LOCUS       NC_011900              13099 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Streptococcus pneumoniae ATCC 700669, complete sequence.
ACCESSION   NC_011900
VERSION     NC_011900.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptococcus pneumoniae ATCC 700669
  ORGANISM  Streptococcus pneumoniae ATCC 700669
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Croucher,N.J., Walker,D., Romero,P., Lennard,N., Paterson,G.K.,
            Bason,N.C., Mitchell,A.M., Quail,M.A., Andrew,P.W., Parkhill,J.,
            Bentley,S.D. and Mitchell,T.J.
  TITLE     Role of conjugative elements in the evolution of the
            multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F
            ST81
  JOURNAL   J Bacteriol 191 (5), 1480-1489 (2009)
   PUBMED   19114491
REFERENCE   2  (bases 1 to 2221315)
  AUTHORS   Croucher,N.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-SEP-2008) Croucher N.J., Pathogen Genomics, Wellcome
            Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
            Cambridge, Cambridgeshire, CB10 1SA, UNITED KINGDOM
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 00:47:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,268
            CDSs (total)                      :: 2,195
            Genes (coding)                    :: 2,039
            CDSs (with protein)               :: 2,039
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 156
            CDSs (without protein)            :: 156
            Pseudo Genes (ambiguous residues) :: 0 of 156
            Pseudo Genes (frameshifted)       :: 82 of 156
            Pseudo Genes (incomplete)         :: 70 of 156
            Pseudo Genes (internal stop)      :: 58 of 156
            Pseudo Genes (multiple problems)  :: 45 of 156
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:23:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 42410
            Orig. end                         :: 55509
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FM211187.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..13099
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..13099
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13099
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:8099](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8099
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(139..1149)
                     /locus_tag="SPN23F_RS00275"
                     /old_locus_tag="SPN23F00520"
                     /old_locus_tag="SPN23F_00520"
     CDS             complement(139..1149)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /locus_tag="SPN23F_RS00275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00520"
                     /old_locus_tag="SPN23F_00520"
                     /product="YeiH family protein"
                     /protein_id="WP_000009180.1"
                     /transl_table=11
                     /translation="MSFLSKNGAGILVCLLISIVSWYLGGFFPVIGAPVFAIFMGMLLH
                     PFLSSYKQLDVGLTFSSKKLLQYAVILLGFGLNISQVFAVGQSSLPVILSTISIALIVA
                     YLFQRFFALDTKLATLIGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVLAAL
                     IFPTLGTWLHLSSDGFALFAGTAVNDTSSVTATASAWDSLYQTNTLESATIVKLTRTLA
                     IIPITLFLSYWQSREQKNKQGLQLKKVFPLFILHFILASLLTTLLTSLGVSSSFFTPLK
                     QLSKFLIIMAMSAIGLKTNLVAMVKSSGKSIVLGAVCWIAIILTSLGMQTLIGIF"
     gene            1298..2467
                     /locus_tag="SPN23F_RS00280"
                     /old_locus_tag="SPN23F00530"
                     /old_locus_tag="SPN23F_00530"
     CDS             1298..2467
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     9.6e-64. Score: 207.7. Matches aSDomain:
                     nrpspksdomains_SPN23F_RS00280_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="SPN23F_RS00280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00530"
                     /old_locus_tag="SPN23F_00530"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_000366348.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3e-62, bitscore:
                     207.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 3.2e-07, bitscore:
                     26.6, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.5e-07,
                     bitscore: 27.3, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEVFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPATFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        1391..2443
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SPN23F_RS00280_Aminotran_1_2.1"
                     /evalue="9.60E-64"
                     /label="SPN23F_RS00280_Aminotran_1_2.1"
                     /locus_tag="SPN23F_RS00280"
                     /protein_end="382"
                     /protein_start="31"
                     /score="207.7"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEVFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     TFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     gene            2464..3234
                     /gene="recO"
                     /locus_tag="SPN23F_RS00285"
                     /old_locus_tag="SPN23F00540"
                     /old_locus_tag="SPN23F_00540"
     CDS             2464..3234
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="SPN23F_RS00285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00540"
                     /old_locus_tag="SPN23F_00540"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_000616164.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            3231..4223
                     /gene="plsX"
                     /locus_tag="SPN23F_RS00290"
                     /old_locus_tag="SPN23F00550"
                     /old_locus_tag="SPN23F_00550"
     CDS             3231..4223
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="SPN23F_RS00290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00550"
                     /old_locus_tag="SPN23F_00550"
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_000717451.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKP
                     YLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEGRDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLSGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            4229..4462
                     /locus_tag="SPN23F_RS00295"
                     /old_locus_tag="SPN23F00560"
                     /old_locus_tag="SPN23F_00560"
     CDS             4229..4462
                     /NRPS_PKS="Domain: PP-binding (8-72). E-value: 3.2e-11.
