GCF_000026665.1 - 8 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NC_011900.1 (Streptococcus pneumoniae ATCC 700669)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	RiPP-like	42,411	55,509
Region 2	RiPP-like	108,349	118,636
Region 3	RiPP-like	463,461	477,543
Region 4	terpene-precursor	1,069,690	1,090,565
Region 5	lanthipeptide-class-ii	1,226,969	1,250,220	Low	thermophilin 1277	ribosomal:RiPP:Lanthipeptide
Region 6	T3PKS	1,650,757	1,691,929
Region 7	lanthipeptide-class-ii	1,898,536	1,921,526
Region 8	RiPP-like	1,945,306	1,955,602

NC_011900.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 42,411 - 55,509 nt. (total: 13,099 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

SPN23F_RS00280: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.54	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.51	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.47	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.47	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.47	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.54	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.51	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.47	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.47	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.47	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.09 out of 26.06

Confidence: medium

Additional weak hits (5):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.29 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.48 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NC_011900.1 - Region 2 - RiPP-like

Download region GenBank file

Download region SVG

Location: 108,349 - 118,636 nt. (total: 10,288 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

SPN23F_RS00590: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000500.5	0.40	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001576.3	0.39	ribosomal	divamide A	Prochloron didemni
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000500.5	0.40	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001576.3	0.39	ribosomal	divamide A	Prochloron didemni
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.23 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.88 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.57 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.88 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.79 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NC_011900.1 - Region 3 - RiPP-like

Download region GenBank file

Download region SVG

Location: 463,461 - 477,543 nt. (total: 14,083 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001388.3	0.53	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.52	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.52	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0000624.3	0.51	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001388.3	0.53	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.52	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.52	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0000624.3	0.51	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.71 out of 26.06

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.08 out of 24.78

Confidence: medium

Additional weak hits (2):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.85 out of 32.93

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NC_011900.1 - Region 4 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 1,069,690 - 1,090,565 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase

SPN23F_RS05580: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthetase

SPN23F_RS05605: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001595.3	0.26	other (other)	fischerindole	Fischerella sp. SAG 46.79
BGC0000668.5	0.26	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001595.3	0.26	other (other)	fischerindole	Fischerella sp. SAG 46.79
BGC0000668.5	0.26	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

SPN23F_RS05605: PT_FPPS_like

Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.35 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.19 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.20 out of 24.78

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NC_011900.1 - Region 5 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,226,969 - 1,250,220 nt. (total: 23,252 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

SPN23F_RS06430: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000516.4	0.48	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.3	0.47	ribosomal	suicin 3908	Streptococcus suis
BGC0000626.3	0.46	ribosomal	thuricin	Bacillus thuringiensis
BGC0000539.5	0.46	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000516.4	0.48	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.3	0.47	ribosomal	suicin 3908	Streptococcus suis
BGC0000626.3	0.46	ribosomal	thuricin	Bacillus thuringiensis
BGC0000539.5	0.46	ribosomal	nukacin ISK-1	Staphylococcus warneri

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for SPN23F_RS06430

SPN23F_RS06435

Leader:

MSDWKKPIYESLSTEGNPAGDILRELSDSEMDQAMAGG

Core:

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

Core with dehydrations:

DhbARDhaYCysACysYDhaGEHDhaCysGRGCysDhbIDhbDhbECysPFLDhbFICysCys

antiSMASH-DB 4.0 matches for SPN23F_RS06435

100.0%

NC_011900.1and 2 others:

NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptideNZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide

Lanthipeptides: SPN23F_RS06435_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

97.0%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01500_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TARSYC CYSGEHSCGRGCTITTECPFLTFICC

1

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

33

97.0%

NZ_JVCZ01000028.1:

Lanthipeptides: ADG88_RS11420_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TARSYCACYSGE+SCGRGCTITTECPFLTFICC

1

TARSYCACYSGENSCGRGCTITTECPFLTFICC

33

with 44 more sequence matches

Only the first 10 are displayed here.

76.5%

NZ_LR595858.1:

Lanthipeptides: FQT45_RS03330_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA SYC CYSG+ SCGRGCTITTECP T ICC

2

TANSYCHCYSGKDSCGRGCTITTECPIATIICC

34

72.7%

NZ_FQTY01000002.1:

Lanthipeptides: BUB33_RS04605_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA SYC CYS + SCG GCTITTECP T ICC

1

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

33

70.6%

NZ_GG666304.1:

Lanthipeptides: HMPREF0077_RS09155_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA ++C CYSG+ SCG GCTITTECPF T ICC

2

TANTHCHCYSGKDSCGHGCTITTECPFATLICC

34

70.6%

NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA +YC CYSG+HSCGR CT+TTECP T ICC

2

TANTYCHCYSGKHSCGRACTVTTECPIATIICC

34

69.7%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA +YC CYSG HSCGR CTIT ECP T CC

1

TANTYCRCYSGRHSCGRACTITAECPVFTVACC

33

67.6%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA +YC CYSG+ SCGR CTITTECP T +CC

