIFFG
                     LPTQATSNGIFPRIEKWLESIKEDLDDNISIQLVHGKAALNADFSELPKGISINIDDFE
                     NGSVIVNEWFSGRKTAVLDDFVVGTVDQFLMLALKQKHLALRHLGFSKKVVVIDEVHAY
                     DAYMNQYLLEALRWMGAYGVPVIILSATLPAERREKLLKSYMFGMGKRFEEKEKEQLSK
                     QLKTEAYPLITYNNGFDICQITEFKKGENKKILLSQLEEEDLLDTVKGLLSDGGVAGII
                     VNTVKRAQKIAKVFADSLGEDMVEIFHSGFIATERVRKEQELLKMIGKDANRPYRKIII
                     GTQVIEQSLDIDFDVMISDLAPMDLLIQRMGRLHRHKIDRPQKHVFPKFYVIGMNDDLK
                     FEEGSSFVYGDYLLARTQYYLPDSINLPEDISILVQKVYDEKLELDYPTELLDKKYHNA
                     KSEHETKIGNKESKARDYKIADPVLRETRSRKENLIGWLENSHPDDSDERAYAQVRDIE
                     DIVEVIALKKVGDGYALFGEGEDLSELITDFNIAKKVAQNTLRLPIALTKSYNVDDTIK
                     ELEMYSRMNLNNWQDSSWLKGALGIIFDENNEFLIGGYKLVYDEKYGVRMEEIENHE"
     gene            19988..21706
                     /locus_tag="SMUNN2025_RS03225"
                     /old_locus_tag="SmuNN2025_0604"
     CDS             19988..21706
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002267328.1"
                     /locus_tag="SMUNN2025_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0604"
                     /product="type I-E CRISPR-associated protein Cse1/CasA"
                     /protein_id="WP_012997655.1"
                     /transl_table=11
                     /translation="MSRFNLLDEPWISVVFDEKGSTKEVSLLDFFQNAHHYKDLAGDTK
                     TQDFAVLRVLLAVLHTVFSRFDANGNAYGYLEIDEKYRQIEEIEEDDLEEYEDDLYETW
                     LTLWQNRQFPDIIEEYLKKWRDRFYLFDEEYPFFQVRKEDIEMVMDLNKDAGKIFGKNI
                     NRLVSESSNKIALFSPKHNYDNNKERLSNSEIVRWLLTYHGYSEIGGRMKKIGKRDYSK
                     GWLYNLGGLFLKGKNLYETLLLNLTLFYFEYDNHLHIQKPCWEFDSAVIIDSYVSGKRI
                     DNLASLYTSWSKEVYIDPHVVQPEFECRVAKIPAISPNDLFLEPMTLWKYEENSFQPQS
                     HYTNQSLWRSFGLITMGGMEKLNHIPGIIDWQRTIKDNIENASINICSVGMVSDKTANN
                     TPIIEVFDTLSINEFVLTDIQKDGWVIRINDEVDRVKKVISHTYAYFVKDVIVIRKHIE
                     EKEIPKLKKSILRGSLFRQDYEKQISNRIEELYFKIDQPFRQWLSNIQPGDDKDSKILE
                     WREILEKIVLKEAKSLLYEGNPRDYIGWSYGEPKTFHNIATAYESFTYWLNKNLK"
     gene            21716..22318
                     /gene="casB"
                     /gene_synonym="cse2"
                     /locus_tag="SMUNN2025_RS03230"
                     /old_locus_tag="SmuNN2025_0605"
     CDS             21716..22318
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="casB"
                     /gene_synonym="cse2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002267329.1"
                     /locus_tag="SMUNN2025_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0605"
                     /product="type I-E CRISPR-associated protein Cse2/CasB"
                     /protein_id="WP_002267329.1"
                     /transl_table=11
                     /translation="MSEQSKPTVSSVTRKILMKLSNQIDTSPGKAVLAKIRHSIGKPIN
                     KATEIWSLLFENLPEEFLGKSGRASYEETVILITVQLYALYQQGLSHSVLVEDVEKYHN
                     IGSSLRQLRKGDDTTAIDRRFNVMITSSTFEELTHHLRHLVKLLKSRSPETKIDFAKLS
                     QNLYWFLRDSQETVRLDWAREYYKQDNKGEKDNDNIQ"
ORIGIN
        1 ggattagcaa tcgccaaaga aattgtcaaa cagcataaag gctttatttg ggccaatagt
       61 gaggaaggcg aagggtcgac ctttaccatc gttttacctt atgaaaacga taatgatgca
      121 attgatgaat gggaagaagg tgaagacgaa tcatgacaga aacaggtttt agatacagca
      181 ttctggcttc tggttcaagt ggcaatagtt tttatttgga aactcctcaa aagagaattt
      241 taattgacgc aggcctctca ggtaagaaaa ttagtcaatt aatggcagaa atagaccgaa
      301 aagtagatga tgttgatgcc attttagtaa cacatgaaca taaagatcat attcacggtg
      361 ttggtgtact agctcggaaa tatggtttgg atgtctatgc gaatgcagca acatggcaag
      421 ctatggatgg catgattggt aaaattgatg tcagccaaaa acatatcttt gatctgggga
      481 aaaccatcac ttttggggat attgatattg aaagttttgg tgtcagccat gatgctgctc
      541 aaccacagtt ttaccgcctg atgaaagacg gcaagagctt tgtcatattg acggatacag
      601 gttatgtcag tgatcgtatg gcagatctga ttgaaaatgc tgatggttat ctgattgagt
