LOCUS       NC_007777              25308 bp    DNA     circular CON 05-SEP-2024
DEFINITION  Frankia casuarinae, complete sequence.
ACCESSION   NC_007777
VERSION     NC_007777.1
KEYWORDS    RefSeq.
SOURCE      Frankia casuarinae
  ORGANISM  Frankia casuarinae
            Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
            Frankia.
REFERENCE   1  (bases 1 to 5433628)
  AUTHORS   Normand,P., Lapierre,P., Tisa,L.S., Gogarten,J.P., Alloisio,N.,
            Bagnarol,E., Bassi,C.A., Berry,A.M., Bickhart,D.M., Choisne,N.,
            Couloux,A., Cournoyer,B., Cruveiller,S., Daubin,V., Demange,N.,
            Francino,M.P., Goltsman,E., Huang,Y., Kopp,O.R., Labarre,L.,
            Lapidus,A., Lavire,C., Marechal,J., Martinez,M., Mastronunzio,J.E.,
            Mullin,B.C., Niemann,J., Pujic,P., Rawnsley,T., Rouy,Z.,
            Schenowitz,C., Sellstedt,A., Tavares,F., Tomkins,J.P., Vallenet,D.,
            Valverde,C., Wall,L.G., Wang,Y., Medigue,C. and Benson,D.R.
  TITLE     Genome characteristics of facultatively symbiotic Frankia sp.
            strains reflect host range and host plant biogeography
  JOURNAL   Genome Res 17 (1), 7-15 (2007)
   PUBMED   17151343
REFERENCE   2  (bases 1 to 5433628)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,J.C.,
            Glavina,T., Hammon,N., Israni,S., Pitluck,S., Goltsman,E.,
            Martinez,M., Schmutz,J., Larimer,F., Land,M., Kyrpides,N.,
            Lykidis,A., Francino,P., Benson,D.R., Huang,Y., Mastronunzio,J.,
            Bickhart,D., Niemann,J., Rawnsley,T., Tisa,L.S. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2006) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000013345.1-RS_2024_09_05
            Annotation Date                   :: 09/05/2024 02:41:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,755
            CDSs (total)                      :: 4,702
            Genes (coding)                    :: 4,516
            CDSs (with protein)               :: 4,516
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 53 of 186
            Pseudo Genes (incomplete)         :: 162 of 186
            Pseudo Genes (internal stop)      :: 10 of 186
            Pseudo Genes (multiple problems)  :: 37 of 186
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:46:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2146427
            Orig. end                         :: 2171735
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP000249.1.
            URL -- http://www.jgi.doe.gov
            Source DNA and bacteria available from Louis Tisa
            (lst@patia.unh.edu)
            Contact: Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-PGF
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25308
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="8"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25308
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25308
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15308](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15308
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(306..320)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.32"
                     /tool="antismash"
     misc_feature    637..655
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    665..679
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(668..685)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    1159..1174
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.42"
                     /tool="antismash"
     misc_feature    complement(1295..1311)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.65"
                     /tool="antismash"
     misc_feature    1351..1371
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.71"
                     /tool="antismash"
     gene            complement(1479..1889)
                     /locus_tag="FRANCCI3_RS09120"
                     /old_locus_tag="Francci3_1811"
     CDS             complement(1479..1889)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436247.1"
                     /locus_tag="FRANCCI3_RS09120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1811"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_237704574.1"
                     /transl_table=11
                     /translation="MLLLIRDDAVLLALRSGTGFADGWWNVPSGKLEDGEDAASALCRE
                     SREEIGLHLDPASLTLASTVHFRNERGEARLGLFFQPECWHGEPVNAEPQKCARIAWFP
                     LDEIPDSTYPYTRVGIDLHRRRENFAISGWET"
     misc_feature    complement(1908..1924)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.5"
                     /tool="antismash"
     gene            complement(1952..2566)
                     /locus_tag="FRANCCI3_RS09125"
                     /old_locus_tag="Francci3_1812"
     CDS             complement(1952..2566)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020460212.1"
                     /locus_tag="FRANCCI3_RS09125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1812"
                     /product="AAA family ATPase"
                     /protein_id="WP_011436248.1"
                     /transl_table=11
                     /translation="MLRNCLVVAVEGTHASGKTTLTHALAAHFRERGVHVACVPEPARN
                     SPFIEEIVVHGRGEFDLETEVDLFAAQLSSQLRVARQHTMIICDKTIANVLAYAWLVLP
                     GGPEGPHAPVLRAMEAFCRAWASVYDAVFYCCDKFDQHQIGDPYRSKVLDIQPAADRVV
                     RSICATVGQRIFDIPPNMSTSARVGWIAEQLTTLGLNPTSR"
     gene            complement(2566..3381)
                     /locus_tag="FRANCCI3_RS09130"
                     /old_locus_tag="Francci3_1813"
     CDS             complement(2566..3381)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436249.1"
                     /locus_tag="FRANCCI3_RS09130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1813"
                     /product="hypothetical protein"
                     /protein_id="WP_011436249.1"
                     /transl_table=11
                     /translation="MREATNLGWADTPFGAERRPFAERTPLLAAFTVLTRAASPDAMGA
                     VYLRLPRGRTLAVTERTLRFGFHAVAAEDPAETLLVAAGLDALLVQARRRAAILAGHRL
                     ADDLARLAAAGAPTRGITALAAAWPGETAQPSLARLHDTARGSTPVVLEDVCTAFHLHG
                     LFAESGTSADPARVGYGASAGAPQILRQVVLRALAIALVAARSTGHYQWDQLNLDDVVE
                     AAAWDQTTDIPAAGPTAVTPATTPPARPSSVPAVPAGRDDQTLAAEGVR"
     gene            complement(3374..4414)
                     /locus_tag="FRANCCI3_RS09135"
                     /old_locus_tag="Francci3_1814"
     CDS             complement(3374..4414)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436250.1"
                     /locus_tag="FRANCCI3_RS09135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1814"
                     /product="radical SAM protein"
                     /protein_id="WP_011436250.1"
                     /sec_met_domain="PF04055 (E-value: 3.6e-11, bitscore: 41.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAYSPSVPAVDPAARSACDEGRSRADEPVVFTDGHHFNLAASSD
                     LDSVASTAAGPLSVILQVTKRCNFDCSFCSETLQEPDPTLDALERMRDNLAGVPRVFLS
                     GGEPLLRRDFVDIVDLFAGTVIGVPTNATRGLQHAARLSGKIAFVNVGLEGPRATTNRV
                     RGDYDAVMAGIRAFQDAGLPLSLSAVVYRSTLAALPFTYQIADLLDAGKLKLILPLKKG
                     NALDLADHEFISLDEATLMFDRLAELRTVHDWRPALRLTAWTPDTEGHMIVVGPSGQAS
                     AWPVYGAPDLLEPLGNLLDEPIAAIWARYRFQRNHYAKYLGRSIRALTRAERPPSGRPL
                     LRISHA"
     gene            complement(4731..5045)
                     /locus_tag="FRANCCI3_RS09140"
                     /old_locus_tag="Francci3_1815"
