LOCUS       NC_013729              22550 bp    DNA     circular CON 20-MAR-2024
DEFINITION  Kribbella flavida DSM 17836, complete sequence.
ACCESSION   NC_013729
VERSION     NC_013729.1
KEYWORDS    RefSeq.
SOURCE      Kribbella flavida DSM 17836
  ORGANISM  Kribbella flavida DSM 17836
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Kribbellaceae; Kribbella.
REFERENCE   1  (bases 1 to 7579488)
  AUTHORS   Pukall,R., Lapidus,A., Glavina Del Rio,T., Copeland,A., Tice,H.,
            Cheng,J.F., Lucas,S., Chen,F., Nolan,M., Labutti,K., Pati,A.,
            Ivanova,N., Mavromatis,K., Mikhailova,N., Pitluck,S., Bruce,D.,
            Goodwin,L., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Chen,A.,
            Palaniappan,K., Chain,P., Rohde,M., Goker,M., Bristow,J.,
            Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., Klenk,H.P.
            and Brettin,T.
  TITLE     Complete genome sequence of Kribbella flavida type strain (IFO
            14399)
  JOURNAL   Stand Genomic Sci 2 (2), 186-193 (2010)
   PUBMED   21304701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7579488)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Saunders,E., Brettin,T., Detter,J.C.,
            Han,C., Larimer,F., Land,M., Hauser,L., Markowitz,V., Cheng,J.-F.,
            Hugenholtz,P., Woyke,T., Wu,D., Pukall,R., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     The complete genome of Kribbella flavida DSM 17836
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7579488)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Saunders,E., Brettin,T., Detter,J.C.,
            Han,C., Larimer,F., Land,M., Hauser,L., Markowitz,V., Cheng,J.-F.,
            Hugenholtz,P., Woyke,T., Wu,D., Pukall,R., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2009) US DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000024345.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 02:06:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,131
            CDSs (total)                      :: 7,069
            Genes (coding)                    :: 7,033
            CDSs (with protein)               :: 7,033
            Genes (RNA)                       :: 62
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 36
            CDSs (without protein)            :: 36
            Pseudo Genes (ambiguous residues) :: 0 of 36
            Pseudo Genes (frameshifted)       :: 8 of 36
            Pseudo Genes (incomplete)         :: 29 of 36
            Pseudo Genes (internal stop)      :: 4 of 36
            Pseudo Genes (multiple problems)  :: 4 of 36
            ##Genome-Annotation-Data-END##
            ##Metadata-START##
            Organism Display Name             :: Kribbella flavida DSM 17836
            Culture Collection ID :: DSM 17836, JCM 10339, KCTC 9580, NBRC 14399
            GOLD Stamp ID                     :: Gi02235
            Funding Program                   :: DOE-GEBA 2007
            Gene Calling Method               :: GeneMark
            Isolation Site                    :: Soil from China
            Isolation Country                 :: China
            Oxygen Requirement                :: Aerobe
            Cell Shape                        :: Rod-shaped
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28C
            Gram Staining                     :: gram+
            Biotic Relationship               :: Free living
            Diseases                          :: None
            Habitat                           :: Soil
            ##Metadata-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:11:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2567866
            Orig. end                         :: 2590416
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP001736.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4082793
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Jonathan A. Eisen (jaeisen@ucdavis.edu)
            David Bruce (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Finishing done by JGI-LANL
            Annotation by JGI-ORNL and JGI-PGF
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22550
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22550
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22550
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12550](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12550
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(129..143)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(256..1053)
                     /locus_tag="KFLA_RS12165"
                     /old_locus_tag="Kfla_2458"
     CDS             complement(256..1053)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020386002.1"
                     /locus_tag="KFLA_RS12165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2458"
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="WP_012920088.1"
                     /transl_table=11
                     /translation="MTSPDPSTVRGPERAAGGAAVPKAVQVADLSVDLGGRLVLRGIDL
                     QIRPGEVVAVLGANGSGKSTLVRTIVGLLPAARGEVRLFGTPVPRFRQWSRIGYVPQRI
                     TAAGGVPATVAEVVTSGLLSKRRWFRPLTAAGRAAVDRSLELVDMADRRKDAVAELSGG
                     QQQRVLIARALVSDPELLVLDEPTAGVDLASQDIFADAIRERVARGTTVIMVSHDLGPM
                     DALIDRSIVLRRGRIVYDGPPHASQTHAHVHPHPVEDEPGWLT"
     gene            complement(1050..2021)
                     /locus_tag="KFLA_RS12170"
                     /old_locus_tag="Kfla_2459"
     CDS             complement(1050..2021)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020386001.1"
                     /locus_tag="KFLA_RS12170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2459"
                     /product="metal ABC transporter substrate-binding protein"
                     /protein_id="WP_041289287.1"
                     /transl_table=11
                     /translation="MRSGFRAVTAGFAALAVLTLAGCGGDATDSSGGSGDKLDVVASFY
                     PLQFIAQQVGGDAVEVTTLTAPGVEPHDLELTPKQVGSITDAKLVLFEKGLQPAVDEAV
                     AQNAEQAGFDVAPAATLEATGAHFEHEEEHAEEAGTDKHEEEGGAEELDPHFWLDPVRY
                     AAVVQAVTDKLAEVDAAHADGYQERGKALVDEVTKLDTEYKTGLQSCKLKTFVTSHEAF
                     AYLAKRYGLQMVGIAGFTPDAEPAPQRIKEVQDIVRKQQITTIFYEELVSPKVAQSIAR
                     DLRVQTAVLSPIEGLSDANSQETYLTLMRENLSELRKANSCA"
     misc_feature    2019..2034
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.66"
                     /tool="antismash"
     misc_feature    complement(2021..2034)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.48"
                     /tool="antismash"
     misc_feature    2021..2035
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 26.44"
                     /tool="antismash"
     misc_feature    2022..2035
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.33"
