LOCUS       NC_010628              21917 bp    DNA     circular CON 15-MAR-2024
DEFINITION  Nostoc punctiforme PCC 73102, complete sequence.
ACCESSION   NC_010628
VERSION     NC_010628.1
KEYWORDS    RefSeq.
SOURCE      Nostoc punctiforme PCC 73102 (Nostoc punctiforme ATCC 29133)
  ORGANISM  Nostoc punctiforme PCC 73102
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
            Nostoc.
REFERENCE   1  (bases 1 to 8234322)
  AUTHORS   Ekman,M., Picossi,S., Campbell,E.L., Meeks,J.C. and Flores,E.
  TITLE     A Nostoc punctiforme sugar transporter necessary to establish a
            Cyanobacterium-plant symbiosis
  JOURNAL   Plant Physiol 161 (4), 1984-1992 (2013)
   PUBMED   23463784
REFERENCE   2  (bases 1 to 8234322)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Pitluck,S., Chain,P., Malfatti,S., Shin,M., Vergez,L.,
            Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N., Kim,E.,
            Meeks,J.C., Elhai,J., Campbell,E.L., Thiel,T., Longmire,J., Potts,M.
            and Atlas,R.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2008) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000020025.1-RS_2024_03_15
            Annotation Date                   :: 03/15/2024 03:30:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,702
            CDSs (total)                      :: 7,602
            Genes (coding)                    :: 7,314
            CDSs (with protein)               :: 7,314
            Genes (RNA)                       :: 100
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 288
            CDSs (without protein)            :: 288
            Pseudo Genes (ambiguous residues) :: 0 of 288
            Pseudo Genes (frameshifted)       :: 133 of 288
            Pseudo Genes (incomplete)         :: 166 of 288
            Pseudo Genes (internal stop)      :: 86 of 288
            Pseudo Genes (multiple problems)  :: 85 of 288
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:28:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7714880
            Orig. end                         :: 7736797
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP001037.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 2351359
            Source DNA available from John C. Meeks (jcMeeks@ucdavis.edu)
            Bacteria available from ATCC: ATCC 29133
            Contacts: John C. Meeks (jcMeeks@ucdavis.edu)
            David Bruce (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LLNL
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            NOTE: This genome has an insertion element which pops out under
            certain growth conditions. When it pops out, gene Npun_R0414 is put
            together in one piece.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21917
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="20"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21917
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21917
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11917](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11917)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    134..152
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.0"
                     /tool="antismash"
     gene            complement(235..1404)
                     /locus_tag="NPUN_RS31685"
                     /old_locus_tag="Npun_R6237"
     CDS             complement(235..1404)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0004024 - alcohol dehydrogenase activity,
                     zinc-dependent [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011321167.1"
                     /locus_tag="NPUN_RS31685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6237"
                     /product="zinc-dependent alcohol dehydrogenase"
                     /protein_id="WP_012412461.1"
                     /sec_met_domain="ADH_N (E-value: 5.7e-30, bitscore: 102.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 6.5e-16, bitscore:
                     57.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVCWNGANDVRVQSVPDPTILNPRDAIIKITSTAICGSDLHIY
                     GGYIPTVQQGDIIGHEFMGEVVEVGRGVNNLKIGDRVVVPSTIGCGNCHYCQHDMWSLC
                     DNSNPKGWIEEKLFGNITSAIYGYSHMLGGYAGAQAEYIRVPFADVGVVKVPPDLPDEM
                     LLFISDAIPTGYMGAELCDIQPGDTVAVWGCGAVGQFAMISAYMMGAEKVIAIDRFPER
                     LEMAKKFAKAEVINYEEVNAGEALKEMTGGRGPDACIDAVGLEAHGVGLEDFYDQTKQK
                     LRLETDRPHVLREMMVACRKGGTLSIMGVYGGFVDKIPFGAAFNKGLTFRMGQMHGQKY
                     MHLLLQMILDGKLDPSFVVTHQLPLEQAPHAYHIFQQKKDNCIKVVLKP"
     gene            complement(1505..2203)
                     /locus_tag="NPUN_RS31690"
                     /old_locus_tag="Npun_R6238"
     CDS             complement(1505..2203)
                     /NRPS_PKS="Domain: Polyketide_cyc (84-210). E-value:
                     3.9e-26. Score: 83.8. Matches aSDomain:
                     nrpspksdomains_NPUN_RS31690_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017654586.1"
                     /locus_tag="NPUN_RS31690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6238"
                     /product="SRPBCC family protein"
                     /protein_id="WP_012412462.1"
                     /transl_table=11
                     /translation="MTSTSGDKLSTSQTEASEVERWASLIGGGAMVLMGLRQGSLRGAL
                     TALAGGGLIYQGATKQSTIQQAQEAIGINQPIKVEKTVTINKPADELYRYWHNFENLPT
                     FMKHLKSVNVYNEKRSHWIANAPLGNSVEWDADILEDRENEFISWASVEGADVDNSGFV
                     RFKKAPGDRGTEVKVVLEYNPPGGALAATVAKLFGEEPEQQIGDELRRFKMLMEAGEIA
                     TTEGQPSGRS"
     aSDomain        complement(1574..1951)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NPUN_RS31690_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="3.90E-26"
                     /label="NPUN_RS31690_Polyketide_cyc.1"
                     /locus_tag="NPUN_RS31690"
                     /protein_end="210"
                     /protein_start="84"
                     /score="83.8"
                     /tool="antismash"
                     /translation="INKPADELYRYWHNFENLPTFMKHLKSVNVYNEKRSHWIANAPLG
                     NSVEWDADILEDRENEFISWASVEGADVDNSGFVRFKKAPGDRGTEVKVVLEYNPPGGA
                     LAATVAKLFGEEPEQQIGDELR"
     gene            complement(2309..3406)
                     /locus_tag="NPUN_RS31695"
                     /old_locus_tag="Npun_R6239"
     CDS             complement(2309..3406)
                     /GO_function="GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011321165.1"
                     /locus_tag="NPUN_RS31695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6239"