     CDS             complement(4731..5045)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436251.1"
                     /locus_tag="FRANCCI3_RS09140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1815"
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_011436251.1"
                     /transl_table=11
                     /translation="MTAAPVPLSDDEIERRLRELPGWSRVDDEITRTFGIRYHGAVALI
                     VHVADIERLIGHHADIDLRWDSIRFGITTHDAGHRITDADFDLARRIDDIARAHGAEPS
                     "
     gene            complement(5045..5596)
                     /locus_tag="FRANCCI3_RS09145"
                     /old_locus_tag="Francci3_1816"
     CDS             complement(5045..5596)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436252.1"
                     /locus_tag="FRANCCI3_RS09145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1816"
                     /product="flavoprotein"
                     /protein_id="WP_011436252.1"
                     /sec_met_domain="Flavoprotein (E-value: 3.6e-10, bitscore:
                     38.0, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGRPVLHLVVCAAPPAAQINELIRHVRGEGWAVCLIPTPAAAT
                     WLDVRLLEELTGHPIRSRPRQPDEPRLPPADAVAVVPATFNTINKCAVGINDNSALGVV
                     NEAIGLGLPVVVAPYVKPTLAAHPAFARALRDLAAYGFTVLPTNAIGPPDGTTTFAWRP
                     VLDSLPAARPASEISAQEDP"
     gene            complement(5593..7176)
                     /locus_tag="FRANCCI3_RS23335"
                     /old_locus_tag="Francci3_1817"
     CDS             complement(5593..7176)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436253.1"
                     /locus_tag="FRANCCI3_RS23335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1817"
                     /product="hypothetical protein"
                     /protein_id="WP_011436253.1"
                     /transl_table=11
                     /translation="MGKTSQRVEQEELRARMRAVGMSHDEIATEFARRYSYRPRAAHRV
                     AHGWTQAQAAGHINAHAARVGLDPGGAAPLTGPGLCERELWPQPNNRRRPTPQFLALLA
                     EVYGTSIHNLIDLDDREQMPPADLLLISTIRVEGVPASAVGSLARTKAVDVEAPLMTAL
                     NRQQFLLAVSISGVAAVTPRQPAAPAVSVNTSRAPAGDDLLADLREAVTVPAEWSADPG
                     VTSAGAFADLEARGRECHNRYQRADYAGAARLLPAVVRGIDTLVADSPAGVDHRAVRRS
                     QAVAYIAAAKLATRTGDHDLAWLAADRGQHAALAADTPVLLATARRQIACVFHDTGRLA
                     DAERVALSALDALNRRRGDEDHPDIVSARGALLLLAAMTSVRQGERAQARRRLTAAAEQ
                     AGTLGRDDNRLWSAFGPTNVAIHTLTAALTLDDPTEAVAVGEQIDTRLLPPPLVGRRAR
                     LHLDLADGHARLGEDAVAAVHILDVARRAPQLLRVDPTARAVLATLLSRARGSIVSVLR
                     DVAEQAGVAA"
     misc_feature    complement(7494..7508)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    8353..8370
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            8373..9605
                     /gene="fxlM"
                     /locus_tag="FRANCCI3_RS09155"
                     /old_locus_tag="Francci3_1819"
     CDS             8373..9605
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436255.1"
                     /locus_tag="FRANCCI3_RS09155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1819"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_011436255.1"
                     /sec_met_domain="PCMT (E-value: 1.4e-45, bitscore: 153.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQHEESSTAAAVLRAAMVDELRELGAVRDPRVARALAVVPRHL
                     FAPGADLAAAYAATGTVVPVRDAVGRMVSTVSAPHIQAMMLEQARVAPGMRVLEVGSAG
                     YNAALLAELVGETGEVTTVDILPGVAERARRCLDAAGYGRVRVVLADAEGGVPDHAPYD
                     LVLVTTAVRDIPSAWTDQLAPGGRLVVPLRLRGQTRSVVFEADGGRLVGHDAQVCSFVP
                     LAGAGAFPEQVLALDGDDVVVRLDDAAPVDVDEVRQALTWPRVKTWSGVHSGEEPFDDL
                     LLWLAVGLENSGLLLARQAAVTRGTVAHAWSLGMPAVVGKGSLAYFSLSAKVPGRVSRE
                     FGVQAQGPAAELLTSQFIERIRAWKADRPARIEAFPAGTPDAALPAGGVFLDRPHRRVV
                     VSWPSGPEVPV"
     gene            9733..9918
                     /locus_tag="FRANCCI3_RS09160"
                     /old_locus_tag="Francci3_1820"
     CDS             9733..9918
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006541249.1"
                     /locus_tag="FRANCCI3_RS09160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1820"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_023842039.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4e-18, bitscore:
                     63.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQNAPAPVVDPDSALDLDEFDLDVTVVESGQLVEELIRMTDDG
                     CGTTCQSACPNTCPGD"
     CDS_motif       9733..9831
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTPQNAPAPVVDPDSALDLDEFDLDVTVVESGQ"
                     /locus_tag="FRANCCI3_RS09160_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9832..9918
                     /prepeptide="core"
                     /locus_tag="FRANCCI3_RS09160_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-4.30"
                     /molecular_weight="2794.1"
                     /monoisotopic_mass="2792.2"
                     /core_sequence="LVEELIRMTDDGCGTTCQSACPNTCPGD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTPQNAPAPVVDPDSALDLDEFDLDVTVVESGQ"
                     /leader_location="[9732:9831](+)"
                     /alternative_weights="2812.2"
     gene            10001..13225
                     /locus_tag="FRANCCI3_RS09165"
                     /old_locus_tag="Francci3_1821"
     CDS             10001..13225
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="FRANCCI3_RS09165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1821"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_011436257.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.6e-194,
                     bitscore: 645.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-17,
                     bitscore: 62.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.4e-28, bitscore:
                     95.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTIRDPGGSAAPRSAIPRATPSEVRDSDLASGPQVAGLGARASD
                     ALYRVAGPGVVRVAEPMPGLAALPWPDLGDGGEETERWCQWLREAWACAPFAAAVQAAS
                     PVLARRIAQVCAGGDLPARQARSAVLSLMRYRLRLVSRATPFGLFAGVGPARPGTALTV
                     YEDPTHHRMLARVDTAWLFDVLDQLEGVPGVLDVLPVRANDLAFVRDGRLVLPFEGPRA
                     GSDAEVSTAETSVRYTQAVAAVMKAAAGPVLVGTLAAQLGTEFPAAPARVLRGMLSTLV
                     ERRFLLSGLRPPSTELDPLGAVLATLRAIGADPVPEAADLVDALRRRSRGLADITEPWT
                     SQPATPDTAAPTSSPSGRRPPIALDMRAGVGLELPRLLLREVEAAVDLLVRLAPAPRGN
                     AAWRDYHDRFLERFGAGAFVPVNSLINCETGLGLPAGYRGTTLGPATAGPLSDRDALLL
                     ALAQTAAARRDREVTLDAESLALLRTSDAVGWTCQPHTELRFRLHAADRRAVERGAFDL
                     AVEGVSRAAGTTLGRFLDLANEADREEMTSALRALPTRQPGALLVQLSGGTLSATAANV
                     SRAPRILDHLIALGEYQPPDRGMIPVTDLAVTADGSGLWLVSLSLGRPVEPVAFHAVEL
                     TRHGHPLLRFLSEIGTSRAAPCAPFSWGAARRLPFLPRLRHGRTILAPARWLLAPADLP
                     GPDATFARWSDDLAAWRDQWGVPDQVFLGSDDRRLLLDLTEPAHLHLLRADLGRATRAT
                     LREAPPPDAAGWIGGRTHEIVLPLAAPPTPTAEVPRPRRPARIATSADAHLPGDGAWLY
                     AKLYAQPDRQVTILTERLASLWEHWDTPPLWWFQRYQDPAPHLRLRIRLIDPDGFGDAA
                     RRVGRWATALRQAGLLDQLQFDTYLPETGRFGGASTLAATETLFAADSTAALAQLAASA
                     RGATHPHALVAVSLLDLAAGCLPGDDAARWLVEQLPRTQGPPIDRAQHDAAVHLADPRE
                     SQATMHTLPGGKEILTAWARRRARLADYQTALTSAGDGLTTRGLLPTLMHLHQFRMTGP
                     SVQAERDCARLTRAVALSVLRRREMA"
     misc_feature    10409..10411
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10598..10879
