LOCUS       NC_007777              25189 bp    DNA     circular CON 05-SEP-2024
DEFINITION  Frankia casuarinae, complete sequence.
ACCESSION   NC_007777
VERSION     NC_007777.1
KEYWORDS    RefSeq.
SOURCE      Frankia casuarinae
  ORGANISM  Frankia casuarinae
            Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
            Frankia.
REFERENCE   1  (bases 1 to 5433628)
  AUTHORS   Normand,P., Lapierre,P., Tisa,L.S., Gogarten,J.P., Alloisio,N.,
            Bagnarol,E., Bassi,C.A., Berry,A.M., Bickhart,D.M., Choisne,N.,
            Couloux,A., Cournoyer,B., Cruveiller,S., Daubin,V., Demange,N.,
            Francino,M.P., Goltsman,E., Huang,Y., Kopp,O.R., Labarre,L.,
            Lapidus,A., Lavire,C., Marechal,J., Martinez,M., Mastronunzio,J.E.,
            Mullin,B.C., Niemann,J., Pujic,P., Rawnsley,T., Rouy,Z.,
            Schenowitz,C., Sellstedt,A., Tavares,F., Tomkins,J.P., Vallenet,D.,
            Valverde,C., Wall,L.G., Wang,Y., Medigue,C. and Benson,D.R.
  TITLE     Genome characteristics of facultatively symbiotic Frankia sp.
            strains reflect host range and host plant biogeography
  JOURNAL   Genome Res 17 (1), 7-15 (2007)
   PUBMED   17151343
REFERENCE   2  (bases 1 to 5433628)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,J.C.,
            Glavina,T., Hammon,N., Israni,S., Pitluck,S., Goltsman,E.,
            Martinez,M., Schmutz,J., Larimer,F., Land,M., Kyrpides,N.,
            Lykidis,A., Francino,P., Benson,D.R., Huang,Y., Mastronunzio,J.,
            Bickhart,D., Niemann,J., Rawnsley,T., Tisa,L.S. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2006) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000013345.1-RS_2024_09_05
            Annotation Date                   :: 09/05/2024 02:41:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,755
            CDSs (total)                      :: 4,702
            Genes (coding)                    :: 4,516
            CDSs (with protein)               :: 4,516
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 53 of 186
            Pseudo Genes (incomplete)         :: 162 of 186
            Pseudo Genes (internal stop)      :: 10 of 186
            Pseudo Genes (multiple problems)  :: 37 of 186
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:46:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2378536
            Orig. end                         :: 2403725
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000249.1.
            URL -- http://www.jgi.doe.gov
            Source DNA and bacteria available from Louis Tisa
            (lst@patia.unh.edu)
            Contact: Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-PGF
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25189
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="11"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25189
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25189
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15189](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15189)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    302..317
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.16"
                     /tool="antismash"
     misc_feature    852..866
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(1232..>1396)
                     /locus_tag="FRANCCI3_RS29010"
                     /old_locus_tag="Francci3_2024"
                     /pseudo=""
     CDS             complement(1232..>1396)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005463988.1"
                     /locus_tag="FRANCCI3_RS29010"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2024"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="ERLGRHRWKGERTISWLDGYRRLTIRYERDGRNFLGFLTLAATIT
                     CRKKLPPPT"
     gene            1633..2456
                     /locus_tag="FRANCCI3_RS24425"
                     /old_locus_tag="Francci3_2025"
     CDS             join(1633..1984,1984..2456)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009332786.1"
                     /locus_tag="FRANCCI3_RS24425"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="Francci3_2025"
                     /product="IS5 family transposase"
                     /protein_id="WP_085949870.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MDVLGSSLAGRLVPDELWELVEPLLPRFEARWQGGGTAPIEDRAV
                     FTAVVYVLTSGCAWRHLPSEFGVSVPTAHRRFQAWTRAGVWPRPHRKILDLHGVAGRVD
                     WSSAIVDAASLRAKKGGSLTGPNPVDRGKPGSKIHVLTDAGGLPLVVAVSPANPHDSGA
                     FVPLVASIPAIRSRRGPRRRHPAKLRADKAYDQPERRRFLRRRGIAVRIARRGVDSTER
                     LGRHRWKVERTLAWLGGYRRLTIRYERNGYNFLGFLCLAAAITCWKKLPHST"
     gene            complement(2478..3086)
                     /locus_tag="FRANCCI3_RS10185"
                     /old_locus_tag="Francci3_2026"
     CDS             complement(2478..3086)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436457.1"
                     /locus_tag="FRANCCI3_RS10185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2026"
                     /product="heme-binding beta-barrel domain-containing
                     protein"
                     /protein_id="WP_011436457.1"
                     /transl_table=11
                     /translation="MTKTTGKPGKTEKAGKVGPEFGPLAALAGAWEGDQGVDVAFGNAE
                     GTIIETPYRERVTFKPFGPVDNGPQCLYGLDYHMAAWRAGEEKAFHTEIGYWLWDANLG
                     HVMRCFMVPRGAVLIAGGAVAPDATDFTLRAQAGSPTYGILSNPYLARAANSIRYEVSI
                     TVTGNGSFAYTSTTTIDHERVSDPVAHTDRNVLRRLSDA"
     gene            complement(3308..6823)
                     /gene="nifJ"
                     /locus_tag="FRANCCI3_RS10190"
                     /old_locus_tag="Francci3_2027"
     CDS             complement(3308..6823)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016903 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0022900 - electron transport chain
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nifJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436458.1"
                     /locus_tag="FRANCCI3_RS10190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2027"
                     /product="pyruvate:ferredoxin (flavodoxin) oxidoreductase"
                     /protein_id="WP_035959116.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.4e-10, bitscore:
                     36.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQKTIDGNEAAALVAYLASEVIAIYPITPASAMGELADAWAAKG
                     RPNLWGAVPEVVQLQSEGGAAGTVHGALQAGALSTTFTASQGLLLMLPNMFKIAGELTP
                     MVLHVAARTVATHALSIFGDHSDVMAARSTGFAMLCSASPQEAHDLAAVAHAATLESRV
                     PFLHFFDGFRTSHELNEVALLDDGTLGGLLAAGHIDAHRRRALSPDRPVIRGTTQDPDT
                     FFQAREASNTFYAAVPGIVQGVMDRLAAATGRAYRLFEYQGHPEAERVVVVMGSGRSAV
                     REAVTRLVERGERVGFVQVRLFRPFDGRALLACLPSTVRSVAVLDRTKEPGASGEPLRL
                     DVVAAFAERPERMPRVIGVRYGLASKEFTPAMAAAVFDELAGAAPRREVTVGIRDDVTD
                     LSLEVDDDRVPEPDDVLRAVFYGLGSDGTVGATRATAGIVAARTPLHAQAYFVFDSKKS
                     GSMTVSHLRLSPRPVDSPWLIQNAQYVGCHQSSLLERVDVLAVAAPGATVLLNSPHAPE
