LOCUS       NC_009636              20915 bp    DNA     circular CON 15-MAR-2024
DEFINITION  Sinorhizobium medicae WSM419, complete sequence.
ACCESSION   NC_009636
VERSION     NC_009636.1
KEYWORDS    RefSeq.
SOURCE      Sinorhizobium medicae WSM419 (Ensifer medicae WSM419)
  ORGANISM  Sinorhizobium medicae WSM419
            Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
            Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
REFERENCE   1  (bases 1 to 3781904)
  AUTHORS   Reeve,W., Chain,P., O'Hara,G., Ardley,J., Nandesena,K., Brau,L.,
            Tiwari,R., Malfatti,S., Kiss,H., Lapidus,A., Copeland,A., Nolan,M.,
            Land,M., Hauser,L., Chang,Y.J., Ivanova,N., Mavromatis,K.,
            Markowitz,V., Kyrpides,N., Gollagher,M., Yates,R., Dilworth,M. and
            Howieson,J.
  TITLE     Complete genome sequence of the Medicago microsymbiont Ensifer
            (Sinorhizobium) medicae strain WSM419
  JOURNAL   Stand Genomic Sci 2 (1), 77-86 (2010)
   PUBMED   21304680
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3781904)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Glavina del Rio,T.,
            Dalin,E., Tice,H., Pitluck,S., Chain,P., Malfatti,S., Shin,M.,
            Vergez,L., Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N.,
            Mikhailova,N., Reeve,W. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Complete sequence of Sinorhizobium medicae WSM419 chromosome
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3781904)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Glavina del Rio,T.,
            Dalin,E., Tice,H., Pitluck,S., Chain,P., Malfatti,S., Shin,M.,
            Vergez,L., Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N.,
            Mikhailova,N., Reeve,W. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUN-2007) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000017145.1-RS_2024_03_15
            Annotation Date                   :: 03/15/2024 03:53:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,520
            CDSs (total)                      :: 6,452
            Genes (coding)                    :: 6,144
            CDSs (with protein)               :: 6,144
            Genes (RNA)                       :: 68
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 55
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 308
            CDSs (without protein)            :: 308
            Pseudo Genes (ambiguous residues) :: 0 of 308
            Pseudo Genes (frameshifted)       :: 194 of 308
            Pseudo Genes (incomplete)         :: 203 of 308
            Pseudo Genes (internal stop)      :: 37 of 308
            Pseudo Genes (multiple problems)  :: 111 of 308
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:32:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3260605
            Orig. end                         :: 3281520
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000738.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4001622
            Source DNA and bacteria available from Wayne Reeve
            (reeve@murdoch.edu.au)
            Contacts: Wayne Reeve (reeve@murdoch.edu.au)
            Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LLNL
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20915
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="8"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20915
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20915
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10915](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10915
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(112..450)
                     /gene="fdxA"
                     /locus_tag="SMED_RS15625"
                     /old_locus_tag="Smed_3113"
     CDS             complement(112..450)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003535779.1"
                     /locus_tag="SMED_RS15625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3113"
                     /product="ferredoxin FdxA"
                     /protein_id="WP_012067320.1"
                     /transl_table=11
                     /translation="MTYVVTDNCIRCKYTDCVEVCPVDCFYEGENFLVIHPDECIDCGV
                     CEPECPAGAIKPDTEPGLDMWLKLNADFSTQWPNITVKRDPLPEATEMDGLEGKYEKYF
                     SPEPGQGD"
     misc_feature    complement(710..723)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.24"
                     /tool="antismash"
     gene            complement(849..1262)
                     /locus_tag="SMED_RS15630"
                     /old_locus_tag="Smed_3114"
     CDS             complement(849..1262)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018209249.1"
                     /locus_tag="SMED_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3114"
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="WP_012067321.1"
                     /transl_table=11
                     /translation="MEKQPPSAPATRQRLDKWLFFARLIKSRSLAQKAIEAGHVVVNGK
                     RETQSSAQIKAGDMLEVSLERRDLVLRVLLPGSRRGPYEEARLLYEDLTPAAPAGKPTL
                     YEQATRDRGAGRPTKRERRETDRLRPGADHEDD"
     gene            complement(1272..4337)
                     /locus_tag="SMED_RS15635"
                     /old_locus_tag="Smed_3115"
     CDS             complement(1272..4337)
                     /EC_number="3.6.4.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013844928.1"
                     /locus_tag="SMED_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3115"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_028054314.1"
                     /transl_table=11
                     /translation="MILSGRGVTAVLGPTNTGKTHYAIERMVAHDSGVIGLPLRLLARE
                     VYTRLVEKVGHHNVALITGEEKIAPHRARYSVCTVEAMPRETTASFVAIDEVQLAGDLE
                     RGHIFTDRVLHLRGRGETLFLGAATMRPILEYLLPGITVVERPRMSQLLYAGSKKITRL
                     PNRSAIVAFSADEVYAIAELIRRQRGGAAVVLGALSPRTRNAQVALYQEGDVDYLVATD
                     AIGMGLNLDVDHVAFAQDRKFDGYQYRNLNPAELAQVAGRAGRHVRDGTFGVTGRVDPF
                     EEELVHRIESHEFDPVRVLQWRSKALDYSSVKALKKSLEAAPAVSGLARALPAVDQQAL
                     EHLTRYPEIVDVATTSERVEKLWEACALPDYRRITPAQHADLISSIYADLVRHGTVNED
                     FMAEQVRRADHTDGEIDTLSARIAQIRTWTYVSNRPGWLADPTHWQEKTREIEDRLSDA
                     LHERLTKRFVDRRTSVLMKRLRENAMLEAEISVNGDVFVEGHHVGQLAGFRFTLVAGSE
                     GTDAKAVQGAAQKALALEFEARAARLHAAGNGDLALSSDGLVRWLGDPVARLTASDHVM
                     RPRVILLADEQLQANAREHVLARIERFVNHHISTVLKPLDDISRAEDLEGLAKGLAFQL
                     VENLGVLFRRDVAEEVKSLDQESRASIRRYGVRFGAYHIFLPALLKPAPAELITLLWAL
                     KNDGLDKPGYGDLIPMLAAGRTSVVTDPSFERTFYRLAGFRFLGKRAVRIDILERLADL
                     IRPLLQWKPGTSPRPEGAYDGRRFVATTSMLSILGATPDDMEEILKGLGYRADAVTAEE
                     AAAFLASQNGATPADTPAGEAAVSETDAGAQQTGEPAAEAEAARIPPAEAETRDAPAAE
                     AEAADAATSGQEVAPTSDETPAPAEPETPAESKPVLLWRPGTRQDNQRQGGRQGEQRRG
                     GQRHAQTEGREGGRRQGAQGKPPGKPREGKPQEGKGSEGRPGGQRKERGDRYDRSKPSP
                     AKFEGRPPRKEKPIDPDSPFAKLAALKEQMKK"
     misc_feature    4664..4679
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    4823..4836
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    4826..4841
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    4958..4972
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.11"
                     /tool="antismash"
     gene            complement(5108..5833)
                     /locus_tag="SMED_RS15640"
                     /old_locus_tag="Smed_3116"
     CDS             complement(5108..5833)
                     /NRPS_PKS="Domain: PKS_KR (3-167). E-value: 6.5e-18. Score:
                     57.2. Matches aSDomain:
                     nrpspksdomains_SMED_RS15640_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014766331.1"
                     /locus_tag="SMED_RS15640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3116"
                     /product="beta-ketoacyl-ACP reductase"
                     /protein_id="WP_012067323.1"
                     /sec_met_domain="adh_short (E-value: 1.1e-36, bitscore:
                     124.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVALVTGGSRGIGAAIAIALKAAGYKVAANYAGNDEKAQAFKQ
                     ETGIPVYKWDVSSYEACVDGIARVEADLGPVDILVNNAGITRDAMFHKMTPQQWGEVIG
                     TNLTGVFNMTHPIWSGMRDRGFGRIVNISSINGQKGQMGQANYSAAKAGDLGFTKALAQ
                     EGAAKGITVNAICPGYIGTEMVLAVPEKVLNERIIPQIPVGRLGEPEEVARCVVFLVSD
                     DAGFITGSTISANGGQYFA"
     aSDomain        complement(5333..5824)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SMED_RS15640_PKS_KR.1"
                     /evalue="6.50E-18"
                     /label="SMED_RS15640_PKS_KR.1"
                     /locus_tag="SMED_RS15640"
                     /protein_end="167"
                     /protein_start="3"
                     /score="57.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGSRGIGAAIAIALKAAGYKVAANYAGNDEKAQAFKQETG
                     IPVYKWDVSSYEACVDGIARVEADLGPVDILVNNAGITRDAMFHKMTPQQWGEVIGTNL
                     TGVFNMTHPIWSGMRDRGFGRIVNISSINGQKGQMGQANYSAAKAGDLGFTKALAQEGA
                     A"
