LOCUS       NC_007777              25787 bp    DNA     circular CON 05-SEP-2024
DEFINITION  Frankia casuarinae, complete sequence.
ACCESSION   NC_007777
VERSION     NC_007777.1
KEYWORDS    RefSeq.
SOURCE      Frankia casuarinae
  ORGANISM  Frankia casuarinae
            Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
            Frankia.
REFERENCE   1  (bases 1 to 5433628)
  AUTHORS   Normand,P., Lapierre,P., Tisa,L.S., Gogarten,J.P., Alloisio,N.,
            Bagnarol,E., Bassi,C.A., Berry,A.M., Bickhart,D.M., Choisne,N.,
            Couloux,A., Cournoyer,B., Cruveiller,S., Daubin,V., Demange,N.,
            Francino,M.P., Goltsman,E., Huang,Y., Kopp,O.R., Labarre,L.,
            Lapidus,A., Lavire,C., Marechal,J., Martinez,M., Mastronunzio,J.E.,
            Mullin,B.C., Niemann,J., Pujic,P., Rawnsley,T., Rouy,Z.,
            Schenowitz,C., Sellstedt,A., Tavares,F., Tomkins,J.P., Vallenet,D.,
            Valverde,C., Wall,L.G., Wang,Y., Medigue,C. and Benson,D.R.
  TITLE     Genome characteristics of facultatively symbiotic Frankia sp.
            strains reflect host range and host plant biogeography
  JOURNAL   Genome Res 17 (1), 7-15 (2007)
   PUBMED   17151343
REFERENCE   2  (bases 1 to 5433628)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,J.C.,
            Glavina,T., Hammon,N., Israni,S., Pitluck,S., Goltsman,E.,
            Martinez,M., Schmutz,J., Larimer,F., Land,M., Kyrpides,N.,
            Lykidis,A., Francino,P., Benson,D.R., Huang,Y., Mastronunzio,J.,
            Bickhart,D., Niemann,J., Rawnsley,T., Tisa,L.S. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2006) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000013345.1-RS_2024_09_05
            Annotation Date                   :: 09/05/2024 02:41:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,755
            CDSs (total)                      :: 4,702
            Genes (coding)                    :: 4,516
            CDSs (with protein)               :: 4,516
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 53 of 186
            Pseudo Genes (incomplete)         :: 162 of 186
            Pseudo Genes (internal stop)      :: 10 of 186
            Pseudo Genes (multiple problems)  :: 37 of 186
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:46:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5037525
            Orig. end                         :: 5063312
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000249.1.
            URL -- http://www.jgi.doe.gov
            Source DNA and bacteria available from Louis Tisa
            (lst@patia.unh.edu)
            Contact: Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-PGF
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25787
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene"
                     /product="azole-containing-RiPP"
                     /region_number="26"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..25787
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22256
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22256
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12256](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12256
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            111..1394
                     /locus_tag="FRANCCI3_RS21340"
                     /old_locus_tag="Francci3_4220"
     CDS             111..1394
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011435125.1"
                     /locus_tag="FRANCCI3_RS21340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4220"
                     /product="ISAs1 family transposase"
                     /protein_id="WP_049760812.1"
                     /transl_table=11
                     /translation="MPVTPTDLGQAGSGQLVRMRRSLRVLGAHGGEVQGLADVLAGVPD
                     PRDPRGIRHRLPVILGLSAAAVAAGEKSVEEIAAWAAHAPTQVLTALGARVHPVTGQPQ
                     APSVDTMIRVLSAVDSSALARAVGMFAAARARQARGGGRRVVAVDGKTLRGAAGPEGRA
                     PHLLAVAEHGTGVVLAEHEVGAKTNEVTAFAPLLRELHSHDPLDGVVVTADALHTTRAH
                     ADLIVTELGAHFVFTVKANTPALSVDCHQATDWTKIPIGHSAEGRAHGRFERRTIQLAQ
                     ASEAIRARYPHARTVARIRRHVRRTVTTGTGRARVTRTIPSTVTVHVLTSLTLDAVTPA
                     DLAGYARGHWTIENKVHWVRDVTFREDASRVRTGPLPRIMTTLRNLIIGLIRLAGHNRI
                     APTIRRIRHDNALLLAILTLDNPADLHQ"
     gene            <1777..2598
                     /locus_tag="FRANCCI3_RS25120"
                     /pseudo=""
     CDS             <1777..2598
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029008.1"
                     /locus_tag="FRANCCI3_RS25120"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="NNLAEAVRQKVAAHSTCRAKAAPPPIREGARAITTRERWAQVHNL
                     LDKGVGLLECSRRLGLTLNTVTRYARISEPERLIRAPQYRPTLVDP"
     cand_cluster    2257..25787
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    2257..25787
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12256:15787](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(12257..15787)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="2"
     gene            complement(2611..2949)
                     /locus_tag="FRANCCI3_RS28820"
                     /old_locus_tag="Francci3_4224"
     CDS             complement(2611..2949)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025180.5"
                     /locus_tag="FRANCCI3_RS28820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4224"
                     /product="transposase family protein"
                     /protein_id="WP_083503475.1"
                     /transl_table=11
                     /translation="MPVQSRKPAEVSHPAGEAQEALAVLATAGGPVAECFEQIPDPRDP
                     RGVRHRLPVVLSLCAAVLCGESGLAGVAAWVAAEGPGDPTGEGCRWPRPGIAVDGAVKF
                     SALSQIRW"
     gene            complement(3124..4113)
                     /locus_tag="FRANCCI3_RS25125"
                     /pseudo=""
     CDS             complement(3124..4113)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612357.1"
                     /locus_tag="FRANCCI3_RS25125"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRGDLTDGEWELIEPYLPLGASGLIPDLRSYVNAVMWRFRTGSP
                     WRDVPERYGSWSTIYDRFRLWAQDGVFQTLMDAMITEAAARDDVDLSLASVDSTVARAH
                     HHAAGMVVDPDLLVDLEKALTEEKGLQKPGKTTV"
     gene            complement(4343..5596)
                     /locus_tag="FRANCCI3_RS21385"
                     /old_locus_tag="Francci3_4227"
     CDS             complement(4343..5596)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020460374.1"
                     /locus_tag="FRANCCI3_RS21385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4227"
                     /product="IS701 family transposase"
                     /protein_id="WP_041258262.1"
                     /transl_table=11
                     /translation="MELGEMGRVRPVIERFAGEMFADLPRRDQRGKGELYVQRLLTDGK
                     RKSMVPMAARLGVDPQQLQQFVTSSTWDYRQVRRRLTGWAAGFCDPVALVVDDTGFPEG
                     RAASPGVARMYSGTLGKVGNCQIGVSVHAVTDWASAAVAWRLFLPTCWDDTTLTDPTEV
