LOCUS       NC_009727              22970 bp    DNA     circular CON 20-MAR-2024
DEFINITION  Coxiella burnetii Dugway 5J108-111, complete sequence.
ACCESSION   NC_009727
VERSION     NC_009727.1
KEYWORDS    RefSeq.
SOURCE      Coxiella burnetii Dugway 5J108-111
  ORGANISM  Coxiella burnetii Dugway 5J108-111
            Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
            Coxiellaceae; Coxiella.
REFERENCE   1  (bases 1 to 2158758)
  AUTHORS   Beare,P.A., Unsworth,N., Andoh,M., Voth,D.E., Omsland,A., Gilk,S.D.,
            Williams,K.P., Sobral,B.W., Kupko,J.J. 3rd, Porcella,S.F.,
            Samuel,J.E. and Heinzen,R.A.
  TITLE     Comparative genomics reveal extensive transposon-mediated genomic
            plasticity and diversity among potential effector proteins within
            the genus Coxiella
  JOURNAL   Infect Immun 77 (2), 642-656 (2009)
   PUBMED   19047403
REFERENCE   2  (bases 1 to 2158758)
  AUTHORS   Beare,P.A., Unsworth,N., Andoh,M., Voth,D.E., Omsland,A., Gilk,S.D.,
            Williams,K., Sobral,B., Kupko,J.J. III, Porcella,S.J., Samuel,J.E.
            and Heinzen,R.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2008) Coxiella Pathogenesis Section, Laboratory of
            Intracellular Parasites, Rocky Mountain Laboratories, National
            Institute of Allergy and Infectious Diseases, 903 S. 4th Street,
            Hamilton, MT 59840, USA
  REMARK    Protein update by submitter
REFERENCE   3  (bases 1 to 2158758)
  AUTHORS   Seshadri,R., Samuel,J.E., Myers,G., Kim,M., Huot,H., Durkin,A.S.,
            Dodson,R.J., Daugherty,S.C., Li,J. and Harkins,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2007) The Institute for Genomic Research, 9712
            Medical Center Dr, Rockville, MD 20850, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000017105.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 01:44:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,344
            CDSs (total)                      :: 2,293
            Genes (coding)                    :: 2,077
            CDSs (with protein)               :: 2,077
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 124 of 216
            Pseudo Genes (incomplete)         :: 95 of 216
            Pseudo Genes (internal stop)      :: 37 of 216
            Pseudo Genes (multiple problems)  :: 39 of 216
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:18:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1209781
            Orig. end                         :: 1232751
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000733.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Dr. James E. Samuel,
            jsamuel@medicine.tamhsc.edu.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22970
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22970
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22970
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12970](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12970)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(<561..2807)
                     /locus_tag="CBUD_RS06160"
                     /old_locus_tag="CBUD_1234"
                     /old_locus_tag="COXBU7E912_1234"
                     /pseudo=""
     CDS             complement(<561..2807)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1295: Sel1 domain
                     protein repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF019843.4"
                     /locus_tag="CBUD_RS06160"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1234"
                     /old_locus_tag="COXBU7E912_1234"
                     /product="tetratricopeptide repeat protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKRIAVFILTLSFFSISYSDKNPVFQEYYEGNYRAAETGLKQLAE
                     KNNGEATFYLATMYMNGFGVRRDFEKGFDYMTRAAELKYLPAQLYLGNYYFQQQKDLEK
                     AVPWFKKAADAGDAGAQLFTGISYLNGYGVKKNIDIARKYFIGAAQNEIPMGQYELAKI
                     FLASRHAGDRRMGRIWLTKAADKYNYPDAQYLLGTMLYTGNEAEKDPVKGVEWLEKAAA
                     NGSKEASKTLDKINRINTSDAKANSENRSEPTPWQIMVGLMQKAGVQLNNPITVTASIN
                     NFTKTPKSMALDKNSIIKLNLNLANSKDIPPEKILSYMTQLNYKEEKFDLTVPAYPFKM
                     PPGANNYKEAFQSLSRVANYGYAQSLFRLGQMYENGLGVQKDPETAFQLYMKAAEQNYL
                     KAQYAIGTYYLQGKGVPQDYEKAISWFIRAALKGSLQAQFVLGNIYERGIKASNNKILF
                     KNFDRAKAMYSLAVGGNLPIAAYRLAELYVSGFLNPDNNVSLETQNWKKAYALYQKAAK
                     SGLEKADVALGYFYLQQNQTTLAEKTFEIAQKAYQTNDPEAAMLLAILYDRGFGVNSNS
                     RKSAEILEKLSKQNNAIAQFMLGNYYLKNKRKENIAISLLEKSANQGNGYAQYNLAILA
                     KQNKYTKPGENFLSLLIRAANHYDKIKEILADYYLLDTPVPGSEKKAVAIYQELANKQD
                     PAAELKLGFMNEHGLLFPKDYHKAEEWYQKSAEQGNPIAQYLLGNMYYLGRGVDR"
     gene            complement(2804..3358)
                     /locus_tag="CBUD_RS06165"
                     /old_locus_tag="CBUD_1235"
                     /old_locus_tag="COXBU7E912_1235"
     CDS             complement(2804..3358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820136.1"
                     /locus_tag="CBUD_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1235"
                     /old_locus_tag="COXBU7E912_1235"
                     /product="enhanced entry protein"
                     /protein_id="WP_010958030.1"
                     /transl_table=11
                     /translation="MEKGCKKFLVLLGAALYFLIPGAEGKILRYPYGCYPMGYKFNYYN
                     LILQPTGRYHPQTIYFIHNVSKQAISLFQARSNDEPYIIHINTTIAPNAWSVLATDEKK
                     VKYICTNGGNDILKLKIINCSKVLDICEFPRTRFGDNNRGNYWAVENIGSSTAAVSAIR
                     WYGILLIDPKKRDLENEGSLL"
     gene            complement(3361..4108)
                     /locus_tag="CBUD_RS06170"
                     /old_locus_tag="CBUD_1236"
                     /old_locus_tag="COXBU7E912_1236"
                     /pseudo=""
     CDS             complement(3361..4108)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0071972 - peptidoglycan L,D-transpeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820137.1"
                     /locus_tag="CBUD_RS06170"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1236"
                     /old_locus_tag="COXBU7E912_1236"
                     /product="L,D-transpeptidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKAMERAIFIVLVSLLGASIAFGADSPNEYYGTGLCGKSGFECIK
                     VQRGQSWQNLFPDENQRDLVQRLNRTDTYLYPGKTLAVPKDLKDATIYSISPFPLRIKK
                     LGEKLIMVNQDQLAWGAYDPEGQLIKWGPISSGKNYCRDVNRSCETITGIFYVFHKKGP
                     GCKSNVFPVETSGGAVMPYCMFFFKGYALHGSNEVTGYRDSHGCVRLFKRDAKWLNENF
                     VNVATKDGHLGTKVVVEKLTIGE"
     gene            complement(4395..4547)
                     /locus_tag="CBUD_RS06175"
                     /old_locus_tag="CBUD_1237"
                     /old_locus_tag="COXBU7E912_1237"
     CDS             complement(4395..4547)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_002332986.1"
                     /locus_tag="CBUD_RS06175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1237"