                     /tool="antismash"
     misc_feature    complement(2022..2037)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.15"
                     /tool="antismash"
     misc_feature    2028..2042
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.72"
                     /tool="antismash"
     misc_feature    complement(2067..2081)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            2075..3424
                     /locus_tag="KFLA_RS12175"
                     /old_locus_tag="Kfla_2460"
     CDS             2075..3424
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020386000.1"
                     /locus_tag="KFLA_RS12175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2460"
                     /product="YibE/F family protein"
                     /protein_id="WP_012920090.1"
                     /transl_table=11
                     /translation="MARRAAGRRRADTKGNRRRRISIPTGHGHGHGHGGWADSGEHVLD
                     TSVVDRDAVVARRVRVVVAALLVPLIAAAVIAMVVMWPGGDLVVQSAHSTGAGGTVQKL
                     EPCPETPADCDQATVRIDSGPEADKGREVPVEVPKGKQAAIPIEVGDKVLLGVQDGAPL
                     TERYQYVDHDRGRPLLLLAGIFAVAVVVLSRWRGFAALIALGVTGVTLTQFIMPAILKG
                     SNPLLVAVVGGAVIMVIALFLTHGVNAQSSVALAGTIAALGLTAFLGWAFVKFSDLSGL
                     GSEGASVVKAYVPDLDLAGLLVAGIVIGALGVLDDVTVTQASAVWELSAANPAASRAAL
                     FGAGLRIGRAHVASVVNTLVLAYAGAALPILMVFAISGTKAGYLISTEMVAIEVVRGLV
                     GSLGLIAAVPLTTALAAMAVADRSRDLVAGPERLASGEENADPVAEPRES"
     gene            3601..4749
                     /gene="eboE"
                     /locus_tag="KFLA_RS12180"
                     /old_locus_tag="Kfla_2461"
     CDS             3601..4749
                     /codon_start=1
                     /gene="eboE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020385995.1"
                     /locus_tag="KFLA_RS12180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2461"
                     /product="metabolite traffic protein EboE"
                     /protein_id="WP_012920091.1"
                     /transl_table=11
                     /translation="MRFRHPDGSTVHLAYSTHVHPAEDLDGVIAQLDGCSSLVRKALDV
                     PVLGIGLWLAHELADQLANSPAALNRLRRALGRNALEVVMLNGLPYADFRAKVVGQQVY
                     LPDWTQPERLRYTLDLIEVLAKLMPTDAAYGSISTPPLAWRFPWSRRRDAVARQAFDRL
                     QVRLAQVGTNAGRRIRIALEPEPGCVLEMVPQATHWLTPYAGSALIGLCLDTCHLAVQF
                     EDPAASFAVAQAAGVEIVRSQLSAALHVPDPRDEDAQRLLNEFAEPKFLHQTREWGGPG
                     VDNLDQADQLSGHAAWRVHFHVPVHAPPRAPLTSTTGVLEDCLNHLVGGPHPLTHHLES
                     ETYAWSILPDGPTNQQELAEGIAAELSWLRQRIVAHGLEELT"
     gene            complement(4771..5766)
                     /locus_tag="KFLA_RS12185"
                     /old_locus_tag="Kfla_2462"
     CDS             complement(4771..5766)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020385993.1"
                     /locus_tag="KFLA_RS12185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2462"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_041289288.1"
                     /transl_table=11
                     /translation="MRRPTLHAVAARAGVSKSSVSRVINGEPTVAPEIRQIVMAAVTEL
                     GYVPNGAARNLVTQKTNTIAIIVSDPPAGLASDDPMFAMVVRAASRQLEAAGKQVSLVL
                     AGSDESRKRVEQYLAAGHVDGAMLVSMDGADPLPAVLARTGLPIVSHGRLSTPGLMPWV
                     DNDNLGGARLAVRHLLDQGRQRIATISGPLDMTAAQDRLTAYRETLKDTGRRSIVALGD
                     FTRISGAEAMRQLLDDDPQLDAVFAANDLMAIGALRTLREAGRRVPDDVAVIGFDDIEA
                     ALYTAPALTTIHSPMGEQAARTTRLLLDLITHGSADSVTLPTEIVVRESA"
     gene            5971..7707
                     /locus_tag="KFLA_RS12190"
                     /old_locus_tag="Kfla_2463"
     CDS             5971..7707
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020385992.1"
                     /locus_tag="KFLA_RS12190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2463"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_012920093.1"
                     /transl_table=11
                     /translation="MRRSRPSARLRAATLVALATSFVLALLVAPPADAADPLLSQGKPV
                     TASSSESVAFPASAAVDGDPGTRWSSSFADPQWLQVDLGQSVTISQVALSWESAYATAF
                     QIQTSADGSNWSSIYSTTAGAGGNQTLNVTGSGRYVRVLGTQRATQWGYSLWEFKVFGT
                     TGGGPGPDPGSRLLSYNKPGVASTQQHDSNCWECTPARAFDLDPASRWATATDSGWVDP
                     GWIYVDLGATAQIDKVVLQWDPASAKAYQLQVSNDATNWTTIYSTTTGPGFKQTLTVSG
                     TGRYVRMYGTQRNTPYGYSLWEFQVYGTGGAPTTPPAPPSDPANPPQLIWSDEFNGAAG
                     SKPDPAKWTIDPGTGPNNELEYYTNNNNAAMDGNGSLVMEARKEATPGSACPTDPLTGS
                     GTCQYTSHRMNTSGKFTTTYGKIEARVKVPKGAGLWPAFWMMGADFLTGRPWPYNGEID
                     ILEVLGKDVKTSYSTVHAPAYNGAGGVGGSYTLPDGADLSDDFHTWAAAWDSKGIVFSL
                     DGRPVVTLDKAQVEATRGPWVFDHPFYIILNLAVGGDWPGPPNAGTPFPARMLVDYVRV
                     YR"
     gene            7722..8990
                     /locus_tag="KFLA_RS12195"
                     /old_locus_tag="Kfla_2464"
     CDS             7722..8990
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020919.4"
                     /locus_tag="KFLA_RS12195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2464"
                     /product="DUF1996 domain-containing protein"
                     /protein_id="WP_012920094.1"
                     /transl_table=11
                     /translation="MNAPSRTVIRLGTLTVALLALLGAYLVSTSRPAQAAETLLSQGRP
                     AVASSVESGAFPASAAVDGNAGTRWASGFSDNQWLQVDLGSSQTFNRVVLRWEAAYARG
                     FQLQTSANASTWTTIHTTTNGTGGEQNLTVTGTGRYVRVLVTQRATQWGASLFEFQVYA
                     GTPSGGPIVRVAEFLADCPFTHRLPDDPIVFPNLPGASHMHSFFGATVTNAHTTVEDLV
                     NSPTSCNPATDKSSYWVPTLYKDNQPVEPTGTTFYYLGEGVRDDVIARIQPLPFGLRIV
                     AGNARATGPNDNTISRWSCLHAGDAGSGHDFITCPTGSMLESYLDFPQCWNGRDLDSPD
                     HKSHMAYPVNGDCPSTHPVPVPKLRQVLRYPVNGSTAGLRLASGGGFTMHGDFFNAWPQ
                     AEMERRVNDCIRPIIKCGADGRP"
     gene            9063..9608
                     /locus_tag="KFLA_RS12200"
                     /old_locus_tag="Kfla_2465"
     CDS             9063..9608
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020385989.1"
                     /locus_tag="KFLA_RS12200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2465"
                     /product="DUF305 domain-containing protein"
                     /protein_id="WP_012920095.1"
                     /transl_table=11
                     /translation="MRALGTALLLAGLLTGCGASAATEPPRPEPSVSSAFNTTDRAWLQ
                     LMVPMDEQLLRVLALADKQAADPAVRRLAASITVTHRAELAQLIALRDRSGAPSTNVHA
                     GHDMPGMMTGPEILALSNTKGAAFDRLLVKNLREHVDQSALVARSVATAGQEPAVKKLA
                     GSIQSTRAGQRKQLAALG"
     misc_feature    complement(9675..9691)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.88"