                     /product="DJ-1/PfpI/YhbO family deglycase/protease"
                     /protein_id="WP_012412463.1"
                     /transl_table=11
                     /translation="MTDHNNHSGKKKVAILIEQAVEDAEFTVPYNGLKQAGIEVVVLGS
                     RMNEKYKGKRGKLSIQADGTTTEAIAAQFDAVIIPGGMAPDRMRRNINTVRFVQEAIQQ
                     GKLVAAVCHGPQVLIEGNLLKGKQATGFIAIAKDMINAGAKYLDEPVVVDGNLITSREP
                     GDLPIFTTAILSRLGYGGKDAALPNEKDTSAEWWKLADAWGGSTKGDITRGLNNALAGE
                     RYSLEAFEKYLEKESDREVNSVFQEIIANKQRHIQKLETYIHHLGEKPSLGANIANQYA
                     KVKTAFTGSDDIYQLRSALGDVQTGIGDIGNLSAMFTDPVATAIFKEIYHDLLKYEQRL
                     VELYRARIGTQIQPPKPTTGAAVSM"
     gene            complement(3513..3914)
                     /locus_tag="NPUN_RS31700"
                     /old_locus_tag="Npun_R6240"
     CDS             complement(3513..3914)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010995066.1"
                     /locus_tag="NPUN_RS31700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6240"
                     /product="DUF2267 domain-containing protein"
                     /protein_id="WP_012412464.1"
                     /transl_table=11
                     /translation="MEYNEFITHVQSLAQSDSREEAEGATRATLETLKERIAGDEAEEL
                     AKNLPPQLGNYLRGREGDSGQSFNLQEFIARASQKENIEPTTAVIHVRAVFAVLQNAIS
                     PEQFATLHAYFSHDYEELFAISSTGELTA"
     misc_feature    4237..4248
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.34"
                     /tool="antismash"
     gene            4277..4675
                     /locus_tag="NPUN_RS31705"
                     /old_locus_tag="Npun_F6241"
     CDS             4277..4675
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006195096.1"
                     /locus_tag="NPUN_RS31705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6241"
                     /product="DUF6335 family protein"
                     /protein_id="WP_012412465.1"
                     /transl_table=11
                     /translation="MAEKNHNDEIQTNDLPQEITESYGTGVKELPGYNIGGRSIREERR
                     EYTETSPELTGGDVDAYWQDADAVGDEAVGGTTATPDKNVTEELEAAVGLEMADSEFLH
                     TNDILEDRDSDRWELDPKSSEDYQERGE"
     gene            5187..5678
                     /locus_tag="NPUN_RS31710"
                     /old_locus_tag="Npun_F6242"
     CDS             5187..5678
                     /GO_component="GO:0030089 - phycobilisome [Evidence IEA]"
                     /GO_function="GO:0031404 - chloride ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016037 - light absorption [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017320717.1"
                     /locus_tag="NPUN_RS31710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6242"
                     /product="orange carotenoid protein N-terminal
                     domain-containing protein"
                     /protein_id="WP_012412466.1"
                     /transl_table=11
                     /translation="MTYTQTSDPTIREHVQAWQKLDVDQQLALFWFIYKEMGGSITPAA
                     PGASTVSPEIAEGLFNQVKELSHEQQLQVQRDLINKVDTQISREYGSLGDTTKLLFWYR
                     LSQGMDNGTIIPVPSDYQLPSESKALFGRIQGLGFEQQITLFRDYVSPMGTGAKAGAEI
                     "
     misc_feature    complement(6178..6194)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
     gene            6573..7022
                     /locus_tag="NPUN_RS31715"
                     /old_locus_tag="Npun_F6243"
     CDS             6573..7022
                     /GO_component="GO:0030089 - phycobilisome [Evidence IEA]"
                     /GO_function="GO:0031404 - chloride ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016037 - light absorption [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015207912.1"
                     /locus_tag="NPUN_RS31715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6243"
                     /product="orange carotenoid protein N-terminal
                     domain-containing protein"
                     /protein_id="WP_012412467.1"
                     /transl_table=11
                     /translation="MTSTNINFLEQSVSKFQSLDTDDRLTVLALLYTEIGDEIPSLCLN
                     NVPNEKTANLVAQIQNLPQAEQLFALRQLLNQDEVGETAIPTEEYAAMNADDKLGFWYQ
                     LAQNLGTSIINVPDDYIPSEKATEVVDLLHTPNIEDLVTFFKRVL"
     gene            complement(7191..9671)
                     /locus_tag="NPUN_RS44320"
                     /old_locus_tag="Npun_R6244"
     CDS             complement(7191..9671)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012411659.1"
                     /locus_tag="NPUN_RS44320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6244"
                     /product="FG-GAP repeat protein"
                     /protein_id="WP_012412468.1"
                     /transl_table=11
                     /translation="MANSLFNLSDLNGSNGFVINGFGGESGYRVSNAGDINNDGIDDLI
                     IGAPYTSPNGNDRAGRSYVVFGGTNVGSSGIFNLSDLNGSNGFLMNGIAEFDFSGRSVS
                     NAGDINNDAVDDLIIGAPFAFRNGIGQAGESYVVFGGTNVASSGTLNLSDLDGTNGFTI
                     TGIGQIDTIGWSVSNAGDINNDGVDDLIIGGYGKSYVVLGKKNVGSGGTFNLSDLNGNN
                     GFTITAIGDFDSFLVSNAGDINNDGIDDLIIGKYEADSNGNENAGQSYVVFGGKNVGSG
                     GIFNVFSLNGTNGFAINGIAAGNESGFSVSNGGDINGDGIDDLIIGAFRAPANGVIQAG
                     QTYVLFGGMNVGNSGTFNLSDLNGTNGFAINGITENSFSSSSVSNAGDVNADGIDDLII
                     GAPDGEQTYVVFGGKNVGNSGSLNLSDLNGTNGFTIPGGDAIGLSVSYAGDINNDGVDD
                     LIIGAPFASPNGIISAGQSYVLFGGPNIGVGTLNLTGTPGADTLIGTSGNNIIDGKACN
                     DTLTGNGGQDKFVIRPSDGNDIITDFGGVGKGTNPSAQVIANVDTLQFTGSGLTARNLL
                     LTQNGKNLEVTFENVANTKVTLQNFQLENLDNLKASGARPAIGNILFDRQTSITDSFDV
                     FDANSTQTSLFNKNTVTFLNDLSNNITGFDNSADVVNGQGGNDKIDGKSGNDLLRGGAG
                     NDTLIGGTGNDTLVGGAGADRFLYNTNAPFTSAAVGQDAIADFKHSQGDKIILDKTTFS
                     AITSAAGTGFSNTSDFKITSSAATSTAKIVYDAVSGQLFYNQNGSAAGFGNGGLFATLN
                     GAPTLIGSDFIIQA"
     gene            complement(10001..11917)
                     /gene="shc"
                     /locus_tag="NPUN_RS31725"
                     /old_locus_tag="Npun_R6245"
     CDS             complement(10001..11917)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015207917.1"
                     /locus_tag="NPUN_RS31725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6245"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_012412469.1"
                     /sec_met_domain="T2TS (E-value: 3.9e-132, bitscore: 440.2,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTQDRVKVNQVAEAIAASQQYLLSIQNPAGYWWAELESNVTITA