                     /old_locus_tag="COXBU7E912_1237"
                     /product="hypothetical protein"
                     /protein_id="WP_005768427.1"
                     /transl_table=11
                     /translation="MIILALLEFLLFKEVIVMKMQFIQKIVANKIAKVASSSAALCGVP
                     VCTHG"
     gene            complement(4619..4756)
                     /locus_tag="CBUD_RS06180"
                     /old_locus_tag="CBUD_1237a"
     CDS             complement(4619..4756)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820138.2"
                     /locus_tag="CBUD_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1237a"
                     /product="hypothetical protein"
                     /protein_id="WP_010958032.1"
                     /transl_table=11
                     /translation="MRKLPMPPPKGTTETESFKRLAKAYFKSPVIQTSLIFLSLQLLGC
                     "
     CDS             complement(4809..4898)
                     /gene="allorf_1214590_1214679"
                     /locus_tag="allorf_1214590_1214679"
                     /protein_id="allorf_1214590_1214679"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRMSMPFSPHSRSPISCEKAMRRSWGRSE"
     CDS_motif       complement(4875..4898)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRMSMPFS"
                     /locus_tag="allorf_1214590_1214679_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4809..4874)
                     /prepeptide="core"
                     /locus_tag="allorf_1214590_1214679_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="2367.7"
                     /monoisotopic_mass="2366.2"
                     /core_sequence="PHSRSPISCEKAMRRSWGRSE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRMSMPFS"
                     /leader_location="[4874:4898](-)"
                     /alternative_weights="2385.7"
                     /alternative_weights="2403.7"
                     /alternative_weights="2421.7"
                     /alternative_weights="2439.7"
     gene            5015..6127
                     /locus_tag="CBUD_RS06185"
                     /old_locus_tag="CBUD_1239"
                     /old_locus_tag="COXBU7E912_1239"
     CDS             5015..6127
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011996988.1"
                     /locus_tag="CBUD_RS06185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1239"
                     /old_locus_tag="COXBU7E912_1239"
                     /product="hypothetical protein"
                     /protein_id="WP_011996988.1"
                     /transl_table=11
                     /translation="MSRDPKSNPQYPITEPELSLLEKQLSEQFPLPQKSSGFDPFPFSN
                     EEEVDKTIDKLEKLEPFDNEKINVAVCFGESYFLSLLPTLQKLNIKVVIMADIESRLHQ
                     HTRHLLNSLLENDTRKGFFKSYGTKNPAVGWEEAASGFGGPRLLDNLSLIKQLCLDTPS
                     YLGQYHFCALDGEKETADKRYQVCRKAAQSLKVVQVGLNLFNIEQCTQFGEVLAENGCI
                     LRIFNSTNIHMYDLEAADIANFKTHHNQPLPAPGGTFLVPAVSALLKSHNPEKCLMLFS
                     TGWMGFGGKLTSQMRIGMDPYFKEAATESHQRWVLHQSNNCNQNEEKQESFQKNGARAS
                     QNKTTLFQPTQQPTDGEEVKREYQVINRPN"
     misc_feature    complement(5053..5073)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 27.51"
                     /tool="antismash"
     gene            complement(6124..7038)
                     /gene="secF"
                     /locus_tag="CBUD_RS06190"
                     /old_locus_tag="CBUD_1238"
                     /old_locus_tag="COXBU7E912_1238"
     CDS             complement(6124..7038)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820140.1"
                     /locus_tag="CBUD_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1238"
                     /old_locus_tag="COXBU7E912_1238"
                     /product="protein translocase subunit SecF"
                     /protein_id="WP_011996989.1"
                     /transl_table=11
                     /translation="MEFFKANTKIPFMRQRKWAGIFSAIIFLASIITLAVNGLNLGLDF
                     TGGTQVEVNFTKPVDTNQIRKNLAEAGFPQAVVRVYDVRHISVRVAPHKELTQEELKEK
                     LMSAMPGGHIGSLDYIGPQVGKQLMTNGILAVIVALIATMIYIALRFEMRFALSAAIAL
                     IHDPVLILGIFSFFHIEFNLIVLAAVLTVIGYSLNDTIVVYDRIRENFRKVRRGTPTEI
                     VDLSINQTLSRTIMTSGLTLIVVLALFIFGGSTLRPFALALIIGIVIGTYSSIYVAGSL
                     AVTFGLSRRHLIRSPKKIEDDLP"
     gene            complement(7038..8906)
                     /gene="secD"
                     /locus_tag="CBUD_RS06195"
                     /old_locus_tag="CBUD_1240"
                     /old_locus_tag="COXBU7E912_1240"
     CDS             complement(7038..8906)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820141.1"
                     /locus_tag="CBUD_RS06195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1240"
                     /old_locus_tag="COXBU7E912_1240"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_011996990.1"
                     /transl_table=11
                     /translation="MNRYPLWRYILLAVLIIISLIYALPNLYGEDPAIQISAKNSAPIE
                     AVEEKIKSTLNAQHISYLSVRPVDNTVLVRFPSTEDQLKAQDVIQAVVGTDYSVALNLA
                     PRTPRWLQAIGAKPMRLGLDLRGGIHFLLDVDVGAMVKAQETGDLHTMSTALREARIRY
                     TEMSSDQNGVMIHFRDQAARDQARTLLEKQFPDYRFEATASSLRGTISITALHQIQQNA
                     VDQITTILRNRVNELGVAEPVIQQQGESQISVDLPGIQDTARAKDIIGKVATIRLQLVD
                     VEHDAETASSTGTVPFGSKLYTFEKQPVLLKQQVVLKGTSIINASSVIGEDGRPAVRVR
                     VSGSDVPSFNRITGENVGKPLAVVYVETQTTRHLVDGKVVTQHRQIERIINIATIQTAL
                     GNDFQITNLSTMDYAKNLALLLRSGAYPVPVDFVQERVVGPSLGQENIHMGVLSTEIGA
                     LLVIVFMAFYYRLFGVIADIALALNIVFIVAVLSILGATLTLPGIAGIVLTVGMAVDAN
                     VLINERIREELRNGMSTQASIKAGYDRAFATIVDANVTTLIVMIILFALGSGPVQGFAV
                     TTTIGLLSSMVTAIFFTRAVVNLVYGRRRASRLSIGINAKSAEAKK"
     gene            complement(8922..9272)
                     /gene="yajC"
                     /locus_tag="CBUD_RS06200"
                     /old_locus_tag="CBUD_1241"
                     /old_locus_tag="COXBU7E912_1241"
     CDS             complement(8922..9272)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820142.1"
                     /locus_tag="CBUD_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1241"
                     /old_locus_tag="COXBU7E912_1241"
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_005768440.1"
                     /transl_table=11
                     /translation="MSLLSVLGVGVAYAAPVTAQAPHPGGFWSMLWLPLLLILVFYFLL
                     IRPQTKRAKEHRQLLEGISLGDEVVTTGGVVARVSRLKDNFVVLEISKGTEITVQKASI
                     ASVLPKGTIDSI"
     gene            complement(9333..9773)
                     /locus_tag="CBUD_RS06205"
                     /old_locus_tag="CBUD_1241a"
     CDS             complement(9333..9773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012220529.1"
                     /locus_tag="CBUD_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1241a"
                     /product="mannan-binding lectin"
                     /protein_id="WP_012220529.1"
                     /transl_table=11