     CDS_motif       complement(5384..5443)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SMED_RS15640_0001"
                     /evalue="2.40E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="SMED_RS15640"
                     /protein_end="150"
                     /protein_start="130"
                     /score="16.8"
                     /tool="antismash"
                     /translation="NISSINGQKGQMGQANYSAA"
     gene            complement(5948..7129)
                     /locus_tag="SMED_RS15645"
                     /old_locus_tag="Smed_3117"
     CDS             complement(5948..7129)
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010970528.1"
                     /locus_tag="SMED_RS15645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3117"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_012067324.1"
                     /transl_table=11
                     /translation="MSNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGV
                     EAGEVDEVILGQVLPAGEGQNPARQAAMKAGVPQEKTAWGMNQLCGSGLRAVALGMQQI
                     ATGDAKVIVAGGMESMSMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGTTAE
                     NVARKWQLTREEQDEFALASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRH
                     GATLESIAKLRPAFDKEGTVTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWAT
                     AGVDPQIMGTGPIPASRKALEKAGWSVAEIELVEANEAFAAQACAVNKDLGWDPSIVNV
                     NGGAIAIGHPIGASGARVLNTLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL"
     misc_feature    complement(7300..7314)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.88"
                     /tool="antismash"
     gene            7352..7930
                     /gene="phaR"
                     /locus_tag="SMED_RS15650"
                     /old_locus_tag="Smed_3118"
     CDS             7352..7930
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="phaR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003535770.1"
                     /locus_tag="SMED_RS15650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3118"
                     /product="polyhydroxyalkanoate synthesis repressor PhaR"
                     /protein_id="WP_012067325.1"
                     /transl_table=11
                     /translation="MGKNEGQIVIKKYANRRLYNTGTSTYVTLDDLAVMVKRGEDFIVQ
                     DAKSGEDITHSVLTQIIFEQESKTGNTLLPISFLRQLISFYGDQMQMVVPSYLEHSMQA
                     FTEQQAQMREQITKAFGETPIGKNLKVPLQLVEEQVRRNTEMFHQAMQMFSPFMAAPAA
                     KESKKAEAKDIDELKEQLRALQTKLDNLG"
     gene            complement(8012..8197)
                     /gene="rpmF"
                     /locus_tag="SMED_RS15655"
                     /old_locus_tag="Smed_3119"
     CDS             complement(8012..8197)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016556742.1"
                     /locus_tag="SMED_RS15655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3119"
                     /product="50S ribosomal protein L32"
                     /protein_id="WP_012067326.1"
                     /transl_table=11
                     /translation="MAVPKRKTSPSKRGMRRSADALKAPTYIEDKNSGELRRPHHIDLK
                     TGMYRGRQVLTPKESA"
     misc_feature    complement(8250..8265)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            complement(8335..8982)
                     /locus_tag="SMED_RS15660"
                     /old_locus_tag="Smed_3120"
     CDS             complement(8335..8982)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1193: glutathione S-transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014330177.1"
                     /locus_tag="SMED_RS15660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3120"
                     /product="glutathione S-transferase family protein"
                     /protein_id="WP_012067327.1"
                     /sec_met_domain="GST_N_3 (E-value: 3e-14, bitscore: 50.9,
                     seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKLVLYVGNKNYSSWSLRPWLALTASGIPFEEVVIPFDFPAGNP
                     RIREMSPTGRVPVLHHGETRVWESLAIIEYAAELFPEAGLWPDSREDRARARSYSMEML
                     SGFQALRGACPMNIRRSKKAIDLPDGVTEDVARIETIWHEQTARSGGPFLFGRFTAADA
                     MFAPVVIRFEVYDLVKDPATLAYMAAVRGHPAFRKWEEAAKAEPWIVPEDEA"
     gene            complement(9061..9849)
                     /gene="mtgA"
                     /locus_tag="SMED_RS15665"
                     /old_locus_tag="Smed_3121"
     CDS             complement(9061..9849)
                     /EC_number="2.4.1.129"
                     /GO_component="GO:0009274 - peptidoglycan-based cell wall
                     [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="mtgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018013048.1"
                     /locus_tag="SMED_RS15665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3121"
                     /product="monofunctional biosynthetic peptidoglycan
                     transglycosylase"
                     /protein_id="WP_012067328.1"
                     /transl_table=11
                     /translation="MENRADGKEVDGRGVDIISEEREEAELPAGRQTAVRRTWRARRRR
                     LVLLVLSILFLPYALIFFYLAEFIHPVSTLMLRDLVLARGYDRQWVEFDDIAPVLVQSV
                     MMSEDGQFCSHAGVDWAQMRAVVEDALDGGQTRGASTIPMQTAKNLFLWNGRSFVRKAM
                     ELPLAVAADFVWSKRRLMEIYLNVAEWGEGIYGIEAAARHHFGVSAAELSRRQAALLAV
                     SLPNPVDRNAGKPGRGLRRLASVIERRASRSGGYITCLYD"
     misc_feature    complement(9896..9908)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            10001..10915
                     /locus_tag="SMED_RS15670"
                     /old_locus_tag="Smed_3122"
     CDS             10001..10915
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003535760.1"
                     /locus_tag="SMED_RS15670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3122"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_012067329.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.4e-55, bitscore:
                     183.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDERSSFPERLKSNAVAVEALLETLLDPAVRGGEISRPANLLEA
                     MRHAVLNGGKRLRPFLVSETAALLGGDVQAALRIGAALECIHCYSLVHDDLPAMDNDDM
                     RRGKPTVHVAFDEATAILAGDSLLTFSFDIIAAPETALSDRQKTALVLALARAAGHGGM
                     AGGQALDLAAEKSAPDETGIVLLQSMKTGALLRFACEAGAIIADAAAEDRQRLRAFGEK
                     IGLAFQLADDLLDLTADAAHIGKATGKDAARGKGTLVALHGQPWAEQRLESLVAEAEAL
                     LEPYGARSEVLAETARFIANRRN"
     gene            10919..11974
                     /gene="hisC"
                     /locus_tag="SMED_RS15675"
                     /old_locus_tag="Smed_3123"
     CDS             10919..11974
                     /EC_number="2.6.1.9"
                     /GO_function="GO:0004400 - histidinol-phosphate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (24-347). E-value: 3e-59.
                     Score: 192.9. Matches aSDomain:
                     nrpspksdomains_SMED_RS15675_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="hisC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010970532.1"
                     /locus_tag="SMED_RS15675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3123"
                     /product="histidinol-phosphate transaminase"
                     /protein_id="WP_012067330.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.9e-57, bitscore:
                     192.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEA
                     IRAAADMDLRLYPDPVALGLREAIARRYGMSVGEVFVGNGSDEVLAHTFAALLKHDRPL
                     LYPDISYSFYPTYAGLFGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIGLPL
                     SDIERLVSEHSDQPVVVDEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFA
                     IGQRPLIEALERVKDSFNSYPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLE
                     ARGFEVLPSQANFVFARHQNHAGQTLAAKLRERAVIVRRFAKPRIEDFLRITIGTDDEC
                     AKLVAALDEIL"
     aSDomain        10991..11959
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SMED_RS15675_Aminotran_1_2.1"
                     /evalue="3.00E-59"
                     /label="SMED_RS15675_Aminotran_1_2.1"
                     /locus_tag="SMED_RS15675"
                     /protein_end="347"
                     /protein_start="24"
                     /score="192.9"
                     /tool="antismash"
                     /translation="NLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDPVALGLREAI
                     ARRYGMSVGEVFVGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGLFGIEAVEI
                     PLNADFRIEIAGYRRPAGAIILPNPNAPTGIGLPLSDIERLVSEHSDQPVVVDEAYIDF
                     GGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFNSYPLGR
                     AALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQNHAGQ
                     TLAAKLRERAVIVRRFAKPRIEDFLRITIGTDDECAKLVAAL"
     gene            complement(12037..12825)
                     /locus_tag="SMED_RS15680"
                     /old_locus_tag="Smed_3124"
     CDS             complement(12037..12825)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (17-136). E-value: 2.8e-11.