                     /tool="antismash"
     misc_feature    9774..9787
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.53"
                     /tool="antismash"
     misc_feature    complement(9833..9849)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            10001..12550
                     /gene="lanKC"
                     /locus_tag="KFLA_RS12205"
                     /old_locus_tag="Kfla_2466"
     CDS             10001..12550
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924048.1"
                     /locus_tag="KFLA_RS12205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2466"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_012920096.1"
                     /sec_met_domain="micKC (E-value: 9.1e-239, bitscore: 793.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.5e-16, bitscore: 58.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8e-05, bitscore: 20.3,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQYELYCLADRLFYDTPTNRGEQEPDFAACARPVPAGWQHDAGD
                     VWMHYAPADADLPAQGWKIHVSAGLDDADRTIAAVWDYCVGRGLAFKFLRSKPVLMMFN
                     SKSAFRGSSGKLVTIYPADEAQLELVLKELDGLLEGVQGPYILSDLRYADGPLFVRYGA
                     FVTRYCLSDSGERVYALTNGEGRLVPDVRGATFSIPPWVTLPSFLEPHLEARNAVTTNE
                     LAYVIENVIQFSNGGGVYLGHHRDTAEKVVLKEGRPLAGLDALGRDAVARVGHERDILQ
                     RLAGLDVVPAVRDYFQLGDHHFLVQEFIDSNSLQRLIVGRYPLTRPDASAEQRTAYAEW
                     ALGTLARIEQAVAALHERGVVFNDLHPDNILIDADDRLVLIDFEVATLATEQARSALAH
                     PGFAAPPDRHGVDVDRYALACLTLGLFAPQATMLLGLHPAKVNQLADLISETFQVPRAT
                     IAPAAGTVLGDRPALQADPPLPGKAPWQDLRSAITKAIAASATPQRDDRLFPGDIAQFE
                     PGGGINLAYGAAGVLYALDRCGAGRFPEYEDWLRRQTRDSAAVPGLYNGLHGVALVLHE
                     LGHHQDGLDALDRGRTQPAEVLELGLYSGLAGIGLSLLHFGAEPAALAAATRIVDEVAD
                     RLGGPEDVAELSGDGRPRAGLMFGSSGPALLFLHAYERSGDTGLLDLAKIALQQDLRRC
                     TADQYGMLQVNQGWRTLPYLEEGSAGIALVLDRYLRHRPDDELATALEPLRKVTRCGYF
                     VQPGLFMGRAGVLLAAAQLEPSASEQLIAGLGWHSLPYGDGLAFPGNQLLRLSMDVATG
                     SAGVLLALGAALHEQPAALPFLEPGPGFGSYQRREEV"
     gene            12554..12688
                     /locus_tag="KFLA_RS37060"
                     /old_locus_tag="Kfla_2467"
     CDS             12554..12688
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924049.1"
                     /locus_tag="KFLA_RS37060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2467"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_012920097.1"
                     /transl_table=11
                     /translation="MALLDLQGLEAPTGGGGGGGGGSTLTVLGCGSAKPSNLSLLLCH"
     CDS_motif       12554..12607
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGLEAPTGGGGG"
                     /locus_tag="KFLA_RS37060_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12608..12688
                     /prepeptide="core"
                     /locus_tag="KFLA_RS37060_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.70"
                     /molecular_weight="2334.7"
                     /monoisotopic_mass="2333.2"
                     /core_sequence="GGGGSTLTVLGCGSAKPSNLSLLLCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGLEAPTGGGGG"
                     /leader_location="[12553:12607](+)"
                     /alternative_weights="2352.7"
                     /alternative_weights="2370.7"
                     /alternative_weights="2388.7"
                     /alternative_weights="2406.8"
     gene            12761..14740
                     /locus_tag="KFLA_RS12210"
                     /old_locus_tag="Kfla_2468"
     CDS             12761..14740
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391577.1"
                     /locus_tag="KFLA_RS12210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2468"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_012920098.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.1e-49, bitscore:
                     167.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKPDLSYPDAERLAGAEFLHGHAVADPYRWLEDATDARTQAWQA
                     AQDELWLTQAAGLPGRYRFRARVAALSAVGTTSTPTWRGTRQFFVRRSPGQEHPALYVA
                     DPGKPERSLIDPTRHDSSGHTTLDRWQPSPDGRLVAFQLSRGDEQSVLHVLDVGTGEVV
                     DEPIDRCRYSPVGWLPDSKAFYFVRSRRLWLHRIGRADDVQVLPEEAAYGLEMSADGRW
                     LTISAAVADRNDVWLVDVSRPDFVPVVVQRGVDARSAPAVGPDGRLYVVTTLGAPSGRI
                     CVADPHRPGHEHWTELVGEQPGAPLSHLALLDGVLLVGRTRHAASELFAHDPSTGECLR
                     EVPLPGLGTLGELSTRPEGGQEAWFSYTDSVTPPGVHRYDARSGLVTPWTSDSRVVTDV
                     EARQVTYHSRDGTPLRMLVAGRPGAGRPRPTVLYGYGGFGLSLTPTYSAFALAWVEAGG
                     LFVTANLRGGGEQGDAWHRAGVLDGKQSVIDDFLAAAESLVAGGWTTPDRLGICGESNG
                     GLLVGAALTQRPDLFAAAVCSAPVLDMVRYQRSGLGQAWVSEYGSADDPAQLATLLAYS
                     PYHRVAAMDYPAVLLTIFGADTRVDPLHARKMCAALQHATTGSRPILLRYEHDAGHLPA
                     GVSRGIGLAADLLAFLACHTGLRP"
     gene            14737..16389
                     /locus_tag="KFLA_RS12215"
                     /old_locus_tag="Kfla_2469"
     CDS             14737..16389
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391576.1"
                     /locus_tag="KFLA_RS12215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2469"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_012920099.1"
                     /transl_table=11
                     /translation="MTTFGAVLRHGRGWLPLIGAAALLGSLTVLALPTVLGRAVDAVVT
                     EGPAGRWVVVACCLIAIGVACDLVEVVAGTACVAGTTAWLRNRLVRHVLASGPEGTSKF
                     DTGDLVTRVSSNAHDAALAGPATVTAVAAAVPPVGSLVLLAVIDPWLAAAFLAGVLLVG
                     VVLWAFTRRTAEISLAYQKTQGRIAAALTEALAGIRTIVSAGTVLREERRILRPLPQLH
                     DQGLRTWRVLARSGAQAAVAGPLVLIAVLAVGGIQLVNGRITPGEYFAAAQYAVIGAGL
                     GSLTGVLGELARARAGINRAAEVTGVAPVAYGTLSLPAGPGRLTFDDVVVRAGDRLLLD
                     RVNLDLPGGAAVAVVGPSGAGKSVLAAVAGRLRDPDSGQVQLDGMPLAGLSHRALRRAV
                     KCAFERPALVGSTVGEAVSVGSVPSVPLLAAARATHVHDFVSRMPAGYRTPLAEAPLSG
                     GEAQRLGLARAWTADRLLILDDATSSLDTATELQISKTLMGDRQRRTRLIVTHRAATAA
                     RADLVVWLDRGRVRGVGPHYELWADPAYREVFG"
     gene            16386..18101
                     /locus_tag="KFLA_RS12220"
                     /old_locus_tag="Kfla_2470"
     CDS             16386..18101
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020391575.1"
                     /locus_tag="KFLA_RS12220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2470"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_012920100.1"
                     /transl_table=11
                     /translation="MKRELQYAVGAVRRRSAVLLAAWSVPEILPTACYGLAVAHAADAF
                     LGGRVETGLAWLGGLLAAAVLGAVGARQVYRRLGELVEPVRDDLVRKVVSGALRTACAD