                     Score: 35.4. Matches aSDomain:
                     nrpspksdomains_SPN23F_RS00295_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /locus_tag="SPN23F_RS00295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00560"
                     /old_locus_tag="SPN23F_00560"
                     /product="acyl carrier protein"
                     /protein_id="WP_000136449.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-10, bitscore:
                     37.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.00033, bitscore:
                     17.9, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQSVGDVVKIIQGK"
     aSDomain        4253..4444
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SPN23F_RS00295_PP-binding.1"
                     /evalue="3.20E-11"
                     /label="SPN23F_RS00295_PP-binding.1"
                     /locus_tag="SPN23F_RS00295"
                     /protein_end="72"
                     /protein_start="8"
                     /score="35.4"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQSVGDVVK"
     gene            <4508..4799
                     /locus_tag="SPN23F_RS11730"
                     /old_locus_tag="SPN23F00561"
                     /pseudo=""
     CDS             <4508..4799
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="SPN23F_RS11730"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SPN23F00561"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RNIGQAGKILADSGYQGLMKIYPQAQTST"
     misc_feature    complement(4516..4531)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(4840..4853)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     misc_feature    4861..4874
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.29"
                     /tool="antismash"
     gene            5001..5231
                     /gene="blpU"
                     /locus_tag="SPN23F_RS00300"
                     /old_locus_tag="SPN23F00570"
                     /old_locus_tag="SPN23F_00570"
     CDS             5001..5231
                     /codon_start=1
                     /gene="blpU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="SPN23F_RS00300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00570"
                     /old_locus_tag="SPN23F_00570"
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="WP_001093075.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.4e-16,
                     bitscore: 55.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKKMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAVRGLQL
                     GIKTRTWQGAATGAAGGAILGGVAYAATCWW"
     misc_feature    5018..5032
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.48"
                     /tool="antismash"
     gene            5234..5359
                     /locus_tag="SPN23F_RS14050"
                     /old_locus_tag="SPN23F00580"
     CDS             5234..5359
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="SPN23F_RS14050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00580"
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            5946..8099
                     /gene="comA"