                     AAARARERAAIPDKARHREKWRLVLDMIDELAGWGMPVRPVVADAGYGDAAAFRQGLTD
                     RNIPYVLAVKPTATAYPADAVPVTAPYPGNSRRPTPAYPDPPRDLKSLVMAAGRRTGRS
                     VTWRHGTHRTPANPTAGMRSRFLALRVRPAGRNITRNPDRSLPVCWLLAEWPVGQPEPT
                     DYWLSTLPTGIPLRDLVRLAKIRWRIEHDYRELKDGLGLDHFEGRTFAGWHRHVTLVRV
                     AQALCTQLRRTPKVPAPA"
     misc_feature    complement(5617..5631)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.18"
                     /tool="antismash"
     gene            complement(5960..6550)
                     /locus_tag="FRANCCI3_RS21390"
                     /old_locus_tag="Francci3_4228"
     CDS             complement(5960..6550)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438583.1"
                     /locus_tag="FRANCCI3_RS21390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4228"
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_011438583.1"
                     /transl_table=11
                     /translation="MPINDAGFDGGRAAQFSHDDVVGVLLEQHARIRELFADVKSAAGE
                     HKRRAFDELRALLAAHETAEEMVVRPVTKKIDSRVAEARNHEEDEATRVLLALEKMDVG
                     SAEFDAKLADFERAVVDHAEHEENEEFPRVHAARDARQLESMGRRLRTAEKFAPTHPHP
                     SAAGSTAKQWTVGPIASVIDHVRDAVTRRGAVD"
     gene            8268..9671
                     /locus_tag="FRANCCI3_RS21395"
                     /old_locus_tag="Francci3_4230"
     CDS             8268..9671
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438585.1"
                     /locus_tag="FRANCCI3_RS21395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4230"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_011438585.1"
                     /transl_table=11
                     /translation="MTEPVQAGTDAGGEEPRLSLSTAAARNLATTTKSVPQMQEITSRW
                     LLRILPWVQASGGVYRVNRRLTYVLGDGLLTFTTTGSEVRVVPRELGELPALRGFDGEV
                     LDALADRFAQREFAAGDVLVESGQAADQVFLIAHGKVGRFGLGEYGDERELGVLADGEY
                     FGDEALVEEDLTWEFTARALTGTTALVLSRQQFSELADSSDELRRHLDEYRTRLQPPSN
                     RLGEAEIAIAAGHTGEPDLPGTFVDYELAPREYELSVAQTVLRIHSRVADLYNEPHNQL
                     EHQIRLTVEALRERQEHELVNNPDFGLLHNADLRQRIHTRSGPPTPDDLDDLLSRRRST
                     HFLLAHPRTIAAFGRECTARGIYPATVLLHDQHVPAWRGVPLLPLNKIPISGTGTTSIL
                     ALRTGEENQGVIGLHHAGLPDEYEPGLSVRFAGISDKAIISYLVTTYYSAAVLVPDALG
                     ILENVEIGR"
     gene            10001..12256
                     /locus_tag="FRANCCI3_RS21400"
                     /old_locus_tag="Francci3_4231"
     CDS             10001..12256
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438586.1"
                     /locus_tag="FRANCCI3_RS21400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4231"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_011438586.1"
                     /sec_met_domain="T1TS (E-value: 3.9e-78, bitscore: 261.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPFTLPEFYVPYPARLNPNLEQARVHSRAWADEMEMIDSPQHGT
                     AIWTEADFDAHDYALLCAYTHPDSVSRKLDLVTDWYVWVFYFDDHFLELYKRSHDMAGA
                     RAYLDRLPAFMPVDGEITETPTNPVERGLADLWTRTVPERSADWRRRFAVSTKNLLDES
                     LWELANINAGRLANPIEYVEMRRKVGGAPWSANLVEHAADAEVPAQVAATRPLQVLRDT
                     FADAVHLRNDLFSYQREVEEEGELSNGVLVIERFLGCGTQEAADTVNDLLTSRLHQFEH
                     TAVTELPAVLEEHGVDPGSRLEVLAYVKGLQDWQSGGHEWHLRSSRYMNRAVAPESGEL
                     SGLLGLTGLGTSAARIVPSLVTTTPRRIRSFTHIPHQIVGPLRHPDFCMPFSTGQSPHL
                     DASRRENIIWARAVGMLDPIPGIWDEHKLRAFDFALCSAGIHPDATLPELNLTTDWLTW
                     GTYADDYYPVIFGRTRDILGAKVCNARLSEFMPLDSPVTAVPANALERGLADLWTRTTE
                     TMAPGARETFRGTVEVMIDSWLWELANQAQNRIPDPIDYIEMRRATFGSDLTMSLARLA
                     RLAQEQTVPPEIYRTRPIQALENAAADYACLLNDVFSYQKEIQFEGEIHNCVLVVENFL
                     DCDRERALAVVNDLMTSRIRQFEHIVAHELPALFDSFALDASARQALLGYARELQNWLA
                     GILRWHEGTHRYEESELRYHPAAGVRPFGGPTGLGTSSAHVRPRPAAAAGAAGDSEM"
     gene            complement(12257..13009)
                     /locus_tag="FRANCCI3_RS21405"
                     /old_locus_tag="Francci3_4232"
     CDS             complement(12257..13009)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438587.1"
                     /locus_tag="FRANCCI3_RS21405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4232"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_011438587.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-33, bitscore:
                     114.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEDVTALERIRRVQQVLNGPPTRQVMLDGLRAATCRIPLPAPRA
                     DLPVEFGQVLAARRSWYRFDAEAPTAENVSSLLRWAVGPQRDVRLPDGSQHRMWMAPSA
                     GGLHSLSIYLVIARGAQLPGGVFRYDAEDHCLQTLRSGEPTAALRSVLVQPEFAERAPM
                     AVVVVARLDTTLVKYPARHYRTLHLDAGIAVQNLYLVAAALGLAGCAVTAFDDQALAEL
                     LRLPDTMFPTVVFPVGRQPVRPPTRHAS"
     misc_feature    12994..13008
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            complement(13040..14377)
                     /locus_tag="FRANCCI3_RS21410"
                     /old_locus_tag="Francci3_4233"
     CDS             complement(13040..14377)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438588.1"
                     /locus_tag="FRANCCI3_RS21410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4233"
                     /product="YcaO-like family protein"
                     /protein_id="WP_011438588.1"
                     /sec_met_domain="YcaO (E-value: 4.8e-70, bitscore: 235.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 4.2e-106, bitscore:
                     353.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLAAILAPRTGIIRRIERNAIPATLPPEFTMYTAVLSDTTRFSA
                     WASDFAGAGYALLDDDAALGPAVGEAVERYCGNLVPAGLRRATHKELTADRATVLDPRS
                     VVLYSPAQYAGPYFPFTEYREDLELEWTSGTDLLAGTPVWVPAQLVWVSYAHQAQARGF
                     PYLSPVLSAGLAAGMDQRSAQWSAICQMIERDTLTMAWHGRRPLRAITPPPWIAQLAMG
                     AYGSMTTRFVEFPNEFGLVVVGALVHDTATGYLTMGAACRTTTTPALRKALAEAFQLQM
                     FVADLDDSDGPYMRAARNPHSPLKPWRADRRYLDDCRDDLADVVEYCTHLQLFLDSRLQ
                     DRLEAELAEALTGTIGWETLDRDARHAGVDDPTVLARTLADAGHPVTSVDVTTEDVRPT
                     GMRVVHTLAPGLYSNTSVGLPFLGGARLARQLAAAGTTRRDLPLPH"
     gene            complement(14387..15787)
                     /locus_tag="FRANCCI3_RS21415"
                     /old_locus_tag="Francci3_4234"
     CDS             complement(14387..15787)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438589.1"
                     /locus_tag="FRANCCI3_RS21415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4234"
                     /product="YcaO-like family protein"
                     /protein_id="WP_011438589.1"
                     /sec_met_domain="YcaO (E-value: 8.1e-84, bitscore: 280.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.3e-115, bitscore:
                     384.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTTPAPAERRLVDRRLGVLTQIVPYQPSPAMPRCWVGWSARAA
                     DTRAFATWSAERFGFGAALGDHDRARRAAVGEAVERYCGNAVPDALEIACYDDLARAGR
