LOCUS       NC_011900              20876 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Streptococcus pneumoniae ATCC 700669, complete sequence.
ACCESSION   NC_011900
VERSION     NC_011900.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptococcus pneumoniae ATCC 700669
  ORGANISM  Streptococcus pneumoniae ATCC 700669
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Croucher,N.J., Walker,D., Romero,P., Lennard,N., Paterson,G.K.,
            Bason,N.C., Mitchell,A.M., Quail,M.A., Andrew,P.W., Parkhill,J.,
            Bentley,S.D. and Mitchell,T.J.
  TITLE     Role of conjugative elements in the evolution of the
            multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F
            ST81
  JOURNAL   J Bacteriol 191 (5), 1480-1489 (2009)
   PUBMED   19114491
REFERENCE   2  (bases 1 to 2221315)
  AUTHORS   Croucher,N.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-SEP-2008) Croucher N.J., Pathogen Genomics, Wellcome
            Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
            Cambridge, Cambridgeshire, CB10 1SA, UNITED KINGDOM
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 00:47:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,268
            CDSs (total)                      :: 2,195
            Genes (coding)                    :: 2,039
            CDSs (with protein)               :: 2,039
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 156
            CDSs (without protein)            :: 156
            Pseudo Genes (ambiguous residues) :: 0 of 156
            Pseudo Genes (frameshifted)       :: 82 of 156
            Pseudo Genes (incomplete)         :: 70 of 156
            Pseudo Genes (internal stop)      :: 58 of 156
            Pseudo Genes (multiple problems)  :: 45 of 156
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:23:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1069689
            Orig. end                         :: 1090565
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FM211187.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="4"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20876
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10876](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10876)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    134..147
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.2"
                     /tool="antismash"
     gene            complement(781..1296)
                     /gene="lacB"
                     /locus_tag="SPN23F_RS05540"
                     /old_locus_tag="SPN23F10910"
                     /old_locus_tag="SPN23F_10910"
     CDS             complement(781..1296)
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /locus_tag="SPN23F_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F10910"
                     /old_locus_tag="SPN23F_10910"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_001216910.1"
                     /transl_table=11
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPIF
                     GKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNANVI
                     GFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHLESHNAQQTDANFFTEFLEK
                     WDRGEYHD"
     gene            complement(1327..1752)
                     /gene="lacA"
                     /locus_tag="SPN23F_RS05545"
                     /old_locus_tag="SPN23F10920"
                     /old_locus_tag="SPN23F_10920"
     CDS             complement(1327..1752)
                     /EC_number="5.3.1.26"
                     /GO_function="GO:0050044 - galactose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /locus_tag="SPN23F_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F10920"
                     /old_locus_tag="SPN23F_10920"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_000029274.1"
                     /transl_table=11
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLA
                     VAAEVNKEEQNLGIVIDAYGAGSFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMG
                     AQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     misc_feature    complement(1905..1918)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.35"
                     /tool="antismash"
     gene            complement(1910..>2407)
                     /locus_tag="SPN23F_RS05550"
                     /old_locus_tag="SPN23F10930"
                     /old_locus_tag="SPN23F_10930"
                     /pseudo=""
     CDS             complement(1910..>2407)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234238.1"
                     /locus_tag="SPN23F_RS05550"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F10930"
                     /old_locus_tag="SPN23F_10930"
                     /product="aldose 1-epimerase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="NKETSKVRPYFIGGHPGFNCLLLDDEVYEDYYLEFEKEEICSVPR
                     PFPETGMLDFQDRSPWLEGQKEIDLSYDLFSTDAVTLDELQSRTIALRSLKHDKGLKVH
                     FAEFPNLIIWSTLNKGPFITFEPWSGLSTFLEEGDHLEDKKNVCLLEANQVEELGFEIE
                     VL"
     gene            complement(2423..3227)
                     /locus_tag="SPN23F_RS12290"
                     /old_locus_tag="SPN23F10940"
                     /pseudo=""
     CDS             complement(2423..3227)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="SPN23F_RS12290"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F10940"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNDEASKQLTDARFKRFVGVQRTTFEEMLAVLKTAYQLKHAKGGR
                     KPKLSLEDLLMATLQYVREYRTYEQIAADFGIHESNFIRRSQWVEVTLVQSGVTISRTP
                     LSSEDTVMIDATEVQINRPKKRISE"
     gene            complement(3235..3536)
                     /locus_tag="SPN23F_RS05565"
                     /old_locus_tag="SPN23F10970"
                     /old_locus_tag="SPN23F_10970"
                     /pseudo=""
     CDS             complement(3235..3536)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /locus_tag="SPN23F_RS05565"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F10970"
                     /old_locus_tag="SPN23F_10970"