                     /locus_tag="SPN23F_RS00315"
                     /old_locus_tag="SPN23F00590"
                     /old_locus_tag="SPN23F_00590"
     CDS             5946..8099
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="SPN23F_RS00315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00590"
                     /old_locus_tag="SPN23F_00590"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_000668272.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.9e-42, bitscore:
                     141.2, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1123.6,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMIFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPILVK
                     QRGLIANIVLATLLVIGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            8112..9461
                     /gene="comB"
                     /locus_tag="SPN23F_RS00320"
                     /old_locus_tag="SPN23F00600"
                     /old_locus_tag="SPN23F_00600"
     CDS             8112..9461
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="SPN23F_RS00320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00600"
                     /old_locus_tag="SPN23F_00600"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_000801611.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKVTASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKYVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            9631..10338
                     /gene="purC"
                     /locus_tag="SPN23F_RS00325"
                     /old_locus_tag="SPN23F00610"
                     /old_locus_tag="SPN23F_00610"
     CDS             9631..10338
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /locus_tag="SPN23F_RS00325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SPN23F00610"
                     /old_locus_tag="SPN23F_00610"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043310.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNVAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQGLK"
     misc_feature    complement(10409..10422)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     misc_feature    11120..11134
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    11880..11890
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 cgttttgagg ttgcagatag aactgacgaa gtcagctcaa aacaccgttt tgaggttgca
       61 gatagaactg acgaagtcag taacatatac ctacggcaag gcgacgttga cgtggtttga
      121 agagattttc gaagagtatt agaaaatgcc gataagggtc tgcataccaa ggctggtgag
      181 gatgatggca atccagcaga cggctccgag aacaatggat tttccactgg atttgaccat
      241 agcgaccaga ttagttttga gaccgatggc actcatggcc atgataatga ggaatttaga
      301 gagttgtttg agaggggtaa agaaactact agacacaccg agagaggtca gaagggtggt
      361 taggagcgat gcaaggatga agtgaaggat aaaaagtggg aagacttttt tcagttgtaa
      421 gccttgctta tttttttgct cgcgactttg ccagtaggag agaaagagag tgatggggat
      481 gatagctagg gttcgcgtga gtttgacaat ggttgcggat tcgagggtat tggtctggta
      541 gagactgtcc caagcgctag ctgtggcggt tacagaggaa gtatcattga ccgcagttcc
      601 tgcaaagagg gcgaagccgt cactggatag atgaagccag gtgccgaggg ttggaaagat
