LOCUS       NC_010612              10807 bp    DNA     circular CON 17-DEC-2024
DEFINITION  Mycobacterium marinum M, complete sequence.
ACCESSION   NC_010612
VERSION     NC_010612.1
KEYWORDS    RefSeq.
SOURCE      Mycobacterium marinum M
  ORGANISM  Mycobacterium marinum M
            Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
            Mycobacteriaceae; Mycobacterium; Mycobacterium ulcerans group.
REFERENCE   1  (bases 1 to 6636827)
  AUTHORS   Stinear,T.P., Seemann,T., Harrison,P.F., Jenkin,G.A., Davies,J.K.,
            Johnson,P.D., Abdellah,Z., Arrowsmith,C., Chillingworth,T.,
            Churcher,C., Clarke,K., Cronin,A., Davis,P., Goodhead,I.,
            Holroyd,N., Jagels,K., Lord,A., Moule,S., Mungall,K.,
            Norbertczak,H., Quail,M.A., Rabbinowitsch,E., Walker,D., White,B.,
            Whitehead,S., Small,P.L., Brosch,R., Ramakrishnan,L.,
            Fischbach,M.A., Parkhill,J. and Cole,S.T.
  TITLE     Insights from the complete genome sequence of Mycobacterium marinum
            on the evolution of Mycobacterium tuberculosis
  JOURNAL   Genome Res 18 (5), 729-741 (2008)
   PUBMED   18403782
REFERENCE   2  (bases 1 to 6636827)
  AUTHORS   Stinear,T.P., Seemann,T., Harrison,P.F., Jenkin,G.A., Pidot,S.J.,
            Davies,J.K., Small,P.L.C., Johnson,P.D.R., Brosch,R., Cole,S.T.,
            Ramakrishnan,L. and Parkhill,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-AUG-2007) Pathogen Sequencing Unit, Wellcome Trust
            Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
            CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000018345.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 14:09:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,598
            CDSs (total)                      :: 5,546
            Genes (coding)                    :: 5,407
            CDSs (with protein)               :: 5,407
            Genes (RNA)                       :: 52
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 53 of 139
            Pseudo Genes (incomplete)         :: 113 of 139
            Pseudo Genes (internal stop)      :: 14 of 139
            Pseudo Genes (multiple problems)  :: 34 of 139
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:27
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5944062
            Orig. end                         :: 5954869
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000854.1.
            DNA and bacteria are available from Dr Lalita Ramakrishnan,
            lalitar@u.washington.edu.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10807
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="31"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10807
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10807
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5807](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5807
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(546..559)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.05"
                     /tool="antismash"
     misc_feature    complement(1011..1026)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.5"
                     /tool="antismash"
     gene            1611..2261
                     /locus_tag="MMAR_RS24530"