                     /translation="MKHLFLGISLLISSSFAFAFNPFSEPVGNYRQSCSACQVFNDQLS
                     CLCKDRQGIPHQTSLRLSPRCRFVENINGQLQCTRYRPRYPHHYRFVKDFPAGPIWNQA
                     DAQNKCPPVCASHGARWTGNWHTVREGRQSVCQCRGWSRWSR"
     gene            9838..10023
                     /locus_tag="CBUD_RS12240"
     CDS             9838..10023
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_002332975.1"
                     /locus_tag="CBUD_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_099115277.1"
                     /transl_table=11
                     /translation="MGFLLGAIKSVGFQPVARMSEAKYGKTMISSIVPVFRFAHTYILS
                     GSNGTRIYQSTKELVI"
     gene            complement(10001..12970)
                     /locus_tag="CBUD_RS06210"
                     /old_locus_tag="CBUD_1243"
                     /old_locus_tag="COXBU7E912_1243"
     CDS             complement(10001..12970)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011996991.1"
                     /locus_tag="CBUD_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1243"
                     /old_locus_tag="COXBU7E912_1243"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_011996991.1"
                     /sec_met_domain="DUF4135 (E-value: 4.7e-112, bitscore:
                     371.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.5e-63, bitscore:
                     211.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDIIEVIKASSPDATHQWKNLITALEKREKHLLALLSSLFAHAE
                     NFFLEIINETGSPLSQIITKQTLMDFIQRDLTNLLLPLISRVCIYEMYVVAENHKLQGE
                     TPEKRFDYFVSLLSDPKTALLLFEKYPLLKTLIDTVYQQYLENQTQLMQRLANDYKEIC
                     QFFFKKKIERPLFLTRITSAGDRHNQGRCVAILEFSNEKDNFKLVYKPRSLRIDQAFQQ
                     LIDWFNQKLSAQLYCPKILLKPEYGWCEFITYTECKNKKEVALFYQRLGILLGISHLLA
                     STDIHAENIIAHGSHPVFVDFECALRPLFKSDDQKPSPEVPPHLVSDTALLPARFMARE
                     DYNGIDLSGIFWPDEQEAPYRRMCWKKVGTDEMYLVREKSILPTQQNMPRLKHDHVDPL
                     SYEKDISSGFTRCYQLILDHKKELLSDHSPLNAFQNVPIRVLFRATVVYAKLLFESYHP
                     LLLYDNDKRRDHFLWLKEHAKPLIFSEEILDSEINDLLSNNIPYFSCQADKEQVFSPTH
                     QQIALQFRFSGLERVKQHLIHRFNKNDLRLQLLIIENSFMTLRLNRGLAYEKNIPVSDE
                     IPSSSRNIKDEAFMLAKKELDRLMDYAIIGDNRIMWPCIEMVGSDAWSPAFTDISLYKG
                     IAGISLVFAYAASLFESKPYERIARLGLNSLIEVFSEQKKEAIVSMGVGAFTGLGGLIY
                     ALSVFDQFIPDKRIRPMLEILFTWMDEFIEKDNILDVLSGSAGFIPLLLSAQSFINPKR
                     KIMLLKKVAKHILTQYPNPAKLFTGYKNPYANQPLLGASHGAAGFIWALVKANYFLHDK
                     NIEQWIKSALAYERSHFDYEKNNWPSFQKQNREHYRGDKFMTAWCHGAAGIGLTRLDSR
                     EFWQDDLIDEEIDRAIQTTLKEGFGLSTTLCHGDLGNLDFLLEASQKNPSKKLQDIFHT
                     HAVFVVERIKKHGISLDIRGTLPFPGLMLGVAGVAYQLMRVAEPQRLPSILLLKLPTLW
                     "
     CDS             complement(13036..13191)
                     /gene="allorf_1222817_1222972"
                     /locus_tag="allorf_1222817_1222972"
                     /protein_id="allorf_1222817_1222972"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIYNSFNEAGMVAIGNVEMPVDMMLGGPMTSVTEAHRANVAVTTC
                     VDRFCT"
     CDS_motif       complement(13147..13191)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIYNSFNEAGMVAIG"
                     /locus_tag="allorf_1222817_1222972_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13036..13146)
                     /prepeptide="core"
                     /locus_tag="allorf_1222817_1222972_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.70"
                     /molecular_weight="3776.4"
                     /monoisotopic_mass="3773.8"
                     /core_sequence="NVEMPVDMMLGGPMTSVTEAHRANVAVTTCVDRFCT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIYNSFNEAGMVAIG"
                     /leader_location="[13146:13191](-)"
                     /alternative_weights="3794.4"
                     /alternative_weights="3812.4"
                     /alternative_weights="3830.4"
                     /alternative_weights="3848.4"
     misc_feature    complement(13172..13185)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.39"
                     /tool="antismash"
     gene            13351..14439
                     /gene="mnmA"
                     /locus_tag="CBUD_RS06215"
                     /old_locus_tag="CBUD_1245"
                     /old_locus_tag="COXBU7E912_1245"
     CDS             13351..14439
                     /EC_number="2.8.1.13"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_043880902.1"
                     /locus_tag="CBUD_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1245"
                     /old_locus_tag="COXBU7E912_1245"
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="WP_043880902.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.7e-06, bitscore:
                     23.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNFEQNQVIAVGLSGGVDSSVAALVLKEKGYEVIGLFMQNWETD
                     SKDPFCTAEQDLSDAKAIADHIGIPLYVVNFSKAYWNHVFQHCLDEFAQGRTPNPDVWC
                     NREIKFKSLLDHAKKLGATHLATGHYACIQNENNEYRLLKSNDSHKDQSYFLHLLNQYQ
                     LANSVFPIGGYQKSEVRAIAKKRGFINHAKKDSTGICFIGERKFKDFLNEFLLAQPGNI
                     ETPEGKIIGKHDGIMFYTVGQRKGLHIGGRPDAGEAPWYVVDKDVKRNVLIVVQGYEHP
                     LLYSQELTCTNLHWIRDTEPSFPLTCKAKTRCRQADQTCVVTRLDNDHCHVQFEHPQRA
                     ITRGQSVVFYLGNECLGGGIIN"
     gene            14451..17924
                     /gene="mfd"
                     /locus_tag="CBUD_RS06220"
                     /old_locus_tag="CBUD_1246"
                     /old_locus_tag="COXBU7E912_1246"
     CDS             14451..17924
                     /EC_number="3.6.1.-"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="mfd"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820146.1"
                     /locus_tag="CBUD_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1246"
                     /old_locus_tag="COXBU7E912_1246"
                     /product="transcription-repair coupling factor"
                     /protein_id="WP_011996993.1"
                     /transl_table=11
                     /translation="MIKVEMTPISPLQPPIPRSIDNRLQWGNLKGDSVSLAISTLAEKN
                     QGPLLLITPDVHSANYLHRSLPFFSSADTPILHFPDWETLPYDYFSPHEDIISERLLTL
                     YRLPRLSSGIIISALPTLLQRLPPADHLEKNTFILSVGEKFSLQENRERLISAGYRSVQ
                     QVMEHGEYAQRGSIIDIYPMGSPLPYRIELFDDEVTSIRSFDPESQRSVEKIESVRLLP
                     AREYPLTKEAITHFRQSWRAKFLGNPQEAPIYQQISEGEAAAGIEYYLPLFFETTQTFF
                     SYLPKNTTVILFEKLETVAHQFWQEVEHRYEQLRHDLTRPLCPPSELFLSFEQLRIEIK
                     NHTQIKISDAPIIEKTGQVNFATENFPPLLIDHKASQPFARLKNFLHEITAIQGGRVLF
                     CAETAGRRETLLEFLKEIDTTPQAVKNWRTFLAENTRVGLTIAPLDKGVLLSSPPLAII
                     SESQLFGEQIRQRRLEKERKIDPNLLIRNLTELHIGDPVVHIQHGVGRYLGLQTIKTSD
                     QEAEYLTLQYADNDKIYVPVSSLYLISRYAGADASHAPLQKLGSKQWEKIKEKTQKHIR
                     DVAAELLDIYSRRQAATGFTFSIPEKEYSLFRQAFPFEETPDQSAAINDVIVDMSSKRS