                     /product="PTS sugar transporter subunit IIB"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIKILAACGEVLTRVTKLKVL"
     gene            complement(3574..4050)
                     /locus_tag="SPN23F_RS05570"
                     /old_locus_tag="SPN23F10980"
                     /old_locus_tag="SPN23F_10980"
     CDS             complement(3574..4050)
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /locus_tag="SPN23F_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F10980"
                     /old_locus_tag="SPN23F_10980"
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="WP_000242183.1"
                     /transl_table=11
                     /translation="MVLDYFFDKNLVFCLEADNQEQLFDQVASLLEEREIVTPTYREAL
                     ITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDKEV
                     EVSLLFFIINNSSSSQTNILAQLMDFFTGNGHLEDLSKISEPEKLYAYIAEAIA"
     gene            4230..4382
                     /locus_tag="SPN23F_RS13900"
     CDS             4230..4382
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SPN23F_RS13900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_001814238.1"
                     /transl_table=11
                     /translation="MKIKEQTRKLAAGYSKHNFEVVDETDEVSNHTYSKATLTWFEEIF
                     EEYKN"
     gene            complement(4463..6286)
                     /gene="lepA"
                     /locus_tag="SPN23F_RS05580"
                     /old_locus_tag="SPN23F11000"
                     /old_locus_tag="SPN23F_11000"
     CDS             complement(4463..6286)
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /locus_tag="SPN23F_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11000"
                     /old_locus_tag="SPN23F_11000"
                     /product="translation elongation factor 4"
                     /protein_id="WP_001047216.1"
                     /transl_table=11
                     /translation="MNLEELKKRQGKIRNFSIIAHIDHGKSTLADRILEKTETVSSREM
                     QAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAAC
                     EGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVIGLD
                     ASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQVRVM
                     DGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQDTRVGD
                     TVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETS
                     QALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMDVSNPSEF
                     PDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLA
                     EIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFIVHKDFAYER
                     GKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGGDVSRKRKLLE
                     KQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(6365..7093)
                     /locus_tag="SPN23F_RS05585"
                     /old_locus_tag="SPN23F11010"
                     /old_locus_tag="SPN23F_11010"
     CDS             complement(6365..7093)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /locus_tag="SPN23F_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11010"
                     /old_locus_tag="SPN23F_11010"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_000133341.1"
                     /transl_table=11
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHR
                     VLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLDAP
                     VDGVEDAKRVAAEASDLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLR
                     KPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVF
                     TDQGMTEHHFIENDGFVAED"
     gene            complement(7095..8762)
                     /gene="recN"
                     /locus_tag="SPN23F_RS05590"
                     /old_locus_tag="SPN23F11020"
                     /old_locus_tag="SPN23F_11020"
     CDS             complement(7095..8762)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /locus_tag="SPN23F_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11020"
                     /old_locus_tag="SPN23F_11020"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_000923593.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNMM
                     LGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGRSI
                     SRVNGQMVNLSVLRTIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKETYQT
                     SFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLALNQERDKLLNH
                     KNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYYVLEDI
                     SKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEYNLLTGN
                     NLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKAQFQVRFS
                     KGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKEGKTSIVFD
                     EVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKISNDHSTVSTV
                     RLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            complement(8769..9200)
                     /locus_tag="SPN23F_RS05595"
                     /old_locus_tag="SPN23F11030"
                     /old_locus_tag="SPN23F_11030"
     CDS             complement(8769..9200)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /locus_tag="SPN23F_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11030"
                     /old_locus_tag="SPN23F_11030"
                     /product="arginine repressor"
                     /protein_id="WP_001034415.1"
                     /transl_table=11
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRDI
                     KELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVKAQ
                     LIETFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            complement(9193..10008)
                     /locus_tag="SPN23F_RS05600"
                     /old_locus_tag="SPN23F11040"
                     /old_locus_tag="SPN23F_11040"
     CDS             complement(9193..10008)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /locus_tag="SPN23F_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11040"
