LOCUS       NC_013928              22787 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptococcus mutans NN2025, complete sequence.
ACCESSION   NC_013928
VERSION     NC_013928.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans NN2025
  ORGANISM  Streptococcus mutans NN2025
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Maruyama,F., Kobata,M., Kurokawa,K., Nishida,K., Sakurai,A.,
            Nakano,K., Nomura,R., Kawabata,S., Ooshima,T., Nakai,K., Hattori,M.,
            Hamada,S. and Nakagawa,I.
  TITLE     Comparative genomic analyses of Streptococcus mutans provide
            insights into chromosomal shuffling and species-specific content
  JOURNAL   BMC Genomics 10, 358 (2009)
   PUBMED   19656368
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2013587)
  AUTHORS   Nakagawa,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAR-2008) Contact:Ichiro Nakagawa Tokyo Medical and
            Dental University, Graduate School of Medical and Dental Science,
            Section of Bacterial Pathogenesis; 1-5-45 Yushima, Bunkyo-ku, Tokyo
            113-8510, Japan
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 00:52:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,974
            CDSs (total)                      :: 1,890
            Genes (coding)                    :: 1,830
            CDSs (with protein)               :: 1,830
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 34 of 60
            Pseudo Genes (incomplete)         :: 21 of 60
            Pseudo Genes (internal stop)      :: 25 of 60
            Pseudo Genes (multiple problems)  :: 16 of 60
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:57:33
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 340880
            Orig. end                         :: 363667
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010655.1.
            The complete genome sequence of S. mutans NN2025 was performed by
            Dr. M. Hattori and Dr. A. Yamashita, Department of Computational
            Biology, Graduate School of Frontier Sciences, The University of
            Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan This work
            was done in collaboration with Ichiro Nakagawa, Fumito Maruyama
            (Tokyo Univiersity), Mitsuhiro Kobata (Osaka University), Ken
            Kurokawa (Nara Institute of Science and Technology), Keishin
            Nishida , Atsuo Sakurai (Tokyo University), Kazuhiko Nakano, Ryota
            Nomura, Shigetada Kawabata, Takashi Ooshima (Osaka University),
            Kenta Nakai (Tokyo University), Shigeyuki Hamada (Nihon
            University), and supported by KAKENHI (Grant-in-Aid for Scientific
            Research) on Priority Areas Applied Genomics from the Ministry of
            Education, Culture, Sports, Science and Technology of Japan. This
            clone was isolated from a Japanese patient with dental caries in
            Osaka University.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22787
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22787
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22787
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12787](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12787
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            81..383
                     /gene="gatC"
                     /locus_tag="SMUNN2025_RS01660"
                     /old_locus_tag="SmuNN2025_0313"
     CDS             81..383
                     /GO_component="GO:0030956 - glutamyl-tRNA(Gln)
                     amidotransferase complex [Evidence IEA]"
                     /GO_function="GO:0050567 - glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gatC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003080373.1"
                     /locus_tag="SMUNN2025_RS01660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0313"
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="WP_002263475.1"
                     /transl_table=11
                     /translation="MKISEEEVRHVANLSKLKFSDDETTEFATTLTKIVDMVELLNEVD
                     TQGVPFTSNVADNINYMREDVSVAGWDREQLFKNVPEHEDGLIKVPAIIDEGGDA"
     gene            383..1849
                     /gene="gatA"
                     /locus_tag="SMUNN2025_RS01665"
                     /old_locus_tag="SmuNN2025_0314"
     CDS             383..1849
                     /GO_component="GO:0030956 - glutamyl-tRNA(Gln)
                     amidotransferase complex [Evidence IEA]"
                     /GO_function="GO:0050567 - glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gatA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677783.1"
                     /locus_tag="SMUNN2025_RS01665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0314"
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="WP_002271770.1"
                     /transl_table=11
                     /translation="MTFNHKSIDELHDLLVNKEVSALELTKATLEDIKEREETVGSFIT
                     VTQEEALAQAAAIDEKGIDVDNVMSGIPLAVKDNISTKNILTTAASKMLYNYKPIFDAT
                     SVEKLYGRDMIIVGKTNMDEFAMGGSTENSYFKLTKNAWNQEKVAGGSSGGSATAVASG
                     QVRLSLGSDTGGSIRQPAAFNGVVGIKPTYGRVSRFGLIAFGSSLDQIGPFSQTVKENA
                     QLLNVISGNDKKDSTSSQVKVPDFTQFIGKDIKGMKIALPKEYIGQGIDEKVKETILTA
                     AKHLESLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRTDDYENLDDV
                     YVNTRSEGFGEEVKRRIMLGTFSLSSGYYDAYFKKAGQVRTLIMEDFKKVFANYDLILG
                     PTAPTVAYDLDSQHQDPVAMYLADLLTIPVNLAGLPGISIPAGFVEGLPVGMQLIGKPF
                     AEQTIYQAAAAFEASTDYHKQQPVIFGGGN"
     gene            1849..3288
                     /gene="gatB"
                     /locus_tag="SMUNN2025_RS01670"
                     /old_locus_tag="SmuNN2025_0315"
     CDS             1849..3288
                     /EC_number="6.3.5.-"
                     /GO_function="GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /codon_start=1
                     /gene="gatB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314904.1"
                     /locus_tag="SMUNN2025_RS01670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0315"
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="WP_002281592.1"
                     /transl_table=11
                     /translation="MNFETIIGLEVHVELKTNSKIFSPAPAHFGEDPNANTNIVDWSFP
                     GVLPVMNKGVIDYGIKAALALNMDIHQRMHFDRKNYFYPDNPKAYQISQFDEPIGYNGW
                     IEIELEDGSTKKIRIERAHLEEDAGKNTHGVDGYSYVDLNRQGVPLIEIVSEADMRSPE
                     EAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISIRPYGQEAFGVKTELKNLNSFNFV
                     RRGLAYEEKRQAEVLRSGGQIQQETRRYDEATGETLLMRVKEGSADYRYFPEPDLPIFE
                     IEDEWIEKVRAELPAFPKERRTKYVNNLGLSAYDAAQLTNSKAISDFFEAALAQGVDAK
                     TASNWLQGDIAQYLNAENQTIDQIGLTPENLTEMLQLVADGTISSKIAKKVFVHLAKNG
                     GSAKEYVKSAGLIQISDPAQLLPIIQEVFANNEKALNDYKGGNKNAAKSLVGQIMKATR
                     GQANPQVAQKLLNEELAKLTD"
     gene            <3833..4786
                     /locus_tag="SMUNN2025_RS10605"