                     /old_locus_tag="MMAR_4889"
     CDS             1611..2261
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011738749.1"
                     /locus_tag="MMAR_RS24530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4889"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_012396419.1"
                     /transl_table=11
                     /translation="MSRHWPLFDLRITTSRLQLRLPTEELCDQLIDTILDGVHEPDRMP
                     FSVPWTRAPQGELPYNTLSFLWRELAGFSRDDWALPLAVVVEGRAVGVQGLRASNFPIA
                     GEVESGSWLGLRYQGNGLGTEMREAALHFVFCELGAQAATSAAFADNPASIAISRRQGY
                     RENGVDRVAREGAAAQRVRFRLTRDDWLRQRHVEVRVEGFDRCRELFGVSRAA"
     gene            complement(2280..2627)
                     /locus_tag="MMAR_RS24535"
                     /old_locus_tag="MMAR_4890"
     CDS             complement(2280..2627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_215316.1"
                     /locus_tag="MMAR_RS24535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4890"
                     /product="VOC family protein"
                     /protein_id="WP_012396420.1"
                     /transl_table=11
                     /translation="MTLSVEMVTFDCSDPARLAGWWAEHFGGTAHELLPGEFIAVTRPA
                     GPRLGFQKVPDPTPGKNRVHLDFSAADVDGEVSRLAAAGATEVQRHQFGENFRWVVMAD
                     PEGNVFCVVGQ"
     gene            complement(2652..3944)
                     /locus_tag="MMAR_RS24540"
                     /old_locus_tag="MMAR_4891"
     CDS             complement(2652..3944)
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012396421.1"
                     /locus_tag="MMAR_RS24540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4891"
                     /product="M18 family aminopeptidase"
                     /protein_id="WP_012396421.1"
                     /transl_table=11
                     /translation="MSDAPTTSATARGLGEFIDASPSPFHLCATVARRLLDAGYTELSE
                     IDRWPQQPGRYFTVRAGSLVAWDSGGVGTAQAPFRIVGAHSDSPNLRVKQHPDRLVAGW
                     QVVALEPYGGAWLNSWLDRDLGVSGRLSVRAPGVRGGISHRLVRIDEPILRVPQLAIHL
                     AEDRKSLTLDPQRHVNAVWGVGAQRGSFLGYVAQRAGLAEGDVLAADLMTHDLTPAAVI
                     GANADLLSAPRLDNQASCYAGLEALLAAESDQVLPVLAIFDHEEVGSTSDHGAQSNLLN
                     TVLERIVLAGGGVREDLLRLLPASLLASADMAHATHPNYPERHEPSHQIAVNAGPVLKV
                     HPNLRYATEGRTAAAFALACQQAGVNLQRYEHRADLPCGSTIGPMTSARTGIPTVDVGA
                     AQLAMHSARELMGAADVAAYSAALRAFYAPE"
     gene            3955..5004
                     /locus_tag="MMAR_RS24545"
                     /old_locus_tag="MMAR_4892"
     CDS             3955..5004
                     /EC_number="1.11.1.-"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012396422.1"
                     /locus_tag="MMAR_RS24545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4892"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_085979926.1"
                     /transl_table=11
                     /translation="MAVGDCGIHARVGRVPSVQPQPILAPLTPAAIFLVATIDAGGEQT
                     VHDALTEISGLVRAIGFRDPTKHLSVVASIGSDAWDRLFSGPKPAELHPFVPLTGPRHN
                     APATPGDLLLHIRAETMDVCFELAGRILKAMAPAVTVVDEVHGFRFFDNRDLLGFVDGT
                     ENPGGAIAIGATTVGDEDPDFAGSCYVHVQKYVHDMGSWDSLSVTEQERVIGRTKLEDI