                     KVWEHLPADAQRHLLDRDARLFVVDADRVAKQAGMPGIVSPVLQTCFLALSGLLDRDEA
                     IAAVKDGVRAARGKRGDAVLQRNFAAIDAALDALHEVDLQARVVTGQARRQLLGEAPAF
                     VRQVTARIMAGEGNLLPVSALPADGTFPVGTARYEKRGLTRELPVWDADLCIDCGKCAI
                     SCPHAAIRMTLFDPARLADAPASFRHKKPKDRTLAAFRLAVQVAPDDCTGCGICVEACP
                     AKSREIEGHRALDMVDAAPRFEEERAGWAFRETLPAVPPALAPPDTVRGSQLREPLFEF
                     SGACAGCGESPYLKLLTQLFGDRIIVANATGCSSIYGGNLPTTPWSAGTDGRGPAWANS
                     LFEDNAEFGLGIRLALDSRAREARRLLRAQTATVGGTLVEALLTADQSTEAGILDQRQR
                     VAELRRRLATVDHDTTLDAVLDDLVDKSVWIIGGDGWAYDIGFGGLDHVLASGRDVNVL
                     VLDTEVYSNTGGQASKSTPRAAVAKFAGGGKRTRKKDLGLLAAAYGDVYVAQVALGAND
                     QHTVKAFNEAASWHGPSLIVAYSHCIAHGITMTDGLAHQKAAVKSGYWPLYRVDPRAER
                     PFSLDSRAPSIPFSEFAATESRFTLLNTVNPDEADELAALAQRDILGRWQTYEHEAAHP
                     RHTTT"
     gene            7042..8010
                     /locus_tag="FRANCCI3_RS10195"
                     /old_locus_tag="Francci3_2028"
     CDS             7042..8010
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1157: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436459.1"
                     /locus_tag="FRANCCI3_RS10195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2028"
                     /product="ParA family protein"
                     /protein_id="WP_011436459.1"
                     /transl_table=11
                     /translation="MKAVAIASYKGGVGKTTLTANIGAAIARLGRRVLMIDLDPQANLT
                     FSFYRPETWRTDLADHRRTVKAWFESWRPETTPPPLAGYVTTPSVVNAAVAAGGGTLDL
                     LASHLSLGDIEMDLTARLGGARAHRSTRYYFDVYQRLATGLASFSTYDYDLVLIDCPPN
                     FGVITRAAIAACDHLLIPARPDNLSTLGIEHLMSRLGRFVWEYNRVAGLQSGMHPAVKR
                     LEPRVLGVVLMMVQYYGGRPTSFLRPYIHQASGLGLPVFESMLRVSNRSFAGAAGTQLP
                     AVLSADLPPEVARELISLVEEFLRRVGAASRMAGPSHRPVA"
     tRNA            8225..8309
                     /anticodon=(pos:2386794..2386796,aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FRANCCI3_RS10200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="Francci3_R0033"
                     /product="tRNA-Leu"
     gene            8225..8309
                     /locus_tag="FRANCCI3_RS10200"
                     /old_locus_tag="Francci3_R0033"
     gene            complement(8274..8669)
                     /locus_tag="FRANCCI3_RS27975"
                     /old_locus_tag="Francci3_2029"
     CDS             complement(8274..8669)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020460320.1"
                     /locus_tag="FRANCCI3_RS27975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2029"
                     /product="hypothetical protein"
                     /protein_id="WP_082456821.1"
                     /transl_table=11
                     /translation="MRAVGMSHDEIAIEFARRYHYRPRAAHRHARGWTQTQAANHINAH
                     AARAGLDPDGAAPMTEQEIHDMVTAVGDIVAVLTEADPADKAEIYTQLGLQLTYEPGAH
                     RVIAEAKPQGIMYERECPRGDLNPHAR"
     gene            complement(8853..10004)
                     /locus_tag="FRANCCI3_RS10205"
                     /old_locus_tag="Francci3_2030"
     CDS             complement(8853..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436461.1"
                     /locus_tag="FRANCCI3_RS10205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2030"
                     /product="hypothetical protein"
                     /protein_id="WP_011436461.1"
                     /transl_table=11
                     /translation="MTNVGTDPADENLLAWFPLVQRPRPPGLPLEDRVRQLHDLAARTS
                     DGLPLLRAAEVCNKAALIASDCGQPDLAQDLCWRQHTLFDQARPLPASAAELALQPVLN
                     LPRQLIRDGDGNRAHAILQALHEAARTQTSALIDGRSVSLHNVTCASDDHRTMRTLTWT
                     ALLADGVRALARAGRWHEAAEQAAAHRGVGRRLLDGRQATVLALAQAGHTEQAAALVDQ
                     SATPEPWEQAIQTILRVHCLRQAGADTGPQIAPLLATALTLMRQPDLSTMVFRARAGMI
                     ALDLADGHDHPRIDVLRRALIAGTFKDAYTARDTLAHRLRESMTTTQRQTLADVFRAAG
                     LDAGSIPESLYGDLMETVKFAEDQLRGCLGRHARHCECTTATS"
     gene            complement(10001..10846)
                     /locus_tag="FRANCCI3_RS10210"
                     /old_locus_tag="Francci3_2031"
     CDS             complement(10001..10846)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436462.1"
                     /locus_tag="FRANCCI3_RS10210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2031"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_011436462.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-41, bitscore:
                     141.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTRTWHQVNVTFPDWANAEGTAVDHLAPLLDTAETDGLITSWFF
                     VRKAPCWRIRYLPRQTTGEAKAYIHTRLADLRETRRIEDATSTLYEPESHAFGGAEGMD
                     TAHRLFHLDSRHLLTYLNSTSHKPADRRRRELSVLLCSHLLRAAGLDWYEEGDVWARVA
                     EHRQPPERTPDDRLRTLRDGLRRLMSIDTDSLAKDTLPPAFTDWTSDFAAAGTELAALA
                     TDGRLRRGLRAVLAHHIIFAWNRHGLPHTAQAVLAHTAKTVVFGHDPASDHQPHDREPA
                     "
     gene            complement(10859..12097)
                     /locus_tag="FRANCCI3_RS10215"
                     /old_locus_tag="Francci3_2032"
     CDS             complement(10859..12097)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006541251.1"
                     /locus_tag="FRANCCI3_RS10215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2032"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_011436463.1"
                     /sec_met_domain="LANC_like (E-value: 7.1e-40, bitscore:
                     135.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSDPDALAAANTVAEALADPHTAWAAHRPTGGRAWPQSLAGGA
                     AGIALLHIERARSGYGDWSTVHAWLSAAASDALTAAANAGLYLGAPALAFTLHTAAGPS
                     GRYHRALAHLDQAVVAMTRTRLAAAHTRIEQSRRPAMKEFDLIRGLTGLGVYHLRRHPD
                     HPITGELLSYLVRLTEPLAGRDDLPPWWTDSAPNGEPSPEFPQGHGNVGLAHGISAVLA
                     LLALAHLRGLPVRGADDAIARICAWTDRWCQHGDTGPWWPGFITLRQVREGKVAATLRP
                     RPSWCYGVSGTARAQQLAGMALRDTARQQAAENALLAALRDEAQLDQLTEIGLCHGTAG
                     LLQSAWRMAADSHHPQLTAELPGLSARLIAQMGTTVRDPELLDGAAGAALALHTAGTGA
                     APTSGWDAFLLLA"
     gene            complement(12094..15189)
                     /locus_tag="FRANCCI3_RS10220"
                     /old_locus_tag="Francci3_2033"
     CDS             complement(12094..15189)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436464.1"
                     /locus_tag="FRANCCI3_RS10220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2033"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_011436464.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.4e-194,
                     bitscore: 646.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3e-17,
                     bitscore: 61.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-34, bitscore:
                     117.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQHLDSLVVRAAVNPPVDVAERWPDLVGPAATPESWRLWLREVM
                     QNRAFEMALEQASPVLARRVREIRDGRQVPQAGVRRAVLSVMRYRLRASGRATPFGLFA
                     GVAPVRVADHASVRAGVAHRAVARVEAGWLCAVVDRLEADPVVRARLDVVANNLVFERD