                     Score: 35.6. Matches aSDomain:
                     nrpspksdomains_SMED_RS15680_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020050238.1"
                     /locus_tag="SMED_RS15680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3124"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_012067331.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-31, bitscore:
                     107.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEISLDAPKLFDLAGNVALVTGAGSGIGQRIAIGLAQCGADVGL
                     LDRRTDDGLAKTADLIEKAGRRSIQIAADVTSGAALDEAVARTEAELGPLTLALNAAGI
                     ANAHPAEEMEETQFQTMMDVNLKGVFLSCQAEARAMLRNGRGSIVNIASMSGVIVNRGL
                     NQCHYNASKAGVIHMSKSMAMEWVGRGIRVNTISPGYTATPMNTRPEMVHQTRLFEEQT
                     PMQRMAGVDEMVGPAVFLLSDAASFVTGVDLLVDGGFCCW"
     aSDomain        complement(12418..12774)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SMED_RS15680_PKS_KR.1"
                     /evalue="2.80E-11"
                     /label="SMED_RS15680_PKS_KR.1"
                     /locus_tag="SMED_RS15680"
                     /protein_end="136"
                     /protein_start="17"
                     /score="35.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGAGSGIGQRIAIGLAQCGADVGLLDRRTDDGLAKTADLIE
                     KAGRRSIQIAADVTSGAALDEAVARTEAELGPLTLALNAAGIANAHPAEEMEETQFQTM
                     MDVNLKGVFLSCQAE"
     CDS_motif       complement(12703..12768)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SMED_RS15680_0001"
                     /evalue="6.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="SMED_RS15680"
                     /protein_end="41"
                     /protein_start="19"
                     /score="12.5"
                     /tool="antismash"
                     /translation="LVTGAGSGIGQRIAIGLAQCGA"
     misc_feature    12789..12805
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: strong, score: 25.77"
                     /tool="antismash"
     gene            complement(12842..14329)
                     /locus_tag="SMED_RS15685"
                     /old_locus_tag="Smed_3125"
     CDS             complement(12842..14329)
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003579720.1"
                     /locus_tag="SMED_RS15685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3125"
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_012067332.1"
                     /transl_table=11
                     /translation="MTPHSPILSLRRIRKSYGPIKVLHGIDLDIHPGEVVALLGENGAG
                     KSTLSNIISGTVQPSAGEMTWLGRAYAPADPRAAMEEGIGMIHQELKLLPKLSIAENVF
                     VGRYPMKAGRIDRKTMEDRARSGLHRLGLDISPDRLVDGLSTGKQQLIEIAKALTLNAR
                     LLILDEPTAALGAEETQLLFRQIERLKSEGVGIIYISHRLEEIRKIADRIVVMRDGAKV
                     QEFESGDVPIRTIVEAMVGRSLERMFPTLPAPTDQVTLEVRNLSSPSNAFRDISFSVRR
                     GEVFGIAGLMGAGRTELVRAISGADPISSGEVLLHGRPVTPRSPIDAIRNGIVLVPEDR
                     KLQGVVLDHSIAENIGYANLGEISRSGWVSSRRIRQFAEECIKTFGVKGRGGQNAGELS
                     GGNQQKVVLAKWLARKPQVVVLDEPTRGIDVGARSSIYDLIIDLAREGVAVIVVSSDLE
                     EVLGVSSRILVMAQGKQAGILNREDANDVSVMELATI"
     gene            complement(14356..15288)
                     /locus_tag="SMED_RS15690"
                     /old_locus_tag="Smed_3126"
     CDS             complement(14356..15288)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067333.1"
                     /locus_tag="SMED_RS15690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3126"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_012067333.1"
                     /transl_table=11
                     /translation="MKLSTLLVAATTASVLALPASAAEVKKIGLAVPNLQADFFNQIKL
                     GVEKHAREKGLEVVVVDAKNDTNTQVSQVQDLMIQDIDAFIYIPAGAAAAAVPTRLARE
                     AGIPVINVDRVPEGAPGDTFIAGESVESAYAVCKFIIEKAGGSGKMAIIHGQKGTTPEV
                     DRFTGCKRAIDENKGVELIDQQWSNMWSADEGFSIAQNMLQANPDITIIFGQADGLAMG
                     AAKAVDVANLSDKVIIGGYDGDVSALEYLARCKGPFIATATQSTQKMGVLAVESALAVA
                     AGEKVEERQTPNAVLTTCDNAPEFVKNHP"
     gene            complement(15414..16388)
                     /locus_tag="SMED_RS15695"
                     /old_locus_tag="Smed_3127"
     CDS             complement(15414..16388)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067334.1"
                     /locus_tag="SMED_RS15695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3127"
                     /product="ABC transporter permease"
                     /protein_id="WP_012067334.1"
                     /transl_table=11
                     /translation="MRAAVQDKQGAAVRLLPSLKGATGPLIGLIVLCLFLTFATDKFLS
                     VRNFLNVLDQITVLGVMAVGMTFVILIGGIDLAVGSVMALAMMVLGYLHVVAGVPMWLA
                     IPLALAAASLNGLIAGLLITRFNVPAFIATLAMMSITRGLANMVTDGQQIIGFPAWFNM
                     MAIVRFGGFLTLTVAVMIVVFIVGLLYQRYRHGGRVLYAVGGNAEVARLAGIDVQRATV
                     LVYVVCSFLAGLSGMVLAARLDSVQPSSGVSYELDAIAAVVIGGTSLSGGTGGIGGTII
                     GVLIIGVLRNGLNLLSVSPFMQQVIIGAVIVLAVTAETYRKRK"
     misc_feature    complement(16426..16439)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.76"
                     /tool="antismash"
     misc_feature    complement(16570..16585)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    16573..16593
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            16595..17404
                     /locus_tag="SMED_RS15700"
                     /old_locus_tag="Smed_3128"
     CDS             16595..17404
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011652254.1"
                     /locus_tag="SMED_RS15700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3128"
                     /product="transketolase"
                     /protein_id="WP_024310901.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.5e-10,
                     bitscore: 37.7, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.2e-06, bitscore:
                     25.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFR
                     VLRIWPEQPKHPDRDRFVLSKGHVALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNC
                     TKVPGIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGEMQEGSNWEAISSAAQ
                     FGLDNLTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKR
                     GSRPHCIVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL"
     gene            17404..18372
                     /locus_tag="SMED_RS15705"
                     /old_locus_tag="Smed_3129"
     CDS             17404..18372
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067336.1"
                     /locus_tag="SMED_RS15705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3129"
                     /product="transketolase family protein"
                     /protein_id="WP_012067336.1"
                     /transl_table=11
                     /translation="MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLG
                     GFRARWPDRLVNVGIAEQNMVGVGAGLANGGLLPFVCGAACFLTGRSLEQIKADIAYSN
                     ANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAHYDG
                     PVFLRLSRVGVPDLLPSGHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGI
                     EARVLNMATVRPLDLDAVVAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKIL
                     GVPGIFAPTGSAEFLLDEFGMSPAAIAEAAVALIARKPSRA"
     gene            18447..19916
                     /locus_tag="SMED_RS15710"
                     /old_locus_tag="Smed_3130"
     CDS             18447..19916
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067337.1"
                     /locus_tag="SMED_RS15710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3130"
                     /product="FGGY-family carbohydrate kinase"
                     /protein_id="WP_012067337.1"
                     /transl_table=11
                     /translation="MTTAILAIDQGTTNSKAVLVSTTGEILSRGASPVGIEHPQPGWVE
                     QNPLRIWESVQEAIAACLQKGPRSDILGIAISNQRESVTAWDAATGKPLGPVVSWQCRR
                     SAPACAELSAAGHAERVRALTGLPIDPMFPGPKMKWLLDRIPPGHEVRLGTIDAWLIHC
                     FTAGAIHACDAGNAARSQLYDLNRRAWSDELCDLFGVPKSALPEVCDSAARFGVTKNVP
                     GLKDGIPIASAIGDSHAALFGHGAFKPGDGKVTFGTGSSIMTTLPRFIAPEQGITTTIA
                     WSIAGRPTYAFEGNILVSAAALPWMAEMLGLSHVEDLIDLAATAEPRGPGFVPAFVGLG
                     APYWHADARALFSGITFNTTRAQMARAVTDSMAFQVHDVFKAMSAQSPTPLGRLYADGG
                     PSKNTFLMQCVADTLNHVITQCDAPEASALGAAYLAGLSLGVWPDLAAVASLPRAGKPV
                     LPRPCDAADRLMVWQDAIYRSTVPGPSIMSE"
     gene            19940..20890
                     /locus_tag="SMED_RS15715"
                     /old_locus_tag="Smed_3131"
     CDS             19940..20890
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014989283.1"
                     /locus_tag="SMED_RS15715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Smed_3131"
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="WP_012067338.1"
                     /transl_table=11
                     /translation="MGRLNELRLIARVAQMYHIESKRQAEIAEIMHMSQATVSRMLKRA
                     EQEDIVRTTVIPPAGTFADLETALRERYGLTEAIVIDCSEDRDGAIMARIGEAAAHFLE
                     VTLQQDEIVGVSSWSQTILRMVDNIHPLKNAKAKYIVQILGGMGDASVQTHATQLTARL
                     ARLTGGEPRLLLVQGITSSREAKLVMLADPVVRETMDLFGRLSLAIIGIGAVEPSELLA
                     RSGNTFSRQEMAMLHEAGAVGEISYRFYDKGGKPVETPLNDRVIGISLEDLRKTGRVMA
                     LAGGESKTQAIAGALRLGVIDVLVTDKFTAARLTA"
ORIGIN
        1 cgatcaagtc gccgcgctcg caagcgcgaa gtgccggtgg gattttcccc agctttccgg
       61 ccttgccatc tgtcgtccgc ctgtacgacg ctccagcgcc gcagagccgc ctcagtcgcc
      121 ctgtcccggc tccggagaaa aatacttctc gtactttcct tccaggccgt ccatctccgt
      181 agcctccggc agcggatccc gcttgacggt gatgttcggc cattgcgtgg agaaatctgc
      241 gttaagcttc aaccacatat ccagacccgg ctcggtatcc ggcttgatcg ccccagcggg
      301 acattccggc tcgcatacgc cgcagtcgat gcattcatcc ggatggatga cgaggaagtt
      361 ctccccctca taaaaacaat ccaccgggca gacttcgacg cagtccgtgt acttacagcg
      421 aatgcagtta tcggtcacga catacgtcat gaggtactcc agccaatgct cacatttgat
      481 ggcagacggc aatcaacggt gacactcgat cgcccgcgca tgctaggaat gtccggagcg
      541 catagctgcc gaagcagtcc tgaatgccat cctccgcatg gcttcgtgaa tcgggaacga
      601 tccaggggtg aaaccacgca tcggttcaac ctgctacacc tgccgtcgcc ccgaaaaaat
      661 gggcccggcg ctgcagcgtt gcttgtgacg taaaggcttt gacggccctt tgcaagaatt
      721 atccatgcgc gatttgcccc tatgggggca cagttttcca gcctcgggac cggcgtgccg
      781 aattccgttg cagggcacct gaaaggaagg gcaatcgggc gtcccgacgg tgcccggcgc
      841 gacgaaactc aatcgtcctc gtggtccgcg cccggccgca gccggtcggt ttcgcgacgc
      901 tcccgcttcg tcggccgccc tgctccgcgg tctcgcgtcg cctgctcgta aagcgtgggc
      961 ttgccggcgg gcgcggcggg cgtgagatcc tcgtaaagca gacgggcttc ctcgtagggc
     1021 cctcggcggg acccaggcag cagcacccgc aagaccagat cgcgccgctc cagcgacact
     1081 tcgagcatgt ctccggcctt tatctgggcg gacgattgcg tttcacgttt gccgttgacc
     1141 accacgtgac cggcctcgat cgccttctga gcgagcgagc gcgatttgat cagccgggca
     1201 aagaacagcc atttgtcgag ccgctgacgc gttgcagggg cggacggcgg ctgtttttcc
     1261 atggcccgaa cctatttctt catctgctcc ttcagagcag ccagcttggc gaaaggtgaa
     1321 tccggatcga tcggcttctc cttgcgtggc gggcgcccct cgaacttggc gggagacggc
     1381 ttgctgcgat cgtaccggtc gccccgctcc ttgcgctgtc cgcccggcct tccttccgaa
     1441 cccttgccct cctgaggctt gccttccctc ggcttgcctg gcggcttgcc ctgggcgccc
     1501 tgcctgcggc cgccctcgcg tccctcggtc tgggcatgcc gctgtccacc gcggcgctgt
     1561 tcgccttggc gaccgccttg ccgctgattg tcctgacgcg tgccgggccg ccacaggagc
     1621 accggcttgg attcagccgg cgtctcaggc tcggccggcg ccggtgtttc gtcgctggtc
     1681 ggcgcgactt cctgcccgct ggtcgcagca tcggccgctt ccgcttccgc ggccggtgca
     1741 tcgcgcgtct cagcctctgc tggcggtatg cgggccgctt cggcctctgc agccggttca
     1801 ccggtctgtt gagccccggc atccgtttcg ctcacggcgg cttctccggc aggtgtgtcc
     1861 gccggggtag cgccgttctg acttgccagg aatgcggccg cctcttcggc ggtcacggca
     1921 tcggcacgat agccgagccc cttgaggatc tcctccatgt cgtcaggcgt tgccccgagt