                     ELDESTKPANSHIALNVITDEDGVELKIVRHNMPFGEVGKGEYGTYFIGYSRTPVVTER
                     LLRNMFLGDPPGNTDRVLDFSTATTGGLFFSPTIDFLDDPPPLPPAPAAVPTTDDGSLS
                     IGSLKGISE"
     gene            5001..5807
                     /locus_tag="MMAR_RS24550"
                     /old_locus_tag="MMAR_4893"
     CDS             5001..5807
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011738747.1"
                     /locus_tag="MMAR_RS24550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4893"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_012396423.1"
                     /sec_met_domain="Linocin_M18 (E-value: 3.3e-93, bitscore:
                     309.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLYRDLAPVTEAAWAEIELEATRTFKRHIAGRRVVDVSDPGGP
                     VTAAVSTGRLIDVKAPTDGVIAHLRASKPLVRLRVPFTLSRNEIDDVERGSQDSDWDPV
                     KAAAKQLAFVEDRTIFEGYGAASIEGIRSSSSNPPLTLPEDPREIPDVITQALSELRLA
                     GVDGPYSVLLAADVYTKVSETTEHGYPIREHLNRLVDGDIIWAPAIDGAFVLTTRGGDF
                     DLQLGTDVAIGYTSHDADTVQLYLQETLTFLCYTAEASVALSPHSG"
     misc_feature    6298..6313
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     gene            6365..7849
                     /locus_tag="MMAR_RS24555"
                     /old_locus_tag="MMAR_4894"
     CDS             6365..7849
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020730752.1"
                     /locus_tag="MMAR_RS24555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4894"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_012396424.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-42, bitscore:
                     144.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEDERARIPAGEPDLSFDVIVLGAGPVGENAADRCQAAGLHVAV
                     IERDLVGGECSYWACVPSKALLRPVVAVADARRVDGAREAISDSISAAAVFDRRDRYVS
                     NWDDGDQADWVSGIGATLIRGHGRLAGPRRVSVSDHDGQTLMIAARHAVVVCTGSRPTL
                     PDLPGITEAWPWTNRQATEASSVPRRLAIVGAGGVGVEMATAWQGLGSSVILLARSRLL
                     SRMEPFVGDFVGRGLTRSGVDVRVGISVRALHRPHPDAPVTLELDDDTRLEVDEVLFAT
                     GRAPRTDDIGLQTVGLAPGNWLDVDDTCRVNAVDGGWLYAAGDVNHRALLTHQGKYQAR
                     IAGSAIGARAAGDSLDTAPWGAHATTADHHAVPQAFFTDPEAAAVGLTAEQAARAGHRI
                     KTIDVDIGDVVTGAKLFADGYAGRARMVVDVDRGCLLGVTIVGPGAAELLHAATIAIAG
                     QVPIDRLWHAVPCFPTISELWLRLLEAYRDSFFVLV"
     misc_feature    complement(6406..6419)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            7875..8339
                     /locus_tag="MMAR_RS24560"
                     /old_locus_tag="MMAR_4895"
     CDS             7875..8339
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020785833.1"
                     /locus_tag="MMAR_RS24560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4895"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_012396425.1"
                     /transl_table=11
                     /translation="MATSDGFHPDFPAETAAPDRRRAQVHHIKASEISSDTAQSEGLRR
                     FAALSGRSVGAEKIWMGETHVLPRTVSANHHHGDSETAIYVRSGRPEFVFHDGEQEVRI
                     ATEPGDYIFVPPYLPHREENPDPTMPAEVVIARSTQEAIVVNLPGLYPLS"
     gene            8440..8904
                     /locus_tag="MMAR_RS24565"
                     /old_locus_tag="MMAR_4896"