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FRANCCI3_RS09165_Lanthipeptide_LanB_R
                     RE.1"
                     /evalue="7.30E-20"
                     /identifier="RREFam001.1"
                     /label="FRANCCI3_RS09165"
                     /locus_tag="FRANCCI3_RS09165"
                     /protein_end="293"
                     /protein_start="199"
                     /score="62.5"
                     /tool="antismash"
                     /translation="VRANDLAFVRDGRLVLPFEGPRAGSDAEVSTAETSVRYTQAVAAV
                     MKAAAGPVLVGTLAAQLGTEFPAAPARVLRGMLSTLVERRFLLSGLRPP"
     gene            13222..14448
                     /locus_tag="FRANCCI3_RS09170"
                     /old_locus_tag="Francci3_1822"
     CDS             13222..14448
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138950.1"
                     /locus_tag="FRANCCI3_RS09170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1822"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_011436258.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-42, bitscore:
                     143.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPGTAEDTGRDTLSSRALAASAAIADQLADPAAVPRGPGRRRGQ
                     SLAGGAAGIALLHLERARTGHGDPAIANAWLRAATRDPASAGPNASLYFGAPTLAFVLD
                     AAGRPDQLTQAVTTLDTATIAVTQRRLAAADARLRAGLRPPLAEFDLIRGLAGLGRYHL
                     RRQHPIITDVLTHLVRLTQPPASGDGLPGWWTDLDPSGASSRDYPHGHGNAGMSHGIAA
                     CLALLALANSRGTEVDGHREAIERICAWLDGHQQPGIAGWPGIVTPTPGHDVRQQRLSW
                     CYGTPGIARAYQLAGLATSDPRRCEKAETALHACLDDAARLELTTDIGLCHGLAGLVHT
                     TSRVAADATTPELAQLLPTLVARLLDQYPTAPHDPELLDGLAGVALALHTAALGSAPVT
                     GWDAALLLA"
     gene            14457..15308
                     /locus_tag="FRANCCI3_RS09175"
                     /old_locus_tag="Francci3_1823"
     CDS             14457..15308
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436462.1"
                     /locus_tag="FRANCCI3_RS09175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1823"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_011436259.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-35, bitscore:
                     121.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRNDSDPRPCIDDAPQNDEDGCSPRHPWRQATMHFADYAQADAA
                     GRDLGAALVAAENDHLLDAWWFIRKSPCWRLRFQPTSPVDDAATKAVHDHLHALRERGR
                     IAGWSETLYEPETFAFGGPPAMQIAHRLFHQDSRHLLTTAPRSRARARALSILACVSLM
                     RSAGQDWYEQGDIWARVAEHRRCPPDLVSDSRSLEPSLTRLLSAQTPDTNALGKDADLA
                     HWIGAFGATGRDLGRLAHDGTLQRGLRAVLAHHIIFHWNRAGLSHDAQAVLARAASTVV
                     LG"
     gene            15305..16480
                     /locus_tag="FRANCCI3_RS09180"
                     /old_locus_tag="Francci3_1824"
     CDS             15305..16480
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRANCCI3_RS09180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Francci3_1824"
                     /product="hypothetical protein"
                     /protein_id="WP_023842038.1"
                     /transl_table=11
                     /translation="MTASPTTPPPLPQTVANWFPLVPRPRPPTIDRRQRLTEIEHLAHS
                     APGNARRTTNAAEALNKAALLASDCGLPDLAKDLCWRQFHVFDNAGPQPPALATAVLQP
                     LINLGRLELRADDPDRAYTFFNQIHHAVRTSTAVVLDGVTVNPARLFADDNTLLRARRF
                     TWTVLLGDGTRALARAGRWDDAVAHLHRHHGIGRRLLDGRQTLILASHLAGESEAARTA
                     LATSVTPTPWERAVAAVLGILCRHGSEPQAIGAALDDLRASSRDPTHPVFQNRLGLTLL
                     DLATDATDQKWIASAILAGLRDGHDGRCAADALAHPRLQQHLSPAHRVDLVERVKTAGI
                     QRPPPTTFRDAMTTATLAAERGLRDALAGPLEGGRLITRRPDQSAARGEAG"
     gene            complement(16434..17288)
                     /locus_tag="FRANCCI3_RS09185"
                     /old_locus_tag="Francci3_1825"
     CDS             complement(16434..17288)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020694.5"
                     /locus_tag="FRANCCI3_RS09185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1825"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_011436261.1"
                     /transl_table=11
                     /translation="MTPRRIGLLHPGSMGARIGEILRTAGHEVLYCPTGRSPQTLQRAQ
                     DAGLLPVSRLDDLCDSTEILMSLCPPEAALDVARAVAAAGFTGLYVDANAVNPERMRAI
                     ERLMTAAGGTIVDACLIGPVPTRQDTTRMYLAGDARHAGEISGLFTGSTVQVIVFDGQV
                     GAASALKIAHSSFAKTSRVLAALAHALAAEYGVQQALTDEARRRSRPALAEPDFFATVA
                     ARAWRWGPELAQAAESYRTVGLPDAMLRGAEELLRTWYEHKDIEHAPLNLLLRELHSGQ
                     DGG"
     gene            complement(17304..17483)
                     /locus_tag="FRANCCI3_RS09190"
     CDS             complement(17304..17483)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRANCCI3_RS09190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_131728935.1"
                     /transl_table=11
                     /translation="MIEMLSVRRVESARRLTQVLTILDRPAYRGQALAVGLRDQIRDGG
                     AVPAYGSKSLGRRL"
     gene            complement(17525..17839)
                     /locus_tag="FRANCCI3_RS09195"
                     /old_locus_tag="Francci3_1826"
     CDS             complement(17525..17839)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436262.1"
                     /locus_tag="FRANCCI3_RS09195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1826"
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_011436262.1"
                     /transl_table=11
                     /translation="MADAPVPLADDEIEAQLRELSGWARAGQEITKSFRVRYHGGVALI
                     VHVADVERLIGHHADIDLRWDSIRFGITTHDAGHQITTADFDLARRIEAIAQAHNAEPL
                     "
     gene            complement(17841..19295)
                     /locus_tag="FRANCCI3_RS09200"
                     /old_locus_tag="Francci3_1827"
     CDS             complement(17841..19295)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436263.1"
                     /locus_tag="FRANCCI3_RS09200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1827"
                     /product="hypothetical protein"
                     /protein_id="WP_011436263.1"
                     /transl_table=11
                     /translation="MSRSSRRAEQDELRARMRAAGMSHDEIAVEFARRYGYRPRAAHRH
                     AHGWSQVQAAGHINSHAAQVGLDPRGAAPMDGPRLSELENWPLPNNRRRPTPQLLALLA
                     EVYGTNIHNLIDLDDREHFTPADTLLISRVDRIEPAAGRILPAPRAAPSARGLVQPGSP
                     AHIDRRDFVTATATALTFGRTAPRHVDPALVDYFGQQLEGHYRADVMLGPRELISTVTV
                     QHTLISNLVATARGETRLALLRSSAAYASLIGWLHQDAGDLETSSVWRGVALEVAQRSR
                     DPQLVAYALLNHASVRTDLADGLGALDLCGAVLADAGRLSPKMRVLALQQQAHGASLVG
                     DRATVDSALDQAAPLVERCDDGLPWGNACRRTSAYLEVQRATCYGRLGLVTAAAGLWRQ
                     ILDTTPANARRDRGVFLARQATACVQSGDVGRAVDAGRLAAALAVETGSVRIRRELAGL
                     RQAAQPLKGAAVGRDIDEIFAPEKET"
     gene            complement(19429..19728)
                     /locus_tag="FRANCCI3_RS09205"
                     /old_locus_tag="Francci3_1828"
     CDS             complement(19429..19728)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436264.1"
                     /locus_tag="FRANCCI3_RS09205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1828"
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_011436264.1"
                     /transl_table=11
                     /translation="MAEALTRDMIDEHLKTLDGWTTDGRRIERLYSIPHIQGAAFIVHI
                     AAIQDEFGHHSDATLGYKTVHVSISSSDIGGYVAEHDIELARRIQEIASAHGAR"
     gene            complement(19721..21280)
                     /locus_tag="FRANCCI3_RS09210"
