LOCUS       NC_007777              20665 bp    DNA     circular CON 05-SEP-2024
DEFINITION  Frankia casuarinae, complete sequence.
ACCESSION   NC_007777
VERSION     NC_007777.1
KEYWORDS    RefSeq.
SOURCE      Frankia casuarinae
  ORGANISM  Frankia casuarinae
            Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
            Frankia.
REFERENCE   1  (bases 1 to 5433628)
  AUTHORS   Normand,P., Lapierre,P., Tisa,L.S., Gogarten,J.P., Alloisio,N.,
            Bagnarol,E., Bassi,C.A., Berry,A.M., Bickhart,D.M., Choisne,N.,
            Couloux,A., Cournoyer,B., Cruveiller,S., Daubin,V., Demange,N.,
            Francino,M.P., Goltsman,E., Huang,Y., Kopp,O.R., Labarre,L.,
            Lapidus,A., Lavire,C., Marechal,J., Martinez,M., Mastronunzio,J.E.,
            Mullin,B.C., Niemann,J., Pujic,P., Rawnsley,T., Rouy,Z.,
            Schenowitz,C., Sellstedt,A., Tavares,F., Tomkins,J.P., Vallenet,D.,
            Valverde,C., Wall,L.G., Wang,Y., Medigue,C. and Benson,D.R.
  TITLE     Genome characteristics of facultatively symbiotic Frankia sp.
            strains reflect host range and host plant biogeography
  JOURNAL   Genome Res 17 (1), 7-15 (2007)
   PUBMED   17151343
REFERENCE   2  (bases 1 to 5433628)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,J.C.,
            Glavina,T., Hammon,N., Israni,S., Pitluck,S., Goltsman,E.,
            Martinez,M., Schmutz,J., Larimer,F., Land,M., Kyrpides,N.,
            Lykidis,A., Francino,P., Benson,D.R., Huang,Y., Mastronunzio,J.,
            Bickhart,D., Niemann,J., Rawnsley,T., Tisa,L.S. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2006) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000013345.1-RS_2024_09_05
            Annotation Date                   :: 09/05/2024 02:41:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,755
            CDSs (total)                      :: 4,702
            Genes (coding)                    :: 4,516
            CDSs (with protein)               :: 4,516
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 53 of 186
            Pseudo Genes (incomplete)         :: 162 of 186
            Pseudo Genes (internal stop)      :: 10 of 186
            Pseudo Genes (multiple problems)  :: 37 of 186
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:46:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3627553
            Orig. end                         :: 3648218
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000249.1.
            URL -- http://www.jgi.doe.gov
            Source DNA and bacteria available from Louis Tisa
            (lst@patia.unh.edu)
            Contact: Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-PGF
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20665
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="19"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20665
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20665
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[<10000:10665](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<10001..10665)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(16..1527)
                     /locus_tag="FRANCCI3_RS15375"
                     /old_locus_tag="Francci3_3059"
     CDS             complement(16..1527)
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437444.1"
                     /locus_tag="FRANCCI3_RS15375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3059"
                     /product="bifunctional phosphatase PAP2/diacylglycerol
                     kinase family protein"
                     /protein_id="WP_023841278.1"
                     /transl_table=11
                     /translation="MRRDIALGRTFLHAFTSADRSLFAALAGGRPLLDPALPRLSHAAD
                     HGLLWWGVAGALGATKGRRRPAAVRGLLALGVASVLANGPMKVVFRRDRPPTHTIPPLR
                     RLREDLTTFSFPSGHAASAAAFATGVALDAPGAAVPVAVLAAAVAFSRVYVGVHYPGDV
                     AAGVLLGIGAGLATTKVMPRRPWAPARASPASAWAPALPDGDGLTVVVNARSGPGNHTD
                     LLAVLRADLPRARVVEVDAGGDVRTVLRSAAARSRVLGVAGGDGTINAAAQTALAHGVP
                     LAVFPAGTLNHFAADVGLAGAGDSVQAIREGSAVAVDIGRAEGIGATFSRFSRIFVNTA
                     SLGGYPDMVAIRARFERRIGKWPAMLIALSWVLRHETPFEVEIDSEYRRVWLIFVGNGI
                     YQPDGFAPTYRTRLDEGLLDLRVVDAAASLARLRLVGAVLTGRLGRSRVYEQHTVERVT
                     ISSRQPGPLPFACDGEVTEGVERIVITPGGARLIVYRPRRPGASG"
     misc_feature    1656..1671
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     gene            complement(1744..2130)
                     /locus_tag="FRANCCI3_RS28580"
                     /old_locus_tag="Francci3_3060"
     CDS             complement(1744..2130)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039316.4"
                     /locus_tag="FRANCCI3_RS28580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3060"
                     /product="DUF5999 family protein"
                     /protein_id="WP_011437445.1"
                     /transl_table=11
                     /translation="MLVQAVRVSDPASASPVPTDDPEPSSPEPSSVPLPADASRTAALR
                     RRGCPHCPPCPTADSADRDAARVASQHWDQGWILLCNGVILFEDTGEILPTGRTVEPRR
                     ALPRPGGVARPPAPRWASQAPVAF"
     misc_feature    2148..2163
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
     misc_feature    complement(2350..2364)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     misc_feature    complement(2452..2466)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            2534..3976
                     /locus_tag="FRANCCI3_RS15385"
                     /old_locus_tag="Francci3_3061"
     CDS             2534..3976
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437446.1"
                     /locus_tag="FRANCCI3_RS15385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3061"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_011437446.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 9.7e-23,
                     bitscore: 79.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGATGVGTGTDAFGGIPTGGGFGPRAGGQPVEVSVVMPCLNEQE
                     SVGVCVRKALAGLATAGAAGEVVVVDNGSTDRSADVAAAAGARVVRETRRGYGNAYLAG
                     FAAARGRLIVMGDADDSYDFSDLGVLLAPLRAGRADYVLGSRFAGEILPGAMPWLHRYV
