LOCUS       NC_013729              22568 bp    DNA     circular CON 20-MAR-2024
DEFINITION  Kribbella flavida DSM 17836, complete sequence.
ACCESSION   NC_013729
VERSION     NC_013729.1
KEYWORDS    RefSeq.
SOURCE      Kribbella flavida DSM 17836
  ORGANISM  Kribbella flavida DSM 17836
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 7579488)
  AUTHORS   Pukall,R., Lapidus,A., Glavina Del Rio,T., Copeland,A., Tice,H.,
            Cheng,J.F., Lucas,S., Chen,F., Nolan,M., Labutti,K., Pati,A.,
            Ivanova,N., Mavromatis,K., Mikhailova,N., Pitluck,S., Bruce,D.,
            Goodwin,L., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Chen,A.,
            Palaniappan,K., Chain,P., Rohde,M., Goker,M., Bristow,J.,
            Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., Klenk,H.P.
            and Brettin,T.
  TITLE     Complete genome sequence of Kribbella flavida type strain (IFO
            14399)
  JOURNAL   Stand Genomic Sci 2 (2), 186-193 (2010)
   PUBMED   21304701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7579488)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Saunders,E., Brettin,T., Detter,J.C.,
            Han,C., Larimer,F., Land,M., Hauser,L., Markowitz,V., Cheng,J.-F.,
            Hugenholtz,P., Woyke,T., Wu,D., Pukall,R., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     The complete genome of Kribbella flavida DSM 17836
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7579488)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Saunders,E., Brettin,T., Detter,J.C.,
            Han,C., Larimer,F., Land,M., Hauser,L., Markowitz,V., Cheng,J.-F.,
            Hugenholtz,P., Woyke,T., Wu,D., Pukall,R., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2009) US DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000024345.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 02:06:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,131
            CDSs (total)                      :: 7,069
            Genes (coding)                    :: 7,033
            CDSs (with protein)               :: 7,033
            Genes (RNA)                       :: 62
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 36
            CDSs (without protein)            :: 36
            Pseudo Genes (ambiguous residues) :: 0 of 36
            Pseudo Genes (frameshifted)       :: 8 of 36
            Pseudo Genes (incomplete)         :: 29 of 36
            Pseudo Genes (internal stop)      :: 4 of 36
            Pseudo Genes (multiple problems)  :: 4 of 36
            ##Genome-Annotation-Data-END##
            ##Metadata-START##
            Organism Display Name             :: Kribbella flavida DSM 17836
            Culture Collection ID :: DSM 17836, JCM 10339, KCTC 9580, NBRC 14399
            GOLD Stamp ID                     :: Gi02235
            Funding Program                   :: DOE-GEBA 2007
            Gene Calling Method               :: GeneMark
            Isolation Site                    :: Soil from China
            Isolation Country                 :: China
            Oxygen Requirement                :: Aerobe
            Cell Shape                        :: Rod-shaped
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28C
            Gram Staining                     :: gram+
            Biotic Relationship               :: Free living
            Diseases                          :: None
            Habitat                           :: Soil
            ##Metadata-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:11:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6950627
            Orig. end                         :: 6973195
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP001736.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4082793
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Jonathan A. Eisen (jaeisen@ucdavis.edu)
            David Bruce (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Finishing done by JGI-LANL
            Annotation by JGI-ORNL and JGI-PGF
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22568
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="13"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22568
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22568
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12568](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12568
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(168..177)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(1801..1816)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.44"
                     /tool="antismash"
     misc_feature    1879..1894
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.35"
                     /tool="antismash"
     misc_feature    complement(2735..2749)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.18"
                     /tool="antismash"
     misc_feature    complement(2818..2833)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            complement(2871..3491)
                     /locus_tag="KFLA_RS32250"
                     /old_locus_tag="Kfla_6492"
     CDS             complement(2871..3491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391586.1"
                     /locus_tag="KFLA_RS32250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6492"
                     /product="hypothetical protein"
                     /protein_id="WP_012924041.1"
                     /transl_table=11
                     /translation="MSEPLEPASAAEAARELAKVLLEQADALDLHDLRATTAIENVRVQ
                     SRVLADAVHERGWGDIFLGIDSYDPDELDDVPLGPDDFDDPADYRELVEGVADLDEPLV
                     PENGMRLSYQARYDFVVTDPEAFIAYVRSRADEAVIQGNDDEIDDIDDARSAFELLGYL
                     DGLGSKDYDTVGLSPAGGEESHKVVEFSLWDMDPTRRDDTYPY"
     gene            complement(3484..5451)
                     /locus_tag="KFLA_RS32255"
                     /old_locus_tag="Kfla_6493"
     CDS             complement(3484..5451)
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_function="GO:0003997 - acyl-CoA oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391585.1"
                     /locus_tag="KFLA_RS32255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6493"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_012924042.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.2e-08, bitscore:
                     32.9, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2e-16, bitscore:
                     58.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1e-12, bitscore:
                     47.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLREYLDGPHKAARDVVRDGLATHAGLLDAGLRLSRDEYRDQV
