LOCUS       NC_010612              21704 bp    DNA     circular CON 17-DEC-2024
DEFINITION  Mycobacterium marinum M, complete sequence.
ACCESSION   NC_010612
VERSION     NC_010612.1
KEYWORDS    RefSeq.
SOURCE      Mycobacterium marinum M
  ORGANISM  Mycobacterium marinum M
            Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
            Mycobacteriaceae; Mycobacterium; Mycobacterium ulcerans group.
REFERENCE   1  (bases 1 to 6636827)
  AUTHORS   Stinear,T.P., Seemann,T., Harrison,P.F., Jenkin,G.A., Davies,J.K.,
            Johnson,P.D., Abdellah,Z., Arrowsmith,C., Chillingworth,T.,
            Churcher,C., Clarke,K., Cronin,A., Davis,P., Goodhead,I.,
            Holroyd,N., Jagels,K., Lord,A., Moule,S., Mungall,K.,
            Norbertczak,H., Quail,M.A., Rabbinowitsch,E., Walker,D., White,B.,
            Whitehead,S., Small,P.L., Brosch,R., Ramakrishnan,L.,
            Fischbach,M.A., Parkhill,J. and Cole,S.T.
  TITLE     Insights from the complete genome sequence of Mycobacterium marinum
            on the evolution of Mycobacterium tuberculosis
  JOURNAL   Genome Res 18 (5), 729-741 (2008)
   PUBMED   18403782
REFERENCE   2  (bases 1 to 6636827)
  AUTHORS   Stinear,T.P., Seemann,T., Harrison,P.F., Jenkin,G.A., Pidot,S.J.,
            Davies,J.K., Small,P.L.C., Johnson,P.D.R., Brosch,R., Cole,S.T.,
            Ramakrishnan,L. and Parkhill,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-AUG-2007) Pathogen Sequencing Unit, Wellcome Trust
            Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
            CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000018345.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 14:09:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,598
            CDSs (total)                      :: 5,546
            Genes (coding)                    :: 5,407
            CDSs (with protein)               :: 5,407
            Genes (RNA)                       :: 52
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 53 of 139
            Pseudo Genes (incomplete)         :: 113 of 139
            Pseudo Genes (internal stop)      :: 14 of 139
            Pseudo Genes (multiple problems)  :: 34 of 139
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:27
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1869352
            Orig. end                         :: 1891056
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000854.1.
            DNA and bacteria are available from Dr Lalita Ramakrishnan,
            lalitar@u.washington.edu.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21704
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cytokinin"
                     /region_number="11"
                     /rules="(IPPT and Lysine_decarbox)"
                     /tool="antismash"
     cand_cluster    1..21704
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(IPPT and Lysine_decarbox)"
                     /kind="single"
                     /product="cytokinin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21704
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11704](-)"
                     /cutoff="20000"
                     /detection_rule="(IPPT and Lysine_decarbox)"
                     /neighbourhood="10000"
                     /product="cytokinin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11704)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(IPPT and Lysine_decarbox)"
                     /neighbourhood="10000"
                     /product="cytokinin"
                     /protocluster_number="1"
     misc_feature    complement(201..216)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.9"
                     /tool="antismash"
     gene            complement(253..1116)
                     /locus_tag="MMAR_RS07660"
                     /old_locus_tag="MMAR_1551"
     CDS             complement(253..1116)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011725798.1"
                     /locus_tag="MMAR_RS07660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1551"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_012393387.1"
                     /sec_met_domain="PhyH (E-value: 1e-29, bitscore: 102.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIDDEAVTTLEDLKGDLAHRYKWTPSGGSSVDSATIEADMAALD
                     RDGYVIWENLLSAEQCRLIREVVRPWLEHTGRNSFEGRRTQRIYSVLSRTRVCDRLADH
                     PRVLAVLDRILMPNYLLSALQAINILPGEDAQLPHHDDGFYPIPRPRAPLAAATIWAID
                     DFTADNGATVVIPGSHRWGRRPPGPDDQVLPVVMSAGSCVFFVGTLWHGGGANTSTSER
                     LAVTAQYCEPWLRPMEAYTLSISREIARAVSDDIRRMLGYSIHPPFVGAVDGLHPLRLL
                     ESGPDS"
     gene            1257..1571
                     /locus_tag="MMAR_RS07665"
                     /old_locus_tag="MMAR_1552"
     CDS             1257..1571
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015354997.1"
                     /locus_tag="MMAR_RS07665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1552"
                     /product="hypothetical protein"
                     /protein_id="WP_012393388.1"
                     /transl_table=11
                     /translation="MKTLLSALSLVIALAGPAALPGIIATAQAEPVMFEPDWPNHQEQA
                     EQTICLALAQGWPRTQIVDVAEHANDIDQTGLSVPEAARLADTWIDEAHNTLCPTLALD
                     "
     gene            1778..2266
                     /locus_tag="MMAR_RS07670"
                     /old_locus_tag="MMAR_1553"
     CDS             1778..2266
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012393389.1"
                     /locus_tag="MMAR_RS07670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1553"
                     /product="LppP/LprE family lipoprotein"
                     /protein_id="WP_012393389.1"
                     /transl_table=11
                     /translation="MRIVGWAATVAVLAALNPLAPPAKAEPTCGVNLNAPEIQAAIKSL
                     PTLPQSYPWDTNPRSFDPSSNYNPCSTLSAVIISVEGATGSSPDLVLLFHNGTSAGIAT
                     TKAYSFTTLNAAKTTDDTVALDYKDGRDVCTACPGPITTVRYEWKGDHVAMLDPAPAW"
     gene            complement(2280..3416)
                     /locus_tag="MMAR_RS07675"
                     /old_locus_tag="MMAR_1554"
     CDS             complement(2280..3416)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0000272 - polysaccharide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_217612.1"
                     /locus_tag="MMAR_RS07675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1554"
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="WP_012393390.1"
                     /transl_table=11
                     /translation="MQRRTALKLPLLLAAGAALAQPPRATAVAGRWSAERANTWYQTQG
                     WIVGANYITANAINQLEMFQPATYDPRRIDRELGLARLIGFNSMRVFLHDQLWASDQRG
                     FQTRLAQFVAIAARHGIKPLFVLFDSCWDPFPKLGQQRAPRPGVHNSGWVQSPGAEHLG
                     DPSYQAVLHGYVTGVLNQFRNDNRVLGWDLWNEPDNPAKVYRKVERKDKLERVAELLPQ
                     VFQWAREVDPSQPLTSGVWQGNWSDPGKRSTIASIQLDNADVITFHSYAAPAGFEARID
                     ELAPLGRPIICTEYLARSQGSSVEGVLPIAKRRNVGAFNWGLVAGKTQTYLPWDSWDHP
                     YTKPPKVWFSDLLQPDGRPYRESEIQTIQSLTGARTQD"
     misc_feature    complement(3393..3411)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
     misc_feature    3502..3517
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.55"
                     /tool="antismash"
     misc_feature    complement(3503..3515)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     misc_feature    3620..3635
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(3677..4153)
                     /locus_tag="MMAR_RS07680"
                     /old_locus_tag="MMAR_1555"
     CDS             complement(3677..4153)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020786388.1"
                     /locus_tag="MMAR_RS07680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1555"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_012393391.1"
                     /transl_table=11
                     /translation="MGAADLSHRFEGESVGRALELVGERWTLLILREAFFGVQRFGQLA
                     RNLNIPRPTLSSRLRMLVNAGLLDRVPYSQDPERHEYRLTDTGHELFAAIVVLMQWGDK
                     HLPNPDGPPIVLRHHCGQFVEPRLICAHCGEEITARNVTPEAGPGFGDAVAAPN"
     misc_feature    complement(4176..4190)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.53"
                     /tool="antismash"
     gene            4233..5393
                     /locus_tag="MMAR_RS07685"
                     /old_locus_tag="MMAR_1556"
     CDS             4233..5393
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020732303.1"
                     /locus_tag="MMAR_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1556"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_012393392.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.3e-06, bitscore:
                     26.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.4e-10, bitscore:
                     39.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPDLSAAPLRRADSEMENLAEKIALTAREMSAEIDRDRRLPDE
                     LVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASAGWCVSIAITSALLVAY
                     LPASSRDEMFGAGRSVAAGVWAPRGKAKSVDGGVVVSGRWPFCSGINHADMMFAGCFVE
                     GQPVPSVVALPKDDLRALDTWHTLGLRGTGSHDCVAEEVFVPADRVFSVFDGPSIDRPL
                     YRFPVFGFFALSIGAAALGNARAAIDDLVELAGDKKGLGAKRTLAERSATQTAVATAEA
                     ALGAARALFYEAIDSAWQASHNPDPVPVALRNRLRLAATHAARTSADVVRIMYDLAGSS
                     AIYDGSPLQRRFRDAFTATAHFQVNEASRELPGRVLLGQHCDTSML"
     gene            5390..6367
                     /locus_tag="MMAR_RS07690"
                     /old_locus_tag="MMAR_1557"
     CDS             5390..6367
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020727118.1"
                     /locus_tag="MMAR_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1557"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_012393393.1"
                     /transl_table=11
                     /translation="MTDLEVALPFWLDRPDDEAMEVALAASNAGFDVLWVGEMATYDAF
                     ALATAIGLGAPGMGLKIGPLAVAVRGPVGLALGVSSVASLTGSRVDIALGASSPAIVAG
                     WHDRPWAHHVPVMRETIECLRSILGGARVDYHGRHVASHGFRLRNPQPEARIALGAFGP
                     GMIRLAARHADEVVLNLASPARVAEVRHAIDSAAAAAAGRAAPRLTVWVPVAVDPGAAA
                     HAQLAAQLAVYLGPPGYGEMFSALGFDRLVGAARAGASRRELAAAIPVELLEQVGALGT
                     AERVAARLRDYEAAGADCLALVPCTAEDPAGRATLNALSRKGES"
     misc_feature    5399..5401
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6364..7371
                     /locus_tag="MMAR_RS07695"
                     /old_locus_tag="MMAR_1558"
     CDS             6364..7371
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016628 - oxidoreductase activity, acting
                     on the CH-CH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (32-332). E-value: 1.1e-19.