2

TANTYCHCYSGKDSCGRRCTITTECPIATVVCC

34

58.8%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

33

TA ++C CYS + SCGR CT T ECP +T ICC

2

TANTHCNCYSEDASCGRLCTGTAECPIMTIICC

34

52.9%

NZ_LMFO01000023.1:

Lanthipeptides: allorf_629531_629758_lanthipeptide

1

TARSYCACYSGEHSCGRGCTITTECPFLTFIC

32

+ +Y +CYS + SCG CT TTECPFL+F C

3

SPNTYNSCYSKQKSCGNFCTFTTECPFLSFCC

34

33.3%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

14

SCGRGCTITTECPFLTFIC

32

S G CT+T EC TFIC

2

SSGWFCTLTIECG--TFIC

18

33.3%

NZ_CP048273.1and 3 others:

NZ_CP048273.1 Lanthipeptides: M654_RS18555_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11280_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11275_lanthipeptide

Lanthipeptides: M654_RS18560_lanthipeptide

15

CGRGCTITTECPFLTFICC

33

CG CTIT +CP F+CC

3

CGWACTITDDCPNSVFVCC

21

MIBiG 4.0 matches for SPN23F_RS06435

18.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GRGCTITTEC

25

G CT+T EC

14

GAYCTLTVEC

23

18.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

GRGCTITTEC

25

G CT+T EC

16

GGWCTLTKEC

25

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTITTEC

25

CT++ EC

28

CTLSKEC

34

allorf_1227297_1227521

Leader:

MLKCFIILTLYKHYTFVIQILTLLGTIKNHENFNLHVTGQCLKKSTLNLLKFLFVELEYIYLA

Core:

HICFLKASVGF

Core with dehydrations:

HICysFLKADhaVGF

antiSMASH-DB 4.0 matches for allorf_1227297_1227521

100.0%

NC_011900.1:

Lanthipeptides: allorf_1227297_1227521_lanthipeptide

1

HICFLKASVGF

11

HICFLKASVGF

1

HICFLKASVGF

11

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.05 out of 18.16

Confidence: strong

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 28.90 out of 29.25

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

Additional weak hits (3):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.22 out of 31.73

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.28 out of 35.63

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.18 out of 19.52

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

SPN23F_RS06435 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 3438.5 Da

Molecular weight: 3440.9 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3459.0 Da N = 1

allorf_1227297_1227521 - Class II

Cleavage pHMM score: -3.60

RODEO score: 0

Monoisotopic mass: 1202.6 Da

Molecular weight: 1203.5 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
SypG	Regulator of biofilm formation and host colonization

NC_011900.1 - Region 6 - T3PKS

Download region GenBank file

Download region SVG

Location: 1,650,757 - 1,691,929 nt. (total: 41,173 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

SPN23F_RS08715: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: formyltransferase methyltransferase phosphotransferase

SPN23F_RS08695: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

SPN23F_RS08765: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

SPN23F_RS08825: methyltransferase

smcogs: SMCOG1248: methyltransferase

Hydrolases: hydrolase

SPN23F_RS08835: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

SPN23F_RS08720: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002111.3	0.42	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002111.3	0.42	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.14 out of 20.97

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.40 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 27.71 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.06 out of 26.06

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.33 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.53 out of 27.18

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.07 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes

NC_011900.1 - Region 7 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,898,536 - 1,921,526 nt. (total: 22,991 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

SPN23F_RS10075: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

SPN23F_RS10055: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.60	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.49	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.60	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.49	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for SPN23F_RS10055

SPN23F_RS10045

Leader:

MTNFNSNEKFCGKSLKSLSADEMSLIYGA

Core:

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

Core with dehydrations:

DhaDGAEPRWDhbPDhbPIILKDhaAAADhaDhaKVCysIDhaAAVDhaGIGGLVDhaYNNDCysLG

antiSMASH-DB 4.0 matches for SPN23F_RS10045

100.0%

NC_003028.3and 39 others:

NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptideNZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide

Lanthipeptides: SP_RS09790_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

97.8%

NZ_CP035244.1and 3 others:

NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide

Lanthipeptides: EQH36_RS09100_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTPIILKSAAASSK+CISAAVSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG

45

95.6%

NZ_JALDUX010000010.1:

Lanthipeptides: M1F92_RS09530_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTP+ILKSAAASSKVCISA VSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

45

with 20 more sequence matches

Only the first 10 are displayed here.