     CDS             8440..8904
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020730751.1"
                     /locus_tag="MMAR_RS24565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4896"
                     /product="YbjN domain-containing protein"
                     /protein_id="WP_012396426.1"
                     /transl_table=11
                     /translation="MTEPLCATLIERYLCTRGRRYFRGQHDGEFFFVTDAHPQRLHVHL
                     EISPAHPEVFAIRVAPACFFPAGDRALLARFADRWNTQRRGVTAIVHNSSDPQRIGVTA
                     YKSQWIAGPVDFSEFAVFVDRAIGASIELFGELNRVAELPQTPPLMRDAG"
     gene            complement(8916..9590)
                     /gene="purQ"
                     /locus_tag="MMAR_RS24570"
                     /old_locus_tag="MMAR_4897"
     CDS             complement(8916..9590)
                     /EC_number="3.5.1.2"
                     /EC_number="6.3.5.3"
                     /GO_function="GO:0004642 -
                     phosphoribosylformylglycinamidine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010908773.1"
                     /locus_tag="MMAR_RS24570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4897"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurQ"
                     /protein_id="WP_012396427.1"
                     /transl_table=11
                     /translation="MTARIGVITFPGTLDDVDAARAIRLVGAEAVNLWHADADLKGVEA
                     VVVPGGFSYGDYLRAGAIARFAPVMGEVVSAAQRGMPVLGICNGFQVLCEAGLLPGALT
                     RNVGLHFVCRDAWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVASEQVLDELEAEDR
                     VVFRYHDNVNGSLRDIAGISSANGRVVGLMPHPEHAIEALTGPSDDGLGLFYSALDAVL
                     AA"
     misc_feature    complement(9237..9239)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9587..9826)
                     /gene="purS"
                     /locus_tag="MMAR_RS24575"
                     /old_locus_tag="MMAR_4898"
     CDS             complement(9587..9826)
                     /EC_number="6.3.5.3"
                     /codon_start=1
                     /gene="purS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_177755.1"
                     /locus_tag="MMAR_RS24575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_4898"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurS"
                     /protein_id="WP_015357291.1"
                     /transl_table=11
                     /translation="MARVVVNVMPKAEILDPQGQAIVGALGRLGHPGISDVRQGKRFEL
                     EIDDSVDDATLAEIAESLLANTVIEDWTISRDPQ"
     misc_feature    complement(10722..10736)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
ORIGIN
        1 ccagtgccag ctgggcaccg gtgtaggggt caagcagggt gtagcgcccc gaagcatcgg
       61 tcgacaacgc gataccgcga ccggtggcct cgtcgatacg cagcacgccg ccgtccgcat
      121 gttcggcgag caccgtgttg ccgcgcacgt agcggtcgta ctgctcggtg atgaacgcgc
      181 gactgcacag gtgcggactg ccaagcagcg caagcagagt cgcgcgcagc tcgtcgccgg
      241 tagccggacg gggcaggctc ttcgacgaat cggcgttgag cgcatcctgg gtctcggggc
      301 gggcgaccgg acgctggtac accgggccct cgtgggccac cgtgcgcggt ggcacgtcca
      361 cgaccgtctc gccgtgccag gtgatgcgca accggtcgcc ctcggtgacc tcaccgataa
      421 ccgtggccag cacgtcccac ttgcggcaca ccgccatgaa cgcgtccacg ttctccggcg