                     ETVLLHKIWGTDQTRPLHKVEAYLRQEQRQHGGWELFYGDGGELSTSVEAYMALRLLGV
                     PATDPAMIRAQAFILQRGGISKTRIFTKLHLALIGCYNWRGIPSLPPWIMLLPKAFPVN
                     IYEMSSWARSSTVPLLVVCDRKPVFITDPTINLDELYAEGIDRVRWELPQSGDWTDLFL
                     TLDQGFKWAESLNLVPFREEGIKAAEKWILERQEATGDWGGIIPAMLNSMLALRCLDYD
                     RSDPIVERGLQAIDNFAIETDNSYRVQPCVSPVWDTAWVMRALVESGFVPDHPAVVKAG
                     EWLLQKQILDYGDWAVKNRQGKPGAWAFEFENRFYPDVDDSAVVVMALHLAKLPNEKIK
                     QAAIARAVNWIASMQCKPGGWAAFDLDNDQDWLNSIPYGDLKAMIDPNTADVTARVVEM
                     LGACDLSIDSDNLERSLTYLLREQETEGCWFGRWGVNYIYGTSGVLSALALIDPQRHKL
                     SIERGAAWLLGCQNLDGGWGETCRSYDDPSLKGKGDSTASQTAWALIGLLAAGEATGKL
                     AVKAIEQGIGYLMATQQPDGTWFEANFTGTGFPCYFYLKYHLYQQYFPLIALGRYQAAI
                     KES"
     gene            12037..13266
                     /locus_tag="NPUN_RS31730"
                     /old_locus_tag="Npun_F6246"
     CDS             12037..13266
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011321335.1"
                     /locus_tag="NPUN_RS31730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6246"
                     /product="glycosyltransferase"
                     /protein_id="WP_012412470.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-18,
                     bitscore: 66.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVIVLGLTLLSLAIWLGLLCFWGQFWRTDQQLEVETLYKTSLQS
                     LPVVCAVVPARNEAELIPTSLRSLLLLDYPGSFNVFLVDDRSTDRTANFAEGVAHAVGK
                     PQQLHIISGESLPAGWSGKLWAVEQGIKSASKFAPDYFLLTDADIEHDPGNLRRLVAKA
                     VQEDLDLVSVMVRLRCESFWEKLLIPAFVFFFQKLYPFRWVNNPNNPTAAAAGGSILIA
                     REALERIGGIQVIRQALIDDCALAQAVKKNGGQGDKETRGINKIPSQGRIWLGLSSLTH
                     SLRPYDSLATIWDMVARTAYTQLNYSPLLLLGTLVGMPLIYLVSPVCVILGIVWGNWAI
                     ALTGLLGWLLMTFAYYPTIRFYKCSPWFALSLPAIAFLYTLMTLDSALRHWQGRGGAWK
                     GRVYPSSDNL"
     gene            13345..13581
                     /locus_tag="NPUN_RS31735"
     CDS             13345..13581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017746150.1"
                     /locus_tag="NPUN_RS31735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_041565757.1"
                     /transl_table=11
                     /translation="MTTATTTNNPVTVPKKLPFLESICWQTADVYRFTSEQMLSRYERG
                     WQYHNLFNNLEGEELNFVQELARRYKSWLQVCL"
     gene            13578..14357
                     /locus_tag="NPUN_RS31740"
                     /old_locus_tag="Npun_F6247"
     CDS             13578..14357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017746149.1"
                     /locus_tag="NPUN_RS31740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6247"
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
                     /protein_id="WP_012412471.1"
                     /transl_table=11
                     /translation="MTFRLEHHNQILTVLESLDSDILRKGSAYFGGGTLLAFEFEEYRW
                     SKDIDFIASVGTEGYKYLRTVVFEGGHEALFRDLSKIQVGRSTTDQYGIRMIVFVDDMP
                     IKTEIIAETRFQLDPPRYPKWSLVPCLSFNDCFTSKLLSNSDRYADDSVEARDLIDLAI
                     LRLQSRIPQASIEKAEKAYQVMRPLKRAIELFQGRPDYREKCFLSLQVDQAQIPKILDG
                     IDLLSTDLGLSHTPRAFQEQHDILADLETQIKKQEDS"
     gene            complement(14429..14779)
                     /locus_tag="NPUN_RS31745"
                     /old_locus_tag="Npun_R6248"
     CDS             complement(14429..14779)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015207931.1"
                     /locus_tag="NPUN_RS31745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_R6248"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_012412472.1"
                     /transl_table=11
                     /translation="MRFLYHPDRKNISLPGVLYALGDPVRLEIVRLLATEGEQCCAQFD
                     FAIAKSTMSNHFKILRESGIVFTRKEGTHHINILRREDLEVLFPGLLDAVLKAAQPLPV
                     SPASDKQTASRV"
     gene            14860..15183
                     /gene="trxA"
                     /locus_tag="NPUN_RS31750"
                     /old_locus_tag="Npun_F6249"
     CDS             14860..15183
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0015036 - disulfide oxidoreductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="trxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017314800.1"
                     /locus_tag="NPUN_RS31750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6249"
                     /product="thioredoxin"
                     /protein_id="WP_012412473.1"
                     /transl_table=11
                     /translation="MSSITNVTEATFKQEVLESEIPVLVDFWAPWCGPCRMVGPVVDEV
                     AAEYEGQVKFVKLNTDQNPTVASHYGIRSIPTLMVFKGGRQVDTVVGAVPKTTLNKTLA
                     QHL"
     gene            15348..16142
                     /locus_tag="NPUN_RS31755"
                     /old_locus_tag="Npun_F6250"
     CDS             15348..16142
                     /NRPS_PKS="Domain: PKS_KR (9-124). E-value: 5.4e-08. Score:
                     24.9. Matches aSDomain:
                     nrpspksdomains_NPUN_RS31755_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012412474.1"
                     /locus_tag="NPUN_RS31755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6250"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_012412474.1"
                     /transl_table=11
                     /translation="MDLKLHGKSALVSGSTAGIGLAIAQALAQEGASVIVNGRSEERVT
                     QAIAKIQQSTPEAKVSGVVADTSTASGVEELFQKVPHVDILINNLGIYEPKTFFDITDE
                     DWLNIFQVNVLSGVRLSRQYLQKQLEQNWGRIIFISSESAIQIPVEMIHYGTTKTAQLA
                     IARGLAEMTIGTGVTVNSVLPGPTRSEGVEEFITNLAQERGINRAEVEAEFFQNVRPSS
                     LIKRFATNEEVAAIVVYLSSPVASATNGAALRVDGGVIRSIV"
     aSDomain        15375..15719
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NPUN_RS31755_PKS_KR.1"
                     /evalue="5.40E-08"
                     /label="NPUN_RS31755_PKS_KR.1"
                     /locus_tag="NPUN_RS31755"
                     /protein_end="124"
                     /protein_start="9"
                     /score="24.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="ALVSGSTAGIGLAIAQALAQEGASVIVNGRSEERVTQAIAKIQQS
                     TPEAKVSGVVADTSTASGVEELFQKVPHVDILINNLGIYEPKTFFDITDEDWLNIFQVN
                     VLSGVRLSRQY"
     CDS_motif       15378..15467
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NPUN_RS31755_0001"
                     /evalue="4.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="NPUN_RS31755"
                     /protein_end="40"
                     /protein_start="10"
                     /score="16.3"