                     Score: 62.7. Matches aSDomain:
                     nrpspksdomains_MMAR_RS07695_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020732305.1"
                     /locus_tag="MMAR_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1558"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_012393394.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.7e-20, bitscore:
                     70.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVNTVCRLAARPIGLPKPSDWEVADEPVGGPADGEFLVRVEYL
                     SVDPAMRTWMNAGRSYVAPVQIGEVMRAGGIGRVIDSRHPDFAAGDEVYGMFGVQRYAH
                     SDGSGVTRVDTTLAPAPVHLGALGISGITAYFGLLDVGRPQPGQTVVVSGAAGSVGSIV
                     GQVARIVGCRAIGIAGGEQKCRWLVEELGFDAAIDYQAGDLRRQLKMHAPNGIDVFFDN
                     VGGEVLEAGLSRLARGARVVICGAISQYNAAGELHGPANYMQLLVARASMTGFVVFDYA
                     DRYGEAVGQLANWLASGELRAREQVVAGDVGDFPEVLLALFRGENTGKLVLALR"
     aSDomain        6460..7359
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MMAR_RS07695_PKS_ER.1"
                     /evalue="1.10E-19"
                     /label="MMAR_RS07695_PKS_ER.1"
                     /locus_tag="MMAR_RS07695"
                     /protein_end="332"
                     /protein_start="32"
                     /score="62.7"
                     /tool="antismash"
                     /translation="PADGEFLVRVEYLSVDPAMRTWMNAGRSYVAPVQIGEVMRAGGIG
                     RVIDSRHPDFAAGDEVYGMFGVQRYAHSDGSGVTRVDTTLAPAPVHLGALGISGITAYF
                     GLLDVGRPQPGQTVVVSGAAGSVGSIVGQVARIVGCRAIGIAGGEQKCRWLVEELGFDA
                     AIDYQAGDLRRQLKMHAPNGIDVFFDNVGGEVLEAGLSRLARGARVVICGAISQYNAAG
                     ELHGPANYMQLLVARASMTGFVVFDYADRYGEAVGQLANWLASGELRAREQVVAGDVGD
                     FPEVLLALFRGENTGKLVL"
     gene            complement(7393..8868)
                     /locus_tag="MMAR_RS07700"
                     /old_locus_tag="MMAR_1559"
     CDS             complement(7393..8868)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020786392.1"
                     /locus_tag="MMAR_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1559"
                     /product="hypothetical protein"
                     /protein_id="WP_041324489.1"
                     /transl_table=11
                     /translation="MGDRIDASALVLGHGDDVRRRLTRSVAVLRQMVEAGWFAGHEDTI
                     GMEVELDLVDPLGRPRLVNDAVLQALDRTDMQHELGQFNVELNLPPHPLTGHVLRDSEQ
                     LLADVLDGSGARIESLGTRLIAVGMLPTLSADHMTAERLSTNPRYELLSRRIRTARHRP
                     FRVHISDAPEPVEFTTDSVAPEASATSLQLHLRAHRDRFAAYFNAAQLIAGAQVAVAAN
                     SPFLLGRHAWQETRITLVEQLLDSRRPSEVKASAPARVRLGEGWISDPVDLFDHLVREY
                     PPLFPTLEAEDPDAALEAGQAPVLHELRLHNGTVWQWNRPVYDVQGGSPQLRIENRVLP
                     SGPTAVDMVANAAFYYGLVRAIADSDRTPWEQTPFAVAERDLHRAARDGLAAQLSWQGT
                     DQPAAQLTRDVLLPAAASGLDAWGVDAHDRDRYLGVIEARVRSGRTGAAWQTETVRHLE
                     ERGLERISALHEMTRRYVEHARSGAPVHEWPLS"
     gene            complement(8934..9914)
                     /locus_tag="MMAR_RS07705"
                     /old_locus_tag="MMAR_1560"
     CDS             complement(8934..9914)
                     /EC_number="3.6.1.9"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015355003.1"
                     /locus_tag="MMAR_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1560"
                     /product="nucleoside triphosphate pyrophosphohydrolase"
                     /protein_id="WP_012393396.1"
                     /transl_table=11
                     /translation="MTVVLIDPHYLLVPMEALEVLRQQVQYTEEIPAALTRLLPAARPV
                     RAGSHATVLLSSDPTHPAVTARLVAGDRLISIPHPQCGERLIDAVAAVDELRTAGSWEA
                     AQTHVSVSRYLLSQTYALLDALRSADAGQLREELGALLLQVLFQARIAQDAPRRPFTID
                     DVADTLIRKLGNRRRGVLAGNSPSFQEQVAQWEKGKKADKRAGSVMHDLFHGQPALALA
                     QKVIERAVRAGLPMDLVPATLTSVVVSPDIDAEGELRAAVLEFMDSVRRAEDTIAARRR
                     APDATEEPDRTALGGITEREWRMCWPSVGAHTQSGVRVAKPRDDA"
     misc_feature    complement(9940..9950)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     gene            complement(10001..10945)
                     /gene="miaA"
                     /locus_tag="MMAR_RS07710"
                     /old_locus_tag="MMAR_1561"
     CDS             complement(10001..10945)
                     /EC_number="2.5.1.75"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0052381 - tRNA dimethylallyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="miaA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cytokinin: IPPT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010908061.1"
                     /locus_tag="MMAR_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1561"
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="WP_012393397.1"
                     /sec_met_domain="IPPT (E-value: 1e-74, bitscore: 249.6,
                     seeds: 863, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPLTIIGPTGTGKSDLAIEIADRLSGKIAVEIVNADAYQLYRGM
                     DIGTGKVPLAQRRGIPHHQLDVLDVTETATVAGYQRSAAADIEAIASRGALPLLVGGSM
                     LYVQSLLDDWAFPAKDPAIRARWERRLAQVGPARLHAELVRRDPAAAAVIPLNDARRTV
                     RALEVVEITGRPYAASAPRIGSPRWDSAIIGLDCETKVLDERLAARTKAMFDRGLIEEV
                     ISLLPCGLARGVTASRALGYAQVMEALKAGADTQALDSARQQTCLATRRYVRRQRSWFR
                     RDRRVRWLDATVSTAAHRTAIIEAVLGAWRRAS"
     misc_feature    complement(10361..10363)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10895..10897)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11114..11704)
                     /locus_tag="MMAR_RS07715"
                     /old_locus_tag="MMAR_1562"
     CDS             complement(11114..11704)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009691 - cytokinin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cytokinin: Lysine_decarbox"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_215721.1"
                     /locus_tag="MMAR_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1562"
                     /product="TIGR00730 family Rossman fold protein"
                     /protein_id="WP_237708438.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 5.3e-39,
                     bitscore: 131.7, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCVYCASGGDNPADLSLAAAVGTEIGRRGWRLISGGGTIAMMGAV