      661 gagcgcagcc aagacattga agaaaaagat aacggagatg gcttgggcta cttccttttc
      721 cttagcatgg ataacaggcg ctgtcgctgc aatggcagaa cccccacaga tagaagaacc
      781 tactccaatc aaggtagcca gttttgtatc cagggcaaag aagcgctgga agaggtaggc
      841 aacaatcaag gctattgaaa tggtggaaag gatgacaggg agtgaagatt gcccaactgc
      901 gaagacttga gagatattga gaccaaaacc aagcaagata acggcatact ggagcaattt
      961 cttggaacta aaggtcaatc caacatccag ttgtttataa gacgagagaa agggatgtag
     1021 gagcatgccc ataaaaatcg caaaaacggg cgcgccaatc acagggaaga atcctcctaa
     1081 gtaccaagat acgatagaaa tgagaaggca gaccaagatg cctgctccat tttttgatag
     1141 aaatgacata aaaacctcca aatagaatct gttaccatta tagacctgta aacaggaaaa
     1201 gtaaaataga aagtggaaag ctattctcta atgtattttt gcggtcgggg ggcttttgta
     1261 gtataataga gatatgtttt gaaagtagga ggtatctatg gacttaacta agcgctttaa
     1321 taaacagtta gataaaattc aagtttcgtt gattcgtcag tttgaccagg ctatttcgga
     1381 gattcctggg gtcttgcgtt tgaccttagg ggaacctgat tttacaacgc cagaccatgt
     1441 caaggaggcg gccaagcgag cgattgatca gaaccaatcc tactatacag ggatgagtgg
     1501 tctgctgact ctacgtcagg cggccagtga ttttgttaag gaaaagtacc aactggacta
     1561 tgctcctgaa aatgaaatct tggttacaat tggggcgaca gaggctttat ctgcgacttt
     1621 gacggctatt ttggaagagg gagacaaggt acttttgcca gctcctgctt atccaggcta
     1681 tgaaccgatt gttaacttag ttggggcaga aattgttgag attgatacga ctgaaaatgg
     1741 ttttgtcttg actcctgaga tgttggagaa ggccattttg gagcagggtg ataagctcaa
     1801 ggcggttatt ctcaactatc cagccaatcc gacaggaatt acctacagtc gagagcagtt
     1861 agaggccttg gcagctgttt tacgcaagta cgaagttttt gttgtctgtg atgaggttta
     1921 ctcagaattg acctacacag gcgaagccca tgtgtctcta ggaacgatgt tgagagacca
     1981 ggctattatt atcaatggtt tgtctaaatc gcatgccatg acaggttggc gtttggggct
     2041 gattttcgct cctgcgacct tcacagccca gttaatcaag agtcaccagt acttggtcac
     2101 tgccgcaaat accatggcgc aacatgctgc ggtagaagcc ttgacggctg gtaaaaacga
     2161 tgcggagccc atgaagaagg aatatatcca acgtcgggac tatatcatcg aaaaaatgac
     2221 tgctcttggt tttgagatta tcaaaccaga cggtgccttc tatatttttg ctaaaattcc
     2281 agcgggctac aatcaagact cctttgcttt tctgaaggat tttgctcaga agaaggccgt
     2341 tgcctttatc cctggtgcag cctttggacg ttacggggaa ggctacgtcc gcctatctta
     2401 tgcagccagc atggagacta tcaaagaagc catgaaacga cttgaggagt acatgagaga
     2461 agcatgattc agtctatcac gagtcaaggc ttggtgcttt acaatcgcaa ttttcgtgag
     2521 gatgacaagc tcgtcaaaat ttttacagag caggttggca aacgcatgtt ttttgtcaaa
     2581 cacgctggtc agtctaagct ggcgcctgtt attcagccct tggtgctggc acgatttctc
     2641 ttgcgaatca atgatgacgg actcagttac atcgaagact atcatgaggt catgactttt
     2701 cccaagatta atagtgacct ctttgtcatg gcctatgcga cctatgtggc agctcttgca
     2761 gatgctagtt tgcaggacaa tcagcaggat gctcccttgt ttgctttttt gcaaaagact
     2821 ttggagttga tggaagcagg cttggattat caggttttga ccaatatttt tgaaattcaa
     2881 attttgactc gatttggaat cagcctcaat tttaatgagt gtgtcttctg ccatcgggtt
     2941 ggtcaggctt ttgacttttc tttcaaatat ggagcctgcc tctgtccaga gcattatcat
     3001 gaggataaga gacgttgtca tctcaatccc aatatcccct atctgctcaa tcaatttcaa
     3061 gctattgatt ttgagacttt ggagaccatt tcgctcaagc ctggaatcaa gcaagagcta
     3121 cgccaattta tggatcaatt atatgaagag tacgttggga ttcacctaaa atcaaagaaa