                     MDRLICGDVGFGKTEVAMQAAFIAVQNNKQVAVLVPTTLLAEQHFYNFQDRFADWPVRI
                     AAISRLRTQKQRQQITQELAEGKIDIIIGTHKLLSKDIRFKDLGLLIVDEEHRFGVTQK
                     ERIKSLRAHVDILTLTATPIPRTLNMSLSGIRDLSLITTPPAKRLSVKTFVHDYSHVLI
                     REAILRENLRGGQVYFLHNDVATLAATAEKLRTIIPEARLAIAHGQMRERDLERVMSDF
                     YHQKYNLLVCTTIIESGIDIPTANTIIINRADRFGLAQLHQLRGRVGRSHHQAYAYLLI
                     PDQEALTADAEKRLSAISQLDDLGVGFNLATHDLEIRGAGELLGVEQSGQIHDIGFSLY
                     LELLEEAVSALKAGREPQFEKPLHAASEIDLGITTLLPEDYVPDVNARLILYKRLANCK
                     NKREIQALKEELIDRFGPLPPAAQHLLQSAELRLIANELGIQKINIGPKYGYFHFDKKP
                     AIDLTKLIKLIQTQPQRYQLQGDESLRFILSNPTPQSKLETIYELIKNLK"
     gene            18068..18727
                     /locus_tag="CBUD_RS06225"
                     /old_locus_tag="CBUD_1247"
                     /old_locus_tag="COXBU7E912_1247"
     CDS             18068..18727
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012220533.1"
                     /locus_tag="CBUD_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1247"
                     /old_locus_tag="COXBU7E912_1247"
                     /product="COXBURSA331_A1300 family Dot/Icm T4SS effector"
                     /protein_id="WP_011996994.1"
                     /transl_table=11
                     /translation="MRDIAHALMNVLRMEDNPIHSLRLNVVEIPGNRILLNLRQEAPIL
                     SSQAFQWLVELYNPPFNPYPVAHIIRIRIFLTYSILKNCTENTRLKERYATSLENEIIN
                     KDRMGRGYLLTLFELYGILTIDQYPKDAEGWIMIDNEPISCRIPDIELFLKDLQFLRSQ
                     NRREVKPIDSCLPSDLLKIIDNYSEREGPFTLFHQRQLIPHQQCNLEEKKPNDSLS"
     gene            complement(18773..19510)
                     /locus_tag="CBUD_RS06230"
                     /old_locus_tag="CBUD_1248"
                     /old_locus_tag="COXBU7E912_1248"
     CDS             complement(18773..19510)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820149.2"
                     /locus_tag="CBUD_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1248"
                     /old_locus_tag="COXBU7E912_1248"
                     /product="HAD family hydrolase"
                     /protein_id="WP_011996995.1"
                     /sec_met_domain="HAD_2 (E-value: 2.7e-32, bitscore: 109.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDGFIAVASIDLDMVYWPVAYLLICKMKDVKYLLFDLDGTLTD
                     PKEGITRSVQYALEQMNVACPSMDELEWTIGPPLIDAFALLLNTKDKKQLQKAIDFYRE
                     RYVDRCAIENKPYDGIHETLETLVNHGYQLYLATSKPWAYAGKILDHFNLRDYFTAVHG
                     SELDGTRDYKEELIGYVLDTQKISNTQSLMIGDRRYDILGAKHNNVRSIGVTYGYGSLE
                     EIQEAGPDAVCDHHRLILPTLNK"
     gene            19650..21041
                     /locus_tag="CBUD_RS06235"
                     /old_locus_tag="CBUD_1249"
                     /old_locus_tag="COXBU7E912_1249"
     CDS             19650..21041
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_820150.1"
                     /locus_tag="CBUD_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1249"
                     /old_locus_tag="COXBU7E912_1249"
                     /product="anthranilate synthase component I family protein"
                     /protein_id="WP_080512921.1"
                     /transl_table=11
                     /translation="MLTPTQAFYQLLDLYPTAILLEFSPRNEKPYAFIGFNPLAQIIAR
                     GDEITVFLKNTVTKMKGDPFHHLRRLCQQINCIDNHPLTKLTGAAIGYLSYDAIRYVES
                     IPDRHTASEKIADIDFKFYRDGITFDLESNNAIVSHIVEVKDELKHCYEYGLEKLADIT
                     NNLFTPARPKLSTNRKTHYSKSTSLDFKPDNNDTDFKKIVNKAKQYIAAGDIFQVVSSR
                     TFKKPYQGKPFDIYRALKKVSPSPYHFYLQNDSLAIAGASPEKMVSVKNGIIDSVPLAG
                     TRPRGNGKSDQTLAQELINDPKETAEHLMLVDLARNDIGIVSQAGSVEVAELMQPVNFS
                     HVMHLASRVQGSLAKNYDAIDVLKATFPAGTLSGAPKIRAMEIIDELEHSRRGLYGGAI
                     VALDRDDNLDTCIIIRTTIVENGIASIRAGAGIVHDSDPIAEANETRHKAKSVMAAIQL
                     AEGGL"
     misc_feature    complement(19682..19700)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.39"
                     /tool="antismash"
     gene            21095..21679
                     /locus_tag="CBUD_RS06240"
                     /old_locus_tag="CBUD_1249a"
     CDS             21095..21679
                     /EC_number="4.1.3.27"
                     /GO_function="GO:0004049 - anthranilate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046820 - 4-amino-4-deoxychorismate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00566.1"
                     /locus_tag="CBUD_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1249a"
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="WP_259431110.1"
                     /transl_table=11
                     /translation="MATHYSDVCVFRNDKITIAQIAKLPIQGIILSPGPGRPENAGICI
                     EVVKKFAPQFPILGVCLGHQAIAVAFGAKVINADEIAHGKMTTIYHDDDPLFKKIPSPF
                     KGGRYHSLIVDKKTLTSDLLLIAENRDGIVMGIKHKVYPCYGIQFHPESILTPEGDRCL
                     INFLKSTFLQKQVFRRSMTTIPPAEFSLSLE"
     gene            21688..22689
                     /gene="trpD"
                     /locus_tag="CBUD_RS06245"
                     /old_locus_tag="CBUD_1251"
                     /old_locus_tag="COXBU7E912_1251"
     CDS             21688..22689
                     /EC_number="2.4.2.18"
                     /GO_function="GO:0004048 - anthranilate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpD"
                     /inference="COORDINATES: protein motif:HMM:TIGR01245.1"
                     /locus_tag="CBUD_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CBUD_1251"
                     /old_locus_tag="COXBU7E912_1251"
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="WP_043880903.1"
                     /transl_table=11
                     /translation="MLTTYLNQLMQKKDLTEVQCRSAIFEIINGAPSEQIAAFLALLHN
                     KSETADELYGIVSAMQNQMLSLPFNETVLDIVGTGGDNANTINISTAASLVVASYGIKV
                     AKHGNRAVSSQCGTADFLDSLNIPIRLTPQEAKNFLNERGFVFLYAPDYHPAMKLIKET
                     RKILGIRTTFNLLGPLLNPACPTHLIAGVADKRLLPIYSDVLLRSNVKRALIVHGNGLD
                     EINCLGPVEVIEIYNNKKKYYQLDPNDYNLNYCSLSDIQGGDSLLNKKLILTAFSGKES
                     AISDTIIFNAGVAFYLMNVIFSIQEGINLARRLIKNGTVINYIEKLRVVSYA"
ORIGIN
        1 tggtaaaagt taatcgattt tgaaatgtct gctggaacgc tgataccaaa ttcataaaat
       61 cgagctagcg ctaattgtgc ttctacgctt ccctctttag cggctttttc atagtacaat
      121 cgagctttat taagatcgat tttttgcgca acgcctgact cgctcatcaa acctaattga
      181 taagtcgcaa atgaattatt tttttgcgcc gcttggctat acatttttaa tgcggtgtta
      241 ggatcaaaac caatgcccgt tccctttaga tacattcctg caacctgaac cgccgccaaa
      301 tcgagcccgt tttgggccgc gtctttgtat aagcggaaag ctttttgtgg atcactttta
      361 actccttttc catactcata cattaaaccc agattataga gcgcttgagg gttatgaaac
      421 ttagaagcta aggtatacca ctttttagcc tctggataat tatgtttgct catttcataa
      481 ataaagccaa gtcctacttt agcgggcacg taattttggg cagccgattt ttttaaccaa
      541 tcgatggcct tgttaacatc gcgatcaacg ccccgaccca aatagtacat gtttcctaat
      601 aaatattgag cgatgggatt cccttgttca gccgactttt ggtaccactc ttctgcttta