                     ARAARTAGAHTTGVIPRMLLQSELADLGADELIVTDTLTQRKHLMGERADGFLTLPGGL
                     GTLEELLECWTAASLGIHHKPVVLLDPAGHYRGLLDWLEELRQQGFVRTAAIDRLIVTT
                     DVDSAFSNLCPSTRSAFASSGEASVSERTHAHY"
     gene            complement(11878..12339)
                     /locus_tag="MMAR_RS07720"
                     /old_locus_tag="MMAR_1563"
     CDS             complement(11878..12339)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.5"
                     /locus_tag="MMAR_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1563"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_012393399.1"
                     /transl_table=11
                     /translation="MIPSANRLRLFSWPRGKALHSCLYAEVQQFYARQMRLLDLRDIGS
                     HAKTFTKDATFEHIPGAGPVSTRAAIEKALLKWDSRAGDAIQRRHWLSMIDLASRSAGV
                     IEASAYLIEINTRPGTKPAIAQSCVIHDKLTRVSGQLLISSRKVLEDGL"
     gene            complement(12336..13571)
                     /locus_tag="MMAR_RS07725"
                     /old_locus_tag="MMAR_1564"
     CDS             complement(12336..13571)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012393400.1"
                     /locus_tag="MMAR_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1564"
                     /product="cytochrome P450"
                     /protein_id="WP_012393400.1"
                     /sec_met_domain="p450 (E-value: 7.6e-21, bitscore: 72.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTMLARFDPHDQQLRDDPYAVYATYRQADPVHWGQPFKPGDNG
                     CWYLFRHDHVVAMLRDPRFRRKLVPADPLASGRVFGAPRGFAELSGRLLLSLDPPHHGR
                     LRSIVAPTFTPSAIESYRMIAAKAADRLIDGLDEATAFDVIDNYAVPLSMTLIAAMLGL
                     TADELHPDLPVWVSRFGDGFDLRKEPAAIARADDAAANMLWFFETAAASHDRLRPGLIS
                     ALIAAREAGQLTHEELLALCVQLMFAAHGTTVAQIGNMIADLWTRPDQLALLRAHPELM
                     AAAVNESLRFNGSVQSTAARKPIEDVTLGGAHIRAGQPVIAFVGAANRDPKVFEEPDRF
                     DITRARGAAVMFGAGIHYCLGARLARLECQIAVGTLMRRLPRLKLTERTQLHRHTNIVL
                     PALLHLKAVTAA"
     misc_feature    complement(12924..12926)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(13624..13638)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            complement(13642..14490)
                     /locus_tag="MMAR_RS07730"
                     /old_locus_tag="MMAR_1565"
     CDS             complement(13642..14490)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015355008.1"
                     /locus_tag="MMAR_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1565"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_237708406.1"
                     /transl_table=11
                     /translation="MSEARRTSIAALYDRKTRDCDGLNAMLASRDGLFFNHNGIDLPDG
                     PAPMQEKARLDWLHRSEAELVSFGLKFLGKPPSDGTVLDAGCGAGGGAIMIHQRFGCAV
                     EGVTVSPEQARFAAATALVRGVEDQVRFRVGDMLEVDRRLGSGQIRHRYQAVWACESTE
                     HVDDLGLMFTTFGRVLVAGGQIVVIAWCAGRGRAAESVKQRVDDQYCTNIHEPADYRRA
                     ADEAGLITCRQVDLTGLTVPYWKTRLGSAHVTGTEELMHSAFAQRLMTYELFSFKTPGE
                     P"
     misc_feature    complement(14591..14601)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(14707..16191)
                     /gene="miaB"
                     /locus_tag="MMAR_RS07735"
                     /old_locus_tag="MMAR_1566"
     CDS             complement(14707..16191)
                     /EC_number="2.8.4.3"
                     /GO_function="GO:0016782 - transferase activity,
                     transferring sulphur-containing groups [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="miaB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019048040.1"
                     /locus_tag="MMAR_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1566"
                     /product="tRNA (N6-isopentenyl
                     adenosine(37)-C2)-methylthiotransferase MiaB"
                     /protein_id="WP_041324497.1"
                     /sec_met_domain="PF04055 (E-value: 2.5e-29, bitscore:
                     101.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAHDSERMAGLLEDAGYIKADPGAPADLVVFNTCAVRENADNKL
                     YGSLAHLAPIKASRPGMQIAVGGCLAQKDRHIVLDRAPWVDVVFGTHNIGSLPVLLERS
                     RHNQDAQVEILESLRTFPSALPAARDSAYAAWVSISVGCNNSCTFCIVPSLRGKEADRR
                     PGDILAEVQALVEQGVLEVTLLGQNVNSYGVNFADPDPSTGEEPLPRDRGAFAQLLRAC
                     GRIEGLERIRFTSPHPAEFTDDVILAMAETPAVCPHLHMPLQSGSDQILKAMRRSYRRD
                     RYLGIIDKVRAAIPHAAITTDIIVGFPGETEHDFEQTLDVVQKARFTSAFTFQYSPRPG
                     TPAADMPDQIPKNVVQQRFERLVALQERISLESNRSLVGTRQELLVVAGEGRKNATTAR
                     ISGRARDGRLVHFRPDSADGSVRPGDLVDVEITDAAPHHLIADGPLLQHRRTPAGDASE
                     RGQTPTTRGVGLGVPRITVAQAQIPSSGTHPDTACR"
     misc_feature    16427..16447
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.88"
                     /tool="antismash"
     misc_feature    complement(16428..16448)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.65"
                     /tool="antismash"
     misc_feature    16968..16985
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            17132..18049
                     /locus_tag="MMAR_RS07740"
                     /old_locus_tag="MMAR_1567"
     CDS             17132..18049
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015355011.1"
                     /locus_tag="MMAR_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1567"
                     /product="DUF808 domain-containing protein"
                     /protein_id="WP_012393403.1"
                     /transl_table=11
                     /translation="MSAGLFGLLDDVAALARLAAASVDDVGSAAARATAKAAGVVVDDT
                     AVTPQFVHGITAERELPIIKRIALGSLRNKLVFILPGAMLLSQFVPWLLSPILMLGATY
                     LCYEGAEKLWSALRGNGSQARRPKDEQQVVTGAIRTDVILSAEIMVIALSEVADLAFLP
                     RLVVLIVVALVITGAVYGVVAAIVKMDDVGLRLAETSSRVGQRLGRALVAGTPRLLSMI
                     AAVGTVAMLWVGGHILLVGSDQIGWHTPYGLVHHLDEQVRHAVGSLGTVVAWLVNTGVS
                     AALGLIVGAVAVTLVHLLPFRRVG"
     gene            complement(18066..18869)
                     /locus_tag="MMAR_RS07745"
                     /old_locus_tag="MMAR_1568"
     CDS             complement(18066..18869)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (10-169). E-value: 5.2e-10.