                     PALDPATLALYSDRQYRARGFPFRPFTRQTPVAWVPGRDLYAGGPVLVPASMAYLNYFR
                     GAHADEVATHAMLYAGIATGENREHAERFALEELFERDANTIWWASGAAGWAVADAAEL
                     LDRYDIAHGEGTGRTIRLFQVPSQFPVPVLAAFLEEPGRGLIAYGTACRADPREAATKA
                     LVEAFAMLELTAELADGDSAHWRAVARGEIPPHTYLPYRADRRYADDIRPDFRDLVDLP
                     AVAQLYLDPRMQGRPLDRLRDDTRTTRLADIPRADGDANGGTAHRRYLDMLATQGLSAV
                     SVDVTTPDVRAAGLTVVRVIVPGLYGNPPAAFPFLGGERLYDVPAQLGLAAGKITEDAL
                     YPYPIPHV"
     gene            complement(15784..17397)
                     /locus_tag="FRANCCI3_RS21420"
                     /old_locus_tag="Francci3_4235"
     CDS             complement(15784..17397)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438590.1"
                     /locus_tag="FRANCCI3_RS21420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4235"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_011438590.1"
                     /sec_met_domain="PF00561 (E-value: 4.1e-05, bitscore: 21.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAIDANQAVPAADGVLLATDVYRPDRLPAPAVVTRTPYGRGSLL
                     ANGVGWARNGLAYVAQDVRGRYGSGGTWTPYQGERADGRALVEWVHRQPWCDGNVILAG
                     ASYGSFTAWAAAVTVPELVRAVISEVPAAGLRPANVDPSGILRLAEYAGWWAEHAESRT
                     SRNGLSAQMLGCEPDLLRHLPVADLGRHLWARVPRWWSAIAPALSAPALSAPAPLTTGD
                     SPAPHDRTGDDLGEGISTQELARCSLPSLHIGGWYDLFLPQTLWQWETAGRDRAPNRPA
                     RGLVIGPWGHELSTPASSSAGGREHGPASQLPLGRLQVAWIFDVLAGRDASITKVFLVE
                     GGRWLDRWPASTATLGLQASADGSLLPNPPERPAEHRFTYDPLDPFPSLPRDCDRAPLD
                     ARADAVAFRTPPLTTPTAIVGAPTVTMAADTTGPGTDWIVRLVERLGDGRALEVTSGAA
                     AVGPGAATVSIPLGATALLLHPGSRLELQVTSSDFPRLARTPNTGQDRYTTSATRIATQ
                     TIHTGPTRGCRVDLPVLEHP"
     gene            complement(17408..18217)
                     /locus_tag="FRANCCI3_RS21425"
                     /old_locus_tag="Francci3_4236"
     CDS             complement(17408..18217)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438591.1"
                     /locus_tag="FRANCCI3_RS21425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4236"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_011438591.1"
                     /transl_table=11
                     /translation="MFSPGHHLYRAADGSWRYSAPGDVFVRIGGEDRLLALVRNVAAGA
                     TQLPLPDADRPAVERMTAALTDRGVFVGPGRAGTVPAGWKVHLDGDSPVVGKLTELLGD
                     IIDDVECTVGPADEAAVAGSDAVVSCARWLPDSHWCRLDQWCAAHHTPWHGCYAEGDTF
                     VVGPLSMPGRTACYRDTRGRRLAAAALPDELIAHWAYLDSDAVKPPAPFTPAATAVLAG
                     LLAADLRALAAGSTVPSEGHQLVVDPTTASISRHPVLPLPNLAVNPV"
     gene            complement(18467..18580)
                     /locus_tag="FRANCCI3_RS28630"
     CDS             complement(18467..18580)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040715.1"
                     /locus_tag="FRANCCI3_RS28630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine-related RiPP repeat protein"
                     /protein_id="WP_023840694.1"
                     /transl_table=11
                     /translation="MAEISFEELAEAPVLAAPQDPTTHALVQSPFAWDDEE"
     misc_feature    18604..18618
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(18606..18617)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.61"
                     /tool="antismash"
     misc_feature    18607..18621
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.65"
                     /tool="antismash"
     misc_feature    complement(18608..18621)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.14"
                     /tool="antismash"
     gene            complement(18692..20020)
                     /locus_tag="FRANCCI3_RS21430"
                     /old_locus_tag="Francci3_4238"
     CDS             complement(18692..20020)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438593.1"
                     /locus_tag="FRANCCI3_RS21430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4238"
                     /product="MFS transporter"
                     /protein_id="WP_083282201.1"
                     /transl_table=11
                     /translation="MSTVPAFRLFLASRAVSWAGSAMTLVALPVLLFQRTGSGTLAGVL
                     VGLEAVPYLVLGLPAGALVDRWDHRRTMVVTSCLSGLTMASIPVANWAGVLTTPHLLIS
                     AVLVASVFVFFDAASFGAVPAIVGRDAVAAATGAMVSVSTVVNLVGPAVGGVAAATVGA
                     ASVLALDALSYLVGAILLSRARWAVPAAADRSRADRSGPAGSRVSRTRRDIAEGLGYIR
                     GHRLIRTLTLLGAGSSLSGGAVTGLVVVVAVRQFGLPDDDPRIGLLYVAAALGTLIVSQ
                     LLSRVHRHVPTGTITLGALGASTLALIGWSLNTAWLPGMGILLLWQASTSLVILNGIVV
                     RQAVTPLRLQARVNTTARMIAWGGTPLGAVLAGILADAWGTRAALLTASAGVGLALVAG
                     LMAGLGHTGRLQDLIRADEAPANPPQAGPGGPDAAVRAVTAAE"
     gene            complement(20077..21078)
                     /locus_tag="FRANCCI3_RS21435"
                     /old_locus_tag="Francci3_4239"
     CDS             complement(20077..21078)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438594.1"
                     /locus_tag="FRANCCI3_RS21435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4239"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_011438594.1"
                     /transl_table=11
                     /translation="MKKLGAGVAVAALLVVTAGLTGCGSGSTTGAGSASAADARSAPAG
                     TRYPVEVANCGRTLHFDEAPARVVSGWTTSTELLIELGLTDRIVGQYNTSSGTPAAKYA
                     SVEAKLPALGTGAPTREALLAARPDLIWADGSYLFDGRQLPTIAELAAQGTQVMILSGF
                     CTDDATKATVRDVDTDLTALGMIFGIPGRARQVQADINERLRQVATKIQGRDPVPVAVV
                     ATYQGTVYTYDGVYTDIARLAGARNIYAGTLPKGKYFSELSVEDLISKNPGTLVYLLSG
                     SETEAEARKFLTSRLPTVAAVRNNRVFFLPQSDSANLAGVEGVTKLAAALHA"
     gene            complement(21111..21968)
                     /locus_tag="FRANCCI3_RS21440"
                     /old_locus_tag="Francci3_4240"
     CDS             complement(21111..21968)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438595.1"
                     /locus_tag="FRANCCI3_RS21440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4240"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_011438595.1"
                     /transl_table=11
                     /translation="MTGLRLEGLGVVADGVQIVRDLTVGCPPGAFVGLVGPNGSGKSTV
                     LKTVYRVVRPTSGAVLLDGTDLVRDLTPRQSARRVAALAQESPDGFDFTVLEVVATGRT
                     PHQSAWSPTSTGDHEIISAALDTVGMAAHAGRAFASLSGGEKQRVLLARALVQAPSVLI
                     LDEPTNHLDISTQLSLLELVRSLGITVLAALHDLNLATAFCDRLYVLHDGAVICSGKPE
                     DVLTADLIGRVFGVRADRSVHPVTGRLQLAFSSLPFPSLPSSSLPGTDEPAPVVAGAEI
                     PIKQ"
     misc_feature    complement(21387..21389)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21965..23110)
                     /locus_tag="FRANCCI3_RS21445"
                     /old_locus_tag="Francci3_4241"
     CDS             complement(21965..23110)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438596.1"
                     /locus_tag="FRANCCI3_RS21445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4241"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_011438596.1"