      661 tggtaatctt tcggaaaaag aagaccatgc tcattcataa atcctaattt taactccgct
      721 gctggatctt gtttattagc taattcttgg taaatagcga cagctttttt ttctgatccg
      781 ggaactgggg tgtctaaaag ataataatcc gccaaaatct cttttatttt atcgtaatgg
      841 ttagcggctc taatcagtaa cgataaaaag ttttctcccg gcttggtgta tttattttgt
      901 ttcgctaaaa tagctaaatt atactgcgca taaccgtttc cttgattagc tgacttttct
      961 aaaagactga ttgctatatt ctcttttcgc ttgtttttaa ggtaataatt acctaacata
     1021 aattgtgcaa tagcattgtt ttgttttgaa agtttttcta aaatttccgc tgattttcgg
     1081 ctgttgctat taactccgaa accacgatca tataaaatag ctaataacat agcggcttct
     1141 ggatcattcg tttgataagc tttttgtgct atctcaaacg ttttctctgc caaagtggtc
     1201 tgattttgtt gcaaataaaa ataacctaga gccacatcag ctttctctag gccacttttt
     1261 gctgcttttt ggtaaagtgc ataggctttt ttccaatttt gtgtttctaa agaaacatta
     1321 ttatcgggat ttagaaaacc gctgacataa agttctgcta aacgatacgc agcaataggt
     1381 aagtttccac ccacagctaa gctgtacata gctttcgccc tatcaaagtt cttgaaaaga
     1441 attttattat tgctagcttt aatgcctcgc tcataaatgt tgcctaggac aaattgagct
     1501 tgtaaactgc ctttcagagc agcccttata aaccaactga tggctttctc ataatcttga
     1561 ggaacccctt tcccttgtaa ataataagtt ccaatagcgt attgggcttt taaataattt
     1621 tgttccgccg ctttcatata caattgaaat gcagtttcag ggtctttttg aacacctaat
     1681 ccattctcat acatttgccc caatctaaag agtgattgag cataaccgta attggccact
     1741 cgggagaggg attgaaaagc ctctttgtag ttattagctc caggcggcat tttaaaagga
     1801 taagcaggga cggttagatc aaatttttct tctttataat ttaattgtgt catgtaagat
     1861 agaatttttt cgggcggaat gtctttagaa tttgctaaat ttaaatttaa tttaattata
     1921 gaatttttat ctaaggccat ggatttcggc gttttagtaa aattgttgat agacgcagtg
     1981 actgtaatgg ggttgtttaa ctgaacgcct gctttttgca tgagtccaac catgatttgc
     2041 caaggcgtgg gctcagaacg attctcacta ttcgccttgg catcgctggt attaattcga
     2101 ttaattttat ccaatgtttt gcttgcttct ttacttccgt tagcagccgc tttttccaac
     2161 cattcaaccc ctttgacagg atctttttct gcttcatttc cagtatatag cattgtaccc
     2221 agtaaatact gagcatctgg atagttatat ttatcagccg ctttggttaa ccaaattctt
     2281 cccattcgtc tatcgccagc gtgcctgctg gctaagaaaa ttttggctag ctcatattga
     2341 cccattggaa tttcgttttg agcggctcca atgaaatatt ttctagcaat atcaatattt
     2401 tttttaacac cgtatccatt caaataacta attccagtaa aaagttgcgc accagcatcc
     2461 ccagcatccg ctgctttttt aaaccaaggc acggcctttt ccaaatcttt ctgctgttga
     2521 aaataataat tccccagata taattgggcc ggcaaatatt ttaattctgc cgcgcgcgtc
     2581 atataatcaa atcctttctc aaaatctctc cgaactccaa aaccattcat atacatggtg
     2641 gccaaataaa atgtcgcttc cccattattt ttttccgcta attgttttaa gccagtttcg
     2701 gccgcgcgat agttgccttc gtaatactcc tggaagacag ggtttttatc agaataacta
     2761 attgaaaaaa aacttaacgt taagataaaa acagctattc gtttcatagc agcgatcctt
     2821 cattttcaag atctcttttt ttcgggtcaa taagcaaaat tccgtaccaa cgtattgcgc
     2881 taacagccgc agttgaagag ccaatatttt ctacggccca ataatttcca cgattattat
     2941 cgccaaaacg tgtacgcgga aactcacaaa tatctagtac tttgctacag ttaattattt
     3001 taagttttaa aatatcattt ccaccattgg tacaaatata tttaactttt ttctcatccg
     3061 tggctaagac agaccaggca ttaggcgcta tggtggtatt gatatggata atataaggct
     3121 cgtcattgga cctagcttga aacaagctaa tcgcttgttt tgaaacattg tggatgaaat
     3181 aaatcgtttg tggatgatat ctacctgtag gctgcaatat aagattgtaa taattaaact
     3241 tatatcccat cggataacag ccgtaaggat atcttagtat ttttccttcg gcgcccggaa
     3301 ttaaaaaata aagagccgcc cctaaaagga caagaaactt tttacaaccc ttttccattt
     3361 ttacctccca ctattctcca atggtgagtt tctctacgac cacttttgtc cctaaatggc
     3421 cgtctttagt agccacattt acaaaattct cgtttaacca tttagcatct cgtttgaata
     3481 atcgcacgca accgtggcta tcccgataac cggtaacttc attagaaccg tgaagcgcgt
     3541 atcccttaaa aaagaacata caataaggca taacagctcc gccactcgtc tcgacaggga
     3601 atacattgga tttacacccc ggtcccttct tatgaaaaac ataaaagata cctgtgatcg
     3661 tttcacacga acggtttaca tcgcgacaat aattcttacc cgaggaaata gggccccatt
     3721 taatcaattg accttctgga tcataagcac cccaagccaa ttgatcttgg ttaaccataa
     3781 ttaatttttc gccaagcttt ttaattctca atgggaaagg agaaatactg taaattgtgg
     3841 cgtcctttaa atctttgggg accgctaagg ttttacctgg atataaataa gtatccgtgc
     3901 gattaagcct ttgaactaaa tcacgctggt tttcatcggg gaacaggttc tgccaactct
     3961 gacctcgctg tactttgata cattcaaaac ccgattttcc gcacaaaccc gtgccgtaat
     4021 attcattggg gctatctgcc ccaaatgcga tagaagcacc caacaatgag actaaaacta
     4081 tgaagatcgc cctttccatg gccttcaccc attaattttt actaattaaa atatagtcaa
     4141 gctaaaaaaa ctttccaatc caactagagg agattgttgc cctgcgtcct tgcgcggtgg
     4201 cgtcccagct tgtccgcggc ctagaaagcc ccacgtgcca tgtctcccgc gctcaagcct
     4261 gccggggctc gatctgggcc cttccaatta gtcttaagtt tttgttgaca agaaagattt
     4321 ttagccaaag ttctgaacct caaatgctgc aattgcctag ccaccctgat aagggtagct
     4381 agggctttct acatctaacc gtgagtacaa acaggcacac cgcaaagagc cgccgaactc
     4441 gacgcaacct ttgctatttt gtttgcaaca atcttctgaa tgaattgcat tttcataaca
     4501 attacctctt taaaaagtaa aaattcaagc aaagccagta ttatcaacag atgaactctg
     4561 gcttaactac ctatttaatg aaacaaatta ttgaggatca atatagtttg gctgcgtgct
     4621 agcagccgag taattggaga gatagaaaga tcaaagatgt ttgaatgacg ggtgatttaa
     4681 agtacgcttt tgccaatcgc ttaaagctct ccgtttctgt cgtccctttt gggggtggca
     4741 tcggtaattt cctcaacacc tcagcatcat cgggattgtt ttgccgctga atgaggtaat
     4801 tattcgtgtt attcagacct gccccaagag cgcctcatcg ccttttcgca ggatatcgga
     4861 gagcgactgt gtggagagaa cggcatggac atccgcaagg tgctatttat ttccgattaa
     4921 tttttggccc gattgccgta aatttagtct tttttttgat caaaaatagt gtagcattgt
     4981 cagtctagca ataatttctt ggagatatag ccctatgagt cgtgatccga aatcaaatcc
     5041 ccaataccca ataacagagc cagagctatc actgttagaa aaacagctct ctgagcaatt
     5101 ccctctccct caaaaatcta gtggttttga tccgttccca ttttcaaatg aagaagaagt
     5161 agataagaca atagataagc ttgaaaaatt agagccattc gataatgaaa aaataaatgt
     5221 cgcagtatgc tttggggaaa gctatttcct ctctttactc ccaacattac agaagctgaa
     5281 cataaaagtc gtaataatgg ctgatattga atcacggcta caccagcata ccagacattt
     5341 attaaacagc ctacttgaaa atgacacaag aaaaggcttc tttaaatcct atggaacaaa
     5401 aaatccagca gtgggttggg aagaagctgc aagtggattt ggtggaccaa gattattaga
     5461 taacctatct ttaatcaagc aattatgttt agacacgcca tcctatttag gtcaatacca
     5521 tttctgtgct ctcgatggtg agaaagagac tgccgacaag cgatatcagg tttgtcggaa
     5581 agctgctcaa agcttgaagg ttgttcaagt tgggttgaac ttattcaata ttgagcaatg
     5641 cacccaattt ggagaggtcc tcgcagagaa tggctgcata ttgcggatat ttaattccac
     5701 taatattcat atgtatgatc tggaagcggc tgacatcgct aattttaaaa cacatcataa
     5761 ccaaccacta ccagcaccag ggggaacttt cctggttcct gctgtaagcg ctttattaaa
     5821 gtctcataac cccgaaaaat gtctaatgct attctcaacg ggatggatgg gttttggagg
     5881 taaattgaca agtcaaatga gaattgggat ggatccttat tttaaagaag ctgccactga
     5941 gtctcaccag cggtgggttc ttcaccaatc taacaactgc aaccaaaacg aggaaaaaca
     6001 ggaaagtttc cagaaaaatg gtgcccgtgc atcacaaaat aagacaacgt tatttcagcc
     6061 tacccaacag ccaactgatg gggaggaggt aaagagggaa tatcaagtaa tcaaccgtcc
     6121 caattaaggc aaatcatcct caattttttt aggcgaacga ataaggtgcc gacggcttag
     6181 gccaaaggtc accgccaagg accccgcaac gtaaatggat gaataagtcc caataacaat