                     GHLVLEHRAAGGTDGVPTRVQVRAHAPVRAAMGIGRRSVRFSDLAARLASEFAPVPADV
                     VDRLLADLVAQRFLLTNLRPPMTASDPLRHVVGVLQTTLNGGPVTVEAAWVAERLNGIV
                     DGLRSHDSASSWTVARSSRERLGEDMAEVHPSAEPALRVDLRMDWALAVPRAVAVEAAA
                     AAGVLVRLARRSTLSSGWDAWHGRFLERYGPCALVPVFDAVDPEIGLGYPAGYAGSPAP
                     AGVTFTDRDAKLLALAQNAALRREREIVLDDRMISDLTVVDQDAHVQPTTELTLRVHAT
                     STRSLDDGAFTLAVVGVSRRAGTTTGRLLDLFDAKDSARMRALYAGLPTASRDALSVQI
                     SAPARYTNTDTVGRAPQIMAHRLSLGEYDDSEDGDSLPLDDIVVTADVHRIYLLSLSRR
                     QLVEPVALNAVEPVRRAHPLARFLAEAPAALSVPCAPFDWGVAAQLPFLPALRHGRTVL
                     SPARWLLGTADLPGSAAGWTEWDRALASWREQVNLPSAVYLGDGDQRIGLDLSEPAHRV
                     LLRSHLDRSGAALLRAAPDTDAAGWVSGHAHEIVVPLAAVAAPAATPGWFSRAQVVGRD
                     HGHLPGCDARFSVKIYAGLGCQDDILTRHLPHLVHELNGQQAAGEARWWFLRYHDPDDH
                     LRLRLAVTADGVAPTADRIGAWTQRLRRAGLISRAQWDTYFPETSRFGGTAAMDAAEAY
                     FAADSAAALAQLAASREKSGPDRRALTAASMLAIVTGLIGDTAEATSWLISHTRTEPSA
                     PARALYQQTVALANPADPRALAAQPGGEHVLSCWAHRREALTAYRHVLQETRAEAPTSL
                     LPDLLHLHHVRMAGVSLAGERACLHLARAAALSWTARTRNPS"
     aSDomain        complement(14461..14733)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FRANCCI3_RS10220_Lanthipeptide_LanB_R
                     RE.1"
                     /evalue="1.80E-19"
                     /identifier="RREFam001.1"
                     /label="FRANCCI3_RS10220"
                     /locus_tag="FRANCCI3_RS10220"
                     /protein_end="243"
                     /protein_start="152"
                     /score="61.2"
                     /tool="antismash"
                     /translation="VVANNLVFERDGHLVLEHRAAGGTDGVPTRVQVRAHAPVRAAMGI
                     GRRSVRFSDLAARLASEFAPVPADVVDRLLADLVAQRFLLTNLRPP"
     misc_feature    complement(15067..15069)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15275..15469)
                     /locus_tag="FRANCCI3_RS10225"
     CDS             complement(15275..15469)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006541249.1"
                     /locus_tag="FRANCCI3_RS10225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_023841893.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.6e-16, bitscore:
                     57.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIQLDDPVLAVPPQAGRDQEEDFTTWDLDISIVESGPAADRLIR
                     MTDDGCGTTCETACSTTCP"
     CDS_motif       complement(15347..15469)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSIQLDDPVLAVPPQAGRDQEEDFTTWDLDISIVESGPAAD"
                     /locus_tag="FRANCCI3_RS10225_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15275..15346)
                     /prepeptide="core"
                     /locus_tag="FRANCCI3_RS10225_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-4.20"
                     /molecular_weight="2309.6"
                     /monoisotopic_mass="2308.0"
                     /core_sequence="RLIRMTDDGCGTTCETACSTTCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSIQLDDPVLAVPPQAGRDQEEDFTTWDLDISIVESGPAAD
                     "
                     /leader_location="[15346:15469](-)"
                     /alternative_weights="2327.6"
                     /alternative_weights="2345.7"
                     /alternative_weights="2363.7"
     misc_feature    15513..15526
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            complement(15540..16766)
                     /gene="fxlM"
                     /locus_tag="FRANCCI3_RS10230"
                     /old_locus_tag="Francci3_2034"
     CDS             complement(15540..16766)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006541248.1"
                     /locus_tag="FRANCCI3_RS10230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2034"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_011436465.1"
                     /sec_met_domain="PCMT (E-value: 2e-43, bitscore: 146.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVQDSSATDSAATLRAAMVDELRTTGDAIKTGQVAAAVGRVPR
                     HLFAPDEPLEAVYAANKALVIKRDGNGAALSSLSAAHIQAVMLEQAELEPGMRVLEVGS
                     GGYNAALIQEMVGDGGSVTSVDIDQEIVSRARACLDAAGYRNVEVVAADAEAGVPEKAP
                     YDRIIVTAGAWDIPPAWQEQLTNGGRLVVPLRLRGLTRSIAFDRVDEDGDVGLVSRSYR
                     LCGFVPMQGIGTFRERLVPITDEVVLRVDDPSQEFDVEGLRDALATPRLERWSGAAFDL
                     PDELEFFLVTNLAQVAHLHVDETQVQNGRFAPSAARGVPTLVSGGSFAYRTKRPNEKTG
                     GFESGVVAHGPDADRVAEHYVELLRRWASDHRRSGAAHIRYVPKAAGTPAPSVGLVPKR
                     HGAVAVRWP"
     misc_feature    17022..17036
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    17876..17890
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    17883..17897
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.52"
                     /tool="antismash"
     gene            17903..18961
                     /locus_tag="FRANCCI3_RS10240"
                     /old_locus_tag="Francci3_2035"
     CDS             17903..18961
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436466.1"
                     /locus_tag="FRANCCI3_RS10240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2035"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_011436466.1"
                     /transl_table=11
                     /translation="MRLLILGGTWFVGRVLAEDAVGRGWAVTTFNRGRSGPDVAGVHPL
                     RGDRTDVQDLERLAAAGPWDAVVDVGGAEPRSVGLAAQVLGAQAGRYVFVSTVSVYRDW
                     PASPVDESSPLHPGNPDLVVEDPRWDAVRYGPHKAGCEAAVRRSVSPDRLLMVRPGVVL
                     GPYEYVGRLPWWLRRMARGGRVLAPAPADRPIQPVDVRDLASFLLDLIGRSASGIFNVA
                     APTGHATYGRMLDACAAATRDVRGADEIEVVWAEPDWLVEQGVRQWTEIPLWRVQPGTW
                     RLDATRAAAAGLRCRPIEKTVLATWAWLAAGGAPVRHERQDEHGFDPDRERRLVDLWEC
                     RSQAASGEKGLV"
     gene            complement(18991..19434)
                     /locus_tag="FRANCCI3_RS10245"
                     /old_locus_tag="Francci3_2036"
     CDS             complement(18991..19434)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011438373.1"
                     /locus_tag="FRANCCI3_RS10245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2036"
                     /product="hypothetical protein"
                     /protein_id="WP_011436467.1"
                     /transl_table=11
                     /translation="MTSGVPVREVLEQIEARRARAGRAVEKLREEIARLTGQLAAAERA
                     LERLEITRETVLDLAAENDAAPAEPLPPGYREVLAVFTRGGNGLHAKDVCRALGGGTEP
                     RHVESMRARLKRLVERGVLTEPDPGLFVLPQPDPPATPEINSS"
     gene            complement(19453..20289)
                     /locus_tag="FRANCCI3_RS10250"
                     /old_locus_tag="Francci3_2037"
     CDS             complement(19453..20289)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011435557.1"
                     /locus_tag="FRANCCI3_RS10250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2037"
                     /product="IS5 family transposase"
                     /protein_id="WP_011435557.1"
                     /transl_table=11