                     /old_locus_tag="Francci3_1829"
     CDS             complement(19721..21280)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436265.1"
                     /locus_tag="FRANCCI3_RS09210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1829"
                     /product="hypothetical protein"
                     /protein_id="WP_011436265.1"
                     /transl_table=11
                     /translation="MSRSSRRAEQDELRARMRAAGMSHDEIAVEFARRYGYRPRAAHRH
                     AHGWSQVQAAGHINSHAAQVGLDPRGAAPMDGPRLSELENWPLPNNRRRPTPQLLALLA
                     EVYGTNIHNLIDLDDREHMPPADMLVITTTRQDARPTPPTGSPVNLALPAAPCFSPTAP
                     CVQSGRGHGAARGLRLDGPAGSMEWVDALGRRGFTLLAGSAVVAGLAGAGRARHVDPAL
                     ISYFDGQLQGHYHADMLLGAGALIGTVASQYEVITQLLDAADGSTRRGLAKVGSSFAAF
                     AAWLWLDAGDAVAAMRCHDAALELAHRCGERDAVACALVDRAMAFTDLGNAAAVIDLCQ
                     AALGDARQLAPEVQVFALQQQAHGASLRGDRRQVDLLLDQAGRLVEHVEVEEYGTACRR
                     TDGYVEVQRATCYGRLGLADDADRLWQQIIPAAPASARRDVGVWSARHAVAAARQGEPE
                     RAVDLTRQASALAVETGSARARRELAAVAAAMAPWRAHPLGQELADVLTPFTTDETGRE
                     HG"
     gene            complement(21682..21993)
                     /locus_tag="FRANCCI3_RS09215"
                     /old_locus_tag="Francci3_1830"
     CDS             complement(21682..21993)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRANCCI3_RS09215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Francci3_1830"
                     /product="hypothetical protein"
                     /protein_id="WP_011436266.1"
                     /transl_table=11
                     /translation="MRSHRHTVPPALRPIVLLARMRELLPPEKLASLLATFTPPLDPTD
                     PDWADLCSALDDYDRAARLGLGLDEARTRVDIAAMIIYVRCCGASPHESVATSTRPAR"
     gene            complement(22039..22326)
                     /locus_tag="FRANCCI3_RS09220"
                     /old_locus_tag="Francci3_1831"
     CDS             complement(22039..22326)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRANCCI3_RS09220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Francci3_1831"
                     /product="hypothetical protein"
                     /protein_id="WP_011436267.1"
                     /transl_table=11
                     /translation="MTVDYPHTDSPAIVDADLPGQADVGLLSALVHVLAPRLFAIVAEP
                     SYGDIHVVAWGLRFDGYVALISTDGQMVGSFSSFSPPRSGSRPRFRRGRR"
     gene            complement(22323..22703)
                     /locus_tag="FRANCCI3_RS09225"
                     /old_locus_tag="Francci3_1832"
     CDS             complement(22323..22703)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436268.1"
                     /locus_tag="FRANCCI3_RS09225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1832"
                     /product="hypothetical protein"
                     /protein_id="WP_011436268.1"
                     /transl_table=11
                     /translation="MSEPVDAACPPWCDQPTGHLQVEPAGPGDYHISAFIVIDLPEIAG
                     IREGTAVQVAIEQYVTSTTIYDPLISLAVGDDDPDSEALTLDEADALATALSRAVTAAR
                     DAPAHPPSKQGAVPRPPAGEQP"
     gene            complement(22700..23404)
                     /locus_tag="FRANCCI3_RS23340"
                     /old_locus_tag="Francci3_1833"
     CDS             complement(22700..23404)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436269.1"
                     /locus_tag="FRANCCI3_RS23340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1833"
                     /product="ATP-binding protein"
                     /protein_id="WP_011436269.1"
                     /transl_table=11
                     /translation="MTTVLAITPSTTPEQPAEPLPQYIRHYPARPQSVRPARHDVAAQL
                     RRWGLDSLIDSATCVTSELITNAYAASHEARRPHGEQDTRSRIGMRLTYSHRDLIVEVW
                     DGGPGRPTRRTAGPDAENGRGLPLVAALARDLGYYPVRVRTPDGYRTKGKIVWAALAHD
                     LPPIQHLPDKPAEDLPRRDPPPPTSDGGPDADIFDHALLQRVLDALRNLGDDWTTITNS
                     GDPRDGEQVTTP"
     gene            23524..23772
                     /locus_tag="FRANCCI3_RS09235"
                     /old_locus_tag="Francci3_1834"
     CDS             23524..23772
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FRANCCI3_RS09235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Francci3_1834"
                     /product="hypothetical protein"
                     /protein_id="WP_011436270.1"
                     /transl_table=11
                     /translation="MIPGRVGGSGRAVGRGIRGTGRGGVGDQRQVLVCEQDQVARPWPP
                     AARADGAVTDVGIEQADRGASKPLEVTIERVVTLVVR"
     gene            complement(23849..25087)
                     /locus_tag="FRANCCI3_RS09240"
                     /old_locus_tag="Francci3_1835"
     CDS             complement(23849..25087)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011436271.1"
                     /locus_tag="FRANCCI3_RS09240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Francci3_1835"
                     /product="hypothetical protein"
                     /protein_id="WP_011436271.1"
                     /transl_table=11
                     /translation="MSPPPGCSTCWPAADVRRLVEHAEGRIAAATAALWPRTETTFGPT
                     LTAGSAILRQVHVGPETLCATLRPAGTPLTGVVLGDCGDLAAVLSDEAGDADATAQEDA
                     TAREAEQLTALVAYSGLRVAGPIATVRGVMFAPWVTGASLTSRLQDRPAALTHLLTTLM
                     DDLGELHRDPPEQLRQVAAPTTLRTHPRILAQALAHSVNHLHSAPAQPAGTGELGALLG
                     TLSLRLTRLAAQLDPLLVTRTGIAFGGLTPRHVLYPETSSRPVLVSPDLGPGGEPADIG
                     TLLGHLHLLALDSPPTVRSDFVEGIEAYLAGRVAAHGAEWNGWLTLVMTTWAATVYDTV
                     VAALTLPAALPLDPAIGQLAARPLPALADVKTLTGELRRRGALPALNATLAALAGRPAD
                     DDDVERATTTARR"
ORIGIN
        1 gtcgcggccc aggcccagct cccgacccac gtccccgagc cacgatgcgc cgaccttccc
       61 cggggccagg acgacgttga ccgcgtggac ccgcctgacc ccgggaccat ccaactccag
      121 ctcccaccgg aaatcggaac gtcctgacgg gcggataccg atacacgtcg tacggcaggc
      181 gaccgtcgcc ctcgccgcca gacgcgtccg caaccggctg agcatccgag gtagctggtc
      241 ggtcccgacg tgacggaccg gataatgaac atattctaat ccggcgacct tcgcgcgttt
      301 ctcgaaattt tctgcggctt cggcgtcccc gccgtgcagg tcggcccgct cgccggagcg
      361 aagaacctca tcgatcgcgt gctgccgcgc ggaaacgcga gaaggatcga atctgtggct
      421 gacggtgctc ccgatccgcg gtgacaagca cagcttgccg tccgagaaca gcccggcacc
      481 gccaaacccc cgggtcacca cgtcccctcg gctatcggag cccagagcgc caatccgctc
      541 ctccacatcg tcacctccgt cgaggaggag aaggcccggc gcgggcacat cagatcggta
      601 ggctgcaatc aaccccccgg ggccggcacc caccacgacg gtatggaaaa cccgcgcatt
      661 catcatcgtt cctctcgatg ggttacaggt agaggtgcgc cgcgcaatca acctgactca
      721 tgccggtagc gaggcaagag cgaccggaag gcgcagcagg gaagaagaat cgacggcaat
      781 cagggtgaaa tgccggtcac gagtctccgc cgatatcaat gcgccctttc ctccacctgg
      841 catcgacggc ggcggaccag agaaaagcgc gagcagtcga ggaatttctc caacacttga
      901 atactctcag gcatgcggga aggagtcgtt cgagcggcgg gtcaggaaac gctcacgtga
      961 tgccaagatt ccaaccttcc ggccaaaggg tgcagcgtgc accaacgcgg cgctcgcccc
     1021 gggtggccca ctgaccggga cgagaaactc acgaggtgac gccactatcc ccagcggacg
     1081 ggcgcgaacc attcccttca gcgcgaagct tcggttcggg gccgcggagc gccgtgagct
     1141 gggcagatgc ctcacgtgaa ggaagatcat tgccgctagg gatggcgaac actcgggaaa
     1201 cgttcgggag cagggtgaga cgagggggcg gaccgtgtcg actcgccggt cctctcgctg
     1261 gttgagagga acgaccagcc gagctgagat ttccatggta tggaatgaca gccgacacgg
     1321 gacccggagt accggattgc cggctcacca atggcgtcaa catgtcgtct atccagtccc
     1381 accgccggcc gagtgtgatg gtccggacat attcgatccg ctttcgcaag gatcagttgg