      661 ccaatcatga tattgaaatt ttacgctcag gtatctaccc ttggagttta aaacagcgta
      721 ttttatccga taaaggacac ctatcaaatg atgatggtgc agaaacaatg gttcgaactt
      781 tggggaataa aacaaaaaag atttatttgg gacatctcag caaagaaaac aatgtcaaag
      841 aattagccca tatgacgatg aagaatactc tcatgcaggc agatttggct gtagatcatg
      901 attttaagat ttatgatacc tcgccagata ctgctttacc attagcaaaa atctagtgga
      961 cagcttaaaa ggaagaatga aaaacaaaga ttactcggaa atggttgttc tgggtgattt
     1021 ttgctataat agaaaggtct aaggataaaa gaaaggattt atatgaaaac attagaaaaa
     1081 aaactggcag aagactttaa gatcgtcttt tctgacaagg aattattgga aactgccttt
     1141 actcatacta gttatgctaa tgagcatcgc ctcctaaaca tttcacataa cgagcgcttg
     1201 gaatttttag gagacgctgt tctgcagtta acgatttcac gttatctttt tgacaaatac
     1261 cctcaaaaag ctgaaggtga tttatcaaaa atgcgttcga tgattgttcg tgaagaaagt
     1321 ttggcgggtt tttctagaaa ttgtcacttt gaccgctata ttaaattagg taagggtgaa
     1381 gaaaaatctg gcggtcgtca aagagatact attttgggag atttatttga agctttttta
     1441 ggtgctcttt tattggatgc aggtcttaaa gctgttgagg cctttctcaa tcaagttgtg
     1501 attcctaagg ttgaaaataa taattatgaa cgtgtgaccg attataaaac ggcacttcaa
     1561 gaattattgc aagttgacgg ggatgttttg atcgattacg aggtcttaaa agaatcagga
     1621 cccgcccatg caaaatgctt tgaagttgct gtttctatga atcatgaaaa acttagtagc
     1681 gggacaggca aatcaaaaaa attagcagag caagaggctg ctaaaaatgc gcttgaaaaa
     1741 cttcaacgag gttcttaatg tttttaaaag aaattgaaat gcagggattt aaatcttttg
     1801 ctgataagac caaggttgag ttcgacagag gagtgacagc cgttgttgga ccaaatggtt
     1861 caggaaagag taatattacg gagagtttac gctgggcttt gggtgagtca agtgctaaga
     1921 gcctgcgtgg cggcaagatg ccagacgtga tttttgcagg aaccgaaaaa cgcaaaccac
     1981 tcaattacgc tcaagtaacg gttattttag ataatagcga tgcttttatc aaagacgctc
     2041 aagaggagat tcgcattgaa cgccatattt atcgtaatgg ggacagcgat tatcttattg
     2101 atggtaaaaa agtacgcctg cgcgatattc acgatttgtt tatggatact ggtttggggc
     2161 gtgattcctt ttccattatt tctcaaggac gtgtggaaga gatttttaat agtaaaccag
     2221 aagagcgtcg ttcaattttt gaagaagcag ccggtgtctt aaaatacaaa acacgtaaaa
     2281 aagagacgca gtctaagcta acacagactc aggataattt ggatcggctg gatgatatta
     2341 tctatgaact ggagacacag ataaagcctt tagaacgtca ggcaaaaaca gccaaagaat
     2401 ttctggtttt ggaaacagag cgcaaggaga aacagttaga cttgctggtc taccaaattc
     2461 tccatcataa ggaagcctta gtgaaaaatc aagctgagct tgaaaaagtt aaacaaaatt
     2521 tagcagccta ttatcaagaa cgtgatctat tagaaactaa gaatcagact ctaaaagaaa
     2581 aaaggcatca gctttctcgt caaatggatc aaaagcaggc tgatctcctt gaaatgacac
     2641 gtctcattag tgattacgag cgtcagattg aacgcattca tttagaggtc agtcaaaaga
     2701 cagaaaagaa gcaatctact caaaaaagcc tagaacaatt gtcagagcaa aaggcttctc
     2761 ttaaaacaga attagctcaa aaagaagttg acttagaaca attagaagag gatctcaaac
     2821 aaaaaaatca agaaattaaa aatgtcgaaa cggaattgtc acgttttgca acagatcctg
     2881 atcatattat tgaaagttta cgagaagatt ttgttagact catgcaaaaa gaggctgata
     2941 cttctaacca attggctgtt ttaaaagcag aaatggatag tcgaaagcaa gaatccgaaa
     3001 gtaaaacagc agaaattaga cagctgcaag cagacttaga gaaagcaaaa gatcgagaac
     3061 aaagggaatc cgcaaacttt gaaactgcta aaaccaaagt tcaagaattg ctaaaggact
     3121 atcaaaaaac agcacagctt gttcagaatt tagaagctgc ttatgctgag cagcaagagg
     3181 ctatgtttca attgttggat gatgtcaaag acaagaaagc acgccaaagc agtctgaagt
     3241 ccatcttaaa aagccatagt aatttctatg caggtgttag gtctgttctt cagcaggctg
     3301 ataaaattaa aggtattgtt ggcgcggtta gtgaacattt aacttttgat aaaaaatatc
     3361 aaaccgcact tgagattgcc ttaggtgcca gcagtcaaaa tattattgtt gaagatgaag
     3421 cggcggccaa acgatctatt gactttttaa agaagaaccg tcaaggtcga gcaacttttc
     3481 ttcctttaac aaccattaaa ccccgtcgtt tatctgagtc aaatcaaagc ctattagctt
     3541 ccagccaggg ctttctcggt ttagcacgtg atttggtaag ttttgagcct cgtttgcaaa
     3601 caatttttgg caatttactg ggtgtcacag cgatttttga tacggttggt catgccaatc
     3661 aggcagctcg ccagttacgt tatcaagtgc gtcttgtaac attagatgga acagaaatcc
     3721 gtcccggagg atccttttca ggaggtacta gtcgtcaaaa taatacaact tttatcaagc