                     /pseudo=""
     CDS             <3833..4786
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001901474.1"
                     /locus_tag="SMUNN2025_RS10605"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="reverse transcriptase domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VQIISPFCKPRFSETSYGFRPNRSCEKVIVKLLEYLNDGYEWIVD
                     IDLEKFFDRVPQDRLMSLVHHIIQDGDTESFIRSYLYSGVVINGQRHKTLVGTPQRGNL
                     SPLLSNIMINELDKELENRDLHFV"
     gene            4891..5589
                     /locus_tag="SMUNN2025_RS01680"
                     /old_locus_tag="SmuNN2025_0319"
     CDS             4891..5589
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002294154.1"
                     /locus_tag="SMUNN2025_RS01680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0319"
                     /product="response regulator"
                     /protein_id="WP_002263491.1"
                     /transl_table=11
                     /translation="MSFESQLLKKHILIVDDDTSLNQSIKEVLMSRGFNNISSAYSIDE
                     GIDIFSVSKIDLIILDVMLPDGEGYLLAKYIRKSSDVPILFLTAKNSPDDEIKGLDSGG
                     DDFVTKPFLPKTLSYRIIALLRRSYKGESELIELTFCTIDLNNASVLKGNEHLSLTPTE
                     IQILRKLYVNKNHIVSTEAICDAVWGLENFGYEKSLMVHIRNIREKIEKNSSKPVHLIT
                     VKGLGYKLVI"
     gene            5607..6986
                     /locus_tag="SMUNN2025_RS01685"
                     /old_locus_tag="SmuNN2025_0320"
     CDS             5607..6986
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002266300.1"
                     /locus_tag="SMUNN2025_RS01685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0320"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_012997586.1"
                     /transl_table=11
                     /translation="MNILKRSALRFVFFFILVLLLNIVFVLAAMAYVNSQQYPPDTSET
                     IASEITLSDGSYHVSPKAKRLISQEKLWVMIIDKNTGREIFNINKPQQIGTHFNYADVV
                     RFSRFYLHDYPVFTRIKDDENAIYIVAFPKDSIIRYSYNFLESHRYRFIPILALGIISI
                     NVLLCLFLYIYSVTFLNRNIRPIINAIGKLPGGLNTQVNSVKELDRLALAVNSANQQLR
                     ENEEFKENWISGIAHDIKTPLSVIVSNTSLAIEKTDNENLLKHLNPTLVESHYIQNLLN
                     DLNIFARLTNGNLELKKEIVTIIPFFKEIIIQIVNQDVWEEFQFEFDAESNLSGKKMYV
                     EKALISRVIHNLIYNSVLHNSHGCTIKIELKSYSDDNFKITVQDNGVGTSLEKLKNINK
                     IEEFTFDISGVRRSGMGLKISKQIIDLHNGDMIIKSEQGRYFKTDIILPIAFTSGSDNP
                     L"
     gene            complement(7565..8821)
                     /locus_tag="SMUNN2025_RS01695"
                     /old_locus_tag="SmuNN2025_0321"
     CDS             complement(7565..8821)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002948696.1"
                     /locus_tag="SMUNN2025_RS01695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0321"
                     /product="ISL3-like element ISSmu2 family transposase"
                     /protein_id="WP_012997587.1"
                     /transl_table=11
                     /translation="MRLIKNTTELIGIKDPNIIIFLVFETDTHIESQAKRNYPAPSCPH
                     CQGKMIKYDFQRPSKIPLLEQAGTPTLLRLKKRRFQCKGCKRVMVAETSIVEKNCQISN
                     LVRQKVAQRITEKVSLTDIARRLRVSTSTVYRKLDQFTFKEHYDRLPRVMSWDEVGFKK
                     GELAFVAQNYETNELITILDNRRQTTIRNYFLKYPLKVRQEVRFITMDMSGAYIPMARK
                     LFPNAKIVLDRFHIIQHLGRAFLKTRIAIMNQFDKKSLPYRALKNHWRLFQKDSRKLSL
                     NSFYSKTFRQTLSPHEVVEKTLDFSEELTDYYTLYQLLLFHFQEKRAEEFFELIEENMS
                     KVNHYFQTIFRTFLKHKQYIKNALETDYSNAKLEATNKLIKDIKRLGFGFRNFINFRKR
                     VFITLNIQKKKTLPVLSRC"
     gene            9096..9254
                     /locus_tag="SMUNN2025_RS01700"
                     /old_locus_tag="SmuNN2025_0322"
     CDS             9096..9254
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268660.1"
                     /locus_tag="SMUNN2025_RS01700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0322"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_002268660.1"
                     /sec_met_domain="L_biotic_A (E-value: 4e-28, bitscore:
                     93.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.6e-05, bitscore:
                     21.7, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNTTNEMLELIQEVSLDELDQVIGGMGKGAVGTISHECRYNSWA
                     FLATCCS"
     CDS_motif       9096..9173
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNTTNEMLELIQEVSLDELDQVIGG"
                     /locus_tag="SMUNN2025_RS01700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9174..9254
                     /prepeptide="core"
                     /locus_tag="SMUNN2025_RS01700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2703.1"
                     /monoisotopic_mass="2701.2"
                     /core_sequence="MGKGAVGTISHECRYNSWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNTTNEMLELIQEVSLDELDQVIGG"
                     /leader_location="[9095:9173](+)"
                     /alternative_weights="2721.1"
                     /alternative_weights="2739.1"
     gene            9281..9433
                     /locus_tag="SMUNN2025_RS01705"
                     /old_locus_tag="SmuNN2025_0323"
     CDS             9281..9433
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269377.1"
                     /locus_tag="SMUNN2025_RS01705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0323"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_002269377.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.1e-21, bitscore:
                     73.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.5e-05, bitscore:
                     21.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQSDEMLELIQEVSLDELDQVIGGAGNGVIRTITQGCRMPNNMQ
                     VLFTC"
     CDS_motif       9281..9355
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKQSDEMLELIQEVSLDELDQVIGG"
                     /locus_tag="SMUNN2025_RS01705_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9356..9433
                     /prepeptide="core"
                     /locus_tag="SMUNN2025_RS01705_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2671.1"
                     /monoisotopic_mass="2669.3"
                     /core_sequence="AGNGVIRTITQGCRMPNNMQVLFTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKQSDEMLELIQEVSLDELDQVIGG"
                     /leader_location="[9280:9355](+)"
                     /alternative_weights="2689.2"
     gene            9473..9628
                     /locus_tag="SMUNN2025_RS01710"
                     /old_locus_tag="SmuNN2025_0324"
     CDS             9473..9628
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002296231.1"
                     /locus_tag="SMUNN2025_RS01710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0324"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_002296231.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.5e-27, bitscore:
                     92.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.6e-05, bitscore:
                     21.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQSNEMLELIQEVSLDELDQVIGGMGKGAVGTISHECRYNSWAF