     6241 gccaatgatt aaagccaacg caaaaggccg cagagtggag ccaccgaaaa taaataaagc
     6301 gagcacgaca atcaacgtta acccagaagt cataatagtc cgagaaagcg tttgattaat
     6361 cgaaagatcc acaatctcag tgggagtccc acgacgaacc ttacggaaat tttcacgaat
     6421 acggtcataa acaacgatag tatcgttaag tgaataacca ataaccgtca acacagccgc
     6481 caacacaatc aagttaaatt cgatatggaa aaaagaaaaa atacctaaaa tcaaaaccgg
     6541 atcgtggatt aaggcgattg cggcactcaa cgcaaatcgc atctcgaatc gaagggcgat
     6601 ataaatcatc gtagcaatca acgccacaat caccgccaaa ataccgttag tcatcaactg
     6661 cttgcccact tgaggaccga tataatcgag cgaaccaatg tgccctcccg gcattgcaga
     6721 cattaatttt tcttttaatt cctcctgggt taattcttta tgcggagcca cccgaacaga
     6781 aatgtgacga acatcgtaaa cgcgaacaac tgcttgagga aagcccgcct ctgccaagtt
     6841 tttccgaatt tggttcgtat cgacaggctt tgtaaaatta acttctactt gtgtaccacc
     6901 ggtaaaatca agacctaaat tcaatccatt aacagccaac gtaataatag aagccagaaa
     6961 aataatagct gaaaaaattc ccgcccactt acgttggcgc atgaatggaa tcttagtgtt
     7021 ggccttaaaa aattccatta cttcttagcc tctgcggatt ttgcgttaat cccaatagac
     7081 aaacgtgaag ctctgcgccg tccgtacact aaattcacca ccgcccgtgt aaagaaaatc
     7141 gctgtcacca tcgacgacaa caaaccaata gtcgtcgtca cagcaaagcc ttggactggc
     7201 cccgagccta aagcaaataa gataatcatt acaatcagcg tggtcacatt ggcatccaca
     7261 atggtagcaa aagcccgatc gtatccagct ttgatactcg cttgcgtcga catcccattg
     7321 cgcaactctt ctcgtattcg ctcgttaatt aacacattcg catcgacagc catccccact
     7381 gttaacacaa tacccgcaat accgggcaaa gtgagggtag cacccaaaat ggataacacc
     7441 gcaacaataa agacgatatt caaagctaac gcgatgtcag caatgacgcc gaacagccga
     7501 tagtagaacg ccataaacac aatcaccaat aaagcgccaa tttcggtaga taaaaccccc
     7561 atgtggatat tttcttggcc caaactcggg cccaccactc gttcttgcac aaaatcaacg
     7621 gggacaggat aagcgccaga gcgtaataac aaggctaaat tttttgcgta atccatcgta
     7681 gataagttag ttatttggaa atcatttcca agagcagttt gaatcgtcgc tatattaata
     7741 atacgctcaa tttggcggtg ttgagtcacc acctttccat cgactaaatg acgcgtagtt
     7801 tgagtttcta cgtaaacaac ggctaaaggt ttgccgacgt tttcccccgt aattcgatta
     7861 aaagaaggca catcgctgcc actcacccga actcgcaccg ctgggcggcc atcttctcca
     7921 ataacactcg aggcgttaat aatcgaagtt ccttttaaca cgacctgctg cttcaatagt
     7981 acgggctgct tttcgaaggt atataatttt gaaccaaaag gcacagtccc cgtgctcgag
     8041 gctgtttcag catcgtgttc aacatccacc aattgcaaac gaatggtcgc tactttacca
     8101 ataatatctt tggctcgagc cgtgtcttga atgccaggca aatcaacgct gatttggctt
     8161 tctccttgct gttggataac cggttccgca acgcctaact cattaacacg gtttctgagg
     8221 atcgttgtta tttgatccac ggcattttgc tggatttggt gcaatgccgt tattgaaata
     8281 gtgcctcgaa gactcgatgc cgtggcttca aaacggtagt caggaaattg tttttccaag
     8341 agcgtgcgcg cctgatcacg ggctgcttgg tcacggaaat ggatcattac gccattttgg
     8401 tcgcttgaca tctctgtata gcgaatgcgg gcttcgcgaa gcgccgttga catggtatgt
     8461 aaatcgcccg tttcctgggc tttcaccatg gcgccaacat ccacatctaa taagaaatgg
     8521 ataccgccgc gcaggtccaa tcctaagcgc atcggttttg cgccgatcgc ctgtaaccat
     8581 cggggcgtcc gcggcgctaa attcaatgca acggaataat cagtaccaac gacagcctga
     8641 atcacatcct gcgctttaag ctgatcttcg gtactgggaa agcgaaccaa aacggtatta
     8701 tcgacaggcc gaaccgaaag ataagaaata tgttgagcgt ttaaggttga tttgattttt
     8761 tcttcaacag cctcaatggg agcactattc ttagctgaga tttgaatagc cggatcttcc
     8821 ccatacaagt taggtaacgc ataaatcaaa ctgatgatga tgagtacggc gagtaatata
     8881 taacgccaca acggatatcg attcatgcat taccctaact gttaaatcga atcgatcgtg
     8941 cctttgggca atacagaggc tatagaagct ttctgtacag tgatttcggt acctttgcta
     9001 atttcaagga caacaaaatt gtctttcaat cgcgataccc ttgcaacaac gccccctgtc
     9061 gtcaccacct cgtcacctaa agaaatacct tccagcaatt gtcgatgttc tttagctcgc
     9121 ttggtttgag gacgaattaa cagaaaataa aacaccagaa ttaacaggag cggcaaccac
     9181 agcatggacc aaaaaccgcc cggatgcggc gcttgagctg tgactggtgc agcataagcg
     9241 acccctacgc ctaatacact caatagactc ataatgttac tcctcttaaa aaaacgactt
     9301 aatgtaccgt gttcaagtca aagacgcaaa ttttaacggg accagcgcga ccaacctcgg
     9361 cattgacaga ccgactgacg gccttcgcgc acggtgtgcc aattgcccgt ccaacgagcg
     9421 ccgtggcttg cgcaaaccgg cgggcatttg ttttgtgcat ctgcttggtt ccaaatcggc
     9481 cccgccggaa aatctttaac aaaccgataa tggtgagggt agcgaggtct ataacgcgtg
     9541 cattgtaatt gaccgttgat attttccaca aaacggcagc gaggagagag acgaaggctc
     9601 gtctgatgag gaatcccttg ccggtctttg caaagacaag aaagttgatc attaaacacc
     9661 tgacaagcac tgcaagactg acggtaattg cccaccggtt ccgaaaaagg attaaatgca
     9721 aacgcaaaag aagaagaaat taataaagaa attcctaaaa atagatgctt cataacaaat
     9781 ccgccttctc agtaataacc gggatatgct aacacacttt tcccaatctc gtcattcatg
     9841 ggattcctgc tgggtgcgat taaaagtgta ggttttcaac cagtagcccg tatgagcgaa
     9901 gcgaaatacg ggaaaacaat gatctcatct atcgtccccg tatttcgctt cgctcatacg
     9961 tatatactat ctggcagtaa cggcacgcga atttaccaat ctaccaaaga gttggtaatt
    10021 taagcagtag aatggaaggt aagcgttgag gttcagcaac tcgcattagc tgataagcaa
    10081 caccagcgac ccctagcatg agcccaggga atggcagtgt gcctctaatg tctaaagaaa
    10141 taccatgctt tttaatgcgc tctacgacaa agacggcgtg tgtgtgaaaa atgtcctgta
    10201 actttttcga tggatttttt tggctggctt ctaacaaaaa gtcgagattc ccaaggtcac
    10261 catgacaaag ggtcgtgctc aaaccgaagc cttcttttaa agtagtctgt attgccctat
    10321 caatctcttc atcaattaaa tcatcttgcc aaaattctcg actatctaac cgggttaaac
    10381 caatgccagc tgctccgtga caccatgctg tcataaattt atcccctcga taatgctctc
    10441 gattctgctt ttggaagctc ggccaattat ttttttcata atcgaagtgg ctgcgttcgt
    10501 aagcaagcgc gctttttatc cattgctcaa tatttttgtc atgcaaaaaa taattggctt
    10561 tcactaaagc ccatataaat cccgccgcac catgtgaggc acctagcagc ggctgattcg
    10621 cgtatggatt tttatatccc gtaaataatt tggcagggtt tgggtattga gtaagaatat
    10681 gctttgccac ttttttaagc agcattatct tccttttggg attaataaag ctctgtgctg
    10741 ataaaagcaa tggaataaaa ccggctgaac cgctcaagac atccaagata ttgtctttct
    10801 caataaactc atccatccat gtaaatagta tttctagcat tgggcgaata cgtttgtccg
    10861 gtatgaactg atcgaaaacc gacagtgcat agatcaagcc gcccaaccct gtaaaagcac
    10921 ccacacccat actaacaatc gcttcctttt tttgctctga aaatacctca atcaaactat
    10981 ttaagcctaa tcgagcaatc ctttcatagg gtttactttc aaaaagagaa gctgcgtatg
    11041 caaagacaag ggaaattcct gcaattcctt tatagagact aatgtcggta aaggcaggtg
    11101 accatgcgtc ggagccaacc atttcaatac aaggccacat aattcgattg tcaccaataa
    11161 ttgcataatc cattaatcgg tcgagttctt ttttggctag catgaaagct tcatctttta
    11221 tatttctgct ggatgaaggt atctcatcgg aaacaggaat gtttttttcg taagccaaac
    11281 ctcgatttaa ccgtaatgtc ataaaactat tttcgataat gagcaattgt aatcgcaaat
    11341 catttttgtt gaaacggtgg atcaaatgct gctttacgcg ctctaatcct gagaaacgaa
    11401 attgtaaagc aatctgctgg tgagtagggc taaaaacttg ttctttatca gcctgacatg
    11461 aaaaataggg aatattgtta gataataaat cgttaatttc ggaatccagt atctcttcag
    11521 aaaaaatcag cggttttgca tgttctttta gccacaagaa atgatctcgg cgcttgtcgt
    11581 tatcataaag caacaaaggg tgataacttt cgaataaaag cttcgcataa acaaccgttg
    11641 cccgaaataa gacgcgaatg ggaacatttt gaaaagcatt cagcggcgaa tgatccgata
    11701 ataattcttt tttatgatca agaattaatt gataacagcg ggtaaaacca ctgctgatat
    11761 ctttttcata agataaaggg tccacgtgat cgtgctttaa tcgcggcatg ttttgctgag