                     GAVARLNRQVEIVRDTFAGLVLVVRSFAVTVIGVVVGLLSLDPLVAALVVPPFLLGFLL
                     SFGVLGLAATRVRASLRADEDLTTSAGMAFAGVRDVAATGAEGFAAGLVGVPIAAHAAA
                     ERSLAKVAALRTLCFAVGGWLPLVVLLAAAPWLTDRGVSTGTLLGGMTYVLLGLQPALN
                     TVMSALGDSGLRYVVTLGRVLDMSEVAEPRSLGQLPTGHQVRLRRVSFAYGPDAAPVLH
                     DLDLVVGESDHLAVVGPSGIGKSTLARLICGLLPPTDGKILLGGVPPAALLPTELTGSR
                     VLIPQEAYVFTGTILANLVYLRPDATEAQVRAATEAVGAAGLVDRLGGPATVIRPSDLS
                     AGERQLLALARAYLSPAPLAVLDEATCHLDPEAERIAEEAFANRRGSLVVVAHRISSAV
                     RARRVLVLDGSRAAIGNHTSLLATSPLYADLVGHWAGPDVVRTELAEDQIQPAS"
     gene            complement(18080..18706)
                     /locus_tag="KFLA_RS12225"
                     /old_locus_tag="Kfla_2471"
     CDS             complement(18080..18706)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012924053.1"
                     /locus_tag="KFLA_RS12225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2471"
                     /product="response regulator transcription factor"
                     /protein_id="WP_012920101.1"
                     /transl_table=11
                     /translation="MIRQGGGEVIRVAIGHRGTLVRGALAAVLGRESDLKVVAECARAD
                     EVLEVSGGPEVVVLDPLLPGAIGMEELCGRLEGYALLMLIERDDGGSISLALAAAKQSA
                     KVGVMTTDASPDDLVDAVREVADGRPVFDVSLALAALRAGDNPLTERECEVLRLIGTGA
                     TAQEVAQILCLSPGTVRNYLSRILSKTGARSRIEAIRKAQDAGWI"
     gene            complement(18866..20089)
                     /locus_tag="KFLA_RS12230"
                     /old_locus_tag="Kfla_2472"
     CDS             complement(18866..20089)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="KFLA_RS12230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2472"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_012920102.1"
                     /transl_table=11
                     /translation="MQKVLISGASVAGPVLAYWLRQYGFRPTVVERTSAGRHGLGGHAV
                     DLFAAAVEITARMGLADRIHEARTRTRWLSMERYGKPPVDVDLDKLSAGLSDQHVEILR
                     GELTSILYDATRAGVDYRFGDSIASLHDDGDGVDVTFEQAPPERFDLVIGADGMHSTVR
                     RLVFGPEQQFRRPLGGYLGVYSLPNSFGLDNRMLTHLSVDRLVGVYGVHQTGQARATFL
                     FRTKEELGDDHRDKERQKQLLRDQFRGHGWKVPQLLEHLDAADDFYFDSITQITLEDWH
                     RGRVALVGDAGFCPGPAVGGGTSLAVVSAYVLAGELAAARSDLLSGLRNYQRQVRDVVQ
                     QSRRIGPKLMRSIIPASPTAVRLTPAATAVLIRLPERVQRFVWARSGFGKVLSSVQLPD
                     YRDLVRTP"
     gene            20187..20759
                     /locus_tag="KFLA_RS12235"
                     /old_locus_tag="Kfla_2473"
     CDS             20187..20759
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="KFLA_RS12235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2473"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_012920103.1"
                     /transl_table=11
                     /translation="MPRARSGDTKARIQAVALELFASKGLQQTSLRDIADQLGMTKPAL
                     YYHFASRDELVRSLAIPLIDDMTAFLAGLEASPADPRELLGAYFDVTYRHRVLLQVAIR
                     DLSVLQQMDLTDHVFDWRRRIVALLIGPSPSLEHQVRGMVALGGLSDCTVAFEDVDVDE
                     LRTAAVAAAYDALRPGVQGMSAQGMAP"
     gene            complement(20756..21064)
                     /locus_tag="KFLA_RS12240"
                     /old_locus_tag="Kfla_2474"
     CDS             complement(20756..21064)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020385988.1"
                     /locus_tag="KFLA_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Kfla_2474"
                     /product="DUF6703 family protein"
                     /protein_id="WP_012920104.1"
                     /transl_table=11
                     /translation="MSTSSSQPVSPLRQRVTKASYPVVAKLHAMPKLTLPAITLALALL
                     GVFTPVAIAVPALIVLALLLAWLGFLSWPVVTNGQRAVRVFTVLVIVLFAVSRIAGG"
     gene            21132..21635
                     /locus_tag="KFLA_RS12245"
                     /old_locus_tag="Kfla_2475"
     CDS             21132..21635
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KFLA_RS12245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Kfla_2475"
                     /product="hypothetical protein"
                     /protein_id="WP_012920105.1"
                     /transl_table=11
                     /translation="MTALPSVAAVRADLPAVLTRFRTGDTHAFSFGDGVPEAVLLTYDE
                     FEDLGGETKFAVGDEVLEPAALAAQLPALLTTLRAGSAIPVVWGTDGEPEAVLLSTSAY
                     RTLRGDDEPPAGVPDDPTQRTYPTEPLPTSRPFDLDEFAEGDPFTQELLREIRADRQSP
                     DDKR"
     gene            21622..22302
                     /locus_tag="KFLA_RS12250"
                     /old_locus_tag="Kfla_2476"
     CDS             21622..22302
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KFLA_RS12250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Kfla_2476"
                     /product="hypothetical protein"
                     /protein_id="WP_012920106.1"
                     /transl_table=11
                     /translation="MTSAERQRYLLEASPQFALDVKLLQARAKADPARHLHLYREVLRL
                     IEDLRDGVSDGHHALGYEAGKGDLRDCVTAYVAADPQAKANHRLVFRELGPAAPGGLPR
                     RELLAVKPRQGTGNVYEHVCARLGRHPADRQPGLNRFGDRAPGAKASQAQRQAELDTKR
                     AIAHAWAGQMPLASSRPLAPPGTGQRAGPSVPSPSRARTAGAGRAASGPGRPSGTGWPP
                     PRDR"
ORIGIN
        1 cgccgctggc cttgccgcgg gcccggatca gctcgatcgc cgtcgctccg gcgatcgcca
       61 ccaggatcgc cgtcagggcc ggggcggtcc cggtgagcag cccgagcgcg accccggtga
      121 tcgcgatgtg gccgatcccg tcccccatca gcgacaaccg gcgctgcacc aggtacgtac
      181 cgatcgccgg cgccgacaac ccggtcagca gcccagcgat caacgcccgc tgcatgaact
      241 cgagttcgaa aagggtcatg tcagccatcc cggttcgtct tccaccgggt gggggtggac
      301 gtgggcgtgc gtctgcgagg cgtgcggcgg gccgtcgtac acgatccggc cgcggcgcag
      361 cacgatcgag cggtcgatca gcgcgtccat cgggccgagg tcgtggctga ccatgatcac
      421 ggtcgtgccg cgggcgacgc gttcgcggat cgcgtcggcg aagatgtcct ggctggccag
      481 gtcgaccccg gcggtcggct cgtcgagcac gagcagctcg gggtcggaga cgagcgcgcg
      541 ggcgatcagc acccgctgct gctgcccgcc ggacaactcg gcgacggcgt ccttgcgccg
      601 gtcggccatg tcgaccagct cgagcgaacg gtcgacggca gcgcggccgg cagcggtcaa
      661 cgggcggaac cagcgccgct tcgacagcag gccggacgtg accacctcgg ccacggtcgc
      721 cggtacgccg ccggccgcgg tgatccgctg cggcacgtac ccgatccggc tccactggcg
      781 gaaccggggg accggcgtgc cgaacaggcg gacctcgccg cgggcggccg gcagcaggcc
      841 gacgatcgtc cggaccaggg tggacttgcc ggagccgttg gcaccgagca cggcgaccac
      901 ctcacccggc cggatctgca ggtcgatgcc gcgcagcacg agccggccgc ccaggtccac
      961 cgacagatcg gcgacctgga cggccttcgg tacggcggca ccgcccgcgg cccgctcggg
     1021 gccacggacg gtggaggggt cgggtgacgt cacgcgcagc tgttcgcctt ccggagctcg
     1081 gagaggttct cccgcatcag ggtcaggtag gtctcctgcg agttcgcgtc cgacaagccc