     1981 atggacagca tcgatgtcgt cgccacgaaa cggcggccgt cataggcgcc ctcgggacgc
     2041 ggcgacgtcc ccggcttcca ctggagaagc ggacggatga gatcggcaag ccgctcgagt
     2101 atatcgatgc gcaccgcgcg cttgccgagg aatcggaagc ccgcgagcct gtagaaggtc
     2161 cgctcgaagg aagggtcggt gacgacggag gtccgcccag cagcgagcat cgggatgagg
     2221 tcgccgtagc ccggcttgtc gagcccatcg tttttcagcg cccagagcag cgtgatcagc
     2281 tccgccggag cgggtttcaa aagcgcgggg aggaagatgt gataggctcc gaagcgaaca
     2341 ccgtatctgc ggatagatgc acggctctcc tgatcgagcg acttcacctc ttctgcaacg
     2401 tcgcgacgga agagcacgcc gaggttttcg acgagctgga aggcaagccc tttggcaagc
     2461 ccctccaggt cctcggcgcg cgagatatcg tccagcggct tcagcaccgt gctgatgtga
     2521 tgatttacga agcgctcgat ccgagcgagt acatgctcgc gcgcattggc ctggagctgc
     2581 tcgtcggcaa gcaggatcac ccggggacgc atgacatggt cgctcgccgt gagccgcgcg
     2641 accggatccc cgagccaacg gacgagaccg tccgacgaca gggccagatc gccattaccg
     2701 gccgcgtgga gacgggcggc gcgcgcttcg aattccagcg cgagcgcctt ctgggcggcg
     2761 ccctgcacgg ccttcgcgtc cgttccctcg ctgcccgcaa cgagcgtgaa ccggaaaccg
     2821 gctagctgac ccacatggtg tccctcgacg aagacatcac cattcacact gatttctgct
     2881 tccagcatcg cattctctct caggcgcttc atgagcacag atgtcctgcg atcaacaaag
     2941 cgtttcgtca accgttcatg tagcgcgtcg gacaatcgat cttcgatttc ccgcgtcttt
     3001 tcttgccagt gtgtcggatc ggcaagccac ccgggccgat tggacacata ggtccaggtc
     3061 ctgatctgcg caattcgcgc cgaaagtgtg tcgatttccc cgtccgtgtg atcggcacgc
     3121 cggacctgtt cggccatgaa atcctcattg accgtcccat ggcgaacgag gtcggcatag
     3181 atactcgaga tcagatccgc atgctgggcg ggcgtaatgc ggcggtagtc cgggagtgcg
     3241 caggcttccc acagcttctc cacgcgctcg gacgtcgtcg ctacgtcgac gatctccggg
     3301 tagcgcgtca gatgctcgag agcctgctga tcgacggccg ggagcgcccg cgccaacccg
     3361 gagaccgccg gtgccgcctc caggcttttc ttcagcgcct tcactgaaga ataatccagc
     3421 gccttggagc gccattgcag cacccggacg gggtcgaact catgcgattc gatccggtga
     3481 acaagctcct cctcgaaagg gtcgacgcgg cccgtgacgc caaacgtccc gtcccgaacg
     3541 tgcctgcccg cgcgccccgc cacctgcgcg agctccgccg gattgaggtt gcgatattga
     3601 taaccgtcga acttccggtc ctgggcgaag gccacgtggt cgacgtcgag gttcagcccc
     3661 atgccgatcg catcggttgc cacgagataa tcgacgtctc cctcctggta gagggccacc
     3721 tgggcattgc gggtccgcgg cgaaagagcg cccagaacga cggccgcccc gccgcgctgc
     3781 cgccggatga gctctgctat cgcatagacc tcgtcggccg aaaaggcgac gattgcggag
     3841 cggttcggca ggcgcgtgat ctttttggat ccggcataga ggagctgcga catacgcggc
     3901 cgttcgacca cggtgatgcc gggcagaaga tattcgagaa tgggccgcat cgtcgcagcc
     3961 ccgaggaaca gcgtctcgcc gcgaccgcga aggtgcagga ccctgtccgt gaagatgtga
     4021 ccgcgttcga gatcgcctgc gagctggacc tcgtcgatcg ccacgaaaga ggccgtcgtc
     4081 tcgcgcggca tcgcctccac cgtgcagacc gagtaccggg cccggtgggg cgcgatcttt
     4141 tcctcgcccg ttatcagcgc gacattatga tggccgacct tctccaccag gcgcgtatag
     4201 acctcacgcg cgagcaatct cagcggcagc ccgatgacgc cgctgtcatg cgcgaccatg
     4261 cgctcgatag cataatgggt cttgccggta ttggtaggtc cgagcaccgc ggttacaccg
     4321 cggccgctca ggatcatgga ttgaaaggac aagatctcga tcccaggcag tctttgcagc
     4381 gccgcacgtt tttcagacgc acgaagatcg ctgcagtgct tgaattgccg catgcctcta
     4441 ttctcaaacc ggtcccgctc caggaataga tgcattggag ccggcggggc tttcaccttc
     4501 cggcgggaaa cagatgccca tgcgacgcgc cgaacgcaag ggttcatgga caataaaaac
     4561 tcaaaagcgc ccaaccatat cttgcgcctc acgtagaact tgcggctcaa gattccggaa
     4621 cagcgccgga acgaatcagc gacgaatcgc tgactctctc tgattcactc tatgttcacg
     4681 gctatatatg ggcttcaaca tctagttacg caccatatgc tgaatccggg caagaaacat
     4741 acgtcgaaag gtcccaagcg gcctcttcat ttcgcagcat tgctctgaac cgcgcaaagg
     4801 attccgaatc caagagtttg gaatgattga aaaaaattaa cgggattcac gaggccggcg
     4861 cgcgaatccg ggaataggaa tcgcttcgcg ggtattcggc ttttgccggg cagttcgctc
     4921 gcgactcgtc ggcacggcca ttttcccctt tcgttcacca caacatgtag agccggatga
     4981 ggaacactgc gtgcggtctc ctgaggccga tccaacccaa aaaaccgtgg tccagccgcc
     5041 gaatgcccgt cgaaaaaaat ccggcgccgc aaagggcggc gggaacacag tcggtcagaa
     5101 aaaagtctca ggcgaagtac tggccaccat tggccgagat cgtggaaccg gtaatgaagc
     5161 cggcatcatc cgacacgagg aacacgacgc atcgcgcgac ttcttccggt tcgcccaggc
     5221 ggccgacggg tatctgcggg atgatccgct cgttaagcac cttctccggt acggcgagca
     5281 ccatttccgt gccgatataa cccgggcaaa tggcatttac cgtgattccc ttcgctgccc
     5341 cttcctgagc aagcgccttg gtgaagccga gatcgccggc cttggcggca gaatagttcg
     5401 cctgtcccat ctgccccttc tgaccgttga tcgacgagat gttgacgatg cggccgaacc
     5461 cgcggtcgcg catccccgac cagatcggat gcgtcatgtt gaaaacgccg gtgagattcg
     5521 tgcctatgac ttcgccccat tgttgcggcg tcatcttgtg gaacatcgcg tcacgtgtga
     5581 tgccggcatt gttgacgagg atatctaccg gccccaggtc cgcctcgacc ctggcaatgc
     5641 cgtcgacgca ggcctcgtaa ctcgagacat cccacttata aacggggatg ccggtctcct
     5701 gtttgaaagc ctgggctttt tcgtcattgc ccgcgtaatt cgcagccacc ttgtagcccg
     5761 ctgccttcag cgcgatggcg attgccgcgc cgatgccgcg cgatccgccc gtgaccaatg
     5821 ctaccctgct cattagtgcc tcccgctctg ttaagccaaa ttggcgaaaa tcgtccttcc
     5881 gcggcccgga gcccgggccg cctgtgcata tccggatctg gaagtcgccc ggctcaccgg
     5941 gcgtcggcta aaggcgttcc acgcacatgg cgacccccat gccgccgccg atgcagagtg
     6001 tcgcaaggcc cttcgagacg ttgcgccgct tcatttcaaa aagaagcgtg ttcagcacgc
     6061 gggctccgga cgcgccgatc ggatgtccga tggcgatcgc gccgccattg acgttgacga
     6121 tcgacgggtc ccaaccgaga tccttgttga cggcgcatgc ctgggccgcg aaggcctcgt
     6181 tggcctctac gagttcaatt tcggcgaccg accagccggc tttttcaagt gccttgcgcg
     6241 atgcggggat cgggcccgtg cccatgatct gcgggtcgac gcccgccgtg gcccaggaga
     6301 cgatgcgggc aagcggctgg atgccgcgcc ggccggcctc ggcctcggtc atcagcagag
     6361 cggcggcggc gccgtcattg aggcccgacg cgttggcggc agtgacggtg ccttccttgt
     6421 cgaaagccgg gcgaagcttc gcaatcgatt ccagcgtggc gccgtgacgt atgtattcgt
     6481 cctggtcgac agtgacgtcg cctttccgcg tcttgacgac gaaaggaacg atctcgtcgg
     6541 cgaagcggcc ggctttctgg gcggcttcgg ccttgttctg ggaggccagc gcgaattcgt
     6601 cctgctcctc gcgcgtaagc tgccatttcc gcgcgacgtt ctccgcggta gtgcccatgt
     6661 gatatccata gaaggcgtcc gtcaggccgt ccttgatcat cgtgtcgatc atcttgtaat