      481 acaccaccgc gcacatccgt tcctgcgact cgctgcagag cacctcggcg ggcgtcattt
      541 ccttggcacg cagcgggacg gtttccaggt tgatcgccat gccgccatcc ccggcggagg
      601 ccaactccga tgtggcgcac gacaaccctg cgccgccgag gtcctggatg ccgatcacca
      661 gtccgcccga gtagagctcg agacagcact cgatgagcac cttttccatg aacgggtcgc
      721 ccacctggac cgacggcaac ttcttgcgcg cgccctcgcc ctcgccatcg gagctgaagg
      781 tgtccgaggc cagcaccgat accccgccga tgccgtccag gccggtccgc gcgccgaaca
      841 ggatgatctt gtttccggcg ccggaggcga acgccaggtg caagtcctct tgacgcaaga
      901 cgcccacgca cagcgcattg accaaggggt taccggcata gcacgcgtcg aagaccgtct
      961 cgccgccgat gttcggcaac cccagcgagt tgccgtaacc gccgacaccg cggaccacac
     1021 cgtcaagcac ccggcgagtg tcgggggcat cggcggcgcc gaagcgcagt tggtccatca
     1081 ccgcgatcgg ccgcgcaccc atcgccatga tgtcgcggac gatgccgccg acacccgtgg
     1141 ccgcaccctg gtagggctcg acgtaggagg ggtggttgtg cgattccacc ttgaacgtga
     1201 cggcccaccc gtcaccgatg tcgacgacgc cggcgttctc gccgatcccg gccagcatcc
     1261 cggcgcgcat ttcatcggtg gtggtctcgc cgaaatagcg caaatggact ttggaggact
     1321 tgtaggagca gtgctcgctc cacatcaccg agtacatggc gagctcggtg tcggtgggcc
     1381 gacggcccag gatgtcacga atccgctgat actcgtcgtc tttgaggccc agctcgtgaa
     1441 acggttgcgg ctggtcggga gtggtggcgg catgtgcgac tgtgtcagtc tggtggctgc
     1501 gagcgctcgt cacgcagaca gtctagagtc ccgggccgca tcgctcccgc cggagacccg
     1561 cggcaggaaa accggctgac agcggtcggc ctggtcaaca taatggggcg atgtctcgtc
     1621 actggccgct gttcgatctg cgaatcacga cctcgcgcct acagctgcga ctgcccaccg
     1681 aagagctgtg cgaccagctg atcgacacaa ttctggacgg cgtgcacgag ccggaccgga
     1741 tgccgttttc cgtcccctgg acccgagccc ctcaggggga gctgccgtac aacaccttgt
     1801 ccttcctgtg gcgggagctg gcgggattca gccgcgatga ctgggccctg ccactggccg
     1861 tcgtggtcga gggtcgggcc gtcggtgtgc agggcttgcg cgccagcaac ttcccgatcg
     1921 ccggtgaagt cgaatccgga tcctggctgg gactgcggta ccaaggcaac ggccttggca
     1981 ccgagatgcg ggaggcagca ttgcatttcg tgttctgtga gcttggagcc caggctgcta
     2041 cctcggcagc gttcgccgac aatccggcct cgatcgcgat atcccgacgt cagggctacc
     2101 gggaaaacgg cgtcgaccga gtggcgcgag agggcgccgc ggcacagcgg gtgcgcttcc
     2161 ggttgactcg tgacgactgg ctgcgccagc gccatgtcga ggttcgggtt gaggggtttg
     2221 accgctgtcg agagctgttc ggcgtttcgc gcgcggcctg accgtcgatg ggcggtgcgc
     2281 tactggccga cgacgcagaa cacgttgccc tcgggatcgg ccatcaccac ccaccggaag
     2341 ttctccccga attggtgccg ctgcacctcg gtcgctccgg cggccgccag ccgtgacact
     2401 tcaccgtcca cgtcggcggc cgaaaagtcc aggtgtaccc ggttttttcc gggtgttgga
     2461 tcgggcacct tctgaaatcc gagccgcggc cccgccggac gcgtcaccgc gatgaactcg
     2521 ccgggcagca attcgtgcgc cgtcccgccg aagtgctcgg cccaccagcc ggccagccgg
     2581 gcgggatcac tgcagtcgaa ggtgaccatc tcgacactga gcgtcatgcc aaccgagtct
     2641 attgccgccc actattcggg cgcgtagaac gcccgtagcg ctgccgaata cgccgccacg
     2701 tcggcggcgc ccatcagctc gcgcgcggag tgcatcgcca gctgcgcggc acccacgtcc
     2761 acggtgggga taccggtgcg ggccgaggtc atcggcccga tcgtcgaccc gcacggcagg
     2821 tcggcccgat gctcgtaacg ttgcagattg acaccggcct gctgacaggc cagcgcaaag
     2881 gccgcggctg tccgcccctc ggtggcgtag cgcagattgg ggtgcacctt gagcaccggc
     2941 cccgcgttga ccgcgatctg gtggctgggc tcatggcgct cggggtagtt gggatgagtg
     3001 gcgtgcgcca tgtccgcgga cgccagcagt gaagccggca acagccgcaa caggtcttcc