                     LATLREVAAQGHPVRGFPKEYGGQGDLGGFIAGFETLAFGDLSLMVKAGVQFGLFAGAI
                     LHLGTERHHERYLADALTGDLLGCFAMTETGHGSNVQALETTATYDPATGEFVVHTPTA
                     SARKDYIGNAARHGRLAAVFAQLVVGGQTLGVHCLLVPIRTDDGQPVTGVTISDCGPKL
                     GLNGVDNGRIVFDQVRVPREALLDRYAQVDADGTYRSEIENPDRRFFTMLGTLVQGRVS
                     VGGAAINASKVALTIAVRYAEQRRQFGAPGSPEEALLLDYRMHQRRLLPLLARTYALHF
                     AQAELVDEFARIFGADTATGQDGGSAPDGGSRSDEHDRRALEAQAAGTKAVGTWHATET
                     IQLCREACGGAGYLAENRLSTLKADTDVFTTFEGDNTVLLQLVAKGLLTDYRESFGKLD
                     PLGTARFVAGQAVEIAVEKTALRGLIERLRDAVPNRSDAGDPDAGLRDDDYHSGLLRFR
                     EQHMLAGVARRLRAGIDAGDEAFEVFNRCQDHVIAAGRAHVERVVLEAFQRAVHAAPEG
                     ETRDRLKELYDLHALTTIENDRAWFMEHGRLSGPRSKAITALVNDLCGRVRPHASSLVD
                     AFGVPGAAVDVPMVVRSLHE"
     gene            5535..5930
                     /locus_tag="KFLA_RS32260"
                     /old_locus_tag="Kfla_6494"
     CDS             5535..5930
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156143.1"
                     /locus_tag="KFLA_RS32260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6494"
                     /product="TOBE domain-containing protein"
                     /protein_id="WP_041290715.1"
                     /transl_table=11
                     /translation="MPILRISEAAALLGVSDDTVRRWIDQKRLPATEQGGRMAVDGREL
                     AAFAQRLAESPEPGTTTAASARNRMRGIVTRVVKDGVMAQVELQTGPFRVVSLMSREAA
                     DELGLEPGVVAVASIKSTHVVVEIPEA"
     gene            5976..6752
                     /gene="modA"
                     /locus_tag="KFLA_RS32265"
                     /old_locus_tag="Kfla_6495"
     CDS             5976..6752
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015412 - ABC-type molybdate transporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0030973 - molybdate ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015689 - molybdate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="modA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391583.1"
                     /locus_tag="KFLA_RS32265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6495"
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_049797467.1"
                     /transl_table=11
                     /translation="MKAGRRVLAGVVAVAGLLASAACGSGDSPAASANGSGVDGTVTVF
                     AAASLTGSFTRLGKDFEAAHPGVEVVFNFAGSSALAQQINQGAPADVFASAAPKNLDQV
                     TGKGTPTTFVRNRLEIAVPKGNPGKVTGLRDFADPGRKIALCAEQVPCGAAARKVFAAA
                     RITPEPDSLEQDVKAALTKVGLGEVDAALVYRTDVLAAKDKVEGIEFPEAAQAVNDYPI
                     ATLTTAPNAEGAQAFVDFVLSPAGKKVLAEAGFDVP"
     gene            6749..7561
                     /gene="modB"
                     /locus_tag="KFLA_RS32270"
                     /old_locus_tag="Kfla_6496"
     CDS             6749..7561
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015412 - ABC-type molybdate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015689 - molybdate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="modB"
                     /gene_functions="transport (smcogs) SMCOG1214:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020575943.1"
                     /locus_tag="KFLA_RS32270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6496"
                     /product="molybdate ABC transporter permease subunit"
                     /protein_id="WP_012924045.1"
                     /transl_table=11
                     /translation="MSTRGRRRRTGGRLPVVLLLPALLGLAFLLVPLIGLLLEAPWSTL
                     PSRLFSAEVGQALRLSLICASAATVLCLLFGIPLAWLLARADIPGRGVLRALVTVPLVL
                     PPVVGGVALLLVLGRRGLIGERLDLWFGLTLPFTTAGVIVAEAFVAMPFLVISVEGALR
                     AADPRYEEAAATLGAGRWLTFRRVTLPSIAPGVVAGAVLCWARALGEFGATITFAGNLP
                     GRTTTMPLAVYLALETDPDVAVVLSLVLLLVSVAVLACLRERWIGGLR"
     gene            7558..8625
                     /locus_tag="KFLA_RS32275"
                     /old_locus_tag="Kfla_6497"
     CDS             7558..8625
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391581.1"
                     /locus_tag="KFLA_RS32275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6497"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_012924046.1"
                     /transl_table=11
                     /translation="MTLHADLHVRRTGFELAMELSVAPGEVVALLGPNGAGKTTALRAL
                     AGLLPLDDGRITLDDDLWDEPPGVFRPADRRPIGVVFQDYLLFDHMSALENVAFGLRAR
                     GVGKHTARAEALRWLSTVGLAEHAASRPRSLSGGQAQRVALVRALATEPELLLLDEPLA
                     ALDAGTTLHVRAELGQHLSRYEGRTLLVTHDPLDAMVLADRLVIVENGRVVQEGAPTEI
                     ARRPRTDYVAHLVGLNLYRGTAEGTTVHLAAGGTVTTATPATGPVHVSFPPSAVSLYPD
                     RPSGSPRNTWPVVVTGIEQHAHTVRVRLSPAPDSSAPTDLLTDVTTAAVAELHLTPGRH
                     LWATLKATETQTYPS"
     gene            8801..9757
                     /locus_tag="KFLA_RS32280"
                     /old_locus_tag="Kfla_6498"
     CDS             8801..9757
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391580.1"
                     /locus_tag="KFLA_RS32280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6498"
                     /product="hypothetical protein"
                     /protein_id="WP_237706644.1"
                     /transl_table=11
                     /translation="MIEPSVEWREVVHDDEAERHRRQAERFVELQARRSGEFGAGRASH
                     RQQVAALRAVLTVPSDLPEYAQQGLFRVPDTYDAWVRLSNGGFNRAPDAVPDVHGFAVK
                     VFGTSGPAALGGEAVCQDLVLINHERLSSPTSEEFTTLVTTAAGTSGQVLRAVARQPSL
                     FPRLRAASAALKTPFSGFATQDFFSAAPIAFGPYAVRVKLAARADQVDPRASGDWAADV
                     HARLADGPLHYDLQVQFFVDEQRTPIEDASVVWDTPCLTVARLTVPRQRPDPALADEIE
                     RASFDPWTAKAEHRPLGEVMRARRIAYAASRQNRDAQ"
     misc_feature    8954..8956
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9818..9834
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
     gene            10001..12568
                     /gene="lanKC"
                     /locus_tag="KFLA_RS32285"
                     /old_locus_tag="Kfla_6499"
     CDS             10001..12568
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391579.1"
                     /locus_tag="KFLA_RS32285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6499"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_012924048.1"
                     /sec_met_domain="micKC (E-value: 5.1e-242, bitscore: 804.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.6e-16, bitscore: 58.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 0.00013, bitscore:
                     19.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESYELYCLADRLFYDTPANRGAEHPDFAQASRPVPAGWQHVAGE
                     MWMHYAPDGLRLPAQGWKVHVSAGLADAERVLDAVWDYCVPRGIAFKFLRNEPVLVMVN
                     SKSAPRGSSGKLVTIYPTDEAQLELVLKELDDLLHGVRGPYILSDLRYAEGPLFVRYGA
                     FVSRYTLDAAGDRVLALEDDHGRLVPDHRSPTFSVPPWVRLPSFLASHLEARNAVTTND
                     LAYTIDGVIQFSNGGGVYLGHHNETQDRVVLKEGRPLAGLDMSGRDAVARIGHERDILQ
                     RLDGLGVVPKVHDYFTLGDHHFLVQEFVDANPLQRELVRRYPLTRPDASAADLAEYAEW
                     ATRMVTAVQQAVGQLHGRGVVFCDLHPDNVLLSTGDRLVLIDFEVATLAAEQARSALAH
                     PGYAAPGDRQGTDVDLYALACITLGLFAPQATMLLNLHPGKAFQLAGMIAETFPVPRAT
                     LDAAVRTIVGPELTEDPEMAALPLPGRAGWTDVRAALTTAIVASATPERDDRLFPGDIA
                     QFRPGGGINLATGAAGVLYALAKTGAGRFPEYEDWLREHALTTETGPGLYDGLHGVAHV
                     LGELGHRQDALDAIDRTLADDLGSRELGLHSGLAGIGLNLLHFAATEPGLQGKAVRILD
                     LVADRLGDVTDVPELSGEGKPRAGLMYGSSGPALLFLTAYERTGDTGLLDLAETALRQD
                     LRRCIPTPDGTLQVNQGWRTLPYLEEGSAGIALVLSRYLQHRPDEKLATQLAALRLVTH
                     CAYYVQPGLLMGRAGLLLTAAELGDSTDDLVRGLGWHALPYEGGLIFPGNQLLRLSTDL
                     ATGSAGVLLALGTALHERPVSLPFLGPPQWSESPSRRLPPKEV"
     gene            12573..12710
                     /locus_tag="KFLA_RS37165"
                     /old_locus_tag="Kfla_6500"
     CDS             12573..12710
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391578.1"
                     /locus_tag="KFLA_RS37165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6500"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_012924049.1"
                     /transl_table=11
                     /translation="MALLDLQGLETPGYGHGGHHHGGSTLTVLGCGSQRPSNLSLLLCH
                     "
     CDS_motif       12573..12632
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGLETPGYGHGGHH"
                     /locus_tag="KFLA_RS37165_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12633..12710
                     /prepeptide="core"
                     /locus_tag="KFLA_RS37165_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="4.60"
                     /molecular_weight="2442.8"
                     /monoisotopic_mass="2441.3"
                     /core_sequence="HGGSTLTVLGCGSQRPSNLSLLLCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGLETPGYGHGGHH"
                     /leader_location="[12572:12632](+)"
                     /alternative_weights="2460.8"
                     /alternative_weights="2478.8"
                     /alternative_weights="2496.9"
                     /alternative_weights="2514.9"
     gene            12836..14809
                     /locus_tag="KFLA_RS32290"
                     /old_locus_tag="Kfla_6501"
     CDS             12836..14809
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391577.1"
                     /locus_tag="KFLA_RS32290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6501"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_012924050.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 7.7e-51, bitscore:
                     171.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYPPAERLPLVEQVHGQAVADPYRWLEDATSPETLRWQAAQDEL
                     WLNHAATLPSRYHFRNRVRALSAVGSVSTPVWRGDRCFVLRREPRQDHPVLMVDDTVLL
                     DPVQLDPSGLTTLDSWQPSPDGSRLAFQVSRGGDERSVLHVLDVATGEVVDGPIDGCRY
                     SPIAWLPDGKSFYYVRLRRVLLHHIGSADDQQVFTDEASYGLDLSADGRWLAVSAARGR
                     GNDLWLADLGNDAPPQVLQAGADAVTVVSVGGDGRLYVVTTKDAPTGRICIGDPENPLI
                     WHDYVAADPDAPLSSLAVLDKVVLVGRSRAGIGEIIVHDLVTGRRLGEIPLPGKGSVGS
                     LTTRPEGGHQAWFSYTDSVTPAAVYCYDATTGETSLWSEPPGAAPVAAATATPVSFRSG
                     DGTELDMLVIAGPGDGMPRPTILYGYGGFGQSLTPAYSAFTLAWVEAGGVFVTATLRGG
                     GERGDAWHRAGMLDQKQNVIDDFLAAAEQLIADGWTTSDQLGLCGESNGGLLVGAAITQ
                     RPELFAAAVCSAPLLDMVRYERSGLGPQWVPEFGSASDPQQLKTLLSYSPYHHVTPGIR
                     YPAVLFTAFGNDTRVDPLHARKTCAALQHATSGPPDSRPVLLRLDPDAGHSAGSTSQGI
                     ALAADMLAFLAGQLRLTPRSDP"
     gene            14806..16461
                     /locus_tag="KFLA_RS32295"
                     /old_locus_tag="Kfla_6502"
     CDS             14806..16461
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391576.1"
                     /locus_tag="KFLA_RS32295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6502"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_012924051.1"
                     /transl_table=11
                     /translation="MSLTFAAVARHGRGWLPVIAVTSVAGSCVSLALPSVLGRSVDSIV
                     AGHGYHQWLTIAVALVATGIICALVDVFAGTACVAGTTAWLRHGLVRRVVRGGPEGSRG
                     FDTGDLVSRVSGNAVDAAQAGPALISAFAAVLPPAGSLVLLALIDPWLAAAFFGGVALV
                     IAVLWIFARRTARISLAYQETQGRISGLLTESLTGIRTILAAGTVGREERRILSLLPEL
                     HKHGLLTWRVLARSGAQAAVVGPLVLVAVLAVGGLQLVEGRITAGELFAAGQYAVLGAG
                     LGSLTGVIGEIARARAGVSRAAEVFAIESVPHGTLPLPPGPGRLRFDGVSVRSGDTVLL
                     DEIQLDLPGGATVAVIGPSGAGKSVLAALAARLRDPSTGQVLLDGVPLQAVQRHALRRA
                     VGCAFERPTLVGSTIGDAISHRANSTVRTLAAARATHAHDFVSRLPQGYRTPLPEAPMS
                     GGERQRLGLARAWPADRLLVLDDATSSLDTATEMQISRTLTDDRHRRTRLIVTHRPATA
                     ARADLVVWMERGRVRAVGHHSELWRHPDYREVFG"
     gene            16458..18164
                     /locus_tag="KFLA_RS32300"
                     /old_locus_tag="Kfla_6503"
     CDS             16458..18164
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391575.1"
                     /locus_tag="KFLA_RS32300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6503"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_012924052.1"
                     /transl_table=11
                     /translation="MKRELRYGVAALRNRSALKLALWSVPEILPTALYGIAVARATDSF
                     LAGHAWQGIAWLGGLVATACIGAAGSYQVYGRLGELVEPLRDDLVRRVVGGALRTGDDA
                     AVARLNRQVEIVRDTFAGLVLVVRSFAVTLFGVLAGLLSLAPAIAVLVVPPFLLGFAAS
                     LAVLGLAADRVRASLQADEDLAAAAGMTFSGVRDITATGSEEFVEHFAGRPIEAQAAAE
                     RSLAKVAALRTLCFAVGGWAPLLILLAAGPWLVGRGVSTGTLLGGLTYVLIGLQPALST
                     VMGALGDSGLRYVVTLGRILSLQPPPERPLRGSQQSGAAIEPAGHQVRARGLTFAYGPA
                     AEPVLERLDLVVAEGEHLAVVGPSGIGKSTLAGLICGLLTPTEGRLLLGGVPPSEVTAE
                     RLAGTRVLIPQEAYVFSGTVRENLDYLLPDASTSEVEQAVDAVGSAALVRRLGGLDATL
                     RPGDLSAGERQLIALTRAYLSPAPLVVLDEATCFLDPEAERRAEQAFAQRGGTLIVIAH
                     RISSALRAQQILVLDGNRATLGTHQTLLRASPLYRELLGHWQPEDRIQPAS"
     gene            complement(18227..18826)
                     /locus_tag="KFLA_RS32305"