                     /old_locus_tag="SPN23F_11040"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_001041072.1"
                     /transl_table=11
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPGE
                     KIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQNS
                     AKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISLSLI
                     LPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKIHQNVLESVTAMAVEAGFSV
                     LGLDFSPIQGGHGNIEFLAYLKKEKSASNQIFAEIKEAVERAHSQFKNE"
     gene            complement(10001..10876)
                     /locus_tag="SPN23F_RS05605"
                     /old_locus_tag="SPN23F11050"
                     /old_locus_tag="SPN23F_11050"
     CDS             complement(10001..10876)
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /locus_tag="SPN23F_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11050"
                     /old_locus_tag="SPN23F_11050"
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_000743813.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.6e-55, bitscore:
                     185.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPF
                     LLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEA
                     MAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLS
                     LEELQIIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTA
                     SFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQLPFETESIV
                     SVVESLRING"
     gene            complement(10873..11085)
                     /locus_tag="SPN23F_RS05610"
                     /old_locus_tag="SPN23F11060"
                     /old_locus_tag="SPN23F_11060"
     CDS             complement(10873..11085)
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /locus_tag="SPN23F_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11060"
                     /old_locus_tag="SPN23F_11060"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_000043230.1"
                     /transl_table=11
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKEL
                     QATLDKAEKTLVKVMQEDGTESDFE"
     gene            complement(11063..12403)
                     /gene="xseA"
                     /locus_tag="SPN23F_RS05615"
                     /old_locus_tag="SPN23F11070"
                     /old_locus_tag="SPN23F_11070"
     CDS             complement(11063..12403)
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /locus_tag="SPN23F_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11070"
                     /old_locus_tag="SPN23F_11070"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_000417468.1"
                     /transl_table=11
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDGVG
                     ALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGV
                     DILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIF
                     ESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLTHLQNQEKRMATA
                     VRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQA
                     RTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIV
                     ARGYAIVKKEESIVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            complement(12531..13169)
                     /gene="udk"
                     /locus_tag="SPN23F_RS05620"
                     /old_locus_tag="SPN23F11080"
                     /old_locus_tag="SPN23F_11080"
     CDS             complement(12531..13169)
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /locus_tag="SPN23F_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11080"
                     /old_locus_tag="SPN23F_11080"
                     /product="uridine kinase"
                     /protein_id="WP_001181378.1"
                     /transl_table=11
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKD
                     QSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEP
                     QDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLG
                     VVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     misc_feature    13209..13223
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.39"
                     /tool="antismash"
     gene            complement(13277..13579)
                     /locus_tag="SPN23F_RS05625"
                     /old_locus_tag="SPN23F11090"
                     /old_locus_tag="SPN23F_11090"
     CDS             complement(13277..13579)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /locus_tag="SPN23F_RS05625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11090"
                     /old_locus_tag="SPN23F_11090"
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_000985093.1"
                     /transl_table=11
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQTV
                     MANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            complement(13820..14698)
                     /gene="truB"
                     /locus_tag="SPN23F_RS05635"
                     /old_locus_tag="SPN23F11100"
                     /old_locus_tag="SPN23F_11100"
     CDS             complement(13820..14698)
                     /EC_number="5.4.99.25"
                     /GO_function="GO:0004730 - pseudouridylate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /locus_tag="SPN23F_RS05635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11100"
                     /old_locus_tag="SPN23F_11100"
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="WP_001013238.1"
                     /transl_table=11
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGVL
                     PIAVGKATRMVEFMQDEGKIYEGEIILGYSTTTEDASGEVVAKTPVLSSLDEKLVDEAI
                     ASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDGQLA
                     RFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALTLEEIAEKVEA
                     GQLDFLHPLEIGTGDLVKVFLTPEDATEVRFGRFIELDQTDKELAAFEDDKLLAILEKR