                     GNPVLTGILNRLFDVRSSDAHSGMRAFSREAYLRMQLRCEGMELASELVIAAGRAELRI
                     EEVPITYHPRVGASKLHSLRDGWRHLRFMLLLAPRHLFVLPGLVLLALGIVGQAALLPG
                     SLNLGFHRLDLHFSILFALLALLGWQLVLLGVCADVHNHALGWQERRRWPLPLIHRLFT
                     LERGLALGAGLFIVGFVVDVVVLVRWLVNNLGPLNEMRPALLAMTLMVLGAQTAFGSFF
                     LRLLTAGPSGGHQRASARGTRAGTGTGTGTGTGTGTGTGTGTGTGTGTGSTQAEASGPR
                     ADTPGLGLCFEAPEHPAEVVRF"
     gene            3995..5764
                     /locus_tag="FRANCCI3_RS15390"
                     /old_locus_tag="Francci3_3062"
     CDS             3995..5764
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437447.1"
                     /locus_tag="FRANCCI3_RS15390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3062"
                     /product="hypothetical protein"
                     /protein_id="WP_011437447.1"
                     /transl_table=11
                     /translation="MAVLGRMVVSGRRRFPPLPGDAAPVSLCDPAVFGDDPASGNDPAD
                     DLAAPGRVPSGEHPGPLYGPNARRRESGPASAQPARPAQPARPARPVARHLPFAVLLVA
                     GMTLRVVTGYAYRPAFEFSGDSYAYLRLSTLHAPDPMRPAGYPAFLRLLSHTGDLWWVT
                     VVQHVAGLALGVGIYVLLVHRRVAAPVAALAAAPVLLDAYQLVLEHYVMAETLFAVLLV
                     AAMIALTWSARPSVWACGLAGLLLGGAGLVRTIGVAMGVLAVGYLLLRRVGWLRPAAFA
                     VMLAVPLVGYAGWFHHAHGKYALTGGDAVWMYGRVAPIAECDRLHLSTRQLVLCSPHPV
                     AGRPDPSYYVWNGNSPHWRLDMPDDKRDALLRDFTRQVIRYQFGDYARMVGGEIAHYFA
                     PGRPVGHRDWPDATWRFPTGNEPRYLHNGEPLLGFHGDAPSRVIREPSAGFLRSYQHLV
                     FTPGPALAGMVILAVVAIMIPGRDRRAPPGNRGSRRRRGLRDRAAEDRRLRADMALLVA
                     AGAATLIVPAATVCFDYRYLLPVLVLFPPAAALATRRFVLLNRSRRAPAEEPGINGSSR
                     APAGVPPSPGRCP"
     misc_feature    4727..4729
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5706..6146)
                     /locus_tag="FRANCCI3_RS15395"
                     /old_locus_tag="Francci3_3063"
     CDS             complement(5706..6146)
                     /GO_function="GO:0120225 - coenzyme A binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437448.1"
                     /locus_tag="FRANCCI3_RS15395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3063"
                     /product="CoA-binding protein"
                     /protein_id="WP_235462795.1"
                     /transl_table=11
                     /translation="MGGYAGMRFGDDDTIRRMLTDTEVWAVVGLSNDTRRTAYSIADYL
                     RRHGKHVVPVHPSAPVVAGEQGYATLSEIPFPVDVVDLFVRSELAGPLVDEAVKIGAKG
                     VWLQLGVRDEAAAARAGEAGLDVVMDTCPAMEAPRLGLGWSR"
     gene            6329..6646
                     /locus_tag="FRANCCI3_RS15400"
                     /old_locus_tag="Francci3_3064"
     CDS             6329..6646
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]"
                     /GO_function="GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]"
                     /GO_process="GO:0051290 - protein heterotetramerization
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009742947.1"
                     /locus_tag="FRANCCI3_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3064"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_011437449.1"
                     /transl_table=11
                     /translation="MSDKHEVTLSASAERDLSKLAELTRGEVRRFLDGALRDDPRKAGT
                     PIPGEQVGMHEASGRTWRILYRIDANTRSVRVMVVAPRGARSRIVPTIGNARPATGWRR
                     V"
     gene            complement(6674..7255)
                     /locus_tag="FRANCCI3_RS15405"
                     /old_locus_tag="Francci3_3065"
     CDS             complement(6674..7255)
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437450.1"
                     /locus_tag="FRANCCI3_RS15405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3065"
                     /product="TerD family protein"
                     /protein_id="WP_011437450.1"
                     /transl_table=11
                     /translation="MTSVSLSKGGNVSLSKVAPNLTAVTVGLGWQVRQTTGAAYDLDAS
                     AIIVNDAGQVLSDGYFVFFNNLVSPDGAVKHLGDNLVGGGGGDDEQINVDLRMLTPQAA
                     KVVFTVSIYDADSRRQAFGQIRNAFIRVTDATNGAEVARYDLTEDASTETAMIFGELYR
                     YGGEWKFRAVGQGYASGLRGIALDFGVNVS"
     gene            complement(7303..8394)
                     /locus_tag="FRANCCI3_RS15410"
                     /old_locus_tag="Francci3_3066"
     CDS             complement(7303..8394)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437451.1"
                     /locus_tag="FRANCCI3_RS15410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3066"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_011437451.1"
                     /transl_table=11
                     /translation="MGEVVDAALGDVGVPRQTGPQPAVERAGRDGAARWRRPLPPVEQV
                     RPGLWSIPVPLPWAKPAHVFVYVFETSTGPFLMDAGWDFDEAFDELQAGLAMIGMSVAD
                     VRGVVVTHAHLDHYGLANRIREASGAWVSLHRLDEAMLRHFEHGYADRISELMIRAGAP
                     AEMTERLLAGYQQPAPGLSRPDILLEDGDRPDIPGWDLTALWTPGHSPGHLCFWEPTNR
                     LLFSGDHVLPSTAVGVSAPEEAVPDPLGDYLRSLARLRSLPAEEVLPAHEYRFTGLERR
                     LAELDAHHAGRLSEVVEGLRAGASRVWDVAGYVTWHRPFRNLRGVALQNAVMDTMSYLA
                     TLEATGAARSEPGTPDRWRLIEP"
     gene            complement(8611..9678)
                     /locus_tag="FRANCCI3_RS15415"
                     /old_locus_tag="Francci3_3067"
     CDS             complement(8611..9678)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437452.1"
                     /locus_tag="FRANCCI3_RS15415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3067"
                     /product="hypothetical protein"
                     /protein_id="WP_148214916.1"
                     /transl_table=11
                     /translation="MAVLVVIVAGLVVVRGRMAGDHRAGSSGGRPGAPVAAPAPTPGDE
                     DGPADVTAAPVTARPGAGPALSTASAASPSTGIGSVSPRVAPTAARPRTGPPPGSPAVP
                     VAARPAGPALSLSSTRVDLGDVDSVWRLDLRGEGTAPVDVVIGASPSWLTVVPGRSRID
                     PGAVVPLVITLDRAAAPSGPIDVTVPVRPRKGDGGGDVRVTARVDGSPQVVSMVAAPTT
                     LYPSGCAPAARVTASPVTASPVTASPVTASPVTASPVTASPVTASPVTVSTVTVSVVDA
                     TGIFAAELVVNLPDGGRASVSLVLDRATGNRSTWSGPVGPARVAGAITYTATVTDLDGR