                     /old_locus_tag="Kfla_6504"
     CDS             complement(18227..18826)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012920101.1"
                     /locus_tag="KFLA_RS32305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6504"
                     /product="response regulator transcription factor"
                     /protein_id="WP_012924053.1"
                     /transl_table=11
                     /translation="MIRVVLGHRGTLVRGALAAVLSRESDLDVLAALDRSDDVLAAVRL
                     RPQVVVLDPQLPGKVGIEELCRRLTGRGVLVLVDHEAIAATSMALVKQAPRVGLIATDA
                     TTDQLVEAVRDVAKGLPVVDVRLAVAALRAGDNPLTDRECEVLRQVTTGATAQEIARTL
                     SLSAGTVRNYLSRILTKTGARSRIEAIRKAQDAGWI"
     misc_feature    19043..19056
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.22"
                     /tool="antismash"
     misc_feature    complement(19097..19112)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     gene            19381..20079
                     /locus_tag="KFLA_RS32310"
                     /old_locus_tag="Kfla_6505"
     CDS             19381..20079
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391573.1"
                     /locus_tag="KFLA_RS32310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6505"
                     /product="transglycosylase family protein"
                     /protein_id="WP_012924054.1"
                     /transl_table=11
                     /translation="MSKARHARPRRSTRRIVRTLSIAGLGAGITAVGAGAAFATDYTVK
                     SGDTLSEIAQANGTDWHQLAELNGLDNPDLILIGQTLKLDGVNKAAVTERRSTAKTERK
                     TERRSERKVEARSERKTERKSERKSERKSERKARTSRSESTRGGNGGSVSMSAAWRKVA
                     QCESGGNPRAVNPTGKYHGLFQFDRQTWRSVGGSGLPSNASAAEQLMRAKKLYSQRGAS
                     PWPSCGRFLR"
     gene            complement(20152..20799)
                     /locus_tag="KFLA_RS32315"
                     /old_locus_tag="Kfla_6506"
     CDS             complement(20152..20799)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391572.1"
                     /locus_tag="KFLA_RS32315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6506"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_012924055.1"
                     /transl_table=11
                     /translation="MLVTSRSYAEYEAMFDLSDLPESVLDCCAGGAGFTAEAAARGVDA
                     VAVDPAYELPAAELVDTVRRSLPATSGIVDEHAGNFVWHWYGSPERKDELRLDAADRFL
                     TDVAVAPERYVPGSLPELPFPDRRFELVLSSHLLFTWADKYDQDWHLAALRELVRVARS
                     EVRVFPLVKQGAGEPVEYLPELLEQLDGVQAEIRRVPYEFQAGANRMLVLTH"
     gene            complement(20804..21445)
                     /locus_tag="KFLA_RS32320"
                     /old_locus_tag="Kfla_6507"
     CDS             complement(20804..21445)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391571.1"
                     /locus_tag="KFLA_RS32320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6507"
                     /product="Pr6Pr family membrane protein"
                     /protein_id="WP_012924056.1"
                     /transl_table=11
                     /translation="MTKFGAGRLWFAVTAAVVAIGIIVQLVVTATTTEGFFPDNPDRVL
                     NVFAFFTIQSNLLLGGTTLLLALGAASDSTVFRTLRLNGVLCIAVTGIVYHVALAGLDE
                     LSGAAALTNFLLHTATPVLGVVGWLLFGPRDRTDREIVGWSLAFPLLWLAFTLVRGELV
                     GFYPYPFVDVGELGYAQVLLNCLLVALLFLALAFGATLLDRRLTRTTVER"
     gene            complement(21501..22055)
                     /locus_tag="KFLA_RS32325"
                     /old_locus_tag="Kfla_6508"
     CDS             complement(21501..22055)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391570.1"
                     /locus_tag="KFLA_RS32325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_6508"
                     /product="2TM domain-containing protein"
                     /protein_id="WP_012924057.1"
                     /transl_table=11
                     /translation="MLLAVIAACEIGFWVLLAAGLTTRYLFRLPKLGMALLVMVPLVDV
                     VMLVASVIDIRTGGEPSFKHSLAAIFIGVSVGFGHRTLQWADGWAAHKFAGGPRPYKPR
                     KGTREKARWERQGWYRHLTSYAVACAIMIGLGLLSGEGYDALLGPAWTWTIVLVIDGFI
                     SFSYGDDVDEDADSKQDRVEA"
     misc_feature    22069..22078
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     misc_feature    22070..22083
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.13"
                     /tool="antismash"
     misc_feature    22075..22092
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
ORIGIN
        1 gccacgaact gcgcgtcgga catcaccgcg aaccgccagt cccggccgtc caccgcgcgc
       61 gccgtctgca ccagaccgtc ccggaccggc ggtgccgccg gagcggtcac cgtcggggcc
      121 gacttgacgt aggcgttgtc gatcacgacc tcaccggtgt actgcgcggc cgccttcgtc
      181 tccagcgtgt agacccggcg caggctcacc ggttgcggaa gtccctcggg gaccggcagc
      241 tcgacggtct gccagccgtt ccaggtgatg tacgggccgt acagggtcgt cgagcgtcca
      301 gtggcgtcga cgacctgcag cgcggtccac tcgcccttgc cgtgaccgtg gatcgagacc
      361 ccgaaggcgc gggactgccc ggtgccgccg agcggccgcg gcgagatcgc gatggcgttc
      421 cgggtcagcg tcgactggct gaagtcgtag ctgagcttga gtccgggacc gttctcacct
      481 tcggccacct tgcgcaccga caccgcggcg cgggccgacc cggcggtcca ctgctcggcc
      541 tggtcgaagg tgtcgaggat gcgcttctcg acgccgaccg acaccgcgac cgacgtctcg
      601 agggcaccga tccgggcggt gatcacgccg gccccggact cctgcttcgg cgtcagctcg
      661 aaccggccgt cgcgggtcgg cacgacctgg aacagggtct ggtcgtagga cagccggacg
      721 tcggccggct cgaccggcgc ggagttgccg tgggcatcga acccgaccag accgaagctg
      781 ccggtggtgg tcaggttcag cgtcgcgctc gtcggcgtga cccgctgcac cggcccgagc
      841 acctccagct ccgtgctgcc gcgtccgccg gacgtcgtcg cacgcaccgt cgcccgtccc
      901 ggggtgaggg cccggaacac cccgtcgcgc acgatgccgt gcgaggcgga ccagtggatc
      961 cgcggggtct gccggaccgc gccgtacatc tcgtcgtacg ccgtggcggt cagcgtgcgg
     1021 gtcgtgccgg cgaagacccg gtccggccgg ccacccggca ccggcgcatc acccggcgcg
     1081 gtccggccgt cggccgccgt ctcgacccac aggccgcgga cccggccgct gcccttcggc
     1141 gccatcacgg ccaggccgtt cggtaccggt cggaccgatc cgtcgcccgg cacgttgtcg
     1201 acctgcacct tggtcccgcc cggccggcgg ctgaccagcg tggtcgaacc gccgccgtcc
     1261 agctccaccc cgacgtacgc gccgcgggcg gccaggatcc ggcccatctc ggccagcgtc
     1321 gcgccccggc tgtgggtcag ccggttgctg tcgatgctga cgatcaccat cttcttgccg
     1381 tcggcggaga agcccagccc ggtccgcccg gcgtacgccg tgtcgtcggc cggctgcggc
     1441 ttgccctcct tgaccagcag cgcgtgggcg ccgacggcgg tccgcaccac actgccgtcc
     1501 gacgcgcgcg gcgcgaacgc gaccgggacg cggtcgccga ccttcaagcg gccgagctcg
     1561 tccgcgccgg cctcgcggcc gaccaggatc gtcgtcccgg cgggaatgtc gcccgcaccg
     1621 gccgcggctg ccacggcggt caccgtgtcc cccgcgacga cgacctcggt caccttggcc