                     /transl_table=11
                     /translation="MGAADAVRLRAVAALRPARGMPAVTACAVLPRTARGARGRFLITL
                     LALVLATPIVVGAAIGVGSVSVPPGEVWSSVVAHLTGNGAQSSMINDQIIWQVRTPRVL
                     LAFVVGAGLAVAGAVLQAVVRNPLADPYVLGVSSGASVAAVAVLTLGGVSSSGLAAAVG
                     VSGAAFIGAVLTLALVIALGRRRGYLDPQRLLLAGVALTYLFQAGTSYLQLRVGSNQLA
                     AVLFWLLGTVSGAEWDTLGLPACIVVAATLWLLAQARSLNALLLGDEAAASLGIPVSRL
                     RTQLLIVTAALTASVISVAGGVAFVGLIAPHCVRMLIGSDHRRLLPVTALLGGTFLVLA
                     DLLGRVVARPLELPLSIITAVAGVPFFLVLLRRSGRASGAS"
     misc_feature    complement(22565..22567)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23184..23199
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.25"
                     /tool="antismash"
     misc_feature    complement(23186..23200)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.39"
                     /tool="antismash"
     misc_feature    23187..23198
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.88"
                     /tool="antismash"
     misc_feature    complement(23187..23202)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.1"
                     /tool="antismash"
     gene            complement(23309..25243)
                     /locus_tag="FRANCCI3_RS21450"
                     /old_locus_tag="Francci3_4242"
     CDS             complement(23309..25243)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438597.1"
                     /locus_tag="FRANCCI3_RS21450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_4242"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_011438597.1"
                     /transl_table=11
                     /translation="MDSVAGGVPHQEIRSPGIGSRGAGQNGTGLDDVGTAVDNLVSRRV
                     ERHAALRSYLRFVATFKGPALLVVGVFVLSNSLLAVIPVLIGLLVQALASAPVQTHDAY
                     LYAGVLLACNIGHDLTWRGAEVLYLRLLNHRGYEYENILFGNVINERYPYFVGKFTGKI
                     SSYVSTLGREFREILETACFTYVEQLVKVPAILMIMFSVNLYSGLTFLGSVAIMLLVGR
                     HTVRRSARAEKRLADEVSEMDGYVIDVISNFVSVKSFLQEEAEYERVRRRRRQVIAAAY
                     RSSFWSIVFWTSMSLVVRYLVWPVSIVLNLYLFLHGEMSLAQFTTFLSALVLFSDFIWG
                     TVWEIAQLNLRLARIEEAYHYLFAGRNILSAGPDNSASPDNSAGSAGSGRPAVLPAVSG
                     RLQFQGLSFAYPENDRNLVLAGIDLAIERGEKIGIVGRSGSGKTTFIKLLLGYYPLPPG
                     MVAVDGVPVSNRQLARGISYVPQDTTLFHRSIRDNIVYGTAGPVTQAQVEAAALRAHAH
                     SFISRAPDGYDTVVGERGIKLSTGQRQRIAIARAFLDDKPILILDEATSALDSESEVLV
                     QNALENLWRDKTVIAVAHRLSTLLHMDRIVVLDDGRVVEQGSHRELLERRGRYHRLWQR
                     QSGGMIPVE"
ORIGIN
        1 cggcgggcca ccacggtgag ggtggctgcg gtgaggcaac ggggtcccgg taggacgggg
       61 attgcctaga tcaccagccg tagggagccc cgttgccggt ccagtctcgc atgcccgtca
      121 ctcccaccga tctcggacag gccgggtcgg ggcagctggt ccggatgcgg cggtcgctgc
      181 gggtcctggg ggcgcacggc ggtgaggtgc aggggctcgc cgacgtactc gccggggtgc
      241 ctgacccgcg ggacccgcga gggatacgtc accggctccc ggtgatcctg ggactgtccg
      301 ccgcagcggt cgccgcgggg gagaagtcgg tggaggagat cgcggcctgg gctgcgcacg
      361 ccccgacgca ggtcctgacc gctctcgggg cgcgggtcca tccggtgacc gggcagccgc
      421 aggcaccgtc ggtggacacg atgatccggg tcctgtccgc ggtggacagc tcggcgctgg
      481 cgagggcggt cgggatgttc gccgcggccc gcgcccgcca ggcccgtggt ggtgggcggc
      541 gggtggtcgc ggtcgacggg aagaccctgc gtggcgcggc tgggcctgag gggcgggcac
      601 cgcacctgct cgcggtcgcc gaacacggca cgggtgtggt gctcgccgag catgaggtcg
      661 gcgcgaagac gaacgaggtc accgcgttcg caccgctgct ccgcgaactg cattcccatg
      721 atccgctgga tggggtggtg gtgaccgctg atgcgttgca cacgacccgc gcccacgccg
      781 acctgatcgt caccgagctg ggagcgcact tcgtgttcac ggtgaaggcg aacaccccgg
      841 cgttgtcggt cgactgccac caggcgaccg actggacgaa gatcccgatc gggcacagcg
      901 ccgagggcag ggcccatgga cggttcgaac gacgcaccat ccagctggcc caggccagcg
      961 aggcgatccg tgcccgctat ccccatgccc gcaccgtggc gcggatccgc cgtcatgtcc
     1021 ggcggaccgt gaccaccggc acgggccggg cccgggtcac ccggacgatc ccgagcactg
     1081 tcacggtcca cgtcctgacg agcctcaccc tcgacgcggt cacacccgct gatctcgcgg
     1141 gctacgcccg agggcattgg acgatcgaga acaaggtcca ctgggtgcgc gatgtgacgt
     1201 tccgtgagga tgcctcgcgg gttcggaccg gcccactgcc ccgcatcatg accacactcc
     1261 gtaacctgat catcgggctg attcgcctcg ctggccataa ccgcatcgcc ccgaccatcc
     1321 gcagaatccg acacgacaac gccctgctcc tggccatcct cactctcgac aaccccgctg
     1381 acctgcatca atgactttgc gggtcaccct gggtcgccaa gcacaccctg gcccgtctgc
     1441 acaccttcgt ctggtggcgg atgatccgct gggtgatgca ccggcaccgc cggagctgga
     1501 cggccatccg gcgatggctc cggactccgc acggaggacg gaaagacatc gaactggacg
     1561 ggatgacgct gttccacctc ggccaggtgc cgatcacccg ctaccgatac cgaggcggca
     1621 acatccccac cccctggccg gatgccctga caggcccaac cccgacggca tgatcgagtg
     1681 gagagcccgg tgcccggaga cgggcacgcc gggttcggcg ggcggaccgg ggaaacccac
     1741 cgggagcaac cccggcaggg cgccccggtc cgacccaaca acctcgccga ggccgtccgc
     1801 cagaaggtcg ccgcgcacag cacctgccgg gccaaggccg caccaccgcc gatccgcgag
     1861 ggcgcccggg cgataaccac ccgcgaacgc tgggcgcagg tccacaacct gctcgacaag
     1921 ggcgtcggcc tgctggagtg ctcccgccgc ctcggcctca ccctgaacac ggtcacacgc
     1981 tacgcgcgga tcagtgagcc cgagcgtctc atccgggcac cgcagtaccg tcctaccctc
     2041 gtcgacccct agcgcgacca cctacgccag cggcgtgagc aggacccagc agtccccgtt
     2101 ctccgcctgt tcgccgagat caaggatctc ggctacaccg gtaacctcaa cctgctctac
     2161 cggtacatca cccaaggccg ggtcgagtcg gaccggccgg cgatctcgcc acgacgcctt
     2221 acccgccacc tgctcaccgc ccccgaccag ctcaaagacc accagcggga gctgctcgac
     2281 accctcatgg ccgcctgccc ggaaatgacc gcactcgctg ggctcgtacg gtccttcgcg
     2341 gccatgctca cccccgccga cggcaacgcc gaacggctga ccgcctggat cagccaggca
     2401 cggactgaag acctgcccca cctgcacgcc ttcacccgcg gactcgagct ggaccgcgac
     2461 gccgtcaacg ccgccctgac ctgcgcctac cacaacggcg ggaccgaagg cgtcaacacc
     2521 aaaaccaaac tgatcaagcg tcagatgtac ggacgagcag ggttcgcgct cctccgacat
     2581 cggatcttgc tcggctaacg ttgccctccg tcaccaccga atctgcgaca gagccgagaa
     2641 cttgacagca ccgtcgaccg cgatccccgg cctcggccac cgacagccct cacccgtcgg
     2701 gtcgccgggg ccctcggcgg cgacccaggc cgcgaccccg gccaggccgc tctccccaca
     2761 cagcaccgcc gcgcacagcg acagcaccac cggcagccgg tgacgtaccc cgcgcgggtc
     2821 ccgcgggtcc gggatctgct cgaaacattc cgccaccggc ccgcccgccg tggccagcac
     2881 cgccagcgcc tcctgcgctt ccccggccgg gtgggacacc tctgctggct tgcgagactg
     2941 gacgggcaac ggggcctccc gggggtgaga tctaggcaat cccgtcccta ccgggccccg
     3001 ttgcctccat ccccgggaac acgcccacag gccgcccagc gcctcacccc gggacaccca
     3061 accccaccac gatcaccatc agccaccggg gcggcgtcac ctagggcctg ttctgggttc
     3121 ggatcatggg gtcgggaggc tgcgtagcca gaggatggat ccgcgtaggt ggagtcccgc
     3181 ggcgtagctt tcgggtgtct tgtcgtagcg ggtggccaga ccccgccatt ccttgatctt
     3241 gttgatgctg cgctccacgg tgttgcggtc cttgtaaagc gtggcgtcgt ggctgaccgg
     3301 gcggccaccg aggctgccgc gtttcttgcg gttggccttc tggtcggcct tctccgggat
     3361 caccgcctgg atcttccggg cgcgcaggtg ggcgcggttg gcgcgggagg agtacgcctt
     3421 gtcgccggcg accgcgtccg gccgggtcct ggggcgcccg accgggcacc ttgattttct
