LOCUS       NC_006582              24508 bp    DNA     circular CON 16-JUN-2024
DEFINITION  Shouchella clausii KSM-K16, complete sequence.
ACCESSION   NC_006582
VERSION     NC_006582.1
KEYWORDS    RefSeq.
SOURCE      Shouchella clausii KSM-K16
  ORGANISM  Shouchella clausii KSM-K16
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Shouchella.
REFERENCE   1
  AUTHORS   Kageyama,Y., Takaki,Y., Shimamura,S., Nishi,S., Nogi,Y.,
            Uchimura,K., Kobayashi,T., Hitomi,J., Ozaki,K., Kawai,S., Ito,S. and
            Horikoshi,K.
  TITLE     Intragenomic diversity of the V1 regions of 16S rRNA genes in
            high-alkaline protease-producing Bacillus clausii spp
  JOURNAL   Extremophiles 11 (4), 597-603 (2007)
   PUBMED   17429572
REFERENCE   2
  AUTHORS   Shirai,T., Suzuki,A., Yamane,T., Ashida,T., Kobayashi,T., Hitomi,J.
            and Ito,S.
  TITLE     High-resolution crystal structure of M-protease: phylogeny aided
            analysis of the high-alkaline adaptation mechanism
  JOURNAL   Protein Eng 10 (6), 627-634 (1997)
   PUBMED   9278275
REFERENCE   3
  AUTHORS   Kobayashi,T., Hakamada,Y., Adachi,S., Hitomi,J., Yoshimatsu,T.,
            Koike,K., Kawai,S. and Ito,S.
  TITLE     Purification and properties of an alkaline protease from
            alkalophilic Bacillus sp. KSM-K16
  JOURNAL   Appl Microbiol Biotechnol 43 (3), 473-481 (1995)
   PUBMED   7632397
REFERENCE   4
  AUTHORS   Hakamada,Y., Kobayashi,T., Hitomi,J., Kawai,S. and Ito,S.
  TITLE     Molecular cloning and nucleotide sequence of the gene for an
            alkaline protease from the alkalophilic Bacillus sp. KSM-K16
  JOURNAL   J. Ferment. Bioeng. 78, 105-108 (1994)
REFERENCE   5
  AUTHORS   Takaki,Y., Kageyama,Y., Shimamura,S., Suzuki,H., Nishi,S.,
            Hatada,Y., Kawai,S., Ito,S. and Horikoshi,K.
  TITLE     The complete genome sequence of the alkaliphilic Bacillus clausii
            KSM-K16
  JOURNAL   Unpublished
REFERENCE   6  (bases 1 to 4303871)
  AUTHORS   Takaki,Y., Kageyama,Y., Shimamura,S., Suzuki,H., Nishi,S.,
            Hatada,Y., Kawai,S., Ito,S. and Horikoshi,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2003) Contact:Yasushi Kageyama Kao Corporation,
            Biological Science Laboratories; 2606 Akabane, Ichikai-machi,
            Haga-gun, Tochigi 321-3497, Japan URL :http://www.kao.co.jp/e/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000009825.1-RS_2024_06_16
            Annotation Date                   :: 06/16/2024 13:26:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,355
            CDSs (total)                      :: 4,253
            Genes (coding)                    :: 4,204
            CDSs (with protein)               :: 4,204
            Genes (RNA)                       :: 102
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 25 of 49
            Pseudo Genes (incomplete)         :: 37 of 49
            Pseudo Genes (internal stop)      :: 14 of 49
            Pseudo Genes (multiple problems)  :: 21 of 49
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:31:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3691646
            Orig. end                         :: 3716154
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP006627.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24508
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24508
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24508
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14508](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14508)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(235..1218)
                     /locus_tag="ABC_RS18380"
                     /old_locus_tag="ABC3549"
     CDS             complement(235..1218)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010899852.1"
                     /locus_tag="ABC_RS18380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3549"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_011248387.1"
                     /transl_table=11
                     /translation="MTTIKDVAKYAKVSVATVSRVLNQKGYVSKEAEQAVKTAIETLNY
                     KPNAVARTLYHKTSGMIGLLVPDIANPFFPELARAIEDVALKKGYTVVLCNTDNELKKE
                     QHYVHALQQKYVDGLILATGTGTYEHYETLDLPVVALDRFVSANIPTVVSENKNGAKAA
                     TEHLIEQGCAFIAHLRGPKGLNPADERYEGFKEVVEANGIAHIIVETGFQIEQAEEAVR
                     ALLEKHPTIDGIFTSSDVAAAGAMKAAHTLKRSIPEDLQIVGFDGILFGNMLVPSLTTV
                     QQPIYEMGELAIQLLVQLIEKRSLQSYWHELPTTLTIRGTTKGGGA"
     gene            complement(1745..2698)
                     /locus_tag="ABC_RS18385"
                     /old_locus_tag="ABC3550"
     CDS             complement(1745..2698)
                     /EC_number="3.2.2.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010530225.1"
                     /locus_tag="ABC_RS18385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3550"
                     /product="nucleoside hydrolase"
                     /protein_id="WP_011248388.1"
                     /transl_table=11
                     /translation="MANKLLVFADTGIDDAMAIIYALQHPDVELAGIVGDFGNVIRDQA
                     LRNASYLLSLADRKGVPVIAGATRALNGEEPEFFPDIHGEEGLGPIRPPIPAERYANRT
                     NFSRLFQVIKENPNEITIVVLGRCTTLAMAWMINPAVMKRVKATFLMGGAFLVPGNETE
                     LAEANFLGDATAANFVCTHAPNVTIVPLNVTRDALLTPADVNLINSKATTPLLRTIKPM
                     LDFYYESYQVLEPGIQGTPQHDLTALMAAIDVPNLLDYKRRNVQIEDQGRYSSGLSIAD
                     FRPASGACSGPYCPRIAVRLDFSVFRTNVLDIFTRS"
     misc_feature    3236..3250
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.62"
                     /tool="antismash"
     gene            complement(3249..3383)
                     /locus_tag="ABC_RS22955"
     CDS             complement(3249..3383)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ABC_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255222650.1"
                     /transl_table=11
                     /translation="MTILILIVLLGFLVDFWKARQQRNEIIKQNKEMIALLKELTTKK"
     misc_feature    complement(3444..3462)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.69"
                     /tool="antismash"
     gene            3992..4834
                     /locus_tag="ABC_RS18390"
                     /old_locus_tag="ABC3551"
     CDS             3992..4834
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024245.4"
                     /locus_tag="ABC_RS18390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3551"
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="WP_011248389.1"
                     /transl_table=11
                     /translation="MNTLFLLFLLLTFFGLILGLIKPALVRFPTRKRVFAYGIPAFIIT
                     AFLFGNTLPAETAQSAQLDRSQAKIETLEASLQDKETEMEELTVALEEAEESLKESEEQ
                     LELLQAEEGDVDGSFEEQLEEAKLEWEEEFREQIEEELEERITAEISEDYEDKLAALDD
                     KIKEKEQTIEEKETTISKLEEEVASASTNNGNETATTETETAQSSESASTDSCGPGTVK
                     INSASESELQAIYEIGPDRAAQIIQLRPFSSYNDMKRIKGIGDARAEAIENQGIVCFD"
     gene            complement(4869..6293)
                     /locus_tag="ABC_RS18395"
                     /old_locus_tag="ABC3552"
     CDS             complement(4869..6293)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="ABC_RS18395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3552"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_011248390.1"
                     /transl_table=11
                     /translation="MNKKRTSIKQQIRLTIAKTILLSFFATIIVVLASWAIVMSIDDRY
                     YANYYESQVPQITDQVQSLNRELVNSQASGAKQLEEIIPTPGMEYQVLDEQGTFLYGSF
                     SANVNPEGVHLLNKVNKSFLEENTATSFIPIVDQNGTFAGSVVLQYKLESEVEALFNIF
                     FVCLFLTPFFFIMIFTYYYASKLGKNYYARIQKLIVATELVRKQNLDFEIEADGNDEIT
                     KLSTSFNIMKQALQDALYQQWNLEKNRSEFISSVSHDLKTPLTIMKANAQMLERKIKDE
                     QHKTYIANMIGEIERTEKLVQELGTKMNDEESFFAIETKTVEPGHFFKTEFAKYKDFVQ
                     NEGLTFHTSVLDYRKTANTIQIDVQKITQVIDNLISNSLRFAEPYDGHIDCHAECHDDY
                     VKVTVSDNGKGFTESDLHYVFQKFYQNNDSADPHKGLGLYIVKHIIEKHGGNVQAWNDK
                     GAVVSFQLPAIPKNSH"
     gene            complement(6286..6960)
                     /locus_tag="ABC_RS18400"
                     /old_locus_tag="ABC3553"
     CDS             complement(6286..6960)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="ABC_RS18400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3553"
                     /product="response regulator transcription factor"
                     /protein_id="WP_011248391.1"
                     /transl_table=11
                     /translation="MEHILIVDDEIQITSIVGELLQEEGYQTTVANDGMNAIKLIKEQD
                     FDLIILDIMMPYVNGLDVCRSVREFTDVPILFVTARTSMNDQINGLNIGGDDYINKPFT
                     HEQLLARIKTHLRREKRKQQPTDELVYGKIKLDRRTNELRYGETPLLLTNKEFKIMEML
                     MSNPRQIFSKDHLYETIWGVEATGQSHTVTEHIRNIRIRIHKIDPMANLIHTVWGVGYK
                     LE"
     gene            complement(6981..7748)
                     /locus_tag="ABC_RS18405"
                     /old_locus_tag="ABC3554"
     CDS             complement(6981..7748)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ABC_RS18405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ABC3554"
                     /product="ABC transporter permease"
                     /protein_id="WP_011248392.1"
                     /transl_table=11
                     /translation="MKHLIISELERLWKMRMMKILLLLLVGISFFSAYFLTWFDLGLYT
                     ADSETPLNAVNFPWFLLREVSFFVTLVIMPLFCVVVLNSPIKAKTYNLVLYRPFHRLEF
                     LLSKWGTLLLIAVFITVFIWLIGVMLGFFFYQVPEYVTFYGDLTRYSILNGYIYSAKLY
                     FLFWAVIAAGIAIASVMSIMAPNPIIAYFLLMIAYVVPIYFSNELTFLLMPTQSIFISL
                     SETNMPLLYMALPLIVLFGGGISSLLWVKQDFK"
     gene            complement(7761..8585)
                     /locus_tag="ABC_RS18410"
                     /old_locus_tag="ABC3555"
     CDS             complement(7761..8585)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="ABC_RS18410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3555"
                     /product="ABC transporter permease"
                     /protein_id="WP_011248393.1"
                     /transl_table=11
                     /translation="MGQLIISEFERLWSRWSIRLLVMTLPLLVIVTGVYFKNHNRNRSM
                     DTVDYATALNFPILSISEHLFITFNILLIFICAYVITEEYQQKQIKLIVLRAYSMSQIF
                     LSKFIVMATSLFICFFLYYLASFFAGQIMFEMPERSILFVSEADVTNTEMVLYGLNYYG
                     IAFLTSLAALSLFCFIAILMPSVNALLGSGICILFFSIVGPQLLEQSTAFAEGSNISYV
                     VYASITKIQYTGISLLLSGGELSGWLIAVTSFYLLVFLGGAYLVFTRRNYYV"
     gene            complement(8585..9307)
                     /locus_tag="ABC_RS18415"
                     /old_locus_tag="ABC3556"
     CDS             complement(8585..9307)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058380.1"
                     /locus_tag="ABC_RS18415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3556"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_011248394.1"
                     /transl_table=11
                     /translation="MEKIIETKNLTKKIKGKPLVEEINLSIAKGEICGLIGPNGAGKTT
                     IMKLLTGLLIPTSGEVKLNQWNVHKQRKEAMRSVGAIIESPIFFEFMTGRGMLLNLARL
                     HGLNKQERQDKVAEALTIVGLDGRGDEKIRTYSLGMKQRLGIAQALLGNPEIVILDEPA
                     NGLDPMGMRELRELILQLNKEKNITFLISSHLLDELQKICSTLVIIKQGNVLFYGKQEE
                     IYDKTENNLEDIFIGMMT"
     gene            complement(9418..9990)
                     /locus_tag="ABC_RS18420"
                     /old_locus_tag="ABC3557"
     CDS             complement(9418..9990)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.4"
                     /locus_tag="ABC_RS18420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3557"
                     /product="flavoprotein"
                     /protein_id="WP_011248395.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.4e-29, bitscore:
                     99.8, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEKEEKNILVGISGSISVINMPSYLAFFKHTYGHVKVIITEQAN
                     KLFPASSLSLFCDDIFQDHNETIDPNTSSHVGLARWADLFIVLPATANKIGQVANGLGM
                     DLLSSTILASTKPVLFCPNMNEAMWNNFFVKRNIALIKEGGHIIIPPVEKEAYEVASGS
                     IRKNFIIPDMYTIAQEIDKAMAVEEKS"
     gene            complement(10001..11347)
                     /locus_tag="ABC_RS18425"
                     /old_locus_tag="ABC3558"
     CDS             complement(10001..11347)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="ABC_RS18425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3558"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_011248396.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-84, bitscore:
                     282.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEKVVDDQEKQETKRIIARLTEKLNDPQKVEEIVMDKNNVTTIS
                     KVNPWDPVSLSHGFAGTILFFSELHKMYPEEKWDHVAHNHIVYASNYLKNGVHSISLFG
                     GITGFAFAVFNASENGTRYQNLLAKLDEVIRRVAENEIEEEKQRNGLGALPTFYDVIQG
                     YSGIGRYLLERRKDTPAFNGLIEAILRQFVEMTATITWEEHEVPGWYVTQENQFLEKDK
                     KIYPFGNFNLGLAHGIPGPLSFLSLCLLKGIEIPGQRQAITTIGNWLVRHAKSNSTGAP
                     VWAHRVGVKEAIANKYTVIDEREGWCYGNPGVARSLYLAGKALNELPYQEMAVKCFHGI
                     KEKTLEELDLQSATFCHGKSGLLQIMVRMKNDLNINDFDKLINQLENGIKEQYRDQHPL
                     GFKDFEIGSRTNELDKAGLLEGAAGVGLALLSRTGDDSDLFWDKAFLIS"
     gene            complement(11359..14508)
                     /locus_tag="ABC_RS18430"
                     /old_locus_tag="ABC3559"
     CDS             complement(11359..14508)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="ABC_RS18430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3559"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_011248397.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-188,
                     bitscore: 625.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-14,
                     bitscore: 52.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-36, bitscore:
                     124.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKSEQLLYEPVDTIMLRAPILSLSHDHQNASKDDIIPILKEYIE
                     RPEIKEALAVASPNLFQSLDKIHGDPRSKKTRNAVSSLLKFLIRMSSRPTPFGLFSGIA
                     IGELGNKTVGSLLDTKQHQKRARPDMEWLLGVVSKIEKNQTIAKKLNVVFNDAVYQTDD
                     RVYLHYFSNCGQLRSSENQERKDNISIRKTVVVEFVQSVAKKPISISELINQLQLTYTS
                     ASINEIESFVWNLFQQEFLISELRPPIVNCAPLSYVIQILESIPEATEIGAMLKGIEAD
                     IETYNQLPIGQGLDFFQTLTAKMQDIHPSKQPLQVDLRLTCAEKVRINRSIGEQVANAA
                     EWLWRLSKNETGVAHLREYHVEFLEKYGVNREIPLLDLLSDEKGLGAPPTYKYPPSAKS
                     VNPPQMKSTHRLLMEKYIQCLRENAKEITLTESDLQKLMDNDTDDVFAPNSGELFVEVL
                     ASSAEEVDKGNYQLAIGTNVGSQELGQTFGRFSDMIASEENRNLMEEQKKIEETCTDVE
                     TEYVELSFLPQSGRASNVSITHSTRNLHTTIATNANGQNKKLLLEDILVGATLGRFYLK
                     SKKSNKRLVFTSNNMFNYESAPNCFRFLREVSLEDGKAIQGVNLGSLREFTFIPRITSG
                     KVILSPAIWKLNDQIEELSDFSMPLEEWIEQFSTWMKKMQVPEQVFMAYGDNRLYIHLK
                     NANHMQELRSELRRRGRVQLQEIIGGYREKQWVKSPLGRHNAEFIVPFKKRPHVPAKPT
                     VMIKPVAEVPIECREKEPGTDWLYFKLYGPIHKQQKLISTQIPTLVAELENHKLINSWF
                     FIRYYDSEPHLRLRFHGDPKTLLAGALPVFQKWYAAQRLAGNVKKVVIEPYEREIERYG
                     GLSLMPLMERYFEKDSLLTSNLLGLSSKQALKEPLELIASMYVVYFLTEYGWHHERQLE
                     WISKWSEDPAYSKEFRPYRNDVLKWLDQEENWKALKEQKGFLFKLFSKNEAIIHELSHN
                     MEITPMTNTEERVVGSLIHMHCNRLLGTDRDREKKAMAFVRQIIESQKHWNKTKGRPLN
                     V"
     aSDomain        complement(13765..14052)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_ABC_RS18430_Lanthipeptide_LanB_RRE.1"
                     /evalue="7.60E-17"
                     /identifier="RREFam001.1"
                     /label="ABC_RS18430"
                     /locus_tag="ABC_RS18430"
                     /protein_end="248"
                     /protein_start="152"
                     /score="52.8"
                     /tool="antismash"
                     /translation="VFNDAVYQTDDRVYLHYFSNCGQLRSSENQERKDNISIRKTVVVE
                     FVQSVAKKPISISELINQLQLTYTSASINEIESFVWNLFQQEFLISELRPP"
     gene            complement(14638..14772)
                     /locus_tag="ABC_RS22115"
     CDS             complement(14638..14772)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="ABC_RS22115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_073304601.1"
                     /sec_met_domain="TIGR03731 (E-value: 4.7e-17, bitscore:
                     59.7, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 2.5e-09, bitscore:
                     34.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKAFDLDLEVVHTKAKDVQPDFTSVSFCTPGCGETGSFNSFCC"
     CDS_motif       complement(14707..14772)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKAFDLDLEVVHTKAKDVQPD"
                     /locus_tag="ABC_RS22115_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14638..14706)
                     /prepeptide="core"
                     /locus_tag="ABC_RS22115_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="8.10"
                     /molecular_weight="2109.4"
                     /monoisotopic_mass="2107.9"
                     /core_sequence="FTSVSFCTPGCGETGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKAFDLDLEVVHTKAKDVQPD"
                     /leader_location="[14706:14772](-)"
                     /alternative_weights="2127.4"
                     /alternative_weights="2145.4"
                     /alternative_weights="2163.4"
     misc_feature    14882..14896
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     misc_feature    14905..14914
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    14956..14965
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(14989..15002)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.04"
                     /tool="antismash"
     gene            15120..16031
                     /locus_tag="ABC_RS18435"
                     /old_locus_tag="ABC3560"
     CDS             15120..16031
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF037898.4"
                     /locus_tag="ABC_RS18435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3560"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_011248398.1"
                     /transl_table=11
                     /translation="MDNRIGMEIRNLRMKLGMSQENISSSVVSQSAISKIENGKYIPNI
                     IVLEAIASKLGVPVDHFLTLSTSYNGEYIETTYEMIEQLSLHEEYEELNRLTAQLIDCG
                     QAVEFPNWFKDYIRIHHLFSEYQCRKKDAQTTWMKLKCMAGCLPFEQSIQTKFHLYLGI
                     IHSHMKTYSYSETLDYLQKSLASVEGIKGKNTYLHKKNLKIYILYQKTIIELNYHHYDA
                     ALKDIGQGLQLSRNYACTAYVGQFLYYKGLCLEKKGVPFKNILKHYEEAHFFASFTNNL
                     PFKKLLSDKLSARKEESYGVYN"
     gene            16015..17799
                     /locus_tag="ABC_RS18440"
                     /old_locus_tag="ABC3561"
     CDS             16015..17799
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017434401.1"
                     /locus_tag="ABC_RS18440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3561"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_011248399.1"
                     /transl_table=11
                     /translation="MGSTTERPIQLKEFISLMRLYRPSLWLLGLALFLVLMETALSLAV
                     PLLTMNLVDITVESNFSGTTAALIAGVFIVQIILSGISMYMMIYIGQIMVAKLRKDLWH
                     KVLRLPVSFYDRNSSGETMSRITHDTNVIKNFFTDQLIPFLSGTIKIIGSIMILFALNW
                     SITLLLLLIVPVSLAALKPLGRKTYKVSKALQDETASFQGDLGRVLSDIRLVKSSIAED
                     PETSQGNNRIDQLLKHGLDTGKIMAIISPLMTTITLLVLVVVFGYGGIQVANGTLSAGT
                     LVAIVFYMFQIIPPISQMGHFFTQLQKAKGATERITYIMEENLESQLAASVSYPHNQET
                     VARVNGIRFSNVSFSYPNGSQILKNVSFSANASEVTAIVGPSGAGKTTLFSLIERFYPP
                     SEGSIEYDNQPINDFDVQEWRQKIAYVAQDSPLMAGTIRYNLTYGHAEKSSDADIHAAL
                     EKANLTSFITSLPDGLETEVGERGILVSGGQRQRLAIARAILRNPQILLLDEATAHLDS
                     HSEFLVQEALNQLMLSRTTLVIAHRLSTVQHADKLVVVQSGEITGEGTHDELIEHHQFY
                     RELVDRQLYKKESPELIN"
     gene            17839..18063
                     /locus_tag="ABC_RS18445"
     CDS             17839..18063
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ABC_RS18445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_035203448.1"
                     /transl_table=11
                     /translation="MIAIILFCLNVILYYVSTLFQFEPTYTIGLWTFLSIVGVLFAFKA
                     AKPSVKIIGLVLNGAFLLFSLLLIIALFL"
     gene            complement(18948..19202)
                     /locus_tag="ABC_RS18450"
     CDS             complement(18948..19202)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ABC_RS18450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_041824137.1"
                     /transl_table=11
                     /translation="MADIPYSVCSCLYTGIQKSIAFLTMQANAVEASKECVWKRYDDQL
                     YHEVKEALQWHRQHCMADTSHLEEALRVFENAYNQVHDK"
     misc_feature    complement(19233..19247)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.59"
                     /tool="antismash"
     misc_feature    complement(19327..19341)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.21"
                     /tool="antismash"
     gene            19480..19818
                     /locus_tag="ABC_RS18455"
                     /old_locus_tag="ABC3563"
     CDS             19480..19818
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011247969.1"
                     /locus_tag="ABC_RS18455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3563"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_011248401.1"
                     /transl_table=11
                     /translation="MAELNDRLRELRKAHQLTQQEVASFLGITESAYGFYEQGRNEPSI
                     AKLKQLAEKYNVSIAYIAGETDIKTAPSDKVKENGSAYTFTNLDEEEKEFLGEQLELFR
                     RLKKKKGH"
     gene            19945..20076
                     /locus_tag="ABC_RS22960"
                     /old_locus_tag="ABC3564"
     CDS             19945..20076
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ABC_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ABC3564"
                     /product="hypothetical protein"
                     /protein_id="WP_011248402.1"
                     /transl_table=11
                     /translation="MDQFSIGTALYQIFAIVFLFGFFGLGGYFLILGIRYFKRELKK"
     gene            complement(20126..20716)
                     /locus_tag="ABC_RS18460"
                     /old_locus_tag="ABC3565"
     CDS             complement(20126..20716)
                     /EC_number="3.4.22.70"
                     /GO_function="GO:0004197 - cysteine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016485 - protein processing [Evidence
                     IEA]"
                     /GO_process="GO:0045184 - establishment of protein
                     localization [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017358814.1"
                     /locus_tag="ABC_RS18460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3565"
                     /product="sortase"
                     /protein_id="WP_011248403.1"
                     /transl_table=11
                     /translation="MRKRTLFIGMLLIIAGLALVAVPLTKEWQQANGVAQLEKALAAVQ
                     TGETIEKTDDSPSSWTKEQLEAVMELEIPAIDLKQYILDETTDENLALTLTQIKQEQVP
                     GEGNFAVAGHRGYRGDRHFRQLPNVQKGDEIRLHADDGKTYIYVVKSTEIIEPTDVDVL
                     NDGEQPEITLITCTLSGQQRVAVKGDLIDVIEA"
     gene            complement(20733..22160)
                     /locus_tag="ABC_RS18465"
                     /old_locus_tag="ABC3566"
     CDS             complement(20733..22160)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037639.4"
                     /locus_tag="ABC_RS18465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3566"
                     /product="SpaA isopeptide-forming pilin-related protein"
                     /protein_id="WP_011248404.1"
                     /transl_table=11
                     /translation="MEKVDAADQQLLLAGAVFSLLDEAGNVLEENLMTDQHGRLEINNL
                     PPGDYQLVETKAPEHYQLDATPIVFTIEKGQTVTPVITVENTLIPGAAALIKVDQDNGD
                     IRLAGAEFMLTDADGNVVAEQLVTDENGLVAVSDLVPGTYYFVETKAPLHYERDAEPVA
                     VTVEKGQTEAAVVKKSNTLIPGAVVLEKVDSSDHSTLLAGAEFRLEDEQGTVIQEKLVT
                     DETGRIIVTDLKPGNYQFVETKAPNGYDLNEEGLAFTIERSQEAAVVVKAENTLTPGSV
                     EIVKVDSSDGARLEGAVFTVLTEDGDMVAEGLTTDESGSVQLDGLAPGTYQLVETKAPA
                     HYQLNETPIAFEISKGQTERLVLTVENTLIPPGEEPKEPQPPSEPKQPPTEPGDGQTPT
                     GPQNNNGGTGTGKTGTPKAGGGDPSPLLSKGAQPASGGQLPQTGETEMFMFMVAGLLLM
                     AIGALTLVNGRLARKRG"
     misc_feature    22201..22214
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.14"
                     /tool="antismash"
     gene            <22471..22770
                     /locus_tag="ABC_RS23125"
                     /pseudo=""
     CDS             <22471..22770
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611148.1"
                     /locus_tag="ABC_RS23125"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DDE-type integrase/transposase/recombinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="PNQKLVTDITYVSVGEEFYYVSVIQDLFNNEIVSWELSKRNDNSS
                     CIQRFSFSTLITLLIFSSEVLVRKTCTSDDNDLKRRFVRREILEPFSFPLIFPF"
     gene            complement(23001..23870)
                     /locus_tag="ABC_RS18470"
                     /old_locus_tag="ABC3568"
     CDS             complement(23001..23870)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011248037.1"
                     /locus_tag="ABC_RS18470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABC3568"
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="WP_011248406.1"
                     /transl_table=11
                     /translation="MGLQSTTPMLKKAKANKHGIVAFNVHSFDSIFWVLEAAAELKSPV
                     ILQTTVGTVKSLGAKNIAEVAKAAAEHYQVPTGLHLDHCTDFEVIKDAIRAGYTSVMMD
                     ASMHPFAENVARTKEVVALASSLGVNVEAELGKVGGVEDDIVVDEADAQKAIPEECRQF
                     VEETDVPTLAPAIGTAHGIYKGKPEIDFERIAKIAEMVDVPLVLHGGSAVPEEDVRRCV
                     ALGMAKVNVSTELKNAYSEAIRDHFANEPDSLDPRAYLQKAKEAAKEMAKSKIRMVGSE
                     NTVVPAFV"
ORIGIN
        1 catcttgaag cccctgcttt agcagctcgc caaaggcatc atcgccaaca cgccctatca
       61 tgcggacgtc agcaccaagc ctagctgcag ccacagcttg atttgcccct ttaccaccag
      121 gcactgtttt aaagcccttt cccattacgg tttctccttg agctggcaca tggtccgtac
      181 tcgtcaccat atccatgtta atgctaccaa tgacagccac ttttcgttta accactaggc
      241 accacctcct tttgttgttc ctcgtatggt taaagtcgtc ggcagttcat gccaatacga
      301 ctgcaaagac cttttttcta ttagttgcac caatagttgt atcgccagtt cgcccatctc
      361 gtatatcggc tgttgtacgg ttgttaacga aggcaccaac atattgccaa ataaaatgcc
      421 atcaaagcct acaatttgta agtcttctgg aatcgagcgt tttaatgtat gagctgcttt
      481 catcgctcca gccgctgcta catcactgct tgtaaaaata ccatcaattg tcgggtgttt
      541 ttcaagcaaa gcacgaacgg cttcttccgc ttgctctatt tgaaagcccg tctccacgat
      601 gatatgagca attccatttg cttcaacaac ttccttaaac ccttcgtatc tctcatcagc
      661 aggattcaag cctttcggtc cacgcaaatg agctataaat gcacaacctt gttcaattaa
      721 gtgctccgta gcagcctttg ccccattttt gttttcagat acgacagtcg gaatgttggc
      781 gctaacaaaa cggtccaacg caactacagg caagtcaagt gtctcatagt gttcatatgt
      841 cccagtgcca gtcgctaaaa taagcccgtc tacatacttt tgttgaagag cgtggacata
      901 atgttgctct ttttttaact cgttatcagt attgcacagc acaaccgtgt accctttctt
      961 gagtgccaca tcttcaatcg ctcgggcaag ttcgggaaaa aaagggtttg ctatatcagg
     1021 gacaagcaac ccaatcattc ctgatgtttt atgataaagt gtacgcgcta cagcgtttgg
     1081 tttataattt aacgtttcaa tagctgtctt cacagcctgt tcagcttctt tgctgacata
     1141 gcctttttgg tttaacacgc gcgagacggt cgccacggaa accttagcgt atttcgcaac
     1201 atccttaatt gtcgtcatac tcattctcct aacacatgta accggttaca gataatatat
     1261 gacggaagcg catggttgtc aatagacaat ttctttcatt taatggttat ccccaattga
     1321 ctacagacgg ctaaaaagca agaaacggtt tccccctttc acgtaaaagt gcttcagact
     1381 ccggaatggg caaatcgttt gttcaaatga tgcgactcat tttcgaaagg ctcttgtcca
     1441 ccgaaataaa aacatgagag gagatgcggc tgcaaggaag gttgaaaaaa gagttcaagt
     1501 cagctcggat ctcctcgacc gtgtctctaa ctgttttcta cttcaattta caacgcccct
     1561 atcaatctca aaccttttaa ttgatcgaac agcatttgca tcccttccct ctctatcaga
     1621 aagcatctag ctgaaaaagg atcagagctt gtgatgtaag tgacactttt tcaacacaat
     1681 ggacgttgat ttttggaaga gaacaatgcg tgatgcctag caacgattta ttggctgggc
     1741 tgctttagct tcttgtgaaa atatcaagca catttgtccg aaaaacagaa aaatctagac
     1801 gaacagctat gcgcgggcag taaggtccac tgcatgcgcc cgaggcaggg cgaaaatcag
     1861 cgatacttag tcccgatgag tatcgacctt gatcttcaat ttgaacgttg cgccgtttat
     1921 agtctaacaa attcggaacg tcgattgcag ccatcaatgc tgtgagatca tgttgcggcg
     1981 ttccctgaat accaggttcg agaacttgat aagactcata ataaaagtca agcatcggct
     2041 taatagtacg aagcaatggc gtcgttgctt tagagttaat caaattgacg tcggctggcg
     2101 taagcaatgc atccctcgtc acattcaacg gcacaatggt tacatttggc gcatgtgtac
     2161 aaacaaaatt ggcggcagtg gcatctccta aaaaattggc ttccgctaat tcagtctcat
     2221 ttcccggcac taaaaaagcg cctcccatga gaaacgtcgc tttcacccgt ttcataacgg
     2281 caggattaat catccaagcc attgccagcg tggtgcaacg gccgagaacg acaatggtta
     2341 tttcatttgg attctcttta atcacttgaa acaaacggct aaaattggtt cgattcgcat
     2401 aacgctctgc tggaatgggc ggcctaatcg gcccaagacc ttcttctcca tgaatatccg
     2461 ggaagaattc cggttcttct ccatttaacg ctcgagtcgc tccagcaata accggaaccc
     2521 ctttccgatc ggccaaactt agcaaatacg atgcattgcg caatgcctga tcgcggatta
     2581 cattgccaaa atcacctaca atgcccgcca gttccacgtc tggatgctgc aaggcgtaaa
     2641 taatcgccat cgcatcatcg atcccagtat ctgcaaatac caatagttta tttgccatct
     2701 catcatcacc tccatatacg ttatgacaca gaggacaaga tggcttagtt taacaaccgt
     2761 atcacactaa aattgagtga ttcgttcgta taattacaat tacgataaag caatgtccgc
     2821 tcttagagaa cgcgatggta tcaagaaaac ggacaacagg attggattga aatgtttcag
     2881 gaaggtagtt gaattaagca ggcaaatggt caacctcgtt gggtaccatc cccgaatgaa
     2941 tgtggtgagg aatatagagg agttggatgc gtcacgagat taatagaagc agatgctttg
     3001 tgcatctgct tttaaaccgt aagttaaaaa acactggttg ctttcaaggt atgtgacctg
     3061 tttctctttc aatttcaaat tgatctaacg tagatcatga ttctctgatt gagatcggca
     3121 aagtcgcgtg taaccgtaat cgttctttcc atctcttggt gagaaacagg cagcttatgg
     3181 ttcaaaatga cttttaccta cacacaaaga ctctcctatt ttagtgtgac ttttccattt
     3241 tcacaaaatt atttctttgt cgttagttct tttaacaagg caatcatctc tttgttctgc
     3301 tttattattt catttctttg ttgtctagcc ttccaaaaat ccactaaaaa gcccaatagt
     3361 acaattagga ttaatatcgt cataacgcat tttctcctac taattattta agcaatttcc
     3421 gatgtttcaa accatagact attaatcata aacattcgca ttcactttca ttttccatta
     3481 gtttacttca aatcagtaaa cgttaccagt agttatacca attgattaag gtagttatga
     3541 gagactcggc actagtgttt ttctagctac cttagatctt tcactattga gagaaaaacg
     3601 ttcattgtct tctattattt agttttttag aaatacgaag acataacagg cccatactaa
     3661 tgaaaacgag aaaagggatg atggcccata agggagttac cactgtccaa aacagaagat
     3721 aggcactaat agccatacaa agccaaccac aaataagaaa agcgctcgaa aaaaatcttt
     3781 catatcaaca caccgtcctt aaaaaaagta cacctgtcaa ccgtttcaca caatgcttat
     3841 tttgaataga acatggctgt gcatcatagg tgcgcgtccc ttatataaga actcataaac
     3901 aaatcaactc ctcccctacg caaattaacc catgacgata gtctggtagt ttgttacaat
     3961 taccatatta caccacaaag gaggaactag cttgaatacg ttatttctat tatttttatt
     4021 gcttactttt ttcggtctca ttttagggct aatcaagcct gctctggttc gctttccaac
     4081 tagaaagcgc gtttttgcgt acggcattcc agcatttatc attactgcat ttttatttgg
     4141 caacacactt ccggccgaaa cggcccagtc cgcccaacta gatcgttcgc aagcaaaaat
     4201 cgaaacctta gaagcatcct tacaagacaa agaaacggaa atggaagaat tgactgttgc
     4261 gttagaggaa gctgaggaat cattaaaaga gtctgaagag cagttggagc tcctacaggc
     4321 ggaagaaggc gacgttgacg gttcttttga agagcaatta gaggaagcaa aacttgaatg
     4381 ggaagaggaa tttcgggaac agatcgagga agaactggaa gaacgcatca ctgctgaaat
     4441 tagtgaagat tatgaggaca agcttgctgc attagacgat aaaatcaaag aaaaagagca
     4501 aacgattgaa gagaaggaaa cgactatctc gaagttggaa gaagaagtgg ccagcgcctc
     4561 gactaataac ggaaatgaaa ccgctaccac agaaacagag actgcacagt cttcagaaag
     4621 cgcaagtacc gatagttgtg ggcctggaac ggtgaaaatc aacagtgctt ccgagtctga
     4681 gctgcaagcg atttatgaaa ttggtccaga tcgagccgca caaattattc aactccggcc
     4741 cttttcctct tataatgata tgaaacgaat taaaggaatt ggcgatgccc gtgccgaagc
     4801 gattgaaaac caaggaattg tgtgctttga ttaaaaccac tgaaatttaa tgccactagc
     4861 gcaaaatgct agtggctgtt tttcgggata gcaggtaact gaaaggaaac cactgcgcct
     4921 ttgtcattcc atgcttgaac gtttccgcca tgtttttcga ttatgtgttt gacgatgtaa
     4981 agcccaagtc ctttatgagg gtcagcacta tcgttattct ggtaaaattt ttgaaagacg
     5041 taatgcaagt ctgattcagt gaagcctttt ccattgtcgc ttacagtcac ttttacgtaa
     5101 tcgtcatggc attctgcgtg acaatcaata tgcccatcat atggttcggc gaaacgtaag
     5161 ctgtttgata tgaggttgtc tatcacttgc gttatttttt gcacatctat ctgaatcgtg
     5221 ttcgctgttt ttctgtagtc gagaacggaa gtgtgaaacg tcagtccttc gttttgaaca
     5281 aaatctttgt actttgcaaa ttcagtttta aaaaaatgac ctggttcgac ggtttttgtt
     5341 tcaatggcaa aaaaagactc ttcgtcgttc attttagtac caagctcttg tacgagtttt
     5401 tccgtcctct caatttcgcc gatcatattc gcaatatacg ttttatgctg ctcatctttt
     5461 atctttctct ccaacatttg cgcgtttgct ttcatgatcg tcaatggcgt ttttaagtca
     5521 tgggagacag acgaaataaa ctcggaacgg tttttttcca agttccattg ctggtaaaga
     5581 gcgtcttgca acgcttgttt cattatattg aatgaagtcg aaagttttgt gatttcatcg
     5641 tttccgtcag cctcgatttc aaaatctaaa ttttgctttc ggaccaattc tgtggcgaca
     5701 atcaattttt gaatccttgc gtaatagttt tttcctagtt tgctcgcata ataataggta
     5761 aagatcataa taaagaaaaa tggcgtgagg aatagacaaa caaaaaaaat attaaataag
     5821 gcttcaactt ccgattccag tttatattga agtacgacac tgccagcaaa tgtaccattt
     5881 tggtcgacaa tcggaataaa cgatgtggcg gtgttctctt ccaaaaacga tttgttgacc
     5941 ttgtttaaca aatggacgcc ttctgggttg acgttagcgg aaaatgaacc gtacaagaat
     6001 gttccttgtt cgtccagcac ttggtattcc atgcctgggg tgggaatgat ctcttctaat
     6061 tgtttggccc ccgacgcttg cgaattgaca agctcacgat tcaagctttg tacttgatcg
     6121 gttatttggg ggacttggct ctcatagtaa ttggcataat agcggtcatc gatgctcatg
     6181 acaatcgccc aacttgccaa aacgacaatg atggtagcaa agaaacttaa taaaatcgtc
     6241 ttggctattg ttaatcggat ttgctgttta atggacgttc tttttttatt caagtttata
     6301 gcccactccc cacacagtat ggatcagatt tgccattgga tcaattttat gaatgcgtat
     6361 ccgaatattt cggatatgtt ctgtcaccgt gtgtgattgt ccagttgctt ctactcccca
     6421 aatcgtctcg tatagatgat ctttcgaaaa aatttgcctt gggttgctca ttaacatttc
     6481 cataatttta aattctttgt ttgtgagcaa caagggggtt tcgccatagc ggagctcatt
     6541 tgtccgccgg tcgagtttta tttttccata gacgagttca tctgtaggtt gttgcttccg
     6601 tttttcccgt cttaaatgag ttttgattct agcaagtagc tgttcatggg taaacggttt
     6661 gtttatgtag tcatctcccc ctatgtttag cccattaatt tggtcgttca tacttgttcg
     6721 agcggtaaca aataaaatcg gaacatcggt aaattccctt acgctacggc aaacatctaa
     6781 cccgttcaca taaggcatca tgatatcgag gatgattaag tcaaaatcct gctccttaat
     6841 cagctttatc gcgttcattc cgtcattggc gactgttgtt tggtagcctt cttcctgtaa
     6901 cagctctccc acaattgaag taatttgaat ttcatcatcg acaatcagaa tgtgctccat
     6961 tttatcccct cacaaaacat ttatttaaaa tcttgcttta cccataataa acttgaaatc
     7021 cctccgccaa acagaacaat taacggcaac gccatgtaaa gcaatggcat gttcgtttcc
     7081 gaaagcgaaa taaaaatgga ttgagtgggc atcaacaaaa atgtcagctc atttgaaaaa
     7141 taaattggca ccacataggc aatcattaat aagaagtacg caataatcgg gtttggtgcc
     7201 ataattgaca tcacactggc aatagcaatt ccagcggcaa tgacagccca aaacaaaaaa
     7261 tagagcttag ctgaataaat gtatccattc agtatggaat agcgtgtaag gtcaccataa
     7321 aaagtcacgt attctggaac ttggtaaaag aaaaagccta acatgacacc aatgagccaa
     7381 ataaacacgg tgatgaagac agcaatcaga agcagcgttc cccatttaga cagtaaaaac
     7441 tctaaacggt gaaatggacg gtacaacact aagttgtacg tttttgcttt tattggtgag
     7501 ttcaaaacaa ccacgcaaaa caacggcatg atgactagtg ttacaaagaa agagacttcc
     7561 cttaacaaaa accagggaaa gttaacagca tttaacggcg tttcactatc tgcagtataa
     7621 agacctagat cgaaccaagt caaaaagtaa gcggaaaaaa aggagatgcc tacgagcagc
     7681 aacaagagga ttttcatcat tctcatcttc caaagccgct ccaattcact tatgattaaa
     7741 tgtttcatca tacggctcct ttacacataa taatttcggc gagtaaaaac caaatacgcg
     7801 cccccaagaa agaccaacaa ataaaacgaa gtaacggcta ttagccaacc gctcaattcc
     7861 ccgcctgaaa gcaataacga gataccggtg tattgaattt ttgttatgga ggcgtacacc
     7921 acataagata tattgctccc ttcggcaaaa gcggttgatt gctctaacag ctgcggacca
     7981 acaatcgaaa agaaaaggat gcaaatgccg cttcctaata aagcattgac agagggcatt
     8041 aaaatcgcga taaagcaaaa taacgagagc gccgcaagac tagtaagaaa ggcaatgcca
     8101 taatagttca atccataaag aaccatctcc gtatttgtaa cgtctgcttc agaaacaaaa
     8161 agaattgacc tttcaggcat ctcaaacatg atctgcccag cgaagaagga ggccaagtaa
     8221 taaagaaaga aacaaataaa taaggaagtg gccattacaa tgaatttgga cagaaaaatt
     8281 tggctcatcg aataagcccg aagcactatt aatttgattt gtttttgttg atattcctcg
     8341 gttatcacat aggcacaaat aaaaatgagc agaatgttga acgtaataaa caaatgctcc
     8401 gatatgctga gaatagggaa atttaaagcg gttgcgtaat caacagtatc cattgacctg
     8461 tttcgattgt gatttttgaa ataaacacca gtaacaatga ctaatagcgg caaggtcatt
     8521 actagcagcc gaatggacca tcgcgaccat aaccgttcga attcactaat gattagttgt
     8581 cccattatgt catcatcccg ataaaaatat cttctaaatt attctctgtc ttgtcataaa
     8641 tctcttcttg ttttccataa aaaaggacat ttccctgctt aataataaca agcgtgctgc
     8701 atatcttttg gagttcgtcg agcaaatggc ttgatatcaa gaatgtgata tttttttctt
     8761 tatttaattg caaaatcaat tccctcaatt ccctcatccc cattggatct aggccattgg
     8821 caggctcatc caatatgaca atctctggat tgcctaacag cgcctgagcg atccctaaac
     8881 gttgcttcat tcctaaagag tacgtccgta ttttttcatc gccgcggcca tctagaccaa
     8941 caatcgtcaa tgcttctgcg actttatcct gtcgctcctg tttgttcaac ccatggagtc
     9001 tggcaaggtt taaaagcatt ccgcgacccg tcatgaattc aaagaaaatg ggcgactcaa
     9061 taatggcgcc aacagaacgc atcgcttcct ttcgctgctt atgcacattc cattgattca
     9121 gtttcacttc tccgcttgta gggatgagca atcccgtcaa cagcttcata atcgtcgttt
     9181 tccctgcgcc attaggaccg ataagaccac agatctctcc cttggcgatg gaaaggttga
     9241 tttcttccac taacggtttt ccttttattt tttttgttaa attctttgtt tcaatgatct
     9301 tttccatcgg ctatcactcc tttttctaaa aatgattatc ccttttccct atcagaaaaa
     9361 aatcaaattc aacatccgcc aaaacaacaa aaaagctagg acgtaccgta cggcgtccta
     9421 gcttttttct tctacagcca tggctttatc tatctcttga gcgatggtat acatatctgg
     9481 aataataaag ttttttcgaa tgcttcccga agccacttca tatgcttctt tttccactgg
     9541 ggggatgata atatgtcctc cctctttaat caacgctata tttcttttta caaaaaaatt
     9601 gttccacatc gcctcattca tgtttgggca aaagagcacc ggcttcgtag aagccaatat
     9661 ggttgatgac agaagatcca tgcctaagcc attagcaact tggccgattt tatttgccgt
     9721 agcgggaagg acaataaata gatctgccca cctagctaac ccgacatggc tggacgtatt
     9781 tggatctatc gtttcattgt gatcctgaaa aatgtcatca caaaacaacg acaaagagga
     9841 tgcaggaaac aacttattgg cttgctctgt gatgatgacc ttgacatgac catacgtatg
     9901 tttaaaaaaa gctaaatagg agggcatgtt tatgacagag atcgatccag aaattccgac
     9961 tagtatgttt ttttcttcct tttccggcac atcctcaccc ctaactgatt aaaaacgctt
    10021 tatcccagaa gagatcactg tcgtcaccgg tcctcgacaa taaggccaat ccaacgccag
    10081 ctgccccttc caataagccc gctttatcta actcgtttgt tcggcttccg atttcaaaat
    10141 ctttaaatcc caacggatgc tgatccctat actgttcctt aatcccgttt tccaattgat
    10201 tgatgagctt gtcaaaatca ttgatgttaa gatcgttttt catccgtacc atgatttgca
    10261 gcaaaccact ctttccgtgg caaaacgtcg cactttgcaa gtctagttct tctaatgttt
    10321 tttccttaat accgtggaaa cacttaaccg ccatttcctg atagggaagc tcgttcagcg
    10381 ctttccctgc taaatagagc gaccgggcaa caccaggatt gccataacac cagccttccc
    10441 gttcatctat aacggtatat ttgttcgcta tagcttcttt cacacctacg cgatgggccc
    10501 aaactggagc accagttgaa ttgcttttcg catgacggac gagccaattg ccaatcgtgg
    10561 ttattgcttg cctttgccct ggtatctcga tcccttttaa tagacataaa gataaaaaac
    10621 ttaacggccc tgggatgcca tgggcaaggc ccaaattgaa gttgccaaat ggataaatct
    10681 ttttatcctt ctctaaaaat tgattctctt gcgtaacata ccatcctgga acctcatgct
    10741 cttcccatgt tatggtggca gtcatttcaa caaactggcg caaaatcgct tcaattaagc
    10801 cgttaaaagc tggcgtatcc tttcttcttt caagcaaata ccttccaatt ccagaatatc
    10861 cttggatcac atcataaaaa gttggtagag cgccgagacc attcctttgt ttttcttctt
    10921 cgatttcatt ctctgctacc ctacgaatca cttcatccag ttttgccaat aagttctggt
    10981 atcttgtacc attttcagat gcattgaaca cagcaaaagc aaatcctgta attccaccaa
    11041 ataaagagat agaatggacc ccatttttta gatagttgct agcgtagaca atatgattat
    11101 gggccacatg atcccacttc tcttcaggat acattttatg caattcagag aagaataaaa
    11161 tcgttcctgc aaaaccatga gataaagaaa cagggtccca cggatttact ttgctaatcg
    11221 tcgtgacatt gttcttatcc attacaatct cttccacttt ttgtggatcg tttagtttct
    11281 cggtcaaacg ggcaataatt cgtttcgttt cttgtttttc ttggtcatca actaccttct
    11341 ctatcacggt ggatcacctc atacgtttaa tggtcgccct ttcgttttgt tccaatgctt
    11401 ttgactttca ataatttggc gcacaaacgc cattgctttt ttctccctat cacggtctgt
    11461 gccgagcaag cggttgcaat gcatatggat caagctcccg acaactcttt cctctgtatt
    11521 ggtcatcggc gttatctcca tattatggga tagctcgtgt atgattgctt cgtttttaga
    11581 aaacagctta aagagaaagc ctttctgctc ctttagagcc ttccagtttt cttcttgatc
    11641 tagccattta agcacatcat ttcgataagg cctaaactcc ttggagtaag ctggatcctc
    11701 actccacttg gaaatccact ccaattgcct ctcatggtgc caaccgtact ccgttagaaa
    11761 ataaacaaca tacatggatg cgattaattc tagcggttct ttcagtgctt gcttactact
    11821 caatccaagc aaatttgatg tcaacaaact gtctttttca aagtatcgct ccattagagg
    11881 cataagcgaa aggccgccgt atcgttcaat ttcccgttca tatggctcaa ttacaacttt
    11941 tttaacgttc cccgcaaggc gctgggctgc ataccatttt tgaaataccg gcagtgcacc
    12001 agccaacaag gttttcggat ctccgtgaaa ccttagccgc agatggggct cgctgtcata
    12061 atagcgaata aagaaccagc tatttataag tttgtgattc tctaactcgg ctacaagcgt
    12121 tggaatttgt gtagaaatca gtttttgctg tttgtggata ggcccgtaaa gcttaaaata
    12181 aagccagtcc gtccccggtt ctttttccct gcattcaatt ggcacttctg caactggctt
    12241 aatcatcacc gttggttttg cgggcacatg aggccttttc ttgaaaggaa caataaattc
    12301 agcattatgt ctgcctaaag ggctttttac ccactgcttc tcccgataac cgccgatgat
    12361 ttcttgtaac tgtacccgtc ctctgcgccg tagttccgac cttaattcct gcatatggtt
    12421 ggcatttttt aagtggatgt acaatcggtt atccccataa gccataaaga cctgttctgg
    12481 tacctgcatt tttttcatcc atgttgaaaa ttgctctatc cattcttcaa gaggcataga
    12541 aaaatcagat aattcttcta tttgatcgtt taatttccaa attgccggtg aaagaatgac
    12601 ttttccagac gtaattctag gaataaaagt gaactctcta aggcttccca aattcacccc
    12661 ttgaatcgcc tttccatctt ctaaagaaac ctcccttaaa aaccgaaaac aatttggtgc
    12721 actctcgtaa ttaaacatgt tgtttgacgt aaatacgaga cgtttattcg acttcttcga
    12781 ttttaaataa aacctcccga gtgtcgcccc aaccaaaata tcttctaaca acaatttttt
    12841 gttttggccg tttgcattgg tggcaatagt cgtatgtaaa ttccgtgtgg aatgcgtaat
    12901 agaaacgttg cttgcacggc cactttgggg cagaaaactc aactctacgt attcggtttc
    12961 aacgtccgta catgtttcct ctattttctt ttgttcttcc atcaaatttc tattctcttc
    13021 gctagcaatc atatccgaga aacggccgaa tgtttgccct agctcttggg agcccacatt
    13081 ggttcctatt gccaactgat agtttccttt atcaacttcc tctgctgatg aagcaagcac
    13141 ttcaacaaat aattccccgg aattgggagc aaaaacgtca tctgtgtcgt tatccattag
    13201 cttttgcagg tcagattcgg tcaatgttat ttcttttgca ttttccctta aacactggat
    13261 gtatttttcc attaacaaac gatgagtgct cttcatttga ggcgggttga cactttttgc
    13321 tgaaggcggg tatttatacg ttggcggcgc ccctaaacct ttctcatcgc ttaacaaatc
    13381 tagcagagga atttctcgat ttaccccata tttctcaaga aattcaacat ggtactccct
    13441 taaatgggcg actccagtct cattttttga aagcctccac agccactctg ccgcattggc
    13501 cacttgttcg ccaattgacc gatttatcct aaccttttct gcgcatgtta agcgcaagtc
    13561 cacttgcaac ggctgtttgc taggatgaat gtcttgcatt ttagccgtta gcgtttgaaa
    13621 gaaatctaat ccctgcccta taggcaattg gttatacgtt tcgatatcgg cttcaattcc
    13681 ttttaacatc gcccctattt ccgtcgcttc agggatggat tcaaggattt gtatgacata
    13741 ggataaaggc gcacagttaa cgattggcgg ccttaattca ctgataagaa attcttgttg
    13801 gaataaattc catacaaacg attcaatttc atttatagag gcgctcgtat atgttaattg
    13861 aagctgattg attaattcag agatcgaaat cggctttttc gctaccgatt ggacaaactc
    13921 caccaccact gtttttctga tcgagatatt gtcttttcgc tcttggtttt cactgcttcg
    13981 taactgtcca cagttagaaa aataatgaag gtagactcga tcgtccgtct gatacacagc
    14041 atcattaaaa acaacgttaa gctttttagc gatcgtttgg tttttttcta ttttgctgac
    14101 tactccaagc aaccactcca tatctggacg tgctctcttt tggtgttgct tcgtgtctaa
    14161 taaagatccc actgtcttat tgccaagttc accaatagca atgcctgaaa acaaaccaaa
    14221 aggagttggc cggctagaca tccttattaa aaactttaac aagctggaaa cagcgttcct
    14281 cgtttttttg gaacggggat cgccatgaat tttatctaaa gactgaaata aattagggct
    14341 ggcaaccgct agtgcttctt ttatttcagg ccgttctatg tattctttta aaatagggat
    14401 aatatcgtct ttggacgcgt tttgatggtc atgcgataat gacaaaatcg gtgctctcaa
    14461 catgattgtg tctacaggct catataataa ttgttcgctt tttctcatcg ctatgaacgc
    14521 ccctttcaaa tgaaaaacaa acaggattgc ccttgctcaa gtttataaat ctgtattttg
    14581 gaaaaataca agatttttga ggggcaatcc catataaata atcaaaagtc tttgtgctta
    14641 gcagcagaag ctattaaagc tacccgtttc cccgcaacca ggagtacaga aactgacgct
    14701 tgtgaaatct ggttgtacat ccttcgcttt cgtgtgtact acttccaaat ccaagtcaaa
    14761 agctttttcc attttataat tcctccccta ttttttttgc caggaatccc cggcacaaat
    14821 taactgtaaa aaacatttta gcaaaatgga aatatcgttt tcagtcatta attggctaaa
    14881 aatgatccat gtcgatgttg agcctgtttt tttacagtat ctcttataaa ttatgacaat
    14941 tagaataact ttgtttgttt tttgaaaaac tcactactat agcccctatt tttttggaaa
    15001 atacatgttg aaatttggtc gatctgatat atttctgata aacgcctgat aatctttcga
    15061 taaccatcct cacttaaaaa aaccaactaa tacaggttat gataaggaag atgcatatga
    15121 tggataatcg aattggcatg gagatccgaa acttaaggat gaaactaggc atgtcgcaag
    15181 aaaatattag ctctagcgtt gtcagccaat cagcaataag caaaattgaa aatgggaagt
    15241 acattccaaa cataatcgtg cttgaagcca ttgcttctaa actaggggtg cctgtcgacc
    15301 attttttaac gctcagcacg tcctacaatg gtgaatacat cgaaaccact tatgaaatga
    15361 ttgaacaact gtctttacat gaagagtacg aggaactgaa caggctaact gcacaattaa
    15421 ttgactgtgg ccaggcggtg gaattcccta attggtttaa agattatata aggatccatc
    15481 atctgttctc cgaatatcaa tgcaggaaaa aggatgctca aaccacatgg atgaaattaa
    15541 aatgcatggc gggctgtttg ccatttgaac agtctattca aacaaagttt catttatatt
    15601 taggcattat ccattcccac atgaaaacat attcatatag cgaaacgtta gactatttac
    15661 aaaaaagcct tgcatcggtt gaaggaatta aaggaaaaaa cacctatttg cacaaaaaaa
    15721 acttaaaaat ctatattttg taccaaaaaa caatcattga actgaactac caccactatg
    15781 atgctgcttt aaaagatata ggacaaggtc tgcaattatc taggaattat gcttgtacgg
    15841 catatgtcgg gcaatttctt tattataaag ggctatgttt agaaaaaaaa ggtgttccct
    15901 tcaaaaacat tttaaagcac tacgaggaag cgcatttttt tgcaagcttt acaaacaatt
    15961 tgcctttcaa gaaactgcta tcagacaaac tttcggccag gaaggaagaa tcatatgggg
    16021 tctacaactg aacgaccgat tcaattaaaa gagttcattt ctctaatgcg cctttaccgc
    16081 ccttcactgt ggctacttgg gctagctttg tttttagtcc tgatggaaac agcgctttct
    16141 cttgctgtcc ccttattaac aatgaatctc gtggacataa ctgttgaatc aaatttcagt
    16201 ggtacaacag ctgccctaat cgcaggcgtc tttatcgtac aaattattct gtcaggcatc
    16261 tccatgtata tgatgatcta cattggtcag atcatggtgg caaaattacg caaagatcta
    16321 tggcacaaag tgttacgatt gccagtctca ttttatgacc ggaacagctc cggagaaaca
    16381 atgagcagaa ttactcatga cacaaatgtt attaaaaatt tttttaccga tcaattgatt
    16441 ccttttttat ctggaaccat taaaataatt ggttcgatta tgatcctgtt tgcattaaat
    16501 tggagcatca cgctgctctt attgttaatt gtccctgtgt cgctagctgc attaaaacca
    16561 ctaggtagaa aaacatacaa agtgtcgaag gcattacaag atgagacagc atcatttcaa
    16621 ggggatttag ggcgtgtgtt gtcagatatt agattagtca aatcttctat agcagaagac
    16681 ccggaaacat ctcaaggcaa caacagaatc gatcaactgt taaaacatgg attggacacc
    16741 ggaaaaataa tggctatcat ttctccattg atgacaacca ttaccttgtt ggtattagtc
    16801 gtcgtttttg gttacggagg catacaagtg gccaatggca ctttatcggc cggcacatta
    16861 gttgcgattg ttttttacat gttccaaatc atccctccaa tctcacaaat gggccacttt
    16921 tttacgcagt tgcaaaaagc aaaaggcgcc acagaacgga tcacctatat tatggaggag
    16981 aatttggaat ctcaattagc ggctagtgta tcttatccgc acaatcaaga aacagttgcc
    17041 cgcgtaaatg gcattcgatt ttccaatgtg tctttctctt atccgaatgg cagccaaatc
    17101 ctgaaaaatg taagcttttc cgccaatgcc agtgaagtaa cggcgattgt cggccctagc
    17161 ggtgcaggta aaaccacctt attctcatta attgaacgat tttatccacc aagcgaaggg
    17221 tcgatagagt acgacaacca accaatcaat gactttgatg tccaggagtg gagacaaaag
    17281 atcgcctatg tcgcccaaga ttctccacta atggcgggga cgattcgcta caaccttact
    17341 tatgggcatg ctgaaaaaag cagcgatgcc gacattcacg cagctttaga aaaagcaaat
    17401 ttgacttcgt ttattacctc tttgccggac ggcttagaaa cggaagtggg cgaaagaggc
    17461 attttagtat ctggtgggca aagacaaaga cttgcgatcg ctcgagccat tttgcgaaat
    17521 ccgcaaattt tactgttaga cgaggccacc gcccatctag acagccattc ggaattttta
    17581 gtacaagaag cgctcaatca actcatgctc tctaggacaa cgctagtaat cgcccatcga
    17641 ttgtcgaccg tgcagcatgc agacaaattg gttgttgtcc aaagcgggga aataacaggc
    17701 gaaggaacac acgatgaatt aatcgagcat caccaatttt atcgtgaact tgtcgatcgc
    17761 caattatata agaaagaatc ccccgagttg atcaactaaa agagcacgta gacttttaaa
    17821 ggaaagtagt gaagattgat gatagccatt atcctgtttt gtttaaacgt tattttgtat
    17881 tatgtgagca ctctttttca atttgaaccg acatatacga ttggcttatg gacgttcctc
    17941 tctattgttg gagtcttgtt cgcgtttaaa gctgctaaac catctgtcaa aatcattggg
    18001 ctcgttttaa atggcgcctt tctgcttttc tctctcttgt tgattattgc tttgtttctt
    18061 taagcagtga gaagctaacc tatttagcct gatggtatag ataagatggc ctactgtaat
    18121 tgagctgact tattggtcag ctccctttct ttttacccgc tcccacccgt attcctcgat
    18181 cgatcgttag cgcaaacttt gctagcacgg gaccatttcc ctttttcaag cccgctcttg
    18241 ctcctgtctc cccctaattg cgtacgctac acaccagaaa caagagtaac aaacaaagac
    18301 agacacctat ccgcgtttct gccatacagt tgacgaacag acagccaaga ccacagataa
    18361 cggaggaatg cccagcccac tatcgggatg ggttaacatt tgcattcaac gatgaacaaa
    18421 atacagtgga tttctaccta aaagcagctg accgagcttc tcagcaaatt gtccaagagg
    18481 cttttcgcag agccgcagcg gatgagcagc cacacgctgt ctggtttctt tcttttttga
    18541 tgagaacatg aaatggatag caaaacgcaa acgtctcaat cgctgcgacg cttgcgttta
    18601 tttggtgttc ctatatcgtt ttagcagaca gcgcttcgat agtaaaagcc aacagcagag
    18661 cgcgctcttc aagcgactct atatctaggt attcttcttc gctatgttgg tttcccccga
    18721 ctggtcccat accatccgga cagcacccat cctacaaccg ctaaaatgag atatgcatct
    18781 ttcatagtca accccttttt cacacgtgaa cgacccactg ctagctcagt cggattgctt
    18841 gaagtggggc ttctgtggca atcgccactt ttgctagctg ttaatggtac cgtttttatt
    18901 aatacgcagt cgtaccataa cgaccttaca gagaaagacg tctgctccta tttatcatgt
    18961 acttggttat aggcgttttc aaaaacacgc aacgcttctt ctaaatggct cgtatcagcc
    19021 atacaatgtt ggcggtgcca ttgcaacgct tcttttactt cgtgatacag ctggtcgtca
    19081 taccttttcc atacacactc ctttgatgct tccacggcat tggcttgcat tgtcagaaaa
    19141 gcaatgcttt tttggatgcc cgtgtataaa caagaacaga cgctgtaggg gatatccgcc
    19201 acttcttcac ctccttgtca ataaaatcag tcttttcaaa atgaggcgcc ttcaattcgt
    19261 aagaggatac acggcagtgg ccgtaccgaa tgcccttaat agcacgtgca agtcatggag
    19321 ttatgtagga aggcgctccc atttatagtc agtttagcca acgtaaatta gggagtcaag
    19381 tgttttaccc aattttacag agtgttcatg ttcgttttgt tcctttaccc aacttttagt
    19441 tgtataattg tgacaataac aaataggaag gatttgttta tggctgaact gaatgaccgc
    19501 ttacgagagc tgcggaaagc tcaccagcta acgcaacaag aagtcgcttc gttccttggc
    19561 attacggaaa gtgcatacgg tttttacgaa caaggccgca acgaaccttc gattgccaaa
    19621 ttaaagcagc tcgccgagaa atataatgtt tccattgcgt atattgcggg agagacagat
    19681 atcaaaactg ccccgtccga caaagtaaaa gaaaacggct ctgcttatac gtttacgaat
    19741 ttagatgagg aagaaaaaga atttttaggt gaacagctcg aattatttcg caggcttaaa
    19801 aagaaaaaag gccattaatg ctgatccagt acggataaaa gcgcttaaca gctcgttcat
    19861 cagcaatgag caggctaacg cgtttccagg atcaacgcct gtctgttcgc tgcttcttaa
    19921 aataatagga aaggaagtct accattggac caattttcaa tcggaacagc cctttatcag
    19981 atttttgcaa tcgtgttttt gttcggcttc tttgggcttg gtggttattt tcttattctc
    20041 ggcattcgct attttaaacg tgaattaaaa aaataagacg agcgacggtt ggcactaacc
    20101 gtcgctcgtc tgtttgattc tttctctacg cttcaatcac atcaatcaaa tcgcctttca
    20161 ccgctacacg ctgctggcca gacagcgtac acgtaattaa tgtaatttcc ggctgctctc
    20221 catcgtttaa cacatctaca tcagttggtt cgataatttc cgtgctcttg accacataaa
    20281 tatacgtttt gccgtcatcg gcatgaaggc gaatttcatc acctttttgc acatttggca
    20341 attgccggaa atgcctgtcg cctcggtagc cacgatggcc cgcgaccgcg aagtttcctt
    20401 ctcctggcac ttgttcttgc tttatttgcg ttagcgttaa ggccaagttt tcatccgtgg
    20461 tttcatcaag tatatactgc tttaagtcaa ttgcagggat ttccagttcc atcactgcct
    20521 ctaactgttc ttttgtccaa gaggatggtg aatcatccgt cttttcaatc gtttctcccg
    20581 tttggacagc ggctagcgct ttttctagtt gagccactcc atttgcctgc tgccactctt
    20641 ttgttagcgg gacagcgaca agcgccagtc ccgcaatgat gagcaacatt cctataaaaa
    20701 gtgtcctttt tcgcaagaaa tgccccttct ttctatcccc tttttcttgc caaacgtccg
    20761 ttcactagtg taagagcgcc aatcgccatc agcaacaatc cggcaaccat aaacatgaac
    20821 atttctgttt cgcctgtttg cggcaattgt ccccctgaag caggctgtgc tccttttgaa
    20881 agcagcggac ttggatcacc gccacctgct tttggtgtcc ctgtcttgcc tgttcctgtg
    20941 ccgccgttat tgttttgtgg cccagttggc gtttggccat cgcctggttc tgtcggtggc
    21001 tgctttggct cactaggcgg ctgtggttct tttggttcct cacctggtgg gatgagagta
    21061 ttttcaactg ttagtacaag ccgctctgtt tggcccttgc taatttcaaa cgcaatcggc
    21121 gtttcgttta gctggtagtg agctggcgcc tttgtttcaa caagttggta cgtgcctggc
    21181 gctaacccat caagctgtac gctgcctgat tcatcggttg tcagcccttc tgcaaccatg
    21241 tcgccatcct ctgttagcac ggtaaagacg gctccttcca aacgtgcgcc atcgctgctg
    21301 tcaaccttca caatttcgac gcttcctggc gtgagcgtgt tttcagcttt gacgacaaca
    21361 gcagcctctt ggctccgttc aatcgtaaag gctagccctt cctcatttaa atcgtagcca
    21421 tttggcgctt ttgtttctac gaattgatag ttgcctggtt ttaagtcggt gacaataatc
    21481 cgtcctgttt catccgttac cagtttttct tggatcacag ttccttgttc gtcttcgagg
    21541 cggaactctg ctcctgcaag caacgtagaa tggtcgctgc tatcgacttt ctcgagtaca
    21601 acagcccctg gaatcaacgt attgcttttc ttgacaaccg ctgcttccgt ttgccctttt
    21661 tctactgtaa ccgccactgg ttctgcgtca cgctcgtaat ggagcggcgc tttcgtttcc
    21721 acgaaataat aggtgcctgg tactagatcg ctaacggcaa cgagcccatt ttcatctgtc
    21781 accagttgtt ctgctaccac atttccgtct gcatcagtca gcataaattc cgcaccagca
    21841 aggcggatat cgccattgtc ttggtccact ttaatcaatg ccgctgcccc agggataagc
    21901 gtgttttcaa ccgttattac tggcgtaaca gtctggcctt tctcaatcgt gaacacaatc
    21961 ggcgtggcat ctaactgata gtgctcaggc gcttttgttt cgacaagttg atagtcgcct
    22021 ggcggcaggt tgttgatttc cagtcttcca tgttggtcag tcataaggtt ctcttccaac
    22081 acattcccgg cttcatccaa aaggctaaac acggctcctg ctaacagcaa ttgttggtca
    22141 gctgcgtcaa ctttttccac aatgaccgaa ccaggaataa gcgtgttttc ttttgtgacc
    22201 gaaacggctg ttttttggtc acgttcaact gttacattga ttggtgtggc atcaagttga
    22261 tagacatagc cttacctctt ttcccttttt tttattccta tattataacg ttgttaattc
    22321 ttaaaatata tagatggaag agttttccca atacgtgaca caaataaaaa aaagacttta
    22381 tattgttaat gttcacttta agtagacatt caaaaaaacg atgagcgtaa aggagtctct
    22441 acccctaaaa ggcatttcaa ggcggcagga cctaatcaaa agctggtaac ggatataacc
    22501 tatgtgtctg ttggagaaga attttattat gtatcggtca tacaggatct ctttaataac
    22561 gaaatagtaa gctgggagct atctaagaga aatgataaca gttcttgcat acagcgcttt
    22621 tcattctcca ctttaataac gcttctaatc ttttcttcag aagtgcttgt ccgaaaaaca
    22681 tgtactagtg atgataacga tttaaaacgt cggtttgttc gacgcgaaat tctagaaccc
    22741 ttttctttcc cgctcatttt ccccttttga tcttgttctt ctgttaagct ctgtgcagaa
    22801 gtagaagaag taacagaatt acctatcacc atttcaatat cctggccgtc atataaagaa
    22861 taacggagat ccctggtgtc ttcttcatca taacttttct gtaagtcctc tttttttaca
    22921 ttaaaacaaa tgaaaaaaca cctccgcttg ttagtacata gcctaacaag cgaaggtgaa
    22981 agactccggg ctcacacttt tcacacaaac gctggcacaa ccgtgttttc actgccaacc
    23041 atgcgaattt ttgattttgc catttctttc gctgcttctt ttgctttttg caaatacgct
    23101 cgcggatcga ggctgtctgg ttcgtttgcg aagtggtcgc gaattgcttc ggagtaggca
    23161 ttttttagtt ctgttgatac gttgactttt gccattccga gggcgacaca acggcgcacg
    23221 tcttcttctg gcacggctga gccgccgtga aggacgaggg ggacgtcgac catttcggca
    23281 attttggcaa ttcgctcaaa gtcaatttcg ggtttgcctt tgtaaattcc atgggcagtg
    23341 ccaatcgcag gggcaagtgt cggcacgtct gtttcttcga caaattggcg gcactcttct
    23401 ggaattgctt tttgggcgtc ggcttcgtct acgacaatgt cgtcttccac gccgccgact
    23461 ttgccgagct ctgcttccac gttgacgcca agggacgagg caagcgcgac gacctctttt
    23521 gtccgagcga cgttttctgc gaatggatgc atggaagcgt ccatcatcac ggatgtatag
    23581 ccggcgcgga tcgcgtcttt gatcacctca aagtctgtgc agtgatctaa gtgcaagcct
    23641 gttggcactt ggtaatgttc cgctgcggcc ttggctactt cagcaatgtt ttttgcaccg
    23701 agtgacttga ccgtcccgac tgtcgtttgc aggattaccg gggactttaa ttccgctgct
    23761 gcttcgagca cccagaaaat gctgtcaaat gaatggacat taaacgcgac aatcccgtgt
    23821 ttgttggctt ttgctttctt tagcatcggt gtcgttgact gtaatcccat ttatttgccc
    23881 acctgccctt cgttttctgc gatttgatat agtagtttaa ttgaatgatt gtctgggtct
    23941 ttcattgctt gaaatggctt gtcgccatct tctagcttaa acacgtcatg gatcaaaggc
    24001 ttgacatcga ttttgccaga cgcgatgtaa tcaatcgcag cctgccattc atagccgggg
    24061 aatgggccag aatagctcat ccaagaacct gtgatttcca attcttcacg taaaattttc
    24121 tcaaacgtcg ctgctggaaa cgtcacatcc cctgacgccg ttccaacaaa cacaatcttc
    24181 ccttttttct caactaaagc gaccgcttgc tcttgggagc tcggcacgcc tgctgtttcg
    24241 ataacagcgc caggcttgcc atgtttgcta gcgtatgaaa ccgggtcctc ttttaaagag
    24301 ttaatcgtgt cgtctgcgcc gatttttttg gcaaatgcca gtttctcgtc gttgatatca
    24361 atcgctgtta ctttccctgc cccgcgtgct tttaaggcga gaatggtcat aatgccaatc
    24421 gttccggctc ctagaacaca gacgtgttcg cctgccggta gcacaattcg ctcaattccg
    24481 tggatcgcga ctgtcaatgg ttcgatta
//