                     RSRAPGSLTVLPCPS"
     misc_feature    complement(9777..9797)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.11"
                     /tool="antismash"
     gene            complement(<10001..10288)
                     /locus_tag="FRANCCI3_RS29130"
                     /pseudo=""
     CDS             complement(<10001..10288)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006545316.1"
                     /locus_tag="FRANCCI3_RS29130"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lycopene cyclase domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 4.6e-19,
                     bitscore: 66.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYTALAVVGVALAIAMDLWVLRTRLLTRRVFWTSYAIIALFQLI
                     SNGILTGFGIVVYDPRRILGPRIAHAPVEDLLFGFALVTQTLAWWVWWGRR"
     gene            complement(10285..10665)
                     /locus_tag="FRANCCI3_RS15425"
                     /old_locus_tag="Francci3_3069"
     CDS             complement(10285..10665)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437454.1"
                     /locus_tag="FRANCCI3_RS15425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3069"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_011437454.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 4.6e-20,
                     bitscore: 70.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHLSYLAVLAGCLLGTAPLEVFLGTRVYARPVRLLLTLAPVIVI
                     FVVWDLFAVSAGHWSFDRRRITGILLPGGLPLEELLFFAVVPMCAILTLEAVRAVRGWD
                     VGDEPAHPSATRSDGTPDGDRP"
     gene            complement(10695..11408)
                     /locus_tag="FRANCCI3_RS15430"
                     /old_locus_tag="Francci3_3070"
     CDS             complement(10695..11408)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437455.1"
                     /locus_tag="FRANCCI3_RS15430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3070"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_011437455.1"
                     /transl_table=11
                     /translation="MLSPEVEGSSPRAGGPARADRLRRLADARLYLCTPRRAEFDAFLS
                     AVVGTPEAPGVDLIQLREKGLEWDEELGGLRRVQAAAGARGVLVSANDRADLAAFAGVD
                     ILHVGQGDIPPRFARRLVGPDVLIGQSTHDPDQFLAALADPDVDYVCVGPVHATPTKEG
                     RPPVGLGLPRLAARHAPPFAPGVKPWFVTGGVGPDTLDQILATGARRVVVVRGLTGVED
                     PAASAVALAQRLRAV"
     gene            complement(11389..11646)
                     /gene="thiS"
                     /locus_tag="FRANCCI3_RS15435"
                     /old_locus_tag="Francci3_3071"
     CDS             complement(11389..11646)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437456.1"
                     /locus_tag="FRANCCI3_RS15435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3071"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_011437456.1"
                     /transl_table=11
                     /translation="MVDRPPHLHPRAHPEPLARARVVVNGAPRGIPGGQPLPDLLAELG
                     LPSGSVVVEHNGVALTPSEIPAVRLADGDILEIVRAVAGG"
     misc_feature    11639..11654
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    11644..11653
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     gene            complement(11712..12035)
                     /locus_tag="FRANCCI3_RS15440"
                     /old_locus_tag="Francci3_3072"
     CDS             complement(11712..12035)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018501939.1"
                     /locus_tag="FRANCCI3_RS15440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3072"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_023841271.1"
                     /transl_table=11
                     /translation="MDWLTLPDVADQLQVPVTRVRQMVRDRTLLARREGGVLRVPADFI
                     RDGAVVKGLPGLLTVLADAGFTDEDALDWIFREDPSLPGTPMQALIENRGKEVKRRAQA
                     SAF"
     gene            complement(12163..13812)
                     /locus_tag="FRANCCI3_RS15445"
                     /old_locus_tag="Francci3_3073"
     CDS             complement(12163..13812)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437458.1"
                     /locus_tag="FRANCCI3_RS15445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3073"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_011437458.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.1e-15, bitscore:
                     56.4, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.9e-21,
                     bitscore: 74.4, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRIHLVSNLAGVNALGDHLRAAGLGPTSARSADALLVLIDRPLD
                     HVEQELLDRARQTVPVLLAGPTMRALPPGSPLIEASGFIPGRTTAPYDLRLTVGPQGGA
                     VMARSADFRPRESWIIPDKIADDVERLLLVRHEMGEHPVCTWRPSTGLGIFTLGTGPAV
                     LADPAYQRLVGRWLRHCLGVLDAAPARVGLLGTPDITGTHHSAVDATEGLELAALCDGG
                     AGRLPAHAAGRPPRRVDDPDDLVNDPDLGVVIVATPTHTRLEWAGRALEAGKHVVVHAP
                     LCLSTPDADQLAELAEARSLVLAVYPEGRDDPGYRAVRAAVHRGAVGEPLRLDAHRGGF
                     RRPAGTWHDDERISGGQLHDRGSACVDQILALVDEPVEWVSASTVKRVWHHVSNADHSR
                     LLLRFASGAEAQVTVSDLTVARRPRFEVLGSTGSLILDGAFRDGGAFRDGEGKLVPRLG
                     RHAGRRSEVEAEAEILEAEAGSLVLITHDGVRSHIPLAPTSGSTFHRDLADCLVSGWPL
                     SGYGVQTARPVVAVLEAAVRSAAAGGAQVAAL"
     misc_feature    complement(13860..13876)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.48"
                     /tool="antismash"
     misc_feature    13895..13910
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     misc_feature    complement(13943..13957)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.41"
                     /tool="antismash"
     gene            complement(14050..15285)
                     /locus_tag="FRANCCI3_RS15450"
                     /old_locus_tag="Francci3_3074"
     CDS             complement(14050..15285)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437459.1"
                     /locus_tag="FRANCCI3_RS15450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3074"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_011437459.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.1e-46, bitscore:
                     155.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRIVVVGAGMAGGRAAAEVRARGFAGEVILLGAEPHRPYDRPPL