                     LATCCS"
     CDS_motif       9473..9547
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKQSNEMLELIQEVSLDELDQVIGG"
                     /locus_tag="SMUNN2025_RS01710_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9548..9628
                     /prepeptide="core"
                     /locus_tag="SMUNN2025_RS01710_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2703.1"
                     /monoisotopic_mass="2701.2"
                     /core_sequence="MGKGAVGTISHECRYNSWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKQSNEMLELIQEVSLDELDQVIGG"
                     /leader_location="[9472:9547](+)"
                     /alternative_weights="2721.1"
                     /alternative_weights="2739.1"
     gene            9822..9983
                     /locus_tag="SMUNN2025_RS09965"
                     /old_locus_tag="SmuNN2025_0325"
     CDS             9822..9983
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_d"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268661.1"
                     /locus_tag="SMUNN2025_RS09965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0325"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002268661.1"
                     /sec_met_domain="L_biotic_A (E-value: 4e-24, bitscore:
                     81.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="mature_d (E-value: 1.6e-09, bitscore:
                     34.0, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 9.2e-09, bitscore:
                     31.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKGTQLYLEALEALQEIKVEELDTFIGGGGRASNTISSDCRWNS
                     LQAIFSCC"
     CDS_motif       9822..9908
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKGTQLYLEALEALQEIKVEELDTFIGG"
                     /locus_tag="SMUNN2025_RS09965_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9909..9983
                     /prepeptide="core"
                     /locus_tag="SMUNN2025_RS09965_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.70"
                     /molecular_weight="2468.7"
                     /monoisotopic_mass="2467.1"
                     /core_sequence="GGRASNTISSDCRWNSLQAIFSCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKGTQLYLEALEALQEIKVEELDTFIGG"
                     /leader_location="[9821:9908](+)"
                     /alternative_weights="2486.7"
                     /alternative_weights="2504.8"
                     /alternative_weights="2522.8"
     gene            10001..12787
                     /locus_tag="SMUNN2025_RS01715"
                     /old_locus_tag="SmuNN2025_0326"
     CDS             10001..12787
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303301.1"
                     /locus_tag="SMUNN2025_RS01715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0326"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_002283185.1"
                     /sec_met_domain="DUF4135 (E-value: 9e-77, bitscore: 255.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3e-52, bitscore:
                     174.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQKELLYSQFDVFNKQVIERYLPEVLDESDDIIQDIEEQISDYY
                     RSTLIYLINEKRIDGSLIGSSPESRYNYFTNVLCQQGMILDEIEERFPTITQRVVISLK
                     KYLELSKYVKEAFTADFSELLAEGYLDGVASDISSDDVKIKITGDIHNGNGVCIVAYQG
                     KKVVFKKKSSQPNQLLQTLEREVSQYLDKEVYFISPFLDKGEYFWEKFVSSKPLLSEEE
                     AKEFYCRVGYLLACAYMLNISDLHFENLISSHINPILVDVETVFSTSTFDTIANNDATF
                     KIIESSRDSVLFTGLLPVSEADKVFGGDTSGVLGGIMIGEARIVINHNRDDIRVEKQKY
                     KTENQDHLPYFSDSEGVKTYLNAEDYVDFIKSGFSELSEFFMHRKEFLKTLYSEYGHLQ
                     TRLLFRNTRDYSLIRQLLTSPVYCEQSHVLFEKMEDKFSEVDSHELCQSEEKQLLNMDI
                     PYFYAEIASRDVRDDEGIVWQLTRTALSQVIKKLDNLSSAVINEQLDLIEFSIKTPNAL
                     YSTELQDAYRDFENNQQTQDQDVLISGINELTDVILENEKNSQEDGSTNWLTLKVTDYD
                     AFELVPMDDSVYDGLAGMAIALSEVYDLVDDIRQEKIRLCLQRIFTTLSNSYLELQNQS
                     YFVGKLGLFSALSRISPITGQELPDFVLDGDQDYLVDLDVSTADFLSSFTNEVVALRNS
                     DIKIGNLNQALDKLDELKIISEDFISWDKLESNNVSLAHGNLGVEVALLCLAGNLERPE
                     ALQLFRKAKRFDDRQRLENGWVDKRNSDTSANWCHGSTGVLVARLVQLRLDDRYKLLSP
                     SERTALEADLQHASKQIIDLGFDMTNFSLCHGTSGNLLALSYYQSYLPENDAQRLRAIL
                     DKEYRKLHAFGLTKGWMCSFNTKYNVYGLMTGLPGILYSTAKFLKGADSLDVLIPNL"
     gene            12810..14882
                     /locus_tag="SMUNN2025_RS01720"
                     /old_locus_tag="SmuNN2025_0327"
     CDS             12810..14882
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268663.1"
                     /locus_tag="SMUNN2025_RS01720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0327"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_002283184.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7e-38, bitscore:
                     126.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNEEDCLLACYTMLLNDLGHKVPLYEVYDKDTLPADGLS
                     VSYLLSLNDRFGVTINAYRASFDELLKVYRQRKQRMILHWNQEHFVILEKITSKQVTIV
                     DPAIGRVKYSRDEFLSHYSETMILVKRGDYFQPQSYKQIFWKYFRKTLKLKPVSFFLVS
                     LLFIQTGVLLFSVALRQMLADDFKFWVSMSLLAIVLLFQLIGYFIKNIALDRYNTDFDD
                     NYSKALFQKLLKKPLLYFRNHLNGGVSEKINFKSTLRDNVTLKIIPSCVSFISAIVVFA
                     YLMTISIKLTLILMTMIAIYAVISILLYRKQNEHNQAYLQYLIDFNSELQTDLDDIDYI
                     KIMRREGLTFGSWMRSNQQVTTKYSQILKIENLSQIIGTFFNYISLSSIIVIAVYYKVY
                     IKVSLPDLLVYQTSISLLISSIEQVKGAVFEITRLGVYAEKQSDLLKDSKPITVPSSGS
                     AGYLIKAEHLNFSYGAKKVYSDVNLTVNKGEKIAIVGKSGSGKSTLLLLLAGMLRYDGS
                     LEYGVKNFEDYLSVVLQNMTPRKGSILENLEWSYDDLAPVYQAMKDTSADEIINQLPNK
                     IHSKLLKQGKNLSGGQIQKLLITKSLLKENAIIFWDEAFSNLDEQSKNKIYNNVLQNDR
                     YSERTMLIISHHLDIVNYVDYIIYIDAATGDVIKDSHNHLMQSNENYADFITSKI"
     gene            14997..15914
                     /locus_tag="SMUNN2025_RS01725"
                     /old_locus_tag="SmuNN2025_0328"
     CDS             14997..15914
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263495.1"
                     /locus_tag="SMUNN2025_RS01725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0328"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_002278035.1"
                     /transl_table=11
                     /translation="MDNVIELQNLTKVYNGVTTVDLKKITVHQGEIYGFLGPNGAGKTT
                     TMKMILSLIAPTSGNVLVNDSNIKKDVAYLDQIGSMIEEPSYYPNLTGYENLLVFQKML
                     SFDKNNIWPTLELVGLADEKNTKKLVKAYSLGMKQRLALAFALVKRPKILLLDEPTNGL
                     DPAGIHEIRELIVTLAKEKGLTVFISSHILSEIEHIADRVGIINHGRLVYEGAIEAIQS
                     NAWIEIGGDFSTGDITTALNEYGEYGLVRVLDIAANKLTLGDFSNNDLADFVTYLVEKG
                     FRIFRVVRETETLEDIFLNLTTEV"
     gene            15916..16668
                     /locus_tag="SMUNN2025_RS01730"
                     /old_locus_tag="SmuNN2025_0329"
     CDS             15916..16668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019317089.1"