                     /tool="antismash"
                     /translation="LVSGSTAGIGLAIAQALAQEGASVIVNGRS"
     misc_feature    complement(16237..16252)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
     gene            16267..17379
                     /locus_tag="NPUN_RS31760"
                     /old_locus_tag="Npun_F6251"
     CDS             16267..17379
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015130166.1"
                     /locus_tag="NPUN_RS31760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6251"
                     /product="alkene reductase"
                     /protein_id="WP_012412475.1"
                     /transl_table=11
                     /translation="MTTEINLFSSYQLGNLELPNRIVMAPLTRNRASKGNVPYELNATY
                     YAQRASAGLIISEATQVTPEGQGYPATPGIHSPEQVEGWKLITDAVHQQGGRIFLQLWH
                     VGRISHPDLQPNGALPVAPSAIAPKGEAATYEGPKPFVTPRALETSEIPQIVEQYRQGA
                     ANALAAGFDGVEIHSANGYLIDQFLRDRTNQRTDKYGGSIENRTRFLLEVTEAVTSVWD
                     SNRVGVRLSPSGTFNDIGDSNPLETFGYAAQALNQFNLAYLHIYEATEADIRHGGIIVP
                     TSHIRDRFTGTLIVNGGYTREKGDAVLANKAADLVAFGTLFISNPDLPRRLALNAPLNE
                     ANQATFYGGGEQGYTDYPFWSAANEAVAKA"
     gene            17601..18266
                     /locus_tag="NPUN_RS31765"
                     /old_locus_tag="Npun_F6252"
     CDS             17601..18266
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159: dihydropteridine reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011321420.1"
                     /locus_tag="NPUN_RS31765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6252"
                     /product="nitroreductase family protein"
                     /protein_id="WP_012412476.1"
                     /sec_met_domain="PF00881 (E-value: 7.5e-31, bitscore:
                     106.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSITQTIPLDVPSAIAQRRSIKTFKADPIAPELLKQLVELTVAA
                     PSSYNIQDWQIILVQDEAQKAALSAASWNQQQIVQAPVTFVFAADPNAGEQNLAAILER
                     ASETGAWNEGTVNYFKTAIPQFQAGLGDKRREYAIKDAIIAATHLVLAAESLGLSTCFM
                     NGWIEDRVKQVIGAGDNPDLAIAVLVPVGYAAEPRLNPGRLPFSSNVSVDRIGNPYAG"
     gene            complement(18364..18546)
                     /locus_tag="NPUN_RS42270"
     CDS             complement(18364..18546)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NPUN_RS42270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_167315686.1"
                     /transl_table=11
                     /translation="MMSREWWQIIVETAIHSVSCLNRTVLGVVEQKSISIIYRVGINGT
                     REWVFNSHSRVLELR"
     gene            18545..19843
                     /locus_tag="NPUN_RS31770"
                     /old_locus_tag="Npun_F6253"
     CDS             18545..19843
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015130168.1"
                     /locus_tag="NPUN_RS31770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6253"
                     /product="MFS transporter"
                     /protein_id="WP_012412477.1"
                     /transl_table=11
                     /translation="MSLASFLARRSFHYGWLVAGLTFLALLVAAGIRSAPGVFIVPLEQ
                     EFGWSRATISLAISINLVLYGLIGPFAATVMERIGIRQMMVFSLAVIALGVGLTTLMSA
                     SWQLVLLWGVVVGSGSGVIALVLGAIVVNRWFFEKRGLVLGILTASTATGQLVFLPMLA
                     SVADRFGWRTAALALTGAALLIIPAIAAFMRDRPADVGLRPFGDNSETVEISQPRANSI
                     SSTLNALWLGMRKRDFWLLFGSFFICGASTNGLIGTHLIPACIDHGIPEVKAAGLLAIM
                     GLFDFFGTTMSGWLSDRWNNRYLLCWYYGLRGLSLIFLPFSFNFSFYGLSIFAVFYGLD
                     WIATVPPTVRLVANAFGKENVGVMFGWIVAGHQLGAATAAFGAGVLRTWTGSYLQAFIL
                     SGILCLIAAVGVLQIGQTPTKGDSQLSSVTLNS"
     gene            19918..20607
                     /locus_tag="NPUN_RS31775"
                     /old_locus_tag="Npun_F6254"
     CDS             19918..20607
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015130169.1"
                     /locus_tag="NPUN_RS31775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6254"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_012412478.1"
                     /transl_table=11
                     /translation="MATTALIVGAGSGLSASLARLFAKEGFTVALAARQIEKLTQLTRE
                     IDAVSFAADVSKPNEVEQLFIDIDRKIGSPNVVIYNPSFRVRGPLIDLDPGEVAKTLDV
                     TAYGGFLVAQAATKRFLQLGGGAIFFTGASASVKGYPLSAPFAMGKFALRGLAQSIARE
                     LAPKNIHVAHFVIDGAIRSAVRQDPVDNPDSTLDPDAIAQTYLSILRQPRSAWTYEVEL
                     RPWVENF"
     gene            20642..21409
                     /locus_tag="NPUN_RS31780"
                     /old_locus_tag="Npun_F6255"
     CDS             20642..21409
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017743930.1"
                     /locus_tag="NPUN_RS31780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Npun_F6255"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_012412479.1"
                     /transl_table=11
                     /translation="MKIDFGATAVDYAKHRAGFPSSLFNKLSEYGIGLPGQNIVDLGTG
                     TGTLARGFADRGAYVIGIDPSASLLEQARQLSESTQIKVDYRVATAENTELPDASADVI
                     TAGQCWHWFDRPRAVQEVTRILRKNGSIAIAHFDWIPLKGNVVEATEQLIKAHNPAWNL
                     DGGNGMYPLWLQDIGEGGFREIRTFSYDVFVSYTHEAWRGRIRASAGVGASLTPEKVEV
                     FDQELATLLEAKYPTPILQVHHRVWAAIAKSPL"
     misc_feature    complement(21881..21897)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.82"
                     /tool="antismash"
ORIGIN
        1 tttgcccatc ggggattcct ttgtaataag taccctctgg agttttaaca tcagcttgtg
       61 ctacattaat gtcactaaaa gcctgaccta gtaagaacat aaatcctacc aggaaaacta
      121 caataatctg agaaatgcga atattccgca accatgaaat tacttgattc ataaaaaacc
      181 tcaattgcat tatgttaggt gtacaattca aaacgctgaa tgactattca ccattcaggg
      241 tttaagaaca actttgatgc agttgtcctt tttttgttga aaaatgtggt aggcgtgggg
      301 tgcttgttct agaggtaatt gatgggtgac aacgaaggat ggatcgagtt ttccatccaa
      361 aatcatctgc aataacaaat gcatatattt ttgtccatgc atttgtccca tcctaaaagt
      421 tagacccttg ttgaaggcag caccaaatgg gattttgtct acaaaaccac cataaacacc
      481 catgattgaa agagtcccgc ctttacgaca ggcaaccatc atttcccgca gaacgtgggg
      541 acggtcggtt tccaatctga gcttttgttt tgtctggtcg tagaagtctt ctaaaccaac
      601 gccgtgtgct tctaaaccaa cagcatcgat gcaagcatcg gggccacgac caccagtcat
      661 ctctttcaac gcttcgccag cattaacttc ttcgtagtta atcacttctg ctttggcaaa
      721 ctttttcgcc atttccaggc gttcgggaaa gcgatcgatt gcgatcactt tttcggctcc
      781 catcatgtag gcgctaatca tggcaaactg tccaacagca ccgcaacccc aaaccgctac
      841 agtatcaccc ggttggatat cgcataactc tgcacccata taaccggtgg gaatagcatc