     3781 cagaactgga tcatttgaca caagaactag cgcttttaga agaaaaacaa gttgagcagg
     3841 aaagaacagt tgaaaagacc aagcaggact tggaagtgaa aaaagcagat cttttagaat
     3901 taagggaaaa aggaaatcaa gcccgattgg ctgagcaaaa ggctgagatg gagtatcaac
     3961 aatcagagtc tcatttacaa gagctggtct tgctttatac ccaattaaaa caaacaaatc
     4021 aggcggatct caatcgagac ttagaaaaag accaagcact tttacaagaa aagctgtata
     4081 aaattgctga tgacaaggaa aagctcaatc aagagattgc tcaaatcaag gaagataagg
     4141 atagtattca gcaaaagaca gctgctttaa gtcaacgact ctcttctttg cgactttctg
     4201 agcgcgattt ggctaataca cagaaatttg aaagaacgaa tttaaaacgt ttggcagaag
     4261 aattagctga attggagcaa aatgaagctg gtatgatgca acttttagat agccaagaag
     4321 aggatttgga tgaaaaacgt ttaccatcgc tcaaacagca attagcaaac gctcaggcta
     4381 gaaaaacaga gagtgaccaa gaacttgtcc gctaccgttt tgaactggaa gactgtgaag
     4441 cacagctaga agaggttgag accaatctcc taaaaactaa tcaaaagaat gaagagttca
     4501 ttcgtcagca aacgcaatta gaagcaaaaa gggatcatgt atccaatcaa ttgcgccgtt
     4561 ttgccaataa cttggctgaa gattatcaac taagcttaga tgatgctaaa caagaggcag
     4621 gaccgattga aaatctagaa gctgctcaag ctcatttaag ccaattggaa aagcaaatta
     4681 agggattggg accggtcaac cttgacgcaa tcggtcagta cgacgaagtg tctgagcgtt
     4741 tgcatttctt aaatagtcaa aaagatgacc ttgttcacgc taaggaactt ctcctgaata
     4801 ctattcatga tatggatgat gaggtcaagg cacgctttaa gacgactttt gaagctattc
     4861 gtgacagttt taagacgacc tttacgcaga tgtttggcgg aggaagtgct gacttgcttt
     4921 tgacagaagg agatcttttg atgaccggtg ttgaaatttc agtgcagccg cccggcaaga
     4981 agattcaatc tctcaatctt atgtctggtg gtgaaaaggc actgtctgct ttggcattgt
     5041 tatttgccat tattcgtgtt aaaaccattc cctttgttat tttggatgag gttgaggctg
     5101 ctcttgacga ggccaatgtc aagcgttttg gtgattatct gaatcgtttt gataagtcca
     5161 gccagtttat tgtggtcact caccgtaaag gcaccatgtc tgctgcagat agtatatatg
     5221 gggttaccat gcaggaatca ggtgtctcta agattatctc tgttaagcta aaagaagtcg
     5281 aaaagatatc ttaaaaaggc ttggaagtgc ttagtttgaa aaactgtaag gacacaatca
     5341 atctttgacg gcaatagtac ttaaagtgac tctcaacaag gaaacaaggc ggtaacgaca
     5401 aaatcatttc tgtaaatcgc aatgggatct cgttccccat agaatctttg attcagccta
     5461 ttgagaaatt ttgtgaaatc tgttaaaatg gtaacaattg aataaaagtc tatgagatta
     5521 gtagctttat ggaaatttga cagggaatgc ggggcgtgac tggaaacccg ctggatgaaa
     5581 gtttagtgaa ttcactcaga aagaaagact taaataatta aggtctagtc atactagata
     5641 aaaacggatg gtaccgcgtg tcaacgctcc gcttaaggag ttttggcacg ttttttgttt
     5701 ttaacaaggt ccttaaatag gaaaggaaat cacatggatt tacaagcaca attagaagag
     5761 ctgagaaaat caactcaagc aacattaaag gaaatgagcg gcaatcacag caaagaatta
     5821 caagatttgc gtgttaaggt tttgggtaag aaaggttcct tgacagaact tttaaaaggt
     5881 ctaaaggact taccaaatga gttgcgtcct gttgttggaa aacaagtcaa tgaagtccgt
     5941 gatgtcttaa caaaggcttt tgaagaacaa gctaaaatcg ttgaagccgc caaaattcaa
     6001 gcgcaattag aatcagaaac attagatgtc actcttccgg gacgccaaat acatctaggc
     6061 aatcgccatg ttctcagtca gataagtgaa gaaattgaag atatattcct aggaatgggt
     6121 tttcaagtgg ttgatggcta tgaagttgaa caagactatt acaatttcga acgcatgaat
     6181 ttgcccaaag atcacccggc acgtgatatg caggatactt tttatatttc tgaagacatt
     6241 ttgcttcgga cacataccag tcctgtgcag gcacgtactt tagataaaca tgatttttct
     6301 aaaggaccgc ttaagatgat ttcacccggg cgcgtttttc gccgcgatac agatgatgcg
     6361 acgcattccc atcaattcca tcaaattgaa ggcttggttg ttggtaaaaa catttctatg
     6421 ggtgacctca aaggaacact ggaaatgatt agtaaaaaaa tgtttggtga agatcgtaag
     6481 attcgtctgc gtccttctta tttcccattt acggagcctt ctgttgaagt cgatgtttcg
     6541 tgtttcaaat gcggcggcaa aggctgtaat gtttgtaaga aaacaggttg gattgaaatt
     6601 cttggtgctg gtatggttca tccaagtgtt cttgagatgt ctggcgttga ctctgaagga
     6661 tattctggtt ttgcctttgg cttaggccaa gaacgtatgg ctatgctgcg ctatggaatc
     6721 aatgatattc gaggtttcta tcaaggtgac agccgtttta cagaacaatt caattaaatc
     6781 tataaggttg tagagctttt tgcaggataa ttaccttggt tcagccatcc acaagttaaa
     6841 ggagtgaaaa tgtcacaggt tgaaattaga aaagtcaatc aagatgagct ttctttgctt