     3061 cggaccccgc caccggccag cacgatcctt tccagcaccg tgttcagcag gttggactgc
     3121 gcgccgtggt ccgaggtcga gccgacctcc tcgtggtcga agatcgccag cacgggcagc
     3181 acctggtccg attcggcggc cagtagcgct tccagtcccg cgtagcaact ggcctggttg
     3241 tccagccgcg gcgcgctgag caggtcggcg ttggcaccga tgaccgcggc cggggtcagg
     3301 tcatgggtca tcagatcggc cgccagcaca tcaccctccg ccaggccggc gcgctgggcg
     3361 acgtagccga gaaaggaacc ccgctgcgca ccgacgcccc ataccgcgtt gacgtgccgc
     3421 tggggatcca gcgtgagcga cttgcgatcc tcggccaggt ggatggccag ctggggtacc
     3481 cgcaggatcg gctcatcgat ccggaccagc cggtgactga tgccgccgcg aacaccgggc
     3541 gcccgcaccg agagccgccc gctgacgccc aggtcgcggt ccagccagga gttcagccac
     3601 gctcccccgt acggttcgag cgccaccacc tgccagccgg cgaccagccg atccgggtgc
     3661 tgtttgaccc gcaggttcgg gctgtccgag tgcgccccga caatccgaaa cggtgcttgt
     3721 gcggtcccga cgccgccgct gtcccaggcg accagcgaac cggctcgaac ggtgaagtag
     3781 cggcccggct gctgcggcca gcggtctatc tcgctcagtt cggtgtaccc ggcatccagc
     3841 agacgccggg ccaccgtggc gcacagatga aacggggagg gcgacgcgtc gatgaactcg
     3901 ccgaggcctc gagcggtggc tgaagttgtg ggcgcatcgg acatgctcaa catcatggct
     3961 gttggggact gcgggattca cgctagggtc ggcagggtgc cttcggttca gccgcaaccc
     4021 atcctcgcgc ccctgacgcc agccgcaatc tttttggtgg ccaccatcga cgccggcggc
     4081 gagcagaccg tgcatgacgc gctgaccgag atatccggat tggtgcgggc catcggattc
     4141 cgcgacccca ccaagcacct gtcggtggtg gcctcgatcg gctccgacgc gtgggatcgg
     4201 ttgttctccg gcccaaagcc ggccgaactg catccgttcg tcccgttgac gggaccacgc
     4261 cacaacgcgc cggccacacc gggggacctg ctgttgcaca ttcgggccga aaccatggac
     4321 gtgtgcttcg agctggccgg ccgaatcctc aaggcgatgg ccccagcggt caccgtcgtc
     4381 gacgaggtgc acggcttccg ctttttcgac aatcgcgatc tgctgggctt cgtcgacggc
     4441 accgaaaacc ccggtggcgc aatcgcgatc ggcgcgacca ccgtcggcga cgaggatccc
     4501 gactttgccg gctcctgcta tgtgcacgtg cagaaatatg tgcatgacat ggggtcatgg
     4561 gactcgctgt cggtcaccga gcaggagcgg gtgatcggcc ggaccaagct ggaagacatc
     4621 gaactcgacg agagcaccaa gccggccaat tcccacatcg cgctcaacgt catcaccgac
     4681 gaggatggag tcgaactgaa gatcgttcgg cacaacatgc cgttcggtga ggtcggcaag
     4741 ggcgaatacg gcacctattt catcgggtat tcgcgcactc ccgtcgtcac cgaacggctg
     4801 ctgcgcaaca tgtttctcgg cgatccgccc ggaaataccg atcgcgtgct cgacttttcc
     4861 acggcgacaa ccggcgggtt gttcttctcg ccgaccatcg atttcctcga cgatccaccg
     4921 cctttgccgc cggcaccggc ggccgtccca accacggacg acggctcact ctcgatcggc
     4981 agcctgaaag gaatctccga atgaacaacc tctaccgcga tctggcaccg gtcaccgaag
     5041 ccgcttgggc cgaaatcgaa ttggaggcca cccggacatt caagcgccac atcgcgggcc
     5101 gtcgggtggt cgacgtgagc gaccccggag gtccggtcac cgcggcagtg agcacgggcc
     5161 ggctgatcga tgtgaaggct cctaccgacg gggtcatcgc ccatctgcgg gcgagcaagc
     5221 ccctggtgcg actgcgggtc ccgttcacct tgtcacgcaa cgagatcgat gatgtcgaac
     5281 gcggttccca ggactcggat tgggacccgg tcaaggcggc cgccaagcag ctggcgttcg
     5341 tggaggaccg caccatcttc gagggttacg gcgccgcatc gatcgagggc atccgcagct
     5401 ccagctccaa cccgccgctc acgctgcccg aggacccgcg cgaaatcccg gacgtcatca
     5461 cccaggcact gtcggaactg cggctggccg gcgtcgacgg accctactcg gtgctgctgg
     5521 ccgccgacgt ctacaccaag gtcagcgaga ccaccgagca cggctatccc attcgtgagc
     5581 atctgaaccg gctggtcgac ggtgacatca tctgggcgcc ggccatcgac ggtgcgttcg