                     GNLYKPRKVFS"
     gene            complement(14708..15982)
                     /locus_tag="SPN23F_RS05640"
                     /old_locus_tag="SPN23F11110"
                     /old_locus_tag="SPN23F_11110"
     CDS             complement(14708..15982)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /locus_tag="SPN23F_RS05640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11110"
                     /old_locus_tag="SPN23F_11110"
                     /product="DUF2130 domain-containing protein"
                     /protein_id="WP_001002634.1"
                     /transl_table=11
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMRQELA
                     LAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHQALLAKDKEVQA
                     LENQLATLRLEHENQLQKTLSDLEKERNQVKNQLLLQEKENELSLASVKQNYEAQLKAA
                     SEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGSKGDF
                     IFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLVTMLEA
                     DNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVREQNIDIM
                     HFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQLRLANNKL
                     EDVSVKKLTRKNPTMKAKFEALKGE"
     gene            complement(16078..17337)
                     /locus_tag="SPN23F_RS05645"
                     /old_locus_tag="SPN23F11120"
                     /old_locus_tag="SPN23F_11120"
                     /pseudo=""
     CDS             complement(16078..17337)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /locus_tag="SPN23F_RS05645"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11120"
                     /old_locus_tag="SPN23F_11120"
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRDFKFETLQLHAGQVVTPATKSRAVPIYQTTSFVFDDT"
     gene            complement(17485..18282)
                     /locus_tag="SPN23F_RS05650"
                     /old_locus_tag="SPN23F11140"
                     /old_locus_tag="SPN23F_11140"
     CDS             complement(17485..18282)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015499 - formate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015724 - formate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /locus_tag="SPN23F_RS05650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11140"
                     /old_locus_tag="SPN23F_11140"
                     /product="formate/nitrite transporter family protein"
                     /protein_id="WP_000254802.1"
                     /transl_table=11
                     /translation="MVSSEFISKIEFACNKKESLYSQSKFKYAIRSMFAGAFLTFSTAA
                     GAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSLLKKISWRK
                     TAEILLYCTLFNLIGALIAGWGFAHSAAYANLTHDSFISGVVEMKLGRSNELVLLEAIL
                     ANIFVNIAILSFVLVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVAADSI
                     ANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     misc_feature    complement(18435..18449)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.19"
                     /tool="antismash"
     gene            complement(18526..19269)
                     /gene="srtA"
                     /locus_tag="SPN23F_RS05655"
                     /old_locus_tag="SPN23F11150"
                     /old_locus_tag="SPN23F_11150"
     CDS             complement(18526..19269)
                     /codon_start=1
                     /gene="srtA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /locus_tag="SPN23F_RS05655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F11150"
                     /old_locus_tag="SPN23F_11150"
                     /product="sortase SrtA"
                     /protein_id="WP_000078846.1"
                     /transl_table=11
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVWN
                     TNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPELE
                     MNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNAKNG
                     MKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIVKGDL
                     KETKDYSQTSDEILTAFNQPYKQFY"
ORIGIN
        1 gccacagtag agtctccaga tccaacagga tttaccacct gaattctagg aatatctacc
       61 ttgtagaaag tgtcaccatg tttggcaaaa gtaccgttgg caccaagtga aacgataatc
      121 cattcaatcc ctgcaaacaa aggttcttga agtacttctt ttaattcatc caaatcctca
      181 gaaacttctc ttccaagaag ctgagacaat tcttcattat ttggtttgat gactgttggt
      241 ttatggggtg attcaagaac agcctgaagt gctgcacctg agcagtccaa gactacaggc
      301 ttgccagctt gattagcaag ttctaccaag ctcgcatagt aatcaactgg aaggccagct
      361 ggcagactac ctgagatggc cactacttca actgactcca agagtttttt gaaatgttcc
      421 aaaaagtctt gaccttcctg ttccaatact tcaggacctt tttcaagaac ttctgtttgg
      481 ttgtctccgt ggagaatagc gatacagtta cgagtttctc cctgaattga gaagaaatct
      541 ttctttactt gattatcgat atgttcaacc aaaaactcac caagtttgcc acccactaaa
      601 ccagtagcaa gaacagaatc gccaaattct gaaagtactc gggtaacatt gagtccctta
      661 ccaccagccg ttttggttac atccaccaca cgattgacag tatcaatctt caactcatcc
      721 aagggatagg aaatatcaat ggatgggttc attgtgactg ttaaaatcat aggtcacctc
      781 ttagtcgtgg tattctccgc gatcccattt ttcaaggaat tctgtaaaga agtttgcgtc
      841 tgtttgttga gcattgtgac tttcaaggtg ttcaattttc gcaatcaatt tcttgttttc
      901 ttcagatggt ttgtattcag catgaatgaa agcttcgatg atatcacaca taagcaattc
      961 accagtaatc ttaccaccaa agccgataac gttagcgttc aattgttctt tagcataaag
     1021 ggctgttgtc atatcacgaa ccaaggcaga acgaacacct ggaactttat ttacagcgtt
     1081 gttgatacca acaccagtac cacagataca taccccaaga tcagcttggc cgctagttac
     1141 agcttcccct acttttttac caaagattgg gtagtgagtc cgtgtatggt catatgtacc
     1201 aaagtcaatg acttcatatc cttttgattt caaaaattct gaaaccgcca ttttttcatc
     1261 tgttacgatg tggtcgcatc caattgcaat tctcattttt aacttacctt tcttactgta
     1321 atctaattag cccattttgt tcaacatgtc gacccggatt tgatgacgtc caccatcgta
     1381 tttaccgtta acaaatcctt tagcgatgtt tttagccaat tcatcaccaa caagttgtgc
     1441 acccatagtg atcatacgtg agttgttgtg gccacgagtc atataagctg aacgttcgtc
     1501 agatacttct gcagcaacca ttcctttgat cttagttgca accataaatg aaccagctcc