                     SKAVLSGRIDDTTLPFDLDGVEVRLGRRATGLRPGTVETDAGPLDYDGLVLATGADPVT
                     LPGDGPQRVLRSIDDARDLRGALRPGVRLVIVGAGWIGAEVATAAAAIGAEVTVVEAAA
                     SPLFAALGAQVGRCTIAWYARAGVTLRLATAVERVTPDGLVLAGGEELIADEVVVGVGV
                     RPGTAWLAGSGLALDRGVVVDEHLAARWTHGADGADGDRPPVVAVGDCAAWWSRRYGRR
                     LRVEHWDCAQQSPAVAVSTLLGGEAVYDPVPYFWSEQFGRMVQFAGLPSAEAAPVFRGD
                     PGVVVPPDGGRPSGWSAGWFAPDGRLEALVTVGRPMDMVAGRRLMAADGIPDRERFADI
                     SVSMKELAAASR"
     misc_feature    complement(15286..15301)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.87"
                     /tool="antismash"
     gene            complement(15325..16491)
                     /gene="thiH"
                     /locus_tag="FRANCCI3_RS15455"
                     /old_locus_tag="Francci3_3075"
     CDS             complement(15325..16491)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF06968"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437460.1"
                     /locus_tag="FRANCCI3_RS15455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3075"
                     /product="2-iminoacetate synthase ThiH"
                     /protein_id="WP_011437460.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-10, bitscore: 40.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="PF06968 (E-value: 6.3e-20, bitscore: 69.2,
                     seeds: 824, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPPGEFARELAGHDLAGLSAMSRRATSAEVDTVLRRVRPGSGG
                     SATPRIGLAELAILLSPAATARLEELAIAAREATLLRFGRAVRLFAPMYVSNACLSSCT
                     YCGFAKGLPVVRRTLDLEEVVAEGRLLVDRGFRHLLLVSGEHRVEVSADYLVAVVERLR
                     PMFPSISIETQTWSDDTYARLVRAGLEGVVHYQETYDRARYAEVHVAGWKRDYDRRLSS
                     FERAARAGVRRLGIGALLGLAPDWRADVLALAAHASFLSRRYWRTEVSIALPRIKPSAS
                     GFPPVVVVDDAEFVQAYAALRLFEPDLALSLSTREPAVLRDGLVRIAVTTMSAGSSTEP
                     GGYTTPGTAQEQFSISDERSPAQIAAMLAEAGYEPVWKDAFPLVDPVR"
     gene            complement(16488..17501)
                     /locus_tag="FRANCCI3_RS15460"
                     /old_locus_tag="Francci3_3076"
     CDS             complement(16488..17501)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437461.1"
                     /locus_tag="FRANCCI3_RS15460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3076"
                     /product="thiazole synthase"
                     /protein_id="WP_011437461.1"
                     /transl_table=11
                     /translation="MSQHPLRPAGSRPGDSPPDGSCPDGLAGGGSAVGGGGGGEAGPGA
                     AGADDLVIAGRAYGSRLLIGTGKFASHRVMRDSLVASGATIVTVALRRVDIGRIGDGDV
                     LDFIPPSMTLLPNTSGAVDAAEALRLARLGRAATGTGLVKLEVTPDPRTLAPDPLETLR
                     AAELMVADGFTVLPYCSADPVLARRLEEVGCATVMPLGSWIGSNRGLRTRDAIEAIVAS
                     AGVPVVVDAGLGVPSDAAEAMEIGAAAVLVNTAIAVAADPARMARAFALATAAGRLGFL
                     AGRGAAGPATVASASSPLTGFLGAHPSPASHPSPASPVPSVSRATSPAAVVGEASR"
     regulatory      complement(17497..17610)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            17880..19994
                     /gene="pknB"
                     /locus_tag="FRANCCI3_RS15465"
                     /old_locus_tag="Francci3_3077"
     CDS             17880..19994
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011437462.1"
                     /locus_tag="FRANCCI3_RS15465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_3077"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_236701474.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-45, bitscore:
                     154.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADPVVGRLLDGRYTAQERLAVGGMATVYVAHDNRLDRLVALKVM
                     HPTLNHDPEFVTRFHREAKAVARLNTPRVVSILDQGSDHIPAGLVNYLVMELVRGRSLR
                     QHLGARGRLPVTEAIEIIEPVIEALAAAHAAGIIHRDIKPENILLGDDGQVKVADFGLA
                     RPVSQPTQALTGGVVMGTVGYLAPEQVTHGVADTRSDVYAAGVVLFESLTGQLPHSGAT
                     PMSVAYQSVHGDVPAPSTMIEGIPAELDGLVLRATARDPARRPVDGAALLAELRRIEPF
                     LPPQDAYPSGFTGEIERIGLAERPSGAREPGYPQEPGYTQPFQAEDYDDSRGAGPGAAA
                     ERAFAGAGPGQPGTGALYRSASPPSPTATAYLGGGGGRGRRRAAASPRSRGLIPVVVGG
                     MAVLVLLLGILAFRSLSGGGTEVPLLTNLSRSDAEKMLRDAGFQFTYLDPVASATVPVG
                     HVAQQDPRDGSKVDKGALITLRLSSGPATVRVPDLANLTETQAKARLAEVDLTLGGLSP
                     QSSDTVPAGHVIGTNPGAGTALKPKDQVVVITSTGPATKPVPADIIGKSFEEAKAELVG
                     LNIGLVVQRTDAVNDAVQPGEVFGVSPDVGQPISPGGTVTLTVAEADGFDNGDGSGGDG
                     SGIQVPVPNVVGKSYREAENILQRRGLKIDRIGWIGGPGDRVTSQSAKAGSKIEKGSTV
                     HVNTTWDPLG"
     misc_feature    complement(17881..17895)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(20017..20033)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.36"
                     /tool="antismash"
ORIGIN
        1 gtccaccggc ccggctcagc cggatgcgcc gggccgccgc ggccggtaga cgatcagtcg
       61 ggctccgccc ggagtgatga cgatgcgttc cactccctcc gtgacctcgc cgtcacaggc
      121 gaacggcagc gggccgggct gacgggatga gatcgtgacc cgttcgaccg tgtgttgttc
      181 gtacacccgg ctgcgcccga gacggccggt cagcaccgcc cccaccagcc ggagccgggc
      241 aagcgacgcc gcggcgtcga ccacccgcag gtccagcagc ccttcgtcga ggcgggtgcg
      301 gtaggtgggg gcgaacccgt cgggctggta gatcccgttg ccgacgaaga tcagccagac
      361 ccggcggtac tcggagtcga tctcgacctc gaacggcgtt tcgtggcgca gcacccagct
      421 cagcgcgatg agcatcgccg gccacttgcc gatgcggcgc tcgaaccgcg cacggatggc
      481 gaccatgtcc gggtaaccgc cgaggctcgc ggtgttcacg aagatgcggg agaaccgact
      541 gaacgtcgcg ccgatgccct cggcccggcc gatgtcgacg gcgaccgccg aaccctcccg
      601 tatcgcctgc accgagtcac ccgccccggc gagtccgacg tccgcggcga agtggttgag
      661 cgtgcccgcg gggaagaccg ccagcggcac gccgtgcgcc agcgcggtct gggcggccgc
      721 gttgatggtg ccgtcgccgc cggcgacgcc cagcacacgg gaccgcgccg ccgcggacct
      781 cagcacggtt cttacgtcgc cgcccgcgtc gacctcgacg acccgggccc tgggcaggtc
      841 ggcccgcagc acggcgagca ggtccgtgtg gttacccgga ccggaacggg cgttcaccac
      901 cacggtaagg ccgtcgccgt cgggcagggc gggcgcccac gccgacgcgg ggctggcccg
      961 ggcgggggcc cacggccgac gcggcatcac cttcgtcgtc gccaggcccg cccctatccc