                     Score: 31.5. Matches aSDomain:
                     nrpspksdomains_MMAR_RS07745_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012393404.1"
                     /locus_tag="MMAR_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1568"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_012393404.1"
                     /transl_table=11
                     /translation="MDLGFSGSKAVVTGGSKGMGLAIAETLAAEGASVAVIARGKRALD
                     SAVERLSQAGAPDAVAISADMADAASITSAFAAVSERWGQLNCLVHTIGPGDGYFEELD
                     DAAWDAAFTLGTMSGVRAIRAALPLLRAADWARVVTLSAHSIQRQNPRLVAYTASKAAL
                     SSVTKNLSKSLAKEGILVNCVCPGTIVTASFTEQLKDLLAADGLDATNPYDVMAWIDKY
                     FHQPCDLGRAGLPEEVASITAYLVSRRNGYVTGATVNADGGSDFI"
     aSDomain        complement(18363..18839)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MMAR_RS07745_PKS_KR.1"
                     /evalue="5.20E-10"
                     /label="MMAR_RS07745_PKS_KR.1"
                     /locus_tag="MMAR_RS07745"
                     /protein_end="169"
                     /protein_start="10"
                     /score="31.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVTGGSKGMGLAIAETLAAEGASVAVIARGKRALDSAVERLSQAG
                     APDAVAISADMADAASITSAFAAVSERWGQLNCLVHTIGPGDGYFEELDDAAWDAAFTL
                     GTMSGVRAIRAALPLLRAADWARVVTLSAHSIQRQNPRLVAYTASKAALSSVTKN"
     CDS_motif       complement(18774..18839)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MMAR_RS07745_0001"
                     /evalue="4.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="MMAR_RS07745"
                     /protein_end="32"
                     /protein_start="10"
                     /score="16.2"
                     /tool="antismash"
                     /translation="VVTGGSKGMGLAIAETLAAEGA"
     gene            complement(18902..19669)
                     /locus_tag="MMAR_RS07750"
                     /old_locus_tag="MMAR_1569"
     CDS             complement(18902..19669)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011741233.1"
                     /locus_tag="MMAR_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1569"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_012393405.1"
                     /transl_table=11
                     /translation="MSDIAATMKCRLRVSRKRLVGTYGSMTHPNNPGTRRQADLSSRLT
                     RRRHKLAPDPGIRRAILVAASMSVREHGVRGLSVATVLDRAQLSTRAFYRHFESKDQLV
                     AAVFLEVARVEAVRLRTLMAKATNPIEGVAAWIDGRLDLAFDDAVKADLRHLSMDAQSH
                     LLNTPELVEPAYAETLEPLIEQLHLGVAQEVFHDVDPHSEARSIQGVVWANTEQQWASG
                     DCRRDEVRESTVRFCLRGLGVAPDTIAQITAPD"
     gene            complement(19723..20358)
                     /locus_tag="MMAR_RS07755"
                     /old_locus_tag="MMAR_1570"
     CDS             complement(19723..20358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020732315.1"
                     /locus_tag="MMAR_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MMAR_1570"
                     /product="DUF732 domain-containing protein"
                     /protein_id="WP_020732315.1"
                     /transl_table=11
                     /translation="MAEPVPASDKTAALDGDKTAAVPSPAPTDTVETAWSREQDVSDVR
                     DPGPDLPDVPDIPDGRGEELAAEPASLVQSWRTTLARAAALLLLGLGFAAVIVIGGWAL
                     STESSPGKASKPRSVTQIAPTPTSAPTTTTTIASTPEQDSAYIAALNDRGISFANPNAA
                     IYNGKLVCENFRRGLTVDEIVAAFRSSNPALSNHAGDYVDISMRTYCP"
     misc_feature    20343..20357
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    20573..20585
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    20686..20701
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.55"
                     /tool="antismash"
     misc_feature    complement(20822..20838)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.7"
                     /tool="antismash"
ORIGIN
        1 gtaattttaa tgactgactt ggcggcatgt tgccgccttt gaagagaaaa gctcgaccgc
       61 atcgtcgacg cggtggcgtc ggccgggctc ggatgcccgc ggtttgcgcg acgcccgtga
      121 ccagtgtttc gcgtcagggc ggggacgtgt tcatttgcgg tccttcgcgg tagtcaggcc
      181 gaagacggtt cggatgattc gcgaaatatt tgcattcgct cgcggctacc aatcccaaca
      241 acgcatccaa acctaggaat caggcccgga ctccaacagt cgcaatgggt gcaggccatc
      301 aaccgcgcca acgaacgggg gatggatgct gtagccgagc atccggcgaa tgtcgtcgga
      361 gaccgctcgg gcaatttcgc gcgatattga cagggtgtag gcctccatcg ggcgcagcca
      421 cggttcgcag tactgggcgg tgacggccag acgctcgctg gtgctggtat tggcgccacc
      481 accatgccag agggtgccga cgaagaagac gcacgagccg gcagacatca cgacgggcag
      541 cacctgatcg tccgggcccg gcggacgtct gccccaacga tggctgccgg ggatgaccac
      601 cgtggcgcca ttgtcggcgg tgaagtcgtc gatcgcccag atcgtcgccg ccgccaacgg
      661 tgccctgggc cgcggaatcg ggtagaaccc gtcgtcatgg tgaggtagct gcgcgtcttc
      721 tccgggcaga atgttgatcg cctgcaatgc cgaaagcagg tagttgggca tcaatatccg
      781 atcgagcacc gccagcaccc gtggatgatc ggcaagccgg tcgcacactc gcgtcctgct
      841 caacacgctg tagatgcgtt gggtgcgccg gccctcaaac gagttacgtc cggtgtgctc
      901 gagccagggt cgcacgacct ctcggatcag ccggcactgc tcggcactga gcaggttctc
      961 ccagatgacg tagccgtcgc ggtcgagggc cgccatgtcg gcctcgatgg tcgcgctgtc
     1021 gaccgagctt ccgccgcttg gcgtccattt gtagcggtgc gccagatcgc ccttgaggtc
     1081 ttccaaggtt gtgacggctt cgtcatcaat gctcattggc actcgtcctt ttcccgctgg
     1141 caccaacggc ggccagccct gcgcggcgac ggctcgcacc accacagtaa gccgacgatg
     1201 gccggaaatg ggtcagacca ggcggcggct gacggctcga tcggtaccct ggcgccatga
     1261 agacgttgct gtcagccctg tcgctggtga tcgcgctggc tggtccagcc gcacttccgg
     1321 gcattatcgc cacggcccag gccgaaccgg tcatgttcga gcccgactgg cccaatcacc
     1381 aggagcaagc cgaacaaacg atatgcctgg ctctggcgca aggctggcca cgcacccaga
     1441 ttgtcgacgt cgccgaacac gcaaacgaca tcgaccagac gggactgagc gtgcctgagg
     1501 ccgcccggct ggccgacacg tggatcgacg aggcgcacaa caccctttgc ccaacacttg
     1561 ccctggattg accgttcggc ggcgccgcac cttctgactg gccagctatc agctgcatac
     1621 caacttcgac tcagatctgc gacattccct cgtcccgccc ttgtcggccc gtgcaatcgc
     1681 ctgtgtactc ggtgaggtca gggctcatcg aatgcccgga gatcggccgc gatgaggtct
     1741 gcgacaacgc attccgggga gaggaggcag tgcttccatg cgaatagttg gttgggcagc
     1801 gacggtcgct gtcctggccg ccttgaatcc gctggcgcca ccggcaaaag cggaaccgac