     1561 ataagcatca atcacgatac caaggttttg ttcttctttg tttacttctg cagcaacagc
     1621 gagagtcaca tcaacaaagt cttgaccttc agctgtaaca tccacaaggt ggaagttttc
     1681 tttttctaag aagtctttca caacttcttt caatctcaaa cctgcagcat ctgcaccgat
     1741 aacaatagac atattgtata ctccttttta ttttttctat gctggattcc agcagtgtat
     1801 tggctgtctt taaaaaacag tcaattagtc ctcacaaaca taatatacta ctattgtttg
     1861 aagaagtcaa cagtttgtgt ttgtttttgt tatttatttt ttactttttt tataaaactt
     1921 ctatctcaaa ccctaattct tcaacctgat tggcttctaa gagacaaaca ttcttcttat
     1981 cttctaaatg atctccttct tcaaggaatg ttgacaagcc agaccatggt tcaaaggtaa
     2041 tgaaaggtcc cttgttcaaa gttgaccaga tgatgaggtt tggaaattct gcaaaatgca
     2101 ctttcaatcc cttatcatgt ttaagagaac gaagggcaat tgttcgagat tgcaattcat
     2161 ccaaagtcac tgcatctgtg ctgaaaagat cataactaag atctatttct ttttgtccct
     2221 ctagccatgg acttctatct tggaaatcca acatacctgt ttctgggaaa ggacgtggaa
     2281 cagagcaaat ctcttctttc tcaaactcta gataataatc ttcatagact tcatcatcaa
     2341 gtagaagaca attaaatcct ggatgtccac caataaagta aggcctgacc ttgctagttt
     2401 ctttattaga cttcctgcaa aactagaatc ctagttcatg attgataatg ccagcaatca
     2461 aattcattcg taatccgaag cgtttacgat gatttcgata ggttgttgaa aacattttaa
     2521 acgtttttac tttggcaaag atgttctcaa ccttgcttct cccttagata gcgcatggtt
     2581 acaggcttta tcttcagctg ttagcggctt gagtttgctg gatttacgtg gagtttgtgc
     2641 ttgaggatat atcttcatga gcccttgata accactgtcg gccaagattt taccagcttg
     2701 tccgatattt ctgcaactca ttttgaacaa cttcatatca taacaaatag ttcacagcga
     2761 tatccaaaga aacaattctc ccttgacttg tgacaatcgc ttgagccttc atagcgtggc
     2821 atttcttttt accagaatca ttcgctaatt ctttttttag ggcgattgat ttgtacttcc
     2881 gtcgcatcaa tcattaccgt gtcctcagag ctgagaggag ttcttgaaat cgtaacacca
     2941 ctttgaacaa gagttacttc aacccattgg ctccgacgga taaagttgct ttcgtggata
     3001 ccaaaatcag ccgcaatttg ttcataagtt cgatattctc gcacatattg aagagtagcc
     3061 ataagaaggt cttctaggct taatttaggt tttcgtccac cttttgcgtg tttaagttga
     3121 taagctgttt ttaatacagc taacatctct tcaaaagtcg tgcgctgaac accaacaaaa
     3181 cgcttaaatc gtgcatcagt tagttgttta cttgcttcat cattcataga actactatac
     3241 catgttttgt ttcgcaggga gtctaatatt gtcaaatact ggagcgctca ttgctggtat
     3301 acggaataag attggcccag cttcgataac tgggatacct ggttcaaaac caaaatctgt
     3361 tgcagcgatt ggtgtaaaga tatcgtaacc tttcataagg tcttcgttta catctttcac
     3421 catgactgca tcacagtgaa catcataacc acggtttgaa agttcttctt ctagagcact
     3481 tttaatttgg taactcgagt taacacctca ccgcaggcag caagaatttt aatcatttgg
     3541 atttcctccg attttatttt ttaatagaca agattaagcg attgcttcag caatgtaagc
     3601 ataaagtttt tctggttcgg aaatttttga taaatcttca agatgtccat ttcctgtgaa
     3661 aaagtccatc aactgagcca gaatatttgt ttgacttgaa cttgaattgt taatgataaa
     3721 gaagagtagg gatacttcta cttccttatc aggagctatc atattgtgaa aagttactgg
     3781 tttttctaat cgaacaacca ccactttttc agctagatta tgaacaatat ctgtgtgagg
     3841 aatcgctaca tttggcaagt cctttcctag aaattccata tctaaaccag ttggaaatga
     3901 cttttcacgc gtgatcaagg cttcacgata agttggagtg acaatttctc gttcttccaa
     3961 caagcttgct acctgatcaa agagttgttc ttgattatcc gcttctaagc aaaacacaag
     4021 gtttttgtca aagaaataat ctaataccat aaggttttcc cttctttcca ttaactttat
     4081 gctataagta taacactata tgaaatcgtt gttaattact ttctattctt ttttgtctct
     4141 ttttttatat ttttgttttg tttatagttt gttatataaa aataaacaca caaacaaata
     4201 ctccaagcat ttttctgttc taatactcaa tgaaaatcaa agagcaaact aggaagctag
     4261 ccgcaggtta ctcaaaacac aattttgagg ttgtagatga aactgacgaa gtcagtaacc
     4321 atacatacag taaggcgacg ctgacgtggt ttgaagagat tttcgaagag tataaaaact
     4381 aaaaaagcag accatctaag cctgctttac tattgattct tatataaatt tcctgtgaac
     4441 aaggaaaggc atttctgata acttattctt catccatact caagacgctg aggaaggctt
     4501 cttgcggaac ttcaactgat ccgatggatt tcatgcgttt cttaccagct ttttgttttt
     4561 caaggagttt acgcttacga gaaacgtcac caccataaca tttagcaagt acgttcttac
     4621 gaagggcctt gatatcagta cgagcgacaa tcttgtgtcc aatagccgct tggattggaa
     4681 cttcaaattg ttggcgaggg atgattttct tgagtttatc aacgatgagt ttcccacgtt
     4741 cgtaggcaaa gtccttgtga acgataaagc tgagggcatc caccttatct ccattgagaa
     4801 ggatatccat tttcaccagc ttagatgggc gatattctga caattcgtag tcaaagcttg
     4861 cataaccacg tgtcgaagac ttaagtttat caaagaagtc aaagacaatt tcagcaagag
     4921 gaatttgata gataacattg acacggttat catcaatata gtccatagtc acaaagtccc
     4981 cacgcttacg ctgagctagc tccattactg ctccgacgaa ctcctgtggt accatgattt
     5041 gcgccttgac ataaggctct tcaatggtcg caatcttagt tgggtctgga aactcagatg
     5101 ggttagacac atccatagac tcaccgtcgg tcaaattaac tttgtaaata acagacggag
     5161 ctgtcatgat gaggtcaata ttgaactcac gctctaaacg ttcctggata acatccatat
     5221 ggagaagtcc aagaaatcca caacggaaac caaatccaag tgcctgagat gtttctggtt
     5281 caaactgaag actagcatca ttcagttgca atttttcaag cgcttcacgc aggtcattgt
     5341 atttgtttga ttcgattggg tagagacccg caaagaccat aggattcatc tgcttataac
     5401 catgtaatgg ttctgccgca ggattggttg ccaaggtaac ggtatcaccc acacgagtat
     5461 cctgaaccgt cttgatagac gccgcaatgt aaccaacatc accagtcgca aggaaatcac
     5521 gaccaaccgc ttttggtgta aaaataccga cttcggccac atcaaaggtc ttactattgc
     5581 tcatgagctg aatcttatca ccaggtttga ccactccgtc catgacacgc acttggagga
     5641 taaccccacg gtaagcatcg taaacagagt cgaaaatcaa ggccttaagt ggcgccgtca
     5701 catcacccgt tggtgctggt actttttcta caatttgctc gaggatttct tcaatcccaa
     5761 tcccagcctt ggcagaagcc aaaactgctt cactggcatc caaaccaatc acatcttcaa
     5821 tctctgtacg cacgcgctcc ggatctgcag ccggcaggtc aattttatta atgataggca
     5881 tgatttccaa atcattatcc aaagccagat aaacgttggc aagagtttga gcctcaattc
     5941 cttgagccgc atcgaccacc aaaatagcac cctcacaggc agctagcgaa cgtgaaactt
     6001 cataggtaaa gtcaacgtgc cctggtgtgt caatcaagtg gaaaatataa gtttccccat
     6061 cttttgcagt gtaattcaac tcgatggcat tcaacttaat agtaattcca cgttcccgct
     6121 ctagatccat gctatccaaa agctgggcct gcatttcacg acttgaaacc gtctctgttt
     6181 tttccaaaat gcggtctgct agagttgatt tcccgtggtc aatatgggcg ataatagaga
     6241 agttacggat cttcccctgt cgttttttca attcttctaa gttcatgatt ctcttccttt
     6301 cagggtatct atttattata aattgttttt gatattttga caagaccata ccctgctagg
     6361 agtactaatc ttcagcgaca aagccgtcat tttcgataaa gtggtgttct gtcattcctt