     1141 tcgatcgggc tcagcaccgc ggtctgcacg cgcaggtcac gggcgatcga ctgggccacc
     1201 ttcgggctga cgagctcctc gtagaagatc gtggtgatct gctgcttgcg cacgatgtcc
     1261 tggacctcct tgatccgctg cggggccggc tcggcgtcgg gcgtgaaccc ggcgatgccg
     1321 accatctgca gaccgtaccg cttcgcgagg taggcgaacg cctcgtgact cgtcacgaac
     1381 gtcttcagtt tgcacgactg cagaccggtc ttgtactcgg tgtcgagctt ggtgacctcg
     1441 tcgaccaggg ccttgccgcg ctcctggtaa ccgtccgcgt gcgcggcgtc gacctcggcc
     1501 agcttgtcgg tgacggcctg cacgaccgcg gcgtaccgga ccgggtcgag ccagaagtgc
     1561 gggtcgagct cctccgcgcc gccctcttcc tcgtgcttgt ccgtgccggc ttcttccgcg
     1621 tgctcctcct cgtgctcgaa gtgagcgccg gtggcctcca gggtggccgc cggggcgacg
     1681 tcgaagccgg cctgctcggc gttctgcgcg acggcttcgt cgacggccgg ctgcaggccc
     1741 ttctcgaaca gcaccagctt cgcgtcggtg atgctgccga cctgcttggg agtgagctcg
     1801 aggtcgtgcg gctcgacgcc gggcgcggtg agcgtggtca cctcgaccgc gtcacccccc
     1861 acctgctggg cgatgaactg gaggggatag aacgaagcga ccacgtcgag cttgtcaccg
     1921 ctaccgccgg agctgtcggt ggcgtcgcca ccgcaacctg caagagtgag tacggccaag
     1981 gcggcgaagc cggcggtgac agcacgaaaa ccagatctca tgacaatcat tttcatttaa
     2041 tcggagatgg ttgtcaaaac agggagtgaa accgatggcc aggcgggcgg cagggcgcag
     2101 gcgagccgac accaagggga accggcgccg ccggatcagc attcccaccg gtcacgggca
     2161 cggccacggc cacggcggct gggcggacag cggggagcac gtgctcgaca cctcggtggt
     2221 ggaccgcgac gcggtggtcg cccgccgggt ccgggtcgtg gtggcggcgc tgctggtgcc
     2281 gctgatcgcc gccgcggtga tcgcgatggt ggtgatgtgg ccgggcggcg acctcgtcgt
     2341 ccagtcggcg cactccaccg gcgccggtgg cacggtgcag aagctggagc cgtgcccgga
     2401 gacgcccgcc gactgcgacc aggcgacggt ccggatcgac tccggtccgg aggccgacaa
     2461 gggccgggag gttccggtcg aggtcccgaa gggcaagcag gcggcgattc cgatcgaggt
     2521 cggcgacaag gtcctgctcg gcgttcagga cggtgcaccg ctgaccgagc gctaccagta
     2581 cgtcgaccac gaccgcggcc ggccgctgct gctgctggcc gggatcttcg ccgtcgcggt
     2641 ggtggtgctg tcgcgctggc ggggtttcgc ggcgctgatc gccttgggcg tcaccggggt
     2701 cacgctgacg cagttcatca tgccggcgat tctcaaaggc tcgaacccgc tgctggtcgc
     2761 ggtggtcgga ggcgcggtga tcatggtgat cgcgctcttc ctcacccacg gcgtcaacgc
     2821 gcagtcctcg gtggcgctgg ccggcacgat cgccgcgctc gggctcaccg cgttcctggg
     2881 ctgggcgttc gtgaagttca gcgatctgtc cggcctgggc tccgagggcg cctcggtggt
     2941 gaaggcctac gtgcccgacc tcgacctggc cggcctgctg gtcgccggca tcgtcatcgg
     3001 cgcgctcggc gtgctcgacg acgtcacggt cacccaggcc agtgccgtct gggagctgtc
     3061 cgcggccaac ccggcggcga gccgggccgc cctgttcggc gcgggcctgc ggatcggccg
     3121 ggcgcacgtc gcctcggtgg tgaacaccct cgtgctcgcg tacgccggcg cagccctgcc
     3181 gatcctgatg gtcttcgcga tcagtgggac gaaggctggt tacctgatct ccaccgagat
     3241 ggtcgccatc gaggtcgtgc gcggcctggt cggcagcctg gggctgatcg cggccgtgcc
     3301 gttgacgacg gccttggcgg cgatggcggt ggcggaccgc tcgcgggacc tggtcgcggg
     3361 accggagcgg ctggcctcgg gcgaggagaa cgccgatccg gtggcggagc cgcgcgagtc
     3421 gtgaccctgc gctgactccg cgtcaacagg tgcttccctc ctgccggaat gcactctaaa
     3481 gtagccgctc tgtcacggac tgtccgcccc agactacttt ccgtggcacg acggtgagga
     3541 gtcgcgcatg cgtcgacgca ggggttccgc cggtcgctcg gcgctgcggg gcgcccggtc
     3601 atgaggttcc ggcatcccga cggatcgacc gttcacctcg cgtactccac ccacgtgcat
     3661 cccgccgagg atctcgacgg cgtgatcgcc cagctcgacg ggtgctcgtc gctggtccgc
     3721 aaagcactcg acgtcccggt tctcggcatc ggtctgtggc tcgcgcacga actggccgac
     3781 cagctcgcga actccccggc cgctctgaac cgcctacgtc gagcgctcgg ccggaacgcc
     3841 ctggaggtcg tgatgctgaa cggcctcccg tacgccgact tccgggccaa ggtggtcggc
     3901 cagcaggtgt acctcccgga ctggacccag cccgagcgtc tgcgctacac cctcgacctg
     3961 atcgaggtgc tggccaagct gatgcccacc gacgcggcgt acgggtcgat ctcgacgccg
     4021 ccgctggcct ggcgtttccc gtggtcgcgc cggcgggacg cggtcgcgcg gcaggcgttc
     4081 gaccggctcc aggtccggct cgcccaggtc gggacgaacg ccggccggcg gatccggatc
     4141 gccctcgaac ccgagcccgg ctgcgtgctc gagatggttc cgcaggccac ccactggctc
     4201 accccgtacg ccggttcggc gctgatcggg ctctgcctgg acacctgtca cctggcggtc
     4261 cagttcgagg acccggccgc gagcttcgcc gtcgcgcagg ccgccggggt ggagatcgtg
     4321 cgaagccagc tgtcagccgc cctgcacgtc cccgatcccc gcgatgagga tgcgcaacgg
     4381 ttgctgaacg agttcgccga gcccaagttc ctgcaccaga cccgcgagtg gggcggcccg
     4441 ggcgtcgaca acctcgacca ggccgaccag ctctccggcc atgccgcctg gcgggtgcac
     4501 ttccacgtcc cggtccacgc gccgcccaga gcgccgttga ccagcacgac cggcgtactc
     4561 gaggactgcc tgaaccacct ggtcggcggt ccccatccac tgacgcacca cctggagtcg
     4621 gaaacctacg cctggtcgat cctgcccgac ggtccgacga accagcagga gctggccgag
     4681 ggcatcgccg cggagctgag ctggctcagg cagcggatcg tcgcgcacgg cctggaagag
     4741 ctcacctgac ctgttgctac cagcaactgc ctacgccgat tcgcgcacga cgatctcggt
     4801 cggcagggtg accgagtccg cgctgccgtg ggtgatcagg tcgagcagca gccgggtcgt
     4861 tcgggccgcc tgctcgccca tcgggctgtg gatcgtggtc agcgccggtg cggtgtagag
     4921 cgcggcctcg atgtcgtcga acccgatcac cgcgacgtcg tcgggcaccc ggcggccggc
     4981 ctcgcgcagc gtgcgcagcg cgccgatcgc catcaggtcg ttggcggcga acaccgcgtc
     5041 cagctgggga tcgtcgtcca gcagctgccg catcgcctcc gccccggaga tccgggtgaa
     5101 gtcgccgagg gcaacgatcg atcgccgccc ggtgtccttc agcgtctccc ggtacgccgt
     5161 cagccggtcc tgcgcggcgg tcatgtcgag cggcccggag atcgtcgcga tccgctgccg
     5221 tccctggtcc agcaggtgcc gcacggccag ccgggccccg ccgaggttgt cgttgtcgac
     5281 ccacggcatc agccccggcg tggacagccg tccgtgcgac acgatcggca gcccggtccg
     5341 ggccagcacc gcgggcaacg ggtcggcgcc gtccatcgag accagcatcg cgccgtcgac
     5401 gtggccggcg gcgaggtact gctcgacgcg cttgcggctc tcgtcggacc cggcgagcac
     5461 gagagagacc tgcttgccgg ccgcctcgag ctgccggctg gcggcgcgaa ccaccatcgc
     5521 gaacatcggg tcgtcggagg ccagcccggc cggcgggtcg gagacgatga tcgcgatcgt
     5581 gttcgtcttc tgggtgacca ggttgcgggc cgcgccgttc ggcacgtagc cgagctcggt
     5641 gaccgcggcc atcacgatct gccggatctc cggcgcgacc gtcggctcgc cgttgatcac
     5701 ccgggacacg ctcgacttgg agacgccggc ccgggccgcg accgcgtgca gcgtcggtcg
     5761 tctcacgggc accccctcgg cggtgacagg ggagcgttcc ccacgcacga gcatcccggc
     5821 ggttccggaa ccttgtcaag caccgcgcgg ccgggcgcac ccccggcgac gggttccggg
     5881 cgagcccttg acaccgttcc cggagcaggc aactctcaga ctcagggaac gttccctcgc
     5941 actcttcctg cccgccccct ggagatgccc atgcgtagat cccgcccttc cgcgcgcctc
     6001 agagcagcaa ccctggtcgc gctcgcgacg agcttcgtgc tcgccctcct ggtcgccccg
     6061 cccgcggacg ccgccgaccc gctgctgtcc caaggcaagc cggtgaccgc gtcctcgtcc
     6121 gagagcgtcg ccttccctgc gtccgcggcc gtcgacggtg accccggcac ccggtggtca
     6181 agctccttcg ccgacccgca gtggctgcag gtcgacctcg gtcagtccgt caccatcagc
     6241 caggtcgcgc tcagctggga gtcggcgtac gcgaccgcat tccagatcca gacctctgcc
     6301 gacggcagca actggagctc gatctacagc acgaccgccg gtgccggtgg caaccagact
     6361 ctcaacgtca ccggctcagg ccgttacgtg cgggtgctcg gtactcagcg ggcgacccag
     6421 tggggctact cgctgtggga gttcaaggtg ttcgggacca ctggtggtgg ccccggcccc