     1861 ctgtggggtc aacctcaatg ccccagagat ccaggcagcg atcaagtcat tgccaaccct
     1921 gccgcagagc tacccgtggg acaccaatcc gcgcagcttc gatccgagta gcaactacaa
     1981 cccgtgttcc acactgtcgg cggtcatcat cagcgttgaa ggcgcgacgg gcagctcacc
     2041 ggacctcgtt ctgctttttc acaacggcac ctccgccggt attgccacca caaaggcgta
     2101 ctcgtttacg acgctgaacg cggcgaagac aaccgatgac acggtggccc tcgactacaa
     2161 agacggcaga gacgtctgca cggcgtgccc cggaccgatc acgacggtga ggtacgagtg
     2221 gaagggcgac cacgtcgcga tgttggaccc ggcgccggct tggtgaccca cgcctgtcgt
     2281 cagtcctggg ttcgggcgcc ggtcagcgac tggatggtct gtatttcgct ctcccggtag
     2341 ggccgtccgt cgggttgcag aagatcgctg aaccatacct tcgggggctt ggtgtacgga
     2401 tgatcccagg aatcccacgg taggtaggtc tgagtcttac cggcgaccaa accccaattg
     2461 aaggcgccga cgttgcgacg cttggcgatt ggtagcaccc cctccacact gctgccctgg
     2521 gagcgcgcca ggtactcggt gcagatgatc ggccgcccca gcggcgcaag ttcgtcgata
     2581 cgggcctcaa agccggccgg tgccgcgtag ctgtgaaatg tgatgacgtc ggcattgtcg
     2641 agctggatgc tggcgatggt ggagcgcttg cccggatccg accaatttcc ctgccagaca
     2701 ccgcttgtca agggctggct gggatcgacc tcgcgcgccc actgaaacac ctgggggagt
     2761 agctccgcga cccgctccag cttgtccttt ctctccacct ttcggtacac cttcgccgga
     2821 ttgtcgggct cattccacaa gtcccagccc aatacgcggt tgtcgttgcg gaactggttc
     2881 aacactccag tcacgtagcc gtgcagaacg gcctggtagc tggggtcgcc gaggtgttcg
     2941 gcgccggggc tttgcaccca acccgagttg tgcacgccgg gccttggcgc acgctgctga
     3001 cccagcttgg ggaacgggtc ccaacaggag tcgaacaaga cgaaaagagg tttgatgccg
     3061 tggcgcgccg cgatggcgac gaattgtgcc agccgagtct gaaagcccct ttgatccgag
     3121 gcccacagct gatcgtgcag gaagactcgc atgctgttga acccgatcaa ccgggccaag
     3181 cccagctctc tgtcgatgcg ccgcggatcg taggtggcgg gctgaaacat ctcgagctga
     3241 ttgatggcgt tggcggtgat gtagttggcg ccgacgatcc agccttgggt ctggtaccag
     3301 gtgttggcgc gctcagccga ccaacggcct gccacagcgg tggcgcgggg gggctgggcc
     3361 agcgcggcgc cggccgccag cagcagcggc agtttgagag ccgttcgacg ttgcaccaag
     3421 tgacgataat ttcgcgggcg atctgtccgg tcttgcgcgc tgacgtgtct aggcatgctt
     3481 atcgattcgc aacaacctgg gattgcaaat tgttatctcc tgaacaccat ccaggctacc
     3541 cggccggcgg ggtgaagtct cggcgcaacg ccgtggattg tcttgtgcca caccggccga
     3601 gcgcactgtg taggatggct tgagcgtctt gtcgaagacg tctcgggaga ctctgtggtg
     3661 ccgcgcgtct gcgcgctcag tttggcgcgg ctaccgcgtc gccgaagccg ggcccggctt
     3721 cgggtgtgac attgcgtgcg gtgatctctt cgccgcagtg ggcgcagatc aggcgcggct
     3781 cgacgaactg gccgcaatgg tgacgcaaca caatcggtgg gccgtcgggg ttcggcaagt
     3841 gcttgtcgcc ccactgcatg aggacgacga tcgcggcgaa cagttcgtgg ccggtgtcgg
     3901 tcagccggta ctcgtggcgc tccggatcct gggagtaagg cacccggtcc agcaggcccg
     3961 cattgacgag catccgcagc cgcgatgaca gggtggggcg cggaatgttg aggttgcggg
     4021 cgagctggcc gaagcgctgc acgccgaaga acgcctcgcg caggatcaat agggtccagc
     4081 gctcgccgac cagctcgagg gcacggccaa ccgactcccc ttcgaagcgg tgggacagat
     4141 cggcggcgcc catggttcaa caactgtacc cggttcaatt tctgaaccat ggtggtaact
     4201 tgacggaacc gccgtcatta ccaggagtcc tgatgaatca gccggacctg agcgccgcac
     4261 cactgcgcag agcagatagc gagatggaga acctcgccga gaagatcgcc ctgacggcgc
     4321 gggagatgtc ggcggagatc gaccgcgatc gcagactgcc cgacgaattg gtggcgcggc
     4381 ttggcgaggc aggattgctg cgcgccacga tgccgcgcga ggtacaggcg gcagagctgg
     4441 cccccggacc ggcgctgcgg tgtgccgaag cggtggcgcg cggcgatgct tcagcgggat
     4501 ggtgcgtgtc gatcgcgatc accagcgcgt tgttggtcgc ctatctaccg gcgtccagtc
     4561 gcgacgaaat gttcggtgcc gggcgaagtg tcgccgcggg tgtgtgggca ccgcgaggta
     4621 aggcgaagtc ggtcgacggc ggtgttgtgg tgtccgggcg ctggccgttc tgcagcggga
     4681 tcaaccacgc ggacatgatg ttcgccggtt gcttcgtgga gggccagccg gtgccatcgg
     4741 tggtggcgct acccaaagac gatctgcgcg ccttggacac ctggcacacc ctggggctgc
     4801 gcggtaccgg cagtcacgat tgcgttgccg aggaggtctt cgtccccgcc gatcgagtgt
     4861 tctcggtgtt cgacggtccc agcattgaca ggccgctgta tcgcttcccg gtgttcggct
     4921 tctttgcgct ttcgatcggc gcggcggcgc tgggcaacgc gcgcgccgcg attgacgact
     4981 tggtcgagtt ggccggcgat aagaaagggc tgggggccaa gcgcaccttg gccgaacggt
     5041 cggccaccca aacggcggtc gcgacggccg aggcggcact tggtgcggcg cgcgcactgt
     5101 tttacgaggc gatcgactcg gcctggcaag ccagccacaa tcccgacccg gtgccggtgg
     5161 cgctgcgcaa ccggctacgg ctggcggcca cccacgcggc gcggacctct gccgacgtcg
     5221 tgcgcatcat gtatgacctg gccgggagca gcgcaatcta cgatggctca ccactgcaac
     5281 gccggtttcg cgacgcgttt accgccaccg cccatttcca ggtcaacgag gcatcccgcg
     5341 aactgccggg gcgcgtcttg ctcggccagc actgcgatac ctcgatgctg tgaccgattt
     5401 agaagtcgcc ctaccgtttt ggctggaccg gcccgacgac gaggcgatgg aggtggcgct
     5461 ggcggcgtcg aacgccggtt tcgacgtgct gtgggttggg gaaatggcca cctacgacgc
     5521 gtttgccctt gccaccgcga tagggctggg tgcacccgga atgggcttga agatcggacc
     5581 gctggccgtc gccgttcgcg gcccggtggg gctggcgctg ggcgtcagtt cggtcgcctc
     5641 tctcaccggt agccgggtcg atatcgccct gggcgcctcc agcccggcga tagtggccgg
     5701 ttggcatgat cggccgtggg cacaccacgt gccggtgatg cgggaaacca ttgaatgcct
     5761 gcggtcgata ctgggtgggg cgcgcgtcga ctaccacggg cgccatgtcg ccagccacgg
     5821 ctttcggctg cgcaacccgc agccggaggc tcgaattgca ttgggggcct tcggacctgg
     5881 catgattcgc ctggcggcaa ggcacgccga tgaggtggtg ctcaacctcg catcgccggc
     5941 tcgggtggcg gaggttcgtc acgccatcga ctccgcggcc gccgcagcgg caggtcgcgc
     6001 cgcaccgcgg ctgacggtat gggtgcccgt cgccgttgat cccggtgccg ccgcgcacgc
     6061 tcagctggcg gcgcagctgg cggtctatct cggcccgccc ggctacggcg aaatgttcag
     6121 tgcactgggc tttgaccgcc tcgtcggcgc cgcgcgcgcc ggggcgagcc gtcgagagtt
     6181 ggctgccgcc atccccgtcg aactgcttga gcaggtgggg gcattgggca ccgccgagcg
     6241 agtcgccgcc cggctgcggg actacgaagc ggccggcgcg gactgcctgg cgctggtgcc
     6301 ctgcactgcc gaagatccgg cgggccgggc aacgctgaac gcattgtcga ggaagggtga
     6361 atcgtgacgc tggtcaatac cgtgtgccgg ctggccgcgc gcccgatcgg attgcccaag
     6421 ccatcggact gggaggtcgc cgacgaaccc gttggcggtc cggccgatgg ggagtttttg
     6481 gtgcgcgttg agtatctgtc ggtcgatccg gcgatgcgga cgtggatgaa cgcggggcgg
     6541 tcctacgtgg cgccggtgca gatcggcgag gtgatgcgcg cgggcggcat cgggcgcgtg
     6601 atcgattctc gccacccgga tttcgcggcc ggcgacgagg tgtacggaat gttcggggtg
     6661 cagcgttacg cgcattccga cggtagcggt gtgacgcgcg tggacaccac cctcgcgccg
     6721 gccccggtgc atctgggcgc cctgggcatc agcggtataa cggcctactt cgggctcctc
     6781 gacgtcggtc gcccgcaacc cggtcagacc gtcgtcgtct ccggagccgc cggttcggtg
     6841 ggcagcatcg tcggacaggt agcccggatt gtgggttgcc gggcgatcgg catcgccggc
     6901 ggtgagcaga aatgtcgttg gctggtagaa gagcttggct tcgacgccgc catcgactac
     6961 caagccgggg atctgcgccg tcagctgaag atgcatgccc ccaatggcat tgacgtcttt
     7021 ttcgacaacg tcgggggaga ggtgctcgag gcggggttgt cacgtctggc ccgcggagcg
     7081 cgtgtcgtaa tttgcggagc catctcccag tacaacgccg ccggggagct gcacgggccg
     7141 gccaactaca tgcagttgct ggtcgcacgc gcctcgatga ccgggttcgt ggtcttcgac
     7201 tacgcggatc gatatggcga agccgttggg cagctggcga attggctggc tagcggtgag
     7261 ctgcgcgccc gcgagcaggt ggttgcgggc gatgtcggcg actttcctga ggtgctgttg
     7321 gcgctgtttc ggggtgagaa caccggcaaa ctcgtgctcg cgctgcgcta gcgattcgga
     7381 cggatcggac cgtcacgata gcggccattc atggactggg gccccgctgc gcgcgtgctc
     7441 gacgtatcgc cgggtcatct cgtgcagcgc cgagatgcgt tccagtccgc gttcttcgag
     7501 gtggcgcacc gtttccgtct gccaggccgc gccggtgcgg ccgctgcgaa cccgcgcttc
     7561 gatgacaccg aggtaccggt cgcggtcgtg ggcgtccacg ccccacgcgt cgagtccgga
     7621 cgcggcggcc ggcagcagga cgtcgcgggt gagctgtgct gcgggctggt cggtgccctg
     7681 ccaactcaat tgcgccgcca gcccgtcgcg tgcagcgcgg tgcaggtctc gctcggccac
     7741 cgcgaaaggg gtctgttccc acggagtgcg gtcactgtca gcgattgcgc gcaccagtcc
     7801 gtagtagaag gcggcattgg cgaccatgtc gactgcggtg ggcccgctgg gcagcacccg
     7861 gttctcgatt cgcagctgcg ggctgccgcc ctggacgtcg taaacggggc ggttccactg
     7921 ccacaccgtg ccgttgtgca gccgaagctc atggagcacc ggagcttgcc ctgcctcgag
     7981 ggcagcgtcg ggatcttctg cctccagggt tgggaacagg ggcgggtact cgcgcaccag
     8041 gtggtcgaag aggtccacgg ggtcgctgat ccacccctcc ccgagccgga cgcgcgccgg
     8101 tgcgctggcc ttgacctcgc tggggcggcg ggagtcgagt agctgctcca ccagcgtgat
     8161 tcgggtctcc tgccaggcgt gccggccgag caggaacggg gaattggcgg ccaccgcgac
     8221 ctgcgctccg gcgatcagtt gggccgcgtt gaaataggcc gcaaatcggt cccggtgcgc
     8281 ccgcaagtgc agctgcaggc tggttgcgga ggcttcgggc gcgaccgagt cggtggtgaa
     8341 ttcgaccggc tcgggtgcgt cgctgatgtg cacccggaac ggccggtggc gagcggtgcg
     8401 gatgcggcgg ctcagcagct cgtagcgcgg gttggtggag agccgttcgg cggtcatgtg
     8461 gtcggcgctc agggtgggaa gcatgccaac cgcgatcagg cgggtgccca ggctttcgat
     8521 ccgcgcgccg gacccgtcga gcacgtcggc aagaagttgt tcgctgtccc ggagcacgtg
     8581 gcccgttagc gggtggggcg gcaggttcaa ctcgacattg aactggccaa gctcgtgctg
     8641 catatcggtt cggtccaagg cctgtagaac cgcgtcgttg accagtcgcg gccggcccag
     8701 cgggtccacc aggtcgagtt ccacctccat gccgatggtg tcctcgtggc cggcaaacca
     8761 gccggcctcg accatttgcc gcaacaccgc gactgaacgc gtgagccggc gccggacgtc
     8821 atctccgtgc ccgagaacca acgcggacgc gtcgatgcga tcacccacgg gcctaccttc
     8881 cctcccgcac acccggccat cagttgcttg tgccggtata cctaattcgc aaactaggcg
     8941 tcatcgcggg gtttggcgac tcggaccccg gattgggtgt gggcgcccac ggaaggccag
     9001 cacatacgcc actcccgctc ggtgattccg ccgagcgccg tgcggtcggg ttcttcggtg
     9061 gcatcgggcg cgcggcgcct cgcggcgatc gtgtcctcgg cacggcgcac cgagtccatg
     9121 aactccagga ccgccgcccg cagctcgcct tccgcatcga tgtcaggtga caccacgacg
     9181 gaggtgagcg tcgccgggac caggtccatc ggcaggccag ccctgactgc gcgttcgatc
     9241 accttctggg ccagagccaa cgcgggctga ccatgaaaca ggtcgtgcat caccgagccc
     9301 gcccgtttgt ctgccttttt gcccttctcc cactgcgcca cctgctcctg gaatgagggc
     9361 gaattgcccg ccagcactcc gcggcgccgg ttgcccagct tgcgtatcag ggtgtcggcc
     9421 acgtcatcga tggtgaaggg tcgtcgcggc gcgtcctgcg cgatccgagc ctggaaaagt
     9481 acctgcagga gcaaggcgcc gagttcttcg cgtagctggc cggcatctgc gctacgcagc
     9541 gcatccagca gcgcataggt ttggctcagc aaatagcggc taaccgagac gtgggtctgc
     9601 gcggcttccc acgacccagc tgtgcgtagt tcgtccactg ccgcaacggc atcgatcagg
     9661 cgctcaccgc actgtgggtg cggtatggag atcagccggt caccggcgac caaccgtgcc
     9721 gtaaccgcag gatgtgttgg atcggaggac aacaacacgg tggcgtggct tccggcgcgc
     9781 acggggcgcg ccgcgggcag cagccgagtc aacgcggccg gtatttcctc ggtgtactgc
     9841 acctgctgcc gcagcacttc gagggcttcc attggtacca gcaaataatg cgggtcaatc
     9901 agtacgacag tcatcacaca gccggctccg cgttcgacgg tgacatggca gccgtcgcgg
     9961 ccattgcagt tggcgctgat tcaacccgcg tcggggagcc tcatgatgcc cgccgccagg
    10021 cgcccaacac cgcttcgatg atggccgtgc ggtgggccgc ggtggacacc gtggcatcga
    10081 gccaacgcac cctgcggtct cgccgaaacc acgaccgctg ccgtcggaca tagcgacgag
    10141 tggccagaca ggtttgttgg cgcgcactgt ccagggcctg agtgtctgcg ccggccttga
    10201 gcgcctccat gacttgggcg taccccaacg cgcgtgaagc ggtgaccccc ctggccaggc
    10261 cgcaggggag cagcgagatc acctcttcga tcagacctcg atcgaacatg gctttggttc
    10321 gtgccgctag tcgttcatca agaacctttg tctcgcaatc taatccgatg attgcgctat
    10381 cccagcgagg gctgccgata cgtggggcgg aggcggcata cgggcgaccg gtgatttcga
    10441 ccacttccag cgcacgcacc gtacggcggg cgtcgttgag cgggatgacc gcggccgcgg
    10501 cagggtcgcg gcggaccagc tcggcatgca acctggccgg cccgacctga gcgagacgtc
    10561 gctcccagcg ggctcggatc gctgggtctt tcgccggaaa ggcccagtca tcgagcagcg
    10621 actggacgta gagcatcgag cccccgacca gcagcggcag cgctccgcgt gaggcgatcg
    10681 cttcgatgtc agcggcagcc gaacgctggt agcccgcgac agtggcggtt tcggtgacgt
    10741 cgagcacgtc gagttggtga tgcggtatgc cgcggcgctg ggccagcggc accttgccgg
    10801 tgccgatatc catgccgcgg tagagctggt acgcgtcggc gttcacgatc tccacggcga
    10861 tcttgccgct gagtcggtcc gcaatctcga tcgctaagtc tgacttgccg gttcccgttg
    10921 gtccgatgat cgttagtggt ctcatatcct ctgcctgcta tctcgcctca acagcgcctg
    10981 tcggagggtc agcagtgggg cgaatcgatg tcggcatgcg tgccatcccg tgctcccctg
    11041 cggtggtcct gcttgctagc ggtgacacca caagggttgc gttcggcggc cgcgctggga
    11101 tcagtcaaat ggcctaataa tgcgcatggg tccgctctga gacgctggcc tccccagacg
    11161 acgcgaacgc cgaccgagtt gatgggcaga ggttgctgaa tgcgctgtcg acgtcggtcg
    11221 tgacgatgag ccgatcgatc gcggcggtgc gcacgaagcc ttgctgccgc agttcttcga
    11281 gccagtcgag cagtccgcgg tagtgtccgg cggggtccag caggactacg ggcttgtgat
    11341 gtatgccgag gctggccgcg gtccagcatt cgagcagctc ttcgagggtg cccagaccgc
    11401 cgggcagcgt caggaacccg tcagcgcgtt cgcccatgag gtgtttgcgt tgggtgagtg
    11461 tgtcggtgac gatcagctca tcggcaccta ggtcagcaag ttcggattgc aggagcattc
    11521 tcgggattac gcctgtggtg tgggctccgg cggttctggc cgcgcgggcc accgcgccca
    11581 tcatggcgat ggtgccgcct ccggagatca atcgccatcc gcgtctaccg atttcggtgc
    11641 ccacggcggc ggccaggctc aggtcggcgg ggttgtcgcc gccggaagcg cagtagacgc
    11701 aaatcgtcgg acggccatcg gtccgagcgc gccaggcagg tctgggccca gccgcaacga