     1681 gcgccggcca ccgcgtgggc gcgggagtag ctgccccaca gcgtcgtgaa ggcgccgatc
     1741 tcgtccttgc ggatcaccgg gctgttcagc cggttcaacc ggtacggacc ggccgtgccg
     1801 tcgaacagca cctcgaggat gcgaccgacg ccctgggggt cgaaagccac cgcccggtag
     1861 ggatcctcgg actgcgactt gaccagttgg ccgtcggcca cagccgggcc gagcggcgcg
     1921 ccggagttgt tgatgtcgaa gaagtcggcg ttgaccgcgg ccaccgcgcc ggcctcgttc
     1981 gcctgctggt cgagcggctt ggtcgcggtg acctggcccg gcgacaggta gtcgatccgc
     2041 gcacccttgg tgaggtcgac ggacagggtg ttgccctgct gccagccgcg ctcgtcgaac
     2101 gtctcgagcg atccggcggt caccccgggc gccaccgggc gggtgcgttc gtacgtctgc
     2161 agctgagccg gcgaggcgac ggttccggcc gctggggtgg ccgaggccgg gagcagcgcc
     2221 ggagtggcca gcgcgaacgc gagcggcacg gccaccaggc gggtgaggga cggggcaggc
     2281 acagggacct ccggtcgtga acgattgacc agaacagtca acgtgcacgt aacccattta
     2341 caccagggct caccggtgaa tggaccccga aaacttggtg gccccgggcc ggtcgggctg
     2401 gaccggtccc cagtcagcac cggtgcagcg agagcacggc ccggggaaag gaaaacgccg
     2461 accgtgccgg gcgtcggtcg ccacctcact ggcgaccggc tgccctgtgc ggcacggccg
     2521 gcgtctaacg ctgccccgag agggcggtcg gcccgaagga aggtggagcc tcgacctggt
     2581 tccgcaaccg gcaggggagg tacagtccgg tcacggacgg aagatcgcgg tgccaccaag
     2641 agcctgtgcc ggcgacccgt ccgtcgccga caacgcaacg ttgtcacggg gccccggagc
     2701 ggggccatgc tcacgatcaa acatttgcat tggcttttca gaaggcgaca ctacgtgcac
     2761 aagtcgtcac tttccgtact gacgttgcct gccgcaacaa cggaaaagct tgcacgcttg
     2821 accatccggc ccaccgggcg tcgaagcgcc catcctggtt ccggacgtgg tcagtacggg
     2881 taggtgtcgt cccgcctggt cgggtccatg tcccagagcg agaactcgac caccttgtgc
     2941 gactcctcgc cgccggccgg gctgaggccg accgtgtcgt agtccttgga gccgagcccg
     3001 tcgaggtagc cgagcagctc gaacgccgag cgggcatcat cgatatcgtc gatctcgtcg
     3061 tcgtttccct ggatcacagc ctcgtcggcg cggctgcgca cgtaggcgat gaacgcctcc
     3121 ggatcggtca ccacgaagtc gtagcgggcc tggtagctga gccgcatccc gttctccggg
     3181 accagcggct cgtccaggtc ggccaccccc tcgaccagct cccggtagtc ggccgggtcg
     3241 tcgaagtcgt ccggcccgag cggcacgtcg tccagctcgt cggggtcgta ggagtcgatg
     3301 ccgagaaaga tgtctcccca gccccgctcg tgcaccgcgt cggccagcac ccgggactgg
     3361 acccggacgt tctcgatcgc cgtggtggcc cgcaggtcgt gcaggtccaa ggcgtcggcc
     3421 tgctccagca gcaccttggc aagttcgcgg gcggcctcgg cggccgaggc gggctcaagc
     3481 ggctcactca tgcagcgacc gtacaaccat cggtacgtcg accgccgcgc ccggtacgcc
     3541 gaacgcgtcg accaggctgc tcgcgtgcgg ccggacccgc ccgcacaggt cgttcaccag
     3601 cgccgtgatc gccttggacc gcgggccgga cagccggccg tgctccatga accaggcccg
     3661 gtcgttctcg atcgtggtca gcgcgtgcag gtcgtacagc tccttcagcc ggtcccgcgt
     3721 ctccccctcc ggtgcggcgt gcacggcgcg ctggaacgcc tccagcacga cccgctcgac
     3781 gtgcgcccgg ccggccgcga tgacgtggtc ctggcaccgg ttgaacacct cgaacgcctc
     3841 gtcgccggcg tcgatcccgg cccgcagccg gcgggccacg ccggccagca tgtgctgctc
     3901 gcggaaccgc agcagcccgg agtggtagtc gtcgtcacgg agcccggcgt ccgggtcacc
     3961 cgcgtccgac cggttcggca cggcgtcgcg cagccgctcg atcagcccgc gcagcgcggt
     4021 cttctccacc gcgatctcga ccgcctgccc ggccacgaac cgcgcggtgc cgagcgggtc
     4081 gagcttgccg aacgactccc ggtagtcggt cagcaggccc ttcgcgacca gctgcagcag
     4141 gacggtgttg tcgccctcga aggtggtgaa cacgtcggtg tccgccttca gcgtcgagag
     4201 ccggttctcg gccaggtagc cggccccgcc gcaggcctcc cggcacagct ggatcgtctc
     4261 ggtcgcgtgc caggtgccga cggccttggt gcccgcggcc tgggcctcca gcgcccggcg
     4321 gtcgtgctcg tcgctccggc ttccgccgtc cggcgcgctg ccgccgtcct gcccggtggc
     4381 ggtgtcggcg ccgaagatcc gggcgaactc gtcgaccagc tcggcctggg cgaagtgcag
     4441 ggcgtaggtc cgggcgagca gcggaagcag ccggcgctga tgcatccggt agtccagcag
     4501 cagcgcctcc tccgggctgc cgggcgcgcc gaactgccgt cgctgctcgg cgtaccggac
     4561 ggcgatcgtc agcgccacct tgctcgcgtt gatcgcggcg ccgccgaccg agacccggcc
     4621 ctggaccagc gtgccgagca tcgtgaagaa ccggcggtcc gggttctcga tctcgctgcg
     4681 gtaggtgccg tcggcatcca cctgggcgta ccggtcgagc agcgcctcgc gcggcacccg
     4741 gacctggtcg aagacgatcc ggccgttgtc gacgccgttc agcccgagct tggggccgca
     4801 gtcgctgatc gtcacgccgg tcaccggctg cccgtcgtcg gtccggatcg gcaccagcag
     4861 gcagtgcacg ccgagggtct ggccgccgac caccagctgc gcgaacaccg cggccagccg
     4921 gccgtgccgg gccgcgttgc cgatgtagtc cttgcgcgcg gacgcggtcg gcgtgtgcac
     4981 gacgaactcc ccggtcgccg ggtcgtacgt cgcggtggtc tcgagcgcct gcacgttcga
     5041 cccgtggccg gtctcggtca tcgcgaagca gccgagcagg tcaccggtga gcgcgtcggc
     5101 caggtaccgc tcgtggtgcc gctcggtccc caggtgcagg atcgcgccgg cgaacagccc
     5161 gaactggacg cccgccttga ccatcagcga caggtccccg aaggcgagcg tctcgaagcc
     5221 ggcgatgaaa ccgcccaggt cgccctggcc gccgtactcc ttgggaaagc cgcggaccgg
     5281 gtgaccctgc gcggccacct cccgcagggt ggccagcacc tggtcgcggt actcgtcccg
     5341 cgacagccgc agccccgcgt ccagcaggcc ggcgtgcgtc gccagcccgt cccgtacgac
     5401 gtcgcgcgcg gccttgtgcg gcccgtccaa gtactcccgc agcccggtca tggccccaac
     5461 ctatgccgga ggtctcgaaa aactaaggac aatcgggggt tacctgccgc atctgcggcc
     5521 ctaagatggc cagcatgccg attttgcgga tcagtgaggc ggccgctctg ctcggggtca
     5581 gcgacgacac cgtgcggcgc tggatcgacc agaagcgcct gcccgccacc gagcagggcg
     5641 gccggatggc cgtcgacggc cgggagctgg cggcgttcgc gcagcggctg gccgagtcgc
     5701 cggagccggg caccaccacc gccgcctcgg cccggaaccg gatgcgcggc atcgtcaccc
     5761 gggtggtcaa ggacggcgtg atggctcagg tcgagctgca gaccgggccg ttccgggtcg
     5821 tctcgctgat gagccgcgag gcggccgacg agctcggcct cgagccgggc gtcgtcgcgg
     5881 tggcctcgat caagtccacc cacgtcgtcg tcgagatccc ggaggcctag atgccgcgtc
     5941 gaaccagttc cccggcgaaa ccgacgccag gagtcgtgaa ggcagggcgg cgagtcctgg
     6001 ccggtgtggt ggccgttgcc ggcctgctcg cgtcggccgc gtgcgggtcg ggtgactccc
     6061 cggccgcgtc ggcgaacggt tccggcgtcg acggcacggt caccgtgttc gcggcggcct
     6121 cgctcaccgg cagcttcacc cggctcggca aggacttcga ggcagcgcac ccgggcgtcg
     6181 aggtggtctt caacttcgcc ggcagctcgg cgctggccca gcagatcaac cagggcgcgc
     6241 cggccgacgt cttcgcctcg gccgcgccga agaacctgga ccaggtcacc ggcaagggca
     6301 ccccgaccac tttcgtccgg aaccggctgg agatcgccgt gccgaagggc aacccgggca
     6361 aggtcaccgg gctgcgcgac ttcgccgatc ccggccgcaa gatcgcgctc tgcgccgagc
     6421 aggtgccgtg cggcgcggcc gcgcggaagg tgttcgccgc ggcccggatc accccggagc
     6481 cggacagcct ggagcaggac gtcaaagcag cactgaccaa ggtcgggctg ggcgaggtgg
     6541 acgccgcgct ggtctaccgg accgacgtac tcgcggcgaa ggacaaggtc gagggcatcg
     6601 agttccccga ggcggcgcag gcggtcaacg actacccgat cgcgacgctg accacggccc
     6661 cgaacgccga gggcgcccag gcgttcgtcg acttcgtcct gtcgccggcg ggcaagaagg
     6721 tcctggccga ggctggtttc gacgttccgt gagcacccgc ggccggagga gacggacggg
     6781 tggccgactg ccggtcgtcc tgctgctgcc cgcgctgctc gggctcgcct tcctgctcgt
     6841 tccgttgatc ggcctgctgc tcgaagcccc ctggtcgacg ttgccgtccc ggttgttcag