     1441 ctcgctagca aacggtacgg atgccgtcgt agcgctttct atgtctccca cccggagatg
     1501 gcaaagttct cccgccgcct gtggagatcg atgccgacac gggtgtatgg atacgtgctg
     1561 tcgggaatct cgtcgagggg aaaccaggcg atccgggcac acttttgggg ttccgcgttg
     1621 acgggttctc cgtgccagca ctccggctga aagaacaggc caaggcgcgc ttccccgcgc
     1681 tcgttccgga agtggaccgt cgaagcgaga gtaagcgagg cgggatcgag atgaaggcca
     1741 atttcttcac ggctctcgcg gcatagcgcg gaagcggcgt cctcaccatc ttcgagtttt
     1801 cctgacggga cgttccacca gccgtcggcg aatcccgtgc cggatcgcaa cgcgagcagg
     1861 accgcatcat cgcggatgag caggagcatg acgtcgatga cgctgcggta ccccatggtg
     1921 gcagtatctc ccgactgtgc tgaggaaacg gtcagcggct ggtcgggttg agcccgaggg
     1981 tcgtgagctg ctcggcgatc cagccgaccc gcgcgctggt ggacatgttc ggtggaatgt
     2041 cgaagatgcg ctgcccgacg gtggcgcaga tgctgcgcac gacgcggtcg gcggcgggtt
     2101 ggatgtcgag gaccttggac cggtaggggt cgccgatctg gtgctggtcg aacttgtcgc
     2161 agcagtagaa gaccgcgtcg tagacggacg cccaggcccg gcagaaggct tccatcgcgc
     2221 gcaggaccgg cgcgtggggt ccctctgggc cgccgggcag gacgagccag gcgtaggcga
     2281 ggacgttcgc gatcgtcttg tcacagatga tcatggtgtg ttggcgtgcg acgcggagtt
     2341 ggctggacag ctgggcggcg aacaagtcga cctcggtttc caggtcgaac tcgccgcggc
     2401 cgtgcacgac gatctcctcg atgaacgggg agttccgagc cggttcgggc acgcaggcga
     2461 cgtgcacccc acgctcccgg aaatgtgccg ccagggcatg ggtgagcgtg gtcttgccgg
     2521 aggcgtgggt accctcgacg gccacgacga ggcagttgcg cagcatcagc ggactccttc
     2581 cgcggccaac gtctggtcgt cgcgaccagc cggtacggca ggcacggacg agggccgtgc
     2641 tggaggggta gtcgcgggag tcacagccgt tggacctgcg gcagggatgt cggtggtctg
     2701 gtcccaggcg gcggcctcga cgacatcgtc gagattgagc tggtcccact gataatggcc
     2761 cgtgctgcgc gccgcgacga gcgcgatcgc cagcgcgcgg agaacaacct gccgaaggat
     2821 ctgcggtgcc cccgccgagg cgccataccc cacccgtgca gggtcggcag aggtacccga
     2881 ctccgcgaac aggccgtgga gatgaaacgc ggtacacacg tcttccagta cgaccggcgt
     2941 ggagccgcgc gccgtgtcgt gaagacgcgc gagactgggc tgcgcggtct cgcccggcca
     3001 ggcggcggcg agggcggtga ttccgcgtgt aggtgcgccg gcggcggcga gcctcgccag
     3061 gtcgtcggcg agccggtggc ctgcgaggat cgccgcccgg cgtcgggcct gcaccagcag
     3121 ggcatcgagc ccggcggcga cgaggagagt ctccgccggg tcctcggccg cgacggcgtg
     3181 gaagccgaac cgcaacgtcc tctcggtcac cgccagagtg cggccccgtg gcagccgcag
     3241 gtacaccgct cccatggcgt ccggcgacgc ggcgcgggtc aggacggtga acgcggccaa
     3301 cagcggtgtg cgttcggcga acggccgccg ctcggcacca aaaggtgtgt cggcccagcc
     3361 caggttcgtt gcctcacgca tggctgatcc gcagcaaagg acgccctgat ggcggtcgct
     3421 cggcgcgggt gagggcgcgg atcgagcggc ccaggtattt ggcgtagtgg ttgcgctgga
     3481 accggtaccg cgcccagatc gccgcgatcg gctcgtcgag caggttgccc agcggttcga
     3541 gtaggtcggg ggcgccgtag accggccagg cactggcctg ccccgacggc ccgacaacga
     3601 tcatgtggcc ttcggtgtcc ggggtccagg ccgtcaggcg cagtgccggc cgccagtcgt
     3661 gcaccgtccg cagctcggcc agccggtcga acatcagcgt ggcttcgtcc aggctgatga
     3721 actcgtggtc ggcgaggtcg agcgcgttgc ccttcttcaa cggcaggatc aatttgagct
     3781 ttccggcgtc cagcaggtcg gcgatctggt aggtgaacgg caacgcggcc agcgtcgagc
     3841 ggtagaccac cgccgacagc gacaacggca gcccggcgtc ctggaacgcc cgtatcccgg
     3901 ccatcaccgc gtcgtagtcg ccgcggaccc ggttcgtcgt cgcccgcggc ccttccagcc
     3961 cgacgttcac gaacgcgatc ttgccggaca ggcgcgccgc gtgctgaaga ccgcgggtcg
     4021 cgttggtcgg cacgccgatg accgtcccag cgaacaggtc gacgatgtcc acgaagtccc
     4081 ggcgcagcaa cggctcaccg ccggacagga acacccgcgg caccccggcc agattgtccc
     4141 gcatccgctc caacgcatcc agcgtggggt ccggctcctg caacgtctcc gagcagaacg
     4201 aacagtcaaa attgcaccgc ttcgtcacct gaaggatcac cgacagaggg ccggccgccg
     4261 tcgaggcaac cgagtccagg tccgaggacg ccgcgaggtt gaagtggtgc ccgtcggtga
     4321 agaccacagg ttcatcagcg cgggaacgcc cctcgtcgca ggcggaccgc gccgcgggat
     4381 cgacggcagg tacggatggg gaatacgcga tcatcaggcc cttctcgacg taggcgcgca
     4441 cggcgaccgg gccagctgac cgccgccttc ctgacggtga gctgccgcgc cgacgctgaa
     4501 cgtccccagc gtcccaagag acccacatga tggtcattcc ctgcggagcg aacatctgat
     4561 tcgtgcgggt acaggccgct gacctgcccg aagacctgcc gatgaggctt catgttcgga
     4621 tcgatagcgg cgaatcgttc gtgtgcctgt tgggtattgt ggcgcgccac atgtgatcaa
     4681 caacgtgtgc gcccggcgcg gacgtccccg cgcgtgcagg ttggaggttc tcagctgggt
     4741 tcggcgccgt gagctcgggc gatgtcgtcg atgcgccgag cgagatcgaa gtcggcgtcg
     4801 gtgatccggt gaccggcatc gtgcgtggtg atgccgaagc ggatgctgtc ccagcgtagg
     4861 tcgatgtcgg cgtggtgacc gatcagccgc tcgatgtccg cgacgtgcac gattagcgcg
     4921 accgcgccgt ggtagcggat gccgaaggtt ctcgtgatct cgtcgtcgac ccgtgaccag
     4981 ccgggtagct cacgcagtcg tctctcgatc tcgtcgtcgg acaggggcac gggcgcagcc
     5041 gtcatcacgg gtcctcctgc gcggagattt cgctggcggg ccgggcggcg ggcagcgagt
     5101 ccagaacggg acgccaggcg aaggtggtgg tgccgtcggg gggaccgatc gcgttggtcg
     5161 gcaggacggt gaacccgtag gcggccaggt cgcgtagggc tcgggcgaag gccgggtggg
     5221 cggcgagggt gggtttgacg tagggggcga cgacgacggg cagaccgagt ccgatcgcct
     5281 cgttgacgac gcccagcgct gaattgtcgt tgatcccgac ggcgcacttg ttgatcgtgt
     5341 tgaaggtcgc ggggacgacc gccacggcgt ccgcgggcgg taggcgaggc tcgtctggct
     5401 gccggggtcg cgagcggatc gggtggccgg ttagctcctc cagaaggcgc acgtccagcc
     5461 aggtcgcggc ggccggcgtc ggaatgaggc agacggccca cccctcgccg cggacgtggc
     5521 ggatcagctc gttgatctgc gcggcgggcg gggccgcgca gacgaccaga tgcagcaccg
     5581 gtcgcccagc cgtcacgccg cgactccggc ctgctcggcg acgtcccgca ggacagagac
     5641 gatggaaccg cgggcgcggc tcagcagcgt cgccagcacc gcccgagcgg tcgggtcgac
     5701 ccgcagcagc tgtggagctc gccgggcgac gtcgaggatg tgcacggccg cgacggcgtc
     5761 ctcgcccagg cgggcgtgcc cgtcggcaag atctaggtgc aatcgcgcac gcctgcccac
     5821 cagcggggga ggcagcagac gcgtgtcgat ctgttcgccg acggcgaccg cctccgtcgg
     5881 atcgtcgagc gtcagggccg cggtgagggt gtggatcgcc acgttcgtcg gcccgaacgc
     5941 cgaccacaac cggttgtcgt cccggcccag cgtgcccgcc tgctcggccg cggcggtgag
     6001 ccggcggcgg gcttgcgccc gctcaccctg acggaccgag gtcatcgccg cgagcaggag
     6061 aagggcgccc cgcgcggaaa cgatgtcggg gtggtcctcg tcgcctcgcc gccggttcag
     6121 ggcgtcgagt gcgctgaggg cgacccgttc ggcgtcggcc agccgccctg tgtcgtggaa
     6181 gacgcaggcg atctgcctgc gtgcggtcgc cagaagcact ggcgtgtcgg cggcgagcgc
     6241 cgcgtgttga ccacggtccg cggccagcca cgctagatcg tggtcgccgg tcctggtcgc
     6301 gagcttggcg gcagcgatgt acgcgacagc ctgagaccgc cggaccgcgc ggtggtccac
     6361 gcccgccggc gaatcagcga ccagcgtgtc gataccccgc accaccgcgg gaaggagccg
     6421 cgccgcccca gcatagtcgg cccgctgata ccggttgtgg cactcccgcc cccgcgcctc
     6481 aaggtcagca aaggcacccg ccgaggtcac gccagggtca gcggaccact ccgctggaac
     6541 cgtgacggcc tcccgcagat cagcaagaag atcgtccccg gccggtgccc tactggtgtt
     6601 taccgacacg gcaggcgcgg ccggttgtcg gggtgtcacc gcggcaaccc ccgagatcga
     6661 cacggcgagc aggaactgct gccggttcaa tgcggtcatc agcggcgcct cgacgtccac
     6721 cgccttggtg cgcgcaaggg aaccgacagc gctcgcgggc acgccctcca cgcggatcgt
     6781 gctgatgagg agcaggtctg ctgggggcat ctgttcgcgg tcatcgaggt cgatcaggtt
     6841 gtggatactg gtgccataga cctcggcgag cagcgcgagg aactgcggtg tgggccggcg
     6901 gcggttgttc ggttgcggcc acagctcccg ttcgcatagc cccggcccgg tcaacggagc
     6961 ggcgccgccc gggtcgaggc caacccgggc ggcatgagcg ttgatgtgcc cagcggcctg
     7021 cgcctgggtc cagccgtgcg cgacccggtg ggcggcgcgg ggacggtagc tataacggcg
     7081 ggcgaactcg gtcgcgatct cgtcgtggga catgccgacc gcgcgcatcc gcgcccgcag
     7141 ctcttcctgc tcgacgcgct ggctggtctt gcccatgccg ctgtgcccct tccctggccg
     7201 tggacggcaa tccgtttcgg gcttcggtca ccgaccgcca tcgcaaccgt agtcgtcggc
     7261 gcacggccag aacagaaggg ctgagcggat cgaagtcacg gcatcgtgcg gtcgtgccgg
     7321 tcgcggcgcc cgcgagggcg gactaggcca caggctgctg gctcctcggc acgatctggg
     7381 cgacgagcac ggtcgtgtcc ttgtgggctc ctccggaacg aatcggcatg gtcgctacgg