     3481 tcaggaccag gaggaaacgc gggctgtccg cggcctgtcc gggggtcagg acgatggaca
     3541 gcgggcggca gcgccggtcg gtcgcgaggt gcaccttgct ggtcagcccg ccccggaaac
     3601 gtcccagctc ggcggcggtc agccgagccc tgcggcgtcg gcgtaccgcg cggcgccgtg
     3661 cccgttcggc ttcctcacca ccctcgggcg cctcggtcac acagtcgttt tgcccggttt
     3721 ctgaagcccc ttttcctccg tcagggcctt ctccaggtcg accaggagat ccgggtcgac
     3781 caccatgccc gccgcgtggt gatgcgcgcg ggcgacggtg gagtccacgc tggccaggct
     3841 gagatcgaca tcgtcgcgcg ccgccgcctc ggtgatcatc gcgtccatga gggtctggaa
     3901 gaccccgtcc tgcgcccaca gccggaaccg gtcgtagatc gtcgaccagg agccgtagcg
     3961 ttcgggcacg tcccgccagg gactgccggt ccggaacctc cacatcaccg cgttgacgta
     4021 gctgcgcagg tcagggatca gcccggaggc ccccagcggg aggtacggct cgatcagctc
     4081 ccactcaccg tcggtcaggt cgccacgagt catacaaccg tgctaccagc cggagcaccc
     4141 gaacacgaaa ggcgatcatc ccgcctgtga tccgaacccg gaacaggctc tagcaggact
     4201 tcgttaggtg actccggata ggtgactccg gataggtgtt gtgtgacggt gggtgtgtgg
     4261 gtgaagggtc gttggcaggt ggggcaggcg ccggtccaga cggcgagcag ggcctggagg
     4321 gtgcggagga ctccgtagag ggtcaggccg gcgcagggac ttttggggtt cgtctcagct
     4381 gggtgcagag ggcttgggcg accctgacga gggtgacgtg acggtgccag ccggcgaagg
     4441 ttcggccctc gaagtggtcg aggccgaggc cgtctttcaa ctcgcggtag tcgtgttcga
     4501 tccgccagcg gatcttcgcg agacgaacaa gatcgcgcag ggggatgccg gtgggcaggg
     4561 tggacagcca gtaatcggtg ggttcgggct ggccgactgg ccattcggcg agcagccagc
     4621 agacgggcag gctccggtcg gggttacggg tgatgttccg gcccgcgggg cggacccgga
     4681 gcgcgaggaa gcgggaccgc atccccgcgg tcgggttggc cggggtccgg tgggtgccgt
     4741 gacgccaggt cacagaccgg cccgtgcggc ggccggcggc catgaccagg gatttcagat
     4801 cgcggggcgg gtcggggtag gcgggtgtgg gccgccggct gtttcccggg tagggggcgg
     4861 tgaccggcac cgcgtcggcc gggtaggcgg tcgcggtcgg cttcaccgcc agcacgtagg
     4921 ggatgttccg gtcggtcagc ccctggcgga aggcagcggc gtcgccgtag ccggcgtccg
     4981 ccacgaccgg ccgcacaggc atgccccagc cggccagttc gtcgatcatg tccaggacga
     5041 gccgccattt ctcccggtgc cgcgccttgt cggggatcgc ggcccgttcc cgggcccggg
     5101 cggcggcgac ctcggtcggg tcggtcaggg tggtgtcgtc ccagcaggtc gggaggaaca
     5161 gccgccaggc caccgcggcc gacgcccagt cggtgaccgc gtgcacggac accccgatct
     5221 gacagttccc gaccttgccc agggtgccgg agtacatccg ggccaccccg ggggaggcgg
     5281 cccgtccttc gggaaagccg gtgtcgtcca cgaccagcgc gaccgggtcg cagaacccgg
     5341 ccgcccagcc cgtcagccgc cgccggacct ggcggtagtc ccaggtcgag ctggtgacga
     5401 actgctgcag ctgctgaggg tccacaccga ggcgggcggc catcgggacc atgctcttgc
     5461 gcttgccgtc ggtcagcagc cgttgcacgt acagctcacc cttaccccgc tggtcccgcc
     5521 ggggcaggtc cgcgaacatc tcacccgcaa accgctcgat caccggacgt acccggccca
     5581 tctcacccag ttccatacca accaccgcca cacgcatgaa gacgacagtc agtacaacca
     5641 cagacagacc taatcaagtc ctactaggta cctggtcggt cgaccagatg gcggcgttca
     5701 gcgcggcggc ccatccgctg accgccgcgc tctccctcgt ctccggcgga acccacgcct
     5761 gagccggcca tccggcgagc cgaccctccg tcctgttccg gagggcatcc tgttccggag
     5821 gggttgccgt gccggcgctg acgcccgggg ccaccgaacc gcggatggtc ccggacgccg
     5881 cgcgaccgtc cgccgccggc cccgacccgg gggtccgtgg cgacgacgac accgcgacgc
     5941 gggtggcagg agcacggcgt cagtccacgg caccccgccg cgtcacggca tcccggacat
     6001 ggtcgatgac cgaggcgatc ggacctaccg tccactgctt ggcggtcgaa ccggcggctg
     6061 acgggtgcgg atgggtggga gcgaacttct ccgccgtccg aagccgacgg cccatgcttt
     6121 ccagctgcct ggcgtcgcgg gccgcgtgca cccgggggaa ctcctcgttt tcctcatgct
     6181 cggcatggtc gacaacggcc cgttcgaagt ccgccagctt cgcatcgaac tcggcgctac
     6241 cgacatccat cttctccagc gccagcagca cgcgggtggc ctcgtcctcc tcgtggttgc
     6301 gcgcctcggc cacccggctg tcgatcttct tcgtaaccgg ccgcacgacc atctcctcgg
     6361 cggtctcgtg cgcggcgagc aacgcccgca gctcgtcgaa cgcccggcgc ttgtgctcgc
     6421 ccgccgccga cttcacgtcc gcgaacagct cgcggatgcg ggcgtgctgt tcgagcagga
     6481 ctcccacgac gtcgtcgtgg gagaactgcg ccgctcggcc gccgtcgaac ccagcgtcat
     6541 tgatcggcat gatgtcctcc tcatcacggt ccgcccatcg agacctcgat gtcggcgtgc
     6601 cccgagacgg cactcgaaat cgcgcggcat cgaggacgcc cgaccggcgg ggcccaaccg
     6661 gcacgttggg ctcgtcaacc tgccccggcc ggatcggggt accgagagtg ccccgatccg
     6721 gccggggcag ctcgccgcct accgacgtcc ccaatcaggg ccagtacgaa gtagccacct
     6781 aaacggcccc atgagtagct cataattcct agtaacccgt cggcgcgatg acggtgagtt
     6841 gatgcctggg agcacctgcg ccgtccggtc acgccgcacc ggtcacgccg accggcgcgt
     6901 acgacggaat aacgccgata ccctcccaaa gacacgtata gtgataattc ctggcgtcca
     6961 ggcttgagtc gaagcttgaa ccgaaggcga ccggccgagg catgcccctc gcatcgcggg
     7021 attcggccgg cgccgttgcc gggaggcaat ggctccctcg gtcggcagga ccggctcgat
     7081 acgatgcgcc tcgggtcgat catccgacca gccgtgccgg gcggacggat accccttttc
     7141 ggccatagcc acaggtcccg caatggccac aggtcccgca atctccaggc ctttggcccc
     7201 gccggggccg ctgggccgct gggccgccgc atccggcgga tgatcggacc aggccgcggt
     7261 tgcgggcccg ggacgggcac tcgggccgag gccctgacca ggagaagcgg tcagcgtcta
     7321 cggcgtgtcg tgagaagtcc gcaaccggtc cggatctgcc gcggacgggc cggcgcggca
     7381 ggtctggacc gggtgggacg ccacgcgccg tctccgtccc cgtcgccgtg acgtttccgg
     7441 cccaccgcag ggggtgaaga aatacccgca cgccgcactc gagggagacg acggcgctcc
     7501 cacccgggtt ccccggaaat tggctatgtt ccgcggcgcg aacgaatatc accgaaggaa
     7561 ttttgcgcgc ggactccgcg aacgctccga ccgccagccg gaccagattt cgacccgata
     7621 tcaccacggt cgggacacgg gcgccgatcg gcgcttgatc caccggcgga ctggatcaac
     7681 cagcggaaaa ggaggacggt actcctgtcc gccgcgtacc gacagttcgt ccgggacacc
     7741 gggaaaacga tcgagaaaac gcctggccgc cctttacggt gcgtggtcgc cgggccgggc
     7801 cgaggactag agcaggccgg tctgcccgga ccagatctga ttggttccgc aaagtgcttg
     7861 ccgcccgtgg gatcgatgcg ggaggcttcc catgcgcggc gagacgacgc gcgttccgtt
     7921 cgagacaagc gcaggtctcc tgttgactcg acgccatggg gggggttaca ccaacggagc
     7981 gcccatagat gtcatcgcta ctcagggaag gcgggactca cccagcgcag catcggaact
     8041 tcgacgtccc gcatttcgtg tcggttcgat gtacctgcgg tcggcggcca gccgccggga
     8101 tccgtcacgc ccgcacattc ctatgaccgt gcacaggccg cgccttctac atgtgcgtcg
     8161 ggtcaataga aaccgcactc cgggaaaacc cccatacccc cagtgtaaac ccccactccc
     8221 agtgggaaaa ctgcccctgc gaaaaccaga gataggtgga gtctgtcatg accgaacccg
     8281 tgcaggccgg tacggatgcc ggcggcgaag agccccggct gagtctgagc acggcggccg
     8341 cgcgcaatct cgcgacgacc accaagtccg ttccgcagat gcaggagatc acctcccggt
     8401 ggctgctgcg gatactgcca tgggtccagg cgtccggcgg cgtgtaccgg gtcaaccgcc
     8461 gtctgaccta cgtactcggg gacggactcc tcacgttcac gaccaccgga tccgaggtcc
     8521 gggtcgttcc gcgcgaactc ggcgagctgc ccgccctgcg gggcttcgac ggcgaggtgc
     8581 tcgatgcgct cgcggaccgc ttcgcccaac gggaattcgc tgccggagac gtgctggtgg
     8641 agagcggtca ggccgccgac caggtgttcc tgatcgcgca cggtaaggtc ggcaggttcg
     8701 gcctcggaga gtacggcgac gagcgggaac tcggcgtact cgccgacggc gagtacttcg
     8761 gtgacgaggc gctggtcgag gaggacctga cctgggagtt cacggcccgc gcactcaccg
     8821 gtacgacggc cctcgtcctg tcgcgccagc agttctccga actcgccgac tcctccgacg
     8881 agctgcggcg tcacctcgac gagtaccgga cccggctcca gcccccgagc aaccgcctgg
     8941 gcgaagcgga gatcgcgatc gccgccgggc acaccgggga accggacctg ccggggacgt
     9001 tcgtcgacta cgaactggcc ccccgcgagt acgagctcag cgtcgcccag accgtgctac