     1021 cagcagcacg ccggcggcca cgtccccggg atagtgcacc ccgacgtaca cccgggagaa
     1081 cgccaccgcg gcggcgagca cagccaccgg caccgccgcg ccgggtgcgt ccaacgcgac
     1141 tccggtggcg aaggcggctg ccgacgccgc gtgcccagag gggaacgaga acgtcgtgag
     1201 atcctcgcga agccgccgca gcgggggaat cgtgtgagtc ggtgggcggt cccggcggaa
     1261 caccaccttc atcggcccgt tggcgagaac gctcgcgact cccagggcga gcaggccacg
     1321 gacggccgcc gggcgacggc gtcccttcgt cgcaccgagc gccccggcca ccccccacca
     1381 gagcagacca tgatcggcag cgtgggacag ccgcggcagc gccgggtcga gcagcggtct
     1441 gccgccggcc agcgccgcga acagcgaccg gtccgcactg gtgaaggcgt gcaggaacgt
     1501 ccggcccagc gcgatgtcac ggcgcatgag gatccggacg cgccgaccga cccggttctc
     1561 cgcgggccag cggggagcgg tcccgtttcc cggcctcgtc accgaccttg acgccacgcc
     1621 ggcaccgtac ccgtaagggg gacacccaga tcaactggga tgaacttcac atcctcccga
     1681 actccacgga aggagcgagc agaaggagct cgctgtcagg ccgcgcctgt cagaacgcga
     1741 ccgtcagaac gcgaccgggg cctggctcgc ccatctcgga gccggcggcc gtgccacgcc
     1801 cccgggccgg ggcagcgccc gtcgtggctc gacggtgcga cctgtcggca ggatctcgcc
     1861 ggtgtcctcg aacagaatca ccccgttaca cagcaggatc cagccctggt cccaatgctg
     1921 gctggccacc cgggcagcgt cgcgatccgc actgtccgcc gtggggcagg gcggacagtg
     1981 cgggcaacca cgtcgccgga gcgcggctgt gcgtgaggcg tcagcgggca ggggaactga
     2041 ggacggctcg ggcgaggagg gctccgggtc gtcggtgggc accggggacg ccgatgccgg
     2101 gtctgaaacg cgaacagctt gcacgagcac cagacgttac gcctctccgt aagaagcgtc
     2161 acaccgaggc gcgtgtgaag gggccgacgt gtctgcgacc cttgactcgc aagtcagcgt
     2221 gggcaacggc cgtgaccagc gcggatgcga aacgcggcac atcgggaacc agccggacgg
     2281 accacggggt gtctacagcg agataccggt aacaggaccg gaccatcgga tcggtaggtt
     2341 acggggcggt ggccgagcgg ttccgccatc ctgaccgcaa caatgacgtg ggccggttcc
     2401 gctgatgcgc ccacctgcat gaacggcgcc cgttgtcccc ggcgaccggg catcgacacg
     2461 gcagagccac ggacaggcac cggtgaacgg ccacggaccc ggacatgccc ggccacaagg
     2521 gggggtacgg acgatggacg gtgccacggg tgtcggtacc ggtaccgacg ccttcggggg
     2581 catccccacc ggcgggggtt tcggcccgcg tgccggcgga cagccggtcg aggtgtcggt
     2641 cgtcatgccg tgtctgaacg agcaggagtc ggtcggcgtc tgtgtgcgca aggcccttgc
     2701 gggactggcc accgcgggtg ccgcgggcga ggtcgtcgtt gtcgacaacg gatccacgga
     2761 ccggtcggcg gacgtcgccg cagccgcagg tgcccgggtc gtccgcgaga cccggcgcgg
     2821 ctacggcaac gcctacctgg ccgggttcgc cgccgcccga ggccggctga tcgtgatggg
     2881 cgacgccgac gactcctacg acttctcgga tctgggcgtc ctgctcgctc cgctgcgcgc
     2941 cgggcgggcc gactacgtgc tcgggtcgcg cttcgctgga gagatcctgc cgggagcgat
     3001 gccctggctg caccgttacg tcggcaaccc tgtgctcacc ggcatcctga accggctgtt
     3061 cgacgtccgt tcctccgacg cgcactcggg catgcgggcc ttcagccgag aggcgtacct
     3121 gcgtatgcag ctgcgctgcg aggggatgga gctcgcctcc gaactggtga tcgccgcggg
     3181 ccgcgccgag cttcggatcg aggaggtgcc gatcacttac catccgcggg tcggggcctc
     3241 caagctgcac tccctgcggg atggttggcg gcacctgcgg ttcatgctgc tgctggcgcc
     3301 gaggcacctg ttcgtgctgc ccggcctggt gctgctggcg ctcgggatcg tgggccaggc
     3361 ggcgctgctg cccggctcgc tcaatctcgg cttccaccgg ctggacctgc acttctcgat
     3421 cctgttcgcg ctgctggcgc tactcggctg gcaactggtg ctgctggggg tctgcgccga
     3481 cgtccacaac cacgccctcg gctggcagga gcgccgccgc tggccgctgc cgctcatcca
     3541 ccgcctgttc accctcgaac gcgggcttgc gctcggcgcg ggcctgttca tcgtcggatt
     3601 tgtcgtggac gtggtcgtcc tcgtccgctg gctggtcaac aatctcggac cgctcaacga
     3661 gatgcgcccg gccctgctcg cgatgacgct gatggtgttg ggcgcgcaga ccgccttcgg
     3721 atccttcttc ctgcggctgc tgaccgccgg acccagcggg gggcatcagc gggcgtcggc
     3781 ccgcggtacc cgtgccggca cgggtaccgg cacgggtacc ggcacgggta ccggcacggg
     3841 taccggcacg ggtaccggca cgggtaccgg cacgggctcc acccaggccg aggcgagcgg
     3901 tccacgggcc gacacgcccg gcctcggcct gtgcttcgag gcgccggaac acccggccga
     3961 ggtcgtcagg ttctgagaac ggcggatatt catcatggcc gtcctgggca gaatggtcgt
     4021 ctcgggcaga cgccgctttc caccgctgcc cggtgacgcc gcgcccgtct ccctatgcga
     4081 tcccgctgtc ttcggggatg accccgcctc cgggaatgac cccgcggatg acctcgccgc
     4141 cccgggccgg gtgccgtccg gggagcaccc cggcccgctc tacggcccga acgcgcggcg
     4201 ccgtgaatcg ggtccggcct ccgcccagcc ggcccgaccc gcccagccgg cccgacccgc
     4261 ccggccggtc gcgcggcatc tgcccttcgc ggttctcctg gtcgccggga tgaccctgcg
     4321 ggtggtcacc gggtacgcct accggccggc gttcgagttc agcggagact cctacgccta
     4381 cctgcgactt tccaccctgc acgcgcccga cccgatgcgg ccggccggat acccggcctt
     4441 cctgcgcctg ctgtcgcaca ccggcgacct gtggtgggtg acggtggtcc agcacgtcgc
     4501 gggcctggcg ctcggggtgg ggatctacgt cctgctggtc caccgccgag tggcggcccc
     4561 ggtggcggcc ctcgccgccg cgccggtcct gctggacgcc taccagctgg tcctcgagca
     4621 ctacgtgatg gccgagaccc tgttcgcggt cctgctggtc gccgcgatga tcgccctgac
     4681 ctggtcggca cgaccgtcgg tgtgggcgtg cgggctcgcc ggcctgttac tgggcggggc
     4741 gggcctggtc cgcaccatcg gggtcgccat gggtgtgctc gccgtgggct acctgcttct
     4801 tcgtcgcgtc ggatggctcc ggcccgccgc cttcgccgtg atgctcgccg ttccactcgt
     4861 cggatacgcg ggctggttcc accacgcgca cgggaagtac gcgctcaccg gtggggacgc
     4921 ggtgtggatg tacggccggg tggcaccgat cgccgaatgt gatcgcctac acctgagcac
     4981 gcgccagctc gtcctgtgct ccccgcatcc ggtggcgggg cggcccgatc ccagctacta
     5041 cgtctggaac ggcaacagcc cgcactggcg gctcgacatg cccgacgaca agcgggacgc
     5101 gctgctgcgc gacttcaccc gccaggtcat ccggtatcag ttcggtgact acgcccggat
     5161 ggtcggcggg gagatcgcgc actacttcgc cccgggccga ccggtcgggc accgtgactg
     5221 gccggacgcg acctggcggt tcccgaccgg taacgaaccg cgctacctac acaacggcga
     5281 gccactgctc ggcttccacg gggacgcgcc cagccgcgtc atccgcgagc cgtccgccgg
     5341 tttcctgcgg agctaccagc atctcgtctt cacgcccggt ccggccctgg ccgggatggt
     5401 gatccttgcc gtcgtcgcga tcatgatccc gggacgggac cgccgtgcgc cgccggggaa
     5461 ccgtggctcc cggcgccgga gaggcctgcg ggaccgggcc gccgaagatc gacggctgcg
     5521 ggcggacatg gccctcctcg tggcggccgg ggccgccacg ctcatcgtcc cggccgcgac
     5581 ggtgtgcttc gactaccgct acctgctccc cgtcctcgtg ctcttcccgc ctgccgccgc
     5641 gctcgcgacc cgccggttcg tgctgctcaa tcgatcgcgc cgggcgcccg cggaggagcc
     5701 ggggatcaac ggctccagcc gagccccagc cggggtgcct ccatcgccgg gcaggtgtcc
     5761 atgacgacgt ccagcccggc ctcgcccgca cgcgccgcgg cagcctcgtc ccgcacaccg
     5821 agctggagcc agaccccctt cgcgccgatc ttcaccgcct cgtcgacgag cgggccggcc
     5881 agctccgacc ggacaaacag gtcgacgacg tcgacgggaa acgggatctc gctcaacgtc