     6721 cgcccatttt cacgccgccc cgcaagtgcg cgcaatgcgg cgccatggac atcgactcca
     6781 tgccgccggc gacgatgacc ttcgcatcac cggttgcgat ctgctgcatg ccgagcgcca
     6841 cggcgcgcag gccggagccg cagagctgat tcatgcccca ggcggtcttt tcctgcggga
     6901 ctccggcttt catcgccgcc tggcgcgccg gattctgccc ctcgcccgcc ggcagcacct
     6961 gcccgaggat cacctcgtcc acttcgccgg cttcgacacc ggcccgctcc agaaccgcct
     7021 tgaccgcggc cgcgcccaat tcgtgcgcag gcgtattgcc gaaggcgcca ttgaaggagc
     7081 cgacggccgt gcgggcggcg ctggcgatga cgatcgaggg attgctcatg ggacgttcct
     7141 catatttgct ttgcctgatg gaggcagact ggcaaaggga ggggcgcaag tcaaacggcg
     7201 agttgcactg ccgcaaaagc ttcaggaggg cttgccgacg cttgttcgca cctgcgtcgc
     7261 cgcattgcac aaagagattg tcagtggcgc tcttttgcgg atactctgaa aagtacaata
     7321 aagacgggac gatgggtaag aggagaccct gatggggaaa aacgaaggcc agatcgttat
     7381 caagaaatat gcgaaccggc ggctctacaa caccggtacg agcacgtacg taaccctcga
     7441 tgacctggct gtcatggtga agaggggcga ggacttcatc gtacaggacg caaagtccgg
     7501 cgaagatata acccattccg tgctgacgca gattatcttc gagcaggagt cgaaaaccgg
     7561 taacacgctc ctgccgattt cctttctccg ccagttgatc tccttttatg gcgaccagat
     7621 gcagatggtc gtgccgagct atctcgaaca ctcgatgcag gctttcaccg aacagcaggc
     7681 tcagatgcgc gagcagatca ccaaggcctt cggtgagacg ccgatcggca agaacctcaa
     7741 agtgccgctg caactggtcg aggaacaggt ccggcgcaac accgaaatgt tccatcaggc
     7801 catgcagatg ttctcgccct tcatggcggc cccagccgca aaagaaagca agaaggccga
     7861 agcgaaagac atcgacgaat tgaaagaaca gcttcgagcc ctccagacga agctggataa
     7921 tctcggctga ctttcaggca ttcggagccg taccaaagaa aaagggccgg caatgccgac
     7981 ccttcgaatt tcatccgcga gtgatatgcg cttatgcgct ttccttcggc gtcagaacct
     8041 ggcggccgcg atacatgccg gtcttcaggt cgatgtgatg cgggcggcgc agttcgccgg
     8101 aattcttgtc ttcgatgtag gtcggagcct tgagggcgtc agcggaacgg cgcatgccac
     8161 gcttggacgg gctcgttttt cttttcggta cagccatttc attctccact tatcgggcaa
     8221 aacactgttc agcagccgaa aatggccggg tcaaacagat gtcgatctcg gaatttcgcg
     8281 cgcttataca tgccggaccg cagtttgacc agtccccgcg cacaaatttt cgattcaggc
     8341 ttcatcctcc ggaacgatcc agggctcggc tttcgcggcc tcttcccact tgcggaaggc
     8401 cggatgccct cggacggccg ccatataggc aagcgtcgcc ggatctttca cgaggtcata
     8461 gacttcgaag cggatgacga caggtgcgaa catggcatcc gcggcggtga accggccaaa
     8521 gaggaacgga ccgccagacc gcgcggtttg ctcgtgccag atcgtctcga tccgcgccac
     8581 atcctcggta acgccgtcgg gcagatcgat cgccttcttc gaccggcgga tgttcatggg
     8641 gcaggcgccg cgcagtgcct ggaagccgga gagcatctcc atcgaatagc tccgcgcgcg
     8701 tgcgcgatcc tcgcggctat cgggccagag gccagcctcc ggaaagagct ccgccgcata
     8761 ttcgataatg gcgagcgatt cccacacgcg ggtttcgcca tgatggagta ccggaacacg
     8821 tcctgtcggc gacatctcgc gaatgcgggg gttgccggcg ggaaagtcga agggaatgac
     8881 gacctcttcg aacggaatgc cgctggccgt gagtgccagc catggccgga gcgaccagga
     8941 cgaatagttc ttgttgccga catagaggac gagcttggcc atgatttttg tctccgcctg
     9001 aagttccgga cggcagcctt gccacatcaa aggccgacag accaatgaat tggattcatc
     9061 tcaatcataa agacacgtga tatagccgcc ggagcggctt gcccggcgct cgatcaccga
     9121 ggcgagacgc cgcagaccgc gccccggttt gccggcgttg cggtcgaccg gatttggcag
     9181 cgatacggcg agaagagcag cctgacggcg cgagagctcc gccgccgaaa cgccgaaatg
     9241 atgccgggct gcagcttcga tcccgtaaat gccctcgccc cattcggcga cgttcagata
     9301 aatctccatc aggcgccgtt tgctccagac gaaatcggcg gcgaccgcga gcggcagctc
     9361 catcgctttg cgcacgaagg aacggccatt ccagaggaac aggttcttgg cggtctgcat
     9421 cgggatcgta ctggcgccgc gcgtctgtcc gccgtcgagc gcatcctcta cgacggcgcg
     9481 catctgagcc caatcgacgc cggcatgcga gcagaactgc ccgtcctccg acatcattac
     9541 cgactggacg agcaccggcg cgatgtcgtc gaactcgacc cattgccggt catagccgcg
     9601 cgccagcacg aggtcgcgca gcatcagggt agagaccggg tgaatgaact cggcgagata
     9661 gaagaagatc agcgcgtagg gcaggaacag gatggagagc acgagtagaa cgaggcggcg
     9721 acgacgcgca cgccacgtcc gtcgcacggc cgtctgccgg ccggcgggca attccgcttc
     9781 ctcgcgctct tccgaaatga tgtccacgcc ccgcccgtcc acctctttcc cgtccgcccg
     9841 gttttccatc cacctccctc atatgccatg gcgagccaaa gttgaacggc ctttctggca
     9901 aaaggcaagg ctcagaaggt gcatcatcac cgagaggctg tgcgcgctgc gacgtgaaag
     9961 cccgttgaaa gccgctccgc cgcatgccaa agagcctcgt atgacagacg aaagatcatc
    10021 ctttccagag cgcctcaagt ccaatgcggt cgcggtcgaa gcgctgctcg agacattgct
    10081 cgacccggcc gtgcgtggcg gcgaaatttc ccgccctgcg aacctgctcg aagccatgcg
    10141 tcatgcggtg ctcaatggcg gcaagcggct gcggcccttt cttgtcagcg aaactgcggc
    10201 gctcctcggc ggcgatgtgc aagcggcact gagaattggc gctgcgctcg aatgcattca
    10261 ttgctactcg cttgtccatg acgatctgcc ggcgatggac aacgacgaca tgcggcgcgg
    10321 aaaaccgacg gtgcacgtcg ccttcgacga ggcaaccgcg atcctcgcgg gcgatagcct
    10381 gctgaccttc tccttcgaca tcatcgcggc gccggagaca gccctttccg atcgccagaa
    10441 gaccgcgctc gtgctggcgc tcgcacgggc ggcagggcac gggggcatgg ctggggggca
    10501 ggcactcgac cttgccgccg aaaagagcgc ccccgatgag acgggcatcg tactcctgca
    10561 atcgatgaag accggcgcgc ttctccgctt cgcctgcgag gcgggcgcga tcatcgcgga
    10621 tgcggcggcc gaggaccgcc agcgtctgcg ggccttcgga gagaagatcg gcctcgcctt
    10681 ccagcttgcg gacgatctgc tcgacctcac cgccgacgcc gcgcacatag gcaaggcaac
    10741 cggaaaggat gccgcgcgag gaaagggtac actcgtcgcg ctgcacggac agccctgggc
    10801 cgagcagcgg ctcgaaagcc tggtggccga ggcggaagcg ctccttgagc cttatggcgc
    10861 ccgttcggag gtccttgccg agaccgctcg tttcattgcc aaccgcagga actgatagat
    10921 gagcagattc tggtcgccga tcgttgccgc cttgaagcct tacgttcccg gtgaacagcc
    10981 gcggatggcg aacctcgtca agctcaacac caatgagagc ccctatggcc cctcggaaaa
    11041 agcgctggag gcgattcggg cggcggctga catggatctc aggctttatc cggatcccgt
    11101 cgctctcggg ttgcgggagg cgatcgccag gcgctacggc atgtccgtcg gcgaggtctt
    11161 cgtcggcaat ggttccgacg aggttctggc ccacaccttc gcggcgcttt tgaaacacga
    11221 tcggccgctg ctttatcctg acatctccta cagcttctat ccgacctatg cgggcctttt
    11281 cggcatcgaa gcggtcgaga ttccgctgaa cgccgacttc cgcatcgaaa ttgcaggcta
    11341 tcgccgccct gccggcgcca tcatcctgcc gaatccgaat gcgccgacgg gaatcggcct
    11401 gccgctttcc gacattgaaa ggctggtgag cgagcattcc gaccagcccg tggtcgtcga