                     /locus_tag="SMUNN2025_RS01730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0329"
                     /product="ABC transporter permease"
                     /protein_id="WP_002278036.1"
                     /transl_table=11
                     /translation="MTKAIQVEWLKSKRTKSLTVSTLIILIGVFWSILGTVMQKSSSGW
                     EMFFDNQDALPMFLPLAISIFVSRIISNEKEGRTFKLQASNAHGILEIFHNKLWFTSLF
                     FFSMAVVYTSIISFYITFIKGESISGLAPVHQIVTFTLGSFVQICLYIVMAMIMEKQSA
                     VLATGFLGAFVGIVFQRLSMKFWSFFIPWLGTSFLAMYHFGYDDKTETAFATLDNQIFL
                     KLIVYGMYAVLCYLAARYIVSHKGGELL"
     gene            16668..17399
                     /locus_tag="SMUNN2025_RS01735"
                     /old_locus_tag="SmuNN2025_0330"
     CDS             16668..17399
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263497.1"
                     /locus_tag="SMUNN2025_RS01735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0330"
                     /product="ABC transporter permease"
                     /protein_id="WP_002278037.1"
                     /transl_table=11
                     /translation="MKYLSSEWLKLRKLQLLLVGLILLSIGSFVGLGTYYANRQVFIHD
                     TQSRVMWGQLTFYHSQVFYPALLAIFVGISLMPEFERMTFEMLKANNVSIGKLLMSKLL
                     TLTFILVPFQFLLVVIWWVGLKLDNISVTSEIGVHVKWVLLSLIGSLSILSLQSFILVK
                     TKSFAKSVGFSAMGVMVGFVLMLVFEPLSHIFPYSQPMIGLRARALADMSFSEFVIFIV
                     VNVFYTLLFYKLTQRTLEKKG"
     misc_feature    complement(17491..17504)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.03"
                     /tool="antismash"
     gene            <17768..17872
                     /locus_tag="SMUNN2025_RS01740"
                     /pseudo=""
     CDS             <17768..17872
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264751.1"
                     /locus_tag="SMUNN2025_RS01740"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="HASMTTTQKTYLHIIRELENQDIDLIMRSLTSLT"
     gene            17967..18875
                     /locus_tag="SMUNN2025_RS01745"
                     /old_locus_tag="SmuNN2025_0331"
     CDS             17967..18875
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002274361.1"
                     /locus_tag="SMUNN2025_RS01745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0331"
                     /product="DMT family transporter"
                     /protein_id="WP_002278038.1"
                     /transl_table=11
                     /translation="MKKSFKGTVLVVLAAIAWGISGVSGQFLMKQGISVYLLTSLRLLI
                     SGLLLIGVIIWQQPQQVKAILEDKKMLVGIFGFSICGLLLNQFSYLQAIHYTNAGTATV
                     LQYMAPVLVLTIICFKNRSLPTIGELAAILLAILGTFVIATHGQLGNLALTPSGLFWGL
                     FSAVTYTLYMFLPIKLIQEWGSLLVIGLGMLLGGLVFSLVSQSWQCNPQFQANNLLAYV
                     GLIIVGSVFAYTSFLKGVSLIGAVKGSLLASIEPVAAVFFSVTLMKEIFYPIDFLGMLL
                     IILAVLIISIRDLLVTNKEKI"
     gene            complement(18907..20076)
                     /locus_tag="SMUNN2025_RS01750"
                     /old_locus_tag="SmuNN2025_0332"
     CDS             complement(18907..20076)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803049.1"
                     /locus_tag="SMUNN2025_RS01750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0332"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_002264749.1"
                     /sec_met_domain="MGT (E-value: 5e-31, bitscore: 105.1,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKKTHYNILMVNLPFSGHTNPTLGLAQILVQLGHNVTYINAPDW
                     QSKIERTGAHFVPYDHYPDSLSERQKKVKSWSAAYQTVLRMGKDYDCLIYEMLFFPGKA
                     LADRLNIPAYRLFSTFSLNEKILTEFGKTGGFYLTSIFRFTFLRHLLSRKLQRTFQLAY
                     DDLAKEISLNTPELNFTYTVREFQIDADTFDENHYQYVGPSINRPVEPPFDFTPFKNPI
                     IYISLGTLLNRSVSFFKKCIKAFENEPYSIIISLGNRIKKEQLGTMPANVHLYSFVPQL
                     QILERASLFLTHGGMNSVNEAIYYGCPMLVIPVGNDQPRVAQQVADLHLGKCLKRHNLN
                     PQEIKQAAHTILKDSSYKNTILHFQKIAQTAGGNTLIAQTIIKDLQTKP"
     gene            complement(20054..20704)
                     /locus_tag="SMUNN2025_RS01755"
                     /old_locus_tag="SmuNN2025_0333"
     CDS             complement(20054..20704)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002313160.1"
                     /locus_tag="SMUNN2025_RS01755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0333"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002278039.1"
                     /transl_table=11
                     /translation="MKQEAKTQLSKKRIAQTAMTLFLQKGYEETTMREIVHKSGRSKGA
                     IYHHFPSKQEILNFQISLEMDNLRQCLDALISNNQLNAQQKFKGILTYFFENPSLTELT
                     RLHWAEKLPFALLETLKNSLTVVAQYIEAIIQQEIKEKRLNCHYSKELSEILVLLFDIW
                     LDPSIVDFDYQTACQRIDFIALLLEKFDLPLLDENDKNKLKNGLKHYDEKNTL"
     gene            21060..21677
                     /locus_tag="SMUNN2025_RS01765"
                     /old_locus_tag="SmuNN2025_0335"
     CDS             21060..21677
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019313720.1"
                     /locus_tag="SMUNN2025_RS01765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0335"
                     /product="DUF4230 domain-containing protein"
                     /protein_id="WP_002268667.1"
                     /transl_table=11
                     /translation="MKMLKEILGCKIYIWFAALIALVGLFFYWYGMNQNNNKSADSSQS
                     YSMVKYIEATNETVFLNVGIEKVDALSNATKVLGITIPYSQKKAIIILNYEAKLGIKRA
                     VSINKTRENNFEIKIPKFEVIGVKLDDKHPYKLYNRSGELLSGSTEEVDTGKAATSLLT
                     NKEQKKYLKQYSDMIKKSAEDHYKVLFKSIYPDVKLTFVYEN"
     gene            21782..22309
                     /locus_tag="SMUNN2025_RS01770"
                     /old_locus_tag="SmuNN2025_0336"
     CDS             21782..22309
                     /GO_function="GO:0008962 - phosphatidylglycerophosphatase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019315482.1"
                     /locus_tag="SMUNN2025_RS01770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmuNN2025_0336"
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="WP_041160311.1"
                     /sec_met_domain="HAD_2 (E-value: 5.9e-12, bitscore: 42.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIENYRPDFVVEAVYDLTPDSLRKHGIKAVLVDLDNTLIAWNHP
                     DGTPQLRDWLDSMTEADMPVVVVSNNSYTRVKRAVKGFHVDFVSRALKPFSRGINIAVN
                     RYGFSKDEVVMVGDQLMTDIRAAHRAGVKSILVKPLVKSDAWNTKFNRARERRIWKKIE
                     DKYGAFVYKREI"
ORIGIN
        1 ttttgtttta attaacatag gtgattagct ttgttaagca taaacaaaat gattagacta
       61 aaaaaaataa ggagaaaaga atgaaaattt ctgaagaaga agttcgccat gtggctaacc
      121 tttctaagtt aaaattctca gatgatgaaa caacagaatt tgcaacaact ttgactaaga
      181 ttgttgatat ggtggaatta ctaaatgaag ttgatacgca aggtgttcct tttacatcaa
      241 atgtcgcaga taatattaat tatatgcgag aagatgtttc tgtagcaggt tgggatcgtg
      301 aacaactctt taaaaatgtt cctgaacacg aagacggtct gattaaagtg ccagctatca
      361 ttgatgaagg aggagacgcc taatgacttt taatcataaa tccattgatg aattgcatga
      421 ccttcttgtt aataaggaag tttcagcgct agaattaacc aaggctactt tagaagatat