     5641 tgctgaccac tcgcggcggg gacttcgacc tgcagttggg caccgatgtc gcgatcgggt
     5701 acaccagcca cgacgccgac accgtgcagt tgtacctgca ggagacgctg accttcctgt
     5761 gctacaccgc cgaagcctcg gtcgcgctca gtccgcactc gggatagctg acggaccgac
     5821 ggcggaccac gagcccggcg tcgcctgggg tttcccagcc aacttgcagc cggcgaacag
     5881 cgccagctgc gactggctga ctattactgg atacaaccgc gcggcccgaa acctccgtgg
     5941 ccgggcgcca cacccactgc ggctcgccac cgatctagca cgacgctgga aggtagccaa
     6001 acagtcgtgc accgccaacg agaggtacga agctgacgtg ctaggcccgg accaaatacc
     6061 ttcggagaaa tgggacttgc cgccgaccgt cacacccagc ggcgagcgct tcggcccgag
     6121 acgccgcccg cggcccggtc gtatggaccc cgcgggctgg caccccggca tgccctacgg
     6181 ccgccaggcg tgggatcagt accggctgga gtcccaccgc accagggcat tggtgggagc
     6241 gggccagtaa caacgcggct gagtcgtcga gaagaacagg acgaactcag cccacactcg
     6301 ccggtagcgc accagagtgc ggggcgtagc gtcgcagaga gagtcgacgg aaggatctgc
     6361 gaccgtgacc gaagacgaac gcgcccggat accggccggc gaacccgatc tttcgttcga
     6421 cgtgatagtg ctcggggccg gaccggtcgg ggagaatgcc gctgaccgct gccaggctgc
     6481 ggggctgcac gttgcggtga tcgagcgtga cctcgtcggc ggtgaatgct cgtactgggc
     6541 atgtgtaccg agtaaggcgc tgctacgtcc ggtggtcgcc gttgccgatg cccgccgggt
     6601 ggacggtgcg cgcgaggcaa tcagcgactc aatcagcgcc gcagcagttt tcgatcgccg
     6661 ggaccggtac gtgagtaact gggatgacgg cgaccaggcc gactgggtca gtggtatcgg
     6721 cgcgacgctg atccgcggcc atgggcggct ggcgggtccg cgtcgagtca gtgtgtccga
     6781 tcacgacggc cagacgctga tgatcgcggc gcggcatgcg gttgtcgtct gcaccggaag
     6841 tcgccccacc ttgcccgacc tccctgggat caccgaggcc tggccgtgga ccaatcgcca
     6901 agccaccgag gccagttcgg tgccccgccg gctcgcgatc gtcggcgcgg gcggtgtggg
     6961 tgtcgaaatg gcgaccgcct ggcaaggatt ggggtcgtcg gtgatcctgc tggcgcgatc
     7021 ccgattgctg agccggatgg aaccgtttgt cggcgacttc gtcggccgcg gtctcacccg
     7081 ctcgggtgtc gatgtgcgcg tggggatctc agtgcgcgca ctgcaccggc cgcatcccga
     7141 tgcaccggtt accctcgaac tcgatgatga tacgcggctc gaggtcgacg aggtgttgtt
     7201 cgctaccggc cgcgcaccac gcaccgacga catcggcctg cagacggtcg ggctggcgcc
     7261 gggcaactgg ctcgatgtcg acgacacctg ccgagtgaac gccgtcgatg gcggttggct
     7321 ttatgcggcc ggcgatgtca atcaccgcgc actgctcacc catcagggca agtaccaagc
     7381 ccgcatcgcc ggtagcgcta tcggtgcccg cgccgccgga gactcgctgg acaccgcacc
     7441 gtggggtgcg catgcgacca ccgccgatca tcacgcggtg ccacaggctt tcttcaccga
     7501 ccccgaagcc gccgcggtgg gactgacggc cgagcaggcg gcgcgggccg gtcatcggat
     7561 caagacgatc gacgtcgaca tcggcgatgt cgtcaccggg gccaagctct tcgccgacgg
     7621 ctacgccggc cgggcccgca tggtcgtcga cgtcgaccga ggttgcctcc tcggtgtcac
     7681 catcgtcggc ccgggcgccg cggagttgct gcacgcggcc accatcgcca tcgccggcca
     7741 agtgcccatc gaccggctgt ggcacgccgt accttgcttt ccaacgatca gcgaactgtg
     7801 gctgcgactt ctcgaggcct accgcgattc gtttttcgtc cttgtctagc actcacccaa
     7861 caatcggagc agccatggcg acctcggacg gattccatcc cgacttccca gccgagacag
     7921 ccgccccgga ccgccgtcgc gcgcaggtac accacatcaa ggcctccgaa atcagttccg
     7981 ataccgcgca atcggaggga ttgcgccggt ttgccgcgct tagcggaagg tcggtgggcg
     8041 cggagaagat ctggatgggt gagacgcatg tcctgccccg gacggtctcg gccaaccatc
     8101 accacggaga ctccgaaacc gcaatctatg tgcgaagcgg acgcccggag tttgtgtttc
     8161 acgacggcga gcaagaggtg cgtatcgcta ccgaacccgg cgactacatc ttcgttccgc