     6901 cagaaaattg ctattcagac ttttcgtgaa acctttgctt ttgataatac agcagagcag
     6961 ctgcaaaact tttttgacga agcttatact ttgtccgctt taaaattaga attagatgat
     7021 aaagaatcag aaacctattt tattttgatg tccggtaaag cagcgggatt tttgaaagtg
     7081 aactggggca gctctcaaac cgagcaggta ctagaagatg catttgaaat tcagcgagtt
     7141 tatattttaa aagcctatca aggtttaggt ttaggaaaac agctttttga atttgcttta
     7201 gaacgtgcgc aaatatcagg cttatcatgg gtttggctgg gcgtttggga aaagaatgtt
     7261 aaggcccagt tattgtatgc taaatatgga tttgaacaat tttctaagca ttcttttttt
     7321 gttggtaaca aagtggatac ggattggttg cttaaaaagt ctttaagtta gggaaaggaa
     7381 atacatgtta gtaagttata aatggttgaa agaattagtt gatattgatg tacctagtca
     7441 cgaattggct gaaaaaatgt caacaacagg tattgaagtt gaaggggtag acgttccagc
     7501 agaaggactg tcaaaattag tcgtcggtca tgtcctttct tgtgaagatg ttccagaaac
     7561 gcatcttcat ctttgtcagg tggatactgg cgaggaagaa tctcgtcaaa tcgtttgtgg
     7621 agcaccaaat attacagctg gcatcaaagt aattgttgct cttccgggag ctcgtattgc
     7681 agataattat aagattaaaa aagggaaaat ccgcggtatg gaatctctgg gtatgatttg
     7741 ctctctgcag gagcttggtt tgccggacag cattattcct aaggagtatt cagatggcat
     7801 tcaaattttg cctgaagatg ctgtgccggg tgaaagtatc ttcccttatt tggacttaga
     7861 tgatgaaatc attgagctgt ctatcacacc taaccgtgca gatgctttat ccatgcgcgg
     7921 tgtggctcat gaagtagcag cgatttatga taaatctgtt cattttgaag ataaagtctt
     7981 gactgaaagt gataagaaag cagctgatct tatcaaggta gctattgctt ctgataatgt
     8041 actgacttat aaagcgcgtg tggttgaaaa tgtaaccatt aaaccaagtc cacagtggct
     8101 gcaaaatctg cttatgaatg ctggcattcg tccgattaat aatgtggttg atgtgaccaa
     8161 ttatgttctt ctttattttg gacagcctat gcatgctttt gatttagata agtttgaagg
     8221 caaggatatt cttgcacgtc aggcaaaagc tggtgagaaa ttagtaacac ttgatggtga
     8281 agcgcgtgat ttgattgaag aggatcttgt cattactgta gcagataaac cagtggcact
     8341 tgcaggtgtt atgggtggtg ctgcaactga aattgatgcc tcttctaaaa atgttgtcct
     8401 tgaagcagcc gtctttgatg gaaagtcaat tcgtaaaaca agcagccgtc ttaatctgcg
     8461 ttccgaaagt tcttcacgtt ttgaaaaagg tgttaattac gctgatgttg ctaaggcact
     8521 tgattttgct gcagcaatgc tgacggaatt ggcagatgga acagttctcg ctggtcaggt
     8581 cagtgcagga gcagttccaa cagatgatat tcaagtatct actagtctgg attatgtcaa
     8641 tgttcgctta ggtacagact tagttttctc agatattgaa agtgtttttg ctcgccttgg
     8701 ttttggtctt tctggcaatg acgaaaaatt cacggtttct gtaccgcgtc gccgttggga
     8761 tattagcatt caggcggatt tggtcgaaga gatcgcccgt atttatggtt atgataaatt
     8821 accgacaaca ctgcctgaag cagcaggaac agttggtgaa ttgaccaagt cacaaaaatt
     8881 acgtcgtaag ataagaagtt tggctgaagg tagtggtctt tcagaaatta tttcctatgc
     8941 cttgaccacg cctgaaaagg cagttgcttt tacgccaaat cctagcaagg tgacagaact
     9001 gatgtggcca atgacagttg agcgttcggc actgcgtcaa aatattgtct ctggaatgct
     9061 agataccatt gcctataatg tagcacgtaa gagcaacaat ctagccctat atgaaattgg
     9121 caaagtattt gagcaaacag cggatcccaa aaaagatttg cctaaggaaa tagatacttt
     9181 tgcctttgct ctgacaggtt tagtaactga aaaagacttt cagacagcag caaccccagt
     9241 tgatttcttc tatgctaaag gtgttctgga agctattctt gctaaacttg aaatctctgt
     9301 tcaatttgtt gcgaccaaag aaatggctaa tatgcatccc ggacgcacag ctttaattga
     9361 acgtgatggt caagttatcg gttatcttgg tcaagttcat ccgcagactg ctaaactgta
     9421 cgatattcca gaaacttatg tagcagaatt gaatcttaat gcactggaag cagctcttaa
     9481 atcggattta gtctttgaag atatcactaa attcccagct gtttcgcgcg atattgccct
     9541 gcttctttca gaaaaagtga gtcaccaaga tattttggat gctattgcag ccagcggtgt
     9601 gaaacgcctt accaaagtaa aactctttga cgtttatgct ggtgaaaaat tgggacaagg
     9661 taagaaatca atggcctaca gcctgacttt ccaaaatcct aatgataatc tcacagatga
     9721 agaagttgcc aaatacatgg gaaaaatcac caaagcccta accgaaaaaa ttggtgcaga
     9781 agtgagataa cgaaaaaatc tacctttgaa ggtagatttt tttggtatgt aagctagtga
     9841 gcctacccac cgccgataat gataattgtt tctaatacca ctatcaaagt cataaaaatt
     9901 ttatttctca tgtttttctc ctcactcact tttcttatat gttataataa attgcaatta
     9961 actgaatata aatcccatat agacaattga ggtactattg atgactgaat atggaaaaat