     3181 tttattgatt ccctagcaga ctggggacaa ttactaaaag aggaaaagaa atgaaaaaaa
     3241 tcgcagtaga tgccatgggg ggcgattacg cacctcaggc cattgttgag ggtgtcaatc
     3301 aagccctatc tgacttttca gatatcgagg ttcaacttta cggagatgaa gctaaaatca
     3361 agccctatct gacagcgaca gagcgcgtca gcattatcca tacggatgag aagattgatt
     3421 cggatgatga acctacgaga gctattagga ataagaaaaa tgccagtatg gtattggcag
     3481 ccaaggctgt caaagatggt gaagcagacg ctgtcctttc ggctgggaat acaggtgcct
     3541 tgttggcagc aggattcttc atcgtgggtc gtatcaagaa tatcgaccgt cctggactca
     3601 tgtctacctt gcctaccgtt gatggaaaag gttttgacat gctagacctt ggtgccaatg
     3661 cagaaaatac agcccagcac ctccatcaat atgcggttct aggttccttc tatgctaaaa
     3721 atgtccgtgg cattgcgcaa ccacgcgttg gtttgctcaa caacggaaca gagagtagca
     3781 agggcgaccc gcttcgtaag gaaacttatg aattactggc ggctgatgaa agtttgaact
     3841 ttatcggaaa cgtggaaggg cgtgatttga tgaatggcgt tgcagatgtt gttgtggcag
     3901 atggtttcac gggaaacgct gtgctcaaat ccatcgaagg gacagctatg ggaatcatgg
     3961 gcttgctcaa gacagctatt acaggtggtg gtcttcgagc gaaactaggt gccctccttc
     4021 tcaaggacag cctcagtggt ttgaaaaaac agctcaatta ttcagatgtt ggtggagcgg
     4081 tcttgtttgg tgttaaggca cctgttgtca agactcatgg ctcaagcgat gccaaggctg
     4141 tttatagtac gattcgtcag atccgtacca tgctagaaac agacgtggtt gcccagactg
     4201 cgcgtgaatt ttcaggagaa taaaagagat gacagaaaaa gaaatttttg accgtattgt
     4261 gaccattatc caagagcgac agggagagga ctttgtcgtg acagaatcct tgagtctgaa
     4321 agacgatttg gatgcggatt ctgttgactt gatggagttt atcttgactc tggaagatga
     4381 atttagtatc gaaatcagcg atgaggaaat tgaccaactc caaagtgtag gagatgtggt
     4441 taaaatcatt caaggaaaat agcaatcgga gttccaagtc aacggaagta gatggttttt
     4501 agaaatgaga aatatcggac aagctggtaa aatcttggct gacagtggtt atcaagggct
     4561 catgaagata tatcctcaag cacaaacttc cacgtaaatc cagcaaactc aagccgctaa
     4621 cagttgaaga taaagcctgt aatcatgcgc tatctaagga gagaagcaag gttgagaata
     4681 tctttgccaa agtaaaaacg tttaaaatgt tttcaacaac ctatcgaaat catcgtaaac
     4741 gcttcggatt acgaatgaat ttgattgctg gtattatcaa tcatgaacta ggattctagt
     4801 tttgcaggaa gtctaatagt aaaaagtgat tagaaaacat cttttttaaa aatagagatg
     4861 attttgaaac aaaaaagcta attcaagacg tttcgattcc aattcaagat ttggatgaaa
     4921 aaaattaata gatactgtta tactaaactt gtcaagtttg taacaagaca aatattaaaa
     4981 ataaaaaaga ggtattcgtt atgaatacaa aaaagatgtc acaatttgaa attatggata
     5041 ctgagatgct tgcttgcgtt gaaggtggcg gatgcaattg gggagatttt gccaaagcag
     5101 gtgttggagg aggagcagta cgaggtcttc agctaggaat taaaacaaga acatggcaag
     5161 gtgcagcaac tggtgctgcg ggaggagcta tacttggagg tgtggcctat gcagcgacat
     5221 gttggtggta attatggatt ttaaaagttt tattattggt ttagtagttg gtatatttgg
     5281 tccttatatg gatgatttaa ttagaaaaaa atttttaaag tcttcggaga agaaaacaga
     5341 aaaatctgtt aaaaaataat caaaactata aatgatgaat ctgaatcaaa attattttgc
     5401 gcatgtaaag aggagtctta tagtaacgag tcaaaaaagg agtaactatg aatcgtaatt
     5461 tagaacggtg ttatctattc tgactaggaa tagatcatac cagaggtagc ttagaaatag
     5521 cagggacatt agaaattgaa gtaataaata ggatgtcgta agtgttacta tcaatgattt
     5581 atttgtttca agcttgccta gggtgacagt aaaaaatcaa tttcctttca atagcatatt