      481 caaggaacgt gaagaaacag taggttcttt tatcactgta acacaagaag aagcattagc
      541 acaggctgct gctattgatg aaaagggaat tgatgtagat aatgttatgt cggggattcc
      601 tttggcagtc aaggacaata tctcaaccaa aaatatttta acaactgctg cctcaaaaat
      661 gctttataac tataaaccta tctttgatgc cacttctgtt gaaaagcttt atggcaggga
      721 tatgattatt gtcggtaaaa ccaatatgga tgaatttgcc atgggtggtt ctactgaaaa
      781 ctcctatttc aagttgacta aaaatgcttg gaatcaagag aaagtagctg gtggttcttc
      841 aggcggttct gcaacagcag tcgcttctgg tcaggtacgt ttgtcacttg gttctgatac
      901 aggtggttct attcgtcaac ctgctgcttt taatggtgtc gttggaatca agccaactta
      961 cggtcgtgta tcacgttttg gtttgattgc ttttggttct tcattggatc aaattgggcc
     1021 attctcacaa acggttaaag aaaatgccca attgcttaat gttatttcag gaaatgataa
     1081 gaaagattca acctcttcac aagtaaaagt acctgatttt acgcagttca ttggtaagga
     1141 catcaaggga atgaaaattg cccttcctaa agaatatatt ggtcaaggaa ttgatgaaaa
     1201 ggtcaaggaa acgattctga cagctgctaa gcatctagaa agcttaggtg ctatcgttga
     1261 agaagtcagt ctgccacaca gtaaatacgg tgttgccgtt tactatatta ttgcttcatc
     1321 ggaagcctct tcaaacttgc aacgtttcga tggcattcgc tatggctatc gcaccgacga
     1381 ttatgaaaat ctggatgatg tctatgtcaa cacccgcagt gaaggttttg gcgaagaagt
     1441 aaaacgtcgt attatgctgg gaactttcag tctttcttca ggttattatg atgcctattt
     1501 caaaaaagct ggtcaagtac gaacacttat catggaagat ttcaagaagg tttttgccaa
     1561 ctacgattta attttaggtc caacagcacc aactgttgct tatgatttgg attcgcaaca
     1621 ccaagatcct gttgctatgt atttagctga cttgttaact attccagtaa atttagctgg
     1681 tctgccaggc atctctatac ctgctggttt tgtggaagga ttgcctgttg gtatgcaact
     1741 aattggaaaa ccatttgctg agcaaaccat ctatcaagca gcggcagctt ttgaagcaag
     1801 tacggattat cataaacaac aaccagttat ttttggaggt ggcaactaat gaattttgaa
     1861 actatcattg gattagaagt ccatgttgaa ttaaaaacaa attctaaaat tttttcacct
     1921 gcaccagcgc attttggaga ggatccaaat gctaatacga atatcgttga ctggtcattt
     1981 ccaggtgtct tgcctgttat gaataagggt gttattgatt atggcatcaa ggctgcactt
     2041 gctctcaata tggacattca ccaacgcatg cactttgacc gcaagaatta tttttatcct
     2101 gataatccca aagcctacca aatttcacaa tttgatgaac ctatcggcta caacggttgg
     2161 attgaaattg aattagaaga tggcagcacc aagaaaattc gcattgaacg cgctcacttg
     2221 gaagaagatg ctgggaaaaa tacgcacggt gttgatggtt attcttatgt tgacctcaac
     2281 cgtcaagggg tccctttgat tgaaatcgta tcagaagctg atatgcgttc acctgaggaa
     2341 gcttatgctt atttaacagc ccttaaagaa attatccaat acacaggaat ttcagatgtc
     2401 aaaatggaag aaggctccat gcgggtagat gccaacattt ctatccgtcc ttatggacag
     2461 gaagcatttg gtgtcaagac tgagttgaaa aacttgaact ctttcaattt tgttcgtcgc
     2521 ggtttggcct atgaagaaaa acgtcaggca gaagtccttc gttctggagg tcaaattcag
     2581 caagaaacac gccgttatga tgaagcaaca ggggaaacct tgttaatgcg tgtcaaagaa
     2641 ggttcagcag attatcgcta cttcccagaa ccagatctac caatttttga aattgaagat
     2701 gagtggattg aaaaagttcg agcagaatta ccagcctttc caaaagaacg ccgcactaag
     2761 tatgtcaata atttaggtct atcagcttat gatgctgccc agttaaccaa ctcaaaagcc
     2821 atttcagatt tctttgaagc agctcttgct caaggtgtag atgcgaaaac agcttctaat
     2881 tggttgcaag gagacatcgc tcaatatctc aatgctgaaa accaaaccat tgatcaaatc
     2941 ggtttgacac ctgaaaattt gactgaaatg cttcagttag tagcagatgg aaccatttct
     3001 tctaaaattg cgaagaaggt cttcgttcat ttagctaaaa atggcggttc tgccaaagaa
     3061 tatgtcaaat cagcaggtct tattcaaatc tctgatccag cacagcttct gccaatcatc
     3121 caagaagtct ttgccaataa cgaaaaagct ttgaatgact acaaaggcgg caacaaaaat
     3181 gcagccaaat ctctagttgg tcaaattatg aaagccacaa gaggacaagc caacccacaa
     3241 gtcgcgcaaa aattgcttaa tgaagaattg gcgaaattaa cagattaaaa tgtaattatt
     3301 ttatttttac aaataaagcg agctgctttg aactgcacct caaaagttga acaagaaatt
     3361 atggcaagga ttggatttga tataataaag tggacacgaa gttaagtgaa aacgaggaaa
     3421 aatattatgc caagaaaagt atttgataaa gcattcaaaa tatctgcagt taaactcatt
     3481 ctagaggaag ggtagtctgt aaagatggtt agttcaactt aagaggttca tccaaatagt
     3541 ttatatcgct ggattcaaga atacgaaaaa tatggagaaa gagcgttccc aggacaaggg
     3601 agcgctcttc gtcatgccca atttgaactt aaaaaactcg aaaaagaaaa taagatatta
     3661 caagaggagt tagctctccg tggtagcgtc cgaatcactc aagaactcta ttgatgagga
     3721 ataaaggtca atcgcaaacg tattgctaga ctacttcatg aactttgtct ctatgctaaa
     3781 ggaagccgct ataaatacaa gtactataac cgtcggcgtt cttcattgag acgtccaaat
     3841 tattagtcct ttctgtaaac ctcgtttctc cgaaacgagt tatggattcc gacccaaccg
     3901 gtcatgtgaa aaagtcatcg ttaagctgct agaatacctt aacgatggct atgagtggat
     3961 tgtagacatt gacctagaaa agttcttcga tagggttccc caagacaggt tgatgtctct
     4021 tgttcatcat attatccaag atggcgatac agagtccttc attcgtagct atctctactc
     4081 gggtgtggtc attaatggac aacgacataa aacgttagta ggaactcccc aaagagggaa
     4141 cctatcacca ctcttatcca atattatgat taatgagttg gataaggaat tggaaaatag
     4201 ggatctacac tttgtctgat acgcagatga ttgtgtcatt acggttggga gtgaagcggc
     4261 cgctaagcga gtcatgcact ctgttagtcg ctttattgaa aagcgattgg gattgaaagt
     4321 caacatgatc aagactaaga ttgtgagacc aagaaagctg aaatatttgg gttttgggtg
     4381 ctgaaaattc tctgagggtt gggaaagtcg tccgcatcaa gatagtgtac agagcttcaa
     4441 gagaaaactc aagaaactaa ccactcgaaa atggagcgtt gacctagata gtcacatcga
     4501 aaaactcaac tgggttatcc gaggttggat aaactattcc tccctgacta atatgaaatc
     4561 tgtcatgtcg agtattgatg aaaggttgcg gacatgcatg agagctatta tctggaaaca
     4621 atggaagaag aaatccaagc gactatgggg acttcttaaa ttaggagttc caaggtggat
     4681 agctgataaa ggatctggct ggggagacca ctatcaatta gtggcgccaa agtcagtcct
     4741 aaaacgtgct atatcaaaat cagtcctagc taaacgtgga ctttaaatta aagaaaagca
     4801 gagcaggtat tttagagata aaaacgaaca atttagtatt ggaaaaccag tgttatatgc
     4861 tataatgaaa gtaattttgg aggtgatagt gtgtcttttg aatcacaatt attgaaaaag
     4921 catatcctaa tcgtagatga tgatacatca ttgaaccagt ccatcaaaga ggttttgatg
     4981 agtcgagggt ttaacaatat cagttctgcc tatagtatag atgaagggat tgatattttt
     5041 tcggtatcaa agattgattt gatcatactg gatgtcatgt tgcccgatgg ggaaggttat
     5101 ttattggcca aatacattcg aaaatcgtca gatgtcccta ttttattttt aaccgcaaaa
     5161 aatagtcccg atgatgaaat caaaggactt gattcaggag gagatgattt tgtcaccaaa
     5221 ccatttcttc ccaagaccct gtcttatagg attatagcct tactgaggcg atcctacaaa
     5281 ggtgaatctg aacttatcga acttactttc tgcaccattg atttaaataa tgccagtgtt
     5341 ttaaaaggca atgaacatct atcactgacc ccaacagaaa ttcagattct tcgcaaactt
     5401 tatgtcaata aaaaccacat cgtctccaca gaagcgattt gcgatgcggt gtggggactt
     5461 gaaaactttg gatacgaaaa atcattaatg gtacatatcc gcaatatcag agaaaaaatc
     5521 gagaaaaact cctcaaagcc agtgcatctc attacagtca agggtctcgg gtataagctg
     5581 gtcatttagg gggtaaggta tctaacatga atattttaaa aaggagtgcc ctaagatttg
     5641 tctttttctt tatcttagtt ttacttctca atatcgtctt tgtactagct gctatggcct
     5701 acgtcaatag tcaacaatac ccccctgata cttctgaaac catagcttct gagatcactt
     5761 tatctgatgg cagctatcat gttagtccta aagccaaacg gctgatttca caagaaaagc
     5821 tgtgggtcat gattattgac aaaaacacag gtcgggagat cttcaatatc aataaacccc
     5881 agcagattgg aacgcacttt aactatgcag atgttgttag attttcccga ttttacttac
     5941 atgattaccc tgtctttact cggataaaag atgacgaaaa tgctatttat attgtggctt
     6001 ttccaaaaga cagtattatc cgatatagct acaatttcct agaatcacat aggtatcgtt
     6061 tcattcctat cttggctctt ggtataatct ctatcaatgt cttgttgtgc ttgtttctct
     6121 acatttacag tgtcaccttt ctcaatcgta atattaggcc tattatcaat gccattggga
     6181 agttacctgg tggtttaaat acacaagtta attctgttaa agaattagat cgattggcac
     6241 tggcagtcaa ctctgccaac caacaacttc gagaaaatga agaatttaaa gaaaactgga
     6301 tatcaggtat tgctcatgat attaaaaccc ccctctccgt tatcgtgtct aatacatcat
     6361 tagccattga aaagactgac aacgaaaacc ttcttaagca cctaaatcct actctggttg
     6421 aaagtcacta cattcaaaat ctactaaacg acctcaatat atttgctcga ttgacaaatg
     6481 gtaacttaga gttaaaaaaa gaaatagtta ccatcattcc tttctttaag gaaattataa
     6541 ttcaaattgt caaccaagat gtttgggaag aatttcagtt tgaatttgat gcagaatcca
     6601 acttatcagg taagaaaatg tatgtcgaga aagccctcat ttctcgtgtt attcataatt
     6661 tgatttataa ttctgtcctc cataatagtc atggctgtac gataaaaatt gaacttaaat
     6721 cctattcaga tgataatttt aaaattactg tacaggataa tggtgtagga acatctctag
     6781 aaaaactgaa aaatatcaat aaaatagaag aatttacttt tgacatctct ggcgttagaa
     6841 gaagcggtat gggcttgaaa atatctaaac aaatcattga tttgcataat ggtgatatga
     6901 ttatcaaaag tgaacaaggc aggtatttta aaacggacat tatactacca atagcattta
     6961 cttctggttc agacaatcct ctatgacgaa ttgcaacata catttcactt ataagaatct
     7021 cgaaggctgt tttgtaatct aaacattgcg tggccaatga ttaataacct ctaaagtctg
     7081 tcctagttcc tcatctgtga ttactgctaa gtctgttctc ctaggacttc cgcagtaagt
     7141 cattggcatt ctcgctgcct cctctttatc aagaagaata gggaaaagaa cctcctagtt
     7201 tttctaagac aggagagttt taatttggtt tggattttct cctttagctc tggtcgtgta
     7261 gctcggtttt ttctctttat acttagctag ttggtcatat tatttctatg ctaattcagc
     7321 tgaataagtt tcattctgat aacaattctc ttgaaagtgt tgctctgcgc acaccaatct
     7381 ttttagcgac ttgacaaggc ttcagtcctg gtttcagata tgtttctatt ttttattcgt
     7441 tatggtaaga tgatgatagc tcattgattt ctctcgtgtt ctgttggtgg ggttacttac
     7501 agtttacacg ttttggaact ctatgagttt aggctctttg tcaactgtag tgggtgacga
     7561 aaagctaaca tctagagagg accggaaggg tcttcttttt ttggatgttc agggtgatga
     7621 acacacgctt tctaaagttg ataaagtttc taaaaccaaa tcccaaacgt ttgatgtctt
     7681 taatcaactt gttagtagct tcaagttttg cgtttgaata gtccgtttct agtgcgtttt
     7741 tgatgtattg tttgtgttta agaaaggtcc taaagatagt ttgaaagtaa tgattgacct
     7801 tgctcatatt ttcttctatg agttcgaaaa actcctccgc tctcttctct tgaaagtgaa
     7861 aaagtaaaag ctggtaaaga gtatagtagt cggtaagctc ttctgaaaag tctagtgtct
     7921 tctcaacgac ttcatgtgga cttaaggttt gacggaaggt ctttgaataa aaagagttga
     7981 gagataactt acggctgtcc ttttgaaaga gtcgccagtg atttttcaag gctcgatagg
     8041 gtagcgactt cttatcaaac tggttcataa ttgcaattct tgtctttaaa aaggcacgtc
     8101 caaggtgctg gataatgtga aatctgtcaa gaacgatttt ggcgtttgga aagagtttgc
     8161 gagccattgg aatataagcc ccagacatat ccattgtgat aaatcgaacc tcttgtcgaa
     8221 cttttaatgg atacttcaaa aagtaattac ggatggttgt ttgacgacga ttatcaagga
     8281 tagttatgag ttcgtttgtc tcataattct gagctacaaa agccaactca cctttcttga
     8341 aaccaacttc atcccaggac ataacccttg ggagtctgtc ataatgttcc ttgaaggtaa
     8401 actggtcaag tttacgatag acagtggacg ttgacacacg aagtcttctg gcaatatcag
     8461 ttagtgatac cttctcagtt atgcgttgtg caactttttg tcggacaaga tttgagattt
     8521 ggcagttttt ctcaacgatt gatgtctcag ccaccattac tctcttacac cctttacact
     8581 ggaaacgacg cttcttaaga cgtagtagtg ttggagttcc agcttgctcg agaagaggaa
     8641 ttttagaagg tctttgaaag tcgtatttga tcatctttcc ttggcaatga gggcatgatg
     8701 gtgcaggata attgcgtttt gcttgactct cgatatgagt atcagtttca aaaacaagaa
     8761 aaataatgat atttgggtct ttaattccga ttaattctgt ggtattctta ataagtctca
     8821 taagttcttc ctaatgatgg tttggtcgct tttcattata gttcttatgg gactttttgt
     8881 gtacactcaa aaagctctat aatctctaaa gagtaattgc tcattataga gattatagag
     8941 cctgagtttt tttgttgtac tatattttac attttatctt atgaaagaaa ttaaaaataa
     9001 ttttaggttt tcttaatatt atctttaaga taagcacata caatggaatt gtaacaaagg
     9061 aagatacaac aactacaaga aaggaataca taataatgaa aaatactact aacgaaatgc
     9121 tggaattaat ccaagaagtc agtcttgatg aactcgatca agttattggt ggcatgggta
     9181 aaggtgctgt tggtactatc tctcatgaat gccgttacaa ttcatgggca ttcttagcca
     9241 cttgttgttc ataatttaaa atcgagagaa ggtaactctt atgaaacaat cagatgaaat
     9301 gttggaattg atccaagaag tcagtcttga tgaactcgac caagttatcg gtggtgcagg
     9361 taatggtgtc attcgtacta ttacacaagg atgtcgcatg cctaataata tgcaagttct
     9421 ttttacatgc tgatcataaa attttgtcaa attatagaag gaaggtagtc taatgaaaca
     9481 atcaaacgaa atgctggaat taatccaaga agtcagtctt gatgaactcg atcaagttat
     9541 cggtggtatg ggtaaaggtg ccgttggtac tatctctcat gaatgccgtt acaactcatg
     9601 ggcattctta gccacttgtt gctcataatt taaaataagt agcttgtctt cgttgttaca
     9661 taaaaagagg ggaacctctt tttttattgt gcttttaaga ttcggaatta actttaactt
     9721 tagtttctct taatcttttc tttaagtgac caatttacaa tagatatgta aacaaaatag
     9781 tttatcagtg atactctaga tttattagtg aggtaaaaaa catgaaaaaa ggaacacaac
     9841 tgtatttgga agcacttgaa gcattgcaag aaattaaagt tgaggaatta gataccttta
     9901 tcggtggggg cggtcgtgct tccaacacta tttcctccga ttgtcgttgg aatagtttac
     9961 aggctatttt tagctgttgt tagttacaaa ggagtaagtc atggatcaaa aagaattatt
    10021 gtatagtcag tttgacgttt ttaataaaca agtcattgaa agatatcttc cagaagtatt
    10081 ggacgagagt gatgatatca ttcaagacat tgaagagcaa atctcggact actaccgttc
    10141 aacattaatc tacttaatta atgaaaaacg cattgacggg agcctaattg gcagttctcc
    10201 agaatcacgt tataactact ttaccaatgt tctatgtcag caaggtatga ttcttgacga
    10261 aattgaagaa cgattcccaa caatcaccca gcgtgtcgtc attagtctta agaaatattt
    10321 agaactaagc aaatacgtaa aagaggcatt tacagcagat ttctctgagt tgctagctga
    10381 aggatatctt gacggtgtag cgtcagatat tagtagtgat gatgtcaaaa ttaaaataac
    10441 tggggatatt cataatggca acggtgtttg tattgttgct tatcaaggga aaaaagtggt
    10501 ttttaaaaag aaatcatctc agccaaatca attattgcaa actttggagc gtgaagttag
    10561 tcagtatttg gataaagaag tttattttat ctctccattt ttggataagg gagagtattt
    10621 ttgggaaaag tttgtatcca gtaaaccatt gttatccgaa gaagaagcta aggagtttta
    10681 ctgtagagta gggtatctat tagcctgtgc ttatatgctt aatatttcag atttgcattt
    10741 tgaaaatttg atatcttccc atataaatcc tatattggtt gatgtggaga ctgttttctc
    10801 aactagtacc tttgatacga ttgcaaacaa tgatgctacc tttaagatca tagaaagcag
    10861 tagagattct gtactattta caggcctact tcccgtatct gaagcagaca aagtttttgg
    10921 aggagacacc agtggtgttt taggtggcat tatgattggt gaagcaagga ttgtaatcaa
    10981 tcataatcgc gatgatattc gtgttgaaaa gcaaaagtat aaaacggaaa atcaagacca
    11041 cctcccttac tttagcgata gtgaaggcgt caagacttat ctcaatgcag aggactatgt
    11101 ggactttatt aaatctggat tttcagagct cagtgagttc tttatgcatc gtaaagagtt
    11161 cttaaaaact ctttactcag aatatggtca tcttcaaaca cggcttttat ttagaaatac
    11221 aagagattat agtttaattc gacagttgct gacctctcct gtttattgtg aacaatccca
    11281 cgttttattc gaaaaaatgg aagataagtt ttctgaagtg gatagtcatg aactgtgtca
    11341 atctgaagaa aagcaattgt taaatatgga tattccatat ttttatgctg agattgccag
    11401 tcgtgacgtt agggatgatg aaggcattgt ttggcagttg acaaggacag ctttaagcca
    11461 agtcattaaa aaattggata atctgagttc tgctgttata aacgaacagc tggatctaat
    11521 cgagttttct attaagactc ccaacgctct atatagcaca gaattgcaag atgcctatcg
    11581 agattttgaa aacaatcagc aaactcaaga tcaagacgtt ctgatatctg gtatcaatga