     6481 gatccgggca gccggctgct ctcgtacaac aagccgggcg tcgcctcgac gcagcagcac
     6541 gacagcaact gctgggagtg cacgccggcc cgtgcgttcg acctcgaccc cgccagccgc
     6601 tgggccaccg cgaccgactc cggctgggtc gacccgggct ggatctacgt cgacctcggc
     6661 gcgaccgcgc agatcgacaa ggtcgtgctg cagtgggacc cggcctcggc gaaggcgtac
     6721 cagctgcagg tctcgaacga cgcgaccaac tggaccacca tctactcgac gaccaccggc
     6781 cccggtttca agcagacgct gaccgtcagc gggaccggcc ggtacgtccg gatgtacggc
     6841 acgcagcgga acacgccgta cgggtactcg ctgtgggagt tccaggtcta cggcaccgga
     6901 ggtgcgccga ccacgccgcc ggccccgccc agtgacccgg cgaacccgcc gcagctgatc
     6961 tggtccgacg agttcaacgg cgcggccggg tccaagcccg acccggcgaa gtggacgatc
     7021 gatcccggca ccggcccgaa caacgagctg gagtactaca cgaacaacaa caacgccgcg
     7081 atggacggca acggcagcct ggtgatggag gctcgcaagg aggcgacgcc cggctcggcc
     7141 tgcccgaccg acccgctgac cggcagcggc acctgccagt acacctcgca ccggatgaac
     7201 accagcggca agttcaccac cacctacggc aagatcgagg cccgggtgaa ggtgccgaag
     7261 ggcgccgggc tgtggccggc gttctggatg atgggcgcgg acttcctgac cggccgtccg
     7321 tggccgtaca acggtgagat cgacatcctc gaggtgctcg gcaaggacgt gaagacctcg
     7381 tactccaccg tgcacgcccc ggcctacaac ggcgccggcg gagtcggcgg ctcgtacacg
     7441 ttgccggacg gggccgatct gtcggacgac ttccacacct gggcggccgc ctgggacagc
     7501 aagggcatcg tcttcagcct cgacggccgg cccgtcgtga cgctggacaa agcccaggtg
     7561 gaggcgaccc ggggtccgtg ggtcttcgac cacccgttct acatcatcct caacctcgcc
     7621 gtcggcggtg actggcccgg cccgccgaac gccggtacgc cgttcccggc ccgcatgctc
     7681 gtcgactacg tgcgcgtcta ccggtgaagc gaggagctcc gatgaacgca ccatctcgta
     7741 ccgtcatccg gctcggcacg ctcaccgtcg ccctgctggc gctgctcggg gcctacctgg
     7801 tcagcaccag caggcccgcg caggccgccg aaaccctgct gtcccagggc cgtccggccg
     7861 ttgcctcgtc ggtggagagc ggcgccttcc cggcgtcggc cgccgtcgac ggcaacgccg
     7921 ggacccgttg ggccagcggc ttctccgaca accagtggct gcaggtcgac ctcggctcca
     7981 gccagacctt caaccgggtc gtgctgcgct gggaggcggc gtacgcgcgc ggcttccagc
     8041 tgcagacgtc cgcgaacgcg agcacctgga ccacgatcca caccaccacc aacggcaccg
     8101 gcggtgagca gaacctgacc gtcaccggca ccggccggta cgtgcgggtg ctggtcaccc
     8161 agcgggccac ccagtgggga gcctcgctgt tcgagttcca ggtgtacgcc gggacgccga
     8221 gtggcgggcc gatcgtccgg gtggccgagt tcctcgcgga ctgcccgttc acgcaccggc
     8281 tgcccgacga cccgatcgtg ttcccgaacc tgccgggcgc ttcgcacatg cacagcttct
     8341 tcggtgccac cgtgacgaac gcgcacacca ccgtcgagga cctggtgaac tcgccgacgt
     8401 cctgcaaccc ggccacggac aagtcgtcgt actgggtgcc gacgctgtac aaggacaacc
     8461 agccggtcga accgaccggg accaccttct actacctggg ggagggcgtt cgcgacgacg
     8521 tcatcgcccg catccagccg ctgccgttcg ggctgcgcat cgtggccggt aacgcacggg
     8581 cgaccgggcc gaacgacaac accatctccc gctggtcctg cctgcacgcc ggggacgccg
     8641 gctccgggca cgacttcatc acctgcccga ccgggtcgat gctggagtcc tacctggact
     8701 tcccgcagtg ctggaacggg cgggacctgg actcaccgga ccacaagagc cacatggcgt
     8761 acccggtgaa cggcgactgc ccgtccaccc acccggtgcc ggtgccgaag ctgcgccagg
     8821 tactgcgcta cccggtgaac ggctcgacgg ccgggctgcg gctcgcgtcc ggtggcgggt
     8881 tcaccatgca cggcgacttc ttcaacgcct ggccgcaggc cgagatggag cgccgcgtca
     8941 acgactgcat ccgccccatc atcaagtgcg gcgccgacgg gcgcccgtga ccctgtgaac
     9001 cgcgggggca ggtctcgtcc cagacctgcc cccgcacctg cctgtcacga aggagttcga
     9061 gcatgagagc tctcggtact gcgctgttgc tggctggact gctcaccggc tgtggggcgt
     9121 cggccgccac ggagccgcct cggccggagc cgtcggtctc ctccgccttc aacaccaccg
     9181 atcgcgcgtg gctgcagctg atggtgccga tggacgagca actgctccgc gtccttgcac
     9241 tcgccgacaa gcaggccgct gatcccgccg tacgccggct ggccgcgagc atcaccgtga
     9301 cccaccgggc cgagctagcc cagctgatcg ccctgcgcga ccgctccgga gcgccgagca
     9361 ccaacgtgca cgcgggccac gacatgcccg gcatgatgac cggtccggag atccttgccc
     9421 tgagcaacac aaagggcgcc gccttcgacc ggctgctggt gaaaaacctc cgggagcacg
     9481 tggaccagtc cgcgctggtc gccaggagcg tcgccacggc cggtcaggaa ccggcggtca
     9541 agaagctggc cggcagcatc cagagcaccc gagccggcca gcgcaaacaa ctcgccgcgc
     9601 tcggctgact tcggctggtt ccagtccgcg cgggcgcctt gctcgctgtc gctcgctcgg
     9661 tgcctgctcc catccgcccg gccattgtgc gtgcgcgtgc tgtcgcccgc ttcgttctag
     9721 tgcaggcggt tcggggtcga gccggcctga ttcgcccgac gatcgccacc atgcattcgt
     9781 ttgtttcggc gcagttccaa cgcttacttc attcgccgcc cacgctctcc actgcccaca
     9841 tcgtcggcaa ctcgccgaat cgtctactga ccggccggtt cggagatacc caggcgtagc
     9901 gcctgagtta ttcacacggc ggtggtgacg cccggcacta cgcagcggcc tgggacggcg
     9961 acaccatgtg acgacgagac cggatcatgg ggaggccgaa gtggaacagt acgagctgta
    10021 ctgcttggcc gatcggctgt tctacgacac cccgaccaac cgtggcgagc aggagccgga
    10081 cttcgcggcc tgtgcccgtc cggtgccggc aggctggcag cacgatgccg gtgacgtctg
    10141 gatgcactac gcgccggccg acgccgacct gccggcccag ggctggaaga tccatgtctc
    10201 ggccgggctg gacgacgccg accggacgat cgcggcggtc tgggactact gcgtcggtcg
    10261 cgggctggcg ttcaagttcc tgcgcagcaa gcccgtcctg atgatgttca actcgaagtc
    10321 ggccttccgt ggctccagcg gcaagctggt caccatctac ccggcggacg aggcgcagct
    10381 cgagctggtc ctgaaggagc tcgacggcct gctcgaaggt gtccagggcc cctacatcct
    10441 cagcgacctg cggtacgccg acggcccgct gttcgtccgg tacggcgcct tcgtcacccg
    10501 gtactgcctg tcggacagcg gcgagcgggt ctacgcgttg accaacggcg agggccggct
    10561 ggttccggac gttcgcggag ccaccttctc gatcccgccg tgggtgaccc tgccctcctt
    10621 cctggagccg cacctcgagg cccggaacgc cgtcaccacc aacgagttgg cgtacgtgat
    10681 cgagaacgtc atccagttct ccaacggcgg cggcgtctac ctcggccacc accgcgacac
    10741 cgcggagaag gtggtgctca aggagggccg cccgctggcc gggctggacg ctctcggccg
    10801 ggacgcggtg gcccgggtcg gccacgagcg cgacatcctc cagcgcctgg ccgggctgga
    10861 cgtcgtgccg gccgtccgcg actacttcca gctgggcgac caccacttcc tggtacagga
    10921 gttcatcgac tcgaactcgc tgcaacggct gatcgtcggg cgctacccgc tgacccggcc
    10981 ggatgcctcc gccgagcagc ggacggcgta cgccgagtgg gctttgggca cgctggcccg
    11041 gatcgagcag gcagtcgcag ccttgcacga gcgcggcgtg gtcttcaacg acctgcatcc
    11101 cgacaacatc ctgatcgacg ccgacgaccg gttggtgctc atcgacttcg aggtggccac
    11161 gctggccacc gagcaggccc ggtcggcgct cgcgcacccg ggtttcgccg ccccgccgga
    11221 ccgccacggc gtcgacgtgg accgctatgc gctggcctgc ctcacgctcg gactgttcgc
    11281 accgcaggcc accatgctgc tcgggctcca cccggccaag gtgaaccagc tggccgacct
    11341 gatcagcgag accttccagg tgccgagggc aacgatcgcg ccggcggccg gcacggtgct
    11401 cggcgaccgg ccggcgctgc aggccgaccc gccgctgccc ggcaaggcac cttggcagga
    11461 cctgcgctcg gccatcacca aggcgatcgc ggcgtccgcg acaccgcagc gggacgaccg
    11521 gctgttcccg ggagacatcg cacagttcga gcctgggggc gggatcaacc tggcgtacgg
    11581 ggcagcaggc gtgctgtacg ccctggaccg ctgcggtgcc ggccgcttcc cggagtacga
    11641 ggactggctg cgcaggcaga cccgggactc cgccgctgtg cccggtctct acaacgggct
    11701 gcacggagtc gctctggttc tgcacgagtt gggtcaccac caggacgggc tggatgccct
    11761 ggaccgtggc cgcacccagc ccgccgaagt gctggagctg ggcttgtact ccgggctcgc
    11821 cggcatcggg ctcagcctgc tgcacttcgg ggccgagccg gctgccctcg ccgccgccac