     9061 gcatccacag ccgggtggcg gacctctaca acgaaccgca caaccagctg gagcaccaga
     9121 tccggctcac cgtcgaggcc ctgcgcgaac gccaggagca cgaactggtg aacaaccccg
     9181 acttcgggct gctgcacaac gccgacctcc gtcagcgtat tcacacccgg agcggtccgc
     9241 ctaccccgga tgatctcgac gacctgctga gccgccgacg cagcacacat ttcctgctcg
     9301 cccacccgcg gaccatcgcc gcgttcggcc gggaatgcac cgcccgtggc atctacccgg
     9361 ccaccgtcct cctccacgac cagcacgtgc cggcctggcg tggcgttccc ctgctcccgt
     9421 tgaacaagat tccgatcagc gggaccggta ccacgtccat cctcgcgctg cgcaccggtg
     9481 aggagaacca gggggtgatc ggcctgcacc acgccggcct gccggacgaa tacgagcccg
     9541 gcctgtccgt gagattcgcg ggtatcagcg acaaggccat catctcgtac ctggtgacca
     9601 cgtactactc cgcggcggtg ctcgtccccg acgcgctcgg tatcctggag aacgtcgaga
     9661 tcggtcggtg acacccggcc gcgcgagccg ctgggaccac ccggaacccg cggaattacg
     9721 cggaattacg cgagatcaca tgagatcaca tgagatcacg ctgggttccg gaagggttcc
     9781 gcggggctcc gcggggctcc gcggcatccc ggcccgatct ctcccggccg ccccgaacgt
     9841 tcacttctcc gctgccacct cggcagaccc ggtgcacctt ccccggggcc ggttccccgg
     9901 ggaaggtgca ccggtgccgg atacggataa ggatccgtat ccggccgact ttcggggccg
     9961 gccgtccagc ccgtgaccga gaagggttca ccagcgggtc atgcagcctt tcacgctacc
    10021 ggagttctac gtgccctatc cggcacggct caatccgaac ctggaacagg cccgcgtgca
    10081 cagcagggct tgggccgacg agatggagat gatcgactct ccgcagcacg gaaccgcgat
    10141 ctggaccgag gccgacttcg acgcacacga ctacgccctg ctctgtgcat acacccatcc
    10201 ggactccgtc agccgaaaac tcgatctggt caccgactgg tatgtctggg ttttctactt
    10261 cgacgaccac ttcctggagc tgtacaagcg gtcccacgac atggccggcg cccgggccta
    10321 cctcgaccgc ctgcccgcct tcatgcccgt cgacggtgag atcaccgaga cgccgaccaa
    10381 cccggtggaa cgcggactcg ccgacctgtg gacccggacc gtcccggagc gttccgccga
    10441 ctggcggcgg cggttcgcgg tcagcaccaa gaacctgctg gacgagtccc tgtgggaact
    10501 agccaacatc aacgccggca ggctcgccaa cccgatcgaa tacgtcgaga tgcggcgcaa
    10561 ggtcggcggc gcgccctggt cggcgaacct cgtcgagcac gccgccgacg ccgaggtgcc
    10621 ggcccaggtc gcggcgaccc ggccgctgca ggtactgcgg gacaccttcg ccgacgccgt
    10681 gcatctgcgc aacgacctgt tctcctacca gcgcgaggtc gaagaggagg gcgagctcag
    10741 caacggcgtg ctcgtcatcg aacgtttcct cggctgtgga acccaggagg ccgccgacac
    10801 ggtcaacgac ctgctcacct cgcggctgca ccagttcgag cacaccgcgg tcaccgaact
    10861 gccggcggtc ctcgaggagc acggtgtcga cccggggagc cggctggagg tcctggcgta
    10921 cgtgaagggt ctgcaggact ggcagtcagg gggccacgaa tggcacctgc gctcgagccg
    10981 gtacatgaac cgggccgtgg cgcctgagag cggcgagctc agcggactcc tcggactcac
    11041 cggtctcggt acctcggcgg cccggattgt gccgtccctc gtcaccacca caccgcgccg
    11101 gatccgctcc ttcacgcaca tcccgcacca gatcgtcggg ccgctgcgcc atcccgactt
    11161 ctgcatgccc ttctcgaccg ggcagagccc acatctggac gcctcccgcc gggaaaacat
    11221 catctgggcc cgggcggtag ggatgctgga cccgattccg ggcatctggg acgaacacaa
    11281 actgcgggcg ttcgacttcg cgctgtgctc ggccggaatc catccggacg cgaccctgcc
    11341 ggaactgaat ctgacgacgg actggctcac ctgggggacc tacgccgacg actactaccc
    11401 ggtaatcttc ggccgcaccc gggacatcct cggggccaag gtgtgcaacg cccggctgtc
    11461 ggagttcatg ccgctggact cccccgtcac cgcggtgccg gccaacgcgt tggaacgcgg
    11521 tctggccgac ctgtggacgc gcaccaccga gaccatggcg ccaggcgcgc gcgagacgtt
    11581 ccgcggcacc gtcgaggtta tgatcgacag ctggctgtgg gagctggcaa accaggccca
    11641 gaatcgcatt cccgacccga tcgactacat tgagatgcgc cgggcgacct tcggttcgga
    11701 tctgacgatg agcctggccc ggctggcccg gctggcccag gaacagaccg tgccacccga
    11761 gatctaccgc acccggccga tccaggcctt ggagaacgcg gccgcggact acgcctgtct
    11821 cctcaacgac gtcttctcct atcagaagga gatccagttc gagggtgaga tccacaactg
    11881 tgtcctcgtc gtcgagaact tcctcgactg cgaccgggag cgtgccctcg cggtggtcaa
    11941 cgatctgatg acctcccgga tacgccagtt cgagcacatc gtggcgcacg agcttccggc
    12001 gctgttcgac agcttcgccc tggacgcgtc ggcgcggcag gcgctgctgg gctacgcgcg
    12061 ggaactccag aactggctgg ccgggatcct ccgctggcat gagggcacgc atcggtacga
    12121 ggagtccgaa ctgcggtacc acccagcggc gggagtacgg cccttcggcg gccccacggg
    12181 cctgggcacc tcgtccgccc acgtccgccc acgtccggcc gcggcggccg gcgcggccgg
    12241 cgatagtgaa atgtagtcag ctcgcatgcc tggttggcgg tcggaccggc tggcggccga
    12301 cggggaacac gacggtcggg aacatcgtgt cgggcagacg cagcaactcg gcgagggcct
    12361 ggtcgtcgaa ggccgtcacg gcgcatccgg ccagcccgag tgcggccgcg accaggtaga
    12421 ggttctgcac ggcgattccc gcgtcgaggt gcagggtgcg gtaatggcgt gccgggtact
    12481 tcacgagagt cgtgtcgagc cgggcgacta cgacgaccgc catgggcgcc cgttcggcga
    12541 actcgggttg gaccagcacc gaacgcaacg ccgccgtcgg ctcgccggac cgcaacgtct
    12601 gcaggcagtg gtcctcggcg tcgtaccgga acacgccgcc gggcagctgc gcaccgcgcg
    12661 caatgacgag atagatggac agtgaatgca ggccacctgc cgacggcgcc atccacatcc
    12721 ggtgctgact gccgtcgggc agtcggacat cccgctgcgg acccaccgcc cagcgtagga
    12781 gcgaggagac attctcggcg gtcggcgcct cggcatcgaa ccggtaccag gacctgcgtg
    12841 ccgcgagcac ctggccgaac tcgaccggca ggtccgcgcg cggtgccggc agcggaatcc
    12901 ggcaggtggc ggcgcgcagt ccgtcgagca tcacctgccg ggtcggcgga ccattgagga
    12961 cctgttggac ccgccggata cgctccagcg cggtgacgtc ctcggccaca ctcgtccctt
    13021 cggttacgtc gctaatgcgc taatgcggca gcgggaggtc gcgccgggtg gtgcccgccg
    13081 cggcgagttg cctggccagc cgggcgccgc cgaggaacgg aaggccgaca gaggtgttcg
    13141 agtacaggcc gggggccaag gtgtgcacga cccgcatgcc ggtggggcgc acgtcttcgg
    13201 tggtgacgtc gaccgatgtc accgggtggc cggcgtcggc gagcgtgcgc gcgagcaccg
    13261 tcgggtcgtc gactccggcg tgccgggcgt cccggtcgag ggtctcccag ccgatcgtgc
    13321 cggtgagggc ctcggcgagt tcggcctcca gccggtcctg caggcgagag tcgaggaaga
    13381 gctggaggtg ggtgcagtac tcgacgacgt ccgccaggtc gtctcggcag tcgtcgaggt
    13441 accgtcggtc agctcgccac ggcttgaggg ggctgtgcgg gttgcgtgcg gcgcgcatgt
    13501 aggggccgtc ggagtcgtcg aggtcggcga cgaacatctg cagctggaag gcttcggcaa
    13561 gggccttgcg cagcgccggc gtggtggtgg tccggcacgc tgctcccatg gtcaggtagc
    13621 cggtcgccgt gtcgtgcacc agggcgccga cgacgacgag gccgaactcg ttcgggaatt
    13681 cgacgaaccg ggtcgtcatg cttccgtacg cgcccatggc aagctgcgcg atccaggggg
    13741 gcggggtgat ggcccgcagc ggccggcggc cgtgccaggc catggtcagc gtgtcacgtt
    13801 cgatcatctg gcagatcgcc gaccattgcg ccgagcgctg gtccataccg gcggccaggc
    13861 cggcgctgag gaccgggctg aggtagggga acccgcgggc ctgggcctgg tgggcgtagg
    13921 acacccagac gagctgcgcg ggtacccaga cgggggtgcc agcaagcagg tcggtgccgg
    13981 acgtccattc cagctcgaga tcctcgcggt actcggtgaa cgggaagtag ggcccggcgt
    14041 actgggcggg tgagtacagc accaccgagc gcgggtcaag cacggtggcg cggtccgccg
    14101 tgagctcttt gtgggtggcg cggcgcagtc cggcggggac gaggttcccg cagtagcgtt
    14161 cgacggcctc gccgacggcg ggcccgaggg cggcgtcgtc gtcgagcagg gcgtagccgg
    14221 ctccggcgaa gtcactggcc caggcggaga acctggtggt gtcggagaga acggcggtgt
    14281 acatggtgaa ttcgggcggc agggtggcgg gaatggcgtt gcgttcgatc cggcggatga
    14341 tcccggttcg gggggcgagg atcgcggcga ggtccatggg tgctcctcag acgtgcggga
    14401 tcgggtacgg ataaagggcg tcttcggtga tctttccggc agccaggccc agctgggcgg
    14461 gtacgtcgta gagccgctcg ccgccgagga acgggaaggc cgcgggcggg ttgccgtaga
    14521 gcccggggac gatgacccgc acgacggtga ggccggccgc ccgcacgtcc ggagtggtga
    14581 cgtccactga cacggcggac aggccctgcg tcgcgagcat gtcgaggtag cgtcgatggg