    11641 gttaaccgat gttattttgg agaatgaaaa gaattcccaa gaagatggca gtaccaattg
    11701 gttgacatta aaggttaccg attatgatgc ctttgagtta gtacctatgg atgattctgt
    11761 ctatgatggt ttggcaggaa tggctatagc tttaagtgag gtttatgact tggttgatga
    11821 catcagacag gaaaaaataa ggctttgttt acagcgtatt ttcacaacat tatcaaactc
    11881 ttatctggag ttgcaaaatc aatcctattt tgtagggaaa ttaggccttt tttctgcctt
    11941 aagcagaatt agccccatta ctggacagga gctgcctgac tttgtcttgg atggagatca
    12001 ggattatctc gtagacttgg atgtttcaac ggcagatttt ctatccagtt tcaccaatga
    12061 agtggtagca ttacgaaata gtgatataaa aataggaaat ctcaatcagg cacttgataa
    12121 gcttgatgag ttgaaaatta tctctgagga tttcatcagc tgggataaat tggaatcaaa
    12181 caatgttagc ttagcacatg gcaacttagg tgttgaagta gctctgctct gtcttgcagg
    12241 caatttagag cgtcctgaag ctttgcagtt gttccgtaaa gctaagagat ttgatgatcg
    12301 gcagcgatta gaaaatggct gggtggataa aagaaattca gataccagtg ctaactggtg
    12361 tcatggctca acaggtgtat tagtagccag attagtgcaa ctccgactgg atgatcgcta
    12421 taaactacta tcgccatctg agcgaacagc tctagaagcc gatttgcagc atgcttcaaa
    12481 gcaaatcatt gaccttggtt ttgatatgac aaacttttct ctctgtcatg gaaccagtgg
    12541 caatttgctt gctctgagct attaccaatc ttacttacca gaaaatgatg ctcaaagatt
    12601 aagggctatc ttggacaagg aatatcgcaa actgcatgcc tttggtttaa caaagggatg
    12661 gatgtgcagc tttaatacaa aatataatgt ctatggtttg atgactggac tgccagggat
    12721 tctttattcc acagcaaaat ttttaaaggg agccgattcg cttgacgttt taatcccaaa
    12781 tctttaagag gtagaaaggt ttatatggta tgaagattat tttgcaaaat aatgaagaag
    12841 actgtctttt agcctgttac acaatgttgc ttaatgattt aggtcataaa gttccattat
    12901 atgaagtgta tgataaagat acattgccgg cagacggtct cagtgtctcc tacctcttat
    12961 cgctaaatga caggtttggt gttactatca atgcttatcg tgcctctttt gatgaattgt
    13021 taaaagtcta tagacagcga aaacaaagga tgattctgca ttggaatcaa gaacattttg
    13081 ttattcttga aaaaatcacc tcaaaacaag tgactattgt tgacccagcg attggacgag
    13141 taaagtatag ccgtgatgag tttttaagtc attattctga aacgatgatt cttgtaaaaa
    13201 ggggggatta tttccagcct caatcgtata aacagatttt ttggaagtat tttagaaaga
    13261 ctctaaagct aaagcccgtt tctttttttc tagtgtcact attattcatt cagacaggtg
    13321 tccttttatt ctcagtagcc ttgaggcaaa tgttggcaga tgatttcaaa ttttgggtta
    13381 gcatgtccct tttggcaata gtacttctct ttcaattaat aggttatttt ataaagaata
    13441 tagccttaga ccgatataac acggactttg atgacaatta cagcaaagcc ttatttcaaa
    13501 aattactaaa aaaaccgctt ctatatttta gaaatcattt gaatggcggt gtctctgaaa
    13561 aaataaattt taaatcaaca cttagggata atgtgacctt gaaaattatc ccgtcatgtg
    13621 tcagttttat ctcagccatt gttgtctttg cttatttaat gacgatatca atcaaattaa
    13681 ccctaatatt aatgacgatg attgccatat atgctgttat ttccatccta ctataccgta
    13741 agcagaatga gcataatcag gcgtatttac aatatttaat tgattttaat tctgagttgc
    13801 agacagacct agatgatata gactatatca aaattatgag gagagaaggg cttacttttg
    13861 gttcatggat gcgtagtaat cagcaggtga caacgaagta ttctcagata ctcaagatag
    13921 aaaatctttc acaaattata gggaccttct ttaactatat cagcttgtct tcgatcattg
    13981 tcattgcggt atattacaaa gtctatatca aagtatcgct tccagacttg ttggtttatc
    14041 aaacgagtat ctccttgttg atatcttcaa ttgagcaagt caaaggtgct gtctttgaaa
    14101 tcacacgatt gggagtatat gctgagaaac aaagtgattt actgaaggac agtaaaccta
    14161 ttaccgtgcc aagttcaggg tccgcgggtt atttaatcaa agcagagcat ttgaactttt
    14221 cttatggtgc taagaaagtt tatagcgatg ttaatttaac agttaataaa ggtgaaaaaa
    14281 ttgctattgt agggaaatct gggagcggaa aatctactct cctcttactg ttagcaggta
    14341 tgctacgtta tgatggctct cttgaatatg gtgtcaaaaa ttttgaggat tatttgagtg
    14401 tggtgcttca aaatatgacg cctagaaaag gaagcatttt agagaactta gagtggagct
    14461 atgatgatct tgctcctgtt tatcaggcca tgaaagatac atcagctgat gaaattatta
    14521 atcagctgcc aaataaaatt cactcaaaat tgttgaaaca agggaaaaat ctatcaggcg
    14581 gtcaaatcca gaagctgctt atcacgaaat ccttgttgaa agaaaatgcc attatttttt
    14641 gggatgaagc tttcagtaat ctcgatgaac aaagtaaaaa taaaatctat aataatgtgt
    14701 tgcaaaatga caggtattca gaaagaacaa tgctgattat cagccaccat ttagacatcg
    14761 tcaactatgt tgactacatt atttatatag atgctgcaac aggtgatgtg attaaggata
    14821 gtcataacca tctgatgcaa agcaatgaaa actatgccga ttttatcacg tctaaaattt
    14881 aaggttgctt tcaggttttc ttaattttat ctttaagtcg gctgggtata ataacaacag
    14941 tatcaaaaag gagcagtcct aacgaaatac tgaacgataa ccaaaggagt gaaaacatgg
    15001 acaatgttat tgaactacag aatttaacaa aggtatacaa tggtgtgacg acagtagacc
    15061 ttaaaaagat tactgtgcat cagggggaaa tatatggttt tcttgggcca aatggtgctg
    15121 gtaagacaac aacgatgaag atgattttgt cacttattgc accaacttca ggaaacgttt
    15181 tagtgaatga cagtaatatc aagaaagatg tcgcttactt ggatcaaatt ggttccatga
    15241 ttgaagagcc atcttattat cctaacctga ctggttatga aaatctttta gtatttcaaa
    15301 aaatgcttag ttttgataaa aataatattt ggccaacgct ggaacttgtc ggattagcag
    15361 atgagaaaaa cacgaagaaa cttgttaaag cctattccct aggaatgaag caacgcttag
    15421 ctttagcgtt tgcattggtg aaaaggccaa aaatcttact gctggatgaa ccaactaatg
    15481 gtctggatcc tgcaggtatt catgagattc gggagttgat tgtaacactg gcgaaagaga
    15541 aggggctgac agtatttatt tctagccata tcttgtctga gattgagcat attgcagatc
    15601 gtgtgggcat tattaaccac ggtcgtctcg tctatgaggg agcgattgaa gcgattcagt
    15661 ccaatgcttg gattgagatt ggcggcgatt tttcaacagg cgatatcacg acagctctaa
    15721 atgaatatgg agaatatgga ttagttaggg ttcttgatat agcagccaat aaattaacct
    15781 taggcgattt ttccaataac gacttagcag actttgtcac ctatttggta gaaaaaggct
    15841 ttcgcatttt tagagttgtt cgtgagacag agactcttga agacattttc cttaatttaa
    15901 caacggaggt ttgagatgac aaaagcaatt caagttgaat ggctgaaaag caagcgaaca
    15961 aaatctctga ccgtttctac tcttattatt cttattgggg tattttggtc aattcttgga
    16021 acagtaatgc aaaaatcatc gtctggttgg gaaatgtttt ttgataatca agatgccctt
    16081 cccatgtttc tgccactagc tattagtatt tttgtttcac gtattataag taatgaaaaa
    16141 gaaggcagaa cctttaaatt acaagcaagt aatgcccatg ggatacttga aatattccac
    16201 aataaattat ggtttacaag tttattcttt ttctctatgg cagtggtata tacttcgata
    16261 atttcatttt atattacctt tatcaaagga gaatcaattt ctggccttgc gcccgtccat
    16321 cagatagtga cgtttacctt aggaagcttt gtacaaattt gcctttatat agttatggca
    16381 atgataatgg aaaaacaaag tgccgtgttg gcaactggat ttctcggggc ttttgtgggt
    16441 atagtatttc aacgtctttc aatgaaattc tggtcttttt tcattccttg gttaggaaca
    16501 agtttcttag caatgtatca ctttggttat gatgataaaa cagaaacggc gttcgctact
    16561 ttggataatc aaatattctt aaagctcatt gtatatggca tgtatgctgt actgtgctat
    16621 ctagcagcga gatatattgt ttcgcataaa ggaggagaac tgttataatg aagtatttat
    16681 cttctgaatg gcttaaatta cgtaaactcc agcttttact agtaggtctt atcttgcttt
    16741 caataggaag ttttgttgga ctaggaacct attatgccaa tagacaagtc tttattcatg
    16801 acactcagtc tcgggtcatg tggggacaat taacgtttta tcatagccag gtcttctacc
    16861 ctgctttact tgccatcttt gtggggatta gtttaatgcc agagtttgag agaatgacct
    16921 ttgaaatgtt gaaggctaat aatgtatcaa taggcaagct attgatgagc aaattactta
    16981 ctttaacgtt cattttagtt ccctttcagt ttttgctggt tgtgatttgg tgggttggct
    17041 tgaaacttga taatattagt gttacttcag aaataggggt tcatgtaaaa tgggtattat
    17101 tatcgttgat tgggtcgctt agtattttaa gcctgcagtc cttcattcta gttaaaacca
    17161 aaagttttgc caaatcagtt ggcttttctg ctatgggggt aatggttggt tttgtactca