    11761 atcccgcctc ctcgagcaat ccggtcaccc gcgcggattc gtcggcgtcc agcagggagc
    11821 cgccgctgtg caggtcgtag attcggctgg ccgtgcgttg tgccggcagg tctcgagtca
    11881 cagaccgtcc tccagtacct tcctcgaact gatcagaagt tgtccgctga cgcgggtcaa
    11941 cttgtcgtgg atcacgcaac tttgggcgat cgccggcttg gtaccgggac gagtgttgat
    12001 ttcgatcaga taggcagatg cctcgatcac gccggcacta cgcgacgcca agtcgatcat
    12061 cgacaaccag tgccgtcgtt gaatcgcatc cccagctctg ctgtcccact tcagcagggc
    12121 tttctcgatt gctgcgcgtg tcgagaccgg gccggcaccg gggatgtgct cgaacgtggc
    12181 gtccttggtg aacgtctttg cgtgggagcc gatgtcgcgc aggtccagta gcctcatctg
    12241 ccgtgcgtaa aactgctgca cctccgcgta caggcagctg tgcagcgcct tgccccgcgg
    12301 ccaggagaac aagcgcaagc ggttcgctga cgggatcacg ccgccgtcac tgccttcagg
    12361 tgcaacagcg cgggcaacac gatgttggtg tggcggtgca gttgggtcct ctcggtcaat
    12421 ttcagccgtg gtagccgacg catcagagtt cccactgcga tctggcattc gaggcgggcc
    12481 aagcgtgccc caaggcagta atgaattcca gcgccgaaca tgaccgctgc gcctcgggca
    12541 cgggtgatgt cgaatcggtc cggctcctcg aacaccttcg gatcccggtt ggctgcgcct
    12601 acgaaggcga tcaccggttg ccccgcacga atgtgcgcgc cgccgagcgt gacgtcttcg
    12661 atgggcttgc gtgccgccgt ggactgaacc gagccgttga aacgcaaact ctcgttgacc
    12721 gcagctgcca tcagctccgg atgcgcccgc agcaatgcca gctggtcagg gcgcgtccac
    12781 agatccgcga tcatgttgcc gatctgcgca accgtcgtcc cgtgtgcggc gaacatgagc
    12841 tgcacacaaa gggccagcag ttcttcgtgc gtcagctgac cggcctcgcg ggccgcgatc
    12901 agggcgctga tcagccccgg ccgtaaccga tcgtggctgg ccgcggcggt ctcgaagaac
    12961 cacaacatgt tcgcggcggc atcgtcggct ctcgctatgg ccgcaggttc cttgcgcaga
    13021 tcgaacccat cgccaaaccg agagacccac accggaaggt ccggatgcaa ctcgtcggcg
    13081 gtcaagccca gcatcgctgc tatcaacgtc attgacagag gaacggcata gttgtcgatc
    13141 acgtcgaacg cagtcgcctc gtcgagcccg tcgatcagcc gatccgcggc cttggccgcg
    13201 atcatccggt aagactcgat tgccgaaggt gtgaacgtgg gcgccacgat ggaacgcaga
    13261 cgcccatgat ggggcggatc cagtgacagc aacagccgac ccgacaattc ggcgaaaccg
    13321 cggggcgcgc caaacactcg cccggatgcc agaggatcgg ccggaaccaa tttgcggcga
    13381 aaccgagggt ccctcagcat cgcaacgaca tgatcgtgtc gaaacaggta ccagcatccg
    13441 ttgtcgccgg gtttgaacgg ttgtccccaa tgcaccggat ccgcctgacg ataggtcgcg
    13501 tacaccgcgt acggatcgtc gcgcagctgc tgatcgtgtg ggtcgaaacg ggccaacatg
    13561 gtgtctgtca cattccgtag ggcggggccg gttgcctacg cgatggcgtt gatcccagcc
    13621 gggatggaca gtcgtgatcg gtcacggttc gcctggcgtc ttgaacgaaa acaactcgta
    13681 tgtcatcagc cgctgcgcaa atgccgaatg catcaactct tcggtgccgg tcacgtgcgc
    13741 cgaccccagc cgtgtcttcc agtatgggac ggtgagtccg gtcaaatcca cctgccgaca
    13801 agtgatcaac ccggcctcgt ctgccgctcg ccggtagtcg gccggctcgt gaatgttcgt
    13861 gcagtattgg tcatcgacgc gctgcttgac gctttcggcg gcccgacccc ggcccgcgca
    13921 ccacgcgatc actacgattt gcccacccgc gaccagcact cggccaaacg tggtgaacat
    13981 caaccccaga tcatcgacgt gctcagtgct ttcgcacgcc cacacggctt gatagcggtg
    14041 tcggatctgg ccggaaccca agcggcggtc aacctcgagc atgtcgccga ccctgaacct
    14101 gacctggtct tccacgccgc gcaccagggc cgttgcggcg gcgaaccgcg cctgctcagg
    14161 cgacactgtc acgccttcca cggcacaccc gaatcgctgg tgaatcatga tcgcgccgcc
    14221 cccggcccca cagccggcat ctagcacggt gccatccgaa ggcggtttac cgaggaactt
    14281 caggccaaag ctgaccagct cggcctcgga gcggtgcaac cagtccagtc gagccttctc
    14341 ctgcatcggc gccggaccgt ccggcaggtc gatgccgttg tgattgaaaa acaatccatc
    14401 acgcgacgcg agcattgcgt tgagcccgtc gcaatcgcgg gtcttccggt cgtagagcgc
    14461 ggcaatggac gtccgccgcg cttcactcaa gccggttact atctcaccag tactcaagtc
    14521 gatcaccctc cctcacttga aaaagccaat cgcccactgc tgttggctgc gcaaggactt
    14581 cgatgcggca gtgactttgc acagtcgccg tccgtggttg tccaccgctg cggccgcacg
    14641 ggtagcgggg gagaaagcgg cgtaggtgcg gtaaaggcca ggagcttcat cggtgggccc
    14701 ccgccgctaa cggcacgcgg tgtcgggatg cgtaccggaa ctggggattt gggcttgggc
    14761 aaccgtgatt cggggtaccc ccagcccgac gccacgcgtt gtcggggtct ggccgcgttc
    14821 gctggcatca cctgcggggg tcctgcgatg ctgcagcagc ggcccgtctg cgatcagatg
    14881 gtgcggtgct gcatcggtga tttcgacatc caccaagtca cccggccgga ccgaaccgtc
    14941 ggcgctgtcc ggacggaagt ggacgagtcg gccgtcgcgg gcccgcccgc tgattcgcgc
    15001 tgtggtggcg tttttgcggc cctctcctgc gaccaccagc agttcctgcc gggtcccgac
    15061 cagggatcgg ttgctctcca aggagattcg ctcttgcagc gccaccagcc gctcgaagcg
    15121 ctgctggacg acgttcttgg gaatctggtc gggcatgtcc gccgcgggtg tgcccggccg
    15181 aggcgagtat tggaaggtga atgcgcttgt gaaccgcgct ttttgcacca cgtcgagggt
    15241 ctgctcgaag tcatgttcgg tttcgccggg aaagccgacg atgatgtcgg tggtaatggc
    15301 cgcgtgcggt atcgcggcac ggaccttgtc gatgatgccc aggtagcgat cgcgccggta
    15361 ggagcggcgc atggccttga ggatctggtc cgaacccgat tgcagcggca tgtgtagatg
    15421 cgggcacaca gccggagttt cggccatcgc caggatcacg tcgtcggtga attcggccgg
    15481 gtgcggtgag gtgaaccgga tgcgctctag accctcgatc cggccgcaag cgcgtagcag
    15541 ctgcgcaaac gcacctcgat ccctaggcag tggttcctcg cccgtcgaag ggtccgggtc
    15601 tgcgaaattg acgccgtagg agttgacgtt ttggccgagc agggttactt ccagcacgcc
    15661 ctgctctacc agggcctgca cctcggcgag gatgtcgccg gggcggcggt cggcttcctt
    15721 gccgcgtagc gacgggacga tgcagaaggt gcagctgttg ttgcagccca ccgagatcga
    15781 cacccacgcg gcataggctg aatcccgtgc cgcgggcagc gccgaaggga atgtccgcag
    15841 tgattcgaga atctcgactt gcgcgtcttg gttgtgccga gagcgttcca agagcaccgg
    15901 cagtgagccg atgttgtgtg tgccgaagac gacgtcaacc catggtgccc ggtcgagcac
    15961 gatgtggcgg tctttttggg ccaggcatcc gccgaccgcg atttgcatgc cgggccggct
    16021 cgccttgatc ggagccaggt gcgctagcga gccgtagagc ttgttgtcgg cgttttcacg
    16081 caccgcgcag gtgttgaata ccaccaggtc tgcaggcgcg cccgggtcgg ctttgatgta
    16141 cccggcgtct tcaagcaaac ccgccatgcg ctcggagtcg tgagcgttca tcaagcagcc
    16201 gagagtgcgg acttcatacg tgcgggcggt tgcgttgccc gcggtatcat tcctggtcgc
    16261 aggtggccgc tcagtcacaa tgtggtcttg agtcacgatt cctccggcaa tttctcgact
    16321 ggaggggcga aatttccatc gcacgcccaa aaggatcgga acaaggcata gccgaaattg
    16381 gactaatcga attccccagg aaaggggaat tcgacaagcc acggcgagat atagcccatg
    16441 caaaactttc cgagcctcct tttgagggag gtgcgagctt tgctgagtcc gggccccctt
    16501 ttgagggggg tgcggggttc ccgggcctcc ttttgagggg ggtgcgggtt ttgctgagtc
    16561 cgggccccct tttgaggggg gtgcggggtt cccgggcctc cttttgaggg gggtgcgggt
    16621 tttgctgagt ccgggcctcc ttttgagggg ggtgcggggt tcccgggcct ccttttgagg
    16681 ggggtgcggg ttttgctgag tccgggcccc cttttgaggg gggtgcgggg ttcccgggcc