    14641 ctgtgccccc gttggcgtcc ccgtcggccc gggggatgtc ggcgagccgg gtggtgcggg
    14701 tgtcgtcgcg gagccggtcg aggggccggc cctgcattcg tggatccaga tagagctggg
    14761 cgaccgcggg caggtcgacg aggtcgcgga aatccggccg gatgtcatcc gcgtaccgcc
    14821 ggtcggcgcg gtagggcagg tacgtgtgcg ggggtatctc gccgcgggcg acggctcgcc
    14881 agtgcgcgct gtcaccgtcc gcgagctcgg cggtcagttc cagcatggcg aaggcttcga
    14941 cgagcgcctt cgtcgccgct tcccgcggat ccgcccggca tgccgtgccg tacgcgatca
    15001 acccccgtcc cggttcttca aggaaggcgg cgagcaccgg aaccgggaac tggcttggca
    15061 cctggaacaa ccggatggtg cgaccggtgc cctctccgtg ggcgatgtcg taccggtcga
    15121 ggagctcagc cgcatcggcg acggcccagc cggcggcgcc gctggcccac cagatggtgt
    15181 tcgcgtcgcg ttcgaagagc tcttccaacg caaaacgctc ggcgtgctca cggttctcgc
    15241 cagtggcgat gccggcgtac agcatggcgt gggtggccac ctcgtcggcg tgcgcgccgc
    15301 ggaagtagtt caggtaggcc atcgacgcgg gcaccagcac cggacccccg gcgtacaggt
    15361 cgcggccggg cacccaggcc accggtgtct ggcgggtgaa gggccggaag gggaacccgc
    15421 gggcgcggta ctgccggtcg gaatagagcg ccagggtcgc cgggtcgaga gccggccgcc
    15481 cggccctggc gagatcgtcg tagcaggcga tctccagggc gtcgggaacg gcgttgccgc
    15541 agtaccgttc cacggcctcc ccgaccgcgg cacggcgcgc ccggtcgtga tcgcccaggg
    15601 cggcaccgaa gccaaaccgc tcggccgacc aggtggcgaa cgcacgggtg tcggcggcac
    15661 gggcgctcca gccgacccag caacgcggca tggcggggct cggctggtag ggaacgatct
    15721 gggtgaggac gccgagtcgg cggtcgacga gacgccgttc ggccggcgcg ggggtggttg
    15781 atctcacggg tgctccagca cgggcaggtc gacccggcag ccgcgggttg gaccggtgtg
    15841 gatggtctgg gtggcgatcc gggtggcgct ggtggtgtac cggtcctggc cggtgttggg
    15901 ggtgcgggcc agccgcggga agtcgctgct ggtgacctgc agctccagcc ggctgccggg
    15961 gtggagcagc agggccgtgg cgccgagcgg gatcgacacc gtggccgcgc cgggcccgac
    16021 ggcagcggcg ccgctggtga cctccaaggc ccggccgtca ccgagccgct ccaccagccg
    16081 gactatccag tcggtgccgg ggcccgtggt gtctgcggcc atcgtgacgg tgggtgcgcc
    16141 gacgatggca gtcggcgtcg tcagtggcgg ggtccggaat gccacggcgt cggcgcgggc
    16201 gtccaggggg gcacggtcgc agtcccgcgg gaggctgggg aaggggtcga gcgggtcgta
    16261 ggtgaaccgg tgctcggcgg gccgctcggg cgggttcggc aggagtgacc cgtcagcgct
    16321 ggcctgcagg cccagggtgg cggtggacgc cggccaccga tccagccagc gtccgccctc
    16381 gacgaggaac accttggtga tcgacgcatc ccggccggcc agcacgtcaa agatccacgc
    16441 gacctggagg cgtcccagcg gcagttgcga ggcgggcccg tgctcccgcc cacccgccga
    16501 gctggaagcg ggggtcgaca gctcgtgccc ccacggcccg atcaccaggc cccgggcggg
    16561 cctgttcgga gcgcggtcgc ggcccgcggt ttcccactgc cacagcgtct gtggcaggaa
    16621 gagatcgtac cagccgccga tgtgcaggga cggcagcgag cagcgggcca gttcctgcgt
    16681 gctgatgccc tccccgaggt cgtcgccagt acggtcatgc ggtgccgggc tgtcgccggt
    16741 cgtcaacgga gccggggctg acagagccgg ggctgacaga gccggggcta tggcgctcca
    16801 ccagcgtggc acccgtgccc agaggtgccg gccgaggtca gctaccggca ggtgccgcag
    16861 caggtccggc tcacagccca gcatctgcgc ggacagcccg ttcctgctgg tgcggctctc
    16921 ggcgtgctcg gcccaccagc cggcgtactc ggccagccgc aggatccccg acgggtccac
    16981 gttggcgggc cgcagacccg cggcgggtac ctcgctgatc actgcgcgca cgagctcggg
    17041 aacggtgacg gcggctgccc acgcggtgaa cgagccgtag gaggctccgg cgaggatcac
    17101 gttcccatcg caccagggct ggcggtggac ccattcgacc aacgcccggc catcggcgcg
    17161 ctccccttga tacggggtcc aggttccgcc cgacccatag cgcccccgca cgtcctgggc
    17221 aacgtaggcc agtccgttcc gcgcccaccc gacgccgttt gccagcagcg aaccgcgacc
    17281 gtacggggtg cgagtgacca ccgccggggc gggtagccgg tcgggacggt agacgtcggt
    17341 cgccagcagg acgccgtccg ccgccggtac ggcctggttc gcgtcgatgg cgtgcatgcc
    17401 ccggcgccta gaccgggttg accgcgaggt tgggaagagg aagcaccgga tgccggctga
    17461 tcgacgccgt ggtcggatcg acgacgagct ggtgcccctc gctgggcacg gtgcttcccg
    17521 ccgccagcgc ccgcaggtcg gcggcgagca gccccgccag caccgcggtg gctgccgggg
    17581 tgaacggtgc cggcggcttg accgcgtcgg aatcgaggta agcccagtgg gcgatcagct
    17641 cgtcggggag agcggccgcg gcgagccgac gtcctctggt gtcccggtag cacgccgtac
    17701 ggcccggcat cgacaggggt cccacgacga acgtgtcgcc ctcggcgtag cagccgtgcc
    17761 atggcgtgtg gtgcgccgcg caccactgat cgagccggca ccagtgcgag tccggcagcc
    17821 accgggcgca gctgacgacg gcgtccgagc cggctaccgc ggcctcgtcc gccgggccca
    17881 cggtgcactc gacgtcatcg atgatgtcgc ccaggagttc ggtgagcttc ccgacgaccg
    17941 gactgtcgcc gtcgaggtgc accttccagc cagccggaac ggtccccgca cgccccgggc
    18001 cgacgaacac gccgcgatcg gtgagcgcgg cggtcatgcg ctcgacggcg ggtcggtccg
    18061 catcgggcag gggcagctgg gtggccccgg ccgcgacgtt ccgcacgagg gcgagcaggc
    18121 ggtcctcgcc gccaattcgg acgaagacgt ccccgggggc gctgtaacgc caactcccgt
    18181 cggcggcccg gtagagatgg tggccaggag agaacacgtc ggctttcctc atcgggtgtg
    18241 tcgcggtcgt gatgggctgg tcgtgatggg ctggtcgtga tgggctggtc gtgatgggct
    18301 ggttgcggcc ggcaggggtc atggccggca cgggtcgcgc gcgggccggg atgaacccgg
    18361 tagagaccgt gaccgtcgag gacgtccgag aaactgacgg caccgacggt cacggcttgc
    18421 actggctcac caaggtgcgc tcggcgcctt cagtgaaccg gcggcactac tcctcgtcgt
    18481 cccacgcgaa cgggctctgg acgagcgcgt gcgtggtcgg gtcctgcggg gcagcgagga
    18541 ccggcgcctc ggccagctcc tcgaacgaga tctccgccat gcttcacctc cttcgcaata
    18601 aaacggtttt cgttttcaaa aggaacgcta gcacgagcga cgtggggatg ggctgatatc
    18661 cacacatccg ccgggcggct cgttcggggg ctcattcggc ggctgtcacc gcccggaccg
    18721 cggcgtccgg cccaccgggc ccggcctgcg gcgggttggc cggtgcctcg tcggccctga
    18781 tcaggtcctg aagcctgccg gtgtggccga ggcctgccat caggcccgct accagcgcca
    18841 ggccgacgcc ggccgaggcg gtcagcagag cggcccgggt gccccaggca tcggcgagga
    18901 tgccggcgag cacggcaccc agcggcgttc cgccccaggc gatcatcctc gcggtggtgt
    18961 tgacccgggc ctgcaggcgt aggggggtga cggcttgccg gacgacgatg ccgtttagga
    19021 tgaccaggga ggtgctggcc tgccagagca gcaggatgcc catccctggc agccacgccg
    19081 tgttcagaga ccagccgatc agggcgagcg tgctggctcc gagcgcaccg agtgtgatcg
    19141 ttccggtggg gacgtgtcgg tgcacgcggc tgagcagctg gctgacgatc agcgttccga
    19201 gcgcggcggc gacgtagagg agaccgatcc gcgggtcgtc gtcgggaagg ccgaactgcc
    19261 gtaccgcgac gacgacgacc aggccggtga ccgcgccccc ggacaggctg ctgccggccc
    19321 cgagcagggt cagagtccgg atgaggcgat gcccccggat gtaacccagg ccctcggcga
    19381 tgtcgcgacg ggtccggctc acccggctgc cagccggccc gctccggtcg gccctgctcc
    19441 ggtcggctgc ggccggcacg gcccagcgcg cccgggagag caggatggca ccgaccaggt
    19501 agctgagcgc atcgagggcg agcacactgg ctgcgcccac cgtggccgcg gccaccccgc
    19561 cgacggccgg cccgaccagg ttgacaacgg tgctcaccga caccatcgcc ccggtcgccg
    19621 cggccaccgc gtcccgtccc acgatcgccg ggactgcgcc gaagctggcc gcatcgaaga
    19681 acacgaagac cgatgcgaca agcaccgcgg agatcagcag atggggtgtg gtgaggacac
    19741 ccgcccagtt ggccacgggg atgctggcca tcgtcaggcc gctgaggcaa ctggtgacca
    19801 ccatcgtgcg ccggtgatcc cagcggtcga ccagggcacc agcgggcagt ccgagcacga
    19861 ggtagggcac cgcttcgaga ccgaccagca cgcccgcgag cgtgccgctc ccggtgcgct
    19921 ggaaaagcag caccgggagc gcgacgagcg tcatcgccga acccgcccag gagacagccc
    19981 ggctcgccag gaaaagccgg aaggcgggta ccgtactcat ctcaggttgt tactcatctc
    20041 aggtcgtccc acattccaca tttttgggtc tgcggctcag gcgtgcagcg cggcggccag
    20101 ctttgtcacg ccttccacgc cggcgaggtt ggccgagtcc gactgcggga ggaagaacac
    20161 acggttgttg cggactgccg ccacggtcgg gagccgggag gtgaggaact tgcgggcctc