91.1%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTP ILKSA ASSKVCISA VSGIGG+VSYNNDCLG

1

SDGAEPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNNDCLG

45

84.4%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06300_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEP WTPTP ILKSAA SSKVCISA +SGIGG+ SYNNDCLG

1

SDGAEPLWTPTPTILKSAARSSKVCISAIISGIGGIFSYNNDCLG

45

77.8%

NZ_CMKL01000017.1:

Lanthipeptides: AD734_RS09115_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

35

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

35

54.3%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14400_lanthipeptide

5

EPRWTPT--PIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EPR TPT P I + SSKVC+S S IGG+ S+NNDCLG

4

EPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG

46

54.3%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08660_lanthipeptide

5

EPRWTPTPI--ILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

+PR TPT + I++S A SSKVCISA S I G+VS N +CLG

4

DPRATPTIVASIIRSVAQSSKVCISAVGSAISGIVSNNKNCLG

46

53.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EP TP IL +A SSK C+ A+S I GLVSYN DCLG

5

EPHTTP---ILSAATKSSKKCL-GAISAISGLVSYNKDCLG

41

51.1%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25230_lanthipeptide

5

EPRWTPTPIILKSAAASS-KVCISAAVSGIGGLVSYNNDCLG

45

+PRWTP ++AA S K+CISA S IGG+VSYN +C G

4

DPRWTPIASAAINSAARSSKICISAVGSAIGGIVSYNKNCAG

45

48.9%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EPR TP I+ + SSK CISA S I G++S+N DCLG

4

EPRGTPATIV-SAVTRSSKPCISAIGSAISGIISHNKDCLG

43

48.9%

NZ_KB976303.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide

Lanthipeptides: IGY_RS26045_lanthipeptide

3

GAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

G + R PT I++ + ASSK C+S VS I GL+SYN DC+G

2

GVDTRTHPTVIVV--SRASSKACMSG-VSAISGLLSYNKDCIG

41

46.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

4

AEPRWTP-TPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

A+PRWTP +L + S+++CIS S I G+VS+N DCLG

3

ADPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG

45

MIBiG 4.0 matches for SPN23F_RS10045

8.9%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

11

TPIILKSAAASSKVCI

26

TP + + S +C+

5

TPTVAQFVIQGSTICL

20

SPN23F_RS10050

Leader:

MKNDFVIGKSLKELSLEEMQLVYGG

Core:

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

Core with dehydrations:

DhbDGADPRDhaDhbIICysDhaADhbLDhaFIADhaYLGDhaAQDhbRCysGKDNKKK

antiSMASH-DB 4.0 matches for SPN23F_RS10050

100.0%

NC_003028.3and 45 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

97.3%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06305_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRS+IICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSSIICSATLSFIASYLGSAQTRCGKDNKKK

37

97.3%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRST ICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSTTICSATLSFIASYLGSAQTRCGKDNKKK

37

with 20 more sequence matches

Only the first 10 are displayed here.

70.3%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00310_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

36

AD RST ICSA +SFIA+YLGSA T CGKDNKK

5

ADVRSTPICSAGISFIATYLGSAATNCGKDNKK

37

59.5%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23820_lanthipeptide

2

DGADP--RSTIICSATLSFIASYLGSAQTRCGKDNKK

36

DG D RST+IC SFI SYL SA +CGK NKK

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

56.8%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SAQ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAQYRCGKDNKGK

35

56.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

36

D RS+++CSA LSF+ SYL SA +CGKDNKK

4

VDVRSSLVCSALLSFVGSYLASAGLKCGKDNKK

36

56.8%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SAQ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAQFRCGKDNKGK

35

55.3%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25235_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

A+ RST+IC A +S I SYL SA +CGKDNK K

5

AEARSTLICGAGISLIGSYLASAAFKCGKDNKGK

38

54.1%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SA+ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAEFRCGKDNKGK

35

51.4%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08665_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

A+ RST++C +SF+ASYL SA +CGKDNK

5

AEVRSTLLCGMGISFVASYLASAAFKCGKDNK

36

51.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SA+ +CGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAEFKCGKDNKGK

35

48.6%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

G PR+T + SF+ASY+ SA+ RCGKDNK

2

GVTPRTTPATTLLASFVASYIASAEFRCGKDNK

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.81 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.84 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78

Confidence: medium

Additional weak hits (4):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.04 out of 30.11

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 23.43

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

SPN23F_RS10045 - Class II

Cleavage pHMM score: -0.40

RODEO score: 0

Monoisotopic mass: 4313.2 Da

Molecular weight: 4315.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4333.9 Da N = 1; 4351.9 Da N = 2; 4369.9 Da N = 3; 4387.9 Da N = 4; 4405.9 Da N = 5; 4424.0 Da N = 6; 4442.0 Da N = 7

SPN23F_RS10050 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 3741.0 Da

Molecular weight: 3743.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3761.2 Da N = 1; 3779.2 Da N = 2; 3797.3 Da N = 3; 3815.3 Da N = 4; 3833.3 Da N = 5; 3851.3 Da N = 6; 3869.3 Da N = 7

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NC_011900.1 - Region 8 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1,945,306 - 1,955,602 nt. (total: 10,297 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000571.3	0.36	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000513.3	0.36	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.36	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000500.5	0.35	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000571.3	0.36	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000513.3	0.36	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.36	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000500.5	0.35	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

Additional weak hits (1):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.05 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis