LOCUS       NC_011900              23252 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Streptococcus pneumoniae ATCC 700669, complete sequence.
ACCESSION   NC_011900
VERSION     NC_011900.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptococcus pneumoniae ATCC 700669
  ORGANISM  Streptococcus pneumoniae ATCC 700669
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Croucher,N.J., Walker,D., Romero,P., Lennard,N., Paterson,G.K.,
            Bason,N.C., Mitchell,A.M., Quail,M.A., Andrew,P.W., Parkhill,J.,
            Bentley,S.D. and Mitchell,T.J.
  TITLE     Role of conjugative elements in the evolution of the
            multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F
            ST81
  JOURNAL   J Bacteriol 191 (5), 1480-1489 (2009)
   PUBMED   19114491
REFERENCE   2  (bases 1 to 2221315)
  AUTHORS   Croucher,N.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-SEP-2008) Croucher N.J., Pathogen Genomics, Wellcome
            Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
            Cambridge, Cambridgeshire, CB10 1SA, UNITED KINGDOM
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 00:47:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,268
            CDSs (total)                      :: 2,195
            Genes (coding)                    :: 2,039
            CDSs (with protein)               :: 2,039
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 156
            CDSs (without protein)            :: 156
            Pseudo Genes (ambiguous residues) :: 0 of 156
            Pseudo Genes (frameshifted)       :: 82 of 156
            Pseudo Genes (incomplete)         :: 70 of 156
            Pseudo Genes (internal stop)      :: 58 of 156
            Pseudo Genes (multiple problems)  :: 45 of 156
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:23:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1226968
            Orig. end                         :: 1250220
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FM211187.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23252
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="5"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23252
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23252
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13252](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13252)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    290..310
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 25.28"
                     /tool="antismash"
     CDS             329..553
                     /gene="allorf_1227297_1227521"
                     /locus_tag="allorf_1227297_1227521"
                     /protein_id="allorf_1227297_1227521"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLKCFIILTLYKHYTFVIQILTLLGTIKNHENFNLHVTGQCLKKS
                     TLNLLKFLFVELEYIYLAHICFLKASVGF"
     CDS_motif       329..517
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLKCFIILTLYKHYTFVIQILTLLGTIKNHENFNLHVTGQCLKKSTLNLLKFLFVELEY
                     IYLA"
                     /locus_tag="allorf_1227297_1227521_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       518..553
                     /prepeptide="core"
                     /locus_tag="allorf_1227297_1227521_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.60"
                     /molecular_weight="1203.5"
                     /monoisotopic_mass="1202.6"
                     /core_sequence="HICFLKASVGF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLKCFIILTLYKHYTFVIQILTLLGTIKNHENFNLHVTGQC
                     LKKSTLNLLKFLFVELEYIYLA"
                     /leader_location="[328:517](+)"
     misc_feature    complement(437..452)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.18"
                     /tool="antismash"
     gene            complement(995..1714)
                     /gene="catA"
                     /locus_tag="SPN23F_RS06375"
                     /old_locus_tag="SPN23F12590"
                     /old_locus_tag="SPN23F_12590"
                     /pseudo=""
     CDS             complement(995..1714)
                     /codon_start=1
                     /gene="catA"
                     /gene_functions="resistance (resist) Chlor_Acetyltrans_CAT"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032488880.1"
                     /locus_tag="SPN23F_RS06375"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12590"
                     /old_locus_tag="SPN23F_12590"
                     /product="type A chloramphenicol O-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQE
                     GYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYWDKLEPLYTIFDGVSKTFSGIWTPV
                     KNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNSNYL
                     LPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL"
     gene            complement(1885..2133)
                     /locus_tag="SPN23F_RS06380"
                     /old_locus_tag="SPN23F12600"
                     /old_locus_tag="SPN23F_12600"
     CDS             complement(1885..2133)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814254.1"
                     /locus_tag="SPN23F_RS06380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12600"
                     /old_locus_tag="SPN23F_12600"
                     /product="hypothetical protein"
                     /protein_id="WP_001814254.1"
                     /transl_table=11
                     /translation="MNYQKLNDITGATKNEKDKYYVYGLYEEGKQLPFYIGKGEGTRLI
                     SHIDEALTEINQEENIQISKKIQIIRKHKGKIIPVII"
     gene            complement(2372..3160)
                     /locus_tag="SPN23F_RS06385"
                     /old_locus_tag="SPN23F12610"
                     /old_locus_tag="SPN23F_12610"
     CDS             complement(2372..3160)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000214003.1"
                     /locus_tag="SPN23F_RS06385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12610"
                     /old_locus_tag="SPN23F_12610"
                     /product="hypothetical protein"
                     /protein_id="WP_000214003.1"
                     /transl_table=11
                     /translation="MTTTKNPWNQLSNVDINGEQAILATEDVELIKKYTSTKHYKNLKD
                     DIYRLQLGFCPQQFVGDIQNADIIVLSKNPGYTPEFKTLYDHDKNYQKTLLNNLQLKGN
                     LYFHAFDLDTNEFGYWAKKFKVWFDDVDNLQDLKEKLPWFSKHVALAEYFPYYSTKYDD
                     KLNDFISKEGYFPTQKFLFNLIRERVLDDNDPVIIIITRSYNKWYDAIPQLKEYKNCYE
                     TSNPSNPSLKPENLLKVKRYSAKKEVEKVLEDSLKKLEHK"
     gene            complement(3636..4394)
                     /gene="pezT"
                     /locus_tag="SPN23F_RS06390"
                     /old_locus_tag="SPN23F12620"
                     /old_locus_tag="SPN23F_12620"
     CDS             complement(3636..4394)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="pezT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042596.1"
                     /locus_tag="SPN23F_RS06390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12620"
                     /old_locus_tag="SPN23F_12620"
                     /product="type II toxin-antitoxin system toxin PezT"
                     /protein_id="WP_000512672.1"
                     /transl_table=11
                     /translation="MGIQDYTDSQFKQALARNIRSLTRGKKSSKQPIAILLGGQSGAGK
                     TTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQEYGKDSVEYTKYFAGKMVESLVRE
                     LSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEELYA
                     INPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAAD
                     VLQELLFGEWSQVEKDMLKSGEERLKDLTN"
     gene            complement(4394..4870)
                     /gene="pezA"
                     /locus_tag="SPN23F_RS06395"
                     /old_locus_tag="SPN23F12630"
                     /old_locus_tag="SPN23F_12630"
     CDS             complement(4394..4870)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="pezA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042293.1"
                     /locus_tag="SPN23F_RS06395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12630"
                     /old_locus_tag="SPN23F_12630"
                     /product="type II toxin-antitoxin system antitoxin PezA"
                     /protein_id="WP_000579607.1"
                     /transl_table=11
                     /translation="MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTEL
                     IDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGISI
                     DDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEIFEKRMAA"
     gene            complement(4940..5212)
                     /locus_tag="SPN23F_RS06400"
                     /old_locus_tag="SPN23F12640"
                     /old_locus_tag="SPN23F_12640"
     CDS             complement(4940..5212)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399544.1"
                     /locus_tag="SPN23F_RS06400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12640"
                     /old_locus_tag="SPN23F_12640"
                     /product="hypothetical protein"
                     /protein_id="WP_000494445.1"
                     /transl_table=11
                     /translation="MFTKLFKKNQDNSDVFKKLIHRLSDMSIQDLKKIDRLLDIIFTPD
                     QGSEQLKTEATYREETLDDTLKEAKNQLHMEQLEKNLERFRKNSQ"
     gene            complement(5250..5633)
                     /locus_tag="SPN23F_RS06405"
                     /old_locus_tag="SPN23F12650"
                     /old_locus_tag="SPN23F_12650"
     CDS             complement(5250..5633)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159213.1"
                     /locus_tag="SPN23F_RS06405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12650"
                     /old_locus_tag="SPN23F_12650"
                     /product="DUF5945 family protein"
                     /protein_id="WP_000159218.1"
                     /transl_table=11
                     /translation="MTKDWNFNQPLESKSENQEDPDKIAALFGNHQGGNEVNYEAAFQK
                     RKQAPVTESNSSSKPKVTEVRTGKETDITTSYQQHLKRLIADNNSDIQSSQKKIEELHT
                     LIDTKNKDNKKLQSIYDAISELH"
     gene            complement(5630..5863)
                     /locus_tag="SPN23F_RS06410"
                     /old_locus_tag="SPN23F12660"
                     /old_locus_tag="SPN23F_12660"
     CDS             complement(5630..5863)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152421.1"
                     /locus_tag="SPN23F_RS06410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12660"
                     /old_locus_tag="SPN23F_12660"
                     /product="DUF5965 family protein"
                     /protein_id="WP_000152419.1"
                     /transl_table=11
                     /translation="MTIIERLEEKVTRQESKVARETEKLAAYKEQLETAMFATFKRRQS
                     ISHMSFEEALDHAFGKERQFDDSEFRKDEMSE"
     gene            complement(5914..6999)
                     /locus_tag="SPN23F_RS06415"
                     /old_locus_tag="SPN23F12670"
                     /old_locus_tag="SPN23F_12670"
     CDS             complement(5914..6999)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590072.1"
                     /locus_tag="SPN23F_RS06415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12670"
                     /old_locus_tag="SPN23F_12670"
                     /product="toprim domain-containing protein"
                     /protein_id="WP_000401892.1"
                     /transl_table=11
                     /translation="MEIEECKKISILDVANRLGISFKQVSSSVYEHPEHDSFRIFSTTN
                     TFKWFSRDIQGDVIDFVRLVKGISFKEALAFLSEEPFQKEAVQEKRERPFYYPLKRIED
                     SNCSLARYYLTECRGISEEIIQKMIQQGLMSQASWKTNETVEPVIVFKSFDHRHKLQAA
                     SLQGIYKNHSLPRERLKTILKGSHGHVGISFDIGKPNRLVFCESFIDLMSYYELHQQNL
                     FDVRLVSMEGLKRSVVAYQTLRLIAEENQKLEFLDTVIPSKLLPLINTIRDTTSYFDNH
                     PDLLTLAVDCDDAGKDFSDKLSRSGFPVFLDLPDNESGKEKRDWNDILREKKSDLQLMI
                     ENAKETLRNQPVRQTSQCLEL"
     misc_feature    6969..6985
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.22"
                     /tool="antismash"
     gene            complement(7009..7650)
                     /locus_tag="SPN23F_RS06420"
                     /old_locus_tag="SPN23F12680"
                     /old_locus_tag="SPN23F_12680"
     CDS             complement(7009..7650)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933080.1"
                     /locus_tag="SPN23F_RS06420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12680"
                     /old_locus_tag="SPN23F_12680"
                     /product="hypothetical protein"
                     /protein_id="WP_000933090.1"
                     /transl_table=11
                     /translation="MLNKVKTKALISVGAVAATSFILMVGYTIGQHSTAKQSRKEIELA
                     ATKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELSSQN
                     DAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTNQTETRT
                     VKLSYSKLPGKLLVNQVQVWKSGLDDLDKVTPKTLEESSSIPSLPNTTTK"
     misc_feature    7700..7715
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            complement(7871..9994)
                     /locus_tag="SPN23F_RS06425"
                     /old_locus_tag="SPN23F12690"
                     /old_locus_tag="SPN23F_12690"
     CDS             complement(7871..9994)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756060.1"
                     /locus_tag="SPN23F_RS06425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12690"
                     /old_locus_tag="SPN23F_12690"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000756060.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.7e-29, bitscore:
                     99.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVKFIQQLSETSCGLACMAMILDYYGHEANLYELCCDFENSRD
                     GLSIREIKDIASYFGLDSKATEILNIKKFLGNKFVEPYIALTQNAHYIVVEKHNEHSVV
                     FIDPERGRITEDISNFANNISGIVIFFSPNRKFTKKKKHSNFFKILKIGKIDIKRLCYI
                     SLISILVQSLTLLLPLLTRFIIDNVISKGEMYRLGMLFSIFSLITFYALFSFIRTKLII
                     TVEKRYIFTLKDKIVGKIFTLPMKFFDSRSSGEIVTRINNLDSLEKIISSGISSLLIDL
                     STIIIAFIAMAMISLYFTLIITCFAIFLFIVLYFLLKKLEEKNSNFISSKELTQGYLME
                     IFSNLLFLKVSAKGDVSYTKWKEMFSNELKFDVERENYLNIFQTFISIYRLVPNLLILI
                     LGGLEVQQHMMSLGSLMSFLSLVSLLLSPITLIVQNCFQFQFCFTILDRVFDIIYTPEE
                     KNQFSISKLPPFEMMTFRNLSFAYSSACKVIYDISLTIKKGERIAIVGRTGCGKTTLIK
                     LLLRLYDVEKNTILYNGNDINLFDLNSYRKSFGVVLQNDVMFNDTVISNIDLTHSHSME
                     DVISAASLAELDIEINNMPMGYYTSIGDNGNNLSGGQRQRLAIARAILQNPEIIIFDEG
                     TGQLDTITEKKIMDNLKHKGITQIFITHRLSNAQEYDNIIVMDNGKIIDSGKHDELCGK
                     EGMYKRLFETSYN"
     gene            complement(10001..13252)
                     /locus_tag="SPN23F_RS06430"
                     /old_locus_tag="SPN23F12700"
                     /old_locus_tag="SPN23F_12700"
     CDS             complement(10001..13252)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001080431.1"
                     /locus_tag="SPN23F_RS06430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12700"
                     /old_locus_tag="SPN23F_12700"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_001080431.1"
                     /sec_met_domain="DUF4135 (E-value: 1.4e-106, bitscore:
                     353.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.7e-64, bitscore:
                     214.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRKLNITDFKDASYFSERKISSHDLGDGLKSRKRKEYWDNFIGE
                     GSNEFWKYLQEKNDFSKHDLDIFLEEHTYDVKDIDSFSHMDEFIEFFFKRNDYTLPEFY
                     IVDSEGKRKPIFSNFVIPFLKFAAYKLEDNLSSQNLKVTRDVLNSLLIALFQQILNISY
                     RTLILELQVLKEQNMLKGETGEKRFKYFSEIYLSDHFWDILKEYPVMFRLIIENIQNWV
                     TNNVEFLTNLKEDKALLQEHFSINGELTKIESGVSDFHNHGKSVYLLWFGTNKLVYKPR
                     DLILDVKFQNLLSWYNLKFNKNLYVTNILNRGNYGWVEYIEHLPCTYESDFIQFYTHLG
                     YLLFLLFAMRGNDIHFENIIAKGNRPVLVDIETLFHNTTEYRKEYETADKLIFSLLEKS
                     VKRVGILPNIVWGKDGNSGVDISGLSSSAGEMIPIERASIMHSMTDEMKIGYEQSALQS
                     KDNQPFIQSGKDVDLNSYKNYVSAGFKEAYEIISKDPSSIEEFLVEIEKFNNAYSRQIM
                     RPTQFYSNLIQTSYHPSFLRSGLDREMLFSKVWKIVFEDKKVQRIASSEFESLLLGDIP
                     LFQTKISDRFLCSELTKYQNFFNISGMELAIQQIKDFCQKDMEFQLNLIETTLNYDPSY
                     NLVQDSFVPLKPSVKVIRNLNQKEIQETKSRIVPLTEKIADYLSKISYSGTSGDICWVD
                     MNILGEKTNDWNMVPIGCDLYNGISGIMLFYLFLYLETKKKDYLIYLKKCYRSLKYYLD
                     SRKQFATHSQVLFGGFSGETPIIYVLLLLKTRMPEHFNSDELDVYIYDIIDDLKKGYRY
                     DENFDVLVGSAGAIIHLLNVFEVTRDEELLILAHDLFSHLEKNSTKITVEGQDGRAWKG
                     TMASNPLAGFAHGVSGIVWALSKLSRYFPEDKKLKTIIKQGIIFENSMFDTEKSNWSDY
                     RETESGIKYKDIVENIPVSWCHGAPGILISRLELYKNNTLNVEFRRTMKSDMDVAIDTT
                     IKYGFGKSHCLCHGDLGNLNILFYVAKKMSSEHLYNVVYSYLNTILDDLESENWKCGLP
                     YKNSPSLMSGIAGIGLGLLTLNNLSIPSVINLEIW"
     gene            complement(13335..13550)
                     /locus_tag="SPN23F_RS06435"
                     /old_locus_tag="SPN23F12701"
                     /old_locus_tag="SPN23F_12701"
     CDS             complement(13335..13550)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="SPN23F_RS06435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12701"
                     /old_locus_tag="SPN23F_12701"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_001286517.1"
                     /transl_table=11
                     /translation="MSDWKKPIYESLSTEGNPAGDILRELSDSEMDQAMAGGTARSYCA
                     CYSGEHSCGRGCTITTECPFLTFICC"
     CDS_motif       complement(13437..13550)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSDWKKPIYESLSTEGNPAGDILRELSDSEMDQAMAGG"
                     /locus_tag="SPN23F_RS06435_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13335..13436)
                     /prepeptide="core"
                     /locus_tag="SPN23F_RS06435_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.20"
                     /molecular_weight="3440.9"
                     /monoisotopic_mass="3438.5"
                     /core_sequence="TARSYCACYSGEHSCGRGCTITTECPFLTFICC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDWKKPIYESLSTEGNPAGDILRELSDSEMDQAMAGG"
                     /leader_location="[13436:13550](-)"
                     /alternative_weights="3459.0"
     gene            complement(13695..14423)
                     /locus_tag="SPN23F_RS06440"
                     /old_locus_tag="SPN23F12710"
                     /old_locus_tag="SPN23F_12710"
     CDS             complement(13695..14423)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000928810.1"
                     /locus_tag="SPN23F_RS06440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12710"
                     /old_locus_tag="SPN23F_12710"
                     /product="ABC transporter permease"
                     /protein_id="WP_001814255.1"
                     /transl_table=11
                     /translation="MLMLEFTKLRRRKILYMIPFVAILLFLLEFMIGHQIYQGHSYGSV
                     NGWYVENGFFFLNYYFLLPFASMILVDLIRIEQVSKTISNLRLIPVDLKQLLQAKFMLA
                     LLINLLVSEFTFLAMLVLELMDGDFAFSSLAMLSWGVVYGAIAFAYTLSAGIIVLFLGK
                     YRKELILALPLAFLLSFAGLFALTTVVGRYYLANLLLIIMEQFTALTVSVYAIWLVTLV
                     ACLLYLLADKRMMNIIFAYK"
     gene            complement(14424..15173)
                     /locus_tag="SPN23F_RS06445"
                     /old_locus_tag="SPN23F12720"
                     /old_locus_tag="SPN23F_12720"
     CDS             complement(14424..15173)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="SPN23F_RS06445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12720"
                     /old_locus_tag="SPN23F_12720"
                     /product="ABC transporter permease"
                     /protein_id="WP_224781690.1"
                     /transl_table=11
                     /translation="MRELLDLVKIEFLKQRHQKLNFVVYGVVSLYLALICYYVNDARGL
                     FDSFPFVYKFSLSYLNFLILPLYCVSYTIQAFGLEYRYRIMNNLKLASANLMKTFWAKI
                     LYIEINALCIMLFTYISVSLFALLSRFSSTVSLSLLLRFFYLCMSSGILIPMGVFPLVA
                     LVMIKVRGKEIVGNLVGVMYVLVSFFLARTSPNISPVTSANSLIWEGNREGVVLQQPAI
                     LSIVVLGLSLLVLSFLSIKSWLRKVDE"
     gene            complement(15157..16092)
                     /locus_tag="SPN23F_RS06450"
                     /old_locus_tag="SPN23F12730"
                     /old_locus_tag="SPN23F_12730"
     CDS             complement(15157..16092)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245733.1"
                     /locus_tag="SPN23F_RS06450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12730"
                     /old_locus_tag="SPN23F_12730"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001245731.1"
                     /transl_table=11
                     /translation="MRNPVIQTFNLSKSYDGKIVLDRIDFTLRQGEIYGLLGRNGTGKT
                     TFIKAILGLTAMDSGEVNILSEKLLGEFSKDLLSQIGVVLDSASFYPNLTGPENLSIFA
                     RLRGISLKQVEQALQVVGLDGENKKLFKQYSLGMKQRLAIANAIMHQPKILILDEPTNG
                     LDPIGILEMRRYLKELSTNHGISILISSHIISELEKLVDRVGILHDAHLMAEKTMKELI
                     DGADKRKIHLIVSDAPQAKEVLCRINLQEQISILSDIELELQGESPTFDIAVVSNSLKD
                     NGIVLKEYSYKNNESLEDYFKRITGGEGIA"
     gene            complement(16270..16443)
                     /locus_tag="SPN23F_RS13560"
                     /old_locus_tag="SPN23F12740"
     CDS             complement(16270..16443)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000025229.1"
                     /locus_tag="SPN23F_RS13560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12740"
                     /product="hypothetical protein"
                     /protein_id="WP_000025229.1"
                     /transl_table=11
                     /translation="MSILAKFRKIIFMLSFLGLFGSGFFFKEPVNQSQYTWESRIIQQA
                     VTTNEVDLGLAD"
     gene            16634..17494
                     /locus_tag="SPN23F_RS06460"
                     /old_locus_tag="SPN23F12750"
                     /old_locus_tag="SPN23F_12750"
     CDS             16634..17494
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000025784.1"
                     /locus_tag="SPN23F_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12750"
                     /old_locus_tag="SPN23F_12750"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_000154111.1"
                     /transl_table=11
                     /translation="MTILSDKLKAKRKEKGFSQKTLSEGICEQSQISKIERGNYMPAAD
                     LLYKLANRLQVPLDYFFDEQIEMTSNITPFKKLAEKLLEDRNYEDLEYLLNLEKEKSQY
                     LSTEDEFYLLWIQSIILFYLHSSKDEAIASLENALPKLSVSSSVYLKLLNTLSNFYFSV
                     GRDAEYEENNSLLISLYQEKDLNHQEYLFGYIRVKHNFAYYLHSKGKELEAVQEALETI
                     DFCKQKETSYQLAPLLTIVANAGKDFLKHDEILDYYLQARDICKIYEHKLMMAKIDHFL
                     KDKDR"
     gene            complement(17577..17867)
                     /locus_tag="SPN23F_RS06465"
                     /old_locus_tag="SPN23F12760"
                     /old_locus_tag="SPN23F_12760"
     CDS             complement(17577..17867)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000998897.1"
                     /locus_tag="SPN23F_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12760"
                     /old_locus_tag="SPN23F_12760"
                     /product="DUF5966 family protein"
                     /protein_id="WP_000998897.1"
                     /transl_table=11
                     /translation="MNDLLLIPVIFLAVGGILILLWRLFLIASGLFLIGFVSFLIFVEV
                     YGIYLLFTETELYTADLAQNGLFGFTTFFIIFNLVLLALACWAGYKWKRGY"
     gene            complement(17881..18165)
                     /locus_tag="SPN23F_RS06470"
                     /old_locus_tag="SPN23F12770"
                     /old_locus_tag="SPN23F_12770"
     CDS             complement(17881..18165)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263534.1"
                     /locus_tag="SPN23F_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12770"
                     /old_locus_tag="SPN23F_12770"
                     /product="DUF5962 family protein"
                     /protein_id="WP_000969642.1"
                     /transl_table=11
                     /translation="MMEDTYYQLEEALVQGFQTPEEYQAYKELKEHYEEVTGDYSFSKR
                     ELTSQLEIALQNHRGVDFEEYEKKDYLELVQKLEEFDSSLATHYRQLID"
     gene            complement(18240..>19184)
                     /locus_tag="SPN23F_RS06475"
                     /pseudo=""
     CDS             complement(18240..>19184)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453515.1"
                     /locus_tag="SPN23F_RS06475"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="helicase SNF2"
                     /pseudo=""
                     /transl_table=11
                     /translation="QRNGRIIRQGNENKEVDIYHYITKGSFDNYLWATQENKLRYIKQI
                     MTSKEPIRAAEDIDEQTMTASDFKALATGNPYLKYKMELENDLTLLENQRRAFQRSKDH
                     YRHTISYCEENMPILEKRLSKYEGDIQQSEISKDQAFSMRVGKQSFDQRAEAGESLHRL
                     IRHNQADSKEFRTLASYRGFDIKMLSLPTNQPLPETFSVKIVGENQYSVSLDLYSPLGT
                     IQRLQHTIDHIKEDQVKTQNLLDELKDKWNTAKVEIEKNFPKEEDYQTKKAEYDVLAPL
                     IETETDLDTIDQALRQFHEKGKEKQEQLSFELD"
     gene            complement(19292..21103)
                     /gene="ltrA"
                     /locus_tag="SPN23F_RS06480"
                     /old_locus_tag="SPN23F12790"
                     /old_locus_tag="SPN23F_12790"
     CDS             complement(19292..21103)
                     /EC_number="2.7.7.49"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ltrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006740542.1"
                     /locus_tag="SPN23F_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F12790"
                     /old_locus_tag="SPN23F_12790"
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="WP_001245667.1"
                     /transl_table=11
                     /translation="MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYAN
                     PGHLTPGVDELTIDGMSIARIDQLIDSLKDESYQPHPSRRTYIPKKNGKLRPLGIPSFD
                     DKLLQQVIKMILEAIYEGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIKSFF
                     DNINHDVMIHILRERITDERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANI
                     YLDKFDKYMTDYVKNFCQGKYRKRTPEYRQNEIALGKARRALECVSTENQRQEVIQRIR
                     QLEKERVLIPHSDPMDSSFKRLTYTRYADDFICGVIGSKEDAHRIKADIKDYLEAVLKL
                     ELSVEKTLITNARDKAKFLGYHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDR
                     LLSYGAMKMTYHRGYEVWKPTARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILH
                     RFKYIMEYSMYKTYATKYRTTKSHIIRKYKKDGQFSVQYIGRKGDTMTRYLYNGGFKRQ
                     KKSFLENDNLPNTAKYFSRTNLIDRLKASRCEYCQATDSSLEIHHVRKLKDLKGKTFWE
                     RLMISRQRKTIALCKDCHKKLHHGKLD"
     misc_feature    complement(21149..21158)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.05"
                     /tool="antismash"
     misc_feature    22145..22159
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.5"
                     /tool="antismash"
     misc_feature    complement(22889..22903)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: strong, score: 28.9"
                     /tool="antismash"
ORIGIN
        1 atttaaagag gctaaaaaga aattaaaaaa tggggattta gattacttaa aagaaattga
       61 tccaaccgaa tatatctatc aaatttttta tatttggaaa caaaaagagt atttagctag
      121 tgaactttat gacttaacag aacaagaaaa aagagaaatt aatcacaaaa tgatagacga
      181 aatcgaggaa gaacaataac aaaatataag tgctaacagc tgacctcccg ataacaccat
      241 gtagttattg ggaggtcagc tgttgaatta tgcacgagta ttttaaaagt tattgtgatg
      301 acgacgataa acgattatca aaagtataat gttaaaatgc tttattatac taacgttata
      361 taaacattat actttcgtta tacaaatttt aaccctgtta ggaactataa aaaatcatga
      421 aaattttaat ttgcatgtaa ctgggcagtg tcttaaaaaa tcgacactga atttgctcaa
      481 atttttgttt gtagaattag aatatattta tttggctcat atttgctttt taaaagcttc
      541 tgtaggtttt taggcataaa actatatgat ttacccctaa atctttaaaa tgccccttaa
      601 aattcaaaat aaaggcattt aaaatttaaa tatttcttgt gataaagttt gttaaaaagg
      661 agtggtttta tgactgttat gtggttatcg attataggta tgtggttttg tattggaatg
      721 gcattttttg ctatcaaggt tattaaaaat aaaaattaga ccacgcattt atgccgagaa
      781 aatttattgt gcgttgagaa gaacccttaa ctaaacttgc agacgaatgt cggcatagcg
      841 tgagctatta agccgaccat tcgacaagtt ttgggattgt taagggttcc gaggctcaac
      901 gtcaataaag caattggaat aaagaagcga aaaaggagaa gtcggttcag aaaaagaagg
      961 atatggatct ggagctgtaa tataaaaacc ttcttcaact aacggggcag gttagtgaca
     1021 ttagaaaacc gactgtaaaa agtacagtcg gcattatctc atattataaa agccagtcat
     1081 taggcctatc tgacaattcc tgaatagagt tcataaacaa tcctgcatga taaccatcac
     1141 aaacagaatg atgtacctgt aaagatagcg gtaaatatat tgaattacct ttattaatga
     1201 attttcctgc tgtaataatg ggtagaaggt aattactatt attattgata tttaagttaa
     1261 acccagtaaa tgaagtccat ggaataatag aaagagaaaa agcattttca ggtataggtg
     1321 ttttgggaaa caatttcccc gaaccattat atttctctac atcagaaagg tataaatcat
     1381 aaaactcttt gaagtcattc tttacaggag tccaaatacc agagaatgtt ttagatacac
     1441 catcaaaaat tgtataaagt ggctctaact tatcccaata acctaactct ccgtcgctat
     1501 tgtaaccagt tctaaaagct gtatttgagt ttatcaccct tgtcactaag aaaataaatg
     1561 cagggtaaaa tttatatcct tcttgtttta tgtttcggta taaaacacta atatcaattt
     1621 ctgtggttat actaaaagtc gtttgttggt tcaaataatg attaaatatc tcttttctct
     1681 tccaattgtc taaatcaatt ttattaaagt tcatttgata tgcctcctaa atttttatct
     1741 aaagtgaatt taggaggctt acttgtctgc tttcttcatt agaatcaatc cttttttaaa
     1801 agtcaatatt actgtaacat aaatatatat attttaaaaa tatcccactt tatccaattt
     1861 tcgtttgttg aactaatggg tgctttaaat gattacaggt ataattttgc ccttatgttt
     1921 tctaataatt tgaatttttt tactaatttg tatgttttct tcttgattta tctctgtaag
     1981 cgcttcatcg atatgtgata ttaggcgagt tccctctcct ttaccaatat agaaaggtag
     2041 ttgcttacct tcttcataga gtccgtaaac atagtattta tctttttcat ttttggtagc
     2101 accagtaata tcatttaatt tttgataatt cattttttta ctcctattta aatatattat
     2161 aaaagttctg ctccatacta ttaaaaatta attaaaataa tcctcttatt ctaccttcat
     2221 tctgattctg aactatttat atgttaaact atattttctt taaaatcaag taaaatccta
     2281 gagaataatc taaataaatt tggggacaat atataggttt actaataact acacaataca
     2341 gtatttacga tagcattaaa aagagactgt tttatttatg ctctagcttt ttcaatgaat
     2401 cttctaatac tttttcaacc tcttttttag cagaatatcg tttgactttt aataaattct
     2461 caggttttaa agaaggatta ctaggattac tcgtttcata acaattttta tactctttta
     2521 attgaggaat tgcatcgtac cacttattgt aagatcgtgt gatgataatg attacaggat
     2581 cattgtcatc caaaacacgt tctctaatta aattgaataa aaacttttgt gttgggaaat
     2641 aaccttcttt gcttataaaa tcatttaatt tatcatcgta cttagtagag taatatggaa
     2701 aatattcagc taaagcaacg tgttttgaaa accaaggaag cttttctttt aaatcctgta
     2761 aattgtctac atcatcaaac catactttaa actttttagc ccagtaacca aattcattcg
     2821 tatctaggtc aaaagcatga aaatagaggt ttccttttag ctgtagatta tttaaaagag
     2881 tcttttggta gtttttatcg tggtcataaa gtgttttaaa ttcaggggtg tagccaggat
     2941 ttttagataa aacaatgata tcagcatttt gaatatcccc cacaaattgt tgcggacaaa
     3001 aacctaattg taaacggtag atatcatctt ttagattttt gtagtgtttt gtagaggtgt
     3061 attttttgat tagttcaaca tcttcggtag caagaatagc ttgctctcca tttatatcga
     3121 cgttagataa ttgattccag ggatttttag ttgtagtcat tttatttttc ctttcttttt
     3181 gtagaattac tatattttac gatgttttaa tattaaatac aaaaatagat tttattaata
     3241 tattctcgat tataaaagaa tctgagtgag gaaacgattt tgaatatcaa tagatataat
     3301 attatttata tcacctttca caccgccgta aatgatgttc ggaatacgtc ggctctacta
     3361 aactgtaacg aattctcatt gccaagtcta caaattattt tcaatactat aggccagata
     3421 gaattaacta aaaagtataa gactagtaca aaaagtccga taaattggaa atattttgag
     3481 aacaacgatt aatttaaaaa agaatgacgg tgagatttat tacttttatt tatactcact
     3541 ttgttagttt aattaaaagc cattttttta ccataatcta agagatagca atttttaata
     3601 ggctttattt taaaactcaa gatctaacaa ccatttcaat tagttaaatc tttcaatctt
     3661 tcttctccag atttaagcat atccttctct acttgactcc actccccaaa cagtaactct
     3721 tgaagaacat ctgccgctga agttgtattt tcttttgcat catatacaca acctctatct
     3781 cgttggtaaa tttgaattct ttcaaagata gctagttctt ccaattgtcg tgtattatca
     3841 actagatgat ttacaatgaa atcatgatgt tcttttggag ttgcgcgtgc ttgatttggg
     3901 ttaatagcgt acagttcttc gtatcggata agggtgctca gataggacag cttaggcttt
     3961 gtcgcaatca aggctaattg tatttcatat cccctacttt tcaagagttg tgctgttttc
     4021 tttggaacat caatagttcg taaagttccc tctatcaaaa gattgtatcc caaatgactc
     4081 aattctctta ctaaagactc taccatttta cctgcaaaat atttggtgta ttcaacactg
     4141 tctttgccat attcttgctg aagttctaaa tagtgtggat gctgagaacg aaaactatct
     4201 ccatctatga taacaatatt tccttgaaat tctttctgtt taatacgatg aattgtagtc
     4261 ttaccggcac cactttgccc tccgagcaaa atcgctatag gttgcttact ggactttttt
     4321 cctcttgtca gtgagcgaat gttccttgct aaagcctgtt taaattgact atcggtataa
     4381 tcttggattc ccattaggct gccatccgtt tttcaaatat ctctaacata cgttcaattc
     4441 catccaaata gccactatat ctctctattt catcaaaagt ttctactaaa tagatattcg
     4501 tatgaatcaa gtcagataga tcatcactca ttaaaatcca aggattagat tcatcatcaa
     4561 tgctaattcc ctgactatct tgataacgat agagtcgaga taatagatta gcacctcttt
     4621 ctttcacaat ttcaattttt aaagtcaatt cataatcttc aacaggattg agcattttat
     4681 cttctcctac aatatcgaca taagatacat taaacttctg acaaatgatg tctattaatt
     4741 cggtagagac tgaactcgtt ccattttcat aacgactcag actatttcgt gaaataccta
     4801 caatccgtgc aaattcgagt tgtgttaagt catgtgtttt acgcaaggat tttatgttct
     4861 ttccaatcat ggcaaactcc tttcatttga taccaccatt ataacattta gaaaaattaa
     4921 atgcaccaat tttggtgtgt tattgactat ttttcctaaa cctctctaaa ttcttctcca
     4981 attgttccat atgaagttga ttcttggctt cctttaatgt gtcgtccaaa gtttcttctc
     5041 tataagttgc ttctgttttt agttgttctg atccttgatc tggagtgaaa atgatatcta
     5101 acagtcgatc tattttttta agatcttgga tagacatatc agatagtcta tgaattagct
     5161 tcttaaatac atcactattg tcttggtttt tcttaaaaag ttttgtaaac atctataacc
     5221 tctcaaaaaa agcagccttt taagactgct tagtgtaatt ccgaaatcgc atcataaatg
     5281 gactgcaatt tcttattgtc tttattcttt gtgtcaatca aagtatgtag ctcttcaatt
     5341 ttcttttgac tactttgaat atcgctattg ttatctgcaa taagtctttt aagatgttgc
     5401 tgataacttg tagtgatatc tgtctctttt cctgttctaa cctctgtaac tttaggttta
     5461 gaactagaat ttgattccgt cacaggtgct tgtttacgct tttgaaaagc tgcttcataa
     5521 tttacctcat tacctccttg atgatttcca aataaggccg caattttatc tggatcttct
     5581 tgattttctg atttgctttc taatggttga ttaaaattcc aatcttttgt cattcactca
     5641 tttcatcctt tctaaattca gaatcatcga attgtctttc tttgccaaat gcatggtcaa
     5701 gagcttcttc aaaactcatg tgactaatgc tttgacgcct tttgaacgtc gcaaacatcg
     5761 ctgtctccag ttgctctttg taagcagcta gtttttctgt ctctcttgct accttgcttt
     5821 cttgcctagt gaccttttct tctaagcgtt caataatggt catatacgat cctccttcat
     5881 tctaatatta gctaaaacat cttgattttg ttatcacaat tctaaacatt gagatgtttg
     5941 tcttactggt tgattcctca atgtctcttt tgcattctcg atcatcaatt gtaaatctga
     6001 tttcttttct cgaagaatat cgttccagtc tcgtttttct ttcccagatt cattatcagg
     6061 taaatccaga aaaacaggaa atcctgatct agataactta tcagaaaaat ctttacctgc
     6121 atcatcacaa tctactgcca gtgtcaataa atcaggatga ttatcaaaat agctggtggt
     6181 atcacgaatt gtattgatca aaggcaataa ctttgaaggt attactgtat ctaaaaattc
     6241 caacttctga ttttcttcag ctatcagtcg taaagtttga taagcaacaa cagacctttt
     6301 taatccctcc atagatacca aacgaacatc aaatagattt tgttgatgaa gttcgtaata
     6361 gctcatcaag tcgataaacg attcacaaaa gaccagtcta tttggtttac caatgtcaaa
     6421 ggatattcca acatgtccgt ggcttccttt tagaatcgtt tttaacctct ctctaggaag
     6481 agagtgattc ttataaatcc cttgtaagct tgctgcctgc agtttgtgtc gatgatcaaa
     6541 gcttttaaaa acaataacag gttcaacagt ttcatttgtt ttccaactgg cttgtgacat
     6601 caaaccttgt tgaatcatct tttgtatgat ttcttctgaa attcctctac attctgttaa
     6661 ataatatctg gccagactac agttagaatc ttctattctc tttaaagggt aataaaatgg
     6721 tctctctctt ttttcttgaa cagcttcttt ttgaaaaggt tcttcagaaa gaaaggctag
     6781 agcttcttta aaggaaattc ccttaacaag tcgaacaaaa tcaatgacat caccttgaat
     6841 atctcttgaa aaccatttaa aagtattggt agttgaaaaa atccgaaatg aatcgtgttc
     6901 aggatgttca tagacactgc tcgaaacttg tttaaaggag atccccaaac gattggctac
     6961 atcaagaatt gaaattttct tacattcttc tatttccatg caacatcatc attttgtcgt
     7021 agtatttggc agtgatggta ttgatgatga ttcttctaaa gttttaggag ttaccttatc
     7081 taaatcatct aacccagatt tccaaacctg tacttgattg accaataact tacctggtag
     7141 tttcgaataa gacaacttaa ccgttctggt ttctgtctga ttagtctttg attggttggc
     7201 attctttaaa tcagatacat aggttacatt ataagagacc atggcaatag cttgattcgt
     7261 agtctgattg acaaagatat cagctttttc aaaatgataa tccaaaatat aatccttata
     7321 cacttggttc atggcatcat tttgacttga caattcttga gaataagccg attcagtcat
     7381 ataaggttga atacgtgtat tattttcccc tagtttttct ttcgtatagt actgcgtcaa
     7441 aaattctttt acagtatccg atgacaaaat gctggcttta tcttcagctt gtttgtcctc
     7501 tacaagttta gttgcagcca attcgatttc tttgcgactt tgtttagcag tagaatgttg
     7561 accaatagta tatcccacca tgagaataaa gctagttgcg gctactgctc caacactaat
     7621 taaggcttta gttttgactt tatttaacat cttagacctt ctttctataa aaactaggtc
     7681 aagaataaca aaaagaactt gtaagtttta tcacaagaaa aagtatagtc actaaaactc
     7741 aattacaaga gaaaattaag aaaatcctcc gacaataaaa cgcatagtat caaggttttt
     7801 gtgattcttg atattatgcg tgttctgctt ttcgagactt tttgtacaga ctcataaaac
     7861 ctaatcacaa ttaattatat gaggtttcaa aaagcctttt atacatacct tctttaccac
     7921 ataactcatc atgttttccg ctatctatga ttttaccgtt atccataaca ataatattat
     7981 cgtattcctg agcgttagat agtctatgag ttataaaaat ttgggtaatt cctttatgtt
     8041 ttaaattatc cattattttc ttctctgtta tagtgtccaa ttgaccagta ccttcatcaa
     8101 aaattataat ctctggattt tgcaaaatgg ctcgagctat tgctaagcgt tgcctttgcc
     8161 cacctgataa attgttacca ttatccccaa tactagtata gtatcccata ggcatattat
     8221 taatctctat atctaattca gctaaacttg ctgcagaaat gacatcctcc atagaatggc
     8281 tatgagttaa atctatattg gaaatcacag tgtcgttaaa cattacatca ttttgtaaaa
     8341 caactccgaa actcttccta taactattta aatcaaataa attaatatca ttaccattat
     8401 ataaaatcgt atttttctct acatcataca gccgtagcaa taatttaata agtgtagttt
     8461 ttccgcaacc tgtcctcccc actatagcaa tacgttcacc tttcttaata gttaatgata
     8521 tatcataaat aactttacag gcactactat aagcaaaact caaatttctg aaagtcatca
     8581 tttcaaatgg gggtagttta gaaatagaaa attgattttt ttcttctgga gtataaatga
     8641 tatcaaacac tctatctaaa attgtaaaac aaaattgaaa ttgaaaacag ttttgtacga
     8701 ttagagtaat aggtgaaaga agcaaagata ccaatgataa aaatgacatt aaactcccca
     8761 gagacatcat atgctgctgt acttctagtc ctcccaaaat taaaattagt aagtttggta
     8821 cgagtctata aatagaaata aaagtctgaa aaatatttag ataattttca cgctctacat
     8881 caaatttaag ctcattacta aacatttctt tccacttagt atatgaaaca tctccttttg
     8941 ctgagacttt caaaaataat aaattagaaa aaatttccat caaataacct tgagtcaatt
     9001 ctttagaact gataaagttt gagttctttt cttccaattt ttttaacaaa aaatataaaa
     9061 caataaacaa aaatatagca aaacatgtga ttataagtgt gaaatataat gaaatcattg
     9121 ccatagctat aaaagcgata ataattgtag atagatcaat taacaaactt gatattccac
     9181 ttgaaattat tttctctaaa gaatctaaat tattgattcg agttacaatt tcacctgaag
     9241 atctactatc aaaaaatttc ataggtagag tgaaaatttt gccaacaatt ttatctttta
     9301 atgtaaatat gtatctcttt tcaactgtaa taattaattt agttcgtata aagctaaata
     9361 atgcataaaa tgttattaaa gaaaagattg aaaaaagcat ccctaaacga tacatttctc
     9421 ctttgctaat tacattatca ataataaacc ttgttagcaa aggtaataat aaggtgagac
     9481 tctgtaccaa aattgatatt aaagaaatat aacatagcct tttaatatca attttaccta
     9541 tcttcaatat tttaaaaaaa ttactatgct tctttttttt agtgaatttc ctatttggtg
     9601 agaagaaaat tacaatacca gatatattat tcgcaaagtt tgatatatct tctgtaattc
     9661 tacctcgttc tggatcaatg aatactacac tatgctcatt atgtttttcc accacaatat
     9721 aatgagcatt ttgagttaaa gctatataag gttctacaaa tttgttcccc aaaaattttt
     9781 taatatttaa gatctcagtc gcctttgaat ccaatccaaa ataagaagct atatctttaa
     9841 tctctctaat ggataatcca tcccttgaat tctcaaaatc acagcataat tcatataagt
     9901 ttgcctcatg cccataataa tctaaaatca ttgccatgca tgctaaacca caactggtct
     9961 cagataattg ttgtatgaat tttacctttt tcaatttgaa tcaccaaatt tctagattaa
    10021 ttacagaagg aattgataaa ttattcaaag ttagtaagcc taatcctatt ccagctatcc
    10081 cactcattag acttggagaa ttcttatacg gaagaccgca tttccaattt tctgattcta
    10141 aatcatcaag aatcgtatta agataggagt aaactacatt gtataaatgc tcagaggaca
    10201 ttttcttagc aacataaaat agaatgttta gatttcctaa gtctccatga catagacagt
    10261 ggctttttcc aaaaccatat tttattgttg tatcaattgc tacatccata tcagatttca
    10321 ttgttcttcg aaactctaca ttcaatgtat tatttttata cagttctaat ctacttataa
    10381 gtatacctgg agcaccatgg caccacgaaa cagggatatt ttcaacaata tccttatatt
    10441 tgataccact ttcggtttct ctataatccg accaattaga tttttcagta tcaaacatag
    10501 aattttcaaa aattatacct tgtttaataa tagttttaag ctttttatct tctgggaaat
    10561 atctactaag ttttgacagt gcccacacaa ttcctgagac tccgtgtgca aaacccgcta
    10621 aaggattgga agccatcgtt cctttccatg ctcttccatc ttgcccttca acagtaattt
    10681 ttgtagaatt tttttctaaa tgactaaata aatcatgcgc taatatcaag agttcttcgt
    10741 ctctagtaac ttcaaataca tttagcaaat gtataatcgc accagcagaa cctacaagaa
    10801 catcaaaatt ttcatcatat ctataccctt tttttaaatc atcaataata tcatagatat
    10861 aaacatctag ttcatcagaa ttaaagtgtt caggcatcct tgtcttcagt aacaataata
    10921 catatataat aggggtctct ccagaaaaac ctccaaacag tacctgagag tgagtagcaa
    10981 attgctttct tgaatctaaa taatacttga gagatcggta acattttttc aagtatatga
    11041 gataatcttt tttcttggtc tccaaatata agaataaata gaataacata atacctgata
    11101 taccattata cagatcgcat ccgattggaa ccatattcca atcattcgtt ttctctccca
    11161 gtatgttcat gtctacccag catatatctc ctgaagtacc actatatgaa attttagata
    11221 aatagtcagc aattttttct gttagaggta caattctact tttagtttct tgtatttctt
    11281 tctgatttaa attacgtatc acttttacag atggttttag aggtacaaaa gaatcctgaa
    11341 ctaaattata agaaggatcg taattcaaag ttgtttcaat caaatttaat tgaaattcca
    11401 tatccttctg acaaaagtct tttatttgtt gaattgctaa ttccattcct gaaatattaa
    11461 agaaattttg atatttcgtt agttcagaac ataagaatct atcagatatt tttgtctgaa
    11521 ataatggaat atcacccaat aataatgatt cgaattctga actagctatt ctttgtactt
    11581 ttttatcctc aaaaactatt ttccaaactt ttgaaaataa catttcccta tctagaccac
    11641 tccttaaaaa actaggatga taagatgttt gtattaaatt agaataaaat tgtgtgggcc
    11701 tcattatttg tctagaatac gcattattaa atttttctat ctcaaccaga aactcttcta
    11761 ttgatgaagg atcttttgaa ataatttcat aagcttcttt aaagccagca gaaacgtaat
    11821 ttttatatga attcaaatca acatccttgc ccgattgaat aaaaggctga ttatctttac
    11881 tttgcaatgc ggattgttca taaccaattt tcatttcatc cgtcatacta tgcatgatac
    11941 ttgcacgttc aatcggaatc atctctcctg cgcttgaact tagaccgcta atatccaccc
    12001 cagagttccc atctttaccc caaactatat taggtaaaat acctactctt ttcacagatt
    12061 tttctaataa agagaatatt agtttatctg ccgtttcgta ttcctttctg tattccgttg
    12121 tattatgaaa taatgtttca atatcgacaa gaactggtct attaccctta gctatgatat
    12181 tttcaaaatg aatatcgttt cccctcatag caaataataa gaataacaag tatcctagat
    12241 gtgtataaaa ctgaataaaa tcagattcat atgtgcatgg taagtgttct atgtactcta
    12301 cccatccata atttccacga ttcaaaatat ttgttacata tagattttta ttgaatttca
    12361 ggttgtacca gctaagcaag ttttgaaact tcacatccaa tattaaatct cttggtttat
    12421 atactaactt atttgttcca aaccaaagga gatatactga ttttccatga ttatgaaaat
    12481 ctgacacacc agattcaatc tttgttaact ccccattgat agaaaaatgt tcctgtaata
    12541 atgctttatc ttcttttagg tttgttaaaa attctacatt attagtaacc caattttgaa
    12601 tattttcaat aattaatcga aacataacag gatattcttt taatatatcc caaaaatggt
    12661 ctgataagta tatttctgaa aaatatttaa atcttttttc tccagtttca ccttttaaca
    12721 tattttgttc tttcagaact tgtaattcta atatcaatgt tctgtaagaa atattcaaaa
    12781 tttgttggaa taacgcaatt aataaactat tcaagacgtc tctagtgact ttcaaattct
    12841 gactactcaa attatcttca agtttatagg cggcaaattt taaaaatggt atgacaaaat
    12901 tactgaaaat aggttttcgt tttccctcac tgtcaactat ataaaactct ggtaatgtat
    12961 aatcatttct cttaaaaaag aactctataa attcgtccat atgtgaaaat gaatctatat
    13021 ctttcacatc atatgtatgt tcttccaaaa aaatatctaa atcatgttta gaaaaatcat
    13081 ttttttcttg taaatatttc caaaattcat tagaaccttc tccaataaaa ttatcccaat
    13141 actcttttct ttttcttgat ttcaaaccat cccctaaatc atgactagaa atttttcttt
    13201 cagagaaata agaagcatct ttaaaatctg ttatgtttaa ttttcgattc attttcaact
    13261 cctaaatata aaataacagg tgacatccta cttttaggtg tcacctatcc caaagattca
    13321 atagaattaa tctattaaca acaaatgaat gttaagaaag gacactctgt ggtgatagta
    13381 caaccacgac cacaagaatg ctctcctgaa taacatgcgc aataagatct ggctgttccg
    13441 ccagccatag cttgatccat ctcgctatcg ctaagttcac gcaagatatc cccagctgga
    13501 ttaccttctg tacttagtga ttcgtaaata ggttttttcc aatcagacat aattgttgaa
    13561 tccctttcta gttactgatt tctcttatta aatatagtga cacctcaaat ctttgggatt
    13621 aaaaattcaa aagagatacc agtagcaaat atttaaatcc gctgtaatta taactctgaa
    13681 agttatgatt acagtcattt ataagcaaaa ataatgttca tcatgcgttt atctgccaac
    13741 aaataaagga gacatgccac caaggtaacc aaccaaatgg catatacaga aactgttaaa
    13801 gccgtaaatt gctccatgat gattagtagt aaatttgcca gataataccg cccaacaacc
    13861 gttgttaaag caaacaaacc tgcaaatgac aataaaaagg caagtggtag ggcaaggata
    13921 agttccttcc gatattttcc taagaagagg acaataatac cagcagacag tgtataagca
    13981 aaagcaattg ctccataaac aactccccaa gataacattg caagactaga gaaagcaaaa
    14041 tcaccatcca ttaactctag gaccagcata gccaaaaaag tgaattcact gactagtaga
    14101 ttaatcaaca aagcaagcat aaatttcgct tggagtaatt gtttcaaatc gacaggaatc
    14161 agtctgagat ttgaaatcgt tttagacact tgttctattc ttatcaaatc cactaaaatc
    14221 atgctcgcaa aagggaggag aaaatagtag ttcaaaaaga agaaaccatt ttctacatac
    14281 cagccattca cactaccgta cgaatgccct tgataaatct gatgaccaat cataaactcc
    14341 aacaaaaaga gcaggatggc tacaaaggga atcatataca gtatctttcg ccttcttagt
    14401 ttagtaaatt ctagcatcaa catttattca tccacctttc ttaaccaaga tttaatggac
    14461 aagaaagaca aaacaagtaa agataaacct agtacaacaa tcgataagat agctggctgt
    14521 tgaagcacca ctccttctct gtttccttcc cagattaaac tgttagcact tgttactgga
    14581 ctgatatttg gactcgtcct tgctaaaaaa aatgacacta aaacatacat gacaccgacc
    14641 aaattcccaa ctatctcctt gcctctgact tttatcatga ccaaagcaac taaaggaaat
    14701 actcccatgg gaattaagat accactactc atacaaagat agaagaatct taataataaa
    14761 gacaaactga ctgtcgaaga aaagcgggat agtagtgcga ataaggaaac cgaaatatag
    14821 gtgaataaca tgatacacag agcgttgatt tctatataca aaatcttagc ccagaatgtc
    14881 ttcattagat ttgctgaagc gagtttcaag ttgttcatga tgcgatagcg atattctaaa
    14941 ccaaatgcct gtattgtata ggaaacacaa tacaaaggga gaatcaaaaa gtttaaataa
    15001 gacaaagaga atttatagac aaagggaaag gagtcaaaca agcctctcgc atcatttaca
    15061 taataacaga tgagagctag gtagagggaa acaacaccat atacgacaaa attcagtttt
    15121 tgatgccttt gtttgagaaa ttcaatcttc actaaatcaa gcaattccct cacctcctgt
    15181 tatccgctta aagtaatcct ctaaactttc attgttttta taagaatatt cttttagaac
    15241 tattccgttg tcttttaagg agttagatac gactgcaatg tcaaaagtag gtgattctcc
    15301 ctgaagttca agttctatat ccgaaagaat actaatctgt tcttgcagat ttatcctgca
    15361 aagcacttcc ttagcttgag gagcatccga aacaattagg tggattttcc ttttatctgc
    15421 accatctatt aattccttca tagtcttttc agccataagg tgggcatcat gcagtatccc
    15481 aactctatct acaagctttt caagttctga aataatgtgg ctggatatta aaatcgaaat
    15541 gccatgattg gtactgagtt cctttagata acggcgcatt tcaaggatac caataggatc
    15601 taaaccattt gttggttcat ctaatatcag aattttcggc tggtgcataa tagcgttagc
    15661 aattgctaac ctttgcttca ttcccagaga atactgcttg aatagttttt tattttcccc
    15721 atctaatcct actacttgta aagcttgctc cacctgtttt agcgaaatcc ctctcaatct
    15781 tgcaaaaata gagagatttt caggtcccgt taaattagga taaaaagaag cactgtccaa
    15841 taccacaccg atttgagata gcaaatcctt agaaaattcg cctaacagtt tttcagatag
    15901 aatattcact tcaccactat ccatagctgt caagcctaaa atagccttga taaaggttgt
    15961 ctttccagta ccatttcttc ctagtaagcc atagatttct ccctgtctta atgtaaaatc
    16021 tatcctatct aagacaattt tcccatcata ggattttgat aaattaaatg tctgtattac
    16081 tggatttctc atttttctcc tccgaacatt cgtacaccca cataagagat ataataaagt
    16141 agttcctgta taactagtta gttatatgag agggtaatag ggtatatcaa acttacaagc
    16201 tccctttaag cccttcaatc tgtggcatga tccattgtat aaatgttact tcacaaaaag
    16261 tttaacaaat caatccgcca gtcccagatc aacttcatta gttgttacag cttgttgtat
    16321 aattctcgat tcccaggtat attgtgattg atttacaggt tccttgaaaa agaaaccgct
    16381 tccaaacaat cctaaaaagg acaacataaa aatgatttta cgaaactttg ctaaaatact
    16441 catattaacc acctttttct tatctttaca cttgtaagtg tactacttta aatattattt
    16501 gtcaataaaa aataattctt tttttcattt tttttttgtt ttattttttt atgactattt
    16561 ttgtattaga aagttgaaaa atagagatta aaagtatata attaatctta aatttattta
    16621 aagagggtta gagatgacca tattatctga taaactaaaa gccaagagaa aagaaaaagg
    16681 attctcacaa aaaacacttt ccgaaggaat ttgtgagcaa agccaaataa gcaaaataga
    16741 acgtggcaac tatatgcctg ccgctgattt actctataaa cttgcaaatc ggcttcaagt
    16801 tcccttagat tattttttcg atgaacagat tgaaatgact tccaatataa caccgtttaa
    16861 gaaattagca gaaaaattac ttgaagatcg taattacgag gatttagaat acctcttaaa
    16921 cttagaaaaa gaaaagtctc agtatctatc tactgaggat gaattttatc ttctatggat
    16981 tcaatcgatt atccttttct acttacatag ttccaaagat gaagctatcg ccagtctaga
    17041 aaacgctttg ccaaagcttt cggtcagctc atctgtgtat cttaaactcc tcaatacttt
    17101 atctaatttt tatttttctg tagggcgtga tgcagaatac gaagaaaata actcacttct
    17161 tatcagtttg tatcaggaaa aagatttaaa ccaccaagag tatttatttg gttatattcg
    17221 agttaaacat aatttcgcct attatttaca ctctaaaggg aaggaattag aagccgtcca
    17281 agaagcctta gaaaccattg acttttgtaa acaaaaagag accagctatc agctggctcc
    17341 tcttttaact atcgttgcga atgccggaaa agatttttta aagcacgatg aaattcttga
    17401 ctattattta caggctcgtg atatctgtaa aatatacgaa cacaagctca tgatggctaa
    17461 aattgaccat tttttgaaag ataaggatag gtgacttcga ttgtaataag ttataattac
    17521 taattaatta gaaacataaa agtggagaga aactaatgtc gttttctcca cttttgttaa
    17581 tatcccctct tccacttgta tcctgcccag catgctaaag caagtaaaac taaattaaag
    17641 atgataaaga aagtcgtaaa accaaataat ccattttgag ctaaatctgc cgtgtaaagt
    17701 tcagtttctg taaagagaag ataaattcca tagacctcca cgaaaataag gaaactgaca
    17761 aaaccaatca agaaaagtcc actggcaata agaaagagtc tccataaaag aatgagaatt
    17821 cctcctactg ctaaaaaaat tactgggata aggagtaaat cattcatgac tttctccttt
    17881 ctagtcaatc aattgacgat aatgggtggc aagagaggaa tcaaactctt ctagtttttg
    17941 aaccaattcc agatagtcct ttttttcata ttcttcaaag tccacacctc gatgattctg
    18001 aagagcgatt tccaattggc tagtaagttc tcgtttggaa aagctgtaat cccctgtcac
    18061 ttcctcataa tgttccttta actccttgta ggcttggtat tcttcaggtg tttgaaatcc
    18121 ctgtaccaaa gcctcttcta attgataata ggtatcttcc atcataatcg ttacctcgtt
    18181 tctttctatc tttattttac cgcgcttttc ttttcttgtc cgctatttgt atctattttt
    18241 taatctaatt caaaagaaag ttgttcttgc ttttcttttc ctttttcgtg gaattgtctt
    18301 aaggcctgat caatagtatc taaatccgtt tctgtttcaa tcaatggcgc gagtacatcg
    18361 tattcggcct ttttagtttg ataatcctct tcctttggaa aatttttctc aatttcaact
    18421 ttagcagtat tccatttatc ctttaattca tccaataagt tctgagtttt cacttggtcc
    18481 tctttaatgt gatcaatcgt atgctgaagc ctttgaattg tccccaaagg agaatataaa
    18541 tctaaactga cagaatactg attctctcct acaattttaa cagagaaggt ttcaggaaga
    18601 ggttgatttg ttggaagact aagcatttta atgtcaaatc ctcgatagct tgctagggta
    18661 cgaaattctt tgctgtcagc ttgattatga cgaataagac ggtgtaggga ttcccctgct
    18721 tcagctcgtt gatcaaaaga ttgcttacct accctcatag aaaatgcctg gtctttcgat
    18781 atttcagact gttgaatatc gccttcatac ttgcttaatc gtttctcaag aatgggcata
    18841 ttttcttcac agtaagagat tgtatgacga tagtgatcct tgctgcgttg aaaggcgcgt
    18901 ctttgatttt ctaatagagt tagatcattc tctagttcca tcttatattt gagataagga
    18961 ttacctgttg ctagtgcctt aaaatcagaa gctgtcatag tctgttcatc aatgtcttct
    19021 gcagcacgaa tcggctcctt agaagtcata atctgcttaa tataacggag tttgttctcc
    19081 tgagttgccc atagataatt atcaaatgaa cctttggtaa tgtagtggta aatatccact
    19141 tccttatttt catttccctg tcggataata cgtccattgc gttgtaggct aagtacccag
    19201 cgccttacca tattactacg tcaggtttcc aaatactcgc ccccgaaccg tacgtacacc
    19261 tttcaatgta tacggctctc cgtttataaa ctcaatctaa cttgccatga tgtaatttct
    19321 tatggcaatc tttacacagt gctattgttt tccgttgtct agaaatcatc aaacgttccc
    19381 aaaaagtctt tccctttaaa tcctttagtt ttctcacatg atggatttct agggaactgt
    19441 cggtcgcttg acaatactca caacggcttg cttttaatct atcaattaaa tttgttcgac
    19501 taaaatattt cgccgtattt ggcaaattat cattttcaag gaaagatttc ttttgacgtt
    19561 taaatcctcc gttatataaa taacgggtca ttgtatcccc tttacgtcca atatactgta
    19621 cactaaattg accatccttt ttatatttac ggatgatgtg ggatttagtc gtacgatatt
    19681 tagtcgcata agttttatac atgctatatt ccatgatgta cttaaagcga tgaaggatag
    19741 agctgttatt agcgatacaa taatagttat aaaaacctct tatttctgca ttgtagcgtt
    19801 ctaaaatctc taaatcatcg caatctttca tgaaataacg ggccgttggt ttccaaactt
    19861 cgtagcctct atgataagtc attttcatag ctccgtaaga cagtaatctg tctcgaatcg
    19921 tttcaataga aacctctagg actaatctac ctgtataatt tcttaccaat cgtcctgccg
    19981 aatcacgctt agctaaattc gattggcgaa tatacagatg atatcccaga aacttagctt
    20041 tatctctcgc attggtaatc aaggttttct ccacagagag ttccaatttg agaaccgctt
    20101 ccaaatagtc cttaatatct gctttaatgc gatgagcgtc ctctttactg ccaatcacac
    20161 cgcagataaa atcatctgcg tatcgggtat aggttagacg tttaaaacta ctatccatag
    20221 gatcactatg aggaattaac actctttcct tttccaattg acgaatacgc tggataactt
    20281 cttgtcgttg attttccgtt gaaacacatt ctaatgctct tcttgctttt cccaacgcta
    20341 tctcattttg gcgatattct ggggtacgtt tccggtattt cccttggcag aagttcttca
    20401 cataatccgt catatattta tcaaacttat ccaaatagat attggctaga atgggactga
    20461 ttatccctcc ttgtggagtt cctgagtagg ttttgtagaa tttccaatct tccacgtatc
    20521 ccgcattgag gaatttacga atcaagcgta agaaccgctc atcagtaatt ctttctcgga
    20581 gaatgtgaat catcacatca tgattgatat tatcaaagaa tgacttgata tctccttcaa
    20641 taaaccattt tgttccagtg taggtcttct gaatctgagt aagtgctgta tggcaacttt
    20701 tattcggacg aaaaccatgg gaagagggtt caaattgtcc ctcgtagata gcttccaaaa
    20761 tcattttaat aacctgttgt aagagcttat catcaaatga tggaatacct agtggacgta
    20821 gcttcccatt ctttttagga atataggttc gtcttgatgg gtgtggctga taggattcat
    20881 ctttcaggga atcaatcaat tggtcaattc tagctatact cataccatca atcgtcaact
    20941 cgtctactcc aggtgtcaag tgtcctgggt tagcgtaaat cgtttgatag gcaactaagt
    21001 acatttcttt gttataaagc aaacgataca gtcgctcaaa ttgatagttt ttatctttac
    21061 tgtgttttgt tagattgttt aacacatttt gaggatttct catggtgtct cacacacctt
    21121 cctttccata atgttaatgt tataaactgt tccccttcgc catgtacgtg ccattaacac
    21181 gctcggacta ctatgggaac tccgttacct tatcaaatat tcataaacct tatgtttaat
    21241 agcttttaca agcgttttga cttaggtaat ctccgtttag ctggtatagt aacatagctt
    21301 gataatttca tcggatagga cgttcatctg ttttcattta ctatgaatac gctatggaat
    21361 ccctttgctt cactatcttc aacagtgata atgaagttcc atagtatgag gattttagtt
    21421 atcttacctc acagtcccga cacagaccgt ttagactatc cttcaatcag tttagatttt
    21481 atccttataa ttatctcaat aacatctgtt acattatcat ctcctcattc agtcgtgatg
    21541 tgataactca tcaacttatg agtttcccaa cgtgctttgt tccctgatgc ttggtttccc
    21601 tcacaggtca gttgggtgat gataggcatt aaggtcacgc ctactacttt gccaagagta
    21661 gatttactat accgccttta cggacgcacg ctgaatgtca cttggtctcc acggtacatc
    21721 cagatgatga actgctttca tcttgctctg aacatttaaa cctgttcctc ctttttcagt
    21781 tgaggcaagg agaatccgca cctctcctgc attgaccttt cgagacaaac tattcttctt
    21841 ttcatcacta ttggcatcat gtacaaaggc aatttcttta ctagggattc ctctatcaac
    21901 taataaagcc ttaatctcag aataaacatc aaagccatta tcttttttct taggtgtgcc
    21961 aatatctgaa aaaatcatct gagtagcctt attttccatt ccctcacgat aaattctttc
    22021 aacattatcc actacctgaa gcagtttatg attgtctgct agactataac tagagtccaa
    22081 taaacgcata tcaatagcta gttttcgtgc ctcacccgta atttttaaca tgttatcctg
    22141 gctcggatca actgttccac atttgaccat atctgacctc ataactaatt cttctaaata
    22201 gagtttctgg ttttcagtta actcactctc aatagggata atatgagctt ctggaacagg
    22261 taaatccaac atatcttgtg tttgaatgtc ggctgtttct ttatagattt tcatcaactc
    22321 aggtagattg acaaactttt taaatcgttt cttaggttgg tacttatccc ctgtaggagc
    22381 taattccata gagttttgaa tttctccaaa agcacctacc caagagtcaa aataatcaac
    22441 ttgatagcgt tttaagatat ctggttgaat atagttcatc atagtataca actcactaat
    22501 agaattggaa acaggtgttc ctgtcgcaaa gacaatattt ttaaaatcat gttcttcctg
    22561 aatctgtcga accttcatct ccatatccac gttcttctta gaggttgtat tggtaatacc
    22621 tgctacattc ccaagtccag taattggacg aatattttta aagtgatgtg cttcatccac
    22681 aaagagaaaa tcaattccta agttctcaaa atcaataaaa ctatcacgat taaagcgttg
    22741 cagttcttcc aattgtttct ctagaccact tattgattgt tctgcttctt taacggtata
    22801 cttattttca gaatgtgttt taatctctcg tagttcattg agtttatcct ctatatagtt
    22861 catctgtctt tccttactga cagggatttt ttcaaattga gaatccccaa tgacaatagc
    22921 atcgtaatct cctgtaataa tacgtgatac aaattgtttt cttctcgcct tcacaaaatc
    22981 tttcttagtg gtcacaaaga cttttttagt agggaaaaat ttcatgattt cttggccaaa
    23041 ttgagcagac aaactagagg gcaccacata taatggctta tgaaccatcc ccaactcctt
    23101 taatttaaac ccagcaccaa gcatggtcaa ggtctttcct gaacctacct catgagctaa
    23161 tagggctctt ttttcttcta cgattctttg aatggcattt tcttggtgag gacgaagact
    23221 gatgttttgt gctaagccat caatgactag at
//