      901 ggagatgaat aacaacatct catccggtaa gtctggcgga actttgacga cacctacatc
      961 agcaaagggt acacggatat attctgcttg tgcgcctgca taaccaccta acatgtggga
     1021 gtacccataa atggctgagg tgatattgcc aaataatttt tcttcaatcc aacctttagg
     1081 attggaatta tcacacaatg accacatatc atgttggcaa taatggcaat taccacagcc
     1141 aatggtagaa ggaacaacta cgcgatcgcc tatttttaaa ttgttgactc ctctgccaac
     1201 ttccacgact tctcccataa attcgtgacc gataatatca ccctgttgca ctgtggggat
     1261 atagccgcca taaatatgta gatcggagcc acaaatcgcc gtggaagtaa ttttaataat
     1321 tgcatcacgc gggttgagaa ttgtcgggtc tggtaccgac tgtacccgga catcattagc
     1381 gccgttccag cagactgctt tcatagttat tagtccttag tcagtagtca ttggtcatta
     1441 gtaattcatc attggtcatt cgctttaggc aaaggaataa tgacaataga caaagaacaa
     1501 ataactaact tcgtccagaa ggctgacctt cggtggtggc aatttcgcct gcttccatta
     1561 gcattttgaa gcggcgcaat tcatcaccaa tttgctgttc tggttcttca ccaaaaagtt
     1621 tagctacggt agctgccaat gctccaccgg gggggttata ctccaaaaca accttgactt
     1681 ccgtgccgcg atcgcctggt gcttttttga agcgaacaaa accagaatta tcaacgtctg
     1741 caccttccac agaagcccaa gaaataaact cattttcccg gtcttcgaga atatctgcat
     1801 cccattctac actgttaccc aagggtgcat tggcaatcca gtgagaacgc ttttcattgt
     1861 acacattgac agatttgaga tgcttcataa atgtgggcag attttcaaag ttgtgccaat
     1921 aacgataaag ttcatctgct ggtttgttga tcgttactgt cttttcaact ttgatgggtt
     1981 ggttgatacc aattgcttct tgtgcttgct ggattgtgct ttgcttggtt gcaccttgat
     2041 aaatcaaacc gccacctgct aaagctgtca gcgctccccg caatgaacct tgccttaaac
     2101 ccatcagcac catagcacca ccaccaatca gagatgccca acgctctact tcactagctt
     2161 cagtctggct ggtacttaat ttatcgcctg atgttgaagt cactttttat atctccatca
     2221 cagtaattac catagaggcg caaatatcct cttgtttcta tctctgtgtt atttgcgcct
     2281 ctgcgatagc cgtctaagtt caaaaaactt acattgacac tgccgcgcct gtagtcggct
     2341 taggaggctg aatctgagta cctatccgcg cccgatacag ttctactaat cgctgttcgt
     2401 atttcaataa atcgtggtaa atttctttga aaatagcagt tgctactggg tcagtgaaca
     2461 tcgcagacaa attcccaata tcgccgatac cagtttgcac atcacctaaa gcagaacgta
     2521 actgatatat gtcatcactt cctgtaaagg cagtttttac tttggcatac tgattagcaa
     2581 tatttgctcc taaagagggt ttttcaccca aatgatgaat ataggtttct agcttttgaa
     2641 tatgccgctg tttatttgca attatttctt gaaagactga gttgacttcc ctatctgatt
     2701 ctttttccaa gtatttctca aatgcttcta gcgaataacg ctcaccagca agggcattat
     2761 ttaaacctct ggtgatatca cctttagttg agccacccca agcatcagct agcttccacc
     2821 attcagcact tgtgtctttc tcatttggta atgcagcatc tttgccacca taacccaaac
     2881 ggctcaaaat agctgtggta aaaattggca agtccccagg ttcacgagat gtaatcaaat
     2941 ttccgtcaac taccactggc tcatctagat attttgcgcc agcgttaatc atgtccttgg
     3001 caatagcaat aaaaccagtg gcttgtttac ctttgagcaa gttgccttca atcaaaactt
     3061 gtggcccgtg gcaaaccgca gcaactagtt ttccttgttg tatagcttct tggacaaagc
     3121 gtactgtgtt gatgttgcgc cgcattctgt cgggagccat cccaccagga attatcacag
     3181 cgtcgaattg ggctgcgatc gcttctgttg tagtaccatc agcttgaatg ctaagtttgc
     3241 cgcgtttacc cttatatttt tcattcattc tggaaccaag gactactacc tctattccag
     3301 cttgttttag tccattataa ggaactgtaa attctgcatc ctctactgcc tgttcaatga
     3361 ggatagcaac ttttttcttc ccagaatgat tgttatggtc agtcataaat gttattgcct
     3421 gtttatttct agtatttaac tagtaagaat attcatcaat taggaaagtt aaaaatcctg
     3481 aattgtgaac ttgatttttt ttgaattgcc tattatgcag ttaattcacc tgttgatgaa
     3541 atagcaaata gttcttcata atcgtgagag aaataggcgt gaagtgtagc aaattgttcg
     3601 gggctaatag cattttgcaa tacagcaaat acagctcgca catgaattac agcagtcgtt
     3661 ggttcaatgt tttctttttg gcttgcacga gcgataaatt cctgcaagtt aaaggattga
     3721 ccactatctc cttctctgcc tcgtaaataa ttgcctagtt gtggaggcaa atttttagct
     3781 agttcttctg cttcatcacc tgctatccgt tcttttagag tttctagcgt ggcacgggta
     3841 gcaccttctg cttcttcacg agaatctgat tgagcaaggc tttgtacatg tgtaatgaac
     3901 tcgttgtatt ccactgtcta cctccgcttc ccaaaatttt tgaatgtttt gctatttgac
     3961 atttaggtag ttaaaagcat tagtctaaaa ttaaagtgga gcagtttttt atttttccta
     4021 ttattaataa aaatagttac gagcgaaaat tttgctactg aataatttcg gctttacaag
     4081 ttttcactca taactaaaaa cttcaactac aagttgcttg accatgattt catatttcca
     4141 atggtatggt gcgatcgcta gtttagcttc gtactaaggg gatagattct tttatttcta
     4201 aagctataca tctctagtaa gataacttag tgataggaaa acgttattgt gagaatgcag
     4261 aaaaaaggct agtatcatgg cagaaaaaaa tcataatgac gaaattcaaa ccaatgattt
     4321 gccacaggaa attaccgaat cctatggtac tggtgtgaaa gagttgccag gatacaatat
     4381 tggtgggcgc tcaattagag aagaaagacg tgagtataca gaaactagtc ctgaactcac
     4441 tggtggagat gttgatgctt attggcaaga tgcagatgca gttggggatg aagctgttgg
     4501 tggtactact gcaactcccg ataaaaatgt aactgaggag ctagaagcgg cagtggggct
     4561 agaaatggct gactctgagt ttctccatac caatgatatt ttagaggatc gtgatagcga
     4621 tcgctgggag ttagatccga agtcttctga agattatcaa gagcggggag aataagctca
     4681 ataaaacaga agccgtattt ctactgtgaa ttcacaaatt taatgtggct aaataggcag
     4741 tgcttttcta agcactgtca caacaaaagg aatcatctat ctatcgaaat atatctcgaa
     4801 aatctctgaa tttggcagcg ttgaaattgc caatttttta atctgccttt cccaagcatt
     4861 attctagctt ttgatatagc aatccgcttt gatttctgtt cgcgcaacgt ggtgtagcaa
     4921 taattatttg tgtagcaggc aaaaggcaag aagcctattt gagttatact gaatgttttc
     4981 agaaatcaaa tatgagtttt atattgcatt cgtatctaag tttaatgatt atttctaaag
     5041 tgagactata ctttacccaa tttatgttct gcttataatt attcttcttt ctgattttaa
     5101 tacctatgtc ttcagtaggg taaaacgtta aatctgcatt tgataacatt actaagtgta
     5161 ctgataactt acaatcggag ttaataatga catacacaca aactagcgat ccaactattc
     5221 gcgaacatgt tcaagcttgg caaaagttgg atgtggatca acaactggct ttattttggt
     5281 tcatttataa agaaatgggt ggctcaatta caccagctgc tcctggggcc agtactgttt
     5341 ctccagaaat cgcggaaggt ttgtttaatc aagttaagga attatctcac gaacaacaat
     5401 tacaagttca gcgtgacttg attaataaag tagataccca gatttctcgt gaatatggtt
     5461 ctttgggtga tactactaag ctactgtttt ggtatcgatt atctcaaggt atggacaatg
     5521 gtactatcat tcctgtaccg tctgactatc aactaccctc agaatctaaa gcgttgtttg
     5581 gtagaattca aggattaggt tttgagcaac agattactct tttccgtgat tatgtgtcgc
     5641 caatgggtac tggagcaaaa gcaggtgctg aaatttagca ctttttaact ttttaggctg
     5701 cttgaggtta tctatttagt ctctaaatga agataagatg gtcttgtttg cgaagtgctg
     5761 tagacacatc tatctatacc tctcttctta aagtttttta tatccgtcgg tcgcttaata
     5821 taaatttgaa ttttgatgac tggcggtttc atttttcttg agaaataaac acagagtaaa
     5881 aataacactt ttaccctgtg agcatttatt tcatgaggtc acttgcaccc tacagtccta
     5941 acgccctttg ttttgtaatc aatatattaa aagtaattat atttgaatta atctgccttt
     6001 tggttggttt aaatatgctt tttttatatt aagctctatc tttttatagt tttctatcta
     6061 aaattaaatt cttaaaattg atagagatat taaaatggat aattcaattt tttacatcgg
     6121 agatttaatg agttttttca tatcttatac caaattacat ctatgataaa cacaaaaatg