     5941 gcgtatccct gctcccccgc gaccacgggt gccgaaggat gcaccggcac gacgtgcttg
     6001 ccgtgccgtc gcaggtagtc cgcaatgctg taggcggtcc ggcgggtgtc gttggacagc
     6061 cccaccaccg cccagacctc ggtgtcggtg agcatgcggc gaatggtgtc gtcatctccg
     6121 aagcgcatac ccgcataacc gcccatgccg cccggttcat ccggaccgcg gaaggacttc
     6181 tcagttcccg gcaacgattc ccggcaacgg gggcgagaag cacgagcccc ggtggaggcg
     6241 ggcgcatagg atcttcacgt ggagaacgtg gagctttccc cgcttccggc cgccggggga
     6301 cggctggccg ccggggctgg agccggcggt gagtgacaag cacgaggtga cgctgtccgc
     6361 ctcggccgag cgggacctgt cgaagctggc cgagctcacc cgcggcgagg tccgtcggtt
     6421 cctcgacggt gccctgcgcg acgatccgcg caaggccggc actccgatcc ccggcgagca
     6481 ggtcggcatg cacgaggcca gcgggcggac ctggcggatc ctctaccgga tcgacgccaa
     6541 cacacgctct gtgcgcgtta tggtcgtcgc gccgcgaggt gcccgctccc ggatcgtgcc
     6601 aacgatcggc aacgcccgcc ccgcaaccgg atggcgccgg gtctgagccc gggcggtcac
     6661 gaggcccggg cggtcaggag acgttgacgc cgaagtccaa ggcgatcccg cgcaacccgg
     6721 aggcgtatcc ctgaccgaca gcgcggaact tccattcccc accgtagcgg tacagctcac
     6781 cgaagatcat cgccgtctcc gtggaggcgt cctcggtgag gtcgtagcgg gccacctccg
     6841 cgccgttcgt cgcgtccgtc acccggatga acgcgttgcg gatctggccg aaggcctgcc
     6901 gacgcgagtc ggcatcgtag atggacacgg tgaacacgac cttcgccgcc tgcggggtca
     6961 gcatccgcag gtcgacgttg atctgctcgt cgtcaccgcc gccgccaccg accaggttgt
     7021 cacccaggtg cttcaccgca ccgtccggac tcaccagatt gttgaagaac acgaaatagc
     7081 cgtcggagag gacctggccg gcgtcattca caatgatcgc gctggcgtcg agatcgtagg
     7141 cggcaccggt ggtctgccgc acctgccacc ccaggcccac cgtcacggca gtgaggttgg
     7201 gggcgacctt actcagcgag acattgccgc ccttggacag cgacacggag gtcatatcct
     7261 caccttagta cgaatggtcc ccgccctgcc gaccggcggg ccctacggct cgatcaggcg
     7321 ccaccggtct ggtgttcccg gctcggaacg cgccgcgccg gttgcctcca gcgtcgcgag
     7381 gtacgacatc gtgtccatca cggcgttctg cagcgccacc ccccgcaggt tgcggaacgg
     7441 ccgatgccag gtcacgtatc cggcgacgtc ccagacccgc gaggcacccg cgcgcagtcc
     7501 ctcgacgacc tcggacagcc ggccggcgtg atgcgcgtcg agctccgcga gccggcgctc
     7561 cagcccggtg aaccggtact cgtgcgccgg cagcacctcc tcggccggca ggctccgcag
     7621 ccgggccagc gaacgcaggt agtcccccag cggatcagga acggcctcct ccggcgcgga
     7681 taccccgacc gccgtcgagg gcaggacgtg gtccccggag aacagcagcc ggttggtcgg
     7741 ctcccagaag cagaggtgtc ccggcgaatg gcccggtgtc cacagcgcgg tgagatccca
     7801 gcccgggatg tccggccggt cgccgtcttc gaggaggatg tcgggtcgcg ataggcccgg
     7861 ggccggctgc tggtagcccg ccagcagccg ctcggtcatc tcggcgggcg ccccggcccg
     7921 gatcatcagc tcggagatcc ggtcggcgta accatgttcg aagtgccgga gcatcgcctc
     7981 gtccaggcga tgcaacgaga cccacgcccc ggatgcctcc cggatccggt tcgccaggcc
     8041 gtagtggtcc aggtgcgcat gggtcaccac gacgccccgc acgtcggcca ccgacatccc
     8101 gatcatcgcc agtccggcct gcagctcgtc gaacgcctcg tcgaagtccc agcccgcgtc
     8161 catcaggaac gggcccgtgg aggtctcgaa aacgtacacg aacacgtgcg ccggtttggc
     8221 ccagggcaac gggacgggaa tactccacag tcccggacgc acctgctcga ccggtggcag
     8281 gggccgacgc caccgcgcgg caccgtcccg gccggcccgc tccacggccg gctgcggccc
     8341 ggtctgacgc ggcacaccga catccccgag agcagcgtcc acgacctcac ccacccgttt
     8401 tctccggcgc ccgacggcgc gtgcatcgcg taccgcggcg ccccgggcct gcggcacccg
     8461 tctctgggcc tgcgccaccc gacggaacct tggcgcgtcc cggccaacct gtcatgctat
     8521 accgcgccgc ccggtacccc ccgaaccggg cggcgccata ctttcccacc gccgtcaccg
     8581 ccgtcaccgc cgtcaccgtc accgcgccgg tcaggagggg cagggcagaa cggtgaggga
     8641 tcccggtgcc cgggagcgcc gcccgtcgag atcggtcacc gtggccgtgt aggtgatcgc
     8701 cccggccaca cgggccgggc ccaccgggcc ggaccacgtc gaccggttac ccgtcgcccg
     8761 gtcaaggacc agcgacacac tagccctgcc tccgtcgggg aggttcacca cgagctccgc
     8821 ggcgaagatg ccggtcgcgt ccacgacgga caccgtcacc gtggacaccg tcaccgggga
     8881 cgcggtcacc ggggacgcgg tcaccgggga cgcggtcacc ggggacgcgg tcaccgggga
     8941 cgcggtcacc ggggacgcgg tcaccgggga cgcggtcacc ctcgcggccg gcgcgcagcc
     9001 ggacgggtac agcgtcgtcg gcgccgcgac catcgacacc acctgtggcg agccgtcgac
     9061 cctggcggtg acccgcacgt cgcccccgcc atcacccttg cggggcctga ctggaacggt
     9121 cacatcgatc ggtccggacg gtgccgccgc ccgatcaaga gtgatcacca gggggacgac
     9181 ggcccccgga tcgatccgcg accggccggg caccacggtt agccaggacg ggctggcgcc
     9241 gatcacgacg tcgaccggcg ccgtgccctc gccacgcagg tcaagccgcc agacggagtc
     9301 gacgtcaccc aggtcgaccc tggtcgagct caggcttagg gccgggccgg cgggccgcgc
     9361 agcgaccggg acggccggtg acccgggcgg cggtccggtc cgcggcctcg cggcggtcgg
     9421 ggcaacccgt ggcgaaaccg acccgatgcc ggtgctcggg gaggccgcgg acgcggtgga
     9481 aagggccgga ccggcacccg gccgggcagt gaccggggcc gccgtcacgt ccgccggccc
     9541 gtcctcgtca ccgggcgtgg gtgccggcgc tgcgaccggc gcacccggcc tgcctccgga
     9601 ggaacccgca cgatggtcgc cggccatccg cccacgcaca accaccagac ccgcaacgat
     9661 gacgaccaac acagccacca cagcgatgat gcgtccccac cggatcggca ggatccggcc
     9721 tgaacgcccc cagggagaac ggtgacgtcc cggcgatccc gggccccccg caccatcatg
     9781 cgtcatcgtg acgagattaa gccgacggat tctcgctagg ggaccaattc gctcgtttcc
     9841 gtcacgaagt acgccgagat ctctctcggc cctcgggtcg agacgggatg ccccgattct
     9901 ccccattgac cccgttgtcg ccgttgtcgc cgttgtcgct ggcctcccgg ctctccccgg
     9961 tccgccggct gcgaggcctg ccgggcggcc cgccccgcag ccggcgcccc caccagaccc
    10021 accatgccaa cgtctgggtc accagcgcga agccgaacag cagatcctcg accggagcgt
    10081 gcgcgatccg cgggccgagg atccggcggg ggtcgtagac gacgatgccg aacccggtga
    10141 ggatcccatt ggagatcaac tggaacaacg cgatgatcgc ataggaagtc cagaaaaccc
    10201 gccgggtcag cagccgggtc cgcaggaccc acaggtccat cgcgatcgcc aacgcgaccc
    10261 cgacgaccgc cagggccgtg tagctcacgg ccgatcacca tcgggagtcc catcggaacg
    10321 cgtcgcgctc ggatgggcgg gctcgtcgcc gacgtcccag ccccgcaccg cgcgcacggc
    10381 ctccagcgtc aggatcgcgc acatcggcac cacggcgaag aacagcagct cctccagggg
    10441 aaggcccccc ggaagcagga tcccggtgat gcggcgccgg tcgaagctcc agtgccccgc
    10501 ggagacggcg aacaggtccc agacaacgaa gatcacgatg acgggggcga gggtcagcag
    10561 cagccgaacc ggccgggcgt acacccgggt gcccagaaac acctcaagcg gcgccgttcc
    10621 gagcaggcat cccgccagga ccgcgaggta gctcagatgg cgcatcggcg gctcggacgg
    10681 cgcatcgaca actctcagac agctctcaga cgctgagcga gggcaacagc gctcgcggcc
    10741 ggatcctcga ccccggtgag gccccgcacg accaccacgc ggcgcgctcc cgtcgcaaga
    10801 atctgatcca gggtatccgg accgacgcca ccggtgacga accacggctt cacgcccgga