                     /translation="MAERKPYPSDLSDEAWDLIRPVLTAWKARHPSASGHEGGYDMREI
                     VNAVLYQARTGCQWRYLPHDLPPTSAVYYYFGQWRDDGTTETIHDLLRWLVREHHRRKA
                     DPSAVVLDSQTVRSSTNAPKGTTGLDPGKKSPGRKRGIAVDTLGLLIAVVVVAASVHDN
                     TIGTALLDRVAAAAPPVRKAWVDAGFKTTVVEHGAGLGIDVEVVGREPGARGFTPLPKR
                     WRVEQTLGTLMLHRRLARDYEAKPASAVAMIHWSMVEVMARRLTGAATPTWRDPPV"
     misc_feature    20276..20288
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    complement(20521..20532)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    complement(20528..20542)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.9"
                     /tool="antismash"
     misc_feature    20696..20709
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.62"
                     /tool="antismash"
     gene            complement(21045..21869)
                     /locus_tag="FRANCCI3_RS10255"
                     /old_locus_tag="Francci3_2038"
     CDS             complement(21045..21869)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436468.1"
                     /locus_tag="FRANCCI3_RS10255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2038"
                     /product="DUF3050 domain-containing protein"
                     /protein_id="WP_011436468.1"
                     /transl_table=11
                     /translation="MSRYNWDLIDPRIEEIRRKIDKERSGIIDHPIYSCMRTLDDVQVF
                     MESHVFAVWDFMSLLKSLQAELTCVDIPWVPRGRAAGRRLINDIVLVEESDELLGGFTS
                     HFELYLGAMEEAGADTSRIKEFLQLISDGTEVPAALVAAEAPAPAAGFVRWTWDLVTNA
                     PAHSQAAAFAFGREDLIPDMFDHVIRANADEPRLRTFRDYLVRHIQVDGEEHTPMAMQM
                     LVDLCGQDDRLWAECTRTTMDALRARNQLWTGIALAVEGSRLCPGDEPVPAG"
     misc_feature    22534..22546
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    22547..22556
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.81"
                     /tool="antismash"
     misc_feature    complement(22549..22562)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.5"
                     /tool="antismash"
     gene            23039..23530
                     /locus_tag="FRANCCI3_RS10265"
                     /old_locus_tag="Francci3_2040"
     CDS             23039..23530
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436470.1"
                     /locus_tag="FRANCCI3_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_2040"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_236701542.1"
                     /transl_table=11
                     /translation="MFSTKDVNKIKARMDLRATAGDGLRALSALESYINASDISRGVLD
                     LVRLRVSQINGCAFCVDLHAYDLKQAGESDERIWALAAWRDAPYYSEAERAALALAETA
                     TRLHDNPNGVMEPVWDLAAMYYPEGQLAVLVLAIASINAWNRINVANRQVAGAARHAGP
                     "
     misc_feature    23056..23071
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     gene            complement(23719..23979)
                     /locus_tag="FRANCCI3_RS10270"
                     /old_locus_tag="Francci3_2041"
     CDS             complement(23719..23979)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRANCCI3_RS10270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Francci3_2041"
                     /product="hypothetical protein"
                     /protein_id="WP_011436471.1"
                     /transl_table=11
                     /translation="MTANYIIIGRAGAVPLADLCERIASVNGVREQYQTAEAGEVLLLA
                     RTLTDEPGEIERLVEALVTQGLGVGMIKRIDRFFRASELFV"
     misc_feature    24588..24603
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.49"
                     /tool="antismash"
     misc_feature    complement(24703..24718)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.48"
                     /tool="antismash"
ORIGIN
        1 gtcgaggccg cctggcagcg cggctggcag ccggctgacg tgcaccggat cgtgaaccgt
       61 caggcaggcc agcgccaggc gcgactcgcc gtcgacgcca tcgccggcca gatgcggcaa
      121 tacgcggccg ccaccgtcga cgagcggtgg aagaaccagc tgtatgatct taacgccgtt
      181 ctgtggtggg aggatgacgg cacctggctg gacgcctggg gtgaccggga gggccgggac
      241 cgggcggagg cgcttgccga cacccttggt ctgctcaccc ttctgcacac ccttcccgcg
      301 atcgaatccc tgtgcccccc gccaggcacc acacgacgcg acccaccagg tcgccccgcg
      361 ggacgcggcc acggccaggc ggacccgggc caccgggccg gggccggccg gagcgccgac
      421 ccacgcatcc tcgacaaggt ccgggcgctg ctggcgaagg ccgaatcaac cgggttcgcg
      481 gacgaggctg aggcgctgac cgccaaggca cagcagctca tggcccggca cagcatcgac
      541 gaggcgctgc tcgcggcgcg ggagggaacc cgcgacgagc cggccggccg ccgggtcggc
      601 gtcgacagcc cttacgaggc ggccaaggcc agcctgctcg acgtggtcgc cggtgcaaac
      661 cgatgccgtt cggtgtggac aaagaacctc gggttcgcca cggtgatcgg tttccagcct
      721 gacctcgacg ccgtcgaact gctgtacacc tcgctcctgg tccaggcgac cgcggcgatg
      781 atgcaggccg ggtcccgcca cgggcggtcc cgcacccggt cgttccgcca gtcgttcctc
      841 gcctcgttcg cggtccggat cggccaacgc ctgacggccg ctaccgagca ggccagtgaa
      901 caggccgcgg tcgaggcggg cgagagccgg ctgctgcctg tgctcgccgc ccgtggcgac
      961 gccgtgaagg aggcagccga gacgatgttc ccgcaggtcg tcgcccgggc ggtgaacgcg
     1021 accgacggcg aggggtgggc gtccggccgg gccgccgctg acctcgcctc cctgcacacc
     1081 tacggcgagg tgaccaccgc ccggtcccga tagccatggc gccggagccg gccctcgcct
     1141 caccggtcac gcgatcatcc tgttcggggc gggacaggcc cgcgtgcggg cgcacctcgc
     1201 gcatccgctg ggagtgaagg gcttcgccgt ctcatgtggg gggtgggagt ttcttccggc
     1261 aggtgatcgt ggcggccaga gtgaggaacc cgaggaagtt ccggccatcg cgttcgtagc
     1321 ggatggtcaa ccggcggtag ccatccagcc aggagatcgt tctctcgcct ttccaccgat
     1381 gccggccgag acgttcggtg ctgtccaccg tcgtgttcac actgcccgcc ggagacgcac
     1441 ccacctggct ggacgcgcgt cagggctgtt cgccgcgcgc tggatcatcg acatacccgg
     1501 ggggagctca ctcgtcgagt tcgtaatcga accaaatgtg gtgggtgtcg tcggagtcga
     1561 tctccatgcc gccggtgccg cggatgccgg taagagcgtg tctcgcgtgg ccgctccggg
     1621 tacatatcga tcatggatgt gttggggagc agcctcgccg ggcggctggt cccggacgag
     1681 ttgtgggagc tggtggaacc gctgctgccc cggttcgagg cccgctggca gggcggtggg
     1741 actgccccga tcgaggatcg ggcggtgttt accgcggtgg tctacgtgct gacctcgggg
     1801 tgtgcttggc ggcatctgcc gtccgagttc ggggtgtcgg tacccacggc gcaccgtcgg
     1861 ttccaggcgt ggacccgggc gggtgtctgg cctcgaccgc accgcaagat cttggatctg
     1921 cacggtgtgg ccggacgggt cgactggtca tcggcgatcg tggacgcggc cagcctgcga
     1981 gcgaaaaagg gggaagcctg accggtccga acccggtcga ccgcggcaaa ccgggctcga
     2041 agatccatgt cctgaccgac gcgggcgggc tgccgctggt cgtggcggtc tccccggcga
     2101 acccgcacga cagcggggcc ttcgtcccgc tggtggccag catcccggcg atccgttccc
     2161 gccgtggacc gcggcggcgc cacccggcca agctgcgtgc ggacaaggcc tacgatcagc
     2221 cggaacgacg gcgtttcctg cgccggcgcg gtatcgcggt gcggatcgcc cgccgtggtg
     2281 tggacagtac cgaacgcctc ggccggcacc ggtggaaagt cgagagaacc ctggcctggc
     2341 tcggtggcta ccgccgtctc accatccgct acgaacgcaa cggctacaac ttcctcgggt
     2401 tcctctgcct ggctgccgcg atcacctgct ggaagaagct cccgcactcg acgtgagaca
     2461 cgctctaagc cgggcggcta agcgtcggac aggcgccgca gcacattgcg gtccgtatgg
     2521 gcgaccgggt cggacacccg ctcgtgatcg atggtggtcg tggaggtgta ggcgaagctc
     2581 ccgttgccgg tgacggtgat gctcacctcg tagcggatac tgttcgcagc gcgcgccagg
     2641 taggggttgg acaggatgcc gtacgtgggg gagccggcct gcgcccgcag ggtgaagtcg