    11461 cgaggcctat atcgacttcg gcggcgaatc cgcgatcgca ctcgttccga aatacgagaa
    11521 cctgctcgtc gttcagacct tctcgaagtc acgtgcgctt gccggtcttc gcgtcggctt
    11581 cgcgataggc caaaggccgc tgatcgaggc gttggagcgc gtcaaggata gtttcaattc
    11641 ctatccgctc gggcgcgccg cccttgcggg tgcaacggct gcgatcgagg acgaggcctg
    11701 gttcgagaag acgcgcgcca agatcctcgc cacgcgggcg gcattgacga aggggctcga
    11761 agcgcgcggt ttcgaggtcc tgccgtctca ggcgaatttc gtcttcgccc ggcatcagaa
    11821 ccacgcgggc cagacgctgg cggcgaaact ccgcgaacgc gcggtcatcg tccgccgttt
    11881 tgccaagccc cggattgagg atttcctgcg catcaccatc ggcaccgatg atgaatgcgc
    11941 caaactggtc gcggcgctcg acgaaattct gtgagatcgc aggtcagatt gaagcggcac
    12001 cggcgagatt gcggcgccgc ctcctgaccg gcgatatcac cagcagcaga agccgccatc
    12061 aacgagaagg tctactccgg ttacgaagct cgccgcatcc gacagaagga aaacggccgg
    12121 gccgaccatt tcgtccacgc cagccatgcg ctgcatcggc gtctgttcct cgaagagcct
    12181 ggtctggtgc accatttccg gtctagtatt cataggtgtt gccgtatagc ccggactgat
    12241 ggtgttgacc cggatgccgc ggcctaccca ctccatcgcc atggacttcg acatgtgaat
    12301 tacacccgcc ttagaggcgt tgtagtggca ctggttaagt cctcgattca cgatgacgcc
    12361 ggacatcgag gcgatgttga cgatcgaccc gcgtccgttc ctcaacatgg cgcgcgcttc
    12421 cgcctggcag gagaggaaaa cgcctttcag attgacgtcc atcatcgtct ggaactgagt
    12481 ttcctccatc tcctccgccg gatgagcatt ggcgatgccc gcggcgttga gcgcgagggt
    12541 cagcgggccc agctccgctt ctgtgcgcgc aaccgcctcg tcgagcgccg cgccgctggt
    12601 gacatcagcg gcgatctgaa tgctgcgacg cccagccttt tcgatgagat cggccgtctt
    12661 cgcgagacca tcatcggtcc gtcggtctag taacccgaca tctgcgccgc actgtgcgag
    12721 accgatggcg atgcgttggc cgatgccgct gcccgcgccg gtcacgaggg cgacgtttcc
    12781 ggcaagatcg aacaatttcg gtgcgtcaag actgatttca gacatatggg ttctttcctg
    12841 cttagatcgt tgccagttcc atgacagaga cgtcgttcgc atcctcgcgg ttcaggatgc
    12901 cggcctgctt gccctgcgcc atgaccagga tgcggctgga gacgccgagc acctcttcga
    12961 gatccgagct gaccacgatg actgcgacgc cctcgcgggc gagatcgatg atgagatcgt
    13021 agatcgacga gcgggcgcct acgtcgatgc cgcgcgtcgg ctcgtccagc acgaccacct
    13081 gcggttttcg cgccagccat ttggcgagca ccactttctg ctggttgccg ccggaaagct
    13141 ccccggcatt ctgccccccg cggcctttta ctccgaacgt cttgatgcac tcctcggcga
    13201 actgccgaat gcggcgcgag gagacccagc cgctgcggga gatttcgccg aggttggcat
    13261 agccgatatt ttccgcgatc gaatgatcga gcacgacgcc ctggagcttt cgatcctccg
    13321 gcacgagaac gatgccgttg cggatcgcat cgatcggaga gcggggcgtg acgggcctgc
    13381 cgtgcagcag gacttcgccg ctggaaatgg ggtcggcgcc gctgatggcg cgtacgagtt
    13441 cggtccggcc ggctcccatg aggcccgcaa tgccgaaaac ctcgcccctg cgaaccgaaa
    13501 agctgatgtc ccggaatgcg ttggacggcg acgagagatt tcgtacctcc agcgtcacct
    13561 ggtccgtcgg ggccggaagg gtcgggaaca tgcgctcgag tgagcgcccg accatggcct
    13621 cgacgatcgt gcgtatcggc acgtcgccac tctcgaactc ctgcaccttg gcgccgtcgc
    13681 gcatcacgac aatgcggtcg gcgatcttgc ggatctcctc caggcggtgc gaaatgtaga
    13741 tgatgccgac gccttccgac ttcagccgtt cgatctgccg gaagaggagc tgggtctcct
    13801 cggcgccgag cgcggccgtc ggttcgtcga gaatcaggag gcgcgcattg agcgtcaacg
    13861 ccttggcgat ctcgatgagc tgctgcttgc cggtcgaaag cccgtcgacg aggcgatccg
    13921 gcgagatgtc gagaccgagc cggtgcaggc cgctgcgtgc ccgatcttcc atagttttgc
    13981 gatcgatccg ccccgccttc atcgggtagc ggccgacgaa cacgttctcc gcgatggaga
    14041 gcttcgggag cagtttcagt tcctgatgga tcatgcctat cccctcctcc atcgcggcac
    14101 ggggatctgc gggggcgtag gccctgccca gccaggtcat ttcgcccgct gagggttgca
    14161 cggtgccgga aataatgttc gacagcgtcg attttccggc accgttttcg ccgagcagcg
    14221 ccaccacctc tcccggatgg atatcgaggt cgataccgtg gagaaccttg atcggaccgt
    14281 aggatttgcg gatgcgacgg agcgacagga tgggagagtg gggcgtcatg gcgctgctgc
    14341 ctttcggcta tcgggttacg gatggttctt tacgaattcc ggagcgttgt cgcaggtcgt
    14401 cagcacggca ttcggcgtct gacgctcttc gaccttctcg cccgccgcaa cggcaagtgc
    14461 ggattcgacg gcaagaacgc ccattttttg cgtgctctgc gttgcggtgg cgatgaacgg
    14521 gcccttgcac ctggcgaggt attcgagcgc cgagacgtcg ccgtcatagc cgccgatgat
    14581 caccttgtcg gagagattgg cgacgtcgac cgccttggcc gcccccatgg cgagaccgtc
    14641 ggcctggccg aaaatgatcg tgatgtccgg atttgcctgc agcatgttct gcgcgatcga
    14701 gaagccttca tcggccgacc acatgttgct ccactgctgg tcgataagct cgacgccctt
    14761 gttctcgtca atggcgcgct tgcagccggt gaagcggtcg acctccggcg ttgtgccctt
    14821 ctgcccgtgg atgattgcca tcttgcccga gccgccggcc ttctcgatga tgaacttgca
    14881 gacggcgtag gcggattcga cgctctctcc ggcgatgaag gtgtcgcccg gcgcaccctc
    14941 cgggacgcgg tcgacgttga tgaccggaat gccggcttcg cgggcaaggc gggtcgggac
    15001 cgcagccgcc gcggcaccgg ccgggatata gatgaaggcg tcgatgtcct ggatcatcag
    15061 gtcctgtacc tggctgacct gcgtgttggt gtcgttcttc gcgtcgacga ccaccacttc
    15121 gaggcccttt tccctggcgt gcttttcgac accgagcttg atctggttga agaagtcggc
    15181 ctgaagattc ggaacagcaa ggccgatctt cttgacctcg gctgcggatg cgggaagcgc
    15241 aaggaccgaa gcggtggttg cggccaccag cagtgtggac agtttcatag tttctcctcc
    15301 gatttgcccg gtggcgccct gccctcgcag gaagtcacct tctctttgcc ggccggcacc
    15361 attgctggcc gttttcagcg ccccaccgaa gttcggcaac ggggcgaatg tcgctatttc
    15421 cgcttgcggt acgtttccgc cgtgacggcg agtacgatga cggcaccgat gatcacctgc
    15481 tgcatgaagg gagacacgct gagcaggttc agaccgtttc gcaggacacc gatgatgagc
    15541 acgccgatga tggtgccgcc gatccccccc gttccgccgg aaagcgaagt accgccgatg
    15601 acgaccgccg cgatggcgtc gagctcatag gacacgcccg acgacggctg gaccgagtcc
    15661 agacgagccg caagcaccat gccggaaaga cccgcgagga agctgcagac gacatagacg
    15721 agcacggtcg cgcgctgaac gtcgataccg gcaaggcgcg ccacttcggc attgccaccg
    15781 acggcgtaaa gcacgcgccc gccatgccgg tagcgctggt agagaagtcc gacgatgaag
    15841 accacgatca tcacggcaac ggtcagcgtc aggaagccac cgaagcgaac gatggccatc
    15901 atgttgaacc aggccggaaa gcctatgatc tgctggccgt cggtgaccat gttcgcaagg
    15961 ccgcgcgtga tcgacatcat ggcgagcgtg gcgatgaagg ccggtacgtt gaagcgggtt
    16021 atgaggaggc ccgcgatgag gccgtttagc gaggcggcgg cgagcgccag gggaatggcg
    16081 agccacatcg gcacgccggc cacgacgtgc aggtagccga gtaccatcat cgccagcgcc
    16141 atgaccgacc cgaccgcaag gtcgatacct ccgatcagga tgacgaaagt catgccgaca