     6181 taactaattt accattagct attatggttg acaaagatat tgattaatga aagccatagg
     6241 tttcacattt taaaggttta aatagaggcg attgctaaac aatcttcaga gctatttaat
     6301 acttaagtta tgatacaaca ccgactaata taatagatac attgctagca aaagtccagc
     6361 gattttaagt aataagagtg gtgggacata cctaaaattg cagctatttg cttgacggaa
     6421 atttctattg aaagaagaga cttaccaaaa ttaaataatc ttccctagtt ctgttgatta
     6481 gtaaacccct agtcaaactg gttccaagca aaattataat tttcacttaa gaattttgag
     6541 ttaattaagt agttaattac tttgaggtgc ttatgacttc tacaaacatc aattttttag
     6601 aacaaagtgt atcaaaattt cagagtttgg atacagacga tcgcttgact gtcctagcct
     6661 tactttatac tgaaattggt gatgaaattc cgtctctatg tctcaataat gtaccgaatg
     6721 aaaagactgc gaatttagtt gcacaaattc aaaacctgcc acaggcagaa cagctttttg
     6781 ctttgcgtca gttgctaaac caagatgaag taggagaaac agcaattcct actgaagagt
     6841 acgctgcaat gaacgctgat gataaattag gtttttggta tcaattagcc caaaatttgg
     6901 gaacttcaat catcaatgta ccagatgact atataccttc tgaaaaagct acagaagtag
     6961 tagatttact tcacacacca aacattgaag atttagtgac tttcttcaag cgggtgctgt
     7021 aacagttttg agttaagaaa caaaggtggg tctatacccc acctttgttt ttaagttaat
     7081 gattatggta tcttctcctg aacattagtt aaggaaattt atctgttaag gcagcaggga
     7141 gagagaaaaa ggcttaaccc aagcgtattg gtatgtgcct tattaattaa ctacgcttga
     7201 atgatgaagt ctgaacctat caaagtcggc gcaccattca gagtcgcaaa tagaccacca
     7261 ttgccaaaac cagccgcgct accattttgg ttatagaaca actgtccact cacagcgtca
     7321 tacacaattt tcgccgtgct ggtcgctgct gaagaagtaa ttttaaaatc actggtatta
     7381 ctaaaacccg ttcccgcagc agaagtaata gcactaaagg tagtcttatc caggataatt
     7441 ttgtcacctt gggagtgttt aaaatcagcg atcgcatctt gaccaacagc agcactggta
     7501 aagggagcat tcgtgttgta caaaaatctg tcagcacccg caccacctac aagggtatca
     7561 ttgcctgtac caccaatgag agtatcatta ccagcgccac cccgcagcag gtcgttgcca
     7621 ctcttgccgt cgattttgtc attacctccc tgaccattga ccacatcagc agagttatca
     7681 aaacccgtaa tgttgttgga taggtcattg aggaatgtca ccgtgttctt gttgaacagg
     7741 ctagtttgag tggaattggc atcaaaaaca tcaaaactgt cggtgatgct agtttgccta
     7801 tcaaacagga tattgccaat cgctggtctt gctccagaag ctttcagatt atccaagttt
     7861 tctaactgaa agttttgcag agtgactttg gtattagcca cattttcaaa ggtaacttct
     7921 agattcttac cattttgagt caatagcaga tttcgggcag ttaagccact acctgtaaat
     7981 tgcagtgtgt caacattggc aattacctgt gctgatgggt ttgtgccttt accaacacca
     8041 ccaaaatcag tgatgatgtc attgccatcg cttgggcgaa ttacaaactt atcttgaccg
     8101 ccattacctg ttagggtatc gttacaagct ttgccgtcga taatattgtt gccagatgtg
     8161 cctataagag tatctgcacc aggagttcct gtcaggttaa gagtgccgac cccgatattt
     8221 ggccccccaa acaacacata gctttgccca gcgctaatga tgccgttggg tgaggcaaaa
     8281 ggtgcgccta taatcaggtc gtcaacgcca tcgttgttga tgtcgcctgc ataactaact
     8341 gaaagaccta tcgcgtcacc cccaggaatg gtgaaaccat tagtgccatt caagtcagag
     8401 aggttgaggc taccactatt gcctacattc ttccccccaa acaccacata ggtttgctca
     8461 ccatcaggtg cgcctataat caggtcatca ataccatcag cgttaacgtc tcccgcattg
     8521 ctgactgaag agcttgagaa gctattctca gtaataccgt taatggcaaa gccattagtg
     8581 ccattcaagt cagagaggtt gaaagtgcca ctattgccga cattcatccc tccaaacagc
     8641 acataggttt gccctgcttg aatgacaccg ttggcggggg cacgaaatgc cccaataatc
     8701 agatcgtcaa tgccatcacc gttaatgtcc cccccattgc tgactgagaa gcctgattcg
     8761 ttacccgcag caatgccgtt aatggcaaag ccattagtgc cgtttaagga aaagacattg
     8821 aagatgccgc cactgccgac atttttccct ccaaaaacca catagctttg cccagcattc
     8881 tcgttgccgt tggagtcggc ttcatatttc ccaataatca ggtcgtcaat gccatcattg
     8941 ttgatgtctc ccgcattgct gaccaaaaag ctgtcaaagt caccaatggc agtaattgta
     9001 aagccattat tgccattcaa gtcagagagg ttgaaagtgc cgccactgcc cacattcttc
     9061 ttccccaata ccacatagct ttttccatat cccccaataa ttaagtcgtc aacaccatcg
     9121 ttgttgatgt cccccgcatt gctgaccgac caacctatgg tgtcaatttg accaataccg
     9181 gtaattgtga agccattagt accatccaaa tcagagaggt tgagggtgcc gctactggca
     9241 acattcgtcc ctccaaacac cacatagctt tccccagctt gaccaatgcc gttacgaaag
     9301 gcaaaaggtg ccccaataat caagtcgtca acggcatcgt tgttgatgtc tcccgcattg
     9361 ctgactgacc tgcctgagaa gtcaaattca gcaatcccgt tcattaaaaa gccattactg
     9421 ccatttaagt cagagaggtt gaagatgccg ctactgccga catttgtccc tccaaatacc
     9481 acatagcttc gcccagcacg atcgttaccg ttgggggagg tgtaaggtgc ccctataatc
     9541 aggtcgtcaa tgccatcgtt gttgatgtcc cccgcattgc tgaccctgta gcctgattcg
     9601 ccaccaaagc cgtttataac aaagccattg ctgccattca agtcagagag attaaataat
     9661 gagttagcca tgattttttc ctatggtcag ggagtaagct tcaaaggcct aaattagaaa
     9721 tttcgtgttt taaactgaag tattgttatg gagtgccaag tagaatttgt gctacgctaa
     9781 ccatctacta gctacatttc tggttgttag tttatattgc ttttccaact gtcacaatcg
     9841 attatttttt aactttaaga aaaacacaca tactatttat acaaaaaata ttttttatga
     9901 tgcacaaata tgccaaataa tgcgctttta atatggaatt tcttaataaa gtaatacagt
     9961 aggggcgaac aattttatgc ccctactaca gcaacgaata ttaactttct ttaatcgctg
    10021 cttgatagcg acctagtgca attaaaggaa agtattgttg atacagatga tatttaagat
    10081 agaaatagca agggaagcca gtccctgtaa agtttgcctc aaaccaagta ccatcaggct
    10141 gttgagttgc cattaaatag ccaattcctt gctcaatagc cttaacagct aatttaccag
    10201 ttgcttcacc tgctgccaag aggccaatta aagcccaagc agtttgagat gcagtactat
    10261 ctccttttcc tttgagactg gggtcatcat agctgcggca agtctcaccc caacccccat
    10321 ctaggttttg gcatcccagt aaccaagctg ctccccgttc tatactgagt ttgtgccttt
    10381 gaggatcaat taatgccaag gctgacaaaa cgccactggt gccgtagata taatttacac
    10441 cccaacgacc aaaccaacag ccttcggttt cttgttcgcg taaaagataa gttagcgatc
    10501 gctctaaatt atcactatca attgacaaat cacaagcacc aagcatttct acgactctag
    10561 ccgtaacatc tgcggtattt ggatcgatca tggctttcaa gtcgccataa gggatggagt
    10621 taagccaatc ttgatcgttg tccaaatcaa aagcagccca cccaccaggt ttacattgca
    10681 tagatgcaat ccagtttacc gcccgtgcga tcgcagcctg cttgattttt tcattgggaa
    10741 gtttcgccaa atgtaaagcc atcaccacca ccgccgagtc gtctacatcg ggataaaacc
    10801 gattttcaaa ctcaaaagcc caagcccctg gttttccttg gcgatttttt acagcccaat
    10861 ctccataatc taaaatttgt ttttgcaaca accattctcc agcctttacc acggcgggat
    10921 gatctggtac aaagcctgat tctactaagg cacgcatcac ccaagctgta tcccaaaccg
    10981 gtgaaacaca gggctgaacc cggtagctat tatctgtttc aatggcaaag ttatcaattg
    11041 cttgcaaacc tcgttccaca atcgggtcgc tgcggtcata atccagacag cgcaaagcta
    11101 gcattgaatt cagcatcgcc ggaataatgc cgccccagtc gcctgtcgct tcttgccgtt
    11161 ctaaaatcca tttttcggcg gctttgatac cttcttcacg gaaggggact aaatttaggc
    11221 tttctgccca tttgaatcct tggtcgaggg tgaggaataa atcagtccaa tcgccacttt
    11281 ggggtaattc ccaccggact cgatcgatac cttcagcgta tagctcatct aggttgatag
    11341 ttgggtcagt gataaaaaca ggtttgcgat cgcatacaac cagtaatggt actgtactgg