    11821 tcggcagaat gcttttttca cgtactaaat acatctcgtc tgttcctact tttttccagc
    11881 acatgcgccg ataaggcgct tcttgttcat cgggccaaaa aatgccgctt aaatcaatac
    11941 cgttatagtc ttctcgcgcc ataaatctgg caggcaaaag cgcggtatca ctaaccaaat
    12001 ggggtggcac ttctggcgat ggtttttgat catcgctctt aaagagggga cgtaacgcgc
    12061 attcaaaatc aacaaagacg ggatgagaac catgtgcgat gatgttttca gcatgaatat
    12121 ccgtggaagc taataagtga ctgatgccta acaaaatgcc caaacgctga taaaacaagg
    12181 ctacttcttt tttgttttta cactcagtgt aagtaataaa ttcgcaccat ccgtattccg
    12241 gtttaaggag tattttcggg caatacaatt gcgccgataa tttttgattg aaccaatcta
    12301 tcagttgttg aaaggcctga tcaatgcgaa gcgagcgggg tttataaacg agtttaaagt
    12361 tgtctttttc attagaaaat tccaaaatgg caacgcaacg cccttggtta tgtctatccc
    12421 ctgcagaagt gatgcgagtt aagaataacg ggcgttcaat ttttttctta aaaaagaact
    12481 ggcaaatttc tttgtaatca tttgccagcc tttgcatcaa ttgcgtttgg ttttctaaat
    12541 attgttgata aacggtgtca atcagtgtct ttaaaagagg atatttctca aaaagcaata
    12601 aggcagtttt tggatcactc aagagagata caaaataatc aaaccgtttt tcaggagtct
    12661 ctccttgaag tttgtgattt tcagccacga catacatctc ataaatacaa acacggctga
    12721 tcagcggtaa cagtaagtta gttaagtccc gctggataaa gtccatcaag gtttgtttag
    12781 tgatgatttg gctaagcggc gagcctgttt cgttgataat ttctaaaaag aagttttctg
    12841 catgtgcaaa taatgaagat aataacgcta ataaatgttt ttctcgtttt tctaacgcag
    12901 taatcaaatt tttccattga tgagtagcat ctggcgaact agccttgatt acttcgataa
    12961 tgtcgatcat tccgtttctt caaaaaaaag caggcagatc cgattcgagg attttgcctg
    13021 ctttgtttac gtagattacg tacaaaatct atcaacacaa gtcgttactg caacattggc
    13081 acgatgggcc tctgttaccg acgtcattgg tcctcccagc atcatatcta ctggcatctc
    13141 cacgtttcca atggcaacca ttcccgcttc attaaaagaa ttataaatca tataatatag
    13201 ccctcatatt tcatacttaa tcactttgtt taacgctgct atcgttaaga aatagctcac
    13261 ataataacca gaattatagc aaaattattc tctaaagaca aaggaacggg ccacccttga
    13321 cttttgggga tcatcttcta cactacccag atgccaaatt ttgaacaaaa tcaagtgatt
    13381 gccgttgggc tgtctggcgg ggttgattcg tcagtggctg cgctcgtctt gaaggaaaag
    13441 ggttacgaag tcattggtct tttcatgcaa aattgggaaa ctgatagcaa agatcctttc
    13501 tgcaccgccg aacaagattt aagtgatgcg aaagcaatcg ccgatcacat tggtattccg
    13561 ttatacgtcg tgaatttcag taaagcctat tggaaccatg tttttcaaca ttgcctcgat
    13621 gaattcgccc aagggcgaac ccctaacccg gacgtttggt gtaatcggga aattaaattt
    13681 aaatcacttt tagaccatgc taaaaaactg ggcgccactc atctcgctac cggccattac
    13741 gcttgcatcc aaaatgaaaa taacgaatat cgactattaa aaagcaacga tagccacaaa
    13801 gatcaaagtt attttttaca ccttcttaac caataccaat tggcgaatag cgtatttccc
    13861 atcggcgggt atcaaaaatc tgaagttcgt gcgatagcaa aaaaaagagg attcattaac
    13921 catgctaaaa aagacagcac ggggatctgt ttcatcggcg aacgcaaatt taaagacttc
    13981 ctcaatgaat tcttactcgc ccaaccggga aatatcgaaa cacccgaggg gaaaattatc
    14041 ggcaaacacg acggaattat gttttatacc gttggtcaac gcaaagggct tcatatcggc
    14101 ggtcgaccag acgcgggtga agctccctgg tatgtcgttg acaaagatgt aaaacggaat
    14161 gtattgatcg tggttcaagg gtatgagcat cctttgcttt attcacaaga attaacgtgc
    14221 acaaatttgc attggatacg cgacacagaa ccctctttcc ccttgacctg caaggctaaa
    14281 acgcgttgcc gtcaagccga tcaaacgtgc gtcgtcacgc gactcgataa tgatcattgt
    14341 cacgttcaat ttgaacatcc acaacgagca atcactcgcg gccaatcggt ggtattttac
    14401 ctgggaaacg aatgccttgg cggcggaatt attaattaag gacccgttaa ttgattaaag
    14461 ttgaaatgac tccgataagc cctttacaac ctcccattcc tcgctccatt gacaatcgac
    14521 tccaatgggg aaatttaaaa ggtgatagcg tcagccttgc aatcagcact cttgcggaaa
    14581 aaaatcaggg gcctttgtta ttaatcacac cggatgttca ctcggctaat tatttacacc
    14641 gttcattgcc atttttttct agcgccgaca cccctatctt acattttcct gactgggaaa
    14701 cattgccata cgattatttt tccccccacg aagatattat ttctgaacgc ttgctaacgc
    14761 tttaccgctt accgcgttta tcgtcaggaa ttatcatcag cgctcttccc accttattac
    14821 aacgccttcc tcccgccgat cacttagaaa aaaatacttt tattttatcc gtgggtgaaa
    14881 agttttcttt gcaagaaaat cgtgaacgtt taatatcggc gggttaccgt tccgttcaac
    14941 aagtgatgga acatggtgaa tatgctcaac gcgggtcgat catcgatatt taccccatgg
    15001 gaagcccact tccttaccga atcgaattat ttgacgatga agtaacaagc attcgcagct
    15061 ttgatcccga aagccagcga tccgtagaaa aaatagaatc ggttcggttg ttaccggcga
    15121 gagaataccc gttaacgaaa gaagccatta cgcattttcg acaatcgtgg cgtgcaaaat
    15181 tcttgggtaa cccgcaagag gctcctattt atcagcaaat cagtgaagga gaagcggcgg
    15241 ccggtattga atattattta ccgttgttct tcgaaaccac ccaaactttt ttttcctatt
    15301 tgccgaagaa taccaccgtt attttatttg aaaaactgga aaccgttgct catcagtttt
    15361 ggcaagaagt agaacatcgt tatgaacaat tacgccacga tttaacacga ccgctctgcc
    15421 cgccctcaga attgtttttg tcttttgagc aattaaggat agaaataaaa aatcatactc
    15481 aaataaaaat tagcgatgca cccatcattg aaaaaacagg gcaagttaac tttgctacgg
    15541 aaaatttccc tcctttatta attgatcata aagcttccca accgtttgct cgattaaaaa
    15601 actttttaca tgaaataacg gctattcaag gggggcgcgt tttattttgt gccgaaacag
    15661 ccggccgtcg agaaactctt ctagaattcc ttaaagaaat tgatacaact cctcaagccg
    15721 ttaaaaattg gcgaacgttt ttagcagaga atacgcgagt tggccttact atcgcgcctt
    15781 tggataaagg cgttttatta tccagcccgc ctttggccat tatttcagaa tcacaactct
    15841 tcggcgaaca aatccgccaa cgtcgcttgg aaaaagaacg aaaaattgat cccaatttat
    15901 tgattcgcaa tttaacagaa ttgcatattg gcgaccccgt ggttcacatc caacatggag
    15961 tcggccgtta tttgggcttg caaaccatta aaaccagcga tcaggaagct gaatatttaa
    16021 ctttacaata tgcggataat gacaaaattt atgtgccagt ttcttcgctg tatttaatca
    16081 gccgttatgc cggtgctgac gcttcccatg ctccccttca aaaactcggc agcaaacagt
    16141 gggaaaaaat caaagaaaaa acacaaaaac atatccgtga tgtggcggcc gaattattag
    16201 atatttacag ccgccgtcaa gcggcaacgg gttttacttt ttctatacct gaaaaagaat
    16261 actctctttt ccgccaagct tttccttttg aagaaacacc tgaccaaagt gccgccatta
    16321 atgacgttat tgtcgatatg tcttcaaaac gcagtatgga ccgcctcatt tgtggggatg
    16381 ttggttttgg aaaaaccgaa gtggcaatgc aagccgcttt tatagccgtg cagaataata
    16441 aacaagtcgc tgttttagtt ccaacgactt tattagccga acaacatttt tataattttc
    16501 aagatcgttt tgccgactgg ccggttcgta ttgccgctat ttctcgctta cgcacccaaa
    16561 aacaacgcca gcaaattacc caagaactgg ctgaagggaa aatagatatt attatcggca
    16621 ctcataaatt attaagcaaa gatatccgat ttaaagattt aggtttatta attgttgatg
    16681 aagaacaccg tttcggcgtt acccaaaaag aacgaattaa atccttacgc gcccatgtgg
    16741 atattctgac gctcacagcc acgccgatcc ctcgaacatt gaatatgtcg ctttcaggta
    16801 ttcgcgactt gtcccttatt acaaccccgc cggcgaaacg cctgtctgta aaaacttttg
    16861 tgcacgacta cagtcacgtc ttaattcgcg aagcgatatt gcgcgaaaat ttacgcggcg
    16921 gccaagttta ttttttacat aatgatgtcg caacgctcgc cgcaacggct gaaaaattac
    16981 gaacgattat tcccgaagcc cgtcttgcga tcgcccacgg tcaaatgcgt gaacgtgatt
    17041 tggaacgagt aatgtccgat ttttatcatc agaaatataa tcttttggtt tgtacaacca
    17101 ttattgagtc agggatcgat attcccactg cgaatacgat tattattaat cgcgcggatc
    17161 gattcggctt agctcaactc caccaacttc gcggtcgcgt tgggcgttct catcaccaag
    17221 cctatgctta tttattaata cctgatcaag aagccctgac ggcggatgca gaaaaacgat
    17281 tgagcgctat ttcccaactg gatgatctcg gtgttggttt taacctggcg actcatgatt
    17341 tagaaatccg cggcgcaggc gaattattgg gcgtcgagca aagcggacaa attcatgata