     2701 gtcgcgtccg gcgccacggc accaccggcg atcaggaccg caccgcgggg caccatgaag
     2761 caccgcatga cgtggccgag attggcgtcc cacagccagt agccgatctc agtgtggaac
     2821 gccttctcct cgccagcccg ccacgcggcc atgtggtagt cgaggccgta gagacactgc
     2881 gggccgttgt ccacgggacc gaagggcttg aaggtgaccc tctcgcggta cggggtctcg
     2941 ataatcgtgc cctcggcgtt gccgaaggca acgtccaccc cctggtcgcc ctcccacgca
     3001 ccggccaggg ccgccaacgg accgaactcc gggccgactt ttcccgcctt ctccgtcttc
     3061 cctggctttc ctgtcgtttt cgtcaccgca aatcctcctt gaacgaggaa ccacctacag
     3121 gtggcacaat tccggaacat gcccggaaca tctcgacatt actgtcaaat tcctgcaagc
     3181 cgctgttgcg cgactctcaa gccgcgccgg acggcacatt caccgtgctc acgggctcgc
     3241 cctcaagatc gaacatttcg ccggtctgtg ggcacggcgc tttggtgggt acggcgccgc
     3301 ttcagtctta cgtggtggtg tggcgggggt gggcggcttc gtgttcgtag gtctgccagc
     3361 gcccgaggat gtcgcgttgg gcgagtgccg cgagctcgtc ggcttcgtcg gggttgacgg
     3421 tgttgaggag ggtgaaccgg gattcggtgg cggcgaactc gctgaagggg atggacggtg
     3481 cccgcgagtc gagggagaac ggcctttccg cgcgggggtc gacccggtag agcggccagt
     3541 atcccgattt caccgcggct ttctggtggg ccaggccgtc ggtcatggtg atgccgtggg
     3601 cgatgcagtg gctgtaggcg acaatgaggg acgggccgtg ccagctggcc gcctcgttga
     3661 aggctttcac cgtgtgctgg tcgttggcgc cgagggcgac ctgcgcgacg tacacgtcgc
     3721 cgtaggcggc ggcgagcagc ccgaggtctt tcttgcgggt ccgtttgccg ccgccggcga
     3781 acttcgcgac cgcggcgcgc ggcgtcgact tcgacgcctg cccaccggtg ttggagtaca
     3841 cctcggtatc gaggacgagc acgttgacat cgcgtcccga cgcgagcacg tggtcgaggc
     3901 cgccgaagcc gatgtcgtac gcccacccgt ccccaccgat gatccacacg cttttgtcga
     3961 cgaggtcgtc gaggacagcg tcgagggtgg tgtcgtggtc gacggtggcc agccgccggc
     4021 gtagttcggc cacccgctgg cgttggtcga ggatgccggc ctcggtcgac tggtcggcgg
     4081 tgagcagcgc ctcgacgagc gtgccgccga ccgtcgcggt ctgtgcgcgc agcagtcggc
     4141 gggcctcgcg ggcccggctg tcgagcgcga ggcgtatccc gagcccgaac tcggcgttgt
     4201 cctcgaacag cgagttcgcc caggccgggc cgcggccgtc ggtgcccgcc gaccagggtg
     4261 tggtcggcag gttgccgccg tagatggacg agcatcccgt ggcgttggcg acgatgatgc
     4321 ggtcaccgaa cagctgcgtg agcagtttga ggtagggcga ctccccgcag ccggcgcagg
     4381 cgccggagaa ctcgaacagc ggctcccgta gctgcgagcc gcggaccgtg tccggtgggg
     4441 cgagcgccgg tgggaccgcc ggcagcgttt cgcggaacgc ccatccggca cgttcctcct
     4501 cgaagcgggg tgcggcgtcg accatgtcca gggcgcgatg gccctcgatc tcccggctct
     4561 tcgccgggca ggcctcgacg cagatgccgc agccggtgca gtcgtccggt gccacctgca
     4621 ccgcgagccg gaacgccgcg agggtgcggt ccttcggctt tttgtgccgg aacgacgccg
     4681 gcgcgtcggc gagccgcgcc gggtcgaaca acgtcatccg gatggcggcg tgcgggcagg
     4741 aaatcgcgca cttgccgcag tcgatgcaca ggtccgcatc ccacaccgga agctcgcggg
     4801 tcaggccgcg tttctcgtac cgggccgtcc cgacggggaa ggtgccgtca gccggtagtg
     4861 cgctgacggg aagcaggttc ccctcccctg ccatgatccg cgccgtcacc tgccggacga
     4921 atgcgggcgc ctcgccgagc agctgccggc gcgcctggcc cgtgaccaca cgagcctgca
     4981 ggtcgacctc gtgcagggcg tcgagcgcgg catcgatggc ggcgaagtta cgctgcagca
     5041 cggcgtcacc gcgtttgccg cgggcggcgc ggaccccgtc cttgaccgcc gcgatcgcct
     5101 cgtcgcggtc cagcagaccg gacagcgcca ggaaacaggt ctgcagcacc gggcttacga
     5161 tcccgggcat gccggcctgc ttcgccaccc ggtcggcgtc gacgacgaac aggcgcgcat
     5221 cccggtcgag caggtgccgc tgcgcgtcgg ccggcagatg ctcccacacc ttctccggcg
     5281 catgcgggct gttgagcagc acggtggcac ccggcgcggc cacggcgagc acgtccaccc
     5341 gttccagcag cgaggactga tgacagccca cgtactgggc gttctggata agccacgggg
     5401 agtcgaccgg tcgtggcgac agccgcagat gcgagaccgt catcgacccc gacttcttgg
     5461 agtcgaacac gaagtacgcc tgcgcgtgca gcggcgtgcg agctgcgacg ataccggccg
     5521 ttgcccgcgt ggcacccacc gtgccgtcgc taccgagccc gtagaacacc gcccgcagca
     5581 cgtcatccgg ctccgggaca cggtcgtcgt ccacctcgag cgacaggtcc gtgacgtcgt
     5641 cgcggatacc caccgtcacc tcccggcgcg gcgccgcgcc ggccagctcg tcgaacaccg
     5701 ccgccgccat cgccggggtg aactccttcg acgccaaccc gtaacggaca ccgatcaccc
     5761 gcggcatccg ctcgggccgt tccgcgaacg cggcgacgac atccagccgc aacggctcac
     5821 ccgacgcgcc cggctccttc gtccggtcca ggaccgcgac cgaccgcacc gtcgagggca
     5881 ggcacgcgag caacgcccgg ccgtcgaagg gacggaacaa acgaacctgg acgaacccga
     5941 cccgctcgcc tcgctcgacc agccgggtga ccgcctcccg caccgccgac cgacccgacc
     6001 ccatgacgac cacaacccgc tcggcctcgg gatgaccctg atactcaaac agacggtagg
     6061 cccggcccgt cgccgcggcc agccggtcca tcaccccctg cacaatcccg ggaaccgcgg
     6121 cgtagaacgt gttcgacgcc tcccgggcct ggaagaacgt gtcgggatcc tgggtggtgc
     6181 cccggatcac cggacggtcg ggggacaacg cccggcggcg atgggcatcg atatgcccgg
     6241 cagccagcag accacccagc gtgccgtcgt cgagcaacgc cacctcgttc agctcgtgcg
     6301 acgtgcggaa accgtcgaag aagtgcagga acggtacccg cgactcgagc gttgccgcat
     6361 gcgccaccgc ggccaggtca tgcgcctcct gcggcgacgc cgaacacagc atggcgaaac
     6421 cggtcgacct cgccgccatc acatcactgt gatcaccaaa gatcgacagt gcgtgcgtgg
     6481 ccacggtccg ggccgcgacg tgaagaacca tcggcgtgag ctcgccggcg atcttgaaca
     6541 tgttgggcag catcagcagg agaccctgcg aggcggtgaa cgtcgtcgac agcgcacccg
     6601 cctgcaacgc cccgtgcaca gtgccggcgg caccaccctc actctgcagc tggacgacct
     6661 cgggcaccgc accccacagg ttcgggcggc ccttcgccgc ccacgcatcg gccagctccc
     6721 ccatagccga cgccggggtg atcggataga tcgcgatcac ctcgctcgcc aggtaggcca
     6781 ccaacgcggc ggcctcgttc ccatcgatcg tcttctgacc catacatccc agactcaggc
     6841 gtccggaggc ggatcgagga gggacttcct tcccgtcccc gaaggcggaa gtcaccagta
     6901 tccgactccc gacgacgtta ccgatccaga aacagccgta gtctgctggt gaaccggacg
     6961 cggaagcatt gcgggtccgg ccgaggagac acgacgtccc tccgccgccg ggcggagcgc
     7021 gcgaccggga gcgaggatgc ggtgaaggcc gtggcgatcg ccagctacaa gggcggggta
     7081 ggcaagacca cgctcaccgc aaacatcggc gccgcgatcg cccggctggg gagacgggta
     7141 ctgatgatcg acctggaccc gcaggcgaac ctgaccttct ccttttaccg acccgagacc
     7201 tggcggacgg acctcgccga ccaccggaga accgtcaagg cgtggttcga gtcgtggcgg
     7261 ccggagacca ccccaccgcc cctcgcgggg tacgtgacca caccatcggt cgtcaacgcc
     7321 gccgtcgccg cgggcggcgg cacgttggac ctgctcgcgt cgcacctctc actcggcgac
     7381 atcgagatgg acctcaccgc caggctgggc ggggcgcggg cccaccggtc caccaggtac
     7441 tacttcgacg tctaccagcg gctggccacc gggctggcgt ccttctccac gtacgactac
     7501 gaccttgtgc tcatcgactg cccgccgaac ttcggagtca tcacccgggc cgcgatcgca
     7561 gcctgcgacc acctgctcat cccggcccgg ccggacaacc tgtcgacgct gggcatcgaa
     7621 catctgatga gcagactggg ccggttcgtc tgggagtaca acagggtcgc ggggttgcag
     7681 tccgggatgc atccggccgt gaaacgactc gaaccgcggg tgctcggtgt tgttctcatg
     7741 atggtccagt actacggcgg tcggccgacc agcttcctgc ggccctacat ccaccaggca
     7801 tctggtctcg gactcccggt gttcgagtcg atgctccgcg tgagtaaccg gagcttcgct
     7861 ggagcggctg gaacccaact gccggcggtg ctgtccgcgg atctcccgcc cgaggtggcc
     7921 cgggagctga tcagcctggt cgaggagttc ctccgacggg tcggggcggc cagccgcatg
     7981 gcgggcccgt cgcataggcc cgtcgcgtag gcgaggccca gaggccccgg cgtccggcca
     8041 gtcatgatcg acatcccccg gggtgcacct caagtaatga tcatactgct tctcgttctc
     8101 gtcgaagcgg gccagaactc gcaagtcggg acttgatcgt ctgatggtcg ggggtagcga
     8161 caagcacccc cttggagcgt gtagcatcgc agtcgttcgc gggtgagaca tccgcgaacc
     8221 acctgtccgg gtggcggaat ggcagacgcg ctagcttgag gtgctagtgc cctttaacgg