     5641 tttagtgggc aggactcttg ttctgcctat ttttttatcc aaaaagtgca gttgggaggg
     5701 agataggctc atttgggaag gaagtccagt ttttgtttag tgattggggt aagatagttg
     5761 ttatcagatg agtttatact cttcgaaaat caaattcaaa ccacgtcaac gtcgccttgc
     5821 cgtatatatg tgactgactt cgtcagtcct atctacaacc tcaaaacagt gttttgagca
     5881 gcctgcggct agtttcctag tttgctcttt gattttcatt gagtattagg gaaaaggaga
     5941 tgaatatgaa atttgggaaa cgtcactatc gtccgcaagt ggatcagatg gactgcggtg
     6001 tagcttcatt agccatgatt tttggctact atggtagtta ttattttttg gctcacttgc
     6061 gagaattggc taagacgacc atggatggga cgacggcttt gggcttggtc aaggtggcag
     6121 aggagattgg ttttgagacg cgagccatta aggcggatat gacgcttttt gacttgccgg
     6181 atttgacttt tccttttgtt gcccatgtgc ttaaggaagg gaaattgctc cactactatg
     6241 tggtgactgg gcaggataag gatagcattc atattgccga tccagatccc ggggtgaagt
     6301 tgactaaact gccacgtgag cgttttgagg aagaatggac aggagtgact ctttttatgg
     6361 cacctagtcc agactataag ccttataagg aacaaaaaaa tggtctgctc tcttttatcc
     6421 ctatattagt gaagcagcgt ggcttgattg ctaatatcgt tttggcaaca ctcttggtaa
     6481 tcgggattaa cattgtgggt tcttattatc tgcagtctat cattgatacc tatgtgccag
     6541 atcagatgcg ttcgacacta gggattattt ctattgggct agtcatcgtc tacatcctcc
     6601 agcaaatctt gtcttacgct caggagtatc tcttgcttgt tttggggcaa cgcttgtcga
     6661 ttgacgtgat tttgtcctat atcaagcatg tttttcacct ccctatgtcc ttctttgcga
     6721 cacgcaggac aggggagatc gtgtctcgtt ttacagatgc taacagtatc atcgatgcgc
     6781 tggcttcgac catcctttcg attttcctag atgtgtcaac ggttgtcatt atttcccttg
     6841 ttctattttc acaaaatacc aatctctttt tcatgacttt attggcgctt cctatctaca
     6901 cagtgattat ctttgccttt atgaagccgt ttgaaaagat gaatcgggat accatggaag
     6961 ccaatgcggt tctgtcttct tctatcattg aggacatcaa cggtattgag actatcaagt
     7021 ccttgaccag tgaaagtcag cgttaccaaa aaattgacaa ggaatttgtg gattatctga
     7081 agaaatcctt tacctatagt cgagcagaga gtcagcaaaa ggctctgaaa aaggttgccc
     7141 atctcttgct taatgtcggc attctctgga tgggggctgt tctggtcatg gatggcaaga
     7201 tgagtttggg gcagttgatt acctataata ccttgctggt ttactttacc aatcctttgg
     7261 aaaatatcat caatctgcaa accaagcttc agacagcgca ggttgccaat aaccgtctaa
     7321 atgaagtgta tctagtagct tctgagtttg aggagaagaa aacagttgag gatttgagct
     7381 tgatgaaggg agatatgacc ttcaagcagg ttcattacaa gtatggctat ggtcgagacg
     7441 tcttgtcgga tatcaattta accgttcccc aagggtctaa ggtggctttt gtggggattt
     7501 cagggtcagg taagacgact ttggccaaga tgatggttaa tttttacgac ccaagtcaag
     7561 gggagattag tctgggtggt gtcaatctca atcagattga taaaaaagcc ctgcgccagt
     7621 acatcaacta tctgcctcaa cagccctatg tctttaacgg aacgattttg gagaatcttc
     7681 ttttgggagc caaggagggg acgacacagg aagatatctt acgggcggtc gaattggcag
     7741 agattcgaga ggatatcgag cgcatgccac tgaattacca gacagaattg acttcggatg
     7801 gggcagggat ttcaggtggt caacgtcaga gaatcgcttt ggcgcgtgct ctcttgacag
     7861 atgcgccggt cttgattttg gatgaggcga ctagcagttt ggatattttg acagagaagc
     7921 ggattgtcga taatctcatg gctttggaca agaccttgat tttcattgct caccgcttga
     7981 ctattgctga gcggacagag aaggtagttg tcttggatca gggcaagatt gtcgaagaag
     8041 gaaagcatgc tgatttgctt gcacagggtg gcttttacgc ccatttggtc aatagctaga
     8101 aagaggagag gatgaaacca gaatttttag aaagtgcgga gttttataat cgtcgttacc
     8161 ataatttttc cagtagtgtg attgtaccca tggcccttct gcttgtgttt ttacttggct
     8221 ttgcaactgt tgcagagaag gagatgagtt tgtccactag agctactgtc gaacctagtc
     8281 gtatccttgc aaatatccag tcaactagca acaatcgtat tcttgtcaat catttggaag
     8341 aaaataagct ggttaagaag ggggatcttt tggttcaata ccaagaaggg gcagagggtg
     8401 tccaagcgga gtcctatgcc agtcagttgg acatgctaaa ggatcaaaaa aagcaattgg
     8461 agtatctgca aaagagcctg caagaagggg agaaccactt tccagaggag gataagtttg
     8521 gctaccaagc cacctttcgc gactacatca gtcaagcagg cagtcttagg gctagtacat
     8581 cgcaacaaaa tgagaccatc gcgtcccaga atgcagcagc tagccaaacc caagccgaaa
     8641 tcggcaacct catcagtcaa acagaggcta aaattcgcga ttaccagaca gctaagtcag
     8701 ctattgaaac aggtgcttcc ttggccggtc agaatctagc ctactctctt taccagtcct
     8761 acaagtctca gggcgaggaa aatccccaaa ctaaggttca ggcagttgca caggttgaag
     8821 cacagatttc tcagttagaa tctagtcttg ctacttaccg tgtccagtat gcaggttcag
     8881 gtacccagca agcctatgcg tcagggttaa gcagtcaatt ggaatccctt aaatcccaac
     8941 acttggcaaa ggttggtcag gaattgaccc ttctagccca gaaaattttg gaggcagagt
     9001 caggtaagaa ggtacaggga aatcttttag acaaggggaa agttacggcg agtgaggatg
     9061 gggtgcttca tcttaatcct gagaccagtg attctagcat ggttgcagaa ggtgccctac
     9121 tagcccaact ttatccatct ttggaaagag aagggaaagc caaactcaca gcttatctaa
     9181 gttcaaaata tgtagcaaga atcaaggtcg gtgattctgt tcgctatact acgactcatg
     9241 atgccgggaa tcaacttttc ctagattcta ctattacaag tattgatgcg acagctacta
     9301 agactgagaa agggaatttc tttaaaatcg aggcggagac taatctaact tcggagcagg
     9361 ctgaaaaact taggtacggg gtggaaggcc gcttgcagat gattacgggc aagaaaagtt
     9421 acctacgtta ttatttggat caatttttga acaaagagta atgttcgtgt ttttagagtt
     9481 aaataatttt taaactgtga gaaagattct tcttgcagtt ttttctttac aatttttgaa
     9541 aaacatctac tatttattcg gttaaattct tgtgtttttt ggttttttgt ggtaaaatgt
     9601 gctcaagtaa tacgaaaggc gaactttaaa atgtcaaaac aattgatcta ttcgggaaaa
     9661 gctaaagata tctatacaac tgaggatgaa aatcttatta tttcaactta caaggaccag
     9721 gcgactgctt tcaacggtgt caagaaggag cagattgcag gtaagggagt cttgaataat
     9781 cagatctcat cttttatttt tgagaaatta aatgtggctg gtgtggcgac tcactttgtg
     9841 gagaaacttt cagacacgga acaactcaat aaaaaggtta agattattcc tttggaagtc
     9901 gtgctccgca actatactgc tggttccttt tcaaaacgtt ttggtgtgga tgagggaatc
     9961 gccttggaga ctccgattgt cgaattttac tacaaaaatg atgatttgga tgatccattt
    10021 atcaatgatg agcatgtgaa attcctacag attgcgggtg accagcagat tgcctacttg
    10081 aaggaagaaa cgcgtcgtat caatgaacta ttgaaagtct ggtttgctga gattgggctt
    10141 aaattgattg actttaagct agagttcggt tttgacaagg atggcaagat tatcttggca
    10201 gacgaatttt caccagataa ctgccgcttg tgggacgctg atggcaacca catggataag
    10261 gatgttttcc gtagaggatt gggagaacta accgacgttt atgagattgt ttgggaaaag
    10321 ttgcagggtt taaaataaca acctcaaggc tgtttgggaa tattgcaaga gctgaaataa
    10381 aggaataaga attgatggat aaacgtattt ttgttgaaaa aaaggctgat tttcaggtca
    10441 agtcagagag tttggttaga gagctccagc acaacttggg actgtcaagc ttgaaaagta
    10501 ttcgtattgt gcaagtatat gatgtatttg acttggttga ggacttgttt gcacctgcag
    10561 agaagcacat tttctctgag caggtaaccg accatgtttt agatgaagta tctgtgcagg