    16201 gccatgacgc ccagcaccgt gatctggtcg agcacattga ggaaattccg caccgacagg
    16261 aacttgtccg tcgcgaaggt caggaaaagg cacagcacga tcagcccgat cagcggaccg
    16321 gtcgcgccct tcagtgacgg aagcagcctt acggcagccc cttgcttgtc ttgcaccgca
    16381 gcccgcatgc gccgtcctcc cgcatagccc gcttcccgtt gccggtaagc ataattattc
    16441 attactgtgt gtaaattcat acacgaccaa tcctgaggct gtcaatacga gggaggctgc
    16501 aatctcgcgg ttgctattgc ggaattccgc ttgacttgcg agaggggcgt gcaaatatat
    16561 gatcagtagc atatttattc acaatgagga tttcatgcag ccgaacgatc tcgaccgcat
    16621 cgctcaacag atccgacttc gcgatctgca agcggttttc gaagccggcg ccggccacat
    16681 cggcggagag atgtccgcca tcgacattct gacggcgctc tattttcgcg tgctgcgcat
    16741 ctggcccgaa cagccgaagc acccggaccg cgaccgtttc gtgctgtcga aaggccatgt
    16801 ggcgctggcg ctctatgtga cgctggccaa gcgaggcttc attccagagg aagaaatcgg
    16861 cacattcctg aagccgcatt cgcgcctcaa cgggcatccg aactgcacca aggtgccggg
    16921 catcgagacg aataccggcc cgctcggcca cgggctgccg gtggcggtgg gcatggcgaa
    16981 ggcggcaaag ctgacccgcg cgaaatatca cacctatgct ttgaccggtg acggcgaaat
    17041 gcaggaagga tccaactggg aggccatctc atcggccgcg caattcggtc tcgacaacct
    17101 gaccctgatc atcgaccaca accgcttcca gcagggcgcc gctctgaagg ataccaacaa
    17161 tctcgctcca ttccccgcca aactcgaagc cttcggctgg gatgtgaccg agatcaacgg
    17221 caatgccatg gatgaagtcg ttccggcgct ggaaaagcgc ggcagtcgcc cgcactgtat
    17281 cgtcgcccat acgaacaagg gccacggcat atccttcatg caggacaagg tcgactggca
    17341 ccacaaggtg ccgaacgacg aacaatacaa gattgccgtg gctgagcttt cggaggccct
    17401 gtgatgaacg ccgtgacatc gtctgccaag ttgcacgatt gccgtgacgc cttcgttacg
    17461 gtgctggagc gcctcagtgc ggataacccc aggatcgtgg ccgtctgcaa cgactccgtc
    17521 ggctcctcca agctcggcgg cttcagagcc aggtggccgg accgactggt caatgtcggc
    17581 atcgccgaac agaacatggt cggtgtcggc gctggccttg ccaatggcgg actgctgccc
    17641 ttcgtctgcg gcgccgcctg tttcctcacg ggccggtcgc tggagcagat caaggccgac
    17701 atcgcttatt ccaacgcaaa cgtgaagctc atcggcattt cctccgggat ggcctatggc
    17761 gagctcgggc cgacgcacca ctccatcgag gatttcgcct ggacccgcgt gttgccgaac
    17821 cttccggtca tcgcaccctg cgactcggtc gaaaccgccg cggccgtcga atgggccgcc
    17881 cattatgatg gcccggtttt tctgcgcctg tcgcgcgtcg gcgttccgga cctgctgccg
    17941 tccggccaca cattcgaact gggcaaggcc aacctgttgc gggacggcga cgcgatcacc
    18001 ctcgtcgcca acggcacggt gacccaccgc atcctgaagg ctgccgatct gctggcggca
    18061 gagggcatag aggcacgcgt gctgaatatg gcgacagtcc ggccgctcga tctcgatgcc
    18121 gtcgtggccg ccgcgcgcga gaccggagcc atcctgacgg cggaagagca ttccaccttc
    18181 ggcgggctcg gttcggccgt ggccgaactt gtcgtggccg aagcgcccgt gccgatgaag
    18241 atcctcggcg ttccgggaat tttcgccccg accgggtcgg ccgaattcct gctcgacgaa
    18301 ttcggcatgt cccctgccgc catcgccgaa gcggccgtcg cactgatcgc acgaaagccc
    18361 tcccgcgcat gatcatgcgc aggtagattt cgtgccgggc gcggcaatcc tcctgccgcg
    18421 ccccattcct gtcagccgga gccgccatga cgactgccat tctcgccatc gaccagggca
    18481 ccacgaattc aaaagccgtt ctcgtttcga cgaccggtga gatcctctcg cgtggcgcat
    18541 cgccggtcgg catcgaacat ccgcagcccg gctgggtgga gcagaacccg cttcgcatct
    18601 gggaatcggt tcaggaggcg attgccgcct gcctgcagaa gggaccccga tccgacatcc
    18661 tcgggatcgc gatctccaac cagcgcgagt cggtcaccgc ctgggacgcc gcaacgggca
    18721 agccgctcgg cccggtggtc agctggcaat gccgccgcag cgcgccggcc tgcgccgaac
    18781 tcagcgccgc aggccatgcc gagcgcgtcc gggcgctcac gggtctcccc atagacccta
    18841 tgttccccgg tcccaaaatg aagtggctgc tcgatcgcat tcccccggga catgaggtcc
    18901 ggctgggcac gatcgacgcg tggctgatcc attgcttcac ggctggcgcg atccatgcct
    18961 gcgatgccgg caatgccgcc cgcagccagc tttacgacct caaccgccgg gcctggagcg
    19021 acgagctttg cgacctgttc ggcgtaccca aatccgccct gccggaggtg tgcgacagcg
    19081 ccgcccgctt cggcgtcacg aagaatgtgc cggggctgaa ggacggaatc ccgatcgcct
    19141 cggcgatcgg cgacagccac gccgcgcttt tcggccacgg ggccttcaaa cccggcgacg
    19201 gcaaagtgac cttcggcacc ggctcttcta tcatgacgac cctaccccgc ttcatcgctc
    19261 ccgagcaggg aattacgacg acgatcgcct ggtcgatcgc cggccggccg acctatgcct
    19321 tcgagggcaa cattctcgtt tcggccgcgg cccttccatg gatggccgaa atgctcggcc
    19381 tttcccatgt ggaggacctg atcgatctcg ccgccaccgc cgagccccgc ggcccgggtt
    19441 tcgtgccggc cttcgtgggt ctcggcgccc cttactggca cgccgatgca cgagcgctgt
    19501 tttccggcat aaccttcaac acgacgcgcg cccagatggc gcgtgcggtc acggactcaa
    19561 tggccttcca ggtccatgac gtcttcaagg cgatgtcggc acaatcgccg acaccgctcg
    19621 gccgactcta tgcggatggc gggccgagca agaacacttt cctgatgcaa tgcgtggccg
    19681 ataccctgaa ccatgtcatc actcagtgcg acgcgccaga ggcctcggcg ctcggcgcag
    19741 cctatctggc gggtctctcg ctcggcgttt ggcccgatct cgccgctgtc gcttcactgc
    19801 cgcgcgccgg caaacccgtg ctgccgcgcc cttgcgatgc cgcagatcgc ctcatggttt
    19861 ggcaggacgc aatctaccgc tcgaccgttc caggtccttc aattatgagt gaataaaaat
    19921 tcaccactgg aggatcccga tgggacggct caacgagctt cgactgatcg cccgcgtagc
    19981 ccagatgtac catatcgaaa gcaagaggca ggccgagatc gccgaaatca tgcacatgtc
    20041 gcaggcaacc gtttcccgca tgctgaagcg cgccgagcag gaagacatcg tgcgcaccac
    20101 ggtcattccc cccgccggta cctttgcgga tctcgaaact gcattgcgcg agcgctatgg
    20161 cctgaccgaa gcgatcgtca tcgactgttc ggaagatcgc gatggagcga tcatggcgcg
    20221 catcggcgag gcggctgccc atttcctcga agtcacgctg cagcaggacg agatcgtcgg
    20281 ggtatcgagc tggagtcaga ccattctgcg catggtggac aacatccacc cgctgaagaa
    20341 cgccaaggcg aagtacatcg tgcagatcct cggcggcatg ggcgacgcct cggtgcagac
    20401 ccatgccacg cagctgaccg cgcgccttgc aagactcacc ggcggcgagc cgcgattgct
    20461 tctcgttcag gggatcacct cctcacgcga ggcgaaactc gtcatgctcg ccgacccggt
    20521 ggtgcgcgag acgatggacc tcttcggccg cctcagcctt gcgatcatcg gcattggcgc
    20581 ggtggaacca tcggaactgc tcgcccgctc cggcaacacc ttctcccgcc aggaaatggc
    20641 gatgttgcac gaggccgggg cggtcggcga gatttcctac cgattctacg acaagggcgg
    20701 aaagccggtc gaaaccccgc ttaacgaccg cgtaatcggc atctcgctgg aagacctgcg
    20761 caagaccggc cgcgtcatgg cgctcgcggg cggcgaatcc aaaacccaag ccattgccgg
    20821 cgcccttaga cttggcgtta tcgatgtgct cgtcaccgac aagttcacag cagctcggct
    20881 cacggcctga tctgaagatc ggtcctggcc cgttg
//