    17221 tgctggtttt tgaaccgctc agtcatatct ttccttattc acaaccaatg atagggttac
    17281 gtgctagagc cttagcagat atgtcatttt cggagtttgt tatctttata gtggtaaatg
    17341 tcttctatac attgcttttt tacaaactga cacagcggac actggagaaa aaagggtaga
    17401 gaatcaaaga ttagaaaatt cagagtttag ggacaaaagc ggaaatagaa tcggtaactt
    17461 cttggaatct cggttccacc aagaaaatta gcattgaacg tgcccgtttg gaagaggatg
    17521 ctgggaaaac atccacgctg ctgctgatta ttcctatgat tcctatgtgg agctcaactg
    17581 tcaaagcgtg cctttaaccg aaatcgtttc taaagctgaa agacgaataa aactaaggtt
    17641 cataataaat cgtcttacaa ggaaaagtac agcaatcgct attctttctc tgcgaggcgt
    17701 tttttatttc caaaaatgga aaactaacag gccatttcca aataggtgaa aataatcctg
    17761 atggaatcat gctagtatga caactacgca aaaaacgtat ttacatatta ttcgtgaact
    17821 ggaaaatcaa gatattgatt tgattatgcg ttcattaaca agtctaactt aaaataaaaa
    17881 cgctgatgaa gcttaaacca gcagggtgct ggttttttga tagaaaatta tgctaaaata
    17941 aagaaaaatg tattttggga gtaagtatga agaaatcgtt taagggaacg gttcttgttg
    18001 ttctagcagc cattgcttgg ggcatatcag gagtgtcggg ccaattttta atgaagcagg
    18061 gcatttctgt ctatttattg acttccttgc gtttattgat atcagggctg cttttaattg
    18121 gggttatcat ttggcaacag cctcagcagg tcaaagctat tctagaggat aaaaagatgt
    18181 tagtagggat ttttggtttt agcatttgtg gactgcttct gaatcaattt agttatttgc
    18241 aggctattca ttatactaat gctggaacgg caactgtcct acaatatatg gcacctgttt
    18301 tagttttgac aattatttgt tttaagaatc gcagtttgcc aactataggt gaacttgctg
    18361 ccattctttt agctattttg gggacatttg tcatagctac acacggacag ttaggcaatt
    18421 tggctctaac cccatctggt ctcttttggg gactcttttc tgctgtgact tatactctgt
    18481 atatgtttct tcccattaaa ctcattcaag aatggggcag tctcttagtt attggattgg
    18541 gtatgctgct gggaggtctg gtatttagtc ttgtctctca gtcttggcaa tgcaatcctc
    18601 aatttcaggc aaataacctg ttggcttatg ttggtttaat cattgttggc agtgtttttg
    18661 cttacacttc ttttttgaag ggagtcagtc tgattggtgc tgtaaaaggc agccttctgg
    18721 cttctattga accagtagca gcagtctttt tctcagttac tcttatgaaa gaaatttttt
    18781 accccatcga tttcctaggc atgctgttga ttatactagc cgttcttatc atttctatca
    18841 gagacttatt agtaaccaat aaagaaaaaa tctgagacta taactcagat tttttgttct
    18901 gtttgattaa ggtttggttt gtaaatcttt gataatagtt tgagctatta gggtatttcc
    18961 gccagcagtt tgagcaatct tttggaaatg caagatagta tttttgtaag aagaatcttt
    19021 aagaattgta tgggctgctt gtttgatttc ttgaggattt aagttgtgac gtttgaggca
    19081 tttccccaaa tgtaaatcag caacttgctg ggcgactcga ggctgatcat tgccaacagg
    19141 aatcactagc atggggcagc cataatagat agcttcatta acactgttca tgccaccatg
    19201 agtaagaaaa agtgaagctc tttccaagat ttggagttga ggaacgaaag aataaagatg
    19261 aacattggct ggcattgttc ctagttgttc ttttttaatc ctatttccaa gtgaaatgat
    19321 gatagagtag ggctcgtttt caaaagcctt gatacatttt ttaaaaaagg agacagagcg
    19381 attgaggaga gtacctaatg aaatataaat aatcggattt ttaaaaggtg tgaaatcaaa
    19441 aggcggctcg acaggacgat tgatggaagg cccaacgtat tgatagtgat tttcatcaaa
    19501 cgtatcagca tcaatttgaa attcccgtac tgtatacgtg aaattgagtt cgggagtatt
    19561 aagactgatt tccttagcaa gatcatcata agccagctga aaggttcttt gcaattttct
    19621 tgataaaaga tggcgcagaa aagtgaagcg aaaaatactg gtcagataaa agccacctgt
    19681 tttcccaaat tctgtcagaa ttttttcatt taaggaaaaa gttgagaata gccgataagc
    19741 tggaatattc agtctgtccg ctagagcttt tcctggaaag aatagcattt cataaatcaa
    19801 acaatcgtaa tctttaccca tacgtaagac agtctgatag gcagctgacc agcttttaac
    19861 tttcttttgc ctttctgata acgaatctgg ataatggtca taaggaacaa aatgtgcacc
    19921 cgttctttca atcttacttt gccaatcagg ggcattaata taggtgacat tatgacctag
    19981 ctggactaaa atttgagcaa gtcccaaagt cggattggta tggccggaaa aaggaagatt
    20041 aaccattaaa atgttatagt gtgttttttt catcatagtg ttttaatcca tttttaagtt
    20101 tgtttttatc gttttcatct aaaagaggaa ggtcgaattt ttccagtaaa agtgcgataa
    20161 aatcaatcct ttggcaagct gtctgataat caaagtcaac aatagaagga tccagccaaa
    20221 tatcaaacag taaaacaagg atttctgaaa gttctttaga gtaatgacag ttaagccttt
    20281 tttcttttat ttcctgctgg atgatagctt caatgtattg ggcaaccacc gttagagaat
    20341 tttttaacgt ttctaaaagg gcaaaaggga gtttctcagc ccaatgaagt ctggttaatt
    20401 ctgttaatga aggattttca aaaaaataag ttaggatacc cttaaatttt tgttgggcat
    20461 ttaactgatt attgctgatg agagcatcta gacattgcct tagattgtcc atttccagac
    20521 tgatttgaaa atttagaatc tcttgcttac tgggaaaatg atgatagata gcgccttttg
    20581 aacgtccgct cttgtggaca atttcccgca ttgttgtctc ttcataaccc ttttgcaaga
    20641 ataatgtcat cgctgtttgg gcaattctct ttttagataa ttgcgttttt gcttcttgtt
    20701 tcaaagtata gccctttctt tttcataaaa cagaccgaca gtctgttttt ttagattata
    20761 gtaacgcttt agattggaaa tgtcaaactt aataatctaa ggaataaact tttctataat
    20821 ccttgggacg aaatatatat gaaataattt aaatatattg taaaaattct aaaaatatta
    20881 tataatagac gagtgaaata gaaataaaaa agatttggag aataagtatg aaaaagttgt
    20941 ctttaggact tatattggca gtagtagtga ttcttttagc ttttttaaat ccttatttag
    21001 ctgggattat tggtattgct ggtgtttggt ttttaaagga ttaggagaat agaaatagaa
    21061 tgaagatgtt aaaggaaatt ttgggttgta aaatctatat ttggtttgct gcactgatag
    21121 ctttggtggg attgtttttt tattggtatg gtatgaatca aaacaataat aaatctgctg
    21181 atagttctca atcttattca atggtgaaat atattgaagc gacaaatgaa acggttttct
    21241 tgaatgtagg gattgaaaaa gtagatgcac tttctaatgc gactaaagta cttgggataa
    21301 cgattcctta ctcgcaaaag aaagcaatta tcattttgaa ttatgaagca aaactaggga
    21361 ttaaaagggc tgtttcaata aataaaacga gagagaataa ttttgaaatt aaaattccta
    21421 aatttgaagt tattggtgta aaattggatg ataagcatcc atataaactg tacaatagaa
    21481 gtggcgaatt attaagcggc tctacagaag aagtagatac gggtaaagct gccacatcgt
    21541 tgctaactaa taaagaacag aaaaaatatt tgaaacagta ttctgatatg attaaaaagt
    21601 ctgctgaaga tcattataaa gttttattta aatctattta tcctgatgtc aagttgacct
    21661 ttgtttacga aaattaacga tttaagccct tgttatcaag cagataacag ggctttttct
    21721 tcctcgcctt attctttatt ttatgttaaa ataaaaggta atattttatt tggagaagta
    21781 agtgagtatc gaaaattatc gacccgattt cgtggtagaa gccgtttatg atttaacccc
    21841 tgatagcctg cgaaagcacg gtattaaagc cgttcttgtc gatttggaca ataccttaat
    21901 tgcttggaat catcctgatg gcacacccca gttgcgggat tggctggata gtatgactga
    21961 agcagatatg ccggtagtcg tggtatctaa caatagttat acacgtgtca aacgggctgt
    22021 caaaggtttt catgtagatt ttgtcagtcg ggctctgaaa cctttttctc gcggtattaa
    22081 tatagcagtg aatcgctatg gcttttccaa agatgaagtt gttatggttg gcgatcagct
    22141 aatgacggat attcgtgcgg ctcaccgtgc tggtgttaaa agtattttgg ttaaaccttt
    22201 agttaagtca gatgcttgga atactaagtt taaccgtgcg cgtgagcgtc gtatttggaa
    22261 aaaaatagaa gacaaatatg gtgcttttgt ctataaaagg gaaatttaag tggaagaatt
    22321 attttgtatc ggctgtggag cgcaaattca aacgacagcc aaagagcaag ctggctatac
    22381 accaaagtca gccttggaaa aaggacttga aagcgggaaa atatactgcc aacgctgttt
    22441 tagactgcgt cattataacg aaatcacaga tgtgcatatt tcagatgatg attttttaaa
    22501 gcttctccat gaagtggggg acagcagggc tcttgttgtt aatgtgattg atatttttga
    22561 ttttaatggc tccgttatac cgggattgca gcgttttatc tctagcagtg atttgctttt
    22621 agtgggaaat aaagcggaca ttctccccaa atcagtcaaa tctgggaaaa taacacagtg
    22681 gctgatggag cgtgcgcatg aagaagggtt gcggccgctt gatcttatct taaccagtgc
    22741 ccagaataaa tgggcgataa aagaattaat tgctaagatt gaagaac
//