    11881 ccggatcgtg gacgaggtgg cagaccggct cggtggaccc gaggacgtcg cggagctcag
    11941 cggcgacggg cgtccgcgtg cgggcctgat gttcggctcg tccggtccgg ccctgctgtt
    12001 cctgcacgcc tacgagcgct ccggcgacac cggcctgctc gatctggcca agattgcgct
    12061 ccagcaggat ctacgccgct gcaccgccga ccagtacggc atgctccagg tcaatcaggg
    12121 gtggcgcacg ctgccctacc tggaagaggg ctcggcgggt atcgcgctgg tgctggaccg
    12181 ctatctgcgc caccggccgg acgacgaact cgcgacggct ctcgagccgc tgcggaaggt
    12241 cactcgctgc ggctacttcg ttcagcccgg tctgttcatg ggtcgcgccg gcgttctgct
    12301 cgcggcggcc cagctcgagc cgagcgcgtc ggagcagctg atcgccggac tgggctggca
    12361 ctcgctgccc tacggcgacg gactggcctt tcccggcaac cagttgctcc ggttgtcgat
    12421 ggatgtcgcc accggttcgg ccggcgttct gctggccctg ggtgccgcgc tgcacgagca
    12481 gccggcggcc ctcccgtttc tcgagcccgg tcccgggttc ggttcctacc agcgccgaga
    12541 ggaggtgtag acaatggcac ttctcgacct gcagggcctc gaagccccca ctgggggcgg
    12601 cgggggtggc ggtgggggca gcacgctgac cgttctcggc tgtggctccg ccaagccgag
    12661 caacctcagc cttctgctct gtcactgagg cgcgtaggtt ccgggcgagg ccccctgagc
    12721 tcgcccggaa ctgcggccgc caccgggaac caggagtccc gtgcggaaac ccgatctgag
    12781 ctatcccgac gccgagcggc tggccggcgc cgagttcctg cacggccacg cggtggcgga
    12841 tccgtaccgc tggctggaag acgccacgga tgcccggacg caggcctggc aagcggcaca
    12901 ggacgagctc tggctcaccc aggccgcagg gctaccgggc cgctaccgtt tccgggcccg
    12961 ggtcgccgca ctgagcgccg tcggcaccac cagtacgccg acctggcgcg gcacacggca
    13021 gttcttcgtc cgccggagtc ccggtcagga gcatccggcc ctgtacgtcg ccgaccccgg
    13081 taagcccgag cggtcgctga tcgacccgac ccgccacgac tcctccggcc acaccacgct
    13141 cgatcgctgg cagccttcgc cggacgggcg gctggtcgcc ttccagctgt cacgcggcga
    13201 cgagcagtcc gtactgcacg tactggacgt cggcacgggc gaggtcgtcg acgagccgat
    13261 cgaccggtgc cggtactccc cggtggggtg gctcccggac agcaaggcct tctacttcgt
    13321 tcgctcgcgc cggctgtggc tgcaccggat cggccgggcg gacgacgtgc aggtgctgcc
    13381 ggaggaagcg gcgtacgggc tggagatgag tgcggacggc aggtggctga ccatctccgc
    13441 cgcagttgcc gaccgcaacg atgtgtggct cgtcgacgtc agccggcccg acttcgttcc
    13501 agtggtggtg cagcgaggtg tcgacgcccg cagcgcgccc gccgtcggcc ccgacggccg
    13561 gctctacgtc gtgaccaccc tcggcgcacc gtccggccgg atctgcgtcg ccgatcccca
    13621 ccggcctggt catgagcact ggaccgagct tgtcggcgag cagccggggg cgccgctgag
    13681 ccacctggcg ctgctcgacg gggtgctgct cgtcggccgg acgcggcacg cggcgagcga
    13741 gctgttcgcc cacgatccgt cgactggtga gtgcctgcgt gaggtaccgc ttcccggtct
    13801 cggcacgctc ggcgagctca gcacccgccc ggagggtggc caggaagcgt ggttcagcta
    13861 caccgacagc gtcacgccgc ccggcgtcca tcggtacgac gcccgcagcg gcctggtgac
    13921 gccatggacc tcggactccc gggtggtgac cgacgtcgag gcgcgtcagg tcacgtacca
    13981 ctcccgtgac ggtacgccgc tccgcatgct ggtggccggc cggccaggcg ccggccgacc
    14041 ccgtcccacg gtcctctacg ggtacggcgg cttcgggttg tcgctcaccc ccacctactc
    14101 ggcgttcgcc ctggcctggg tggaagccgg cggcctgttc gtcacggcga acctgcgcgg
    14161 cggaggcgaa cagggcgacg cgtggcaccg ggccggtgtc ctggacggga agcagtcggt
    14221 catcgacgac ttcctcgccg cggccgagtc cctggtcgcc ggcggctgga cgacgcccga
    14281 ccggctcggt atctgcggcg agtccaacgg cggactgctg gtcggggcgg cactcaccca
    14341 gcgcccggac ctgttcgccg cggcggtctg ctcggcgccg gtgctcgaca tggttcgcta
    14401 ccagcggtcc ggtctcggcc aggcctgggt cagcgagtac ggctccgcgg acgacccggc
    14461 gcaactggcg acattgcttg cctactcgcc gtaccaccgg gtcgcagcga tggactatcc
    14521 ggccgtgctg ctgacgatct tcggggcgga cacgcgggtg gatccgctgc acgcacggaa
    14581 gatgtgtgcg gctctgcagc acgcgaccac cggttcacga ccgatcctgc tcaggtacga
    14641 gcacgacgcg gggcaccttc cggcgggcgt cagccgcggc atcgggttgg ctgcggacct
    14701 gctggcattc cttgcctgcc acaccgggtt gcgcccatga ccaccttcgg cgccgtactg
    14761 cgccacggac ggggttggct tccgctgatc ggggctgccg cgctgctggg cagtctgacc
    14821 gtgctggcct tgccgacggt gctggggagg gccgtcgatg ccgtcgtcac cgaagggccg
    14881 gccggccgtt gggtggtggt tgcctgctgc ctgatcgcga tcggtgtcgc ctgcgacctg
    14941 gtcgaggtgg ttgccggcac ggcctgtgtc gccggcacca cagcgtggct gcggaaccgg
    15001 ctggtccgcc acgtcctggc gtccggaccc gagggaacga gcaagttcga caccggagac
    15061 ctggtcaccc gggtgtcgag caacgcccac gacgcggcgc tggccggtcc tgccacggtg
    15121 actgcggtcg ccgcggccgt cccaccggtc ggcagtctgg tcctgctggc ggtgatcgac
    15181 ccgtggctgg ctgctgcttt tctggccggg gtcctgctcg tcggcgtggt gctgtgggcg
    15241 ttcactcggc ggaccgccga gatcagcctc gcctatcaga aaacccaggg ccggattgcc
    15301 gcagcactca ccgaggcact ggccggtatc cggaccatcg tgtccgccgg gaccgtgctg
    15361 cgcgaggagc gccggatcct gagaccgctg ccacaactgc acgaccaagg cctgcggacg
    15421 tggcgcgtcc tggcccgctc cggagcgcag gccgccgtgg cggggccgct ggtgctgatc
    15481 gccgtcctgg ccgtcggcgg catccagctg gtgaacggcc ggatcacgcc gggcgagtat
    15541 ttcgccgccg cccagtacgc cgtcatcggc gcgggcctgg gcagcctcac cggcgtactg
    15601 ggcgagctgg ccagggcccg ggccggaatc aaccgggccg cggaggtgac cggagtggcg
    15661 cctgttgctt acggcaccct ttcgctgccg gccggtcccg gccggctgac cttcgacgac
    15721 gtcgtcgtcc gggccggcga cagactgctg ctggaccggg tgaacctgga tctgcccggc
    15781 ggagccgccg tcgccgtggt gggaccgagc ggcgcgggca agtccgttct ggccgctgtc
    15841 gccggccggt tgcgcgaccc ggactccgga caggttcagc tcgacgggat gcccctcgcc
    15901 gggctgagcc accgcgccct gcggcgcgcg gtgaagtgcg cgttcgaacg acccgcgctg
    15961 gtcggctcga ccgtggggga ggcggtgtcg gtcggctccg tcccttcggt gccgctgctc
    16021 gcggcggccc gcgccaccca cgtgcacgac ttcgtcagcc ggatgccggc cggctaccgc
    16081 acaccgctcg ccgaggcgcc gttgtcgggc ggcgaggcgc aacggctcgg gctggccagg
    16141 gcctggaccg ccgaccgcct gctcatcctg gacgacgcca cctccagcct ggacaccgcg
    16201 accgagctgc agatcagcaa gacgctgatg ggcgaccggc agcgccgtac tcggttgatc
    16261 gtcacccatc gcgcggccac cgctgctcgg gctgacctgg tggtgtggct ggaccgcggc
    16321 cgggtccgcg gcgtcggccc gcactacgag ctgtgggcgg acccggcgta ccgcgaggtc
    16381 ttcggatgaa gcgcgaactg cagtacgcgg taggcgccgt acgccgtcgg tcggcggtgc
    16441 tgctggccgc ctggtcggtg ccggagatct tgccgacggc ctgctacggg ctcgccgtcg
    16501 ctcacgcggc ggacgcattt ctcggtgggc gggtggagac aggtctggcc tggctcggcg
    16561 gtctgcttgc ggccgcagta ctgggcgcgg tcggtgcacg ccaggtctac cgacggctcg
    16621 gtgaactggt tgagccggtg cgcgacgacc tggtccgcaa ggtggtgtcc ggcgcgctgc
    16681 gtacggcgtg cgccgacggg gccgtcgctc ggctgaaccg acaggtggag atcgtccgcg
    16741 acaccttcgc cgggcttgtc ctggtggtcc ggagcttcgc ggtgacggtg atcggggtgg
    16801 tcgtcgggct gctgtccctg gatccgctgg tggcggccct cgtcgtaccg ccgttcctgc
    16861 tgggcttcct gctgtcgttc ggtgtgctgg ggctggccgc gacccgggtc cgcgcgtcct
    16921 tgcgggccga cgaagatctg accacctcgg ccgggatggc ctttgcgggg gtgcgggacg
    16981 tcgcggcgac cggggccgag gggttcgcgg ccggcctggt cggcgtgccg atcgcggccc
    17041 acgccgcggc ggagcggtcg ctggcgaagg tcgcggcgct gcgaacgctc tgcttcgcgg
    17101 tcggcggctg gctgccgctg gtcgtcctgc tcgccgccgc gccctggctc accgaccgcg
    17161 gcgtgagcac cggaaccctg ctcggtggca tgacgtacgt gctgctggga cttcagccgg