     6901 cgccgaggtc ggccaggccc tgcggctgtc gctgatctgt gcgagtgccg cgaccgtgct
     6961 ctgcctgctg ttcggcattc cgctcgcctg gctgctcgcc cgggcggaca tccccggccg
     7021 cggcgtgctc cgggcgctgg tgaccgttcc cctggttctg cccccggtcg tcggcggggt
     7081 ggcgctgctg ctcgtcctgg gacgccgcgg gctgatcggc gagcggctcg atctgtggtt
     7141 cggcctgacc ctgccgttca ccaccgccgg cgtgatcgtc gcggaggcgt tcgtggcgat
     7201 gccgttcctg gtgatctcgg tcgagggcgc actgcgggcg gccgacccgc ggtacgagga
     7261 agcggcggcc accctcggcg cgggacgctg gctgaccttt cgccgggtca cgctcccgtc
     7321 gatcgcgccg ggcgtcgtcg ccggcgcggt gctgtgctgg gcccgcgcgc tcggtgagtt
     7381 cggcgccacg atcaccttcg ccggcaacct gccgggccgg accaccacca tgccgctggc
     7441 ggtctacctg gcgctggaga cggaccccga cgtggcggtg gtcctcagcc tggtcctcct
     7501 gctcgtctcc gtggcggtcc tggcctgtct gcgcgagcgc tggatcggcg gcctgcgatg
     7561 accttgcacg ccgacctgca cgtacgccgt accggcttcg aactggcgat ggagttgtcg
     7621 gtcgccccgg gcgaggtggt cgccctgctc ggcccgaacg gcgccgggaa gaccaccgcc
     7681 ctgcgtgcac tcgccggcct gctgccgctc gacgacggcc ggatcaccct cgacgacgac
     7741 ctgtgggacg agccgcccgg cgtcttccgc ccggccgacc gacgcccgat cggggtcgtc
     7801 ttccaggact acctgctgtt cgaccacatg agcgcgctgg agaacgttgc cttcggcctg
     7861 cgcgctcggg gtgtcggcaa gcacaccgcc cgggccgagg ctctccgctg gctgtccacg
     7921 gtcggtcttg ccgagcacgc cgcgtcccgt ccccgttccc tctccggtgg ccaagcccag
     7981 cgcgtcgcgc tggtcagggc tctagcgact gagcccgaac tgttgctgct ggacgagcca
     8041 ctcgctgccc tcgacgccgg gaccaccctg cacgtccgcg ccgagctcgg ccagcacctg
     8101 tcccgctacg agggccgcac gctactggtc acgcatgacc ccctcgacgc catggtcctc
     8161 gccgaccgcc tggtcatcgt cgagaacggc cgggtcgtcc aggaaggcgc tcccaccgaa
     8221 atcgcccgcc gcccccggac ggactacgtc gctcacctgg tcggcctcaa cctgtaccga
     8281 ggtaccgccg aaggcaccac cgttcacctg gccgccggcg gcaccgtcac caccgccacc
     8341 ccggccaccg gtcctgtgca cgtgtcgttc cccccgtcgg ccgtcagcct ctaccccgac
     8401 cgccccagcg gcagcccccg caacacctgg ccggtcgtcg tcaccgggat cgagcagcac
     8461 gcccacacgg tccgagtccg cctctcgccc gctccggact cgtcggcccc caccgatctg
     8521 ctcaccgacg tcaccaccgc cgcagtcgcc gagctccacc tcacccccgg ccgccacctc
     8581 tgggccaccc tcaaagccac cgagacccag acctacccca gctgacccag ctccgtactc
     8641 cgactttgag cacgcgccag ccaccacatc ggcgtacgag tggctggcac gtgctcagag
     8701 tcgcgtcggg cgccggccgg gcgcgcttgt tgcctggcgc aacgaggggg acggcggata
     8761 ctggggggtg gaccagaccg cgcgagggat ggggagcacc gtgatcgagc cgagtgtcga
     8821 gtggcgggaa gtggtgcacg acgacgaggc cgagcggcac cggcggcagg cggagcggtt
     8881 cgtggagctg caggcacgca ggtcggggga gttcggcgcc gggcgcgcgt cgcaccgcca
     8941 gcaggtggcc gcgttacggg ccgtgctgac ggtgccgagc gacctcccgg agtacgcgca
     9001 gcaaggactg ttccgcgtcc ccgacacgta cgacgcctgg gtgcggctct cgaacggcgg
     9061 cttcaaccgg gcgccggacg cggtccccga cgtgcacggc ttcgcggtga aggtgttcgg
     9121 caccagcggg ccggccgcgc tcggcggcga ggcggtctgc caggacctcg tcctgatcaa
     9181 ccacgagcgg ctcagctctc cgaccagcga ggagttcacc acgctggtca ccaccgccgc
     9241 cggcacgtcc ggccaggtcc tgcgcgcggt cgcccggcag cccagcctct tccctcgcct
     9301 ccgagcggcc tccgccgcgc tgaagacgcc gttctccggg ttcgcgaccc aggacttctt
     9361 cagcgccgcc ccgatcgcct tcggcccgta cgccgtccgc gtgaagctcg ccgcccgcgc
     9421 ggaccaggtc gatccgcgcg cgtccggcga ctgggcggcc gacgtgcacg cccggctcgc
     9481 cgacggcccg ctgcactacg acctccaggt ccagttcttc gtcgacgagc agcgcacgcc
     9541 gatcgaggac gcctcggtgg tctgggacac gccctgcctg accgtcgccc ggttgaccgt
     9601 cccacggcag cggccggacc cggccctggc cgacgagatc gagcgcgcga gcttcgaccc
     9661 gtggaccgcg aaggccgagc accggccgct gggtgaggtg atgcgggccc gccggatcgc
     9721 ctacgcggcc agccggcaga accgggacgc gcagtgagaa atcctcagca cgacgttccc
     9781 acgtcgaagt tacggcctgt gacagcactg ccacgaatcg acatgatgtc acagcgcttt
     9841 ccccgctcaa agtgagcgga atgtgacaaa gagtgtttag ttactcactc gtagtgcgtg
     9901 agttcttcac ggtctagtcg tgacgcgatg cactacgccg acccccctcg cgctgcccaa
     9961 gatgtgccgg ggcaccgacg agagaggggg acgaaccgcc gtggaatcct acgagctgta
    10021 ctgcctggcc gaccggctgt tctacgacac cccggccaat cgcggtgccg agcaccccga
    10081 cttcgcccag gcttcgcgac ccgtcccggc cggctggcag cacgtcgccg gcgagatgtg
    10141 gatgcactac gccccggacg ggctgcgact gcccgcccag ggctggaagg tccacgtctc
    10201 cgctggactg gccgacgccg agcgcgtgct cgacgcggtc tgggactact gcgtcccccg
    10261 tggcatcgcg ttcaagttcc tgcgcaacga gccggtcctg gtgatggtca actcgaagtc
    10321 ggccccgcgc ggctccagcg gcaagctggt caccatctac ccgaccgacg aggcccagct
    10381 ggagctggtc ctcaaggagc tcgacgacct tctccacggc gtccgcggcc cgtacatcct
    10441 gagcgacctc cggtacgccg aaggcccgtt gttcgtccgg tacggcgcgt tcgtcagccg
    10501 ctacaccctg gacgccgccg gcgaccgggt gctcgcgctc gaggacgacc acggccggct
    10561 ggttcccgac caccgcagcc cgaccttcag cgtgccgccg tgggtgcggc tgccgtcgtt
    10621 cctcgcgtcg cacctggagg cccgcaacgc ggtcaccacc aacgacctcg cgtacacgat
    10681 cgacggcgtc atccagttct ccaacggtgg cggcgtctac ctcggccacc acaacgagac
    10741 ccaggaccgg gtggtgctca aggagggccg tccgctggcc ggcctggaca tgtccggccg
    10801 ggacgcggtc gcccggatcg ggcacgagcg cgacatcctg cagcgcctcg acgggctcgg
    10861 cgtcgtaccg aaggtgcacg actacttcac gctcggcgat caccacttcc tggtccagga
    10921 gttcgtcgac gcgaacccgt tgcagcgcga gctcgtccgc cgctacccgc tgacccggcc
    10981 ggacgcgtcc gccgccgacc tcgcggagta cgccgagtgg gcgacccgga tggtcacggc
    11041 ggtccagcag gcggtcggcc agctgcacgg ccggggtgtc gtgttctgcg accttcaccc
    11101 cgacaacgtg ctgctgagca ccggcgaccg gctggtcctg atcgacttcg aggtggccac
    11161 gctggccgcc gagcaggccc ggtccgcgct ggctcatccc ggctacgcgg cgcccggcga
    11221 ccgccaaggc acggacgtcg acctgtacgc gctggcctgc atcaccctcg gcctgttcgc
    11281 gccgcaggca accatgctgc tgaacctgca tccgggcaag gctttccagc tcgccggcat
    11341 gatcgccgag accttcccgg tgccgagggc aacgctcgac gccgcagtcc ggacgatcgt
    11401 cggcccggag ctcaccgagg acccggagat ggcggcgctg ccgctgcccg gccgcgccgg
    11461 ctggaccgac gtacgggcgg cgctgacgac ggcgatcgtg gcgagcgcga ctccggagcg
    11521 ggacgaccgg ctgttccccg gcgacatcgc gcagttccgc ccgggtggtg gcatcaacct
    11581 cgccaccggt gccgcgggtg tcctgtacgc actggcgaag accggggccg gccgcttccc
    11641 ggagtacgag gactggctgc gcgagcacgc cctgaccacc gagaccggcc caggcctgta
    11701 cgacggactg cacggagtcg cccacgtcct cggcgagctc ggccaccggc aggacgctct
    11761 cgacgccatc gaccgcacgc tcgccgacga cctgggcagc cgcgagctcg gactgcactc
    11821 aggtctcgca ggcatcggcc tcaacctgct gcacttcgcc gcgaccgagc cgggtctgca
    11881 gggcaaggcg gtccgcatcc tcgacctggt cgcggaccgg ctcggcgacg tcaccgacgt
    11941 tccggaactg agcggcgagg gcaaaccacg ggccgggctg atgtacggct cctccggtcc
    12001 cgcactgctc tttctcacgg cgtacgagcg caccggcgac accggcctgc tcgacctcgc
    12061 ggagaccgcg ctgcggcagg acctgcgccg ctgcatcccg acgccggacg gcacgctcca
    12121 ggtcaaccag ggctggcgga cgctgcccta cctggaggaa ggctcggccg gcatcgcgct
    12181 ggtgctcagc cgctacctgc agcaccggcc cgacgagaag ctggccaccc agctggctgc
    12241 gctgcggctc gtcacccact gcgcgtacta cgtgcagccc ggcctgctga tgggtcgcgc
    12301 cgggctgctg ctgaccgcgg ccgagctcgg cgacagcacc gatgacctgg tccgcggact
    12361 cggctggcac gcgctgccgt acgagggcgg actgatcttc ccgggcaacc agctgctccg
    12421 tctctcgacg gacctggcca ccggatccgc cggcgttctg ctggccctgg gaaccgcgct
    12481 gcacgagcgg ccggtgtccc tcccgttcct cggacctccc cagtggtccg agtccccatc
    12541 ccgacgactt cctccgaagg aggtgtaaac acatggcact tctcgacctt cagggtctgg
    12601 agaccccggg ctacggccac ggcggccacc accacggcgg ctccacgctg accgtgctcg
    12661 gctgcggttc gcagcgtccg agcaacctga gccttctgct ctgccactga tccggacctg
    12721 ctgcacgagg tttccgaagg ccctgggcgg gcggcaactc ccgcccaggg cctgcctggc
    12781 agttgccggc gtagcgctgc cgggcccgtg ctgacgcctt ggggaggaag cgaccatgga
    12841 ctacccaccg gccgagcggc ttccgctcgt cgagcaggtg cacggacagg ccgtcgccga
    12901 tccctaccgc tggctcgagg acgccaccag tccggagacc ctgcgctggc aggccgccca
    12961 ggacgagctc tggctcaacc acgccgccac cctgcccagc cgctaccact tccgcaaccg
    13021 cgtgcgggcg ttgtccgcgg tcggttccgt ctccacgcct gtctggcgcg gtgaccgctg
    13081 cttcgtgctc cgccgcgagc cgcggcagga ccaccccgta ctcatggtcg acgacaccgt
    13141 tctgctcgat cccgtgcagc tcgaccccag cggcctgacc acgctcgaca gctggcagcc
    13201 gtcgccggac ggatcacggc tggcgttcca ggtctcccgc ggcggtgacg agcggtccgt
    13261 cctgcacgtg ctcgacgtcg ccaccggtga ggtcgtcgac ggaccgatcg acggctgccg
    13321 ctactccccg atcgcctggc tgccggacgg aaaatccttc tactacgtgc gactccgccg
    13381 ggtcctgctg caccacatcg gctcggccga cgaccagcag gtgttcaccg acgaagcgtc
    13441 gtacgggctg gatctcagtg cggacgggcg ctggctggcc gtctccgcgg cccgcggcag
    13501 ggggaacgac ctctggctgg cggacctcgg caacgacgcg ccgccgcagg tgctgcaggc
    13561 aggtgccgac gcggtcacgg tggtctcggt cggcggcgac ggccggctgt acgtcgtgac
    13621 gacaaaggac gccccgaccg gccggatctg catcggcgac ccggagaatc cactgatctg
    13681 gcacgactac gttgcggccg atcccgatgc tccactgagc agcctggccg tgctggacaa
    13741 ggtggtgctg gtcggccgtt cgcgagcggg aatcggtgag atcatcgtcc acgacctggt
    13801 caccgggcga cgtctcggcg agattcccct tccgggcaag ggttctgtgg gctcgctgac
    13861 gacacggccg gagggtgggc accaggcctg gttctcctac accgacagcg tgacgccggc
    13921 tgcggtctac tgctacgacg cgaccaccgg cgagaccagt ctgtggtccg agccgccggg
    13981 cgccgctccg gtcgccgccg cgacggcgac gccggtgagt ttccggtccg gcgacggcac
    14041 cgagctggac atgctggtca tcgccggtcc gggcgacggt atgccgcgac ccacgatcct
    14101 ctacgggtac ggcggattcg gccagtcgct gaccccggcg tactcggcct tcacgctggc
    14161 gtgggtcgag gcaggcggcg tgttcgtcac cgcgacgctg cgcggcggcg gcgagcgcgg
    14221 tgacgcgtgg caccgcgccg gcatgctcga ccagaagcag aacgtgatcg acgacttcct
    14281 cgccgcggcc gagcagctga tcgctgacgg ctggacgacg tccgaccagc tcgggctctg
    14341 cggtgagtcc aacggcgggc tgctcgtcgg tgccgcgatc acccagcgcc cggagctctt
    14401 cgccgccgcg gtctgctcgg cgccgctgct cgacatggtc cgctacgaac ggtccggcct
    14461 gggcccgcag tgggtcccgg agttcggctc cgcctcggat cctcagcagc tgaagacgct
    14521 gctgagctac tcgccgtacc accacgtcac gcccgggatc cgctatcccg cggtcctgtt
    14581 caccgccttc ggcaacgaca cgcgggtcga tcccctgcac gcccgcaaga cctgcgccgc
    14641 cctccagcac gcgacctccg gcccgcctga ttcccgtccg gtgctgctgc ggctcgatcc
    14701 ggacgccggg cactcggcgg gctcgacgtc ccagggcatc gcgctggctg ccgacatgct
    14761 cgccttcctc gccggccaac tccgcctcac cccgcgcagc gacccatgag cctgaccttc
    14821 gcagcggtgg ctcggcacgg ccgcgggtgg ttgccggtga tcgcggtgac ctccgtggcc
    14881 ggcagttgcg tctcgctcgc gctgccctcg gtgctcgggc gttcggtgga ctcgatcgtg
    14941 gccgggcacg gctaccacca gtggctgacg atcgccgtgg cattggttgc caccggcatc
    15001 atctgtgcgc tggtcgacgt cttcgccggt acggcgtgtg tcgccgggac gacggcctgg
    15061 ctgcggcacg ggctggtccg gagggtcgtc cgcggtggtc ccgaaggcag ccgcggcttc
    15121 gacaccggcg acctggtcag ccgcgtctcc ggcaacgcgg tcgacgccgc ccaggccggg
    15181 cccgcgctga tcagcgcctt cgccgcggtc ctcccgcccg cgggcagcct ggtcctgctg
    15241 gcgctgatcg acccctggct ggcggcggcg ttcttcggcg gcgtcgcgct cgtcatcgcc
    15301 gtgctctgga tcttcgcccg ccggaccgct cggatcagcc tcgcctacca ggagacccag
    15361 ggccggatct ccggcctgct gaccgagtcg ctgaccggca tccgtacgat cctcgccgcc
    15421 ggcaccgtcg gccgcgagga gcggcgcatc ctgagcctgc tgcccgagct gcacaagcac
    15481 ggcctgctga cctggcgcgt gctcgcccgc tccggggccc aggccgcggt ggtcggaccg
    15541 ctggtcctgg tcgcggtcct cgcggtcggc ggcctgcagc tcgtcgaggg caggatcacc
    15601 gccggcgaac tcttcgccgc cggccagtac gccgtactcg gggcgggcct cggcagcctg
    15661 accggcgtca tcggggagat cgcccgggcc cgcgccgggg tgagccgggc ggccgaggtg
    15721 ttcgcgatcg agtcggtgcc gcacggcacg ctgccgctgc ctcccggacc gggccgcctc
    15781 cgcttcgacg gcgtgagcgt ccggtccggc gacaccgtcc tgctcgacga gatccagctg
    15841 gacctgcccg gtggtgcgac ggtcgccgtc atcggtccga gcggcgccgg caagtccgtt
    15901 ctggccgcgc tggccgcccg tctgcgggac ccgtcgacgg gtcaggtcct gctcgacggc
    15961 gtaccgctgc aggccgtcca gcggcacgct ctgcgccgag cggtcggctg cgcgttcgag
    16021 cggccgacgt tggtcgggtc gaccatcggc gacgccatct cgcaccgcgc gaacagcacg
    16081 gtccggaccc tcgccgcggc ccgggccacc cacgcgcacg acttcgtcag ccgcctcccg
    16141 cagggctacc gtactccgtt gcccgaagcc ccgatgtccg gcggagaacg ccagcggctc
    16201 ggcctggccc gcgcctggcc cgcggaccgc ctgctcgtcc tggacgacgc cacctccagc
    16261 ctcgacaccg cgaccgagat gcagatcagt cgcacgctca ccgacgaccg gcaccgtcgt
    16321 acccggctga tcgtcaccca ccgccccgcc accgcagctc gggccgatct ggtggtctgg
    16381 atggagcgag gccgcgtccg tgcggtcggc caccactccg agctctggcg gcaccccgat
    16441 taccgcgagg tcttcggatg aagcgcgaac tgcggtacgg cgtcgcggcg ctgcgcaacc
    16501 ggtcggcact gaagctggcg ctctggtcgg tgcccgagat cctgccgacg gcgctctacg
    16561 gcatcgccgt ggcgcgcgcg acggacagct tcctcgccgg tcacgcctgg cagggcatcg
    16621 cctggctggg cggactggtc gccaccgcct gcatcggcgc ggccggctcg taccaggtct
    16681 acggccgcct cggcgagctg gtcgagccgc tccgcgacga cctggtccgc cgggttgtcg
    16741 gcggcgccct gcggaccggc gacgacgcgg cggtggcccg gttgaaccgc caggtggaga
    16801 tcgtccggga caccttcgcc ggtctggtgc tggtggtccg cagcttcgcg gtcacactgt
    16861 tcggcgttct ggccgggttg ttgtcgctgg caccggcgat cgcggtgctc gtcgtaccgc
    16921 cgttcctgct cgggttcgcg gcgtcgctgg cggtgctcgg gctggcggcg gaccgggtgc
    16981 gcgcgtcgct gcaggccgac gaggacctgg cggcggccgc gggcatgacc ttcagcgggg
    17041 tgcgggacat caccgcgacc gggtccgagg agttcgtcga gcacttcgcc gggcggccga
    17101 tcgaggcgca ggccgcagcc gagcggtcgc tggcgaaggt ggccgcgctg cgcacgctct
    17161 gcttcgccgt cggcggctgg gcgccgctgc tgatcctgct ggcggccggt ccctggctgg
    17221 tgggccgcgg cgtcagcacc gggacactgc tcggcggcct cacgtacgtc ctgatcggcc
    17281 tgcagccggc gctcagcacg gtgatgggcg ccctgggcga cagcggcctg cggtacgtcg
    17341 tgacgctcgg ccggatcctg tccctgcagc cgcctcccga gcggcctttg cgcggctccc
    17401 agcagtccgg cgcagcgatc gagccggccg gccaccaggt ccgggcgcgc ggtctcacct
    17461 tcgcctacgg gccggccgct gagccggtgc tcgagcggct cgacctggtc gttgccgagg
    17521 gcgagcacct cgcggtggtc gggccgagcg ggatcgggaa gtcgacgctg gccgggctga
    17581 tctgcggtct gctcacgccg accgaggggc ggctgctgct cggcggcgta ccaccgagcg
    17641 aggtgacggc ggagcggctg gcggggacgc gggttctcat tccgcaggag gcctacgtct
    17701 tcagcgggac cgtccgggag aacctggact acttgttgcc cgacgcctcg acgtcggagg
    17761 tcgagcaggc tgtcgacgcg gtcggttccg cggccctggt gcgacggctc ggcggactgg
    17821 atgcgacgct ccggccggga gacctctccg cgggcgagcg tcaactgatc gccttgaccc
    17881 gcgcctacct gtcgcccgcg ccgctggtgg tgctcgacga ggcgacctgc ttcctcgacc
    17941 cggaggccga acgccgcgct gagcaggcgt tcgcccagcg cggcggcacc ctgatcgtca
    18001 ttgcccaccg catcagttcg gcgttgcgag cccagcagat tctcgtgctg gacggcaacc
    18061 gagccaccct gggcacccac cagacgctgc tccgcgcctc gccgctctac cgggaacttc
    18121 tgggccactg gcaacccgag gaccggatcc agcccgcctc ctgagactgg cttgcgggac
    18181 aggcaagccg gacgcggcaa ccattcgtcg cggcggcggt ccgcggtcag atccagccgg
    18241 cgtcctgggc cttgcggatc gcctcgatcc ggctgcgggc accggtcttg gtcaggatgc
    18301 gggacaggta gttgcgcacc gtaccggcgc tcagactcag tgtgcgggcg atctcctggg
    18361 cggtggcgcc ggtggtgacc tggcgcagca cctcgcactc gcggtcggtg agcgggttgt
    18421 caccggcccg cagcgcggcg accgcgaggc ggacgtcgac gaccggcagg cccttggcca
    18481 cgtcccggac cgcctcgacc agttggtccg tggtcgcgtc ggtcgcgatc aggccgaccc
    18541 gcggcgcctg cttgaccagc gccatgctgg tcgcggcgat cgcctcgtgg tcgaccagca
    18601 ccagcacgcc ccggccggtc aaccgccggc acagctcctc gatcccgacc ttgccgggca
    18661 gctgcgggtc gagcacgacc acctgcggac gcagccggac ggcggcgagc acgtcgtccg
    18721 accggtccag cgcggccagc acgtcgagat cggactccct ggacagcacc gcggccagtg
    18781 ctccacgcac caacgtgccg cggtgcccga ggaccactcg gatcaccgca cgcccccatc
    18841 aatcgtttgc ctcaaccacg ggccctcccg gcccgtgact cgatcaacga gcgaacgtga
    18901 gttacgacac gcacgattcc tcgccggtcc gcccggacaa ccccgtcgcc cacgccgtca
    18961 tcagcgctcg tcgcgagcgt ggaaaccgtt ctgttgttgg gttttcgatg gccggaggca
    19021 agaaaaattt cagccgaagt tgggcatacc ccttgcgttc gcggcgcggg tcacgcacga
    19081 tggctcggtc aacgccgtta ccggcgcgtg accattcgga cgctgtctcg tgacatcgcc
    19141 cgagtgcttg tcccctgcac ccctggaggg agtggtacct cacccagact gtggagcccg
    19201 gtacggccgc cgacagcggc cacgatccga gcctcacgca cacaggtgac gaccaccatc
    19261 atcccgccgg ccggcccgca cttccggcgc gccgcgggat tctcggggaa agtgcgcacg
    19321 cggctgaatc ggccgggctg gagaagttca ccatgcccag ctcatgagga gcagattctg
    19381 atgtccaaag ctcgacatgc ccgaccccgg cgaagtaccc gccggatcgt ccggaccctc
    19441 tccatcgccg gcctcggcgc cgggatcacc gccgtcggcg cgggcgctgc tttcgcgacc
    19501 gactacacgg tgaagtccgg cgacaccctc tccgagatcg cccaggccaa cggcaccgac
    19561 tggcaccagc tggccgagct gaacggtctg gacaacccgg acctgatcct gatcggccag
    19621 acgctcaagc tcgacggcgt gaacaaggcc gccgtcaccg agcgccggtc cacggccaag
    19681 acggagcgca agaccgagcg ccgcagtgag cgcaaggtcg aggccaggag cgagcgcaag
    19741 accgagcgca agtccgagcg caagtccgag cgcaagtccg agcgcaaggc tcgtaccagc
    19801 cggtcggagt cgacccgcgg cggaaacggc ggcagcgtct cgatgagcgc ggcctggcgc
    19861 aaggtcgccc agtgcgagtc cggcggcaac ccgcgggcgg tgaacccgac gggcaagtac
    19921 cacggtcttt tccagttcga ccggcagacc tggcgcagcg tcggtggatc cggcctcccc
    19981 tcgaacgcct cggccgccga gcagctgatg cgcgcgaaga agctgtactc gcagcgcggc
    20041 gcgtccccgt ggccgtcctg cggccgcttc ctgcgctgac ccgcagtctg gtgaacggtg
    20101 gtgccggtcg cagccggcac caccttcacg tgcaggcctc ccgtcgcacg ctcagtgcgt
    20161 gagcaccagc atccggttgg ccccggcctg gaactcgtac ggcacccgac gaatctccgc
    20221 ctgaacaccg tcgagctgct cgagcagctc cggcaggtac tccaccggct cccccgcacc
    20281 ctgcttgacc agcgggaaga cccgcacctc ggaccgcgcc acccggacca gctcgcgcaa
    20341 cgccgccaga tgccagtcct ggtcgtactt gtcggcccag gtgaacagca ggtgcgagct
    20401 gagcaccagc tcgaaccgcc ggtccgggaa cggcagctcc ggcaggctgc ccggcacgta
    20461 ccgctcgggc gcgaccgcga cgtcggtcag gaaccggtcc gccgcgtcga gccgcagctc
    20521 gtctttgcgc tccggcgatc cgtaccagtg ccagacgaag ttgcccgcgt gctcgtccac
    20581 gatgcccgag gtggccggca ggctgcgccg caccgtgtcg accagctccg ccgccggcag
    20641 ctcgtacgcc gggtcgaccg cgaccgcgtc gacgccccgg gccgccgcct cggccgtgaa
    20701 cccggcgccg ccggcgcagc agtccagcac ggactcggga aggtcggaca gatcgaacat
    20761 cgcctcgtac tcggcgtacg agcgggatgt caccagcacg gatctacctc tcgacggtgg
    20821 tcctggtcag ccggcggtcg agaagggtgg ccccgaacgc cagagcgagg aacagtagcg
    20881 cgacgagcag acagttcagc aggacctggg cgtagccgag ctcgccgacg tcgacgaacg
    20941 ggtacgggta gaagccgacc agctcgccgc ggaccagcgt gaaggcgagc cacagcaggg
    21001 ggaacgcgag cgaccagccg acgatctcgc ggtcggtgcg gtcgcgcggg ccgaacagca
    21061 gccagcccac gacgccgagc accggagtgg ccgtgtgcag caggaagttg gtgagcgcgg
    21121 ccgcaccgga caactcgtcc agcccggcca gcgccacgtg gtagacgatc ccggtcaccg
    21181 cgatgcagag cacaccgttc agccggagcg tccggaacac cgtggagtcg gaggcggcgc
    21241 cgagcgcgag cagcagcgtg gtgccaccga gcagcaggtt cgactggatc gtgaagaagg
    21301 cgaagacgtt gagcacccgg tcgggattgt ccgggaagaa gccttcggtc gtggtcgccg
    21361 tgacgaccag ttgcacgatg atgccgatcg ccacgaccgc agccgtcacc gcgaaccaga
    21421 gccgccccgc accgaacttg gtcatgaccg caatctacgg tgcgggagcg gagccggccg
    21481 ggagcggcga ggcggaacac tcaggcctcg acccggtcct gcttgctgtc ggcgtcctcg
    21541 tccacgtcgt cgccgtagct gaacgagatg aaaccgtcga tcaccagcac gatcgtccag
    21601 gtccaggccg gaccgagcag cgcgtcgtac ccttcgccgg acagcaggcc gaggccgatc
    21661 atgatcgcgc aggccacggc gtacgaggtg aggtggcggt accagccctg ccgctcccag
    21721 cgggccttct cccgggtccc cttgcgtggc ttgtacggcc gcggcccgcc ggcgaacttg
    21781 tgcgccgccc agccgtccgc ccactgcagc gtgcggtggc cgaagccgac actgacgccg
    21841 atgaagatcg cggccagcga gtgcttgaac gacggctcac caccggtgcg gatgtcgatc
    21901 acgctggcga ccagcatcac gacgtccacc agcggcacca tcacgagcag cgccatgccc
    21961 agcttcggca gccggaacag gtagcgcgtc gtcaggccgg cggcgagcag gacccagaag
    22021 ccgatctcgc acgcggcgat gacagccagc agcacggcgt ccaccctttc ttttttgata
    22081 cgactgtgtt gacaagaacc acggtaacac aggagtgcta aaaagggcgg gtgccgaaaa
    22141 tcgtcgatca cgaagcccgc cgcgaggaga tcgcccaggc gctgtggcgg gtggtccgtc
    22201 gcgacggcat ccgctccgcc tcggtccgca ccgtcgccgc cgaggccggc tggtccgccg
    22261 gcgcggtccg ctactacttc cccgaccagg acggcctgat cagcttcgcg atggacctgg
    22321 tctcccgccg ggtgcacgac cggatcgccg cgctgagggt gaccggcagc gcgaccgaga
    22381 tggctctgcg gtacctggag gaagtgatcc cgctcgaccc cgagcggctg gccgagttcg
    22441 acgtgtggct gtcgttcatc gcccaggccc aggccgagac cggcgccggt gggctgcgtg
    22501 agcatcttgc gccgtccacc gagggcctgc gccggctgtg cctgtcgatg ctcagcgagc
    22561 tggcccgg
//