    10621 cggatcttgc taactatgct ttctttgcca ttgaaagtct accagggcag tttgaccagc
    10681 gtgcagcttc gtcacaggaa gccttgcttt tgttgggaag ttcgagtgac gtgacagtca
    10741 acacagccca actttacttg gtgaataaag atattgatgc gactgagttg aaagctgtca
    10801 aaaactacct gctcaatcca gttgattctc gtttcaagga tatcacgaca gggattgcca
    10861 agcaggagtt ttcagagtca gacaagacca ttccaaaatt gactttcttt gaaagctata
    10921 cagcagaaga ttttgctcgc tacaaggccg aacaagggat ggccatggaa gtggatgatt
    10981 tgctctttat ccaagactac tttaagtcaa tcgggcgcgt gccaactgag actgaactta
    11041 aggttttgga cacttactgg tctgaccact gccgtcatac gacttttgag acagagttga
    11101 aacacatcga cttttcagct tctaaatttc aaaagcaatt gcagtcaacc tatgacaagt
    11161 atattgccat gcgcgaggaa ttaggtcggt ctgaaaaacc acaaaccttg atggatatgg
    11221 cgactatttt cggtcgttat gagcgtgcta atggacgatt ggatgatatg gaagtctctg
    11281 acgaaatcaa tgcctgctca gttgaaattg aagtggacgt tgatggtgtc aaggaacctt
    11341 ggctcctcat gtttaaaaac gaaacccaca accatccaac agaaattgag ccatttggtg
    11401 gagcggctac ctgtattggt ggagctattc gtgatccgtt gtcaggccgt tcctatgttt
    11461 accaagccat gcgtatttca ggtgctggtg atattacagc accgatttcg gaaactcgcg
    11521 ctgggaaatt gccacaacaa gtcatttcta aaacagcagc tcatggttat tcttcatatg
    11581 gtaaccagat tgggcttgcc acaacctacg ttcgtgaata cttccaccca ggctttgtag
    11641 ctaaacgtat ggaacttggt gccgttgttg gtgcggctcc caagggcaat gttgtccgtg
    11701 aaaaacctga agcaggtgat gtgatcatcc ttctcggagg taaaacaggt cgtgatggtg
    11761 tcggtggtgc gacgggctct tctaaggttc aaacagttga gtctgtagag actgctggtg
    11821 ctgaggttca aaaaggaaat gccatcgaag aacgcaagat tcagcgcctc ttccgtaatg
    11881 gcaatgtcac tcgtctgatc aagaagtcca atgactttgg ggcaggcggt gtctgtgtgg
    11941 ctatcggtga attggcagac ggtcttgaaa tcgacctcaa caaggtgcct cttaaatacc
    12001 agggcttgaa tggtacagaa attgccatct ctgaatcaca agaacggatg gcggtcgtgg
    12061 ttcgtcctga agatgtggat accttcgttg ccgaatgtaa caaagaaaat attgatgctg
    12121 ttgtggtggc gacagtaact gaaaaaccaa atcttgtcat gcactggaat ggtgagacaa
    12181 tcgttgactt ggagcgtcgt ttccttgaca ccaatggtgt gcgcgtggtt gtcgatgcca
    12241 aagttgtgga caaggatgtc aaactcccag aagagcgtca aacatctgct gaaacactgg
    12301 aatcagatac ccttacggtt ctatctgacc tcaaccatgc aagtcaaaaa ggattacaga
    12361 ctatctttga ctgctctgtt ggacgctcaa cggttaatca cccacttggt ggtcgttacc
    12421 aactcacacc aactgaggca tctgtgcaga aattgccagt tcaacacggt gtgactcata
    12481 ctgcgtcggt cattgctcaa ggtttcaacc catatgtagc tgaatggtct ccataccacg
    12541 gtgctgctta tgcggttatc gaagcaactg ctcgtttggt ggctgctggt gccaactggt
    12601 ctaaggctcg tttctcttac caagaatatt tcgagcggat ggacaagcaa gcagagcgtt
    12661 ttggtcagcc agtagccgcc cttctaggct ctattgaagc acaaattcag cttggcttgc
    12721 catctatcgg tggtaaggac tccatgtctg gtacctttga agaattgacc gttccgccaa
    12781 ccttggttgc ctttggggtg acgacggcag atagccgtaa ggtgctctct ccagaattta
    12841 aagctgttgg ggaaaatatc tactacatcc caggtcaagc cctctctgca gagattgatt
    12901 ttgacttgat taagaaaaat tttgctcagt ttgaagcaag ccaagctgac cataaagtga
    12961 catctgcatc agctgtcaaa tacggtggtg tagttgaaag tttggctctt gctacctttg
    13021 gaaactatat tggtgcagag gtgaccttgc ctgaacttaa aacagctttg acagctcaat
    13081 taggcggctt tgtcttcac
//