     6421 ggtctgtaaa gacaatcccg tgaaggacac caccataaac agctcctcca tccattccaa
     6481 tcttgccatc ttctgtagtc caaagctcag atgtaccgcg ttcttgctgt aacaaaccat
     6541 agaccggtgt atgaccgaag acaatggttt ttccagtatg attttcagct ccgtggaatg
     6601 gttttctaag ccatactttt ttataatctg ttgtttcatg ccagtcgtcc aaggtcaaat
     6661 caatacctgc gtgaacaaat atatacttgt ctgtctctac tacaaatggc atttgacgaa
     6721 tgaattcgac caagtctgac gcttcagcgg caacccgctt ggcatcttct actccatcaa
     6781 ctggtgcatc caagggacga cctaggatag agttaatggt tgtatctcca ccattgcgac
     6841 gataatggtc ataactttct tctgggtcat ctagccaagt caaaaacata tactcgtggt
     6901 ttccagacaa acagatagcc ccttgattgt ccaccaagtc cttgaccatt tcaagaacac
     6961 ggtgactatc ctcacctctg tcaatcaaat cacctagaaa gagcaactgg gtctgaccat
     7021 cccaggtttt gagaaggtct tccagcatcc cagcttttcc gtgaacatct ccaattacat
     7081 aataatctgt catcttattt ctccctgttt ctcaacaatt ctctggcttg cgtcagggct
     7141 gcttctgtca catcatcacc tgccaacatc ttggcaactt cctccactcg ctcttcgacc
     7201 gtcaagagac gaacagtcga aaccgttgaa tggtcattac taatcttctc aataaagaat
     7261 tgataatctg caatcgcaat tacttgtggc aaatgggaga tagccaaaac ctgaccatgc
     7321 tgaccaattt tatgaatttt ctgagcaata gcttgagcaa cacgacctga aactcccgta
     7381 tccacttcat caaagacaat gctagtcttg ccttctttac gtgaaaaggc agacttaatg
     7441 gctaacatga gacgagataa ttcccctcca gaagcaacct taaccaaggg tttaaagtct
     7501 tctccagggt tggttgaaat ataaaactca accatttcat ttccctcacg actgaatttt
     7561 cccttactaa aacgaacctg aaactgggct ttttccatat aaagatcttg cagttcttgt
     7621 ttaatctcag cttcgagttg ctgagccaaa ttatgacgag cagaagcaag ttgacctgcc
     7681 aaattgacaa gattgacttc caacttctta agctctgctt ccatgtcctc agacgaaaga
     7741 ttattgcctg tcaagagatt gtattcttcc gtaatcttgg caaaataaag caaaacatca
     7801 tcaacagtcc caccatactt acgagtaata gtatgaagga ggtccaaacg attctcaacc
     7861 tgcatgaggc gattgccatc aaaatcaagg tcctcaatga tagcttccaa acgtttgcta
     7921 atgtcttcta aaacatagta ggtctcagac agagagcttg aaatttcacg gtattcaggg
     7981 tcatactctt cgacactttc catgtcattc atggctgaac gaacattggc cagacttgaa
     8041 aaatcttcat tgtccaacat actgtaggca ttggtcagtg tatccgcaat atttttgtgg
     8101 ttgaggagtt tatctcgctc ttgattgaga gccaagtctt ctccagcctg caagtttgct
     8161 gcctcaatct ctgccatttg aaattccaac atttcgatac gtgccttgtg ttcctgttgg
     8221 tttttcttga cttccagaac ctgcttgcgc attttccgat aggcatcaaa actcgtttga
     8281 taggtttctt tcaagtccca aaaagcggca tcaccaaatt catccaacat ctggatatgc
     8341 agttggggac gcattaactc ctcatggtca tgctgaccat gaatatctac aagatgttgc
     8401 ccaatagttc gcaaaacaga cagattaacc atctgaccat ttacacggct gatactacga
     8461 ccattttgca agatttcccg acggatgata atttcatcac ctaattctaa accttgctca
     8521 tcaaaaattt cctgtaaaag acgactattc tcaactgaga aaagcccttc aatctctgcc
     8581 tttggtgcac catgacgaat aacatctgtc gtcgcacgag ctcccaacat catattcatg
     8641 gcatcaatga taatcgactt ccctgcaccc gtttcaccag tcaggacagt catccccttt
     8701 tcaaaattga gggaaatagc ctcaataatg gcaaagtttt ttatcgaaat ttcaagtaac
     8761 atatagacct accaattttt tacttgttca aagatttcct ctgctagact tccacttctg
     8821 gcaatgacta aaatcgagct atcatcagtc aaacagctaa aaatcttgtc tgcaaaagtc
     8881 tcgattaact gagcttttac aaaagccgta tttcctggaa taacttggag attgatcatc
     8941 ttatccatca attcagccga ttcgatattg tcttcagcca gttgcagact ttttacgatt
     9001 gattttggta attcgtagac ataggtgttg tctctcaaag gaattttgac aatacctaac
     9061 tctttgatat ctcgggatac cgtcgcctga gtggcagtga tacctgcttc tttcaaatgt
     9121 tctacaattt cttcttgcgt gccgatttga taatctgtca ccaatcttct aattttttca
     9181 agtctctctt ttttattcat ttttaaattg actatgcgcc ctctctactg cttctttaat
     9241 ctcagcaaaa atctgattgc ttgctgactt ttcttttttc aaatacgcta aaaattcaat
     9301 atttccatgt ccaccttgga tgggagaaaa gtccaagcca aggactgaaa aacctgcctc
     9361 tactgccata gctgttacag attcaaggac attctgatga atcttagcat ctcgaataat
     9421 tccatttttc ccaatctgct cacgtcctgc ctcaaactga ggtttgacaa gtgctaccac
     9481 ctgaccttga tcagccaaga cacgatgcaa ggctggcaaa atcagactaa gggaaatgaa
     9541 actcacatca atactggcaa agctcggctc ctgctcgaaa tcagtctttt cagcatagcg
     9601 gaaattgaac tgctccatgc taacaactcg tgggtcttgg cgtaatttcc aagccaactg
     9661 attggtacca acatcgactg caaagaccaa cttggcacta ttctgtagca tgacatcggt
     9721 aaaacctcca gtagaggccc cgatatcaat cgtagtcgcg ccatccaccg acaaatcaaa
     9781 gacctgcaag gccttttcca gtttcaaacc accacggctg acatacttga gtttctctcc
     9841 cttgagtttt aattcggtgt catctggaat tttctctcct ggcttgtcaa accgttctcc
     9901 attaaggact gctacgacta ggccagccat tacacctcgc ttggcctgct ctctcgtttc
     9961 aaacaacccc tgtttataag ctagtacatc cactctttcc ttagccattg attctcaaac
    10021 tttctactac acttacaatc gattctgttt caaagggaag ctgctgggca atttcttcta
    10081 atttttcatt agcttgatcc agggtttggt tacaaaaggc aatggactct tccaagccca
    10141 acagggcagg ataggttgat ttttctgcct gcagatcctt ttgaggtgtc ttgccgattt
    10201 cctcaaaact agctgtcaca tccagtacat catctctgac ttgaaaagca agtccaatca
    10261 attcacccac agttttcagc ttcacctgca tttcaggtga caattcagct ataatagctg
    10321 ccgcttggaa gggataggct agtaacttcc cagtcttatt ggcatgaata atctgaagtt
    10381 cttccaaaga caagtgctgg tgttcgccct ccatatccaa aacttgccct gccaccatac
    10441 ccagactacc tgaagcaagg gataagttgg caatcaagtc caccttaatc tgacttggca
    10501 aatctgcctg cgcaatcaag gcatatgggt ctaagaataa ggcatctcca gccaaaatgg
    10561 ccatagcttc accgaatttc ttgtgattgg ttaaccgccc tcttcgataa tcgtcatcat
    10621 ccatagcagg aaggtcatcg tgaatcaagc tccctgtatg aatcatctcc aaggcagtag
    10681 ctacctgcgc gtgagcaggt ttgatggtaa cctgcaaggc ttccagaact tctaacaaga
    10741 gaaaaggccg aatacgcttg ccaccagcat gaatagaata gagaacagac tcccgtaaac
    10801 tagaggcaaa ctgctggtct ccataaaaat cttccaaagc cgactcgaca agagctaatt
    10861 tttcttgctt tttcattcaa aatcactttc tgttccgtct tcttgcatga ccttgaccaa
    10921 ggtcttttca gccttgtcca gcgtagcttg gagctctttt gacaagacca tgcccttttg
    10981 aaaggcagta atcgcatctt ccagagcaat ttcaccattt tccaaacttt ggacaatggt
    11041 ttccagttct gctagatttt cctcaaattt cttttgtttt gacatcttta acctctaatt
    11101 ctacttgacc atctcgcatc aaaagcgtta cttggtcttt tttcttcaaa ctctcaaccg
    11161 aatctacaat ggactcttct tttttgacaa tagcataacc acgcgccacg attcggctag
