GCF_000015745.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NC_009328.1 (Geobacillus thermodenitrificans NG80-2)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-i	289,768	316,180	High	geobacillin I	ribosomal:RiPP:Lanthipeptide
Region 1.2	T3PKS	1,474,998	1,516,065
Region 1.3	betalactone	1,521,861	1,546,165	Low	fengycin	NRPS:Type I
Region 1.4	terpene	1,999,009	2,020,862
Region 1.5	lanthipeptide-class-ii,terpene-precursor	2,177,465	2,204,998	High	geobacillin II	ribosomal:RiPP:Lanthipeptide
Region 1.6	terpene-precursor	2,436,984	2,457,877

No secondary metabolite regions were found in these records:: NC_009329.1 (Geobacillus thermodenitrificans NG80-2)

Compact view

NC_009328.1 - Region 1 - lanthipeptide-class-i

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Location: 289,768 - 316,180 nt. (total: 26,413 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: sulfhydrylase

GTNG_RS01585: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: amidase

GTNG_RS01575: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase dehydratase

GTNG_RS01590: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

GTNG_RS01600: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000515.4	1.00	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0000538.3	0.59	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.58	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.58	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.57	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000544.4	0.56	ribosomal	planosporicin	Planomonospora alba
BGC0001789.3	0.56	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000559.4	0.56	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000515.4	1.00	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0000538.3	0.59	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.58	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.58	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.57	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000544.4	0.56	ribosomal	planosporicin	Planomonospora alba
BGC0001789.3	0.56	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000559.4	0.56	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for GTNG_RS01590

GTNG_RS18005

Leader:

MAKFDDFDLDIVVKKQDDVVQPN

Core:

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

Core with dehydrations:

VDhbDhaKDhaLCysDhbPGCysIDhbGVLMCysLDhbQNDhaCysVDhaCysNDhaCysIRCys

antiSMASH-DB 4.0 matches for GTNG_RS18005

100.0%

NC_009328.1and 5 others:

NZ_CP014749.1 Lanthipeptides: A0V43_RS19510_lanthipeptideNZ_CP014749.1 Lanthipeptides: A0V43_RS19510_lanthipeptideNZ_CP017690.1 Lanthipeptides: GTID1_RS08690_lanthipeptideNZ_CP017694.1 Lanthipeptides: GD3902_RS07590_lanthipeptideNZ_PIJH01000004.1 Lanthipeptides: CV632_RS11810_lanthipeptide

Lanthipeptides: GTNG_RS18005_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

97.0%

NZ_CP014140.1:

Lanthipeptides: ACH33_RS18880_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCI+C

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIKC

93.9%

NC_006510.1and 4 others:

NZ_CP018058.1 Lanthipeptides: GT3921_RS18655_lanthipeptideNZ_CP025074.1 Lanthipeptides: CWI35_RS08795_lanthipeptideNZ_CP027303.2 Lanthipeptides: C1N76_RS05790_lanthipeptideNZ_CP038860.1 Lanthipeptides: E5Z46_RS04660_lanthipeptide

Lanthipeptides: GK_RS18085_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

+TSKSLCTPGCITG+LMCLTQNSCVSCNSCIRC

ITSKSLCTPGCITGILMCLTQNSCVSCNSCIRC

with 96 more sequence matches

Only the first 10 are displayed here.

93.9%

NZ_CP023704.1:

Lanthipeptides: CQJ30_RS18315_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

VTSKSLCTPGCITG+LMCLTQNSCVSCNSCI+C

VTSKSLCTPGCITGILMCLTQNSCVSCNSCIKC

69.7%

NZ_AULX01000006.1:

Lanthipeptides: H583_RS0100280_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

+TSKSLCTPGCITGVLMC T+ +S +SCI+C

ITSKSLCTPGCITGVLMCFTKGCEIS-HSCIKC

66.7%

NZ_LT732548.1:

Lanthipeptides: CZ379_RS19505_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