    10021 atttaaaaaa tttagagaat cacgcggtct aaaaatgaag gaagtagctg gttcaaattt
    10081 atcaacttca catctttcaa gatttgaaaa tggagaatct gagctgacaa taagtaaact
    10141 tatgacagca ctgtacgaaa taaatatgcc tattgaagaa tttatgtatg ctgtcaatga
    10201 tttccatcag gatgaattaa atgagctcct taaagatgtg agggagtgtg ttaataataa
    10261 agatgttgaa cgattaaaag cggtattgat taagcaacaa gagaatttaa aagaaggtcg
    10321 aatttttcac catttgaatg ttattctagt aaaaataagg ttgcaagatt tatccggtga
    10381 aacttattat agtaaagcag acctagatta cttaacaaat tacttattta aagttgaata
    10441 ctggggtttc tatgagctgt tactttttac gaatactatt gatgttttta aacatgaaac
    10501 ttttatggtt ctctctagag agatgatgag acggtcagat ttttataaag aaatacctcg
    10561 aaatcgacgt cttatttcac gtatggctct gaattctttt ataacttgca ttgaaagaga
    10621 taaactgatt gatgcactgt attttgaaaa acaattaagc atctgtcatt ttgatgaaac
    10681 agaaatttat gaacgcttgg tctttcatta tgctcaaaat ttatttgcct ataaaaaata
    10741 taagacgaca tttgctatta ttgaaatgaa gaaatcagta gcagcaatga aattggcagg
    10801 gagtttgcat attgctgaaa cctatgaaaa ccatcttcaa aaaattttag aaggataata
    10861 tgaaattgtg tatatgggat aaaaatctct ctttttggat ttgatttata ataattctat
    10921 caaatcaagg aggtaaatac tatgttgact aaaaaagagt ttagtgttcc taaaacaact
    10981 aaggtaaact gttggggtaa gcactagtaa aacaaggtct gtaggtcatt gcatggctta
    11041 cagatttttt aggaggtatt ttaatgagag attattcacc atatccgtta ttggttgatg
    11101 tttgtgtaac aaatcgttgt aatttaagtt gttcatattg ttcagcagaa gcaggccctt
    11161 ttgccagtaa aaaaggagag atgtctgttg agaagctgga ttctattttc cgtgaattaa
    11221 atttaatggg agttccgcga gtaggtgtta ctggaggtga accgtttatt agagatgata
    11281 tattagacat cttaaaggct tttgataaat atcattttgc taaagtttta aatactaatg
    11341 gtaacctcat tacagattct gtagctaagg aattatctaa actgcatttg gatagaattt
    11401 gtgtgactgt ggatggaagt tgctctaaag ttcatgatag ccaaagaggt aaaggaagct
    11461 ttaaaaaggc aatagagggt attaaaaatt tacaaaggta taatcttcct gtttctacac
    11521 tttttacatt aggaaggcac aatgtagatg atttgattaa cactattagg ttaaacgata
    11581 tgcttagaat taaatatatg tctgtaatga ttatttgccc aacaggtaga gctaatgatg
    11641 gaagcattct agcagataag aaacattggt atcctgtatt tttagattta acagagagat
    11701 tgtctcgtgg agaatttaaa gtgaagttta aaatagttcc tccaaatgaa agtgatgtct
    11761 tttggacaca ttatttccca ctagcttttt acaaccgatt agatttactt gaaagtgtat
    11821 ggcatcaaag cctgaacttt aatagtaaca agaaaagaga aatatcttgc caagctggag
    11881 taagagcttg ttctatcaac cataaaggtg atgtttatgg ttgtgatttg atgaacggca
    11941 ttgatgaact tgtagcaggt aatgtaaaag aaaaatcttt ttatgaaatt tggcataatt
    12001 cttctatatt tcataaattg agaaatatta catttgacga tatttcgggg aaatgtgctg
    12061 gttgcccctt accttggtgt ggtggtggat gtagatgcag tgcactggag ttagatggaa
    12121 ctttgcttgg atctgattta gcatgttttt atgatgaaga ggaaagcgta ttggtatgaa
    12181 aaatcatttt acaataaaag ggaagagaga ttttgttgtt gataaaattg acgatgagtt
    12241 tataggatat gatagattag atctagagta ttattctttt gatgatatag gtgctgaaat
    12301 tttatattgt atttctaaaa acttttcttt ggacaaaatc attgaggtca ttcaagaaga
    12361 gtatgatgtg tcttatgacg attgtaagaa agctattgtc cattttttag aggagacacc
    12421 tatattacat attatttatg caaatcttat taaatcagac atttatttat acctaaaacc
    12481 atttcgggag gcattatgag ttattctaaa gaggtgaacc gttatgtttt tcctctcgtt
    12541 gccacaaacc ttgttcaagt tttgattggt caaatttctc ttcattttgc tgtcaataat
    12601 tctaatgctg ccttgtctgg catttctgtt atccagaatt ttctttttgc atttggaggt
    12661 attcttggag cctttagttt gtcgtttaat attagaggtg ccaaggcttt ttataataaa
    12721 gaataccaac gatttaaaaa tcttttaaaa tcatccctgc taattgatat tggaattgga
    12781 ctgtcattca ttcttttttg tctgggattg agtagacctt ttttgaaagt tttttatggt
    12841 tttgatggtc aattattgga actatcgact acctatttca agatcatgtc tccttatatt
    12901 ttattgacct tattaatctt ccttttttca aatcttttga aaattgagaa gaaaacaaag
    12961 cccatttttt ggattggaac cctaagttcc gtgctagatg tcttgttaaa ctattactta
    13021 gttcctcttt tgggaattcg tggagctgct atttcgtcta ttttatcgct gctagtcatt
    13081 gttttagggt atttcatttt tgtaaaatct cttgtttttc aagcgcttca agaggcttcg