    16741 tccttttgag gggggtgcgg gttttgctga gtccgggccc ccttttgagg ggggtgcggg
    16801 gttcccgggc ctccttttga ggggggtgcg ggtttgctga gtccgggact ccttttaagg
    16861 gagctgcgga tccacttcga tttgaatctc tgagaagtgg tgctggtaag tactgtaaac
    16921 cccatcacct atgccgcaca agtcccgtgt ggcgattcct cgaaaaattt cccggtaagc
    16981 agataaaagc cccgcgagag gcatggtagg tgcggcgttg ggccatttcg cgccgcactt
    17041 tggggccgca ctcgccggtc agaggggtcg attgcccgca ccgacgactt cggcaacaag
    17101 cggtaacctc ggtcgccatg ggggagagcc gatgagcgca ggcctgttcg ggctgctcga
    17161 tgacgtcgct gccctggcgc ggctggccgc ggcctcggtg gacgacgtcg gttcggccgc
    17221 ggctcgcgcg accgccaagg cggcaggcgt agtggtcgat gacaccgcgg taacgccaca
    17281 attcgtgcac ggcatcaccg ccgagcgcga actgccgatc atcaaacgca ttgcgctcgg
    17341 ctcgctgcgc aacaagttgg tgttcatcct tcccggcgcg atgctgctta gccagttcgt
    17401 cccgtggctg ttgagtccaa tcctgatgct cggcgccaca tacctgtgtt acgaaggcgc
    17461 ggagaagctg tggagtgcgc tgcgcggcaa cggttcccag gccaggaggc cgaaagacga
    17521 acagcaagtg gtgaccgggg cgatccggac cgacgtcatc ctctccgccg agatcatggt
    17581 gatcgcgctc agcgaagtgg ccgacttggc ttttctgcca aggcttgtcg tcctgatcgt
    17641 cgttgcgctg gtgatcactg gcgcggtgta tggggtggtg gcggcgatcg tcaagatgga
    17701 cgatgttggg ctgcggctgg ccgagacgtc gtctcgggtc gggcagcggc tcggtcgcgc
    17761 cctggtcgct gggacgccca ggttgttgtc catgatcgcg gcggtcggaa cggttgcgat
    17821 gctgtgggtg ggtggccaca tcctgttggt gggcagcgat cagatcggtt ggcacacccc
    17881 atacggcttg gtgcatcatc tcgatgaaca ggtgcgccac gcggtcgggt ccctaggtac
    17941 cgtcgtggcc tggctggtca ataccggcgt gtcggcggcg ctcggactga ttgtcggggc
    18001 agtagcggtc acgctcgtgc acctgctgcc gtttcgtcgg gtgggttagg cgccggcgtg
    18061 cgccgtcaaa tgaagtccga gccgccgtcg gcattcaccg tcgcgccggt cacatagccg
    18121 ttgcgccgcg acaccaggta ggcggtgatg gaagcgacct cctcgggaag gccggcgcgg
    18181 cccagatcgc acggctggtg aaagtatttg tcaatccagg ccatgacgtc gtacgggttg
    18241 gtggcatcga gtccgtcggc ggccagcagg tctttgagct gttcggtaaa gctggccgtg
    18301 acgatggttc ccgggcacac gcagttcacc aggatgccct ccttggccag gctcttcgac
    18361 aggttcttgg tcacgctgga cagggccgcc ttcgaggccg tgtaggcgac caggcgtggg
    18421 ttctgtcgct gaatcgagtg cgcggacagc gtcacaacgc gggcccagtc cgcggcgcgc
    18481 agcaagggca acgcggcgcg aatcgcccgg acccccgaca tcgtgcccag cgtgaacgcg
    18541 gcatcccaag cggcgtcgtc gagttcctcg aagtacccgt cgcccggtcc gatcgtgtgc
    18601 accaggcaat tgagttgccc ccagcgttcg gagacggcgg cgaaggcgct ggtgatcgat
    18661 gcggcgtcgg ccatgtccgc gctgatcgcc accgcgtcgg gagcgccggc ctgacttagc
    18721 ctttccacgg cgctgtccag tgcccgcttg ccacgggcga tcaccgccac gctggctcct
    18781 tcggcggcca gggtttcggc gatggccagg cccatgcctt tgctgcctcc ggtgacgacg
    18841 gccttggaac cgctgaagcc caggtccatc gcatctcctc tgcgggcggg cgcctcacat
    18901 gtcagtctgg cgcggtgatc tgcgcaatag tgtccggcgc aacgcccagt ccgcgcaggc
    18961 aaaatcgcac cgtgctctcg cgaacctcgt cgcgtcggca atccccggag gcccactgct
    19021 gttccgtgtt ggcccacacc acgccctgaa tggagcgcgc ctcgctgtgc gggtcgacgt
    19081 cgtggaacac ttcctgggcc acgccgaggt gaagctgctc gatgagcggc tcaagcgttt
    19141 cggcgtatgc gggttcgacc agctcggggg tgttgagcag atgtgattga gcatccatgg
    19201 acaggtgacg caggtccgcc ttgaccgcgt cgtcgaaagc caagtcgagg cggccgtcga
    19261 tccaggcagc cactccttcg atcggatttg tcgctttggc catgagcgtt ctgagccgca
    19321 ccgcttcgac ccgggcgacc tcgaggaaca ccgcggctac cagttggtct ttcgactcga
    19381 aatgccggta gaacgcccgg gtgctgagtt gggcccggtc caggacggtc gcgacgctaa
    19441 gtccacgaac cccatgttcg cgaaccgaca tcgacgcggc gaccaggatg gcgcgccgaa
    19501 tgccaggatc cggagcaagc ttgtgccggc gccgcgtaag ccggctactc aggtccgcct
    19561 ggcggcgggt gcccgggttg ttcggatgcg tcatagatcc gtaggtaccc accaggcgct
    19621 tccgggacac ccgcagccga catttcatcg tcgctgcaat gtcggacatg tgttagctac
    19681 ctgcgcggca gtgcattgtg ggtgaggggg atgagccgcc ttttacgggc aatatgtgcg
    19741 catcgagatg tcgacgtagt cgccagcgtg gttgctgagg gccggattgc tcgaacgaaa
    19801 tgccgcgacg atctcgtcca cagtgagccc acgacggaag ttctcgcaca ccaacttgcc
    19861 gttgtagatc gctgcgttgg gattggcgaa ggagataccc cggtcgttga gcgctgcgat
    19921 gtaggcgctg tcctgctcag gagttgaggc gatcgtcgtc gtggtggttg gggcggacgt
    19981 cggcgttggc gcaatctggg tgaccgaccg cggcttcgag gccttgcccg gcgagctctc
    20041 cgtggacagg gcccagccac cgatcacgat caccgccgca aacccgagac cgagcaacag
    20101 tagggccgcg gccctggcca aggtggtgcg ccaggactgg acgagcgacg ccggttcagc
    20161 agcaagctcc tcgccgcgac catcggggat gtccgggaca tcggggaggt ctgggccggg
    20221 gtcgcggacg tcgctgacgt cctgttcgcg cgaccaggcc gtctcgaccg tgtcggtggg
    20281 tgcgggactg gggacggctg ccgtcttgtc gccgtcgagt gcggcggtct tgtcggaagc
    20341 cgggaccggc tcggccatga gggccatggt agccatcgac tccgtcaccc gatgcgggcc
    20401 aacggcgggc gcccgtttta tgtgaggtga cggtcgcgcc acctggcgaa tcggcccgtc
    20461 ggtgcgtgta tcgccgccat caccgagctc atcgatgaag ccaccgaact cgcgtgctcg
    20521 gcgggctcgg cgaccggcgg tccatcaccc tcccaccacg tcggccgcaa tagtgccgtc
    20581 gtcaccggaa tcgcgtcctc gacgctgctg cggccccact cgtaggcacg gtcgatggcg
    20641 ccggccgagg gggccaggtt gatcggtgac agcgtcggct ggaacctgac caggtggtcg
    20701 gcatacggca aattgcgcac catctggagc tggatcgcct gggtaatcgg ggccagccac
    20761 atgtgccggg agtcccactg cggatggaag caatcaaagg ccaggtagca cgcgttgcgg
    20821 gtgccgagct ttccgtcacg cacccgcttc cacgccaatt cgaccggcac gttgctggcc
    20881 gcgccgccgt cgacgatcgc cgcgatgtct tggtcggcgc agagggcatc gagcatgtcg
    20941 agcatgcggt catcactggt ttcgtggtgc agcacgccgg gaacggcaga cgaaaacgac
    21001 gccgcgtcga cgacgtcgaa gtcgcgatcg gggtcatcgc cgctgaccac gatcggtttg
    21061 accacccgca agtcgatgaa ggcggaaacc tgccacattc gggctgcgac cagcgggccg
    21121 atgccgatgg gctggaaggg cagtgagcgc agttgcagcg ccgccagttc cggacggcga
    21181 aaccgggatg gcagtgcgga atacggttgc tttcgcacgc cggagaccac gacatcgaac
    21241 ggaatcgtca gatctgacat gcggagccgg atgttgtctt cacggctgag cagcgatagc
    21301 gcgaattggt cgaagcgcag ggcgaacatc ccggccaagc cgtggcggcg gcgcaaccgc
    21361 tcggggccca gaatggcgcg ataagacacc gtcttggccc attccacata gtcgtcgatc
    21421 ggcaccggca ggcaacgcgc caccagactg ccgatgatcg acccgaacga cgacccgatc
    21481 atgtagtcag gcgtttggcc ggcctccagg aggcgctgga tgccgccgat gtagacgaac
    21541 cccgcgccgc ccccgccgcc gaggatggtg acgagcttct tgtagccgac ttcggagtcc
    21601 agttcggccg cagagaagtc gctgccgtgg cgttcgatca gcactcgccg ttggtcgtct
    21661 tggtcggcgg acaaaccgtc gagcgcggtg cgtgcggcct tgag
//