    10861 gcgaacggag gagcgtgccg cgcggccagc cggggcagac ccaggccgac cggcggccgg
    10921 ccctccttgg tgggcgtggc gtgcaccggc cccacgcaca cgtagtcgac gtcggggtcg
    10981 gcgagcgccg cgaggaactg gtcgggatcg tgcgtcgact gtccgatcag cacgtccggg
    11041 cccaccaggc gccgggcaaa ccgcggcggg atgtcgccct gaccgacgtg caggatgtcg
    11101 accccggcga aggcggcgag gtcggcgcgg tcattcgcgc tgaccagcac tcccctggcg
    11161 ccggcggcgg cctgcacccg ccgcagcccg ccgagctcct cgtcccattc gagccccttc
    11221 tcccggagct ggatcagatc gaccccgggg gcctcgggcg tgccgaccac ggcgctcagg
    11281 aaggcgtcga actcggcccg acgcggcgtg cacaggtaca ggcgggcgtc ggccagccgc
    11341 cgcaaccggt ccgcccgggc tggcccaccg gcgcgcggcg acgatccctc aacctccggc
    11401 gacagcacgc acgatctcca aaatgtcgcc gtcggcgagc cggacggcgg gaatctcgga
    11461 cggcgtcaga gccacgccat tgtgctcgac caccaccgaa ccagacggca ggcccagctc
    11521 ggcgagcagg tcgggcagcg gctggccacc cgggatgccc cgcggcgcac cattgacgac
    11581 gacccgcgcc cgggcgagcg gctccgggtg cgcacgcggg tgcaagtgcg gcggacgatc
    11641 gaccattttt cgaccctacg ggagcagcgc ccgccgtgcg ggcggtgggt acggccggga
    11701 ccgggccggg gctagaaggc cgacgcctgg gcccgccgtt tgacctcctt gccacggttc
    11761 tcgataagtg cctgcatggg ggtgcccggc agactcggat cctcccggaa gatccagtcg
    11821 agcgcatcct catcggtgaa ccccgcgtcg gccagcaccg tgagcaagcc gggcagcccc
    11881 ttgacgacgg cgccgtcccg gatgaaatcg gcaggcaccc gcaggacgcc cccctcccgc
    11941 cgggccagta gcgtccggtc gcgcaccatc tgccggacac gggtcacggg aacctgcagc
    12001 tgatcggcga cgtcaggcag ggtcagccag tccatggtca agagtaaaca cctaagtctc
    12061 gatggcgtcg tatggtgccg gcgcggccgc ggacgttggc cgcgcccctc ggcgagggga
    12121 tgaccaggcg gtttccggcc gggacggtcc ggccggaacg ggtcagagcg cagccacctg
    12181 ggcgccgccc gcggccgccg agcgcaccgc cgcctccaac accgcgacca ccggacgggc
    12241 ggtctgcacg ccgtagccgg acagcggcca gcccgagacg agacagtccg ccaggtcccg
    12301 gtgaaacgta ctgcccgagg tgggtgccag cgggatgtgg ctgcgcaccc cgtcatgggt
    12361 gatcagcacg agcgaccccg cctccgcctc gagtatctcg gcctcggcct cgacctcgga
    12421 ccgacgaccg gcgtgccgtc ccaaccgcgg caccagcttc ccctccccgt cccggaaagc
    12481 cccgccgtcc cggaaagccc cgtccaggat cagcgagccg gtggacccga gcacctcgaa
    12541 ccgcgggcgc cgggccaccg tcagatcgga gaccgtgacc tgcgcctcgg ccccactcgc
    12601 gaaacgcagc agcagccggc tgtggtcagc gttgctgacg tggtgccaga cccgcttgac
    12661 ggtggacgcg ctgacccatt cgacgggctc gtcaacgagg gcgaggatct ggtcaacgca
    12721 ggcgctgccc cgatcatgga gctgcccacc actgatccgc tcgtcgtcgt gccaggtgcc
    12781 ggctggccgg cggaagccgc cccggtgggc gtccagccgc agcggctcgc cgacggcgcc
    12841 gcggtgcacg gcggcgcgga ccgcccggta gcccgggtcg tcccgaccct ccggatacac
    12901 cgcgagcacc agggaccggg cctccgcgag ctccgcgagc tggtcggcgt ccggggtcga
    12961 caggcagagc ggggcgtgca cgacgacgtg cttgccggcc tccagcgcac gaccagccca
    13021 ttcgagacgg gtgtgggtcg gtgtggccac gatgacgacc ccgagatccg gatcgttgac
    13081 caggtcgtcc gggtcgtcga cgcggcgcgg cgggcgaccc gccgcgtgcg ccgggagccg
    13141 gccggcaccg ccgtcgcaga gggcggcgag ttccaggccc tcggtcgcgt ccaccgccga
    13201 gtggtgcgtc ccggtgatgt ccggggtgcc cagcagcccg accctggccg gcgcggcgtc
    13261 gagcacgccg aggcagtgcc gcagccaacg tcccacgagc cgctggtagg cgggatcggc
    13321 gagcacggcg ggaccggtac ccagggtgaa tatgccgagg cccgtggagg gccgccaggt
    13381 gcagacggga tgctcgccca tctcgtgccg gaccaggagc agccgctcca cgtcgtcggc
    13441 aatcttgtcg gggatgatcc agctctcccg ggggcggaag tccgcggacc gggccatgac
    13501 cgcgccgccc tgcggcccga cggtcaaccg caggtcgtag ggcgcggtgg tccgccccgg
    13561 gatgaaaccg gacgcctcga tgagcggact tcccggcggc agcgcccgca tggtcggccc
    13621 ggcgagcagg accgggacgg tctgccgggc ccggtccagc aactcctgct cgacgtggtc
    13681 gagcggacgg tcgatgagca cgagaagcgc gtcggccgac cgtgccgagg tcgggccgag
    13741 acccgctgcc cgcaaatggt cgccgagcgc gttcacaccg gccaggttcg acaccaggtg
    13801 aatgcgaggc acgtctccgc actctagtga ctgttcccga cgttccggcg attggggtca
    13861 tcaaacaaag atccaaataa agatccgcgc aaagatttac acaaggatgc atacataacg
    13921 caatgccggg caagagtacc aatgatcctg atatccagaa atcccgccgt ccggccgatc
    13981 ggaacgcctg gaacgcctgg aacgcctgga aaatccggag caccgggaac accgggtcgt
    14041 caccgggcgt catcgacttg ccgcggccag ttccttcatc gacacggaga tatcggcgaa
    14101 acgctcccga tccgggatac cgtcggccgc catcaaccgg cgaccggcga ccatgtccat
    14161 cgggcgcccc acagtgacca gcgcctcgag acggccgtcc ggggcgaacc acccggccga
    14221 ccagccagac ggacgcccgc cgtcgggcgg cacgacgacg cccggatcgc cccggaacac
    14281 cggggcagcc tctgccgaag ggagtcccgc gaactgcacc atgcggccga actgttccga
    14341 ccagaagtag ggcaccgggt catagacggc ctccccgccg agcagcgtgc tgaccgcgac
    14401 cgcgggcgac tgctgggcgc agtcccagtg ctcgacccgc agccgccgac cgtagcgacg
    14461 cgaccaccaa gcagcacagt caccgaccgc gaccaccggc ggccggtcgc cgtcggcacc
    14521 gtcggcacca tgggtccacc gggcggcgag atgctcgtca accacgactc cccggtcgag
    14581 ggcgagcccg gaaccggcga gccaggcggt gccgggccgc accccgacgc cgacgacaac
    14641 ctcgtccgca atcagctcct caccgccagc cagcaccagc ccgtcggggg tgacccgctc
    14701 cacggccgtg gccaggcgca gggtaacccc ggcccgggcg taccacgcga tcgtgcaccg
    14761 gcccacctgc gcgccgagcg cggcgaacag cggcgaggcg gctgcctcca cgacggtgac
    14821 ctcggcaccg atcgctgccg ccgccgtggc gacctccgcg ccgatccagc cggcaccaac
    14881 gatgacgagc cggacgccgg gacgcagggc gccacgcaga tcccgggcgt cgtcaatgga
    14941 acgcaggacc cgctgtgggc cgtcgcccgg cagggttacc gggtcggctc ccgtcgccag
    15001 caccaggccg tcgtagtcca gcggccccgc gtcggtctcc acagtgcccg gtcgcaggcc
    15061 cgtcgcccgc cgtccgaggc gcacctcgac cccgtcgagg tcgaagggca acgtcgtgtc
    15121 gtcgatgcgg ccggagagca ccgccttgga cagcggcgga cgatcgtagg gccggtgcgg
    15181 ctccgccccg agcaggatca cctctcccgc gaaaccacgc gcgcgcacct cggcggcggc
    15241 ccggcccccc gccattcccg cgcccacgac gactattcgc tgcattcgag cagactatcg
    15301 acgacccgcg acgccgggcc gccgtcaccg caccgggtcg acaagcggaa aggcgtcctt
    15361 ccacaccggc tcgtacccgg cttcggcgag catcgcggcg atctgtgccg gcgaacgctc
    15421 gtcggagatc gagaactgtt cctgggccgt gccgggcgtg gtgtagccgc cgggttcggt
    15481 ggaggagccg gcgctcatgg tggtcacggc gatgcggacg agcccgtcgc gcagcaccgc
    15541 cggctcccgg gtcgacagcg acagcgcgag gtccggctcg aacaggcgca gggccgcgta
    15601 cgcctggacg aactccgcgt cgtcaacgac gacgaccggc gggaacccgc tggcactcgg
    15661 cttgatgcgc ggcagcgcga tcgagacctc ggtccgccag tagcgacggg agagaaagga
    15721 ggcgtgcgcg gccagcgcga gcacgtcagc gcgccagtcc ggggcgagcc cgagcagcgc