    13141 acaagtaagt tagagcttat ccgttttgga attcctttat ccatacaaga aatactggag
    13201 aatgttttat ttatcatggc tttcgacgct ttcatgggaa gacaagggct acgcattttg
    13261 tccatctatg cggtagtcag tcaattattt gcaattgtga gaacacctgc ctttatgtat
    13321 gcgggttcaa tagcaatctt tttgcctgaa gctaggaaaa aagaagacga aaaagcattg
    13381 attgctacta tttttagaaa tagctacgct gttatattta tatttgcttg tttagtaaca
    13441 gtattttcaa atccttttgc tcattttttg tctgatgaag ttattgataa tgtgctgcct
    13501 tttactttgt acacggttgt ggtcatggga gcaacacctc tatatgaaag ctctaagatg
    13561 cttttgcaaa gcaatgatga cgaacaatgg gttttaaaaa taacaagcat tgtcaatata
    13621 ttaagtatcc ttatcttatt agttctccag ttaatgggca agcaaaccta tcaatctctg
    13681 tatggcattt atggtttgag tttaatagtg cttagtattc ttttcataaa aagaaatagt
    13741 gagaagagag tatcatcacg taaaatgaca atgtaaggct tgtagggagt aatacaagtc
    13801 ttttttagaa ctttaatgaa taaaagtttt ttgacagttt acactagttt cacctaaaaa
    13861 atattatcga tttttcaaac gaaacgtcgc agtaatcttt ggtggctaca ttaggaggtg
    13921 atctaaggcc ttgaaaattc ctttgaagat tgacaaatca gttaatcaat cttcttctgc
    13981 ccacggtggt acctatagtt cttagtgacc ttacggtcgc tttcgataag ctaatgtttt
    14041 aggcaataag taggaaatct atgaatatgg gttcttaata tctcaaagta aaactctttg
    14101 acgtttatgc tggtgaaaaa ttgggacaag gtaagaaatc aatggcctac agcctgactt
    14161 tccaaaatcc taatgataat ctcacagatg aagaagttgc caaatacatg gaaaaaatca
    14221 ccaaagccct aaccgaaaaa gttggtgctg aagtgaggta aaaattgaca gctgataagc
    14281 ttatagccgt ctgtttctta tttttaaaca aataacttag caaggacagt gcccatcaat
    14341 gatgtttgct gttagttcaa tatgaaaaga aaattaattt ctgtaaacgt cgtttgtcaa
    14401 gcctataaaa gacctgcatt tatgaaaaca atttcccatt ttaaagggat ggtagtcatt
    14461 tagtttatcc tttatgactt tgttagcgcg tcttaccgta cgtttttgtg actaactttg
    14521 tcagtttaat tatcaccctt taaccttccc agttgttaaa gctgtctgcg gcttgctgcc
    14581 ttgtcttaca atcaaaccaa aagactagaa taaggagaaa ggttatgaca catgttgtat
    14641 ctgaaatttt taaagatggc ccggtagaca ggtttggttt acgaggggat cctgtttttt
    14701 ggaactattt agcaaagcat tttcaaaagg tagctatgcc atattccgaa agaaaactag
    14761 aagaggatat aagaacgatc tatcaagatt taactggaaa agaatttaga ataggtgaga
    14821 tggctcttgt taaagacttt ataagtaaat ccggcggcat gtcatcagga tggcttagtg
    14881 atgatttttg gcttaaatca gctataccgc ttctgaaaaa acgattggca aaatggaatg
    14941 aaactttata aagactgcaa tttattgatt atgaagaatg ataaagcaag caatggtgtc
    15001 ataaaagaca aacgggatgg cttatcattc ttttgaacac aatttgacat tttcaaagaa
    15061 aagtttaaaa tggaaaacag tttgaagaat tgaggtaatg aagaactttg cggaaagaaa
    15121 aaaatatgtt gatattaggt tgggtagcga cttttatgtc tataatgatg tatgtgtctt
    15181 atatccctca gattatgaat aatttagcag gaaataaggg ggattttatc caaccgtcag
    15241 tagctgctct taactgcaca ctgtgggtaa tctatggtct ttgtaaagaa aagcgagacc
    15301 ttcctttagc tgccgccaat atgccaggca ttgtttttgg cttgattgca gcgattacgg
    15361 cattagttta gctttataaa agcatttatt tcataaaggt tgtgaattga gtctgtgaaa
    15421 tagagatttc tgtggaacgg ctcttttttt ctgtcattta tcaacctttt cctgagatga
    15481 tacctactta atcacaatca aatagacgaa gaaatgtgtc aaagttaatg agggctaaat
    15541 aagaaaagct gttagcgacg gtctgtctag ccaccttgct agctttcttt ctcagtgtta
    15601 ttgattgctc gaacgtgtat cgcaaggttt caagaaaatt cactgacgct ggattttcta
    15661 cgaattttgg ataaaagtgt tctaactttt tattgtgtag tggttttagt ttaacgcagt
    15721 gataaattgg aattttcgcg tcttgttttt taggctcaac cctttaaagt tcggtgttct
    15781 gccgaagctt atctaatcta ttttaaggaa agcaagacga caaaattgaa tcgagctttc
    15841 attacgattg gccgaacttt ttatatgtaa ttttatatat ttacactatt ttgtgaataa
    15901 ttgcgtagca atcatgggag tctgtctcac tttctaaaga tcttactagt tcgtcggcga
    15961 aatgaaatta gaatataggt ttatccttca atttggtata ataagaagaa aataaaaaag
    16021 taagtaggtt aagtaatgga cgagtttaat caagtagaac gatttcttta tctctataca
    16081 gaattatata aaggaaatac aattagtaag caagtttatc tagataagtt tggtgtatct
    16141 gatgctagtt ttaataaaga tattcgaaaa ttaaaagatg ctgccagaca tctaaattta
    16201 gactttgata tcaaaataaa caaaaaagag tcatattatt atttggatta tacatcagaa
    16261 actggtggaa atttaagtga tatagaggct tatacattgt ctaaaattct tttagaaagt
    16321 agggcattaa gtaagaaaaa aacaaaaaat attattaaga aacttattaa tcgtacagta
    16381 aatgaagact atcgtacaat cttagacaaa caaactgaaa atgaattatc attttataag
    16441 caactaaatt attttaatga tgaaaatcat gatcaaaatt atttaagtaa tctaggcaaa
    16501 ctttctcaag ctgttgagga tactttgaag acggaaattc ctataaaaat cgagtattct
    16561 agtaaaggag aaactaaaag tgctttaatt ctgccttttg ctattctttt tcatgagtat
    16621 tatttttata tcacatctta taaatttgaa aatgaggaat gggttagccg tacttatcga
    16681 ttagatcgaa ttgagtcaat aagcaatgct gatgggaaag aaattgttaa agcacaggca
    16741 ttttttcata agtatccatc tccttctctt attcgcgatc aggttattat gatgttctct
    16801 ggggaacctt atttgattcg gctaaaaata gtagataaga ctattacgga atatctaaaa
    16861 gatgctttac ctactttaca agttattgat gaagaagaag ctatctatga aataagaacc
    16921 ttaggtgtag aaggtattca gcttttttta agacgttatg gaagtcaagt agaatttgta
    16981 agtatgacag aacttaatac aggcgataat gagggctaag aactatttta agttcttagc
    17041 ccttttagat taaaatgtaa gagttttaca atataggact ataaaaattg gtaagttagt
    17101 caataaagtg taaatttttc caaatatatt gttatatttc atattttatt atatattgta
    17161 atcacagagt aagaatccga gttaatgttt gtgaaaggaa agttgtttat ggataagaaa
    17221 gtactaaggt ataatttttg ggcgaaaaag cgggaagaaa aaggacaatt tctttggctt
    17281 cctctcatgc agcatttaga ggatacaaaa aatgtagctg gtctactgtg ggaacattgg
    17341 ctgggagaag ggcaaaaggc tctaattatc gcctccttaa agacgggtaa gaaagatgag
    17401 aaaacagcca aacaattagc ccagtttttg gctgccgtcc atgatattgg taaggctact
    17461 ccagttttcc aaagtaagaa aggttatgca aattctaagg atttggatct ggaattgttg
    17521 gaaaaattgg aacgggctgg ttttgaaggg atttcttcga ttacacttgc taatcctgag
    17581 aaatcccctc atgctctagc tggacaatat attctgcatt acaataaagt caaagaagat
    17641 attgccacaa tcgttggagg acatcatggt aagcctgttg atgatagggc tacatataaa
    17701 aatcagcggt cacaggagtc aaattattat cagtcaggaa aatctggaaa taccatttat
    17761 caaaaatggg agcgagcgca agaagagatt ttaaattggg cattagaagt tagcggtttt
    17821 aaatctgtgg acgagcttcc gacaattaaa cagcctgccc aagtcatttt gtctggcctg
    17881 ctcattatgg ctgactggat tgccagcaat gaagattact tccctttgat ttccatagat
    17941 gagcgtgaag tggaaaataa agccgaccga ttgtcgggct ttgaaaaatg gaaacgcagc
    18001 agtttgtggg tatcaagaaa tacctgggat tttgaaggcc tttatcaggc acgattcgat
    18061 tttgaaccta gggatgttca agctgtacta tcaaaaacga tagctgatac agaacaacct
    18121 ggcatcttta ttttagaagc tccaatgggg ataggaaaaa cggaggcagc tctggttgca
    18181 acagagcaac tggctgaaaa aactgatcga aatggtatct ttttcggact gccaactcag
    18241 gcgacttcta atggcatttt tccgaggatt gaaaaatggc tagaaagtat aaaagaggat
    18301 ttggatgaca atatttctat tcagttagtc catgggaaag cagccttgaa cgctgatttt
    18361 tctgagctgc ctaaaggaat cagcatcaat attgatgatt ttgaaaatgg cagtgtaatt
    18421 gttaatgaat ggttttctgg aaggaagact gcagtgctgg atgattttgt tgtggggact
    18481 gtggatcaat tcctgatgct tgcacttaaa caaaaacatt tggccttgag gcatttaggg
    18541 ttcagtaaga aggttgtagt aattgatgaa gtgcatgcct atgatgcata catgaatcag
    18601 tatttactgg aggccctgag atggatgggt gcctatggtg ttcctgttat catcctttca
    18661 gctaccttac cggctgagag aagggaaaaa ctgctaaaaa gttatatgtt tggaatggga
    18721 aaacgttttg aagagaaaga aaaggaacag ctatctaaac agttaaaaac agaagcttat
    18781 ccattgataa cctataataa tggttttgac atttgtcaga taacagagtt taaaaagggt
    18841 gaaaataaaa aaatacttct ttcccagctg gaggaagagg atttattaga caccgtaaaa
    18901 gggctgttgt ctgacggagg cgtggcaggt attattgtca atacagttaa gcgagctcaa
    18961 aaaatagcaa aagtatttgc agatagtctg ggtgaagata tggttgaaat ctttcattcg
    19021 ggttttatag caacagaaag ggttcggaag gaacaagaac ttttgaagat gattggaaaa
    19081 gatgctaaca gaccttatcg taaaatcatt attggaacgc aagtaattga gcagtcgctg
    19141 gatatcgact ttgatgtcat gattagcgat ttggctccta tggatctgtt gattcagcgg
    19201 atggggagat tgcatcgtca taagatagat cgtccacaga agcatgtttt tccaaaattt
    19261 tatgtgatag gaatgaatga tgatttgaaa tttgaggaag gctcttcctt tgtttatggc
    19321 gattatttat tagcaagaac ccagtattat ttgccggatt cgattaatct gccagaagat