    17401 tcggattttc tttatattta gaattgctgg aagaggcggt aagcgcatta aaagccggac
    17461 gggaacccca atttgaaaag ccattacacg cagcgtctga aattgatctt ggcattacga
    17521 cgcttttacc ggaagattat gtccccgatg ttaatgctcg tcttattctt tataagcgct
    17581 tagctaattg caaaaataaa agagaaatcc aggcgctcaa agaagagctt atcgatcgtt
    17641 ttggcccgct acccccagca gctcaacatt tgctccaatc tgccgaactg cgcttaattg
    17701 caaacgaact cggcatccaa aaaatcaata tcggccccaa atatggctat tttcacttcg
    17761 ataaaaaacc cgccattgat ctcacaaagt taatcaagtt aatccaaacc caaccccaac
    17821 gttaccaact gcaaggcgat gaatccctgc gtttcattct ttctaatccc accccccaat
    17881 ccaaattgga aaccatctac gaattaatta aaaatttgaa gtaactcgta tgaagcgcag
    17941 cgaaatacgg gaacgtcatt atttccccgt atttcgctgc gcttcatacg ggctacttct
    18001 aataatttct taagcttttt ttgatactct attatttatt cagacctgcc atcaaggaag
    18061 accaatcatg agggatattg ctcatgcact gatgaatgtt cttcgaatgg aagataatcc
    18121 cattcattcc ttacgtttaa acgtagtaga aatcccaggt aatcgaatat tgcttaactt
    18181 gcgacaagag gcacccatcc tctcttccca ggcttttcaa tggttagtgg aattatataa
    18241 ccctcctttt aatccttatc ctgttgctca tatcatccgt ataagaatat ttttaactta
    18301 ctctatttta aaaaattgta ccgaaaatac ccggcttaaa gaaagatacg ctacttcctt
    18361 ggaaaacgaa ataataaata aagatcgtat ggggcggggt tacttgctaa cgctgtttga
    18421 actttacggt atcctgacta ttgaccaata cccaaaggat gccgaaggat ggatcatgat
    18481 tgataatgaa ccgataagtt gtcggatacc tgacatcgag ctcttcctga aggatttgca
    18541 gtttttgcga agccaaaacc ggcgtgaggt gaagcctatt gattcttgcc ttccttcaga
    18601 cttgctaaaa atcatagata actattcgga gagggaagga ccttttactt tatttcatca
    18661 aaggcaactt attccacatc agcaatgtaa tttagaagaa aaaaaaccaa acgattccct
    18721 ttcttgacag ccagagctaa aggttgaatt ataaaatttt gtaaaaaggg cgctatttat
    18781 taagtgtggg taaaatcaaa cgatggtgat cacaaactgc gtctgggcct gcttcttgga
    18841 tttcttctaa gctgccatat ccgtaagtaa cgccgatcga tcgcacgtta ttatgtttcg
    18901 cgcctaagat atcgtaacgt cgatctccga tcattaaact ttgtgtgttg cttatctttt
    18961 gggtgtcaag aacataaccg atgagttctt ctttataatc acgcgttcca tccaattctg
    19021 aaccatgaac ggctgtgaaa taatctcgca gattaaaatg atctaaaatc ttacccgcat
    19081 aagcccatgg ttttgaagtg gctaaataaa gttgatagcc atgattgact aacgtttcca
    19141 gcgtttcatg aatgccatcg taaggtttgt tctcaatcgc gcagcggtcc acatagcgtt
    19201 cgcgatagaa atcgatcgct ttttgaagtt gctttttatc tttcgtattg agtaacaatg
    19261 caaaagcatc gattaaaggg ggaccaatcg tccattccaa ttcatccatt gaaggacacg
    19321 cgacgttcat ttgttccaac gcgtattgga ctgaccgagt aatcccctct ttgggatcgg
    19381 tgagtgttcc atccagatca aataaaaggt atttaacgtc tttcatttta caaatcagta
    19441 agtaagcgac cggccagtat accatatcca aatcaattga ggctaccgct atgaacccat
    19501 ctgttgacaa ccgtagcgaa ctgtcgtact attgcagcat tacataaata caacggtgtg
    19561 ttatgccaga aaccctaaca tttgatcaat tcgcaagatt ggccgcccaa gcgccgcgag
    19621 tggtccttca tcaagaaatc ccaggcgata tgcttacgcc aacccaggct ttttatcaat
    19681 tgctggattt gtatccaaca gcgattttgc tggaatttag cccacgcaat gaaaagccct
    19741 acgcttttat cggattcaac ccgttagccc agatcatcgc tcgcggggat gaaattaccg
    19801 tttttttaaa aaacactgtc accaaaatga agggtgaccc cttccatcat ctacgccgtt
    19861 tatgccaaca aatcaattgc attgataacc atccattaac gaaattaaca ggcgcagcaa
    19921 tcggctattt aagttacgat gctatccgtt atgtagaatc tattcctgat cgtcacacag
    19981 cctctgaaaa aattgctgac attgatttta aattttatcg cgatggcatt acctttgatc
    20041 tagaaagcaa taatgccatt gtttctcaca ttgttgaagt taaagacgaa ttaaaacatt
    20101 gctacgaata cggattagaa aaactagccg atattaccaa taatcttttt acgcccgccc
    20161 gcccaaagct ttcgacgaat cgaaaaactc attactcaaa atcaacttcc ctggatttca
    20221 aacccgataa caatgacacc gattttaaaa aaatcgttaa caaggccaag caatacattg
    20281 ccgcgggcga catctttcaa gtcgtgtctt cccgaacttt taaaaaaccg tatcaaggca
    20341 aaccctttga tatctaccgc gctttaaaaa aagtaagccc ttctccctat cacttttatt
    20401 tacaaaatga ttctcttgct atcgccggcg cttcaccgga aaaaatggtt agcgttaaaa
    20461 acggcataat cgacagcgta cctctcgccg gcacgcggcc tcgcggtaac ggcaaaagtg
    20521 atcagacatt agcgcaggaa ttaataaatg atccgaaaga aacggctgag catttaatgc
    20581 tagtggatct cgctcgcaat gatatcggga ttgtttcaca agcgggtagc gtggaagtag
    20641 cagaactgat gcagccggtt aatttttcgc atgtcatgca ccttgcttct cgagttcaag
    20701 gctcattagc aaaaaattat gacgcgattg atgtattaaa agctaccttt cccgctggca
    20761 cgttaagcgg tgcacctaaa attcgagcga tggaaattat cgatgaactc gaacattctc
    20821 gtcgcggttt atacggtggc gccatcgttg ctttagaccg cgacgataat ttagatactt
    20881 gcattattat tcgtacgacg atagtcgaaa atggaatagc ttctattcgc gcgggcgccg
    20941 gtattgttca tgattcggat ccgattgccg aagctaatga aacgcgtcac aaagcgaaaa
    21001 gcgtcatggc cgccatccaa ctggccgaag gaggattata atgattctaa taatcgataa
    21061 ttacgacagt tttacttata atttataaca aaccatcgcc actcattatt cagacgtttg
    21121 cgtttttcgc aacgataaaa ttactattgc gcaaattgca aaacttccca ttcaaggaat
    21181 tattttatcg cccggtcccg gtcgtcctga aaacgctggt atttgtattg aggtcgttaa
    21241 aaaattcgct cctcaatttc ctattttagg agtttgctta gggcatcagg ctatcgccgt
    21301 cgctttcggc gccaaagtga ttaatgctga tgaaattgca catggaaaaa tgacgactat
    21361 ttaccacgac gatgaccctc tttttaaaaa aattccttct ccttttaaag gcggtcgtta
    21421 tcattcacta atcgtcgaca aaaagacatt aacttccgat ttattgctta tcgcagaaaa
    21481 tagagatggg atcgttatgg gaattaaaca caaagtttat ccctgttacg ggattcaatt
    21541 tcatccggaa tcgatattaa cacctgaagg ggatcggtgc ttaattaatt ttcttaaaag
    21601 caccttttta caaaagcaag tttttagaag atcaatgaca accattccac ctgctgaatt
    21661 ttcactttcg ttggaataat tatagaaatg ttaactactt atttaaatca attaatgcaa
    21721 aaaaaagatt taactgaagt tcagtgccgc tctgctatct ttgaaattat taatggagct
    21781 ccgtcggaac aaatcgctgc ttttctagcg cttttgcata acaaatccga aactgcagat
    21841 gaattgtatg gtatcgtttc tgccatgcaa aaccaaatgc tatcgcttcc tttcaatgaa
    21901 acggtactcg atatcgtcgg gacaggcggc gataatgcca acacgataaa tatttccacg
    21961 gcagcctcgc tggtcgttgc cagctatggt attaaagttg ctaaacatgg caaccgcgcg
    22021 gtttcctctc aatgtggcac agccgatttt ttagattcat taaatattcc cattcgcctt
    22081 acgcctcaag aagctaaaaa ttttttaaac gaacgcggat tcgtttttct ttacgcgcct
    22141 gactatcacc ctgccatgaa attaattaaa gagacccgaa aaattttagg catccgcacc
    22201 acctttaatt tacttggacc gctattaaat cctgcttgtc ccacacacct catcgctggt
    22261 gtggctgata aacgcttatt accaatttat tctgatgtgc tcctgcgttc aaacgtaaaa
    22321 cgagctttaa ttgtgcacgg caatggtctg gatgaaatta attgcttagg ccctgttgag
    22381 gttattgaaa tttacaataa taaaaaaaaa tattatcaac tcgatccaaa cgactataat
    22441 ttgaattatt gcagtctatc cgacattcaa ggtggagatt ctcttttaaa taaaaaatta
    22501 atattaacgg cattttctgg gaaagaaagt gcaattagtg ataccattat tttcaatgcg
    22561 ggggtcgctt tttacctgat gaatgttatt tttagcattc aagaagggat caatctcgct
    22621 cgcaggctga ttaaaaatgg aacggtgatc aactatatag aaaaattaag agtcgtttct
    22681 tatgcatgat tatttaaaag caattcttaa aaataaaaag caggaaattg cgcatttgaa
    22741 agcgaatttc tcttccgacg ctttttctct ttcaactaaa aaatccttta aaagaataat
    22801 ttcttctacg cctacaacta tcattgccga aattaaacgg cgttctcctt caaaaggaca
    22861 tttagccgaa attgctgatc cagtcgcctt ggcaaagcaa tatgttcaag gaggtgctgc
    22921 gggagtatca gtccttactg ataaacttgc ttttgatggt tccattcgtg
//