    20221 ggcctcggtt tcgctgccgc tgagcagata gacgagggtg ccgggattct tgctgatgag
    20281 gtcctccacc gacagctcac tgaagtattt gcccttgggc agggtgcccg cgtagatgtt
    20341 ccgcgccccg gcgagccgcg cgatgtcggt gtagacgccg tcgtaggtgt agacggttcc
    20401 ctggtaggtg gcgaccaccg cgaccgggac ggggtccctg ccctggatct tcgtcgcgac
    20461 ctggcggagc cgttcgttga tgtcggcctg gacctgcctg gcccggcccg gaatgccgaa
    20521 gatcatgccg agcgcggtca ggtcggtatc gacgtcacgg accgtcgcct tggtggcgtc
    20581 gtcggtgcag aacccgctga gaatcatcac ctgggtgccc tgggcggcca gctcggcgat
    20641 cgtggggagc tgccggccgt caaacagata gctgccatcc gcccagatca ggtcgggccg
    20701 ggcggcgagc agcgcctccc gggtcggtgc gccggtaccg agggcgggta gcttcgcctc
    20761 cacactggcg tacttcgccg ccggtgtgcc gctgctggtg ttgtactggc caacaatccg
    20821 gtccgtcagg cccagttcga tgaggagctc ggtactggtg gtccacccgg agacgacccg
    20881 cgccggggcc tcgtcgaagt gcagggtccg gccgcagttc gccacctcaa cgggatagcg
    20941 ggtaccggcc ggggccgacc gggcatcggc cgcgctcgca ctgcccgcgc cggtggtcga
    21001 accggacccg cagccggtga gaccggcggt aacaacgagc agggcagcga ccgcgacgcc
    21061 ggcgccgagt ttcttcatcg ggttctgtct ccttccattg cttcatcggg tcattgcttt
    21121 atcgggattt ccgcgccagc taccaccggg gccggctcgt ctgttccggg caggctggaa
    21181 gaaggcaggc tggggaaggg aagactggag aaagcgagct ggaggcggcc ggtcaccggg
    21241 tggacgctcc ggtcggcgcg caccccgaac acgcggccga tgaggtcggc ggtcaggacg
    21301 tcctccggtt tgcccgaaca gatcaccgcg ccgtcgtgca ggacatagag ccggtcacag
    21361 aaggccgtcg cgaggttgag gtcatgtaac gcggcgagca cggtgatccc gagtgagcgc
    21421 accaactcca gcaggctcag ctgggtgctg atatccagat ggttggtcgg ctcgtccagg
    21481 atcagcaccg acggtgcctg cacgagggcg cgcgccagca ggacccgctg cttctcgccg
    21541 ccggacagcg acgcgaacgc ccgcccggcg tgcgcggcca tgcccacggt gtcgagcgcg
    21601 gccgagatga tctcatgatc cccggtcgag gtcgggctcc acgcgctctg gtggggggtc
    21661 cgcccggtcg cgaccacctc aaggacggtg aagtcaaagc catcggggct ttcctgcgcc
    21721 agggccgcga cccgccgcgc cgactggcgc ggggtgaggt ccctgaccag gtcagttccg
    21781 tcgagcagca ccgcaccgga cgtcggccgc accacccggt agaccgtctt cagcacggtc
    21841 gacttcccgc tgccgttcgg accgaccagg ccgacgaagg cgccgggggg acagccgacc
    21901 gtcaggtcgc gcacgatctg taccccgtcg gcgacgacac ccagaccttc caggcgaagg
    21961 cccgtcacga ggcaccactc gcccgtcccg accggcgcag cagcacgagg aagaagggca
    22021 ccccggcgac cgcggtgata atgctcaacg gcagctccaa cggccgggcc acgacccggc
    22081 cgaggagatc ggccagcacg aggaacgttc cgcccagcag cgccgttacc gggagcagcc
    22141 gccggtggtc cgacccgata agcatccgca cgcagtgcgg cgcaatgagg ccgacgaacg
    22201 cgacaccgcc ggcgacggag atgacggacg ctgtcagagc ggcggtgacg atcagcagct
    22261 gggtccgcag ccggctgacc gggatcccca gcgaggcggc ggcctcatca ccgagcagca
    22321 aggcattcaa cgaccgggcc tgcgccagca gccacagcgt cgcggccacg acgatgcacg
    22381 cgggcagccc cagtgtgtcc cactcggccc ccgacaccgt tcccagcagc cagaacagca
    22441 ccgcggcgag ttggttcgag ccgacccgca actgcaggta gctggtgcca gcctggaaca
    22501 gataggtcag cgccaccccc gcgagcagca gccgttgcgg gtccaggtaa ccgcgcctac
    22561 gccctaacgc gatcacgaga gccagggtga gaacggcacc gatgaacgcc gcccccgaca
    22621 cccccaccgc cgcggcaagc cccgacgacg agacccctcc cagggtgagg acagcgaccg
    22681 cggcgacgga ggcacccgag gacacgccca gcacatacgg atcggcgagg gggttacgca
    22741 ccaccgcctg cagcacggct ccggccacgg ccaggcccgc acccaccacg aacgccagca
    22801 acacccgcgg cgtccgcacc tgccagataa tctgatcgtt gatcatcgag gactgagcac
    22861 cgttgccggt cagatgagcc acgacgctgg accacacctc accgggaggc accgataccg
    22921 aacccacgcc gatcgctgcc ccaacaacga tcggtgtcgc cagcaccagg gcgagcagag
    22981 tgatcaagaa tctgccgcgc gcgccgcgcg ccgtgcgcgg cagcacggcg caggcagtga
    23041 ccgcgggcat cccgcgggcg ggtcgaagcg ccgccaccgc ccgcagccgt accgcgtccg
    23101 cggcacccac ggatggcgtc ggcgtggcac gtaccgacgt aggttgatcg atggacagcg
    23161 gatgcccccg ttgactcaaa cgaaacgaaa acgattttcg tttcgtttgg gcaagctaac
    23221 agccctgcgc gggctccgtc aacggttctg tagggggcag gagaggatac ccgctcgtcg
    23281 tggtcgggtg gtcaccatca tccggcgact actcgaccgg gatcattcct ccgctctgcc
    23341 gctgccacag ccggtggtag cgcccccgcc gctcgagcag ctcgcgatgg gacccctgct
    23401 ccacgacgcg gccgtcgtcg aggacgacga tgcggtccat gtgcagcagg gtcgacagcc
    23461 ggtgcgcgac ggcgatcacc gtcttgtctc gccacaggtt ctcgagtgcg ttctggacga
    23521 gtacctcgct ctcgctgtcc agcgcgctcg tcgcctcgtc cagaatgagg atgggtttgt
    23581 cgtccaggaa ggcgcgggca atggcgatcc gctgccgttg cccggtcgag agtttgatgc
    23641 cacgttcccc gacgacggtg tcgtaaccgt cgggcgcccg cgagatgaag ctgtgcgcgt
    23701 gggcccgcag cgccgccgcc tccacctgcg cctgggtcac cgggcccgcg gtcccgtaga
    23761 cgatgttgtc ccggatggac cggtggaaga gggtggtgtc ctgcggaacg taggagatac
    23821 cccgagcgag ctggcggttg gacaccggaa caccgtccac ggcgaccatg cccggtggga
    23881 gcgggtagta gcctagcaac agcttgatga acgtcgtctt gccgcttccg ctgcgaccca
    23941 cgatgccgat cttttcgccc cgctcgatgg ccaggtcgat gcccgcgagc acgaggttcc
    24001 ggtcgttctc gggataggcg aacgacaggc cctggaactg cagccgaccg gaaaccgcgg
    24061 gaagaaccgc aggacggcct gaaccagctg aaccggctga attatccgga ctggccgaat
    24121 tatccggacc ggctgacagg atgttccgac cggcgaagag gtagtggtag gcctcctcga
    24181 tgcgggcgag tcggagattg agctgcgcaa tctcccacac cgtcccccag ataaagtcgg
    24241 agaagaggac cagcgcggag agaaaggtcg tgaactgggc caggctcatc tcaccgtgga
    24301 ggaatagata caggttgagg acgatcgaca ccggccagac gaggtaccgg accacgaggc
    24361 tcatcgaggt ccagaacaca atgctccaga aggacgagcg atacgcggcg gcgatgacct
    24421 ggcgacgacg ccggcggacc cgctcgtact cggcctcctc ctggaggaac gacttcacgc
    24481 tcacgaagtt cgagatgacg tcgatcacgt aaccgtccat ctccgagacc tcgtccgcga
    24541 gccgcttctc cgcgcgggcc gaacgacgga cggtgtgcct gccaacaaga agcatgatcg
    24601 cgacggaacc caggaaggtc aggcccgagt aaaggttaac cgaaaacatg atcattagga
    24661 tcgccggaac cttgaccagc tgttcaacgt acgtgaagca cgccgtctcg aggatctctc
    24721 ggaactcgcg gccgagcgtg ctcacatagc tgctgatctt tccggtgaac ttgccgacga
    24781 agtatggata tcgctcgttt atgacatttc caaagagaat gttctcgtat tcgtagcccc
    24841 ggtggttgag tagccggaga tacagcacct cggcaccacg ccaggtcagg tcatggccga
    24901 tgttgcacgc gagaaggacg ccggcgtaca ggtacgcgtc gtgggtctgt accggggcgc
    24961 tggcgagagc ctgcacgaga aggccgatga ggaccggtat cacggcgagc aggctgttgg
    25021 acaggacgaa gacaccgacg accaggagag ccggcccctt gaaggtcgcg acgaaacgca
    25081 gataggaacg cagggcggca tgccgctcca cccggcggga aacgaggttg tccacggcgg
    25141 tgccgacatc gtccaggccg gtgccgtttt gaccggcgcc acgggaaccg atgccaggcg
    25201 accgtatctc ctgatgcgga accccgccgg ccacgctgtc catgccgaga tgatgacagg
    25261 cgaccggccg ggcccgcacc ttgtttttga ccaggggaac ggccgcgtcc gcaccgaagc
    25321 tcacgagggc ctggccgtca catgcgccgg cccgatgtac tgtgctctgg cacgagacgt
    25381 gtcggacgcg cagaacgtcc gatccagtgg tgcgccgcta ccgaggtgta accgacagga
    25441 gaaatgctga cggtggcccg gtgcgtggcc gtcggatatc ccgagggaaa gggacgtcga
    25501 gtggctcgcc gccgttactt ccacctgctg agcgcgcttg ccatcgccgg actggcggtc
    25561 gcctgttccg gcgctggtgg cacggagtcc ggcgcgggac gctccccggc gctcgcgcgg
    25621 gagctggcgg aggccgcggt cgccgccccg gacgcctctc gcctcccgat cctgttcgtg
    25681 cacggcagcc ttgggtcggg cagcctcttc gagacaccgg cgcaacgatt caccgcaaac
    25741 ggctatcccg tcgactacgt cgaggccttc gactacgatg cgtcgtc
//