    17221 cgctcaacac ggtgatgtcc gcgctcggcg acagcggtct gcgctacgtg gtcacactgg
    17281 gccgggtgct cgacatgagc gaggtcgcgg agccgcggtc gctcggccag ctgccgaccg
    17341 gtcatcaggt ccggctgcgg cgggtctcct tcgcctacgg cccggacgcc gcaccggtgc
    17401 tgcacgacct ggacctggtc gtcggggagt ccgaccacct cgcagtcgtc ggcccgagcg
    17461 gcatcggtaa gtcgacgctg gcacggctga tctgcgggct gctgccgccg acggacggca
    17521 agatactgct cggcggcgta ccgccggcgg ctctcctccc gaccgagctg accggctcgc
    17581 gggtcctcat tccgcaggag gcgtacgtct tcacgggcac gatcctggcc aacctggtgt
    17641 acctgcggcc ggacgccacc gaggcccagg tccgcgcggc gaccgaagcc gtgggtgccg
    17701 ccggcctggt cgatcgactg ggcggacccg cgaccgtcat cagaccgtcg gacctgtcgg
    17761 ccggggagcg ccagttgctc gcactggctc gggcctactt gtccccggcg ccgctggccg
    17821 tgctggacga agccacctgt cacctggacc cggaggcgga gcgcatcgcc gaggaggcct
    17881 tcgccaacag acgcggcagt ctcgtcgtcg ttgcgcaccg gatcagctcc gccgtacggg
    17941 cgcggcgcgt ccttgtcctg gacggcagcc gcgctgccat cggcaaccac accagcttgc
    18001 tcgcgaccag ccctctgtac gccgatctgg tcggtcactg ggccggtccg gacgtggtgc
    18061 ggaccgagtt ggccgaggat cagatccagc cggcgtcctg agccttgcga atcgcttcga
    18121 tccggcttct ggcgccggtc ttgctgagga tgcgggacag gtagttccgc acggtgcccg
    18181 ggctcaggca caggatctgc gccacctcct gcgcggtggc gccggtcccg atcagccgca
    18241 gaacctcgca ctcccgctcg gtcagcgggt tgtcaccggc tctcagcgcc gcgagcgcca
    18301 ggctgacgtc gaaaaccggc ctgccgtcgg cgacctcccg gacggcgtcg accaggtcgt
    18361 cgggcgacgc gtcggtggtc atcaccccga ccttcgccga ctgcttggcc gccgccagcg
    18421 ccagcgagat ggacccgccg tcgtcccgct cgatcagcat cagcagcgcg tagccctcga
    18481 gccggccgca gagctcctcc atcccgatcg cgcccggcag cagcggatcg agcaccacca
    18541 cctccggccc tccggacacc tccagcactt cgtcggcgcg agcgcactcc gcgaccacct
    18601 tcagatcgga ttccctgccg agcaccgcgg ccaacgcccc acgtaccagc gtgccgcggt
    18661 gaccgatggc aactcggatc acctctccgc ccccctggcg aatcaccttc gctgattccg
    18721 gaaaccgccg gtgacctaaa gcggccgaat ttctggaatc ggtcaccgac agtctccaac
    18781 gagacgtccg cgatgtcacc agtccaggcc gtcccatctc gaccgactgc tcgcacgggc
    18841 cgctgggccg gcggggccag gccggtcagg gcgtccggac gaggtcccgg tagtccggca
    18901 gctgcaccga gctgagcacc ttgccgaaac cgctgcgagc ccacacgaag cgctgcaccc
    18961 gctccggcag ccgaatcagc acggctgtcg cggccggtgt cagccgaacg gcggtaggac
    19021 tcgccgggat gatcgagcgc atcagcttcg gcccgatccg acggctctgc tgcacgacgt
    19081 cccgcacctg ccgctggtag ttccgcagcc ccgacagcag atcactgcgc gccgcggcca
    19141 actcacccgc cagcacgtac gccgagacga cggccaggct ggtcccgccg ccgaccgccg
    19201 gtcccgggca gaagcccgcg tcgccgacca gcgccacccg gccccggtgc cagtcctcga
    19261 gagtgatctg cgtgatcgag tcgaagtaga agtcgtctgc ggcatcgagg tgttccagca
    19321 gttgcggcac cttccagccg tggccccgga actggtcacg cagcaactgc ttctgccgtt
    19381 ccttgtcgcg gtggtcgtcg ccgagctcct ccttcgtccg gaacaggaag gtcgcacggg
    19441 cctggccggt ctggtgcacg ccgtacacgc cgacgagccg gtcgacgctg agatgggtca
    19501 gcatccggtt gtcgaggccg aacgagttcg gcagcgagta gacgccgagg tagccgccga
    19561 gcggccggcg gaactgttgc tccgggccga agaccagccg gcgcacggtc gagtgcatgc
    19621 cgtcggcacc gatcaccagg tcgaaccgct ccggcggcgc ctgctcgaag gtgacgtcca
    19681 caccgtcgcc gtcgtcgtgc agcgaagcga tggagtcccc gaaccggtag tccacgccgg
    19741 cccgcgtcgc gtcgtacagg atgctggtga gttcgccgcg caggatctcg acgtgctggt
    19801 cggagaggcc ggcgctgagc ttgtcgaggt cgacgtcgac cggtggtttg ccgtagcgct
    19861 ccatgctgag ccaccgggtt cgcgtgcggg cctcgtggat ccggtcggcc aggcccatcc
    19921 gggcggtgat ctcgacggcg gcggcgaaca ggtcgaccgc gtgaccgccg agaccgtggc
    19981 ggccggccga ggtgcgctcg accacggtgg gccggaagcc gtactgccgc agccagtagg
    20041 ccagcaccgg cccggcgacg ctcgcgccgg agatcagaac cttctgcatg acgccacctc
    20101 tcggttgttt acttaacgga aggtaagcaa tcgagaggtg aatctgtcaa tggttcactt
    20161 aacgggcggt cagctagtct tccggcatgc ccagagcacg cagcggcgac accaaggcgc
    20221 ggattcaggc ggtggcgctg gagctcttcg cgagcaaggg cctgcagcag accagcctgc
    20281 gggacatcgc tgaccagctg ggcatgacga agcctgcgct ctactaccac ttcgcgtcgc
    20341 gcgacgagct cgtgcgcagt ctcgcgatac cgctgatcga cgacatgacg gcgttcctcg
    20401 ccgggctgga ggcctcgccc gcggatccgc gggagctgct cggcgcgtac ttcgacgtca
    20461 cctaccggca ccgagtgctg ctgcaggtcg cgatccggga cctgagcgtg ctgcagcaga
    20521 tggacctcac cgaccacgtc ttcgactggc gccgccggat cgtcgcgctg ctgatcggcc
    20581 cgtcgccgtc cctggagcac caggtccggg gcatggtcgc gctcggcggc ctgtcggact
    20641 gcacggtcgc gttcgaggac gtcgacgtcg acgagctgcg caccgccgcg gtagccgcgg
    20701 cgtacgacgc cttgcggccg ggagttcagg gcatgtctgc ccagggcatg gcgccctagc
    20761 cgccggcgat tctcgagacc gcgaacagga cgatcaccag cacggtgaag acccggacgg
    20821 ctcgctggcc gttggtgacg accggccagg acaggaaccc gagccacgcc agcagcaggg
    20881 ccagcacgat cagcgccggg accgcgatcg ccaccggagt gaacactccg agcagagcca
    20941 gcgccagggt gatggccggc aaggtcagct tcggcatcgc gtgcagcttc gccacgaccg
    21001 ggtagctggc cttggtcacc cgctgccgaa gcggactcac cggctgactg ctggaagtac
    21061 tcatccgccc attgttccat ccctgtggac aactcccacg ccgctgcacc gggcgcggat
    21121 acattcctgt catgaccgca ctgccctccg tagccgccgt tcgcgccgac cttccggccg
    21181 tcctgacccg cttccgcacc ggcgacacgc acgccttcag cttcggcgac ggcgtgcccg
    21241 aagccgtgct gctcacctac gacgagttcg aggacctcgg cggcgagacc aagttcgccg
    21301 tcggcgacga ggtcctcgag cccgccgccc tcgccgccca gctccccgcc ctgctcacca
    21361 ccctccgggc cggctccgcg atccccgtcg tctggggcac agacggcgag cccgaagccg
    21421 tcctgctctc cacctccgcc taccgaaccc tccgcggcga cgacgaaccc ccagcaggcg
    21481 tccccgacga ccccacccaa cgcacctacc ccaccgagcc actgcccacg agccgcccgt
    21541 tcgacttgga cgagttcgcc gagggtgatc cgttcacgca ggagctgctc cgggagatcc
    21601 gggccgaccg gcagtcaccg gatgacaagc gctgagcggc agcggtacct gctggaggcg
    21661 agtccgcagt tcgccctgga cgtcaagctc ctgcaggcac gtgcgaaagc ggacccggcc
    21721 cggcacttgc acctgtaccg cgaggtcctg cggctgatcg aagacctgcg cgacggcgtg
    21781 agcgacgggc atcacgcgct cggctacgaa gccggaaagg gtgatctcag ggactgcgtg
    21841 accgcgtacg tcgcggccga cccgcaggcg aaggctaatc accggctggt gttccgggag
    21901 ctcggccctg cggcaccagg cgggcttccg cggcgggaac tgctggcggt gaaaccccgc
    21961 caggggaccg ggaacgtcta cgaacacgtc tgcgcccgcc tcggccggca cccggccgac
    22021 cgccagcctg gcttgaaccg cttcggcgac cgcgctccag gtgccaaggc gagtcaggcg
    22081 caacggcagg cggagctgga caccaagcgc gcgatcgcgc acgcgtgggc ggggcagatg
    22141 ccactggcct cctcacggcc actggcgcct cccgggacgg ggcagcgtgc cggtccgtcg
    22201 gtcccctcac cgtcgcgggc gcggaccgcg ggtgcgggac gtgctgcgag cgggcccggc
    22261 cggccgagcg gaacgggctg gccgcccccg agggaccgat gagccggagc cgcccgccgc
    22321 gtgggctgcg gatgcaggcg cttaaggtga cggagtgttc gtcgtgatca ggtttcgggt
    22381 gggggaagcg gtgcagcggg agttcgggcc gcggctggcg gctgctgtgg aggtgttgtc
    22441 gcggcagaag gggttcgtgg cggcgcggac cgggcggaac gtggacgacc cggaactgct
    22501 cgcgctgacc atggagtggg agaacgtcgg cagctaccgg cgggcgttgt
//