    11401 aacgtgccca gctagacatt tcgtagatat taactggaaa agcttttggc aataacatta
    11461 tccaaggcgg tagcgaggga ataccgcgcc agttgtagca gccaatcaag gctaagtgca
    11521 acttggtaaa aatccgagtt ttgctgatac caccccgttg gagaataaaa gcttgcgccc
    11581 gaatcatcgc cggatcggtt gctggtacac ctagcagtct cagcgccatg taagcttcaa
    11641 ctgaagtgct aagttctccg ccatcaccgt agaaaagttc ccagccgcca tgctgtcgtt
    11701 gctcttgacg cagatatgct tcaactttgt gtaaaggtct ggtttggtct gttccccaaa
    11761 tcttatgcaa aaggactgtt tcagcagtaa tcgtgacatt agattctaac tctgcccacc
    11821 agtagcctgc tggattttga atcgaaagta aatattgttg gctggctgcg atcgcttctg
    11881 caacttgatt gacttttacc ctgtcttgtg tttgcatcaa atactatcta acctcacact
    11941 caacactagc tatgaatacg gcaatactat gaaaaatttt ttctttattg gtagacatag
    12001 tattgtgtct gagtcactga gaatttgcaa taggtcatgg gtgtaattgt attaggattg
    12061 acgctgttat cattggcaat ttggttagga ttactgtgtt tttggggaca attttggcgg
    12121 acagaccagc aattagaggt agagacgttg tataaaacgt ctctacaatc attacctgtg
    12181 gtttgtgccg tggttccagc gcgtaacgaa gctgagttaa taccaaccag cttgcgatcg
    12241 ctcctactcc tagattatcc tggttctttt aacgtatttt tggtagacga tcgcagtaca
    12301 gatcggacag caaattttgc cgaaggggtt gcacacgctg taggtaaacc ccagcaattg
    12361 catattatct ctggcgaatc actgcctgct ggttggtcgg gcaaactttg ggctgttgag
    12421 caaggtataa aaagtgctag taaattcgca cccgactatt ttttactgac cgatgcagat
    12481 atcgaacacg atcctggtaa tctccgccga ctcgttgcga aggctgttca agaagattta
    12541 gacttggttt cggtaatggt gcgactcaga tgtgagagct tttgggaaaa acttttgatt
    12601 ccggctttcg tgtttttctt ccaaaaactc tatccctttc gttgggttaa taatccaaac
    12661 aatcccacag ccgccgcagc tggaggttct attctgatcg cccgtgaagc tttagaacga
    12721 attggaggca ttcaagtgat tcgccaagct ttaatcgacg attgcgccct agctcaagct
    12781 gttaagaaga atgggggaca aggggacaag gagacaaggg gaataaacaa aattcctagt
    12841 caagggcgta tctggttagg attgagtagc ttgactcaca gtctacgtcc ttatgactcg
    12901 ctagcgacaa tttgggatat ggttgctcgt actgcctata ctcaactaaa ttattcgcca
    12961 ttactactct tgggcacttt ggtgggaatg cctttgattt atctagtttc acctgtgtgt
    13021 gtaattctag gtatagtttg gggcaattgg gcgatcgcac ttacgggttt attaggatgg
    13081 ctattgatga ctttcgctta ctacccgaca atccgctttt ataaatgttc tccgtggttc
    13141 gcgttgagct tgcctgcgat cgcgtttctc tatacgctga tgactttaga ctcagcatta
    13201 cgtcattggc aagggcgcgg cggcgcttgg aaaggaagag tttaccccag ttcggataat
    13261 ttatagttag aataaaatta aatttcgata tcgatagtgc taatctaaat aaaagtaagc
    13321 tgaaagtggt tgattaaaag agctatgaca accgcaacaa caacaaataa tcctgttact
    13381 gtccccaaaa agctgccttt tctggagtca atttgttggc agactgccga tgtgtatcgg
    13441 tttacttcag aacaaatgct gagtcgctat gagcgtggct ggcagtatca taatctattt
    13501 aataatcttg aaggtgaaga actcaatttt gttcaggaac tcgctagacg ctataagtcc
    13561 tggttgcaag tttgtttatg accttcaggt tagaacacca taatcaaatt ctcacagttc
    13621 ttgaatcttt agattcggac atacttagga agggttctgc ttactttggt ggcggaaccc
    13681 ttcttgcatt tgagtttgaa gaatatcgct ggagtaagga tattgatttt attgcttctg
    13741 ttggtacaga aggctataaa tatttacgta cagtggtatt tgaaggtggg catgaagcat
    13801 tgtttcgtga tttaagcaaa atccaagttg gacgtagcac aactgaccaa tatggaattc
    13861 ggatgatcgt ttttgtggat gatatgccga ttaaaacgga aattatcgct gaaactcgtt
    13921 ttcagctaga cccaccaaga tatccaaagt ggtcactcgt cccttgctta agcttcaatg
    13981 actgttttac ctctaagctg ctgtcaaatt ctgatcgtta cgcggatgac agtgttgaag
    14041 caagagattt gatcgatcta gcaattctta ggctgcaatc tcgaatccct caagcatcaa
    14101 ttgagaaggc tgaaaaagct tatcaggtta tgcgcccttt gaaaagagcg attgaactct
    14161 ttcagggaag acctgattac agggagaaat gctttctcag tctacaagtt gatcaagctc
    14221 agatacccaa aattctcgat ggtattgatt tactctcaac agatttaggt ttatctcaca
    14281 ctccaagggc ttttcaagaa caacatgata tcttggctga tttagaaaca caaattaaaa
    14341 aacaagaaga ttcttaaaac agatcgcgtt atccaatgcc caatgcccca ttccccattc
    14401 cccatttccc attacccatt ccccattcct aaacccttga agctgtttgt ttatcactcg
    14461 caggactaac aggcaatggt tgagccgctt tcaataccgc atccagcaac cctggaaata
    14521 gcacctctaa atcttcacgc cgtagtatgt tgatgtgatg tgtcccttct ttacgtgtaa
    14581 agactatccc agactcccgc aaaatcttaa aatgattgga cattgtagac tttgcgatcg
    14641 caaaatcgaa ctgggcacag cattgttccc cctcagtggc cagcagtcgc acaatctcta
    14701 gccgcactgg atcgcccaat gcatacagca ctcccggtaa agaaatattt tttctatctg
    14761 gatgataaag aaatctcata gttgcattat ctcatcgagt ggcatatatt tttattattc
    14821 gatattatcg aataatagaa ttaattagga aggcaattta tgtcatccat tacaaatgtc
    14881 acagaagcca cattcaagca agaagtcttg gaaagtgaaa ttccggtctt agtagacttt
    14941 tgggccccgt ggtgcggccc ttgccggatg gtaggcccag tagtcgatga agttgctgcg
    15001 gaatacgaag gacaggtgaa atttgtgaag ctgaacacag atcagaatcc tactgtcgcc
    15061 agccattatg gaattcgcag cattccgacg ctgatggttt ttaagggagg tcggcaggtt
    15121 gatactgtcg taggggcagt cccaaaaacc accttgaata agaccttagc acagcatctt
    15181 taatctaggt actgttgtga gaagcattta gtttctagtc ttctctaatc aagggaggca
    15241 ggagtcagaa tacacctgac ttctgtacag acgcgattaa tcgcgtctct ccccactcct
    15301 gacttctgac tcctgaattc tgtttcaact aatggggaaa gagcgaaatg gacttgaaat
    15361 tgcatggtaa atccgcgcta gtgagcggct caaccgcagg tattggttta gcgatcgccc
    15421 aagcgctagc tcaagaaggt gcatcagtaa ttgtcaatgg tcggtctgaa gaaagagtaa
    15481 cccaagcgat cgctaaaatt caacaaagta cacctgaagc gaaagtttct ggcgttgttg
    15541 ctgacacaag tactgcatca ggggtagagg aactctttca aaaagttcct cacgttgata
    15601 tcctcattaa taatctgggt atttatgagc caaaaacctt ttttgatatt accgatgaag
    15661 attggttaaa catatttcag gttaacgttc tcagtggagt ccgtttgagt cggcaatatc
    15721 tgcaaaagca gctagagcaa aactggggac ggataatttt tatctccagc gaatctgcga
    15781 ttcaaattcc ggtggaaatg attcactatg gcacaactaa gacagcgcaa ctagccattg
    15841 cacgaggtct agcagaaatg actatcggga ctggagtcac tgtaaactcc gtcctccccg
    15901 ggccaacccg ttcagaagga gttgaagagt ttatcaccaa cctggcgcag gaacgtggta
    15961 tcaatcgtgc tgaagtcgag gctgagtttt ttcaaaatgt gcgtccaagt tccttaatca
    16021 aacgctttgc aactaatgaa gaagtagctg cgatcgtagt ttacctttct agtcctgtag
    16081 cttcagcaac taatggtgca gctttgcggg tagatggtgg cgttattcgg tcaattgttt
    16141 agtatttgaa ccacatttcg taggcgtaca gtcaacttaa cgttataaag ggcggttaga
    16201 aagcgcgtct acactaaact ttacccacct gcgtgggtta aaaaactttg aattggagta
    16261 aacaacatga ctactgagat caatttattc tcttcttacc aattagggaa tttggaactc
    16321 cctaaccgaa ttgtgatggc acccttaacc cgaaaccgag ccagtaaggg aaacgtgcca
    16381 tacgaactga atgctaccta ctacgctcaa cgtgcttccg ccggattgat tatttctgaa
    16441 gcaacacagg taactcctga aggacaaggt tatcccgcta caccaggaat tcattcacca
    16501 gaacaggtgg aaggatggaa gttaataact gatgccgtac atcagcaggg tggaagaatt
    16561 tttctgcaac tatggcatgt aggcagaatt tcccatcctg acttacaacc aaatggagct
    16621 ttacctgtgg caccttctgc cattgctcct aaaggtgaag ctgcaactta tgaggggcca