     8281 gcgtgggggt tcaagtcccc cctcggacac tctcgttcgt acatgatccc ttgaggcttg
     8341 gcctcggcga tcactcggtg ggctcctggt tcgtaggtga gttgcaggcc gagttgggtg
     8401 tagatctcgg ctttatcggc cgggtcggct tcggtgagaa cggcgacgat gtcgcccacg
     8461 gcggtgacca tgtcgtggat ctcctgttcg gtcatggggg ctgcgccgtc cgggtcgagg
     8521 ccggcgcggg cggcgtgggc gttgatgtgg ttcgcggcct gcgtctgggt ccagccgcgg
     8581 gcgtggcgat gggcggcgcg ggggcggtag tggtagcggc gggcgaactc gatcgcgatc
     8641 tcgtcgtgac tcatcccgac cgcgcgcatc cgcgcccgca actcgtcctg ctctacccgc
     8701 tggcttggct tggccgtcac gacgggctag atcccctcgg aaatccggtg gtcgatcttc
     8761 cggtggttcc tgactggaac cattctcacg gtagtccttc tgtcacggac cgagcggtac
     8821 gggatgacgt cggtcctcgg ccgacctgtt gttcagcttg tcgctgttgt gcactcgcag
     8881 tgcctggcgt ggcgtccgag acatccacgt agctgatctt cggcgaactt caccgtctcc
     8941 atcaaatcgc cgtacagcga ttccgggatg cttccggcat cgagcccggc ggcgcggaag
     9001 acatcggcca gggtttggcg ctgcgtcgtc gtcatcgact cccggaggcg gtgcgcgagc
     9061 gtgtcgcggg ccgtgtacgc gtccttgaac gtacctgcga tcagcgcccg gcgtagtacg
     9121 tcgatgcgcg gatggtcgtg gccgtcggcg aggtcgagcg cgatcatgcc tgctcgggca
     9181 cggaagacca tggtcgagag gtcgggctgc cgcatcaggg tgagcgcggt ggcgaggagc
     9241 ggggcgatct gcgggccggt gtcggcgcca gcctgtcgca gacagtgcac ccgcaggatt
     9301 gtttggatcg cctgttccca cggttcgggg gtggcgctct ggtcgaccag cgctgctgcc
     9361 tgctcggtgt gcccggcctg ggcgagtgcc aggacggtcg cctgtcggcc gtcgagcagt
     9421 cggcggccga ctccgcggtg ggccgcggct tgttcggcgg cttcgtgcca gcgcccggcc
     9481 cgtgccagtg cccggactcc gtccgccagg agcgccgtcc aggtcagggt gcgcatggtc
     9541 cgatggtcgt cggaggcgca ggtgacgttg tggagactga cggaccgtcc gtcgatcagt
     9601 gcgctggtct gcgtgcgcgc ggcctcgtgc agggcctgga ggatcgcgtg agcgcggttg
     9661 ccgtcaccat cgcggatcag ttggcgcggg aggttgagca ccggttggag ggcgagttcg
     9721 gcggctgagg cgggcagggg ccgcgcctga tcgaacagcg tgtgttggcg ccagcacagg
     9781 tcttgggcga ggtctggttg tccgcagtcg gaggcgatca gcgccgcctt gttgcagact
     9841 tcggccgctc ggaggagcgg gagaccgtcc gatgtccgtg cggccaggtc gtgcagctgt
     9901 ctgactcggt cttcgagggg gaggccgggt ggtcgggggc gttggaccag cgggaaccag
     9961 gcgagcaggt tctcgtcggc cgggtctgtt ccgacgttcg tcatgccggt tcccgatcgt
    10021 gcggctggtg atcggaggcg gggtcgtgcc cgaacacgac ggtcttggcg gtgtgcgcga
    10081 ggacggcttg cgccgtgtgg ggaaggccgt gccggttcca ggcgaagatg atgtggtggg
    10141 cgaggacggc gcgtaggccg cggcgtagcc ggccgtcggt ggccagggcg gccagttcgg
    10201 tgccggcggc ggcgaagtcg ctggtccaat cggtgaaggc cggcggcagg gtgtccttgg
    10261 ccaggctgtc ggtgtcgatg ctcatcaggc gccgcaggcc gtcacgcagg gtgcggagcc
    10321 tgtcgtcggg ggtgcgctca ggtggttgcc ggtgctcggc gactcgcgcc cacacgtctc
    10381 cttcctcgta ccagtcgagc ccggcggcgc gtagcaggtg cgagcacagc aggaccgaca
    10441 gttcacggcg gcgccggtcg gccggtttgt ggctggtgct gttcaggtag gtgagcaggt
    10501 gtcggctgtc gaggtggaag agccggtggg cggtgtccat gccttcggcg ccgccgaagg
    10561 catggctttc tggttcgtag agggtggacg tggcgtcctc gatgcggcgt gtctcccgga
    10621 gatcggcgag acgggtgtgg atgtacgcct tggcctctcc tgtcgtctgg cggggcaggt
    10681 agcggatgcg ccagcagggc gccttgcgta cgaagaacca ggaggtgatg agcccgtcgg
    10741 tctcggcggt gtccagcaga ggggcgaggt ggtccacggc ggtgccctcg gcgttcgccc
    10801 agtcggggaa ggtgacgttg acctggtgcc aggtgcgggt gtccatgtcg gctcctgatc
    10861 aggccagcag gaggaaggcg tcccagcccg acgtcggggc ggcgccggtg ccggcggtgt
    10921 gcagggcgag ggcggcgccg gcggcgccgt cgagaagttc ggggtcgcgc acggttgtgc
    10981 ccatctgtgc gatcagcctg gctgacaggc cggggagttc ggcggtgagc tggggatggt
    11041 gggagtcggc cgccatgcgc caggcggact ggagtagccc ggcggtgccg tgacacaggc
    11101 cgatctcggt gagctggtcg agttgcgcct catcgcgaag tgccgcgagg agcgcgttct
    11161 cggcggcttg ctggcgtgcg gtgtcgcgca gggccatgcc ggcgagctgt tgggcgcggg
    11221 cggtgccgct gacgccgtaa caccaggagg ggcggggccg cagggttgcg gcgaccttgc
    11281 cttcacggac ctggcggagg gtgatgaatc cgggccacca ggggccggtg tcgccgtgct
    11341 ggcaccagcg gtcggtccag gcgcagatcc gtgcgatcgc gtcgtcggcg ccacggaccg
    11401 gcaggccgcg caggtgggcc agggcaagca gggcgaggac ggcgctgatg ccgtgcgcga
    11461 ggccgacgtt gccgtgtcct tgggggaatt cggggctggg ttcgccgttg ggtgcagagt
    11521 ccgtccacca gggtgggagg tcgtctcttc cggccagtgg ttcggtcagt ctgaccaggt
    11581 acgacagcag ttcgccggtg atcgggtgat cggggtggcg gcgcaggtgg tagacgccga
    11641 gtccggtcag gccccggatc aggtcgaact ccttcatcgc gggccgccgg ctctgttcga
    11701 tgcgtgtgtg ggccgcggcg agtcgggtgc gggtcatggc gacgacggcc tgatccagat
    11761 gggcgagggc acggtggtac cggcctgatg gtccggctgc ggtgtgcagg gtgaaggcca
    11821 gggccggagc gcccaggtac aggcccgcgt tggccgccgc ggtcagggcg tcggacgcgg
    11881 cggcggacag ccaggcgtgc acggtgctcc agtcgccgta cccggagcgg gcacgttcga
    11941 tgtgcagcag ggcgatgccc gccgcgccgc cggcgagcga ctgcggccac gcccttcccc
    12001 cggtcggtcg gtgggcggcc caggcggtgt gcgggtcggc tagtgcttcg gcaacagtgt
    12061 tcgcggcggc gagcgcgtcc ggatcggagc tggtcatgat gggttcctcg tgcgcgcggt
    12121 ccagctcagt gcggcggcgc gagccaggtg caggcaggcg cgttccccgg ccaggctgac
    12181 tccggccatg cggacatggt ggagatgcag aagatcaggc agcagggagg tgggggcctc
    12241 cgcgcgggtt tcctggagga cgtgtcggta ggcggtgagt gcctcgcgcc ggtgcgccca
    12301 gcaggagagg acgtgctcgc ctccgggctg tgcggccagc gcgcgtgggt cggccgggtt
    12361 cgccagggcg acggtctgct ggtacagcgc gcgggctggg gcggacggct ccgtccgggt
    12421 gtggctgatg agccagctcg tcgcctcggc ggtgtcgccg atcaggccgg tcacgatggc
    12481 gagcatgctg gcggcggtca gcgcgcgacg gtcgggcccg ctcttctccc tggaggcggc
    12541 gagctgggcg agggccgccg ctgagtcggc ggcgaagtac gcctccgcgg cgtccatcgc
    12601 ggcggtgccc ccgaagcgtg aggtctcggg gaagtaggtg tcccactgcg cgcgggagat
    12661 caggccggcg cggcggagcc gctgggtcca ggcaccgatc cggtcggcgg tcggcgccac
    12721 accgtcggcg gtgaccgcga gccgcaggcg cagatggtcg tcggggtcgt ggtagcgcag
    12781 gaaccaccag cgcgcctcgc ccgcggcctg ctgcccgttc agctcgtgga cgaggtgcgg
    12841 cagatggcgg gtgaggatgt cgtcctggca accgaggccg gcgtagatct tgactgagaa
    12901 ccgtgcgtcg cagcccggaa gatgcccatg atcgcggcca acgacctgcg cccggctgaa
    12961 ccagcccggt gtcgccgccg gcgcggcgac cgctgccagg gggacgacga tctcgtgggc
    13021 atgcccgctg acccagccgg ccgcgtcggt gtcgggggcg gcgcgcagca gcgcggcgcc
    13081 ggagcggtcg aggtgggagc gcagcagtac ccggtgggcc ggctcagaca ggtccagtcc
    13141 gatgcgctgg tcaccgtcgc cgaggtagac cgccgagggg aggttgacct gctcccgcca
    13201 gctggccagg gcacggtccc actccgtcca gccggccgcg gagccgggca ggtccgcggt
    13261 ccccagcagc cagcgcgctg gtgagaggac tgttcgtcca tgccgcagcg ccggcaggaa
    13321 cggtagctgg gccgcgaccc cccagtcgaa gggggcgcag ggaacgctca gcgcggccgg
    13381 cgcctcggcg aggaaacgcg ccagcggatg cgcgcgtcgc accggctcca ccgcgttgag
    13441 cgccaccggt tccaccagtt ggcggcggga gagcgagagc agatagatcc ggtgcacatc
    13501 ggccgtcacc acgatgtcgt ccagaggcag cgagtccccg tcctcgctgt cgtcgtactc
    13561 gccgagggag agccggtgcg ccatgatctg gggggcgcgt cccaccgtgt cggtgttcgt
    13621 gtagcgagcg ggcgcggaga tctgcacgct cagcgcgtcg cggctcgcgg tgggaagacc
    13681 cgcgtacagc gcgcgcatcc gcgcactgtc cttcgcgtcg aagaggtcga ggagtcgtcc
    13741 ggtcgtggtg ccggctctgc gtgacacccc gacgaccgcg agggtgaacg cgccatcgtc
    13801 gagcgagcgg gtgctcgtgg cgtggacgcg cagggtgagt tccgtggtgg gctgaacgtg
    13861 ggcgtcctgg tcgacgaccg taaggtcgct gatcatcctg tcgtcgagga cgatctcccg
    13921 ttcgcggcgc agcgcggcgt tctgcgccaa cgccaacagc ttcgcgtccc gatcggtgaa
    13981 cgtcacgccc gcgggtgcgg gactgccggc gtagccggcg ggataaccca gtccgatctc
    14041 ggggtcgacc gcgtcgaaaa cgggaaccag agcgcacggc ccgtaccgtt cgaggaaccg
    14101 gccatgccag gcgtcccagc cggagctgag cgtcgagcgc cgcgccaggc gcaccagcac
    14161 gcccgccgcc gctgcggcct cgaccgcgac cgcgcggggc acagccagcg cccagtccat
    14221 ccgcagatca acccggagtg ccggctccgc cgaagggtgg acctcagcca tgtcctcgcc
    14281 gaggcgctcg cggctgctgc gcgcgacggt ccaactcgac gcgctgtcgt ggctccgcag
    14341 cccatcgaca atcccgttca ggcgttcggc gacccaggcc gcctcgacgg tgaccggccc
    14401 gccatttagg gtcgtctgga gcacacccac gacatgacgg agaggatcgc tcgccgtcat
    14461 cggaggccgc aggttcgtga gcaggaaccg ctgcgccacc agatcggcca gaagtctgtc
    14521 gacgacgtcg gcagggaccg gagcgaactc ggacgcgagc ctggccgcga ggtcggagaa
    14581 ccgcaccgag cggcggccga tacccatcgc ggcgcggacc ggtgcgtgcg cccgcacctg
    14641 cacgcgcgta ggaacaccgt cggtgcctcc tgcggcacgg tgctccagca ccagatggcc
    14701 gtcccgctcg aacacgaggt tgttcgccac cacatccagc cgcgctcgga cgaccggatc
    14761 ggcttccaac cggtcgacca ccgcgcagag ccagccagcc tcgacccgcg cgacggcacg
    14821 gtgcgccacg cctgcgcgca ccgaggcgtg gtcagcgaca cgcaccggcg cgacccccgc
    14881 gaacaggccg aacggtgtcg cccgtcccga cgcgcgaagc cggtaacgca tcaccgacag
    14941 cactgcccgc cgcaccccgg cctggggcac ttggcgtccg tcgcggatct cccgaacgcg
    15001 gcgagcgagc acagggctgg cctgctccag cgccatctcg aaggcgcgat tctgcatcac
    15061 ctcccgtaac cagaggcgcc aggactctgg tgtggccgcc ggtccgacca ggtcgggcca
    15121 tcgctcggcc acgtccacgg gcgggttcac cgcggcacgc accaccaggg agtcgagatg
    15181 ctgatacacc agccgctccg tagtcgggcg gcgtccgtcc ggccgccgag gccggccgta
    15241 cggacgccgc gttctcaggt cgtcggggcg ctggttacgg gcaggtggtc gagcaggccg
    15301 tctcgcacgt cgtgccgcag ccgtcgtcgg tcatccggat gagccggtca gcggccggtc
    15361 cggactcgac gatcgagatg tccaggtccc atgtggtgaa gtcctcctcc tggtctcgtc
    15421 ccgcctgcgg gggcacggcc aacaccgggt catcgagctg gatggacatg aagacctcct
    15481 gggttgtgat ggtggtggtg cattccggct cccgagcatc cgttcgggag cgcggaaact
    15541 cagggccagc ggacagcgac agcgccgtgc cgtttcggca ccagccccac ggacggcgcc
    15601 ggcgtccccg cggccttcgg gacgtatcgg atgtgggcgg caccggaacg gcggtgatcg
    15661 ctggcccacc ggcggagcag ttccacgtag tgctcggcga cgcgatcggc gtcgggaccg
    15721 tgcgcgacga cgccgctctc gaatccgccg gtcttctcgt tcgggcgctt ggtgcggtag
    15781 gcgaaactgc caccgctgac cagcgtgggc acacctctgg cggccgaggg cgcgaagcgg
    15841 ccgttctgga cctgcgtctc gtccacatgc aggtgcgcga cctgggccag attcgtgacg
    15901 aggaagaact ccaactcgtc aggaagatcg aaggccgctc cggaccagcg ttccagcctc
    15961 ggcgtggcca gcgcgtcgcg cagcccctcg acgtcgaact cctgggacgg gtcgtcgacc
    16021 cgaagcacga cctcgtcggt aatagggacg agcctttcgc ggaacgtccc gatgccctgc
    16081 atcgggacga atccgcacag gcgatagctg cggctgacca gaccgacgtc accgtcctcg
    16141 tcgacccggt cgaacgcgat cgaccgggtc agccctcgta gccggagcgg cacaacgagc
    16201 ctgccgccgt tcgtgagctg ctcctgccag gctggtggga tgtcccaggc ccctgcggtc
    16261 acgataatcc ggtcgtaggg tgctttttcg ggtacgccgg cctcggcgtc ggccgccacg
    16321 acttcaacat ttcgatagcc ggccgcgtcc agacaggcgc gggcccggct cacgatctcc
    16381 tggtcgatgt cgacggacgt caccgagcct ccgtcgccga ccatctcctg gatgagggcg
    16441 gcgttgtagc cgcccgagcc aacctccagg acacgcattc ccggttcaag ttcggcctgc
    16501 tccaacatga ccgcctgaat gtgcgcggcg gacagcgagc tgagcgccgc accattccca
    16561 tcgcgtttaa tcacaagtgc tttgtttgcg gcgtagaccg cctccagcgg ttcgtcgggt
    16621 gcgaaaaggt gccgaggcac cctgcccaca gccgcagcca cctgcccagt cttgatcgcg
    16681 tcccccgtgg tgcgaagctc gtccaccatc gcggcacgca acgtggccgc actgtcggtg
    16741 gcgctcgaat cttggactga agtcattttt cgacacctta atgagacggg aaatggcagt
    16801 ctaggtcgct cctctgaccc agaatatgga agtggcgatg agctaggtga agggaatgct
    16861 ccgatgatgt gtcggcggca atgtcgagta cggccgggtg agtacgacgc gactgcgccc
    16921 ctgtccagcg ccagctcttc cagacgccga ctctcacgaa tggttcgatc gggaagatgt
    16981 accgcgccgg ggaagatgcg gctggccccg gccgcaccgg cggatctggt cggccatccg
    17041 cttcgcggcc acggccacgc tgggtccgta ggtagtgcag gtgatgtgct cgaagccggt
    17101 accggcccca tcgacccgac gcggctcccc ggtcggccag ggctggccgt cggcgaacgc
    17161 cggtcgcccc agcgctgggg gggaacggcg agacgcgcgc acgcggaccg ggcgcgaacg
    17221 cgacacaagg acatgatcat ctcgcttccc tcgggtggta cggcccgcgc accgatcaag
    17281 atcggtggat gccgcgtatg gcgccacacc acgatggctg gagcccgggg ggcaagtcat
    17341 tcccaccacg acgaagcttc tcttcggctc ccgagagaca cctgacctgc gcagacagtg
    17401 gtgtcagggt gcatctatcc ggcgcgatca tgccgattcg ttcggcaggc ccgccggcct
    17461 cggcctcgat cacctgtctg ggaccacggc gacctgaacc tgctaccgcg ttccgacggc
    17521 gtctggtccg gctccaccga cgatgcggct ccttcgcgcg acccgcggcg cctctctccc
    17581 ggctgatcct gagcggacgg ctgtcggtga cagacggcta cggactcggc cggcagcggg
    17641 aggctgcggc ctccgaagct gatcgactgc cggtgtctgc cgcgtcaggg caggcacgcg
    17701 ctgccctcgg ctgcggcggc tgggtgtgcg cttgcgcctt ggtctggcga catgtgccgg
    17761 gcggctacgg cgttgggcca ggggctccgc cgacccgcgt ccggactggc ggcaggtcgc
    17821 ctctccttcg cagtgtccgc gacatcgacg atcacacgga agcgccggcc gcacaggaaa
    17881 gtccttttga gacgattgcg ccatgcgcct gctgatcctg ggaggaacct ggttcgtcgg
    17941 ccgtgtcctg gctgaggacg cggtgggccg tggctgggcg gtcacgacgt tcaaccgggg
    18001 taggtccgga ccggatgtcg caggggtcca cccgttgcgc ggcgaccgaa ccgacgtcca
    18061 ggatcttgaa cgcctcgcgg cggcggggcc gtgggatgcc gtggtggacg tcggcggagc
    18121 ggagccccgc tcggtcggcc tggccgctca ggttctgggc gcgcaggccg gtcggtacgt
    18181 gttcgtgtcg accgtctcgg tgtatcgcga ctggcccgcg tccccggtcg acgaatcctc
    18241 acctctacat ccgggaaacc ccgatcttgt ggtggaagat cctcgctggg acgcggtgcg
    18301 gtacggcccc cacaaggccg ggtgtgaggc cgcggtccgg cggagcgttt ccccggatcg
    18361 gctgctcatg gtgcggccgg gggtggttct cggcccgtac gagtacgtcg gacggttgcc
    18421 gtggtggctt cggcggatgg cgcgcggcgg gcgggtgctg gcccccgcac ccgccgacag
    18481 gccgatccag cctgtggacg tgcgtgacct cgcgtcgttc ctgctcgacc tgatcgggcg
    18541 gtcggccagc ggcatcttca acgtcgcggc gcccaccggc cacgcgacct acggccggat
    18601 gctggacgcg tgcgctgcgg cgacgcggga cgtccgaggc gcagatgaga tcgaggttgt
    18661 ctgggcggaa cccgattggt tggtcgaaca gggggtgcgt cagtggacgg agatcccgct
    18721 gtggcgggtg cagccaggga catggcgcct ggatgcgacc cgcgcggcgg cggcgggcct
    18781 gcgttgccgg ccgatcgaga agacggtcct ggccacgtgg gcgtggctgg cggccggtgg
    18841 cgctccggtc cggcatgaac gtcaggacga gcacggtttc gaccccgaca gagagcgccg
    18901 cctcgtcgac ctgtgggagt gccggtcaca ggccgcctcc ggcgagaagg gcctggtgtg
    18961 agtgggcgtt ctgcacgctt tcgtcgggcc tcagcttgag ttgatctctg gggtggccgg
    19021 tgggtcgggc tggggcagga cgaacaggcc gggatcgggc tcggtgagaa caccccgctc
    19081 taccagccgt ttcagccggg cccgcatgct ctcgacatgc cggggctcgg tgccgccacc
    19141 cagcgcccgg cacacgtcct tggcgtgcag cccgttcccg ccccgggtga acacggccag
    19201 cacctcccga taccccggcg gcagcggctc ggccggtgcg gcgtcgttct cggcggccag
    19261 gtccagcacc gtctcccggg tgatctccaa ccgttccagg gcacgttcag cggcggcgag
    19321 ctgcccggtg agccgggcga tctcctcccg cagcttttcg acggcccgcc cggcgcgggc
    19381 ccgccgagcc tcgatctgtt ccagcacctc ccgcaccggc actccgctcg tcattcccga
    19441 cactcccgcc ggtcagaccg gcgggtcacg ccaggtcggg gtggccgccc cggtcagccg
    19501 gcgggccatc acctccacca tcgaccagtg gatcatcgct accgcgctgg ccggtttcgc
    19561 ctcgtagtcc cgggccagcc gccggtgcag catcaacgtg cccagggtct gctcaacccg
    19621 ccaccgcttc gggagcgggg tgaacccccg cgctcccggc tcgcgtccga cgacctcgac
    19681 atcgatgccc agaccggcgc cgtgctcgac gacggtggtc ttgaacccgg cgtccaccca
    19741 cgccttgcgc accggcgggg cggcggcggc gacccggtcc agcagggcgg tgccgatggt
    19801 gttgtcgtgc acgctggccg cgaccacgac cacggcgatg agcagtccca acgtgtcgac
    19861 ggcgatcccg cgtttacggc ccgggctttt ctttcccggg tccaggccgg tcgtgccctt
    19921 cggggcgttg gtggaggacc ggacggtctg ggagtccagc acgaccgcgc tcgggtcggc
    19981 tttcctgcgg tggtgctcac ggaccagcca gcgcagcagg tcgtggatcg tctcggtggt
    20041 gccgtcgtcg cgccactggc cgaagtagta gtacaccgcg gacgtcgggg gcaggtcgtg
    20101 gggcaggtag cgccactggc agccggtccg ggcctggtag aggaccgcgt tcacgatctc
    20161 ccgcatgtcg tagccaccct cgtgcccgct agccgaggga tgccgggcct tccacgcggt
    20221 gaggaccggg cggatcaggt cccacgcctc atcggacagg tcactggggt acggcttgcg
    20281 ttctgccatg tcttccagca gaacgcgcca gccggcgaac gcaagacgat caactccgca
    20341 ccccagagat caactcaagc tgagacccgg cgaaagcgtg cagaacgccc actgacaaca
    20401 ggatcagcgt gccggtcgac cactatccag acgggctgcc tgcggccggc agcccggtcc
    20461 ggtgcgacga cagagagggc cgccgcgcga gacctggtga cggtgcgcct ggacatggag
    20521 gcgttcgtgt ccgagacgaa cctcggacgg cccctgaagg gagcgacgac ggcccgcgcg
    20581 gagcaatggt gatccctcgc ccccggtcga ggcagggccg ggcgcgacca ggccgccagg
    20641 ccgcacctgc cggcctggtc gcgcccacgg cggcggcacg catagaccct gcgcaggaac
    20701 gagcgttccg agccaggacc agccaggccg ccgccctcta cgcctggtac gaggacgcgc
    20761 ttcgacagct acaccgccac ggaccgggcc accggtctgg ccccttcccc tgtccagaga
    20821 cggagccgga gtgcggcacg ccggctagct cggcttcccg cacgccgccc aggcgatcag
    20881 tcatccgccg gcgccgagtg cagggccgcg gacccagcag ggagacggtc tacgcgatca
    20941 tcgaccaccc atcgaaagcg ctagccccgc cgctctcgcc gcgcacgtcc gccgacgctg
    21001 ggccatcgag gtgcgacatg aagtcgcact gtctgtcagg cgggttagcc cgcgggcacg
    21061 ggctcgtcgc cgggacagag ccgagatccc tcgacggcca gggcgatgcc ggtccacagc
    21121 tggttgcggg cacgcagcgc gtccatcgtg gttcgggtgc attccgccca caaacggtcg
    21181 tcttggccgc agaggtcgac cagcatctgc atcgccatag gggtatgctc ctcgccgtcc
    21241 acctggatgt ggcggacgag gtagtcccgg aaggtgcgca gccgtggctc atcggcgttg
    21301 gcgcggatga cgtggtcgaa catgtccggg atgaggtcct cccggccgaa agcgaacgcg
    21361 gcggcctggc tgtgggccgg ggcgttggta acgagatccc aggtccagcg aacgaaaccg
    21421 gcggccggag cgggggcctc ggcggcgacc agcgcggcag gcacctcggt cccgtccgag
    21481 atcagctgaa ggaactcctt gatccgcgag gtgtcggcac cggcctcctc catcgcgcca
    21541 aggtagagct cgaagtggct ggtgaagccg ccgaggagct cgtcgctctc ctcgaccagg
    21601 acgatgtcgt tgatgagccg ccggccggcg gcccggcccc ggggaaccca cgggatatcc
    21661 acgcaggtga gctctgcctg gagcgacttg agcaacgaca tgaagtccca gacggcgaac
    21721 acatggcttt ccatgaagac ctgcacgtcg tccagcgtcc gcatgcagct gtagatggga
    21781 tggtcgatga tccccgaccg ctctttgtcg atctttcgac gaatctcctc gatcctaggg
    21841 tcgatgagat cccagttata gcgcgacatg cgtccacctt atctcggtcg gtgcccgggc
    21901 ggattgagcc ctcgcgggcc cggtccttgc cacgagtcat gagagatcgg gcggtggagc
    21961 tggaaatcgc tctcgccgac ccggtgttcc gttttccgtg atcccgtccc cgcgccgggc
    22021 gtgatggtga agattttcgt ctccgggcta gccggcccac gcgagatgcc gcgagagatt
    22081 ctcgccgccg atatctacag cgttgtgccg gcgaaccggc acggacttcc cgttcgtaac
    22141 ctggtcgctg gcgaccgtga ggcagccgac ctgcggcagg aaatctacgg catcagtggc
    22201 ccgctcgtgg tcaacacggc aatcagacct ctcctggcgt cggaggagcg catggtcgcg
    22261 cgccttggcg gagctccgtc agcgctattt cgggattcgg tacgaggaac cgaagcgcag
    22321 acctgtcgca cctgacgagc taccggaaca gtttcccttg caacttcgcg aactcattga
    22381 ggttgttccc ggagatgggg ctgtccgcga acaatggcga atgctctaac atcagcactc
    22441 gacggacttt caggaccgcc gcccggcgca actctagcac gcgaggcgac gatgtccagc
    22501 ggcgaatcga acaggcgtgg ccgacagaag ctcgtgaaac tgccactatt tttttcggaa
    22561 ctcgaacgcg tgcacccgct gacctgcggg ttctttaccg gacctgaacc ggggcgtcgg
    22621 gtgcgatcag gccggcgccc ggcgcggacg cgacggctgg ccaggtcacg gcgctgctgg
    22681 aggcctgggg tgctgtcgcc ctggcgacat ggagagagcg gcgccctgcc gcgcggatgg
    22741 tctcgggggc gggcagccac gaccggtggc gatcatccgg gaggcaggca ggaccccaca
    22801 gtgcatgcgg cccggcgtcc tcggcgggca ggtcgtgcgg ggccggggcg gcacggaggc
    22861 gggctgcgga gcggcgggga ccctggacat gtaatgtcca gggtgtacac acgggcgctg
    22921 gccggtcacg cgacagagtc cgcgcagcgt tgagcgcgct cggactgatt cgcctgtgcg
    22981 cctgcctgac gcccccgctc accggaccgg ctcgtgccgc cccatggata gttcctggat
    23041 gttttcgact aaggatgtga ataaaatcaa ggcgcgaatg gacctccgtg cgaccgctgg
    23101 cgatggtctg cgggcgttgt ccgctctgga atcctacatc aatgcgagcg atatctcccg
    23161 tggcgttctg gacctggtcc ggctgcgggt gagccagatc aacggatgcg ccttctgtgt
    23221 cgacctgcac gcctacgacc tgaagcaagc gggtgagagc gacgagcgga tctgggcgct
    23281 cgctgcctgg cgggacgccc cgtactattc cgaggcggag cgggcggcac tggcgttggc
    23341 ggagacggcg acccgactgc acgacaaccc gaacggtgtc atggagccgg tgtgggacct
    23401 tgccgccatg tattatcccg agggccagct cgcggtcctg gtactggcga tcgcttccat
    23461 caacgcgtgg aaccggatca acgtggccaa ccggcaggtg gccggcgcgg cccggcacgc
    23521 aggcccctga cctcccagcg accgacagcc tccccgaggc ggacgtcggc atgctcgacg
    23581 gtgatcggtg gcgttcgccg gcgcggctgg ccggcgtccg cgcatggtcg tgcacaggcc
    23641 gagggcaggc ggccggcgtg gccgtcaggc gaccactgag cgactgagcg ctgcccgccg
    23701 ccaccgggag acctggcttc atacgaacag ctccgaggcc cggaagaaac ggtcgatccg
    23761 cttgatcatt ccgaccccca gcccctgtgt caccaaggcc tcgacgagcc gctcgatttc
    23821 gccgggctcg tcggtcaggg ttctcgctag caggagcacc tcgcccgcct ccgcggtttg
    23881 gtactgctcc cgcacgccgt tcacggatgc gatccgttcg cacagatccg cgagcgggac
    23941 agcgccagca cgcccgatga tgatatagtt ggcggtcacc cctaactcct ttcggacggt
    24001 atgcacccgt ccagctctcg caatctctcc cgatcggtcc aagccggcgg cccgagtgcc
    24061 ccgcgctgcc ggtgcgaggt ggcggccgcg ccgggccggc gtcgctcagg agacgcccgt
    24121 ccgcccaccc cgcaccgggc cactacgcca gcagcacggg gacggaggag taactgtgcg
    24181 gattgagatg ccgaccaagc tgtggttcgc cgctcagcct gagctgcggg tacctggtga
    24241 acagaccacc gacgacggcc cggagctgga tcctggccag ggccgcgccc aggcaatagt
    24301 gaggcccgga gccgaacgcc aacgacgacc ccgcggcgcg ggttgggtct atctggttcg
    24361 gctccggaaa catcgcggga tcgcgcagcg cggcgccgag cagaagaacg acgtgggcgc
    24421 ccgccggaac ctcgtgaccc gcgacgacag tgcccgactc gagcgctctg cgcccgacga
    24481 tgtggatcgg tgccgcgagc cggatcacct cctccacgaa tggcgtggag tcgggccccc
    24541 tgagatcgcc gaaatcggtg cctctggggt cccgcaatat ttccaccacg gcgttagcga
    24601 tcaggccgat cgtagtctcg accccggcga ccacgaccgc gaccagggtg gccagcacat
    24661 cgctcgtgtc cagcccgccc gcgtcggctg aggcgagcag ccgatggact agaccgtgtt
    24721 cccatcgcgc acccagccgc gccgcaagct ccgaccgctg ttcgatgatc ctcttgaaga
    24781 acgctacgag cgtgcggctg gcctcggccg cgtgcttagc gtcgtcggcc gagtgccaca
    24841 tcagggggct gcccagcacg acgagtcgcg gcatcaggcc cggcaggaaa tccagctctc
    24901 cagggccgac tccgaggaag gtgctcagcg tgtacagctg gagcggccag gcgacgtcat
    24961 ggcacacatc aatcgcctcg ccggctttgg cggcgccggc caacgcgccg aggacctcgt
    25021 cggtggccgt ctccagaccc tcctcaagca gccgcagcgc ccggggcacg agcaggctct
    25081 gcgcgaccgt cttgacggcg cgatgatctg cgccgttcag gaagagaagc gagtcgaaga
    25141 agggcgacca tgcctcgtcg gcccagcccg gacgatgacg ggcccgcag
//