+TSKSLCTPGCITGVLMC T+ +S +SC++C

ITSKSLCTPGCITGVLMCFTKGCEIS-HSCVKC

60.6%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNSC

+TSKSLCTPGC TG L C TQN C N C

ITSKSLCTPGCPTGALGCFTQN-CDPTNGC

51.4%

NZ_CP113114.1and 1 other:

NZ_FZDV01000015.1 Lanthipeptides: CFW84_RS08635_lanthipeptide

Lanthipeptides: OTU45_RS07045_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNS

+TS SLCTPGC+TGVLMC + +SCN

ITSVSLCTPGCVTGVLMC--PGNTISCNG

48.5%

NZ_CP021903.1and 20 others:

NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptideNZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptideNZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptideNZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptideNZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptideNZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptideNZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptideNZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptideNZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptideNZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptideNZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptideNZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptideNZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptideNZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptideNZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptideNZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptideNZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide

Lanthipeptides: CD007_RS17065_lanthipeptide

SKSLCTPGCITGVLM-CLTQNSCVSCN

S+SLCTPGC+TGVL C Q ++CN

SESLCTPGCVTGVLQTCFLQT--ITCN

48.5%

NZ_CP116604.1and 2 others:

NZ_JAFFHI010000008.1 Lanthipeptides: JN541_RS08535_lanthipeptideNZ_JAFFHJ010000004.1 Lanthipeptides: JN542_RS06245_lanthipeptide

Lanthipeptides: PHA78_RS04905_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCN

+TS SLCT GCITG +M + VSCN

ITSISLCTAGCITGRIMGCHKTPTVSCN

48.5%

NZ_GG667191.1and 1 other:

NZ_GG667191.1 Lanthipeptides: HMPREF0298_RS11685_lanthipeptide

Lanthipeptides: HMPREF0298_RS11685_lanthipeptide

VTSKSLCTPGCITGVLMCLT

+TSKSLCTPGCITG +MC T

ITSKSLCTPGCITGWMMCNT

45.7%

NZ_JALDTZ010000003.1:

Lanthipeptides: M1F37_RS03135_lanthipeptide

VTSKSLCTPGCITGVLMCLTQNSCVSCNS

+TS+S CTPGC+TG+LMC + +SCN

ITSRSFCTPGCVTGILMC--PGNTISCNG

45.5%

NC_015600.1and 14 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

VTSKSLCTPGCITGVLM

VTSKSLCTPGC TG+LM

VTSKSLCTPGCKTGILM

MIBiG 4.0 matches for GTNG_RS18005

38.2%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

VTSKSLCTPGCITGVLM

+TS SLCTPGC TG LM

ITSISLCTPGCKTGALM

15.2%

BGC0002144.3 (RCCGEPOP_RS37510):

LAP: phazolicin

SCVSCNSCIRC

+C C+S RC

TCARCDSSSRC

12.1%

BGC0002111.3 (multiple genes):

Lanthipeptide: andalusicin A or andalusicin B

GVLMCLTQNSC

GV N+C

GVWASTISNNC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.04 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.18 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.09 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.18 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.67 out of 28.19

Confidence: medium

Additional weak hits (3):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.27 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.48 out of 30.25

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

GTNG_RS18005 - Class I

Cleavage pHMM score: 17.80

RODEO score: 29

Monoisotopic mass: 3261.5 Da

Molecular weight: 3263.9 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3281.9 Da N = 1; 3300.0 Da N = 2

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 152 - 241; Score: 61.0

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NC_009328.1 - Region 2 - T3PKS

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Location: 1,474,998 - 1,516,065 nt. (total: 41,068 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