     7441 acaaagcgac gcgcgcggca gtgttctcgc aggtcagcgg ctctgcgaag gggtgaacag
     7501 gatgttcgta gtggagggaa tgacttgcgt ccccgcgtcg gcgatcgttg tcaggcgtcg
     7561 ccgtttctgg ccatgcgtca gcgatgtggc ctgtcgctgg ctttccgtca tccgatctgg
     7621 cctgggctgg ttcccacggc gtccgatctg gcatcttgtc ggctcgcccg cgagccgaac
     7681 ggcgtgggag tcggtctctc cgctagaaag gggccagatc ggatgacggc cggcgggctc
     7741 gcacacgaca ccgcacatgg ccccgcctca ggtcagtcac tcccggtggg tcagatcgac
     7801 tgtcgcctgg caatcgtggt gggagcgact ccctggagga acacggcggt cacgcccaca
     7861 ctggtcagct cggccggcgc gagagagcga ggggctgtgg aggaggtctt cgggtcggtc
     7921 cgccttgctg gaaggatcgt ccacgttgac gacggccgcc tgaggcgcgg cggtccgcat
     7981 gagtggagga cgcagaggga acccgctgat ggaccccgag tacgagctga atctgcgcct
     8041 agtcgacgcc ggccctctgg cgagtggcga cgccacccaa caccaacgat gagcgcggct
     8101 ccggtaacac gggtccgtca gtttacacga cgaccagcga ctgaccgttc ttccgcaggc
     8161 ccctgcattc ctaaagtcac agagcgcccc tgccgcctgt gcctgcgtgc tgcgctgcgc
     8221 tgcgcgtcga gaacagaaca cgcacagccc gccgggcggg tactccccga agcgcgatgg
     8281 gggtgtccct cccagaccaa ttccgcagcc aaaggcgaat gccccgggca tccaggccac
     8341 gggccgctgt ccaatcccgc agtgaggatt cgatgaccat tcagcatgag gagagttcca
     8401 ccgcggctgc tgtgttgcgc gcggccatgg ttgacgagct gcgggaactc ggcgcggtcc
     8461 gtgacccgag ggtggcgcgt gcgttggccg tggtgccgcg gcatttgttc gcgccgggcg
     8521 cagatctggc agcggcgtac gcggctacag ggacggtcgt cccggtgcgc gacgcggtgg
     8581 gtcggatggt cagtacggtg tcggcgccgc acatccaggc gatgatgctg gagcaggcgc
     8641 gggtggcgcc ggggatgcgg gtccttgagg tcggttcggc gggctacaac gcggcgctgc
     8701 tcgcggagct cgtcggcgag acaggcgagg tcactaccgt cgacattctg cccggggttg
     8761 ccgagcgcgc ccggcgttgt ctggacgcgg cgggctatgg ccgggtgcgg gtggtgctgg
     8821 ccgacgccga gggtggcgtg cccgaccacg cgccctatga cctggtgctg gtgacgacgg
     8881 cggtccgtga cattccctcc gcgtggacgg accagctcgc gcccggcggc cggctggttg
     8941 tgccgctgcg gctgcggggc cagacacgct cggtcgtgtt cgaggccgac ggcgggcggc
     9001 tggttggcca cgacgcccag gtctgtagtt ttgtcccgct cgcgggtgct ggggctttcc
     9061 cggagcaggt gctggcgttg gacggggacg atgtcgtggt ccggctggac gacgcggccc
     9121 cggtggacgt ggacgaggtc cgccaagcgc tgacctggcc gcgggtgaag acctggtcgg
     9181 gtgtccacag cggcgaagaa ccgttcgatg acctgctgct gtggctcgcg gtcggcctgg
     9241 agaactctgg tctgctgctg gcccggcagg ctgcggtcac gcgggggaca gtcgcccacg
     9301 cgtggagcct cggcatgccg gcggtcgtag gaaaaggcag tctcgcctac ttctcgctca
     9361 gtgcgaaggt tcccggccgt gtgtcccgcg agtttggcgt tcaggcccag ggtcccgccg
     9421 ccgagctgct gacctcccag ttcatcgaac ggatccgcgc gtggaaggcc gatcggccgg
     9481 cccgtatcga ggcattcccc gcgggtactc cggacgccgc gctgcccgcc ggcggcgtgt
     9541 ttctcgatcg ccctcatcgg cgtgtcgtcg tctcctggcc gtccggcccg gaggttcccg
     9601 tctgagtgcg ggaaccgtcg tggcgcctca cgggagggca cacgccctcc cggctggcgt
     9661 ggccatccgg ccgtaggcgc cagcacggcc acggcgatgt ctctattccc tattccttct
     9721 caaggaggtt ccgtgacccc ccagaacgcc cccgcgccgg tcgtcgatcc cgattccgcg
     9781 cttgacctcg acgagttcga cctcgacgtg acggtggtcg agtccggcca gctcgtcgag
     9841 gagctgattc gcatgaccga cgacggctgc ggcacgacct gccagagcgc ctgcccgaac
     9901 acctgccctg gcgactgaac ccggccggaa catgacctga gcccggtccg gccgacaagc
     9961 tgcctggccg gaccgggctc gccggacagg aatgacgacc atgccgacca ttcgcgaccc
    10021 aggcgggtcc gctgcaccac gctcggcgat cccgcgagcc acgccgtcag aggtccgcga
    10081 ctccgacttg gcgagcggcc cgcaggtcgc cgggctcggc gctcgggcca gcgacgcgct
    10141 gtacagggtg gctggcccgg gtgtcgttcg ggtggccgaa ccgatgccag gtctggccgc
    10201 gctgccttgg cctgaccttg gggacggggg cgaggagacc gagcggtggt gccagtggct
    10261 gcgcgaggct tgggcgtgtg cgccgttcgc cgcagccgtg caggccgcga gcccagtgct
    10321 cgcgcgccgg atcgcccagg tgtgcgcggg cggcgatcta cccgcacggc aggcacgtag
    10381 cgccgtgctg tcgctcatgc ggtaccggtt acggctggtg agccgagcta caccgttcgg
    10441 cctgttcgcc ggggtcggcc cggcccggcc cggtaccgcg ctcaccgtgt atgaagaccc
    10501 gacgcaccat cgcatgctgg cacgggtgga cacggcgtgg ttgttcgatg tgcttgacca
    10561 gctcgaaggc gttccgggtg ttctcgacgt cctgcccgtc cgcgcgaacg atctcgcctt
    10621 cgttcgtgat ggtcggctgg tactgccgtt cgagggcccg cgagccggga gcgacgccga
    10681 ggtgtccaca gccgagacct cggtccgata cacacaggct gtcgcggcgg tgatgaaggc
    10741 tgcggccgga cccgttctcg tcgggacgtt ggccgcccag ctcggcaccg agttcccggc
    10801 cgcgcctgcg cgggtgcttc gaggcatgct ctcgacactg gtcgagcggc ggttcctgct
    10861 gtccgggctt cggccaccgt ccaccgaact cgacccgctc ggcgcggtcc tcgcgacgct
    10921 gcgggcgatc ggtgccgacc cggtacccga ggcggccgat ctcgtggacg ccctgcgccg
    10981 ccgctctcgc gggctcgccg acatcacgga accgtggacg tcacagccgg cgaccccaga
    11041 caccgcagcc ccgacctcaa gcccctccgg gcgccggcct cccatcgccc tcgacatgcg
    11101 ggccggcgtc gggctggaac tgcctcggct gctcctccga gaggtagaag cagccgtcga
    11161 cctgctggtc cggctcgcgc cggcaccccg gggcaacgcc gcctggcgcg actatcatga
    11221 tcgatttctt gagcgctttg gtgccggcgc gttcgtgccg gtcaactccc tgatcaattg
    11281 tgaaaccggg ctcggcctgc ccgccggata ccggggaacc acactcggcc cggcaacggc
    11341 cggcccgctc tcggaccgcg acgcgctgct gcttgccctg gcgcagaccg cggcggcccg
    11401 ccgagaccgc gaagtcaccc ttgatgccga gtcgctcgcg ctgctccgca cgagcgacgc
    11461 ggtgggctgg acctgccagc cccacacgga gctgcggttt cggctgcacg cagcagaccg
    11521 ccgcgcggtg gaacgcggcg cgttcgacct cgctgtcgag ggagtctcac gggccgccgg
    11581 gacaactctg ggccgcttcc tcgacctcgc caacgaggcc gaccgcgagg agatgacctc
    11641 ggcacttcgc gcgctgccga cccgccagcc gggggcactt ctcgtccagt tgtcgggtgg
    11701 cacgctgtcg gccaccgctg cgaacgtctc ccgcgcgccg cgcatcctgg accatctcat
    11761 cgcgctcggc gagtaccagc cgccggaccg cgggatgatc cccgtgacgg acctcgccgt
    11821 caccgcagac ggttcgggtc tgtggctggt ctcgttgtcc ctgggccgac cggtggagcc
    11881 ggtcgcgttc cacgccgtcg aactcacccg tcacggacac cccctgctcc ggttcctcag
    11941 cgagatcggc acttcccgcg ccgccccctg cgcgccgttc tcctggggcg cggcccgacg
    12001 gctgccgttc ctgccacgcc tgcgccacgg gcggacgatc ctcgccccgg cccgctggct
    12061 cctggccccg gctgacctgc ccggaccgga cgccaccttc gcccggtgga gcgacgacct
    12121 cgcggcctgg cgggaccaat ggggcgttcc cgaccaggtc ttcctcggca gcgacgaccg
    12181 ccgcctcctg ctcgatctga ccgagcccgc ccacctccac ctgctgcgcg cagacttggg
    12241 ccgcgccacg cgggcaaccc tgcgggaagc accgccgcct gacgcagccg gatggatcgg
    12301 cgggcggacc cacgagatcg tcctcccgct cgccgcacct ccgaccccga cggcggaggt
    12361 accgcgccca cggcgcccgg cgcggatcgc gacctcggcg gacgcccatc tacccggaga
    12421 cggcgcctgg ctgtacgcca agctctacgc ccagcccgac cgtcaggtca ccatcctcac
    12481 cgaacgcctc gccagcctgt gggaacactg ggacaccccg ccgctgtggt ggttccagcg
    12541 ataccaggac ccagccccac atctgcggct acgaatccgc ctcatcgacc ctgacgggtt
    12601 cggcgacgcg gcccggagag tgggccgctg ggcgaccgca ctgcgccaag ccggcctact
    12661 ggaccagctc cagttcgaca cctaccttcc agagaccggc cgcttcggcg gcgcctcgac
    12721 gctcgccgcc acggagacgc tgttcgccgc ggactccacc gccgcactcg cccagctcgc
    12781 agcctccgcc cgcggtgcca cccaccccca tgcgctggtc gccgtgagcc tgctcgacct
    12841 cgccgcgggc tgcctacccg gagacgacgc cgcccgctgg ctcgtcgagc agctaccacg
    12901 cacgcaggga ccgccgatcg accgcgcgca gcacgacgcc gccgttcacc tcgctgaccc
    12961 gcgcgaaagc caggcgacga tgcacaccct gccgggcggg aaggagatcc tcaccgcctg
    13021 ggcgcgccgc cgggcgaggc tcgccgacta tcagacggcg ctcacctcgg ccggcgacgg
    13081 actcacgacc cgcggcctct tgccgacgct gatgcacctc caccagttcc ggatgacggg
    13141 gccgtccgtc caggcagagc gcgactgcgc ccgcctcacc cgcgccgttg cgctcagcgt
    13201 tctccgccgc cgggagatgg catgaatcca ggcaccgcgg aagacaccgg ccgcgacacg
    13261 ctctccagcc gggcactggc cgcctcagcg gcaatcgcgg accagctcgc cgaccccgcc
    13321 gccgttcccc gaggccctgg ccggcggcga ggccagtccc tcgcgggcgg tgcagccggc
    13381 atcgcgctgc tccacctcga acgagcccgc accggccacg gcgaccccgc catcgccaac
    13441 gcctggctac gggcggcaac ccgagaccca gccagcgcag ggcccaacgc ctccctctac
    13501 ttcggcgccc ccaccctcgc cttcgtactc gacgccgcag gccgcccaga ccagctcacc
    13561 caagcggtca ccacactcga caccgcgacc atcgcggtca cacagcgacg acttgccgcg
    13621 gctgacgccc gcctccgcgc gggcctccgc ccgccgctcg ccgaattcga cctcatccgc
    13681 ggcctcgccg gcctcggccg ctaccaccta cgccgccagc acccgatcat caccgatgtc
    13741 ctgacccacc tcgtccgtct cactcagccc cctgccagcg gagacggact acccgggtgg
    13801 tggaccgacc tcgaccccag cggcgcatcc tcccgtgact acccacacgg tcatggaaat
    13861 gccggaatgt cccacggcat cgccgcctgc ctcgccctgc tcgcactagc caacagccgc
    13921 ggcaccgagg tcgacggcca ccgggaagcg atcgaacgga tctgcgcctg gctcgacggg
    13981 caccagcagc ctggcatcgc tggctggccg ggcatcgtca ccccgacacc gggccatgac
    14041 gtcaggcagc agcggttgtc ctggtgctac ggcaccccag ggattgcccg tgcgtaccaa
    14101 ctcgctggac tcgccaccag tgacccgagg cgctgcgaga aggccgaaac cgcgttgcac
    14161 gcatgtctcg acgacgcggc tcgcctcgaa ctgaccaccg acatcggctt gtgccacggc
    14221 ctggcagggc tggtccacac gacatcccgg gtcgcggccg acgccaccac acccgaactc
    14281 gcccagctcc tgcccaccct cgtcgcccgg ctgctcgacc aataccccac cgcgccgcac
    14341 gacccggagc ttctcgatgg cttggccggg gtggcgcttg ccctgcacac cgcggccctc
    14401 ggctccgccc ccgtgaccgg gtgggacgcc gccttgctcc tcgcgtgaga gaaccgatga
    14461 tccgcaacga ctccgacccc cgcccgtgca tcgacgacgc acctcaaaac gacgaagacg
    14521 ggtgttcgcc gcgccacccc tggcggcagg ccaccatgca cttcgccgac tacgcccagg
    14581 ccgatgccgc cggccgggac ctcggcgccg cgctggtggc cgccgaaaat gatcatctgc
    14641 tggatgcgtg gtggttcatc cgcaagtccc cctgctggcg gctccgcttc cagccgacct
    14701 caccggtaga cgacgcggca accaaagcgg tccacgacca tctccatgct ctgcgcgagc
    14761 gcggccggat tgccggctgg agcgaaaccc tgtacgaacc ggaaaccttc gccttcggcg
    14821 gcccgcccgc catgcagatc gcgcaccggc tcttccacca ggacagccgc cacctgctca
    14881 cgaccgcgcc ccgcagccgc gcccgcgccc gagcgctgtc gatcctggcc tgcgtgagcc
    14941 tgatgcgctc cgccggccag gactggtacg aacaaggcga catctgggcc cgggtcgccg
    15001 aacaccgccg ctgcccaccc gaccttgtca gcgacagccg ttccctggag cccagcctga
    15061 cccgccttct gagcgcacag acgccagaca ccaacgccct gggcaaggac gcggatctgg
    15121 ctcactggat cggtgccttc ggcgccaccg gccgtgacct tggccggctc gctcatgacg
    15181 gcacactcca gcgcgggcta cgcgcggtcc tcgcgcacca catcatcttc cactggaacc
    15241 gcgcagggct atcccacgac gcacaggcag tgctcgcccg cgccgcaagc accgtggtcc
    15301 tcggatgacc gccagcccga ccacgccgcc gccccttccc cagacggtgg cgaactggtt
    15361 tcccctggta ccccggccgc gtccaccgac catcgaccgg cgacagcggc tcaccgagat
    15421 cgaacacctc gcccactccg caccgggaaa cgcgcgcagg acgaccaacg ctgccgaggc
    15481 tctcaacaag gccgcgctcc tcgcgagcga ctgcggactg cccgacctcg ccaaggatct
    15541 ctgctggcgc cagttccacg tcttcgacaa cgccggcccc cagcccccgg ccctcgcgac
    15601 agccgtactg caaccgctga tcaatctcgg ccggctggag ctccgtgccg atgaccccga
    15661 ccgggcatac acgttcttca accaaatcca ccacgcggtc cgcacctcga ccgccgtcgt
    15721 tctcgacggc gtcaccgtca accctgcgcg gttgttcgcc gacgacaaca cgctcctccg
    15781 ggcacgccgg tttacctgga ccgtcctgct cggcgacggg acacgggcgt tggcgcgcgc
    15841 gggccgctgg gacgacgccg ttgcccacct ccaccgacac cacggcatcg gacgacggct
    15901 cctcgacggc cgccagaccc tcatactcgc gagccacctt gcaggagaat ccgaagccgc
    15961 acgcaccgcg ctcgccacca gtgtcactcc gacaccctgg gaacgagcgg tcgccgccgt
    16021 tctcggaatc ctctgccgac acggcagcga gccgcaggcg atcggagcgg cgctcgatga
    16081 cctccgcgcc agcagccgtg acccgaccca ccctgtattc cagaaccggc ttggcctaac
    16141 gctcctagac ctcgccaccg acgccaccga ccagaagtgg attgcgtccg cgatcctcgc
    16201 cggcctccgc gacggacacg acgggcggtg cgcggctgat gccctcgccc acccccggct
    16261 acaacagcac ctttcccccg cccatcgggt cgacctagtc gagcgagtca agaccgctgg
    16321 aatccagcga cctcccccga ccaccttccg tgacgcgatg acgacagcca cgctggccgc
    16381 ggaacgcgga ctccgcgacg cgctcgccgg gccattggaa ggcggccggt tgattacccg
    16441 ccgtcctgac cagagtgcag ctcgcggaga agcaggttga gcggggcgtg ctcgatgtct
    16501 ttatgctcgt accaggtgcg gaggagttct tccgctccgc ggagcatcgc gtccggcagt
    16561 ccgacggtcc ggtagctctc ggccgcttgg gcgagttcgg gtccccaccg ccaagcgcgg
    16621 gccgcgacag tggcgaagaa gtctggttcg gcgagcgccg gtcggcttcg tctgcgggcc
    16681 tcgtcggtga gcgcttgctg gacgccgtat tcggcggcca gtgcgtgcgc gagcgcggcg
    16741 agaacccgcg acgtcttcgc gaacgacgag tgggcgatct tcaaggcgga cgctgcgccc
    16801 acctggccgt cgaacacgat gacctgcacg gttgatccgg tgaacagccc ggagatctcg
    16861 ccggcgtggc gggcatcccc ggccaggtac atgcgtgtgg tgtcctgccg tgtcgggacc
    16921 gggccgatga ggcaagcatc aacgatggtg ccgcccgcag cggtcatgag ccgctcgatg
    16981 gcgcgcatac gttccgggtt gacggcattg gcgtctacgt acagacccgt aaaccccgcc
    17041 gcggccaccg cccgtgccac gtcaagcgcg gcctccggtg gacacaacga catcaggatc
    17101 tcggtgctgt cgcagaggtc gtccaggcgg ctgacgggca gcaggccggc atcctgggcc
    17161 cgttgcaacg tctgcgggct tcgtcccgtg gggcagtaca gcacctcgtg ccctgcggtc
    17221 cgcaagatct cgccgatccg cgcgcccatg ctccccgggt gtagcagccc aatccggcgg
    17281 ggcgtcacga gacctggtct ccttcatagc cggcggccga gggatttgct gccgtaggcc
    17341 gggaccgcac caccatctct gatctgatcg cgcagcccga cggcgagtgc ctgccctcgg
    17401 taggccggcc ggtcgagaat ggtcagcacc tgggtgaggc gtctcgcact ctcgacgcgc
    17461 cggaccgaca acatttcgat cacgatacgg accgcggaca tcgaggggac aatgcgccgt
    17521 caagtcagag cggttcggca ttgtgggcct gggcgatggc ctcgatgcgc cgtgcgagat
    17581 cgaagtcggc ggtggtgatc tgatgcccgg cgtcgtgggt ggtgatcccg aagcggatgc
    17641 tatcccagcg caggtcgatg tccgcatggt ggccgatcag ccgctcgacg tcggcaacgt
    17701 gcacgatcag ggcgactcca ccgtggtaac ggacgcggaa cgacttggtg atctcctggc
    17761 cagcacgggc ccagccggat agctcgcgca gctgcgcctc gatctcgtcg tcggccaggg
    17821 gcacgggagc gtccgccacg tcaggtctcc ttctccgggg cgaagatctc atcgatgtcg
    17881 cggccgacgg ccgcgccttt caagggttgc gccgcttgtc gtaggccggc gagctcgcgg
    17941 cgaatccgca cggacccagt ttccaccgcc agggccgccg caagtcgccc ggcatcgacc
    18001 gcgcgcccga cgtcgccgct ctggacgcac gcggtggcct gccgggcgag aaaaacaccg
    18061 cggtctcgcc gggcgttggc aggcgtcgtg tcgaggatct gccgccacag gccggcagcg
    18121 gccgtaacca ggcccaagcg tccgtagcag gtggcgcgtt gcacctccag gtaggccgac
    18181 gtgcgacggc atgcgttgcc ccacggcagg ccgtcgtcgc atctctcgac gagcggagcc
    18241 gcctggtcca gggcggagtc gacggtggcg cggtctccga cgagtgacgc gccgtgggcc
    18301 tgctgctgga gcgccaggac ccgcatcttc gggctgagtc gaccggcgtc ggccaggacc
    18361 gcgccacaca ggtcgagcgc gccgagcccg tcagcaagat ctgtgcggac tgatgcgtgg
    18421 ttgagcagcg cgtaggcgac gagctgcggg tcccgggagc gttgtgcgac ctccaaagcg
    18481 acgccccgcc agacggacga agtttcaagg tcaccggcat cctgatggag ccagccgatc
    18541 agcgaggcat aggccgcgct ggagcgcagg agggccagcc gcgtctcccc gcgtgcggtc
    18601 gccaccaggt tgctgatgag cgtgtgctga acggtgacgg tactgatcag ctcgcgggga
    18661 ccgagcatca cgtccgctcg gtagtggccc tccagctgct ggccgaagta gtcgacgagc
    18721 gccgggtcga cgtgccgcgg ggcggttctc ccgaacgtga gcgcggtagc cgtcgcggtg
    18781 acgaagtcgc gtcggtcgat gtgggccgga gagcctggct ggacgagccc ccgggcggaa
    18841 ggagcagccc ggggcgcagg cagaatgcgg ccagcggcag gctcgatgcg atcaacgcgg
    18901 ctgatcaaga gggtgtcggc gggagtgaag tgttcgcggt cgtcgaggtc gatgaggttg
    18961 tggatgttgg tgccgtagac ctcggcgagc agcgcgagga gctggggggt gggccggcgg
    19021 cggttgttgg ggagcggcca gttctccagc tcggacaggc gggggccgtc catcggggcg
    19081 gcgccacggg ggtcgaggcc gacctgggcg gcgtggctgt tgatgtgtcc ggcggcttgt
    19141 acttgggacc agccgtgcgc gtggcggtgc gcggcgcggg ggcggtagcc gtagcggcgg
    19201 gcgaactcga cggcgatttc gtcgtgggac atgccggccg cgcgcatccg cgcccgcagc
    19261 tcgtcctgtt ccgcccgccg gctggaccta ctcactccaa cgccccgcta tcttctccac
    19321 cagtgtgtcg gcggctttga acgtacgaaa aggattcgtg cacgccgcgg cgaatcgccg
    19381 tcacagccta cctcctttcg cggcgttgaa cgaatacccg gttctatttt atcgtgcgcc
    19441 atgcgctgac gcgatttcct gaatgcgcct ggcgagctcg atgtcgtgtt cggcgacgta
    19501 gccgccgatg tcgctggagc tgatcgacac atgcacggtc ttgtatccga gtgtcgcgtc
    19561 ggagtggtgg ccgaactcgt cctggatcgc ggcgatgtgc acgatgaacg cggcgccctg
    19621 gatgtggggt atcgagtaga gccgttcgat ccgccggccg tcggtcgtcc atccgtccag
    19681 ggtcttgagg tgttcgtcga tcatgtctcg ggtcagcgcc tcagccatgc tctctcccgg
    19741 tctcgtcggt ggtgaagggt gtgagcacgt cggcgagctc ctggccgagg gggtgcgcgc
    19801 gccacggagc catcgccgcc gcgaccgcgg ccagttctcg ccgggcccgc gcggagccgg
    19861 tctccaccgc gagcgcgctg gcctggcgcg tgaggtctac cgcccgctct ggttctccct
    19921 gccgcgcggc ggcgaccgcg tggcgcgctg accagacccc gacgtcccgg cgggcagagg
    19981 ccggggcagc ggggatgatc tgctgccaga ggcggtcagc gtcgtcggcg agacccagcc
    20041 gtccatagca ggttgcacgc tgcacttcga cgtagccgtc ggtgcggcgg caggccgtgc
    20101 cgtattcctc gacctcgacg tgctccacga gccggccggc ctgatcgagg aggagatcaa
    20161 cctggcgacg gtcaccgcgc agcgacgcgc cgtgtgcctg ctgctgcaag gcgaacacct
    20221 ggacttcggg tgccagctgc cgggcgtcac ccagcgcggc ctggcacagg tcgatcacgg
    20281 ccgccgcgtt tcccaggtcg gtgaaggcca tcgcccgatc gaccagcgcg caggcgacgg
    20341 cgtcgcgttc cccgcagcgg tgggccagtt ccaaggccgc gtcgtggcag cgcatcgcgg
    20401 cgaccgcgtc tcccgcgtcg agccacagcc aggccgcgaa cgcggcgaac gaggagccga
    20461 ccttcgccag gccccggcgg gtcgacccgt ccgcggcatc cagcagttgc gtgatgacct
    20521 cgtattggga ggcgaccgtg ccgatcaggg cgccggcgcc gagcagcatg tccgcgtggt
    20581 agtggccctg gagctggccg tcgaagtagg agatgagcgc cgggtcgacg tggcgggcgc
    20641 ggccggcgcc ggccagaccc gccactactg ctgatcccgc gagaagagtg aacccgcggc
    20701 ggccgagagc gtccacccac tccatgcttc cagcaggccc gtcgagacgc agccccctgg
    20761 ccgcaccatg accgcgtccc gactggacgc acggggccgt ggggctgaaa cacggggccg
    20821 cgggcagtgc aaggttcacc ggtgatcccg tcggcggcgt tggccgagcg tcctggcgtg
    20881 tggtggtgat gaccagcatg tctgctgggg gcatgtgttc gcggtcgtcg aggtcgatga
    20941 ggttgtggat gttggtgccg tagacctcgg cgagcagcgc gaggagctgg ggggtgggcc
    21001 ggcggcggtt gttggggagc ggccagttct ccagctcgga caggcggggg ccgtccatcg
    21061 gggcggcgcc acgggggtcg aggccgacct gggcggcgtg gctgttgatg tgtccggcgg
    21121 cttgtacttg ggaccagccg tgcgcgtggc ggtgcgcggc gcgggggcgg tagccgtagc
    21181 ggcgggcgaa ctcgacggcg atttcgtcgt gggacatgcc ggccgcgcgc atccgcgccc
    21241 gcagctcgtc ctgttccgcc cgccggctgg acctactcat gctttctccg cggacctgtc
    21301 cggtccccga gcacgtcctc cgccggcatt tcggggcaaa caggtgccgc gccgcctgct
    21361 cggcctccac cgtcgcggtc ggtgctgtcg gttgccgagg tgagcaccag gcttctcctc
    21421 cgctcggccg gcgggtgacg gtctgtcaac cctacgacgt cgtggatcta tccggcgtcg
    21481 atggatcagt aggggcacgg cgcgcacagc acgaagatca agccgggcgc ggcgctccac
    21541 caggatgccc ggcgtcatga gcggagacat tcccctcgtc gcgaaccttt tcttcggctg
    21601 ctatgaagcc gctgatctgc ggaaacgacg tgcggcagtg cgatttgttc ggcgccacac
    21661 gggccaagag ttcgcggacc tctatcgagc cggccgggtg cttgtggcaa ccgactcgtg
    21721 ggggctggca ccgcaacagc gcacatagat gatcatggcg gcgatgtcga cgcgggtacg
    21781 ggcctcgtcc aagcccaggc cgagccgtgc ggcccggtca tagtcgtcca aggccgagca
    21841 caggtcggcc cagtcggggt ccgtcgggtc gagcggtggg gtgaaggtgg cgagcagact
    21901 cgccagtttt tcggggggca ggagttcgcg catacgcgcg agcagaacga tgggacggag
    21961 cgcgggcggg actgtgtgtc ggtgagatcg catggaggtg gcttcgttgt tggcggtccg
    22021 ggtcggcgtg gagccgcctc accgccggcc gcgacggaat cgcggccggg acccggaccg
    22081 gggaggggaa aacgaggaga agctgccgac catctgtcca tcggtgctga tgagggccac
    22141 gtagccgtcg aagcgcagtc cccaggcgac gacgtggata tcgccgtagg agggttcggc
    22201 gacgatcgcg aacagacggg gcgccaggac gtgcacgagc gcactgagca aacccacgtc
    22261 ggcctgaccc ggcaggtcgg cgtcgacgat ggcggggctg tcggtgtggg gatagtcgac
    22321 ggtcacggtt gttctccggc cggtggtctg ggtaccgccc cttgtttcga gggcgggtgt
    22381 gctggagcgt cgcgggccgc ggtgacggcc cggctgaggg cggtggcgag agcgtcggct
    22441 tcgtcgaggg tgagggcctc gctgtcgggg tcgtcgtccc cgacagcgag ggagatcagg
    22501 gggtcgtaga tggtcgtgga ggtcacgtac tgttcgatgg ccacctggac ggcggtgccc
    22561 tcgcgtatcc cggcgatctc tggcaggtcg atcacgatga acgcggagat gtggtagtcg
    22621 ccggggcctg ccggctctac ctggaggtgg ccggttggct ggtcgcacca cggtgggcag
    22681 gcggcgtcca caggctcgct cacggggtcg tcacctgttc gccgtcgcgt gggtcgcccg
    22741 agtttgtgat cgtcgtccag tcgtcgccca ggttgcgcag ggcgtcgagg acgcgttgca
    22801 gcagcgcgtg gtcgaagatg tccgcatccg gtccgccgtc gctggtgggg ggcggcgggt
    22861 cacggcgcgg cagatcctcg gccggcttgt ccggaaggtg ctggatgggt ggcaggtcgt
    22921 gggcgagcgc cgcccagacg atctttcctt tggtgcggta gccgtcgggg gtgcggacgc
    22981 ggactgggta gtagccgaga tcgcgggcga gcgcggcgac gagaggcaga cccctgccgt
    23041 tttcggcgtc gggcccggcg gtccggcggg ttgggcggcc tgggccgcca tcccacacct
    23101 ccacgatcag gtcgcggtgg ctgtaggtca ggcgcatccc gatccgggac ctggtgtcct
    23161 gctcaccgtg gggacggcgt gcctcgtggg aggcggcgta ggcgttggtg atcaattctg
    23221 atgtcacgca ggtcgcggag tcgatcaggc tgtcgaggcc ccagcggcgc agctgtgccg
    23281 cgacatcgtg gcgggcgggt ctgacggact gtgggcgggc cgggtagtgc cggatgtact
    23341 gcggcagcgg ctcggcaggc tgctcaggcg tggtggacgg ggttatggcg agcacggtgg
    23401 tcatacggat tctcctgaca cggaggcgga aagcggccct cgcgctgacg ctgcgggtgc
    23461 ggccgggggt gtagggccac tgccagccgc cctggacgcg acaggctggg ccggagagac
    23521 cacgtgatcc ccggccgtgt cggcgggagc ggtcgggcgg tcgggcgggg aatccggggc
    23581 acgggcaggg gcggtgtcgg cgaccagcgt caggttctgg tctgcgagca ggaccaggtc
    23641 gcacggccat ggccgcccgc agcccgcgca gacggcgccg tgacggacgt gggtatcgag
    23701 caggcggacc gcggcgcctc gaagccgctc gaagtcacga tcgagcgggt cgtgaccctc
    23761 gttgtgcggt gaccggctca ccggggcgcg gtgcagcgtc gtgaccatga aggttcgcct
    23821 tccgtgggcg gggtccgcga cggtgcattc agcgccgcgc ggtcgtcgtg gccctctcga
    23881 cgtcgtcgtc gtccgccggg cggccggcga gcgcggccag ggtggcgttc agcgcgggca
    23941 gagcgcctcg ccggcgcagc tcaccggtga gggtcttgac gtcggccagc gccggcagcg
    24001 gacgagccgc cagctggccg atggccgggt cgaggggcag cgcggcgggc agtgtcaggg
    24061 cggcgacgac cgtgtcgtag acggtggccg cccaggtcgt catcacgagg gtcagccagc
    24121 cgttccactc ggcgccatgg gcggccaccc ggccagcaag gtacgcctcg ataccctcga
    24181 cgaagtccga ccgcaccgtc ggtgggctgt cgagggccag cagatgcagg tggccaagca
    24241 gggttccgat gtccgcgggc tctccccccg gccccaggtc aggggacacc agcaccgggc
    24301 gggacgaggt ttccgggtac agcacgtggc gtggtgtgag cccgccgaac gcgatcccgg
    24361 ttcgggtgac cagcaacgga tcgagctggg cggccagccg cgtgagccgt agggacaggg
    24421 ttcccagcag cgcgcccagc tcgccggtcc cggctggctg cgcgggagct gaatgaaggt
    24481 gattcaccga gtgggccaat gcctgggcga gaatccgagg gtgcgttcgc agggtcgtcg
    24541 gcgcggccac ctgccgcagc tgctccggtg ggtcgcggtg cagttcaccc aggtcgtcca
    24601 tgagcgtcgt cagcaggtgc gtgagggccg ccgggcggtc ctggagcctg ctggtcaggc
    24661 tggcgccggt cacccacggg gcgaacatca ccccgcgtac cgtggcgatc gggccggcga
    24721 cccgcagacc gctgtaggcg acgagggcgg tgagctgttc ggcttcccgg gcggtcgcgt
    24781 cctcctgggc cgtcgcgtcc gcgtcgcccg cctcgtcgct cagcacggcg gcgaggtcgc
    24841 cgcagtcgcc gagcaccacg ccagtgagcg gtgtgcccgc ggggcgcagc gtcgcgcaca
    24901 gcgtctcggg accgacgtgc acctggcgca ggatcgcgct gccagccgtg agcgtcggtc
    24961 cgaacgtcgt ctcggtccgc ggccacagcg cggcggtcgc ggcggcgatc cgtccctcgg
    25021 cgtgctccac cagccggcgg acgtcggccg caggccagca ggtcgagcag cccggcggcg
    25081 ggctcatcgg atacgaccga cgccggcgta gaccggcagc cgtccggcgg ccgtcgtcgc
    25141 ccggcgctgc cggtcgtcct cccagcccgg gagcaggacc acgccgggct cgaccagctc
    25201 ggtgccgtcg aagaaccccg tcacctggtc ccggtcgcgc agctggaacg gcgcggtcgt
    25261 gcgccggtac acctcggccg cgtccgcgac gtccctgccc tgcccgtc
//