    15781 gccgatcccg agccggcgca ccccggcccg cgcggcccgt tcgaacgagg acagccgccg
    15841 gtcgtagtca cgcttccagc cggcgacgtg cacctcggcg tagcgggccc ggtcgtaggt
    15901 ctcctggtaa tggacgactc cctccaaccc ggcacgcacc agccgggcat aggtgtcgtc
    15961 cgaccaggtc tgggtctcga tgctgatcga ggggaacatc ggccgtagcc gctcgaccac
    16021 cgcgacgagg tagtcggccg atacctcgac gcgatgctcg ccggagacga gcagcagatg
    16081 acggaacccc cggtcgacca gcaggcgtcc ctccgccacc acctcctcaa ggtccagcgt
    16141 gcggcgcacc accggcaggc ccttggcgaa gccgcagtag gtgcaggacg acaggcaggc
    16201 gttcgacacg tacatcgggg cgaacagccg gaccgcccga ccgaaccgga gcagggtcgc
    16261 ctcccgggcg gcaatcgcca gctcctccaa ccgggcggtg gccgcgggtg agagcaggat
    16321 cgccagctcc gcgagaccga tccggggggt ggccgaccca ccggatccgg gccgaacccg
    16381 ccgcagcacc gtgtccacct cggcggacgt ggcccgccgc gacatcgcgg acagcccggc
    16441 caggtcgtga ccggcaagtt cgcgcgcgaa ctcccctggc ggggcgctca cctggacgcc
    16501 tcgcccacca ccgcagccgg ggacgtcgcc cgggacaccg agggcacggg cgacgccggt
    16561 gacgggtggg acgccggtga cgggtgggcg ccgaggaacc cggtgagcgg ggaggaggcg
    16621 gacgccaccg tggccgggcc ggcagcccct cggccggcca ggaaacccaa ccggccggcg
    16681 gcggtggcga gcgcgaaggc ccgcgccatg cgcgccggat cggcggccac cgcgatagcg
    16741 gtgttgacca gcaccgcggc cgcgccgatc tccatcgcct cggccgcgtc cgagggcacc
    16801 ccgagcccgg cgtccacgac caccggcacc ccggcgctcg ccacgattgc ctcgatcgcg
    16861 tcccgggtgc gcagcccgcg gttcgagccg atccagctgc ccagcggcat cacggtggcg
    16921 cagccgacct cctccagccg gcgggccagc accgggtcgg ccgaacagta gggcaggacc
    16981 gtgaagccgt cggccaccat gagctcggcg gcgcgcaggg tctccagcgg atccggcgcc
    17041 agggtgcgcg gatccggggt gacctccagc ttgaccagac cggtgcccgt cgccgcccgc
    17101 ccgaggcggg ccagccgcag cgcctcggcc gcgtccaccg cgcccgaggt gttgggcagc
    17161 agggtcatcg acggcgggat gaagtcgaga acgtcgccgt caccgatccg gccgatgtcg
    17221 acccggcgca gcgccacggt gacgatggtg gcaccggatg cgacgaggct gtcccgcatc
    17281 acccggtgac tcgcgaactt cccggtgccg atcagcagcc ggctgccgta ggcccgcccg
    17341 gcgatgacga gatcgtccgc ccccgcggca ccgggtccgg cctcaccacc acccccgccg
    17401 ccgacggcgg aacctccacc ggcgaggcca tcgggacagg aaccgtcggg gggagaatcg
    17461 ccgggacggg aaccggcagg acgtaggggg tgctgcgaca cgatctttca tcctccccac
    17521 gcgcgcatga ccgcgatcgg gtatacgggt cgccgacggg atactggcca gcctctcagc
    17581 ccacgtccgt gggctccccg gagcaatcga cagtgtaacc gctgcttcct ggccgcggct
    17641 tcgggtgtcc cgccgcgacg ccgatctgcg acgccgatct gcgacactga tccacgcccg
    17701 tcgacgatca tcgcggcctt gagaaccgat tcaatgtggg cacccgggtt tcacccggtg
    17761 gacaccatgc tgcgcgacga ggtacttctc gctcgaacga cgtatccggg ttaacctcgc
    17821 ggggctcggt agcggcatcc ttcgacaacg atcgtaaact ctccctcgtg gatgccaccg
    17881 tggccgaccc cgtcgtaggt cggcttctcg acggccgcta cacggcgcag gaacggctcg
    17941 ccgtcggcgg gatggcgacg gtgtacgtcg cgcacgacaa ccggctggac cggctcgtcg
    18001 ccctcaaggt catgcatccc actctcaatc acgacccgga gttcgtcacc cgtttccatc
    18061 gcgaggccaa ggccgtggca cggctcaaca ccccgcgcgt cgtctccatc ctcgaccagg
    18121 gttccgacca catccccgcc ggtctggtca actacctggt gatggagctg gtgcgcggcc
    18181 ggtcgctgcg ccagcacctg ggcgcccggg gtcggctccc ggtcaccgag gccatcgaga
    18241 tcatcgagcc cgtgatcgag gccctcgccg ccgcgcatgc cgccggcatc atccaccgcg
    18301 acatcaagcc cgagaacatc ctgctcggtg acgacggcca ggtgaaggtc gcggacttcg
    18361 gcctcgcccg tccggtgagc cagcccaccc aggcactcac cggcggcgtg gtgatgggca
    18421 ctgtcgggta cctcgccccc gagcaggtca cccacggcgt cgccgacacc cgcagcgacg
    18481 tctacgccgc cggtgtggtg ctcttcgaat ccctgaccgg gcagctcccg cacagcggcg
    18541 ccaccccgat gtcggtggcc taccagtcgg tccacggcga cgtgccggcg ccgtccacca
    18601 tgatcgaggg cattcccgcc gagctggacg gtcttgttct ccgggccacc gcccgcgacc
    18661 cggcgcgccg gccggtcgat ggtgcggccc tgctggcgga gctgcggcgc atcgagccgt
    18721 tcctgccccc gcaggacgcc tacccgagcg ggttcaccgg cgagatcgaa cggatcgggt
    18781 tggccgagcg gccttcaggg gcccgggagc ccgggtaccc ccaggagccc gggtacaccc
    18841 agccgttcca ggccgaggac tacgacgact cccggggcgc cgggccgggg gccgccgcgg
    18901 agcgcgcgtt cgccggtgcc gggccgggcc agccaggcac cggcgcgctc tatcgatccg
    18961 cctccccgcc ctcgccgacc gccacggcct atctcggggg cggtggcggg cgcgggcggc
    19021 gacgggccgc cgcatcgcca cgctcccgag ggctcatccc ggtcgtcgtc ggtggcatgg
    19081 ccgtcctggt cctgctgctc gggatcctcg cgttccgttc cctgtccggc ggagggaccg
    19141 aggtcccgct gctgacgaac ctgagcagat ccgacgccga gaaaatgctg cgcgacgccg
    19201 gcttccagtt cacctacctc gacccggtcg ccagcgccac ggtaccggtc ggccacgtcg
    19261 cccagcagga tccccgggac ggatcgaagg tcgacaaggg cgcgctcatc accctgcggc
    19321 tgagctccgg ccccgcgacg gtgcgcgtgc cggacctggc gaacctcacc gagacccagg
    19381 ccaaggcccg gctggccgaa gtggacctga ccctcggcgg cctgagccca cagtccagtg
    19441 acacggtgcc ggcgggccat gtgatcggta cgaaccccgg ggccggcacc gcgctcaagc
    19501 cgaaggacca ggtcgtcgtg atcacttcga cgggccccgc gacgaagccg gtgccggccg
    19561 acatcatcgg caagtcgttc gaggaggcca aggccgagct cgtcggcctg aacatcggcc
    19621 tcgtggtgca gcgcaccgac gccgtgaacg acgccgtgca gcccggtgag gtcttcgggg
    19681 tctctcccga cgtggggcag ccgatctcac ccggcggcac cgtcaccctc accgtagccg
    19741 aggccgacgg gttcgacaac ggtgacggtt ccgggggcga cggcagcggg atccaggtcc
    19801 cggtgccgaa cgtggtcggg aagagctacc gggaagccga gaacatcctg cagcgccggg
    19861 ggttgaagat tgaccgtatc ggctggatcg gcgggccggg cgaccgggtg acatcgcagt
    19921 ccgccaaggc cgggagcaaa atcgaaaaag gaagtaccgt gcacgtcaac acaacgtggg
    19981 accccctcgg ctgagccgcc atcctccacc aggttgatca tattgtgcaa cgaatcgcgc
    20041 ggtgggcgaa agatccgcga ccgcttcccc ggggggacga cggcgtgaag gcagcgcgtg
    20101 gtcgtggccg gtggcccgcc ggcccgcggc ggccgacgtc gtggtggcgg gagtcgtcgt
    20161 ggtggcggga gtcgtcgtgg cggggcatgg ccggcggtgg acggcgggcc gagcgggtcg
    20221 ccgacctgct ggacggacag cgccccccgt atgacgagac cgacgcgcgg ctgatcgaca
    20281 ccgtggcggc cctccgggac ctgccgtcac cgcggctgca tccggcacgg cacgccgccc
    20341 tgcgcggaca gctgttcgcc gccgtcaccg gctccccggc atgcgatccc gtccgttccc
    20401 ccgccgccgt ttcccccggc acctccgtga agggccacga gaccgaggcc cgtcccacaa
    20461 gaacccgtcc cgcacgcacg cctcccgagg gcgtcgatcc tgacctgccg ggaaacgatc
    20521 cggtcgacgc gcggtgggta cgccggaccg gtgcccgcgg tgtctctgcc tgcggtgtct
    20581 ccggccgggg caggatgacc cgggccgccc ggccgctgct ggccggagca ctcaccgccg
    20641 ccgtcaccac ggcggccctc gcggt
//