    19381 atttcaattt tagttcaaaa agtttatgat gagaaattag agcttgatta tccaactgaa
    19441 cttttggata aaaaatatca taatgcgaaa agtgaacatg agactaaaat cgggaataaa
    19501 gaaagtaaag ctagagacta taaaattgca gatccagttt taagggaaac gagaagccgc
    19561 aaggaaaatc tcataggctg gctagaaaat agtcatcctg atgacagtga tgaaagggct
    19621 tatgctcagg tgcgtgatat tgaagacatt gttgaagtca ttgcattgaa aaaggttggc
    19681 gatggttatg ctttgtttgg cgaaggagaa gatctttctg aattaattac cgatttcaat
    19741 atcgctaaaa aagttgccca aaataccttg agactgccta tagctttaac taaatcctat
    19801 aatgttgacg acacgattaa ggagttggaa atgtacagta ggatgaactt aaataattgg
    19861 caagattcct cttggcttaa gggagctttg ggaattatat ttgatgaaaa taatgaattt
    19921 ctcatcggag gttataaact tgtatatgat gagaaatatg gcgtaagaat ggaggaaatc
    19981 gaaaatcatg agtagattta atttattgga tgaaccttgg atttcagtag ttttcgatga
    20041 gaaaggttca actaaggaag tgtccttgct tgatttcttt caaaatgccc atcattacaa
    20101 ggatttagct ggagatacaa aaactcaaga ttttgccgtt ttgagagtgc ttttagctgt
    20161 cctacacaca gtattttcaa gatttgatgc aaatggcaat gcttatggat atcttgaaat
    20221 tgatgaaaaa tatagacaga tagaagaaat tgaagaagat gaccttgagg agtatgaaga
    20281 tgacctttac gaaacttggc tgactctttg gcaaaacagg caatttccag atattattga
    20341 agaatatttg aaaaaatggc gagacagatt ttaccttttt gatgaagaat atccgttttt
    20401 tcaagtgaga aaagaggata ttgaaatggt tatggatttg aataaggatg ctgggaaaat
    20461 ttttggaaaa aatattaatc gtttagtgtc ggaaagctca aataagatag ctttgttttc
    20521 accaaagcat aattatgaca acaataagga acgtctctct aattcagaaa ttgtaagatg
    20581 gttactgacc tatcatggct acagtgaaat tggaggtcgt atgaaaaaga taggaaaaag
    20641 ggattattca aaaggttggc tttacaattt gggtggctta tttttaaaag gaaaaaatct
    20701 ctatgaaact ttattgctga atctgacttt attttatttt gagtatgaca accatttgca
    20761 tattcaaaag ccttgttggg aatttgatag tgcagttatt attgacagct atgtcagtgg
    20821 aaaaagaatt gataatttag cttctctata tacatcgtgg agtaaagaag tttatattga
    20881 tccacatgtt gttcaacctg aatttgagtg cagagtagct aaaattcctg ctatttctcc
    20941 aaacgatcta tttttggaac caatgacatt atggaagtat gaagagaatt cctttcaacc
    21001 acaatctcat tatactaatc aatctttatg gaggtcattc ggtttaataa caatgggtgg
    21061 tatggagaaa ttaaatcata tacctggtat aatagattgg caaagaacaa taaaagataa
    21121 tattgagaat gctagcatca atatatgttc ggtagggatg gtgtctgata aaacagctaa
    21181 caatactcca ataattgaag tttttgatac tctttccatt aacgaatttg tattgactga
    21241 tatccaaaaa gatggttggg tcatcagaat taatgatgaa gtggacagag taaaaaaggt
    21301 tatttcacat acttatgctt attttgttaa ggatgtgata gttattagaa aacatattga
    21361 ggaaaaggaa attccaaaat taaaaaaatc gatacttcgt ggctctttat ttcgacagga
    21421 ttatgaaaaa caaataagta atagaatcga agaactgtat ttcaaaattg atcagccttt
    21481 tagacaatgg ttgtccaata ttcaaccggg tgacgacaag gattctaaaa tcttggagtg
    21541 gagagaaatc ctggaaaaaa tcgttttaaa agaagctaaa tcacttttat atgaaggtaa
    21601 tccgagagat tacattggat ggagttacgg ggaaccaaaa actttccaca atatagccac
    21661 tgcttacgaa agtttcactt attggctaaa taaaaattta aaataggagg gaaaaatgtc
    21721 ggaacaatct aaaccaaccg tttcttcagt taccagaaag atactgatga aactaagtaa
    21781 tcaaatcgat acttcacctg gtaaagctgt tctagctaaa attcgtcatt ccattggaaa
    21841 accaatcaat aaggctacag aaatatggtc gctgttattt gaaaatttac cagaagaatt
    21901 tttaggaaaa tctggtagag caagttatga agaaaccgta attttaatca ctgttcaact
    21961 gtacgccctt taccagcaag gtctatcaca cagtgtgcta gttgaagatg ttgaaaaata
    22021 ccataatatt ggaagttcac tcaggcagct gcgtaaagga gacgatacga ctgcaataga
    22081 tagacgcttt aatgtcatga taacctcttc aacatttgaa gagttaaccc atcatttaag
    22141 gcatctcgtt aaacttttaa aatcaaggtc ccctgaaacc aagattgatt ttgcaaagtt
    22201 atcccaaaat ctatattggt ttttaaggga ttctcaggaa actgtccgtt tggattgggc
    22261 gagagaatac tacaaacaag ataataaagg agaaaaagac aatgacaata tccaataatc
    22321 aagatagact atttttagat atttacgcta tccaaaccct tcctccatca aacatcaacc
    22381 gtgatgatac tggtagtcct aaaactactc aatacggcgg ggttaggcga gcacgagtta
    22441 gctcgcaatc ttggaaaaaa gccatgagag attattttta tgaacacgct gaagaagaa
//