    16681 aaaccctttg ttactccccg cgctttagaa acttcagaaa taccgcaaat agtagaacag
    16741 tatcgtcagg gagctgcaaa tgctctagcg gctgggtttg atggggtaga aattcactca
    16801 gctaatggtt atttaataga tcaatttctc cgcgatcgca ccaatcaacg tacagataaa
    16861 tatggaggtt ccattgagaa tcgcacccga ttcttgttgg aagtgacaga ggcggtaact
    16921 agtgtgtggg attctaaccg agttggggtt cgtttgtctc ccagtgggac ttttaatgat
    16981 ataggtgact ccaatcccct agagacattc ggttatgcgg ctcaagcgtt gaaccagttt
    17041 aatttggcat atctgcatat ttatgaggca accgaggcag atatcagaca tggcgggata
    17101 attgtaccca ccagtcatat ccgcgatcgc tttacaggta cactcatcgt caatggtggt
    17161 tatacccgtg aaaaaggtga tgcagtgctg gcaaacaaag cagcagattt agttgccttt
    17221 ggcacattat ttatatcaaa cccagattta ccccgacgct tggctttaaa tgcaccacta
    17281 aatgaagcaa atcaagcaac cttttatggt ggcggtgaac aaggatatac agactatcca
    17341 ttttggtcgg ctgctaatga ggcggtagct aaggcgtaat tcgtaattat gacttcatga
    17401 ctgtaccttg cgcgtgccgt aggcaaatcg tttgttctga aacaagaaat aatttttatt
    17461 tttgtttcgg gaataaatag atttgcttgt atcctaatta cgttagcgcc acgcaaagcg
    17521 agtctgcgtt agcttttagc gtctcgtaga gaacgtaatt acgaattatt tggtcataac
    17581 tcaactatca ggagaatctc atgagttcca tcacccaaac cataccttta gatgtaccca
    17641 gtgcgatcgc tcaacgtcgt tcaatcaaaa cttttaaagc agaccccatt gccccagaac
    17701 tgctcaagca actggtagag ttaaccgtgg cagcgcccag tagttataat atccaggact
    17761 ggcaaattat tctcgtgcaa gatgaggcgc aaaaggcagc attatcagca gcatcgtgga
    17821 atcaacagca aattgttcaa gcacctgtaa ccttcgtttt tgccgccgat cctaacgcag
    17881 gcgaacaaaa cttggccgcg attttggagc gtgcaagtga aactggagca tggaatgaag
    17941 gcacggtaaa ctattttaaa accgccatcc cacaatttca agctgggtta ggcgacaaac
    18001 gacgcgaata tgcaatcaaa gatgccataa ttgctgctac tcatttggtg ttagcagcag
    18061 aaagtttggg attatccact tgttttatga acggttggat tgaggatagg gtaaaacaag
    18121 tgattggtgc tggggataat ccagatttag cgatcgctgt tttagttccc gttggctatg
    18181 cagccgaacc acgcttaaat ccaggtcgtt taccattctc ttctaacgtc tctgtggata
    18241 gaatcggtaa tccttatgca gggtagcttt ccttaaattg ggcataaagg aagaggtaaa
    18301 agagtcgagt tctgagcctc attaatggag ttcaaaagct cattgacgag gctttgaggt
    18361 tcatcaacga agctctagga ctcgtgaatg actattaaag acccattcac gagtcccatt
    18421 tatacctact cgataaatta tagatattga tttctgctcc accactccca ataccgttcg
    18481 gttaagacaa gagacgctat gaatcgccgt ctctacaata atctgccacc actccctact
    18541 catcatgtcc ctagcctcct tcctagcgcg tcgttcgttc cactatggtt ggctcgttgc
    18601 aggtttaaca ttcctcgcct tactcgttgc agccggaatt cgctctgctc ccggagtttt
    18661 tatagtgcct ctcgaacagg agtttggctg gagtagagca actatatctt tagcaatctc
    18721 tattaactta gtactttatg gactgattgg cccttttgcc gccacagtta tggagcgaat
    18781 cggcattcgc caaatgatgg tgttttcact tgctgtcatt gctctcggtg tcggtttaac
    18841 tactttgatg tcagcatctt ggcagctagt tttgctgtgg ggtgtagttg tcggttctgg
    18901 tagcggagtt atcgccctgg ttttgggcgc tattgttgtc aatcgctggt tttttgagaa
    18961 gcggggttta gttctcggca tcctaaccgc cagtacagcc acggggcaac tggtattttt
    19021 gcctatgctg gcctcagtag ccgatcgctt tgggtggcga actgcggctt tggctctgac
    19081 tggtgcagca cttttaatta ttccagcgat cgcagccttt atgcgcgatc gtccggcaga
    19141 tgttggtttg cgaccctttg gcgacaacag cgagactgta gaaatatcac agcctagagc
    19201 aaattccatc agctctaccc tcaacgccct ctggctggga atgcgtaagc gcgatttttg
    19261 gctgttattt ggtagctttt ttatctgtgg cgccagcaca aatgggttaa ttggaactca
    19321 tctgattccc gcttgtattg atcacggtat tcctgaagtc aaagctgcgg gtcttttggc
    19381 aatcatgggg ctattcgatt tttttggaac tactatgtct ggttggctct ctgacagatg
    19441 gaataatcgc tacttattgt gctggtacta cgggctgcgg ggtttgtctt tgattttctt
    19501 gcccttcagt ttcaactttt ctttctatgg actttctatt ttcgccgtct tctatggact
    19561 tgattggatt gctaccgtac caccgacagt ccgtcttgtt gccaatgcct ttggtaaaga
    19621 aaatgtcggc gtgatgttcg gttggattgt cgcaggacac cagcttggtg cagccacagc
    19681 agctttcgga gccggagtgt taagaacttg gacgggtagc tatttacaag cgtttatttt
    19741 atcaggtatt ctctgtctga ttgccgcagt tggtgtattg caaattggtc aaactcccac
    19801 taaaggcgat tcacaactat cttcagtcac gctcaattct taatctatga attttttaat
    19861 cgaatggcat taagaaaagc tctaagctag gcagaataag cactacaggt ttaaaatatg
    19921 gcaacaacag ctttaattgt cggcgcaggt agtggactga gtgcatcttt agcccgccta
    19981 tttgccaaag aaggattcac cgtagcttta gcggctcgtc aaattgaaaa acttactcaa
    20041 ttgactagag aaattgacgc agttagtttc gctgctgatg tctcaaagcc aaatgaagta
    20101 gaacaattat ttattgatat tgatcgtaaa attggttccc ccaatgttgt tatttacaat
    20161 cccagttttc gggtgcgggg gcctcttatt gatttagacc ctggtgaggt ggcaaaaacc
    20221 ttagatgtaa ctgcttatgg tggctttctc gtggcccaag ctgctaccaa aaggtttttg
    20281 caacttggcg gtggtgctat attttttacg ggagcctcag cgagtgttaa aggttatcct
    20341 ctgtctgctc cctttgcaat gggtaaattt gcactgcgcg gtttggctca gagtattgct
    20401 agagaattag caccaaagaa tattcatgtg gcgcatttcg tgattgatgg ggcaatccgt
    20461 tcagcagttc gccaagatcc agtagataat cctgatagta ctcttgaccc agatgcgatc
    20521 gctcaaactt atctcagtat tctccgccag ccccgcagtg cttggactta tgaagtagaa
    20581 ctacgtcctt gggtagagaa cttctagcct agacaattgt tacaaaaatg gttttgcagg
    20641 tatgaaaatt gattttggtg caactgctgt tgattacgca aaacaccgcg ctggctttcc
    20701 cagttcatta tttaataaac tgtctgaata tggtataggt ttaccaggac agaatattgt
    20761 tgaccttggt acagggacag gaacactagc gcggggcttt gctgatagag gtgcttatgt
    20821 aattggcata gatccatcag catcactttt agaacaagcg agacagttaa gcgaatcaac
    20881 ccaaatcaaa gtagattatc gagtcgcaac tgcagaaaat accgagttac cagatgcaag
    20941 tgctgatgta atcactgctg gacaatgttg gcattggttt gatcgtcccc gtgctgtcca
    21001 ggaagttact cggatattga gaaaaaatgg ctcaattgcg atcgctcatt ttgattggat
    21061 acccttaaaa ggtaatgtag ttgaagcaac agaacaactg atcaaggctc ataatcccgc
    21121 gtggaatttg gacggtggga atggaatgta tcccttgtgg ttacaagaca ttggcgaagg
    21181 aggattccga gaaattcgca cattttctta cgatgtattt gtgtcttata cacacgaagc
    21241 ttggcggggg cgaattcggg caagtgctgg tgtgggagcc agcttgacac cagaaaaggt
    21301 agaagtattt gaccaagagt tggcgacatt actcgaagca aaatatccca cgccaatcct
    21361 tcaggttcac cacagagttt gggctgcgat cgccaaatca ccgctatgaa aaaatataat
    21421 tgaagctcta tgttccatcc agagaaagcc atgaccagcg acagatagcc agtcgccagt
    21481 catgacttat aatacaaaac tagttgccct tgataggttt gattctagcg atcgcttgta
    21541 gtaacatttt tggcagccaa aaaagataac aatatagttg ttttgcctga ctataaagcg
    21601 aaaataactt tgcttcactt agtaaagtat atggtcgtac tgctctgaga agttctgcaa
    21661 atttatcttc agtcgcagtt tcaactgaac cactgacaaa ataaccttgt aaatgtggag
    21721 gtaatgccca gttaatatta ggatctggct gatgtattac aggctcaaca tttccccgcc
    21781 atgcaactcc cataatttgc atagtttgat acaccattgt gttccatcct ttgtctctga
    21841 agtaatccaa gccttgtcct acatcaggag aagccaaatc atgaaataaa attaaagcat
    21901 ctgcttctgc aaattgt
//