GTNG_RS07410: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: esterase

GTNG_RS07460: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

Ligases: synthase

GTNG_RS07405: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002127.3	0.51	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001238.3	0.51	other (other)	biotin	Aspergillus nidulans
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001239.3	0.49	other (other)	biotin	Aspergillus nidulans
BGC0000902.4	0.49	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.44	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002127.3	0.51	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001238.3	0.51	other (other)	biotin	Aspergillus nidulans
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001239.3	0.49	other (other)	biotin	Aspergillus nidulans
BGC0000902.4	0.49	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.44	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.48 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.15 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.77 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.00 out of 27.78

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 26.86 out of 30.98

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.18 out of 32.93

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.71 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (15):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.60 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.60 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.05 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.81 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.83 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.88 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.61 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.19 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.53 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.82 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.36 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.13 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
NuR	Nickel-responsive regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NC_009328.1 - Region 3 - betalactone

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Location: 1,521,861 - 1,546,165 nt. (total: 24,305 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

GTNG_RS07605: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase

GTNG_RS07615: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

GTNG_RS07635: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: hydratase

GTNG_RS07630: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

GTNG_RS07580: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

GTNG_RS07610: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

GTNG_RS07625: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000131.5	0.47	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000207.5	0.46	PKS	chartreusin	Streptomyces chartreusis
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001103.5	0.45	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001095.5	0.43	NRPS	fengycin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000131.5	0.47	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000207.5	0.46	PKS	chartreusin	Streptomyces chartreusis
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001103.5	0.45	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001095.5	0.43	NRPS	fengycin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.58 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.28 out of 28.19

Confidence: medium

Additional weak hits (6):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.47 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.62 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.18 out of 29.38

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.22 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.69 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NC_009328.1 - Region 4 - terpene

Download region GenBank file

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Location: 1,999,009 - 2,020,862 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

GTNG_RS09775: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

GTNG_RS09805: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: hydratase

GTNG_RS09855: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase

GTNG_RS09850: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.55	NRPS	AM-toxin	Alternaria alternata
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002474.2	0.43	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0002493.3	0.42	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.42	PKS	oviedomycin	Streptomyces antibioticus
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000888.5	0.41	other (other)	bacilysin	Bacillus sp. CS93

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.55	NRPS	AM-toxin	Alternaria alternata
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002474.2	0.43	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0002493.3	0.42	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.42	PKS	oviedomycin	Streptomyces antibioticus
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000888.5	0.41	other (other)	bacilysin	Bacillus sp. CS93

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

GTNG_RS09815: T2TS

Domain 1 (8 - 611): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.11 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.71 out of 23.79

Confidence: medium

Additional weak hits (5):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.00 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.31 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.77 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.57 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.73 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism

NC_009328.1 - Region 5 - lanthipeptide-class-ii,terpene-precursor

Download region GenBank file

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Location: 2,177,465 - 2,204,998 nt. (total: 27,534 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

GTNG_RS10715: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthetase

GTNG_RS10735: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	1.98	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.46	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.42	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.38	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.38	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000527.5	0.37	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.5	0.33	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0002005.2	0.31	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000502.5	0.30	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000525.5	0.30	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	1.00	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.51	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000527.5	0.51	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.5	0.47	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0002005.2	0.46	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for GTNG_RS10715

GTNG_RS18990

Leader:

MEKQEQTFVSKISEEELKKLAGG

Core:

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

Core with dehydrations:

YDhbEVDhaPQDhaDhbIVCysVDhaLRICysNWDhaLRFCysPDhaFKVRCysPM

antiSMASH-DB 4.0 matches for GTNG_RS18990

100.0%

NC_009328.1:

Lanthipeptides: GTNG_RS18990_lanthipeptide

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

97.1%

NZ_PIJH01000018.1:

Lanthipeptides: CV632_RS18055_lanthipeptide

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

YTEVSPQSTIVCVSLRICNWSLRFCPSFKV+CPM

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

64.7%

NZ_FOHE01000009.1:

Lanthipeptides: BMX40_RS20255_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

EV+PQST+VCVSLR+C WS+++CPSFK +C M

EVTPQSTVVCVSLRLCKWSIKYCPSFKRKCWM

with 20 more sequence matches

Only the first 10 are displayed here.