    11221 tatccaacat gagcaaagct tccgaaagtc gcttggcctc agcaaccttg gcgtcataaa
    11281 ctaacgccat ttggctacct aagagcttgt ccaactgtcc taaacggtct tgatagcgtt
    11341 ggattttggt aacaggtgat aattgtacta attgatgagt tcttgcttga actaattgtt
    11401 tgttatcaga aatccgagtt cgcaaacttt gtttcaaacg cagttgcagt tggtccaagc
    11461 gttgcaaata accgtcatac aagcgctcag gttgtctaaa gataacagac tgactgcatt
    11521 ttttcaaagc ctcttgtttc ttagatagaa catttcggac tgccgttgcc atccgttttt
    11581 cctgattttg caaatgagtt aatacatcca acttggtcac aggtgttgcc agttcagccg
    11641 ccgctgttgg cgttgcagcg cgtcgatctg ccacaaaatc tgccaaggtc acatccgtct
    11701 catgccccac actagagata actggcaaac gagattcaaa aatagctcgt accacaattt
    11761 cttcgttaaa ggcccagaga tcctcaatag aaccacctcc acgaccaata atgagcaaat
    11821 ccaaatcgtc ccgttgatta gcacgcgcaa tatttctagc aatttcctcc gcagcccctt
    11881 caccttgaac cttggtagga taaagaagga tgtcaacacc tgggaatcgc ctgctgacgg
    11941 tcgtgataat atctcgaata acggctccac tacggctggt tactacccca attctcttag
    12001 aaaattgggg tagagcttgc ttgaagcgtt cttgaaacag gccttcttct gtcaattttt
    12061 tcttaagttg ttcaaactga atcgcaagcg ccccaacccc atcaggctca gctttttcaa
    12121 tgatgatgga gtagctacca cttggttcat agacctgtac acgcccaatc acattgatct
    12181 tcattccttc ttccaggtca aaccctaatt tctgataaat cccagaccag atggtcgctt
    12241 gaataactgc atggtcatcc tttagggaga aatattggtg agtaggtcgt ttacgaaagt
    12301 tggaaacttg accagttaaa tagacccgtt ccaagtatgg gtctttatcg aatttcattt
    12361 tcagatactt ggtcaaagtt gttaccgata aatacttttc catctccacc tactattcat
    12421 ttacttgctc tttcatgggt attattatac caaaaatatg cctaaaaatc tccatttatg
    12481 taccattatg agggaaaaat agaaaaagga ggcaaggcct ccacatgtga ttatttgctg
    12541 tttcgagctt cttccaaaat ctttgcaatc ttggtcgtca acaggtcgat agccacggta
    12601 ttgctaaccc cttcaggaat gacgatatca gcataacgct tagttgactc gataaactgg
    12661 tggtacattg gtttgaccac acctaagtac tggttaataa cgctatcaag gctacggcca
    12721 cgctcctcca tatcacgctt gatacgacga ataatgcgca catcgtcatc cgtatccaca
    12781 aaaatcttga tatccatcaa atcgcgcaga cgcttgtcct ccaagaccaa aatgccctca
    12841 acgataaaga catcttgagg ctcctgacga taggtcttgc tactccgtgt atgctctgta
    12901 tagtcgtagg tcgggatgtc caccggacgc cctgccaaca attccttaat ctgctcgatc
    12961 atcaagtctg tatcaaaggc aaaaggatgg tcatagttgg ttttgacacg ctcttcaaag
    13021 gtcaaatgag actgatcctt gtagtatgaa tcatgctcaa tcatggaaat cttttcatca
    13081 ggaaaatgcg ataaaatggc tcttgaaaca ctggttttac caccaccaga accacctgtc
    13141 actccaataa tgattggtct attttgcatg ctatcctccg ttattttatc cgtcgtctat
    13201 tctatcacat tttttacaaa atttatagtc tcatcagcaa aaaacaccag agtcttccct
    13261 ctgatgttcg acagttttaa cgaaagccct gtagggtttg agcaagcatc tgcaagaaag
    13321 ccagtctccc tctttcctgg ctaggagctt tggcaatcca taaaccaaaa tcaatgacag
    13381 acttaggtgc ctggtaatga tgcgtcatga ggtaaagtga caacccttga ctcaaattgg
    13441 ccatgaccgt ttggtatttt tcatttctgt ctaaattttg tatagcaaga cgaaacaggt
    13501 gactcaactc actattttca tttatttctt tttgttgaag aagttgctcc accctttctc
    13561 gaaactcatt tcgcatcatg gaattatcac accaaatcct gggcctaagt tcccaccaga
    13621 acctgtaatg gactctaaat atttatctga aagaatttta agttgcttca tttcacacct
    13681 ctaaatttct atatagatta tttgagtatc tacaactcgc aacaattgga atattataat
    13741 tcccaaaacc attctactat tagtatgggg ttttatcaag caattgttat ctatcacccg
    13801 atttttattc ctaaacgatc tagctaaaaa ccttccttgg cttatagaga ttgccccgtt
    13861 tttctagaat ggctaacaat ttatcatctt caaaggcagc cagttctttg tccgtttggt
    13921 ctagctcaat aaaacgacca aagcgaactt ctgtagcatc ttctggagtt aggaaaactt
    13981 tgacaaggtc acctgtccca atctctaaag gatggagaaa atctaattgc ccagcctcta
    14041 ctttttcagc aatttcctcc aaggtaagag catcttctaa ttgtaagcca gcagcactag
    14101 tacgagtcaa atgggacata tgagccgcat aaccaagctt ttcacccaaa tcaactgaca
    14161 aagtacggat gtaagtccct ttactgcatt ttacacgaaa agtgaatcgg gcaagttggc
    14221 catcataaga aatcggactt gttcgctcaa attgataaat ggtcacctga cgttctggac
    14281 gctccacttc ctgaccagca cgcgcatact catagagctt gcgaccatta accttaactg
    14341 ccgaatacat agggggaatc tgggtaatag gcccagtcaa gctagcaatc gcttcatcaa
    14401 caagcttttc atccaatgaa gacaaaacag gggtttttgc gaccacttcc ccactagcat
    14461 cctcagtcgt cgtggaatag cccagaatga tttccccctc atagatctta ccctcgtcct
    14521 gcataaactc gaccatgcgt gtcgccttgc caaccgcaat cggcaaaaca cccaccacat
    14581 ccggatccaa ggttccacca tgaccaattt tcttggttcc caaaatctta cgcagtttaa
    14641 aaaccgcatc atgcgaggtc attcctgctt ctttttttaa gttgataata ccgttcattt
    14701 ttgctttcta ctcccccttc agtgcttcga acttcgcttt cattgttgga tttttccggg
    14761 tcaatttttt aacagagaca tcttccaatt tgttgttagc tagacggagt tggttttcag
    14821 atgtagtcag gaatttctta acctcttcca tgcgtttgat ggccttgtcg atttcatcaa
    14881 tagcttttcc aaagttagtc gaagctgaat tatagttctt agcaaaagct agcttaaagg
    14941 catccaagtc ttcctcaaaa tgcataatgt caatattttg ctcgcgaacc aaggccaact
    15001 cctgcttgta ttttagggaa tttagcgccg cattacgtaa gagaccaatc aattggataa
    15061 agaattgagg acgaacaaca tacatttttt catactcgtg actgacgtca acaatccctg
    15121 tgttaaagta gtcattatca gcctcaagca tggtcaccaa aacggcatac tcacagttct
    15181 tctcccgacg gtccttgtcc aattccttgt aaaaatctgc attcttgtgc ttcttctctg
    15241 ttccgtccgc ttcgtttttc atctcaaaca tgatagaaat gatttcaact ccattttcat
    15301 cacactcacg gaagataaag tcccctttag acccacgcga agagaccttg ttatccttct
    15361 caaagtaagc atttggaaag gcgaaactac gaaccttgtt aaactcactc tctgcatact
    15421 gttctaggct ttccccaatc gcttttgtag attgttgagc cttaaaattc ttataaaact
    15481 cgacttgttc actggctgct ttgagctggg cttcgtagtt ttgcttaaca gaagccaaag
    15541 acaactcatt ttccttttct tgcagtagga gctgattttt gacctgattg cgttcttttt
    15601 ctaggtcaga aagggtcttt tgcaattgat tttcatgctc caaacgcaag gtcgccaact
    15661 ggttttccaa ggcctgtact tccttgtcct tagccaataa ggcctgatgg cttgtctgtt
    15721 caacttcttt cttggccaat tctttttctg tatcaaagtt ttggatttga ctctgcaatt
    15781 gcgcaatttc ttgatccttc tgagccagtt tagtctgttg ctcattcata gccttttgct
    15841 cagccaaggc cagttcctgc ctcatcctat cgtgtagttc cttatcaaac tctgccgttc
    15901 tcacttggga caaaagttca gcatactggc tttcatttac tgtaaagact tccccacagt
    15961 tgggacattt gatttcgttc attacattcc tctttctaga cttctgtaac cattatatca
    16021 tgcctgaggg aaaatcaaaa acagtgagtc aaaacccact gtttatcttc ttttacttta
    16081 aattttttcc aaggccaagc gtaagtcttc aatcaaatct tctacatttt caagaccgat
    16141 agacaagtgg atttgatttg gtgtgacacc tgctgcttct aggtcttttt ctgacaattg
    16201 accgtgagtg attgttgctg gatggacaac aagcgattta gcatctgccg cgtttgcaag
    16261 gtcagaaaag atttctaaat tatcaatgac cttgcgtgct tcctcctcgt cacctttgac
    16321 gtggaaggta aagattgaac cgacaccttt tggcaagtat ttctcagcca aggcataata
    16381 aggactatct gcaagttttg gataatttac cttttctacc ttaggatggt tgacaagaaa
    16441 atcaacaatt gtctcagcat tttgtacatg gcgttccaca cgaagtgaaa gggtttcaag
    16501 tctttgtagc aagaggaaag cattgaatgg tgacaaggct gcacctgtat cacgaagcaa
    16561 ttgaactcga acagctataa taaaggctac tgcacccaca tcacgagtat agctcaaatt
    16621 gtggcagctt gaaccctcgt caacaaattg agggaatttc cctgaagcca tccagtcaaa
    16681 acgaccacta tcgacaatta ttcctccaat agttgtacca tgcccaccga taaacttagt
    16741 cgcagagtga atggcaatgt caacgccatg agagaagacg ttaatcaaat aaggtattgc
    16801 aaaagtattg tctgacacaa gtgggatttg atgtttatga gcaatctctg ccagtttttc
    16861 caggtctgga atattaatca aggggttacc caaggtttca atcaagacaa gcttggtatt
    16921 gtctttgata gctgcttcta cttcctccaa attatcaaca tcgacaaagg ttgttgtgat
    16981 accataacga ggaaggggtt ctttcaaaag attgaaggtt ccaccgtaaa tagtcgaagc
    17041 agccactaca tggtcaccag catgggcaag cgccaaaatc gtataagtca ctgcagtcat
    17101 acctgatgct gttgctagcg cttcaacacc accttcaagg gcagctgttg taggattggt
    17161 gatacgagta taaatgttcc ctggtttcct caaggcaaac agatcggcac cttcctacgt
    17221 gtcatcaaaa acaaaagatg ttgtttgata aatcggcact gcacgagact tagtagctgg
    17281 agtcacaact tgaccagcat gtagttgtag agtttcaaat ttaaaatcac gagtcataag
    17341 gtgacctcca tattatttta ttaaggatat tgtagcacct tgagttatag tttacaaata
    17401 tcagttttct atattttgat ataagaaata gctattatct tattttgaaa atgaaaaaag
    17461 cacgactcaa tcgtgctcat tttcttaatc tacataagta tcttcgtttt tattgaggaa
    17521 ggcatatgga agacccatca agaggcctcc tccgataaag tttccgatga aagtcacacc
    17581 ccagtggcga agcatatttc caacaccgaa gttggcaatt gaatccgcag caacactgaa
    17641 tttcacaatc gcgaaagaag caaagttcgc cgcaatgtgc tcgtttgtta agaatacaaa
    17701 catgtaaata gctgacaaca caagccaaag tttggcacca ccatctttga ccaaaacaaa
    17761 tgaaagaatg gcaatgttta cgaaaatatt tgccaaaatc gcctcaagca agaccaattc
    17821 atttgagcgg cctaacttca tctctacaac ccctgagatg aaactatcgt gtgtcagatt
    17881 cgcataggct gccgaatgag caaagcccca ccctgctatc aaggctccga taaggttgaa
    17941 caaggtacag tatagtaaaa tctcagctgt ttttctccaa gagatttttt ttaataaact
    18001 accagcagtc aagaacatca tgtttgaagt gaccaactcg gcattcaaaa aaacaatgta
    18061 ggccaagccc caagcaaaaa cgaatggaaa gaggaagcgt ccactacctg gtgcaatttt
    18121 attaatcaag tcagccccaa ctgcacctgc agcagtactg aaggttaaaa atgcacctgc
    18181 gaacatcgaa cgaatcgcat acttaaattt gctttgacta taaagacttt ctttcttatt
    18241 gcaagcaaat tcaatctttg agataaattc tgaagaaacc ataataaact cctaaatctt
    18301 ttttcttgat aattatatca caaactttag gttttaggaa gcgttttcta tatttcataa
    18361 aagtttatag tagattgaaa ctagaatagt acacctctac ttctaaaaca ttgttagaaa
    18421 tcgatttgac tgtcctgaac gattcgtcct attcttattt cattttacta tatttttatg
    18481 aaaatcttaa aaaatcagtg aaatccatga tttcactgat ttgtattaat aaaattgttt
    18541 atatggttga ttgaaagctg ttaggatttc atcagatgtt tgtgaataat cttttgtttc
    18601 tttcaaatca cctttgacaa taatacgttc tgtagcagca aggtcttcac aggttactaa
    18661 tgtgatttca ttgaccccat ctctatcatc aacttcatca acacgatccg gtgtcacacg
    18721 tttgacttca cgtatttcat aagtataaac tttattttta tcggttagat aaatcttcat
    18781 gccattttta gcattatcta aaggagaaaa taacatttta ttagcattat caacaccaaa
    18841 gatatggtga ctagctagac tataatttcc ttctcccatt acttgctcgc gtttcattgt
    18901 accagctccg tagaagagat taacattatc aagtccttta aaaatcggca aattcatttc
    18961 caattcagga attgcaattc ccccaataac tggtaatttt tgagcatccc attgagaagt
    19021 tagaacagct tccgaagaga tagctttgac agaatcaaag tcaaaattgc cttctgtatc
    19081 ctgattttct tctaattttt cttttgatac ctggctaact tgatacttat tggtattcca
    19141 gactatgaaa atatttcgaa tttgagtatt aaaaatcaaa gccagtgaca gtaatatcag
    19201 aaatcctgct aggatatttg tcagcagatt ttttcgcttg tttttctttt tattattttt
    19261 ttgagacatt atgcttcacc ttctgtttcg ttttctgtcc caacttcttc tttttctgcc
    19321 accgcaaccg ttgtgaaagt cactatctga gcatcttgat ccaggcgcat tactttaact
    19381 cccatagttg cacgtcctgt ttgtgaaata ttggcaagat tggttcgaat catgacacct
    19441 gtatcagtga taatcatcaa atcctcatca ccttgaacag tcataagacc ggccagcaag
    19501 ccattttttt cggtaatttt agctgtctgc attcccttac caccacgacc ttttgttggg
    19561 tattcagtag cgactgtacg cttaccatat cctttttctg tgataataag aacctcatct
    19621 tgatcagtaa tcaagctggc accaacaact gtgtctcctt cacgaaggtt aacacctttc
    19681 acaccagtgg cgatacggct cataccacga acggctgatt gattaaagcg aactgcataa
    19741 ccaaacttgg taccaatgat aatatccata tctccttctg tcaacaagac attgattaac
    19801 tcatcttcat cctttaaatt cagcgctttg agaccatttt gacgaatatt ggcaaactcc
    19861 ttaacactag ttctcttcac aataccgtga cgggttgtaa agaagagata agcatcatca
    19921 ctgcgatcag actcaacatt gataaccgtc tgaatacttt catcttcatc caatttcaag
    19981 agattgacta ctggtagccc tttggcagtc cgaccatact caggaatttc ataaccttta
    20041 agacgataga cacgtccctt gtttgtgaag aagagcagat gatcatgggt gctagttgac
    20101 actaactcac gaacaaagtc atcatctttc actcccgttc cttggacacc acgaccccca
    20161 cgtttttgag cagtgaactc gtcctgatcc aaacgcttaa tgtagcctct gttagaaagg
    20221 gtaatcaaga catccgattc ttcaatcaag tcctcatcct cgagactcaa gatctgtcca
    20281 accatcaact ctgtacggcg tttatcagaa aatttacgtt taacttcatc caattcgtct
    20341 ttgataattt gagaaacacg ttcaggctta gcaagaatat ctgctaaatc cgcaatcaga
    20401 gccaagaggt catcatactc agattgaatc ttatcgcgtt ccaaacctgt caaacgacga
    20461 agacgcatat caaggatagc ttgactttga cgttcagaaa gcttaaactt gctcatcaac
    20521 tcagcttgag cttccgcatc cgtttcacta gcacggatga tacgaatcac ttcgtcgata
    20581 tggtctagcg caatcaagag accttctaag atatgagcgc gcgcttccgc tttttcctta
    20641 tcaaaacgtg tacgacgaac aaccacttct ttttggtgct cgatataagc atccaaaatc
    20701 tgacgaagag acaaaatttt cggtatacca ttttggatag cgagcatatt gaaaccaaaa
    20761 ttggtttgca tttgggtcat tttgaagagg ttattgagaa taacattggc tgaggcgtcg
    20821 cgcttgactt caataacaaa tcgaacacct tcacggtttg actcatcacg tactgc
//