     8221 cctatctgcc acaccgggaa gaaaatcccg acccgaccat gcccgccgag gtggtcatcg
     8281 cgcgcagcac ccaggaggcg atcgtggtca acctgccggg gctgtatccg ctctcgtaac
     8341 cggcaagcag cagccactca ggaaattctc aactgattct ttggatccgc tttccttggc
     8401 tccaaggatc tgcatagccg cagcgcggag catggattca tgaccgagcc actgtgcgca
     8461 accctgatcg aacgctactt gtgcacccgt ggaaggcggt atttccgcgg ccagcacgac
     8521 ggcgagttct tcttcgtcac cgacgcccat ccccagcggc tgcacgtcca cctggagatc
     8581 tcaccggcgc atccggaagt gttcgcgatt cgggtcgctc ccgcatgctt tttccccgcg
     8641 ggcgaccgtg cgctgctggc gcggttcgcc gaccgctgga acacccagcg tcgcggagtc
     8701 accgcgatag tgcacaactc gtctgaccca cagcgcatcg gcgtcaccgc ctacaagtcc
     8761 caatggatcg ccggtccggt ggacttcagc gaattcgccg tattcgtgga ccgcgccatc
     8821 ggcgcatcga tcgagctgtt tggcgagttg aaccgggtcg ccgagctgcc gcagacgccg
     8881 ccgctgatgc gcgacgccgg ctgatccggc cgacctcagg cggccagcac cgcgtccagc
     8941 gccgaataga acagtccgag cccgtcatcg gaggggccgg tcagcgcctc tatcgcgtgt
     9001 tcggggtggg gcatgagccc gaccacccgg ccattggcgg agctgatccc ggcgatgtca
     9061 cgcagcgagc cgttgacatt gtcgtggtag cggaacacca cccggtcttc ggcttccagc
     9121 tcgtcgagca cctgttctga ggccacatag cggccctccc cggacttgag cggcaccagc
     9181 aagtccgcgt ccggttcgaa acgcgatgtc caggcggtcg acgtcgacgc cacccgtaac
     9241 catgcgtcgc gacagacgaa gtgcagcccc acattgcggg tcagcgcgcc gggcagcagg
     9301 ccagcctcgc acaacacctg gaaaccattg catatcccca ggaccggcat gcctcgctgc
     9361 gcggcgctca ccacttcgcc catcaccggg gcaaacctgg cgatcgcacc cgcccgcagg
     9421 tagtcgccgt aggagaagcc gccgggcacc accacggcct cgacgccttt cagatccgcg
     9481 tcggcatgcc agagattcac cgcctcggcg cccaccagcc ggatcgcgcg ggcggcgtcc
     9541 acgtcgtcca gcgttccggg aaatgtgata accccgatcc gagctgtcac tgcgggtccc
     9601 ggcttatcgt ccaatcctcg atcaccgtgt tcgccaacag cgattccgcg atttcggcca
     9661 gcgtggcatc gtccacgctg tcgtcgatct ctagctcaaa tctcttgccc tggcggacat
     9721 ccgagattcc gggatgcccg agacgcccca gggcgccgac gattgcctgg ccctgcgggt
     9781 ccagaatctc cgctttgggc atcacattga cgaccacccg ggccaccggc attcctcctc
     9841 agctccgatt gctcggcgcc aactctaccg gcgatggcct ccggggcgcg tcacgggcgc
     9901 gagtccgctg ctgccggccc gtgagaacaa ccgaccgaag acgcgctgtt cgccgatccg
     9961 gtgacggcat acccatcgag atcggtgtgc gatcacacct aagccacccg acggtttcgc
    10021 tgcgttgtgt cgcttcgccg gcgccggttc accgacgcga cgcccgcacc ctgatgccgg
    10081 caaccagcta accccgtttg ttcaccaagc gtccgtactg tggcggcgat ttgtcggatt
    10141 tcgggaggac tattatgacg gcgtctgttt ggatggcctc gccgccggaa gtgcattcgg
    10201 ctttgctgag cgcgggcccg ggcccgggcc cgctgcacga ggccgctgcg gcatggacgg
    10261 cgctggccgc cgaacacgcc ttggccgcag aggaactcac caccatgctg ggtgagtcgg
    10321 ccgtggcgtg ggaggggccg agcgcgcaga gttatgtcga tgcccatgtg ccgtatctga
    10381 cgtggttgac caagaccagc gccgactacg cggcgacggc ggccgagcac gaggcggcgg
    10441 cgggggccta cgccagtgcg ctggcagcaa tgccgacact ggcggagttg accgccaacc
    10501 gcaccaccca tgcggcgctc gtcgcgacca atttttttgg actcaacacc atccccataa
    10561 cgctcaacga agtcgactac gcgcggatgt ggatccaagc ggccaccacc atgagcgcct
    10621 atcaggcggt ctcaggcacg acgctggcct cgatgcccca caccacaccg gccccgctca
    10681 tactcgaggc cgaaaccagc acgcccgcca ccgcccagaa aatcgacatc atcgatttaa
    10741 tcatgtggct gatcatgaat attctgtact attcgatcat cttgggcgtg tatttatatg
    10801 taatcgt
//