64.7%

NZ_JALANL010000003.1and 3 others:

NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptideNZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptideNZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide

Lanthipeptides: MOC63_RS03255_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

E++PQST+VCVSLRIC WS+++CPSFK +C M

EITPQSTVVCVSLRICKWSIKYCPSFKRKCWM

61.8%

NZ_CP023481.1and 2 others:

NZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptideNZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide

Lanthipeptides: COP00_RS24795_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

E++PQST+VCVSLR+C WS+++CPSFK +C M

EITPQSTVVCVSLRVCKWSIKYCPSFKRKCWM

61.8%

NZ_JALAJI010000006.1and 3 others:

NZ_JALAOO010000008.1 Lanthipeptides: MOC69_RS16910_lanthipeptideNZ_JALAXE010000008.1 Lanthipeptides: MOF11_RS14910_lanthipeptideNZ_JALAXI010000013.1 Lanthipeptides: MOE73_RS14185_lanthipeptide

Lanthipeptides: MOB90_RS08905_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

E++PQST+VCVSLR+C WS+++CPSFK +C M

EITPQSTVVCVSLRLCKWSIKYCPSFKKKCLM

41.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

EVSPQSTIVC-VSLRIC-NWSLRFCPS

EV PQS VC V+L +C SL FCP+

EVRPQSGPVCAVTLAVCVPVSLAFCPT

40.0%

NZ_CP039297.1and 4 others:

NZ_CP040378.1 Lanthipeptides: D1120_RS00435_lanthipeptideNZ_CP040672.1 Lanthipeptides: FGE23_RS05605_lanthipeptideNZ_CP059318.1 Lanthipeptides: HZT45_RS00565_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS00585_lanthipeptide

Lanthipeptides: E4T61_RS00570_lanthipeptide

TEVSPQSTIVCVSLRICNWSLRFCPSFKVRC

T VSP T+V +R+ SL+ CP+FK++C

TPVSPAPTVV---IRV---SLKVCPTFKIKC

32.4%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

STIVCVSLRICNWSLRFCPSFKVRCP

+TI+ VSL +C + C SF CP

TTIIPVSLAVCPTTT--CRSFSSPCP

29.4%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

EVSPQS-TIVCVSLRIC

E +P + TIV VSL IC

ETTPATPTIVAVSLGIC

26.5%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVRC

+V+P+ST VC + S++ + K +C

DVTPESTTVCAAFASFAGSIQLVKTLKSKC

23.5%

NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

TEVSPQSTIVCVSLRI-CNWSLRFC

++V P++T +CV + I S++ C

SDVQPETTPLCVGVIIGITASIKIC

23.5%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

TEVSPQSTIVCVSLRICN--WSLRFC

++V+P++T CV+ +S++FC

SDVAPETTPACVAAFATGLLFSIKFC

MIBiG 4.0 matches for GTNG_RS18990

14.7%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

VSLRICNWS

VSL +C +S

VSLLVCEYS

14.7%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

CNWSLRFCPS

CN FC S

CNCVCGFCCS

allorf_2183040_2183105

Leader:

MLHSRAGS

Core:

MRLALELALSCCS

Core with dehydrations:

MRLALELALDhaCysCysDha

antiSMASH-DB 4.0 matches for allorf_2183040_2183105

100.0%

NC_009328.1:

Lanthipeptides: allorf_2183040_2183105_lanthipeptide

MRLALELALSCCS

allorf_2195153_2195332

Leader:

MVWSPLPYRKIRIFCTLYFLYFPTAFYVNISSTTCGEEPKNSLFA

Core:

IFCYFHQSQNMLVG

Core with dehydrations:

IFCysYFHQDhaQNMLVG

antiSMASH-DB 4.0 matches for allorf_2195153_2195332

100.0%

NC_009328.1:

Lanthipeptides: allorf_2195153_2195332_lanthipeptide

IFCYFHQSQNMLVG

22.6%

NZ_CP006269.1:

Lanthipeptides: allorf_1795731_1795883_lanthipeptide

FCY-----FHQSQNMLVG

+CY Q QN+L+G

WCYSVAMRVAQQQNLLIG

allorf_2195161_2195337

Leader:

MVWFGHLYHTGKFAFFVPSIFFIFLLRSMSIYQVQLVVKSQKTHSSPFS

Core:

ATSTNPKIC

Core with dehydrations:

ADhbDhaDhbNPKICys

antiSMASH-DB 4.0 matches for allorf_2195161_2195337

100.0%

NC_009328.1and 1 other:

NZ_PIJH01000018.1 Lanthipeptides: allorf_25318_25410_lanthipeptide

Lanthipeptides: allorf_2195161_2195337_lanthipeptide

ATSTNPKIC

9.7%

NZ_CP017599.1:

Lanthipeptides: BJP34_RS00845_lanthipeptide

TSTNPKIC

TSTN +IC

TSTNDEIC

allorf_2196525_2196659

Leader:

MIDASTSFG

Core:

DEPEYNIIANMLHSTISDKTRRGVSSSFCALFYMI

Core with dehydrations:

DEPEYNIIANMLHDhaDhbIDhaDKDhbRRGVDhaDhaDhaFCysALFYMI

antiSMASH-DB 4.0 matches for allorf_2196525_2196659

100.0%

NC_009328.1:

Lanthipeptides: allorf_2196525_2196659_lanthipeptide

DEPEYNIIANMLHSTISDKTRRGVSSSFCALFYMI

14.3%

NZ_CP028286.1:

Lanthipeptides: allorf_098636_098806_lanthipeptide

NIIANMLHSTISDKTRRGV

N++ + +STI+ + +G+

NVLFTVCYSTIASRKNKGI

MIBiG 4.0 matches for allorf_2196525_2196659

13.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

GVSSSFC

GVS++FC

GVSAAFC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

GTNG_RS10735: PT_FPPS_like

Domain 1 (52 - 301): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.50 out of 24.78

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.52 out of 24.78

Confidence: medium

Additional weak hits (5):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.52 out of 29.51

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.06 out of 39.62

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.67 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88

Confidence: weak

Lanthipeptides

Terpene

TFBS Finder

Core peptide predictions

GTNG_RS18990 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3822.9 Da

Molecular weight: 3825.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3843.6 Da N = 1; 3861.6 Da N = 2; 3879.6 Da N = 3

allorf_2183040_2183105 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 1372.7 Da

Molecular weight: 1373.7 Da

Number of bridges: 2

allorf_2195153_2195332 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 1667.8 Da

Molecular weight: 1668.9 Da

Number of bridges: 1

allorf_2195161_2195337 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 879.5 Da

Molecular weight: 880.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 898.0 Da N = 1; 916.0 Da N = 2

allorf_2196525_2196659 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 3881.9 Da

Molecular weight: 3884.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3902.4 Da N = 1; 3920.4 Da N = 2; 3938.4 Da N = 3; 3956.5 Da N = 4; 3974.5 Da N = 5; 3992.5 Da N = 6

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
LexA variant 2	Repressor of DNA damage response
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NC_009328.1 - Region 6 - terpene-precursor

Download region GenBank file

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Location: 2,436,984 - 2,457,877 nt. (total: 20,894 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

GTNG_RS12050: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

GTNG_RS12015: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

GTNG_RS12020: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

GTNG_RS12020: PT_FPPS_like

Domain 1 (34 - 297): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06

Confidence: medium

Additional weak hits (9):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.82 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.82 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.35 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.73 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.91 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.31 out of 30.97

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.98 out of 24.78

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis